Ke lāʻau lapaʻau ʻo Plevilox: nā ʻōlelo no ka hoʻohana ʻana

5 nā pā. - nā kāmele (1) - nā ʻeke pepa.
10 kamepiula - nā kāmele (1) - nā ʻeke pepa.
10 kamepiula - nā kāmele (2) - nā kīʻaha o ke kāleka.
100 pcs - nā ʻeke pepa (1) - nā kēla polymer.
1000 pcs - nā ʻeke pepa (1) - nā kēla polymer.
500 pcs - nā ʻeke pepa (1) - nā kēla polymer.
7 pcs - nā kāmele (2) - nā kīʻaha o ke kāleka.
7 pcs - nā kāmele (1) - nā ʻeke pepa.

Ka hana lāʻau lapaʻau

Kahi kikowaena antimicrobial mai ka hui o nā fluoroquinolones, hana bactericidal. Hoʻāla ia i ka pālahalaha o nā micro-positive a me ka gram-negative microorganisms, anaerobic, acid-resistant a atypical bacteria: Mycoplasma spp., Chlamydia spp., Legionella spp. Hoʻomaopopo i ka hoʻouluʻana i nā maʻi maʻi bacterial pale i ka beta-lactams a me nā macrolides. ʻO ia ke kū'ē i ka hapa nui o nā microorganism: gram-maikaʻi - Staphylococcus aureus (me nā ʻōpala ʻaʻole i hōʻeha i ka methicillin), Streptococcus pneumoniae (e komo pū ana me nā māla pale i ka penicillin a me nā macrolides), Streptococcus pyogenes (pūʻulu A), gram-negatif - Haemophilus influenzae a me nā non-beta-lactamase-paggawa i nā kailima), Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis (me nā pūnaehana like-beta a me ka non-beta-lactamase e hana nei i ka mana), Escherichia coli, Enterobacter cloacae, pyponia atypical Chlamydia. Wahi a nā haʻawina vitro, ʻoiai ʻo ka microorganisms i hōʻike ʻia ma lalo nei e pili ana i ka moxifloxacin, akā naʻe, ʻaʻole i hoʻokumu ʻia kona palekana a me ka paʻa i ka mālama ʻana i nā maʻi. Gram-maikaʻi meaola: Streptococcus milleri, Streptococcus mitior, Streptococcus agalactiae, Streptococcus dysgalactiae, Staphylococcus cohnii, Staphylococcus epidermidis (me ke kanana nei, methicillin ikepili koʻikoʻi), Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus, Staphylococcus simulans, Corynebacterium diphtheriae. Nā hui huaʻōlelo Gram-negatif: Bordetella pertussis, Klebsiella oxytoca, Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter Intermedius, Enterobacter sakazaki, Proteus mirabilis, Proteus vulgaris, Morganella morganii, Providencia rettgeri, Providencia stuartii. Anaerobic microorganisms: Bacteroides distasonis, Bacteroides eggerthii, Bacteroides fragilis, Bacteroides ovatus, Bacteroides thetaiotaornicron, Bacteroides uniformis, Fusobacterium spp, Porphyromonas spp, Porphyromonas anaerobius, Porphyromonas asaccharolyticus, Porphyromonas magnus, Prevotella spp, Propionibacterium spp, Clostridium perfringens, Clostridium .... ramosum. I nā poʻe hāpī manu: ʻO Legionella pneumophila, Caxiella burnettii.

Blocks topoisomerases II a me IV, nā hoʻomehana e mālama i nā waiwai topological o DNA, a pili pū i ka hoʻohuli ʻana o ka DNA, hoʻoponopono hou a hoʻāla ʻia. Hoʻokumu ka hopena o ka moxifloxacin i kona neʻe ʻana i ke koko a me nā kiko. Ka liʻiliʻi liʻiliʻi i nā hoʻoliʻi bactericidal ʻokoʻa loa mai ka ʻohi kikowaena neʻe iki.

ʻO nā hana hōʻihoʻi pale aku, ʻaʻole i hoʻouluulu ʻia nā penicillins, cephalosporins, aminoglycosides, macrolides a me tetracyclines, ʻaʻole i pili i ka hana antibacterial o moxifloxacin. ʻAʻohe kaʻa kūʻē ma waena o moxifloxacin a me kēia mau lāʻau. ʻAʻole mālama ʻia kahi mīkini hoʻomohala plasmid-mediated. ʻO ka haʻahaʻa holoʻokoʻa i ka haʻahaʻa. Ua hōʻike nā haʻawina vitro i ka pale ʻana i ka moxifloxacin e ulu mālie i ka hopena o ka hopena o ka hoʻohui ʻana. Me ka hōʻike pinepine ʻana i nā microorganisms me moxifloxacin i ka subminimal inhibitory concentrations, hoʻonui wale ka hōʻailona BMD. Hoʻomaopopo ka pale kūʻē ma waena o nā lāʻau lapaʻau mai ka hui fluoroquinolone. Eia nō naʻe, kekahi mau lolo-maikaʻi a me nā microorganism microorganism e kūpaʻa i nā fluoroquinolones e nānā i ka moxifloxacin.

Lapaʻau lāʻau

Ma hope o ka lawelawe waha, ua hoʻomoʻi pinepine ʻia ka moxifloxacin a kokoke loa. Ma hope o hoʻokahi ka manawa o moxifloxacin ma kahi o 400 mg C C i loko o ke koko e loaʻa ana i loko o nā hola 0.5-4 mau hola a ʻo 3.1 mg / L.

Ma hope o ka infusion hoʻokahi ma kahi o 400 mg no 1 h, hiki aku ʻo C max i ka hopena o ka infusion a ʻo 4.1 mg / l ka mea, e pili ana i ka hoʻonui ʻana o 26% e hoʻohālikelike ʻia me ka waiwai o kēia mau māka i lawe ʻia i ka waha. Me nā infusion IV āpau ma kahi hoʻokahi o 400 mg no ka hola 1, he ʻano like ʻo C max i ka pae mai 4.1 mg / l i 5.9 mg / l. Loaʻa nā awhi C ss o 4.4 mg / L ma ka hope o ka infusion.

ʻO ka bioavailability piha e pili ana i ka 91%.

ʻO ka pharmacokinetics o moxifloxacin i ka wā i lawe ʻia aku i loko o hoʻokahi mau hopena mai 50 mg i 1200 mg, me kahi paona o 600 mg / lā no 10 mau lā, ka laina.

Loaʻa ka manawa kūloko i loko o 3 mau lā.

ʻAkaʻa ʻia i nā protein koko (ʻo ka albumin ka nui) he 45%.

Hoʻolaha koke ʻia ka Moxifloxacin i nā aʻalolo a me nā lau. ʻO V d ka mea e like me 2 l / kg.

ʻO nā mea nui o ka moxifloxacin, e ʻoi aku i ka poʻe plasma, ua hana ʻia i loko o ka ʻōpū o ka pūpū (me nā alveolar macrophages), i ka membrane kuana o ka bronchi, i ka sinuses, i nā pā palupalu, nā ʻili a me nā hana subcutaneous, foci o ka mumū. I ka wai o interstitial a i loko o ka wai kai, mea hoʻoholo ʻia ka lāʻau lapaʻau i loko o kahi ʻano i hoʻopaʻa ʻole ʻia, ʻaʻole ʻano protein, ma kahi ʻano kiʻekiʻe ma mua o ka plasma. Eia kekahi, ua hoʻoholo ʻia ka ʻike kiʻekiʻe o ka hana ikaika i nā kino o ke kōpua o ka pūpū a me ka wai o ka peritoneal, a me ka nui o nā ʻili o nā ʻano wahine.

Hoʻokomo ʻia ʻo Biotransform i nā pūpono sulfo kaheʻe a me ka glucuronides. ʻAʻole nā ​​moloe ʻo Moxifloxacin i nā huila o nā molika mikrosomal o ka ʻōnaehana cytochrome P450.

Ma hope o ke hala ʻana i ka lua o ka manawa o ka biotransformation, ua kaomi ʻia ka moxifloxacin mai ke kino e nā ʻōpū a me nā ʻāpana, ʻaʻole i loli a i ke ʻano o ka pūhui sulfo inactive a me glucuronides.

Hoʻokuʻu ʻia ia i loko o ka mōnī, a me nā feces, ʻelua i loli a me ke ʻano o ka metabolite ʻole ʻole. Me kahi pākahi hoʻokahi 400 mg, ma kahi o 19% e keʻae ʻia i loko o ka urine, ma kahi o 25% me nā feces. ʻO T 1/2 kahi mau ma kahi o nā hola 12. ʻO ka nui o ka hoʻomaʻamaʻa ʻana ma hope o ka lawelawe ʻana ma kahi hapa o 400 mg ka 179 ml / min a i 246 ml / min.

Nā hōʻailona no ka hoʻohana ʻana

Nā maʻi o ka ʻōpū a me ke pākī o ka ʻōpū: ʻo ka sinusitis ka maʻi, ka hoʻonui ʻana o ka maʻi bronchitis, nā pneumonia i loaʻa i ke kaiāulu, nā maʻi o ka ʻili a me nā kiko palupalu, paʻakikī i nā maʻi intra-abdominal, me ka komo nā maʻi i hoʻoiho ʻia e kekahi mau pathogens, nā maʻi mālamalama uncomplicated o nā papa pelvic.

Pehea e hoʻohana ai: dosis a me ke ʻano o ka mālama ʻana

I loko a i ʻole ke ʻano o kahi infusion intravenous (lohi, ma luna o 60 mau minuke) - 400 mg 1 manawa i kēlā me kēia lā. Pulo ke papa o ka papa ʻaina, me ka inu ʻole ʻana, me ka ʻole o ka ʻaina. ʻO ke ala no ka hoʻomaʻamaʻa ʻana i ka maʻi bronchitis - 5 mau lā, pneumonia-loaʻa i ke kaiāulu - 10 mau lā, sinusitis mākia, nā maʻi o ka ʻili a me nā kiko palupalu - 7 lā, me nā maʻi paʻakikī intra-abdominal - i loko o 5-14 mau lā (iv me ka neʻe hou aku i ka lawelawe waha) , maʻi ʻole i nā maʻi maʻi pelvic i nā lā - 14 mau lā.

ʻAʻole pono e hoʻololi i ka hoʻoponopono o ka dosage i nā poʻe maʻi me nā maʻi hepatic (hui A, B ma ke keiki Child-Pugh) a me a / a i ʻole (me ka CC me ka haʻahaʻa 30 ml / min / 1.73 sq.m).

Nā hopena hopena

I ka manawa pinepine - 1-10%, loaʻa ʻole - 0.1-1%, ʻaʻole loa - 0.01-0.1%.

Mai ka pūnaehana ʻana: pinepine - ʻeha o ka ʻōpū, ka dyspepsia (me ka lemela, ka pohu, ka luaʻi, ka constipation, ke ʻeha), ka nui o ka hana ʻana o nā "transaminases" palu, ʻokoʻa - ka huina o ka huina o ka waha o ka waha, kandidiasis o ka mucosa waha. anorexia, stomatitis, glossitis, hoʻonui gamma-glutamintransferase, ke loaʻa loa loa - gastritis, discoloration o ka alelo, dysphagia, uila palaualelo.

Mai ka ʻaoʻao o ka ʻōnaehana ka hopena: pinepine - dizziness, headache, jarang - asthenia, insomnia or drowsiness, nervousness, kaumaha, tremors, paresthesias, loa loa - halepule, depersonalization, piʻi nui ke kani leo, koikoi pūpū o ka neʻe, ka hoʻopulapula, amnesia, aphasia, ka hana naʻau, ka hoʻohālikelike ʻana o ka hiamoe, ke kāhea ʻana o ka ʻōlelo, ka hoʻopuka ʻana o ka naʻau, hypesthesia, hoʻopaʻapaʻa, haunaele, ʻeha.

Ma ka ʻāpana o nā hui sensory: pinepine - kahi hoʻololi i ka ʻono, ʻokoʻa loa - ʻike ʻia ka ʻike maka, amblyopia, nalowale o ka ʻono naʻau, parosmia.

Mai ka CCC: jarang - tachycardia, hoʻonui i ke koko, palpitations, ʻeha ʻeha, ʻeha ʻana o ke kikowaena Q-T, ākea loa - hoʻemi i ke koko, vasodilation,

Mai ka papa hana hanu: luhi - pōkole o ka hanu, loaʻa pinepine - bronchial asthma.

Mai ka papa musculoskeletal: luhi - arthralgia, myalgia, loaʻa pinepine loa ka ʻeha o hope, ʻeha ʻeha, ʻehaʻeha, ʻehaʻī.

Mai ka ʻōnaehana genitourinary: līpoki - kandidiasis vaginal, vaginitis, ʻeha loa - ʻeha i ka ʻōpū o lalo, ke kuehue o ka helehelena, edema peripheral, hana ʻole.

He maʻi kūloko: jarang - wikiwiki, ʻeha, līkaha - urticaria, pīhoihoi anaphylactic.

Nā kūmole kūloko: pinepine - edema, mumū, ʻeha ma ka wahi i ʻōlelo ʻia, ʻaʻole liʻiliʻi - phlebitis.

Nā mākaʻina o ka laboratory: loaʻa - leukopenia, ka hoʻonui ʻana i ka manawa prothrombin, eosinophilia, thrombocytosis, he nui ke hoʻonui ʻana i ka hana amylase, ʻokoʻa loa - ka hoʻemi ʻana o ka hoʻoulu ʻana o ka thromboplastin, he hōʻemi i ka manawa prothrombin, thrombocytopenia, anemia, hyperglycemia, hyperlipidemia, hyperuricemia, he hoʻonui. ʻAʻole i hōʻike ʻia ka pilina me ka ʻākala o ka lāʻau: he hoʻonui a hōʻemi paha i ka hematocrit, leukocytosis, erythrocytosis a erythropenia, heʻano hoʻokaʻawale o ka glucose, Hb, urea, i ka hoʻonui ʻia ʻana o ka hana alkatine phosphatase.

Nā mea ʻē aʻe: hiki ʻole - candidiasis, hōʻano maʻamau, hoʻopau.

Nā ʻōlelo kikoʻī

I ka wā o ka maʻi me ka fluoroquinolones, hoʻomohala a hoʻoweliweli ka tendon e hoʻomohala, ʻoi aku hoʻi i ka poʻe maʻi maʻi a me nā mea maʻi e loaʻa pū ana me corticosteroids. I nā hōʻailona mua o ka hōʻeha a me ka ʻaihue o nā tendons, e hōʻemi nā mea maʻi i ka mālama ʻana a hoʻohemo ʻole i ka umauma i hoʻopilikia ʻia.

Aia kekahi kikoo pololei ma waena o ka hoʻonui i ka neʻe o ka moxifloxacin a me ka hoʻonui ʻana i ka kikowaena Q-T (ʻo ka hopena o ka hoʻoulu ʻana i ka arrhythmias ventricular, me ka torsades de pointes) I ke hopena o kēia mea, pono nā mea i ʻōlelo ʻia ma ke ʻano (400 mg) ʻaʻole pono e hoʻonui ʻia a pono ke hoʻopau ʻia ka infusion (ma kahi o 60 mau minuke).

Ma ka hihia o ka hopena nui i ka wā e hoʻōla ai, pono e hoʻokuʻu ʻia ka lāʻau lapaʻau.

Hoʻohui

ʻO nā antacids, mineral, multivitamins impair absorption (ma muli o ka hoʻokumu ʻana i nā paina chelate me nā c polyvalent cases) a me ka hoʻēmi ʻana i ka neʻe ʻana o ka moxifloxacin i ka plasma (hiki i ka lawelawe wā like i ka wā o 4 mau hola ma mua a i ʻole 2 mau hola ma hope o ka lawe ʻana i ka moxifloxacin).

Hoʻohui i ka hoʻohana me nā quinolones e hoʻonui i ka hopena i ka hoʻolōʻihi i ka paila Q-T.

Hoʻopilikia iki pinepine i nā pākuʻi pharmacokinetic o ka digoxin.

Hoʻonui ka GCS i ka hopena o ka tendovaginitis a tendon rupture paha.

Ua hui pū ʻia ka hopena infusion me ka hopena lāʻau lapaʻau e pili ana i ka hopena: 0.9% a me ka hopena 1 molar NaCl, ka wai no ka hōʻemi ʻana, nā hopena dextrose (5, 10 a me 40%), 20% xylitol solution, ka hopena o Ringer, Ringer-lactate, 10% hopena Aminofusin, hopena. Yonosteril.

Kāhea ʻole i nā hoʻonā 10 a me 20% NaCl, nā 4.2 a me 8.4% Na bicarbonate hopena.

E hoʻokuʻu i ke ʻano a me ka ʻano

ʻO ka hoʻokuʻu i ka mana o ka lālani nā papa ʻoniʻoni ʻoniʻoni. Aia kēlā me kēia papa i ka 436.4 mg o moxifloxacin hydrochloride, kahi e kū nei me 400 mg o moxifloxacin. Nā māhele liʻiliʻi:

• pulu ʻulaʻula kala,
• hydroxypropyl methylcellulose,
• konekena stearate,
• MCC
• sodium polio
• liʻawaʻawa lactose.

Hoʻonohonoho ʻia ka lāʻau lapaʻau i nā poli o 5, 7 a i ʻole 10 mau pcs. a i ʻole i nā pahu polū he 100, 500 a i ʻole 1000 pcs. (no nā hui olakino). Aia ka pahu i ka 1, 2 mau palima a i ʻole 1 mauʻaina polymer.

Lapaʻau lāʻau

ʻO ka lāʻau lapaʻau ka maʻi fluoroquinolone a he hopena bactericidal.

Nā ʻōkuhi aerobic Gram-hewa i kahi ʻokoʻa ʻē aʻe o ka naʻau ma ka hana o ka lāʻau lapaʻau.

ʻO kāna hana koʻikoʻi e hoʻopili i ka hoʻopili ʻana o ka DNA o nā microorganisms kino, a laila e kōkua ana i ka make wikiwiki ʻana. Aerobes gram-positive is sensitable it: Staphylococcus aureus, Streptococcus dysgalactiae, Streptococcus mitis, Staphylococcus saprophyticus, Streptococcus agalactiae, Staphylococcus hominis, Haemophilias parainfluenzae, Enterobacter cloae.

Nā microamers aerobic Gram-hewa i kahi ʻokoʻa o ka naʻau o ka hana o ka lāʻau lapaʻau: Porphyromonas asaccharolyticus, Bacteroides ovatus, Porphyromonas asaccharolyticus, Prevotella spp., Mycoplasma pneumonia, Coxiella bumettii.

ʻO ka naʻau hāleʻa i ka antibiotic: Stenotrophomonas maltophilia, Burkholdera cepacia, Pseudomonas aeruginosa.

Ua hōʻike ʻia kahi hihia o ke kūʻē ʻana i nā lāʻau ʻē aʻe mai ka pūʻulu o nā fluoroquinolones.

Nā Hoʻohui

Ke papa aku nei i ke kuhikuhi i ka lāʻau i loko o ia mau hihia:

• maʻi mellitus maʻiʻi
• epilepsy
• nā maʻi maʻi kaumaha
• malalo o 18 makahiki
• hypokalemia mamaʻi,
• lactation
• hapai

Pono e mālama ʻia i ka maʻi pakanā hepatic pathology, hypokalemia, convulsive syndrome, lōʻihi QT interval, pseudomembranous colitis, hui pū me corticosteroids. Eia kekahi, pono e kuhikuhi ʻia ka lāʻau lapaʻau me ka mālama ʻana i nā poʻe maʻi e holo ana i ka hemodialysis.

Ke keu

Hiki i kekahi mea maʻi ke hōʻeha, nā kuʻekuʻe, nā maʻi maʻi, ka luaʻi a me ka hiamoe i ka wā e hoʻohana ai i nā overdoses o kahi lāʻau maʻi.

ʻO ka Therapy ke hoʻomaʻemaʻe ʻana i ka bowel a me ka hoʻohana ʻana i nā lāʻau lapaʻau kino.

Nā hōʻailona hou aku ka hōʻailona a pono e hana ʻia ma lalo o ka mālama ʻana o kahi mākaʻi ECG. ʻAʻole i loaʻa ka antidote o ka waiwai.

Hoʻohui nūhou

Ke hui pū me ka lāʻau lapaʻau, minerids, antacids, multivitamins e hoʻomohala i kona komo ʻana a e hōʻemi i ka pae ʻana o ka plasma.

ʻO ka hoʻohanaʻana i kahi antibiotic me nā quinolones e alakaʻi i ka hiʻohiʻona o nā hōʻike phototoxic.

Hoʻopili ke Ranitidine i ka hoʻopili ʻana o ka moxifloxacin.

He kumukūʻai ma nā hale kūʻai

Hoʻomaka ke kumukūʻai o kahi lāʻau lapaʻau mai 620 mau rubles. no na papa 5 ma kahi pa.

Inā aia nā contraindications i ka lāʻau lapaʻau a i kona haʻalele ʻole ʻana i ka mākeke i ka manawa kūʻai, hiki iā ʻoe ke hāʻawi i ka makemake i kekahi o nā lāʻau lapaʻau e like me kēia;

• Maxiflox
• Alvelon-MF,
• Aquamox
• Avelox,
• Moksimak,
• Megaflox,
• Moxigram
• Vigamox
• Moxiflo
• Moʻokuʻaka
• Moxispenser
• Moxifloxacin Canon,
• Moxifloxacin hydrochloride,
• Moxifloxacin-Optic,
• Moxifloxacin-Alvogen,
• Moxifur
• Simoflox,
• Ultramox
• Moflaxia,
• Heinemox.

Boris Belyaev (urologist), kūlanakauhale o Balakovo

ʻO ka huehue kīʻaha ʻehā fluoroquinolone. ʻO ka hopena ka aneane 100% wānana. Ua liʻiliʻi nā hopena ʻaoʻao. Ke kuhikuhi nei wau ia no ka hoʻomaʻamaʻa ʻana o ka urethritis ka hana a me ka prostatitis.

Tatyana Sidorova, 38 makahiki, ke kūlanakauhale o Dzerzhinsk

Me ke kōkua o kēia lāʻau lapaʻau, ua hoʻōla ʻia ʻo mycoplasmosis. ʻO ka hoʻoponopono regimen ʻoluʻolu - 1 ka manawa i kēlā me kēia lā, ʻaʻohe ola hou o ka maʻi a me kekahi o kāna mau hōʻailona. Ua loaʻa kēia hopena i nā lā 8-9 o ka lawe ʻana i ka lāʻau lapaʻau.

Kristina Verina, 25 makahiki, ke kūlanakauhale o Zelenogorsk

I loko o ka haukapila, ua hōʻike wau i ka maʻi maʻi o ka maʻi pneumonia, ma hope o ko lākou hoʻoku ʻana iaʻu i loko o ka haukapila no 10 lā. Ke hoʻoneʻe nei i ka lāʻau maʻi outpatient, ua kuhikuhi pū ʻia kēia lāʻau lapaʻau me ka doxycycline. ʻAʻole au i nānā i kekahi mau hopena i hōʻike ʻia i loko o nā ʻōlelo kuhikuhi, ʻaʻohe ʻoluʻolu i ke ʻano holoʻokoʻa o ka lawe ʻana i ka lāʻau. I kēia manawa ua hoʻihoʻi nui ʻia au a mālie wau.

Vera Ignatyeva, 34 makahiki, ke kulanakauhale o Kalach-on-Don

I koʻu wā i ʻike ai i ka cystitis, hoʻomaka wau e hoʻohana iā Aquamox, akā loaʻa iaʻu kahi maʻi pākī. Ua kāpae ke kauka iā ia me ka plevilox. Ua lawe mālie koʻu kino i kēia lāʻau lapaʻau. Ua hoʻopau ʻia ka maʻi i nā hebedoma 1,5 o ka hoʻokele mau ʻana i ka lāʻau i nā pakanana i hōʻike ʻia.

ʻŌpū a me ka lactation

ʻAʻole paʻa i ka palekana o ka moxifloxacin i ka wā hāpai.

Ua hoʻākāka ʻia kahi pōʻino hōʻiliʻili i nā keiki i mālama ʻia me nā maʻi quinolone e like me, akā ʻaʻole i hōʻike ʻia kahi hopena like ʻole ma ka hōʻike ʻana i ka maʻi. Hōʻike nā haʻawina holoholona i nā hana hoʻohālikelike hua.

Hoʻohana ʻia ka hoʻohana ʻana o moxifloxacin i ka wā hāpai ʻana.

E like me nā antibiotics quinolone, he maikaʻi ka hopena o ka moxifloxacin i ka hoʻomohala ʻana a me ka ulu ʻana o ka iwi cartilage i ke kākoʻo ʻana i nā holoholona ʻōpiopio.

ʻO kahi hapa liʻiliʻi o moxifloxacin i hoʻopili ʻia i ka waiū umauma. ʻAʻole ʻike nā ʻikepili ma ka hoʻohana ʻana i ka moxifloxacin i loko o nā wahine i ka wā lactation a me ka hānai ʻana.

Hoʻohana ʻia ka hoʻohana ʻana o moxifloxacin i nā wahine hānai.

ʻO ka ʻikepili palekana preclinical

I nā haʻawina o ke ahonui i nā ʻīlio, ʻaʻohe hōʻailona o ka intolerance ke hoʻohana ʻana i ka moxifloxacin intravenously. Ma hope o ka hoʻokomo ʻana i ka intraarterial, ua ʻike ʻia nā hoʻololi ʻana e pili ana i ka wā palemalula nā wāalthial, kahi e hōʻike nei e pono ke hoʻopale ʻia intraarterial moxifloxacin.

ʻLoe a me ke kākele

Nā pākeke

ʻO ka pona o Plevilox 400 mg (1 papa) i kēlā me kēia 24 hola. Aia nō ka lōʻihi o ke kauka i ke ʻano o ka maʻi, e like me ka mea i wehewehe ʻia i ka papa 1.

Papa 1: Nā maʻi a me ka lōʻihi o ka lapaʻau i nā maʻi pākeke

Kūleʻa i kēlā me kēia 24 hola

Ka lōʻihi b (nā lā)

Sinusitis huapalapala huehue

ʻO ka maʻi exacerbation o kahiʻeha bronchitis

ʻO ka holo ʻole ʻia o ka ʻili a me nā kālai

Hoʻopau piha ʻia o ka ʻili a me kāna mau ʻoihana

Hoʻopilikia i nā maʻi kolohe Intraabdominal

He kumu e nā ʻōpū i luna (ʻike i ka ʻāpana "Hōʻike ʻia no ka hoʻohana").

6 Ka ʻona ʻeuʻeu manawa (intravenously a laila e kuhikuhi ʻia), e kuhikuhi ʻia ma ke ʻano o ke kauka.

Hōʻike ʻia ka hoʻokele intravenous inā ʻoi aku kēia mea e pono ai ka mea hoʻomalu i ka mea maʻi (no ka laʻana, ʻaʻole hiki i ka mea maʻi ke lawe i ka puka waha waha). Ke hoʻololi nei mai ka hoʻokele intravenous i ka hoʻoponopono waha, ʻaʻole pono ke hoʻoponopono ʻia. ʻO nā mea maʻi e hoʻomaka ai ka lāʻau maʻi me ka hoʻokele intravenous o moxifloxacin e hiki ke hoʻouna ʻia i nā papa e like me nā hōʻailona olakino ma ke ʻano o ke kauka.

Nā Hoʻohui kūikawā

I nā poʻeʻelemakule a me nā mea maʻi me ke kaumaha haʻahaʻa, ʻaʻole pono ka hoʻoponopono ʻana o ka lāʻau.

Hoʻopili ʻia ʻo Moxifloxacin i nā keiki a me nā ʻōpio (

Nā hiʻohiʻona noi

Ka huiloʻi hoʻopili huna

Ke aʻo nei i ka hopena o moxifloxacin ma ka hana reproduction i loko o nā mea hana nui, ka pīpī a me nā mea nui, ua hōʻike ʻia ma ka moxifloxacin e hele i ka plasenta. Nā haʻawina ma nā mea nui (i ka wā e hoʻohana ana i ka moxifloxacin ma ke ʻano a me ka intravenously) a me nā mau monkey (i ka wā e hoʻohana ana i ka moxifloxacin i loko) ʻaʻole i hōʻike i ka hopena teratogenic o moxifloxacin a me kona hopena i ka hānai. Me ka hoʻohana nui ʻana o ka moxifloxacin i nā pīpī ma kahi wai o 20 mg / kg, ʻike ʻia nā kolohe o ka huakaʻi. Hoʻohālikelike kēia mau ʻikepili me nā hopena i ʻike ʻia e nā quinolones ma ka hoʻomohala i ka ulu. I ka hoʻonui ʻia ʻana o ka nui o nā hemahema i nā moole a me nā huaʻala i hōʻike ʻia me ka hoʻohana ʻana i ka moxifloxacin i kahi lāʻau lapaʻau. I loko o nā lālani, aia ka emi ʻana o ke kaupaona o ka wahine, ʻoi aku ka nui o nā hana kolohe, hōʻemi iki ʻia i ka lōʻihi o ka manawa o ka gestation a me ka hoʻonui ʻana o ka hana kuʻina o nā ʻano o nā kāne a i ka wā e hoʻohana ai i ka moxifloxacin, ʻo ka nui o kēia mau manawa he 63 mau ʻoi aku o ke ahonui i hana ʻia i loko o nā kānaka.

Hoʻomaʻa i ka hiki ke alakaʻi i nā kaʻa a me nā mea ʻē aʻe ʻē aʻenā mīkini hana

ʻO nā Fluoroquinolones, me ka moxifloxacin, hiki ke alakaʻi i ka hiki ke hoʻoweliweli i nā kaʻa a i ʻole nā ​​mea ʻē aʻe e pilikia ai ma muli o nā hopena mai ka pūnaehana waena.

ʻO nā mea mālama palekana

I kekahi mau pilikia, ma hope o ka hoʻohana mua ʻana o ka lāʻau, ulu ka hypersensitivity a me nā hopena alia. Kuhi iki loa, hiki i nā hopena anaphylactic ke holomua i ka hana hoʻoweliweli hoʻoweliweli o ke ola, ʻoiai ma hope o ka hoʻohana mua ʻana o ka lāʻau. I kēia mau hihia, pono e hoʻoneʻe ʻia ka moxifloxacin a me nā ʻano lāʻau lapaʻau e pono i lawe ʻia (me ke ʻano anti-shock).

Ua hōʻike ʻia nā pilikia o ka hepatitis fulminant, hiki ke alakaʻi ʻia i ka nui o ke ola hōʻeha ola, me ka make. Inā ʻike ʻia nā hōʻailona o ka ate, pono e nīnau aku nā mea maʻi i ke kauka ma mua o ka hoʻomau ʻana i ka mālama ʻana.

Inā hele mai nā hopena ma ka ʻaoʻao o ka ʻili a me / a i ʻole nā ​​membous mucous, pono ʻoe e nīnau koke i ke kauka ma mua o ka hoʻomau ʻana i ka mālama ʻana. ʻO ka hoʻohana ʻana i nā lāʻau quinolone e pili ana i ka hiki i ka hoʻomohala ʻana i ka lawe ʻaʻi ʻana. Pono ke hoʻohana ʻia ʻo Moxifloxacin me ka mālama ʻana i nā maʻi me ka maʻi ʻōnaehana o ka nūnū a me nā kūlana e kānalua nei i ka hoʻopili ʻana o nā hanana ʻōnaehana waena, e kuhi ana i ka mea e hoʻokuʻi ʻia nā hoʻokuʻi, a me ka hoʻohaʻahaʻa ʻana i ka paepae no ka hana hoʻomanawanui.

ʻO ka hoʻohana ʻana i nā lāʻau antibacterial ākea ākea, me ka moxifloxacin, i hoʻopili ʻia me ka pilikia o ka hoʻomohala ʻana i ka colitis pseudomembranous i pili me ka lawe ʻana i ka antibiotics. Pono e mālama i kēia maʻi i loko o nā poʻe maʻi e ʻike i ka maʻi kaumaha ma ka wā me ka moxifloxacin. I kēia hihia, pono e hoʻomaopopo koke i ka lāʻau kūpono. ʻO nā maʻi i loaʻa i ka maʻi palaualelo e pāpā ʻia i nā lāʻau lapaʻau e pale i ka ʻōpū o ka wahī.

Pono ke hoʻohana ʻia ka Moxifloxacin me ka makaʻala me nā poʻe maʻi me Gravis myasthenia gravis, no ka mea hiki i ka lāʻau lapaʻau ke hoʻonui i nā hōʻailona o kēia maʻi. I ka wā o ka maʻi me ka fluoroquinolones, me ka moxifloxacin, ka mea nui i nā poʻe maʻi e loaʻa ana i ka glucocorticosteroids, tendonitis a tendon rupture e ulu. I nā maka mua o ka hōʻeha a me ka mumū paha ma ka pūnaewele hōʻehaʻeha, pono e hoʻoneʻe i ka lāʻau a hōʻoluʻolu ʻia ka umauma i hoʻopilikia ʻia.

No nā mea maʻi me nā maʻi maʻi paʻakikī o nā pelvic organ (no ka laʻana, ka pili me ka tubo-ovarian a i ʻole nā ​​pelvic abscesses) i hōʻike ʻia no ka maʻi intravenous, ʻo ka hoʻohana ʻana o ka moxifloxacin i nā papa 400 mg ʻaʻole ʻia.

Ke hoʻohana nei i ka quinolones, ʻike ʻia nā hōʻike photosensitivity. Eia nō naʻe, i ka wā o ka preclinical, hoʻopaʻa haʻawina, a me ka hoʻohana ʻana i ka moxifloxacin i loko o ka hoʻomaʻamaʻa, ʻaʻohe ʻike ma ka photosensitivity. Eia naʻe, ʻo nā mea maʻi e loaʻa ana i ka moxifloxacin e pale pono i ka lā a me ka radiation ultraviolet.

Hoʻopule i waenaQTca me nā kūlana e pili ana i nā maʻi lapaʻau

I loaʻa ʻia ua moxifloxacin e hoʻolōʻihi i ka manawa QTc ma ka electrocardiograms o kekahi mau maʻi. I ka wā o ka loiloi o ECG i loaʻa ma ke ʻano o ka papahana hoʻokolokolo haukole, ʻo ka lōʻihi o ka manawa QTc i ka wā e lawe ai i ka moxifloxacin he 6 milliseconds ± 26 milliseconds, ʻo ia ka 1.4% hoʻohālikelike i ka pae mua. Ma muli o ka lōʻihi o ka lōʻihi o ka manawa QTc i nā wāhine, ʻoi aku ka lōʻihi o nā kāne, ʻoi aku paha ka nui o nā wahine i ka hana o nā lāʻau lapaʻau e hoʻomau ana i ka QTc. ʻOi aku ka maʻalahi o nā poʻe'ōpio i nā hopena o ka lāʻau lapaʻau ma ka interval QT.

Hiki ke hoʻonui ʻia i ka pae o ka lohi o ka palena QT me ka hoʻonui ʻana i ka manaʻo o ka lāʻau, no laila ʻaʻole pono e hoʻonui ʻia ke ʻano i ʻōlelo ʻia. ʻO ka hoʻonui ʻana i ke anawaʻina ʻo QT ua pili i ka nui o ka loaʻa o ka arrhythmias ventricular, me ka tachycardia polymorphic ventricular. Eia nō naʻe, i nā mea maʻi me ka maʻi pīpī, ʻaʻohe correlation ma waena o ka neʻe o ka moxifloxacin i loko o ke koko koko a me ka lōʻihi o ka manawa QT. ʻAʻole kekahi o nā mea maʻi 9,000 i mālama ʻia me moxifloxacin i hoʻopiʻi ʻia na maʻi cardiovascular a me nā make e pili ana i ka hoʻonui ʻana QT. Eia nō naʻe, i nā mea maʻi me nā kūlana i manaʻo mua i nā arrhythmias, hiki i ka hoʻohana ʻana i ka moxifloxacin e hoʻonui i ka nui o ka arrhythmias ventricular.

I kēia mea, pono ke ʻalo ʻia ka hoʻokele o moxifloxacin i ka poʻe maʻi me ka hoʻokaʻawale QT lōʻihi, hypokalemia uncorrected, a ʻo ia hoʻi i ka poʻe i loaʻa i ka papa o ka antiarrhythmic ʻAlola (quinidine, procainamide) a i ʻole kelas III (amiodarone, sotalol), mai ka ʻike no ka hoʻohana ʻana i ka moxifloxacin i kēia mau maʻi. kūlohelohe. Pono ke ʻano o ka Moxifloxacin me ka akahele, no ka mea hiki ʻole ke hoʻokaʻawale ʻia nā hopena moxifloxacin i loko o kēia mau ʻano:

i nā mea maʻi e loaʻa ana ka hana kūpono me nā lāʻau lapaʻau e hoʻolalelale ana i ka palena QT (cisapride, erythromycin, nā lāʻau antipsychotic, antidepressants tricyclic),

i nā mea maʻi me nā kūlana e hoʻomaka ana i nā arrhythmias, e like me ka bradycardia koʻikoʻi i nā maʻi nui, ischemia myocardial

i nā mea maʻi me ka cirrhosis, ʻoiai me ka loaʻa ʻana o kahi pālahalaha o ka interval QT i loko o lākou ʻaʻole hiki ke haʻalele ʻia,

i nā wahine a i nā maʻi maʻi maʻi paha i ʻoi aku ka paʻakikī i nā lāʻau lapaʻau e hoʻonui i ka manawa QT,

Inā hele mai nā hōʻailona o ka arrhythmia cardiac i ka wā e mālama ai me ka moxifloxacin, pono ʻoe e hoʻōki i ka lawe ʻana i ka lāʻau a hana i kahi ECG.

Ke lāʻau lapaʻau ʻo Plevilox: nā ʻōlelo no ka hoʻohana ʻana

Hiki i ka lāʻau maʻi antibiotika ʻo Plevilox ke hakakā me nā maʻi he nui, nā māka kumu kumu ʻo nā mea ʻalaʻawa e nānā aku i kāna hana. Eia naʻe, ʻo ka lāʻau lapaʻau e pono ai e kuhikuhi ʻia e nā loea wale nō, no ka mea pono ke kōkua ponoʻī iā ʻoe iho i nā hopena hiki ʻole.

Hoʻonoho ka Plevilox iā ʻoe e hakakā i nā maʻi he nui, nā mālamalama kumu kumu o nā microorganism i pili i kāna hana.

14 ʻO nā loulou

Inā aia nā contraindications i ka lāʻau lapaʻau a i kona haʻalele ʻole ʻana i ka mākeke i ka manawa kūʻai, hiki iā ʻoe ke hāʻawi i ka makemake i kekahi o nā lāʻau lapaʻau e like me kēia;

• Maxiflox
• Alvelon-MF,
• Aquamox
• Avelox,
• Moksimak,
• Megaflox,
• Moxigram
• Vigamox
• Moxiflo
• Moʻokuʻaka
• Moxispenser
• Moxifloxacin Canon,
• Moxifloxacin hydrochloride,
• Moxifloxacin-Optic,
• Moxifloxacin-Alvogen,
• Moxifur
• Simoflox,
• Ultramox
• Moflaxia,
• Heinemox.

Boris Belyaev (urologist), kūlanakauhale o Balakovo

ʻO ka huehue kīʻaha ʻehā fluoroquinolone. ʻO ka hopena ka aneane 100% wānana. Ua liʻiliʻi nā hopena ʻaoʻao. Ke kuhikuhi nei wau ia no ka hoʻomaʻamaʻa ʻana o ka urethritis ka hana a me ka prostatitis.

Tatyana Sidorova, 38 makahiki, ke kūlanakauhale o Dzerzhinsk

Me ke kōkua o kēia lāʻau lapaʻau, ua hoʻōla ʻia ʻo mycoplasmosis. ʻO ka hoʻoponopono regimen ʻoluʻolu - 1 ka manawa i kēlā me kēia lā, ʻaʻohe ola hou o ka maʻi a me kekahi o kāna mau hōʻailona. Ua loaʻa kēia hopena i nā lā 8-9 o ka lawe ʻana i ka lāʻau lapaʻau.

Kristina Verina, 25 makahiki, ke kūlanakauhale o Zelenogorsk

I loko o ka haukapila, ua hōʻike wau i ka maʻi maʻi o ka maʻi pneumonia, ma hope o ko lākou hoʻoku ʻana iaʻu i loko o ka haukapila no 10 lā. Ke hoʻoneʻe nei i ka lāʻau maʻi outpatient, ua kuhikuhi pū ʻia kēia lāʻau lapaʻau me ka doxycycline. ʻAʻole au i nānā i kekahi mau hopena i hōʻike ʻia i loko o nā ʻōlelo kuhikuhi, ʻaʻohe ʻoluʻolu i ke ʻano holoʻokoʻa o ka lawe ʻana i ka lāʻau. I kēia manawa ua hoʻihoʻi nui ʻia au a mālie wau.

Vera Ignatyeva, 34 makahiki, ke kulanakauhale o Kalach-on-Don

I koʻu wā i ʻike ai i ka cystitis, hoʻomaka wau e hoʻohana iā Aquamox, akā loaʻa iaʻu kahi maʻi pākī. Ua kāpae ke kauka iā ia me ka plevilox. Ua lawe mālie koʻu kino i kēia lāʻau lapaʻau. Ua hoʻopau ʻia ka maʻi i nā hebedoma 1,5 o ka hoʻokele mau ʻana i ka lāʻau i nā pakanana i hōʻike ʻia.

ʻO Angelina Marinina, 44 makahiki, ke kūlanakauhale ʻo Vladimir

Ua mālama ʻia me kēia mau penikala no ka pneumonia. ʻO kahi mālama maʻi kūpono e kōkua wikiwiki. Eia naʻe, ma hope o ka hoʻohana ʻana i ka lāʻau lapaʻau, loaʻa iaʻu ka thrush. Wahi a ke kauka he mea maʻamau kēia. ʻO wau e hoʻohui hou aʻe iā Diflucan.

Hoʻolaha puka Plevilox

400 mg papaʻaina i hana ʻia, pahu ʻōmaʻomaʻo 5 mau kāleka o ka kāleka 1,

400 mg papaʻaina i hana ʻia, pale ʻia 7 mau kāleka o ka kāleka 1,

400 mg papaʻaina i hana ʻia, pale ʻia 10 mau kāleka o ka kāleka 1,

400 mg papaʻa e kau ai i nā paʻi, he 7 mau pōpō o ka pahu pepa 2,

400 mg papaʻaina i hana ʻia, pahu 10 mau peke o ka pahu pepa 2,

400 mg papaʻa e kau ai i nā paʻi, polyethylene bag (sachet) 100 mau (hiki ke hoʻolako) ka polymer 1,
400 mg papaʻa e kau ai i nā paʻi, nā ʻeke palaka (sachet) 500 hiki (kahepa) he ʻōmole 1,
400 mg papaʻa e kau ai i nā paʻi, ʻoki aila (sachet) 1000 iʻa (ʻae) polimera 1,

Hoʻolaha ATX:

J Antimicrobial no ka hoʻohana ʻana i nā ʻōnaehana

ʻO nā lāʻau lapaʻau J01 Antimicrobial no ka hoʻohana maʻamau

J01M Antibacterials - quinolone derivatives

Hiki ke hoʻohana ʻia ka annotation no ka lāʻau lapaʻau ʻo Plevilox ma kēia ʻaoʻao o ka pūnaewele no ka hoʻohana pono ʻana i nā lā āpau.

ʻO ka pākuʻi lāʻau

Nā hōʻailona: hiki ke emi o ka hana, ke hiamoe, ka luaʻi, ka maʻi ʻana, ka mea o ka puʻuwai kino, ka hoʻopaʻi ʻana. Hanaʻi: lavage gastric (i nā hola ʻelua o hope ma hope o ka overdose), nānā, ka hana hōʻailona me ka mālama ʻana o ECG. ʻAʻohe mea kikoʻi manuahi e pono ai e hōʻoia i ka komo ʻana o ka wai paʻa i loko o ke kino a ʻo ka mālama ʻana i ka diuresis e lawa ai.

Kūlana kūikawā no ka hoʻohana o ka lāʻau lapaʻau

I mea e hōʻemi ai i ka hopena o ka hoʻomohala ʻana i ka kūʻē i ka moxifloxacin a i ka mālama ʻana i nā pono o nā māiʻe antibacterial, pono ke kuhikuhi ʻia ka moxifloxacin wale nō no ka mālama ʻana i nā maʻi i hoʻāhewa ʻia e nā mākeke pili i kēia lāʻau. I ka wā hana, pono ka nānā ʻana o ka ECG (ka lōʻihi o ka manawa QT, nā arrhythmias ventricular). Hiki ke hoʻonui ʻia i ka pae o ka lohi o ka palena QT me ka hoʻonui ʻana i ka manaʻo o ka lāʻau, no laila ʻaʻole pono e hoʻonui ʻia ke ʻano i ʻōlelo ʻia. ʻO ka hoʻonui ʻana i ka neʻelā QT e pili pū me ka nui o ka loaʻa o ka arrhythmias ventricular, me ka flicker-flutter. I ka wā o ka maʻi me ka fluoroquinolones, me ka moxifloxacin, ka mea nui i nā poʻe maʻi e loaʻa ana i ka glucocorticosteroids, hiki i ka hoʻomohala ʻana o ka tendonitis a me ka rupture tendon. I nā maka mua o ka hōʻeha a me ka mumū paha ma ka pūnaewele hōʻehaʻeha, pono e hoʻoneʻe i ka lāʻau a hōʻoluʻolu ʻia ka umauma i hoʻopilikia ʻia. Ma ka hihia o ka hōʻeha kaumaha i ka wā o ka mālama ʻana me moxifloxacin, pono e hoʻokuʻu ʻia ka lāʻau a kūpono hoʻi ke kuhikuhi ʻia i kahi lāʻau lapaʻau. I kekahi mau hihia, hiki i nā hopena maʻi maʻamau ke hoʻomohala, me ke ʻano hoʻoweliweli o ka anaphylactic hoʻoweliweli. I kēia mau hihia, pono e hoʻokaʻawale ka moxifloxacin a me nā mea e pono ai (me nā antishock) e kuhikuhi ʻia: nā glucocorticosteroids, norepinephrine, antihistamines. ʻAʻole loaʻa nā mea muxifloxacin i nā mea phototoxic. Eia naʻe, ʻo nā mea maʻi e loaʻa ana i ka moxifloxacin e pale pono i ka lā a me ka radiation ultraviolet. ʻOiai ʻo ka moxifloxacin hiki ʻole i ka luhi ka hopena mai loko o ka nū o ka nūnaehana kikowaena, pono e ʻike nā mea maʻi i kā lākou hopena ma ka lāʻau i mua o ka lawe ʻana i ka mīkini.