Amikacin Sulam (Amikacini Sulam)

ʻO ka pauka no ka hana ʻana i kahi hopena i manaʻo ʻia no ka hoʻokele intravenous a i ʻole intramuscular e keʻokeʻo mau ana a kokoke i keʻokeʻo paha, hygroscopic.

1000, 500 a 250 mg paha o ka pauka i loko o kahi pahu o 10 ml, 1, 5, 10 a 50 paha o kēlā mau hue i loko o kahi ʻāpana pepa.

ʻO ka hāleʻa (intravenous, intramuscular) maʻa mau ka maopopo, ʻōmaʻomaʻo ka ʻulaʻula ʻole.

ʻAʻohe ʻano e hoʻokuʻu i nā papa.

Lapaʻau lāʻau

ʻO Amikacin (inoa i ka ʻōkuhi ma Latin Amikacin) he semi-synthetic AlohaʻArie (nā maʻi maʻi) e hana ana i kahi pālahalaha ākea. Nā Kihi bactericidal hana. Hoʻopili koke ia i loko o ka paia o ka pā o ka pathogen, paʻa loa i ka subunit o ka 30S ribosome o ka hua bakela a pale i ka biosynthesis protein.

Hoʻolaha ka hopena i ka pathogens aerobic aerobic: Salmonella spp., Enterobacter spp., Escherichia coli, Klebsiella spp., Pseudomonas aeruginosa, Shigella spp., Serratia spp., Providencia stuartii.

Hoʻomaʻamaʻa kūleʻa e kū'ē i nā maʻi a me ke kūpaʻa o ka gram: Staphylococcus spp. (e komo pū ana me nā Metilene-kūmau kūmau), he nui o nā māla Streptococcus spp.

Hoʻokomo ʻia nā huakini aerobic i ka amikacin.

Lapaʻau lāʻau

Ma hope o ka hoʻomehana intramuscular, ua hoʻopili ikaika ʻia ʻo ia ma ka helu piha i hoʻokō ʻia. Penetrates i loko o nā kiko āpau a ma o nā pale o ka histohematological. ʻO ka pilina ʻana i nā protein koko ke piʻi a i ka 10%. ʻAʻole kūlike i ka hoʻololi. Ke hoʻohālikelike ʻia nei ia ma o nā aka i loli ʻole. Hoʻomaka ka hapa hoʻopau hapa-ola i nā hola 3.

Nā ʻōmaka ʻAmelika

ʻO nā ʻōmaka no ka hoʻohana ʻana iā Amikacin kahi maʻi maʻi infectious-inflammatory e nā micro-negative microorganism (kū i ka ʻiliʻala, kanamycin a i ʻole sisomycin) a i ka manawa like ʻole gram-maikaʻi a me nā micro-kino microorganisms:

• nā maʻi hanu (nā maʻi pīpī, empyema o ka pleura, bronchitis, huhū o ka pūpū),
• sepsis,
• pepela endocarditis,
• lolo maʻi (komo meningitis),
• maʻi maʻi maʻi urinarycystitis, pyelonephritis, urethritis),
• ʻōpū o ka pūpū (komo peritonitis),
• nā hopena o nā ʻōpala palupalu, nā kiko subutan a me ka ʻili o kahi ʻano purulent (e komo pū ana me nā ʻōpū, ke kuni. nā maʻi ʻeha),
• maʻi maʻi hepatobiliary
• nā hui pū ʻana a me nā iwi (komo osteomyelitis),
• nā lāʻau i hoʻopā ʻia
• nā hoʻopiʻi postoperative hoʻonā.

Nā hopena hopena

• Nā maʻi kūwaha: fiva, he wahi pehi, huu, angioedema.
• Hōʻuluʻulu pahuhopu ʻōnaehana: pālahalaha hyperbilirubinemiahoʻonoho transaminases hepatic, puale
• Nā hopena mai ka hematopoietic ʻōnaehana: leukopenia, granulocytopenia, anemia, thrombocytopenia.
• ʻO nā hopena mai ke ʻano o ka nūnū: kahi hoʻololi i ke neʻe ʻana o ka neuromuscular transmission, hiamoe, lie kanikela, ka pōʻino lohe (hiki i ke kuli ke hiki, nā pilikia o ka mea hana vestibular.
• Mai ka pae genitourinary: proteinuria, oliguria, microhematurianā mālamalama maikaʻi ʻole.

Nā ʻōkuhi no ka hoʻohana ʻana iā Amikacin (Ke ʻano a me ke ʻano)

Injections Amikacin kuhikuhi no ka hoʻohana hiki iā ʻoe ke lawelawe i ka lāʻau intramuscularly a i ʻole intravenously.

Kēia palapala i hana ʻia e like me nā papa no ka hoʻonaninani waha.

Ma mua o kahi paʻi, pono ia e hana i kahi hoʻokolohua intradermal no ka mākaʻikaʻi ʻana i ka lāʻau, inā ʻaʻohe contraindications no kāna hana.

Pehea e hoʻohapai ai iā Amikacin? Mākaukau kahi hopena o ka lāʻau lapaʻau ma mua o ka hoʻokele ʻana ma ka hoʻokomo ʻana i ka 2-3 ml o ka wai kolo i manaʻo ʻia no ka hiki ʻana i nā pona i loko o nā kiko o ke kō. Hoʻoponopono koke ʻia ka hopena ma hope o ka hoʻomākaukau ʻana.

ʻO nā kānana maʻamau no nā pākeke a me nā keiki mai hoʻokahi malama he 5 mg / kg ʻekolu mau manawa a hoʻokahi lā a i ʻole 7.5 mg / kg ʻelua i ka lā no 10 lā.

ʻO ka palena kiʻekiʻe loa i kēlā me kēia lā he 15 mg / kg, i hoʻokaʻawale ʻia i ʻelua inikua. Ma nā hihia koʻikoʻi loa a ma nā maʻi i hoʻomake ʻia e Pseudomonas, ua hoʻokaʻawale ka nui o kēlā me kēia lā i loko o ʻekolu mau hoʻokele. Pono ka hopena kiʻekiʻe ʻoi loa no ka papa holoʻokoʻa o ka mālama ʻana ma mua o 15 mau grama.

Kuhi mua ʻia nā pēpē 10 mg / kg, a laila e neʻe i ka 7.5 mg / kg no 10 mau lā.

Hoʻomaʻamaʻa ka hopena therapeutic i loko o nā lā 1-2, inā ma hope o 3-5 mau lā ma hope o ka hoʻomaka ʻana o ka hoʻomaʻamaʻa ʻana ʻaʻole i mālama ʻia ka hopena o ka lāʻau lapaʻau, pono e hoʻokuʻu ʻia a ua loli nā ʻano aʻoaʻo.

Ke keu

Nā hōʻailona: ataxialohe pio āhāhuʻe, makewai, hoʻohuihā ʻana aku o ka uwa, ka luaʻi, ka ʻōpū, ke tinnitus, ka maikaʻi ʻole o ka hanu.

Hoʻomaʻamaʻa: no ka hoʻōki ʻana i nā maʻi hoʻokele neuro-muscular hemodialysispaakai kalaiula, nā mea hana anticholinesterase, Hōʻailona hoʻoihoa me ka hoʻolaʻa hōʻailona.

Hoʻohui

Hiki ke hopena kūlohelohe Neprotoxic aʻo ka hoʻohana ʻana me vancomycin, amphotericin B, methoxyflurane,X-ray mea hoʻohālikelike, non-steroidal anti-inflammatory drug, enflurane, cyclosporine, cephalotin, cisplatin, polymyxin.

Hiki i ka hopena Ototoxic ke hoʻohana ʻia me ethacrylic acid, furosemide, cisplatin.

Ke hui pū me lākou penicillins (me ka pōʻino pale) i ka hopena antimicrobial.

Ke kaʻana me ka Nā lālani pale hao a etil eter nui ka hopena o ke kaumaha o ka hanu.

ʻAʻohe ʻae ʻia ʻo Amikacin e hui ʻia i ka hopena me ka cephalosporins, penicillins, amphotericin B, erythromycin, chlorothiazide, heparin, thiopentone, nitrofurantoin, tetracyclines, ʻona mai ka hui B, ascorbic acid a kaleka pālahalaha.

Hoʻolālā ʻAmelika ʻAmelika

Nā Huaʻōlelo: Amikacin sulfate (kapo no ka hoʻonā) Hoʻoikaika (inikopa) Amikacin-Kredofarm (kapo no ka hoʻonā) Loricacin (inikopa) Pleoplē (ke hoʻonā no ka hoʻonākiuki).

Ma muli o ke komo ʻole ʻana o ka poʻe āpau kaʻaoglikua ʻAʻole loaʻa nā mea hui pūliki ʻAikaka ma nā ʻōpū ma nā papa.

No nā kamaliʻi ma lalo o 6 mau makahiki i kau ʻia ma kahi mua he 10 mg / kg, a laila 7.5 mg / kg ʻelua i ka lā.

Nā hōʻailona Amikacin sulfate

ʻO ka maʻi ʻeha e hōʻeuʻeu i ka microorganisms mahele i ka lāʻau lapaʻau: sepsis, meningitis, peritonitis, septic endocarditis, mau maʻi a me ka maʻi ʻana o ka ʻōpū o ka ʻōpū o ka paepae (pneumonia, empyema pleural, ʻeha pūnaʻi), nā keiki a me nā maʻi o ka urinary, hopohopo a me ka pinepine ʻana (pyelonephritis, urethritis ʻoi (cystitis), nā mea i hoʻopā ʻia, etc.

ʻLoe a me ke kākele

Ka in m / i ni in / in (drip). ʻO nā pākeke a me nā wā'ōpiopio me ka hana renal maʻamau - 15 mg / kg / lā (5 mg / kg i kēlā me 8 mau hola a i ʻole 7.5 mg / kg i kēlā me kēia mau hola 12), nā keiki me kahi wai pākahi mua - 10 mg / kg, a laila 7.5 mg / kg i kēlā me kēia mau hola 12. ʻO ka nui o kēlā me kēia lā he 1.5 g, ʻo ka nui o ka papa ʻōlelo he ʻokoʻa ma mua o 15. He mau hopena, huli lākou e hana me ka lāʻau lapaʻau ʻē aʻe no nā lā 5. ʻO ka lōʻihi lōʻihi o ka mālamaʻana he 7-10 lā.

ʻO nā mea maʻi me ka hala ole kahi pono e hoʻemi i ka hoʻohaʻahaʻa ʻana a me ka hoʻonui ʻana o nā kikowaena ma waena o nā kāpena me ka ʻole e hoʻololi i hoʻokahi pae. Hoʻohālikelike ʻia ka manawa ma ka ʻano: the serum creatinine concentration x 9. ʻO ka maʻi mua loa no ka poʻe maʻi me ka hana ʻole ʻana o ka 7.5 mg / kg, no ka pane ʻana o nā hōkū ma hope e hoʻohana i ka ʻōmole: Cl creatinine (ml / min) x mua o ka inumua (mg) / Cl creatinine maʻamau (ml / min).

ʻO nā mea mālama palekana

I nā mea maʻi me ka hypersensitivity i nā aminoglycosides ʻē aʻe, e hoʻomohala paha kahi hopena cross-alika i ka amikacin. I ka wā e loaʻa mai ai nā hopena kūlohelohe, a kāpae ʻia ka lāʻau lapaʻau a kanu ʻia i lalo i ka diphenhydramine, ke kōpaʻa chloride, a me nā mea ʻē aʻe. Hoʻonui ka ʻike i ka pilikia o ka vestibular a me auditory me ka hana ʻole o ka renal. Hoʻonui nui ka hoʻonui ʻana o ka oto- a me ka nephrotoxicity me ka hoʻohana mau ʻana a me nā kaha kiʻekiʻe. I nā hōʻailona mua o ka poloka o ka hoʻokaʻomaʻo neuromuscular, pono e pani i ka hoʻokele ʻana o ka lāʻau lapaʻau a kāpae koke i ka hopena iv a me ka hopena o ka calcium chloride a i ʻole ka hopena sc o ka proserin a me ka atropine, inā pono, e hoʻoneʻe ʻia ka mea maʻi i ka hoʻokele hoʻohana ʻia.

Nā ʻōlelo kikoʻī

Ma mua o ka hoʻohana ʻana i ka lāʻau lapaʻau, pono e hoʻoholo i ka nānā ʻana o nā microorganisms i ka antibiotic (e hoʻohana i nā disk i loaʻa iā 30 μg o amikacin sulfate). Me kahi anana ākea o 17 mm a i ʻole, ua noʻonoʻo ʻia ka microorganism, 15-16 mm e hōʻona a maʻalahi, a ʻemi hoʻi ma mua o 14 mm mau. I ka wā o ka mālamaʻana, pono e nānā ʻia nā mea o ka antibiotik i ka plasma koko (ʻaʻole pono ka neʻe o ka ʻike i ka 30 μg / ml).

No ka hoʻokele i / m, ua hoʻohana ʻia kahi hoʻonā i hana ʻia ex tempore mai ka pauku lyophilized me ka hoʻohui ʻana o 2-3 ml o ka wai no ka maʻi ʻana i nā kiko o ka vial (250 mg a i ʻole 500 mg o ka pauka) e hoʻohana ʻia. No ka lūlū iv, e hoʻoheheʻe i 200 ml o ka hopena o ka glucose 5% o a i ʻole ka hopena 0.9% sodium chloride. Pono ka ʻike o ka amikacin i ka hopena no ka hoʻomake ʻana ʻo iv no ka 5 mg / ml.

Nā Hoʻohui

Hypersensitivity (e pili ana i ka mōʻaukala o nā aminoglycosides āpau), nā neuritis auditory, nā hopena renal koʻikoʻi me ka azotemia a me ka uremia, ka hapai. ʻO Myasthenia gravis, parkinsonism, botulism (aminoglycosides hiki i ka hoʻopiʻi ʻana i ka hoʻoili ʻana o ka hoʻoponopono neuromuscular, ka mea e alakaʻi hou ai i nā ʻuhane o nā kuʻuna), ka puʻuwai, ka hemahema ʻole, ka wā neonatal, ka wā kahiko o nā keiki, ka wā kahiko, ka lactation.

Pehea e hoʻohana ai: dosis a me ke ʻano o ka mālama ʻana

V / m, iv (i loko o kahi pahu, no 2 mau minuke a i ʻole ka wai), 5 mg / kg i kēlā me 8 mau hola a i ʻole 7.5 mg / kg i kēlā me kēia mau hola 12, nā maʻi maʻi bacterial o ka urinary tract (uncomplicated) - 250 mg i kēlā me kēia mau hola 12. ma hope o kahi hālāwai hemodialysis, hiki ke kuhikuhi i kahi nui o 3-5 mg / kg. ʻO ka palena loa ma mua o nā pākeke a hiki i ka 15 mg / kg / lā, akā ʻaʻole iʻoi aku ma mua o 1.5 g / lā no nā lā 10.

ʻO ka lōʻihi o ka mālamaʻana me kahi / i ka hoʻomakaʻana he 3-7 mau lā, me kahi / m - 7-10 lā.

No nā pēpē mua, ʻo ka pae mua ka 10 mg / kg, a laila 7.5 mg / kg i kēlā me kēia mau hola 18-24, no nā pēpē hou, ʻo ka hopena mua loa he 10 mg / kg, a laila 7.5 mg / kg i kēlā me kēia mau hola 12 no 7-10 mau lā.

ʻO nā mea maʻi me ka pani ʻole ʻana e koi ai i ka hoʻoponopono ʻana o ka hoʻoponopono dosage.

ʻO nā mea maʻi me nā puhi kuni e koi i kahi kaila o 5-7.5 mg / kg i kēlā me kēia mau hola 4-6 ma muli o ka T1 / 2 (1-1,5 hola) i kēia mau maʻi.

No ka ʻulaʻina i / m, kahi hoʻohana i hoʻomākaukau ʻia i kahi tempore mai kahi pauku lyophilized me ka hoʻohui ʻana o 2-3 ml o ka wai no ka maʻi ʻana i nā kiko o ka ipu (0.25 a 0.5 g o ka pauka paha) e hoʻohana ʻia. No ka mea i / v mea hoʻokele, ua like nā hopena like ʻole i ka i / m, ma hope o ka hoʻoheʻe ʻana iā lākou me 200 ml o ka hopena o 5 dexrose 5% a i ʻole 0.9% hopena o NaCl. Pono ka ʻike o ka amikacin i ka hopena no ka hoʻomake ʻana ʻo iv no ka 5 mg / ml.

Ka hana lāʻau lapaʻau

ʻO nā Semi-synthetic ākea ākea-spacric antibiotic, bactericidal. Ma ka paʻa i ka 30unit subunit o ka ribosom, e pale i ka hoʻokumu ʻana o kahi limahana o ka halihali a me ka mea hoʻouna aku RNA, poloka ka synt synthesis, a e hoʻopau pū i ka membrane cell bacteria.

Ka hana ikaika i ka microorganism aerobic gram-hewa - Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp., Serratia spp., Providencia spp., Enterobacter spp., Salmonella spp., Shigella spp., Kekahi mau micro-positive microorganisms - Staphylococcus. (me ke kū'ē i ka penicillin, kekahi mau cephalosporins),

hana kūlike e kūʻē Streptococcus spp.

Me ka hoʻokolohua ʻōwili ʻana me ka benzylpenicillin, loaʻa iā ia kahi hopena synergistic kūʻē Enterococcus faecalis strains.

ʻAʻole pili i ka microorganisms anaerobic.

ʻAʻole i nalowale ka Amikacin hana i lalo o ka hana a nā enzymes e hana i ka aminoglycosides e hiki ai, a hiki ke hoʻomau i ka kūʻē i ke aho o Pseudomonas aeruginosa pale i ka tobramycin, gentamicin a me ka netilmicin.

Nā mea hana like:

• ʻO nā papa maʻamau a Augmentin (Augmentin)
• ʻO Augmentin Powder no ka hoʻopiʻi ʻana i ka waha
• Orzipol (ORCIPOL) nā papa waha
• Dioxidin (Dioxydin) Mouthwash
• Tsifran OD (Cifran OD) Nā papa poʻo
• Hoʻomaka (Gentamicin) maʻi maʻi
• ʻO nā Papa Amoxicillin Sandoz (Amoxicillin Sandoz) Nā Pihi
• ʻO Augmentin EU (Augmentin ES) Powder no ka hopena o ka waha
• Kāhea ʻia ʻo Aerosol
• Hiconcil Capsule

** ʻO ke kuhikuhi ʻana i ka hana lapaʻau no nā ʻike ʻike wale nō. No ka ʻike hou aku, e kiʻi i ka annotation a nā mea hana. Mai hoʻolaʻa ponoʻī iā ʻoe ma mua o kou hoʻomaka ʻana i ka hoʻohana ʻana iā Amikacin Sulfate, pono ʻoe e kamaʻilio i ke kauka. ʻAʻole kuleana ʻo EUROLAB no ka hopena i hoʻoiho ʻia e ka ʻike o ka ʻikepili i hōʻike ʻia ma ka waihona. ʻAʻole hoʻohuli nā ʻikepili ma ka pūnaewele i ka ʻōlelo aʻo a ke kauka a ʻaʻole hiki ke lawelawe me ka hōʻoia ʻana o ka hopena maikaʻi o ka lāʻau.

Keʻae nei ʻoe i ka makemake ma Amikacin Sulfate? Makemake ʻoe e ʻike i nā ʻikepili hou aʻe a makemake paha e ʻike i ke kauka? A i ʻole makemake paha ʻoe i ka hoʻokolokolo? Hiki iā ʻoe e hana me ke kauka - Lūkini Euro labepela mau i kāu lawelawe! E nānā nā kauka maikaʻi iā ʻoe, e aʻo aku, e hāʻawi i ke kōkua e pono ai a hana i kahi maʻi maʻi. Hiki iā ʻoe ke kāhea i ke kauka ma ka home. ^ E Ha yM. Klinika Euro labepela wehe iā ʻoe a puni ka uaki.

** Manalo! ʻO ka ʻike i hōʻike ʻia i loko o kēia alakaʻi lāʻau i manaʻo ʻia no nā mea lapaʻau a ʻaʻole pono ia i kumu no ka lāʻau lapaʻau ponoʻī. Hāʻawi ʻia ka wehewehe ʻana o ka lāʻau lapaʻau ʻAikake Amikacin no ka haʻi ʻana a ʻaʻole i manaʻo ʻia no ke koho ke ʻano o ka mālama ʻana me ka ʻole o ka komo ʻana i kahi kauka. Pono ka poʻe maʻi i nā ʻōlelo aʻo kikoʻi!

Inā makemake ʻoe i nā lāʻau āpau a me nā lāʻau lapaʻau, ko lākou wehewehe a me ka ʻōlelo pili no ka hoʻohana ʻana, ka ʻike e pili ana i ka haku ʻana a me nā puka o ka hoʻokuʻu ʻana, nā hōʻailona no ka hoʻohana a me nā hopena ʻaoʻao, nā hana o ka hoʻohana ʻana, nā kumukūʻai a me nā loiloi o nā lāʻau lapaʻau, a i ʻole ia he mea. mau nīnau a me nā manaʻo - e kākau iā mākou, e hoʻomaʻamaʻa mākou e kōkua iā ʻoe.

Loaʻa ka hopena

Me ka hoʻohana lōʻihi ʻana a i ʻole overdose o amikacin sulfate hiki i kahi hopena oto- a me ke nephrotoxic. Hōʻike ʻia nā hopena o ka ototoxic amikacin sulfate i ke ʻano o ka lohe ʻana i ka hopena (hōʻemi ka ʻike ʻana i nā moʻo kiʻekiʻe) o nā pilikia o ka vestibular apparatus (dizziness). Hoʻonui ka ʻike i ka pilikia o ka vestibular a me auditory me ka hana ʻole o ka renal. Hōʻike ka nephrotoxic amikacin sulfate i ka hoʻonui nui ʻana i ke koena o ke koena o ka nui o ke koko, he hōʻemi i ka hoʻomaʻemaʻe ʻana o ka mea hana ma loko, inā paha me guria, protein uria, cylindruria a me nā kuʻuna.

hōʻano ʻē. I mea e pale ai i nā hōʻeha a hoʻemi i ka piʻi o kā lākou hoʻomohala, ʻōlelo ʻia ka lāʻau lapaʻau e hoʻohana ʻia ma lalo o ka hoʻomalu o ka ʻōpū, hoʻolohe a me nā hana apopo vestibular (ma kahi o hoʻokahi manawa i ka pule).

ʻO kahi ala hoʻohālikelike nui loa he neuromuscular blockade. Kokoke ke kīʻaha ʻana o kēia hopena i nā hana a nā mea hoʻonaninani o ka hopena antidepolarizing. I nā hōʻailona mua o ka hoʻokalakupua o ka hoʻouluʻana neuromuscular, pono e pani i ka hoʻokele ʻana o ka sulfik amikacin a hoʻokō koke i nā hopena o ka calcium chloride a i ka hopena o ka subcutaneous o proserin a me ka atropine. Inā pono, e hoʻololi ka mea maʻi i ka hanu mana ʻana.

Ke hoʻohana ʻia i ka lolo amikacin, hiki i nā hopena alia ke ʻano (hiki i ka ʻāʻī o ke kino, ke ʻano, ʻeha, ʻeha, a me nā mea āpau). I ka wā e ʻike ʻia ai, kāpae ʻia ka lāʻau lapaʻau a hoʻonoho ʻia nā lāʻau lapaʻau (diphenhydramine, calcium chloride, etc.). Me ka hoʻokele intravenous o kahi lāʻau maʻi, hiki i ka hoʻomohala ʻana o ka phlebitis a me nā periphlebitis.

Nā nīnau, pane, nā manaʻo kūkā i ka lāʻau lapaʻau Amikacin sulfate

ʻO ka ʻikepili i hāʻawi ʻia e hana no nā lāʻau lapaʻau a me nā lāʻau lapaʻau. Aia nā ʻike e pili ana i ka lāʻau lapaʻau e pili ana i nā ʻōlelo i hoʻopili ʻia e ka mea hoʻopiʻi e ka mea hana.ʻAʻohe ʻikepili i hoʻopili ʻia ma kēia a ʻole kekahi ʻaoʻao o ka pūnaewele a mākou e hiki ke lawelawe ma kahi kūʻokoʻa no ka hoʻopiʻi pilikino i ka loea.