Nā hopena o ka hoʻohana ʻana i ka Captril-AKOS i ka maʻi diabetes

Creensril-AKOS: nā ʻōlelo no ka hoʻohana ʻana a me nā loiloi

Palapala Latin: Creensril-AKOS

ATX Code: C09AA01

ʻO ka mea kūpono: captopril (Creensril)

Mea Hana: Synthesis, Open Society (Russia)

Hoʻouka i ka wehewehe a me ke kiʻi: 11/30/2018

ʻO nā kumukūʻai ma nā lāʻau lapaʻau: mai 10 mau rubles.

ʻO Cucksril-AKOS kahi mea hoʻomehanaʻelima-angiotensin (hoʻololi i ka enzyme), kahi lāʻau antihypertensive.

E hoʻokuʻu i ke ʻano a me ka ʻano

Loaʻa ka lāʻau lapaʻau i ke ʻano o nā papa: ʻāpala-cylindrical, me kahi chamfer, kokoke i ke keʻokeʻo a i ʻole ke keʻokeʻo paha, loaʻa ke ʻano ʻonaʻawa, ʻae ʻia ka hoʻoweliweli, ʻokoʻa ka hoʻokaʻawale o ka hoʻokaʻawale ʻana i nā papa i kahi papa o 50 mg (dosage o 25 mg: 10 a 25 pcs. , ma nā pahu kīwila o 1, 2, 3 a i ʻole 4 mau pā, i ka pā o ka 50 mg: 10 a i 20 mau pcs i nā blisters, i loko o kahi pūpū kāleka o 1, 2, 3, 4 a i ʻole 5 mau pā, 10, 20, 30, 40 , 50, 60, 80 a i ʻole 100 pcs. I nā paʻomo poli, i loko o ka pahu pahu pepa 1 hiki, iā kēlā me kēia pū ka pahuhopu e pili ana i ka hoʻohana 'ana o ka captopril-ICCO).

Pākaukau 1 papa:

mea hana ikaika: captopril (ma hua ʻōlelo o ka kau maloʻo) - 25 a 50 mg,
ʻO nā mea kōkua: dosage 25 mg - starch corn, milk milk, magnesium stearate, talc, dosage 50 mg - lactose monohydrate (waiu waiu), colloidal silicon dioxide (aerosil), cellulose microcrystalline, crospovidone (CL-M collidone, CL collidone), magnesium stearate, talc.

Lapaʻau lāʻau

ʻO Creensril-AKOS ka lāʻau antihypertensive, ka hana o ka hana ma muli o nā waiwai o ka mana hana - captopril. ʻO Creensril kahi mea paʻa o ACE mua huaʻāina nona ka pūʻulu SH (pūʻulu sulfhydryl). Ma ka paleʻana i ka ACE, e hōʻemi ana i ka huli ʻana o ka angiotensin I i ka angiotensin II a hoʻohemo i kāna hopena vasoconstrictor ma nā moku venous a me ka arterial. ʻO ka emi ʻana o ke kaina o ka angiotensin II e hoʻolōʻihi i ka hoʻonui hou ʻana i ka hana o ka plasma koko renin, e hōʻemi ana i ka hoʻokaʻawale ʻana i ka mea huna o ka ald testosterone e ka adrenal cortex. Hoʻopilikia kēia i kahi emi o ka pale kūloko o peripheral (OPSS) a me ke kahe o ke koko (BP), ke kūpaʻa ʻana i nā moku pulmonary, a me ka kaila o ka mua a ma hope o ka hapaha o ka naʻau. Hoʻonui ʻia nā hopena cardiac, hoʻomanawanui.

Ma lalo o ka hopena o ka captopril, e hoʻonui ai i nā lāʻau i kahi ʻoi aku ka nui ma mua o nā veins. Pēlā nō hoʻi, e lawe aku nei i Creensril-AKOS i ka nui o ka syntaglandin synthesis a me ka hoʻohaʻahaʻa ʻana i ka hōʻemi o ka bradykinin.

ʻAʻole ka hilinaʻi i ka hopena antihypertensive o ka captopril i ka hana a ka plasma renin. ʻO kona hopena ma ka kiko renin-angiotensin-aldosterone system (RAAS) e hoʻolohi ai i ka emi ʻana o ke koko i ka wā o ka hana maʻamau a hoʻemi i ka hana hormone.

Hoʻonui ka Cucksril i ke kahe coronary a me ka kahe koko, hoʻomaikaʻi i ka hāʻawi ʻana i ke koko i ka myocardium ischemic. ʻO kona hoʻohana lōʻihi loa ka mea e hōʻemi ai i ka nui o ka hypocrial myocardial a me nā paia o nā arai resistive, e pale ai i ka holomua o ka puʻuwai puʻuwai, a ke pale aku nei i ka hoʻomohala ʻana o ka dilateation o ka ventricular hema.

ʻO ka lawe ʻana iā Cebookril-AKOS i ka hōʻemi i ka hoʻohui ʻana o platelet, i ka puʻuwai puʻuwai - i ka hoʻolilo ʻana o nā kiko o nā sodium ion.

ʻO ka hōʻemi ʻana i ka tonus o ka effterent arterioles o ka glomeruli o nā pūpū e kōkua i ka hoʻomaikaʻi i ka hemodynamics intracubular a pale i ka helehelena o nā nephropathy diabetes.

I loko o kēlā me kēia lā o 50 mg, hōʻike ka captopril i nā waiwai angioprotective e kūʻē i nā moku koko o ka microvasculature. I nā maʻi me ka nephroangiopathy maʻi maʻi, e hōloi ana i ka holomua o ka hiki ʻole o ka maikaʻi ʻole o ka renal ʻole.

ʻAʻole e like me nā vasodilators pololei, e like me ka hydralazine a me ka minoxidil, kahi kaila o ke koko i ka wā e lawe ana iā Captopril-AKOS ʻaʻole i ukali ʻia e ka tachycardia reflex a kōkua i ka hoʻēmi ʻana i ka makemake oxygen myocardial. Loaʻa nā dosis kūpono o ka captopril i nā maʻi me ka hoʻopiʻi ʻana i ka naʻau ʻaʻole pili i ke koko.

Ma hope o ka lawelawe waha, ua hōʻemi nui ʻia ka nui o ke kahe ana o ke koko i nā hola 1-1.5. ʻO ka lōʻihi o ka hopena hypotensive e hilinaʻi i ka maʻa i lawe ʻia; a hiki i kona waiwai nui ma hope o nā hebedoma o ka lapaʻau.

ʻAʻole hiki iā ʻoe ke wehe wehe i ka captopril, hiki i kēia ke alakaʻi i kahi hoʻonui nui o ke koko.

Lapaʻau lāʻau

Ma hope o ka lawelawe waha, ua hele mai kahi wikiwiki o ka 75% o ka nui o ka nui o Cadedril-AKOS i lawe ʻia. ʻO ka inu ʻana o ka meaʻai me ka hoʻoneʻe ʻana i ka mālama ʻana o captopril e 30-40%. I ka hoʻomaka mua ʻana ma o ka ate, 35–40% o ka hana ikaika he biotransformed. Ka hoʻokūkū nui (C_max) i ka kō koko koko i loaʻa i loko o nā hola 0.5-1,5 a he 114 o ka / ml.

Hoʻohālikelike i nā protein plasma koko - 25-30% (nui me ka albumin).

ʻO ka lanakila o ke koko-lolo a me ka papa lāʻau no ka wahi liʻiliʻi ma lalo o kahi liʻiliʻi (liʻiliʻi loa i ka 1%). Me ka waiū umauma, a hiki i ka 0.002% o ka hopena i lawe ʻia ʻia.

Hoʻonohonoho ka Creensril i ka pūpū me ka hoʻokumu ʻana o nā metabolite hoʻonaninani kūlohelohe - captopril disulfide dimer a me ka captopril-cysteine sulfide.

Half-ola (T_1/2) captopril ma kahi o 2-3 mau hola. Ma kahi o 95% o ka loaʻa i koho ʻia e excreted ma o ke keiki i ka manawa o 24 mau hola mua (me ka 40-50% loli ʻole).

I loko o ka hana ʻole i ke kōkā maʻi, hōʻuluʻulu ka lāʻau, T_1/2 hiki i waena o 3.5 a 32 mau hola. ʻO nā mea maʻi me ka hana renal impaired e hoʻemi i ka hoʻokahi pākahi a / a hoʻonui i ke kikowaena ma waena o nā pona o Captopril-AKOS.

Nā hōʻailona no ka hoʻohana ʻana

hypertension arterial (me ka hypertension renovascular),
ka maʻi paʻakikī ʻole - ma ke ʻano he hōʻuluʻulu paʻakikī,
hana ole o ka ventricle hema ma hope o ka infocoction myocardial i loko o nā mea maʻi i kahi kūlana paʻa.
nephropathy maʻi maʻi i ke ʻano maʻi mellitus type 1 (albuminuria ma mua o 30 mg / lā).

Nā Hoʻohui

Dure function renal, bilateral renal stenosis stenosis, hoʻokahi keiki stenosis me ka azotemia holomua, ʻo ka hyperkalemia refractory, hyperaldosteronism mua, ʻano ma hope o ka hoʻololi ʻana o ka pēpē,
lima hana hoʻopili hewa,
ka hoʻohana like ʻana o aliskiren a me nā mākaʻi o aliskiren i loko o nā mea maʻi me ka type type diabetes 2 mellitus a i nā mea maʻi me ka hana ʻole o kahi maʻi i hana ʻia me ka creatinine clearance (CC) ma lalo o 60 ml / min.
lolika lactose, maʻi pākuʻi glucose-galactose malabsorption a puʻuwai lactase,
wā hāpai
hana waiū
makahiki i 18 makahiki
hoʻoilina a me / a i ʻole angioedema idiopathic e pili ana i ke kumu o ka lāʻau o ka mua me ka ACE inhibitors (me ka mōʻaukala),
hypersensitivity i kekahi ACE inhibitors, me ka mōʻaukala
ka maʻi kūlohelohe o nā mea āpau o ka lāʻau lapaʻau.

Me ka mālama aka, pono e kau ʻia nā papa ʻehās-AKOS no hypertrophic obstructive cardiomyopathy, maʻi ʻeha coronary, mitral stenosis, aortic stenosis a me nā loli like ʻole e hōʻemi i ke kahe o ke koko mai ka palena hema o ka puʻuwai, i ka hopena o ka hypovension hypertension, maʻi renal failed, systemic lupus erythematosus maʻi hui ʻeha, pale ʻana i ka hematopoiesis pumehana o nā iwi, nā pathologies cerebrovascular, ka maʻi diabetes, mellitus, hyperkalemia, maʻiʻa. hana ate, ʻaina paʻa o ka sodium chloride, hemodialysis, ʻeha, maʻiʻaʻi, a i ʻole nā ʻano ʻē aʻe e hoʻolilo ai i ka hoʻokahe nui o ke koko i ka wā o ka hōʻola a i ʻole anesthesia aoao, hemodialysis e hoʻohana ana i nā membanes holo kiʻekiʻe (e komo pū ana me AN69 polyacrylonitrile kiʻekiʻe-nā membranes), conensitant desensitizing therapy, apheresis o lipoproteins haʻahaʻa haʻahaʻa (LDL), i ka hui pū me nā diuretics pākia-kalima, ka hoʻomākaukau ʻana i ka paʻakai, nā mea pili i ka paʻakai a me ka paʻakai, ka hoʻomākaukau lithium, nā mea maʻi o ka lāhui Negroid, i ka wā kahiko.

Nā hopena hopena

ʻO nā pilikia ʻole i ka ʻōpū o nā ʻōnaehana a me nā ʻōpala (e like me ke alapō ʻana o kā lākou hoʻomohala ʻana, ua helu ʻia i kēia: pinepine pinepine - ≥ 1/10, pinepine - ≥ 1/100 a me 9 i ka 1 pāloli e hoʻokaʻawale ai i kahi hōʻike koko, ma lalo o 1 x 10 9 i ka 1 lita - ka lāʻau lapaʻau Inā loaʻa nā hōʻailona o nā maʻi maʻi maʻi, me ka ʻehaʻeha a me ke kūlohelohe paha, loaʻa i kahi hōʻike koko lapaʻau me kahi helu leukocyte.

Pono e noʻonoʻo i ka lawe ʻana iā Creensril-AKOS i ka hope o ka desensitizing therapy me ka hymenoptera venom a me nā mea like me ka hoʻonui i ka hopena o ka hopena anaphylactoid.

Ma ka hihia o ka nui o ka hana o ka transaminases hepatic a i ʻole ka hiʻohiʻona o nā hōʻailona jaundice, e hoʻopau koke ʻia ka mālama ʻana me ka captopril.

I loko o nā kānaka o ka lāhui Negroid, ka ACE inhibitors, me Creensril-AKOS, hōʻike i ka hopena antihypertensive liʻiliʻi.

ʻO kahi hōʻike urine no ka acetone i loko o nā poʻe maʻi e lawe nei i ka lāʻau lapaʻau hiki ke hāʻawi i kahi hopena maikaʻi ʻole.

ʻŌpū a me ka lactation

Hoʻopili ʻia ka hoʻohana ʻana o Creensril-AKOS i ka wā gestation a me nā hōʻuluʻulu umauma.

ʻO nā wahine o nā keiki hānau keiki e hoʻolālā nei i ka wā hapai e pale i ka hoʻohana ʻana o nā mea paʻa o ka ACE (me ka captopril). Pono lākou e hoʻolako i nā lāʻau antihypertensive hou.

Inā hele kuhi ʻia i ka wā o ka hoʻokele ʻana o Creensril-AKOS, hiki koke ke kāpae ʻia a koi ʻia ka nānā pono ʻana i ka hoʻomohala ʻana i ka ʻōpiopio. ʻO ka hoʻohana ʻana i ka captopril i ka mea hoʻomaʻama mua o ka hānau ʻana i hiki ke hoʻonui i ka ulu ʻana o ka ulu ʻana o ka hānau ʻana i ka hānau keiki. ʻO ka hoʻohana lōʻihi ʻana i ka lāʻau i loko o ka mea hōʻiliʻili o ka II a me III i mea hoʻopailua i ka ʻōpū a alakaʻi i ka hoʻoiho ʻana i ka pīpī ʻana o nā iwi o ka iwi, hōʻemi ʻia ka hana ʻula, oligohamoamnios, ua manaʻo ʻia e loiloi i ke ʻano o nā iwi ʻōpala a me ka hana o ka hana ʻana i ka wahine lā ma ka ultrasound (ultrasound).

I loko o nā pēpē i hala mau keiki nā poʻe e lawe aku i ka captopril i ka wā nui a me ka poʻe trimesters II a me III o ka hāpai ʻana, hiki i ka hoʻomohala ʻana o ka hiki ʻana o ka renal nealatal, hyperkalemia, hypotension.

Me ka hana pūnāwai paʻa ʻole

ʻO ka hoʻohana ʻana o Captopril-AKOS no ka mālamaʻana i nā poʻe maʻi me ka hōʻeha ʻana i ka maʻi papalapa ʻole e like me ka stenosis bilateral renal stenosis, stenosis hoʻokahi keiki me ka azotemia holomua, ʻo hyperkalemia refractory, hyperaldosteronism mua, a me ke ʻano ma hope o ka hoʻololi ʻana i ka maʻi lā.

Me ka makaʻala, pono ke kau ʻia o ka captopril i nā maʻi me nā pilikia ʻoi ʻole.

Me ka haʻahaʻa haʻahaʻa o ka hana renal i ʻole ke kau (CC 30 ml / min a ma luna), hiki ke kuhikuhi ʻia iā Calaopala-AKOS i loko o kēlā me kēia lā o 75-100 mg.

Me ka hopena o ka renal kino (CC ma mua o 30 ml / min), ʻaʻole pono ka nui o ka lā ma mua e pili ana i ka 12.5 mg. Inā pono, hiki ke hoʻonui iki ʻia ka nui, e nānā ana i nā wā lōʻihi, akā ʻoi aku ka nui o ka hoʻoponopono mālama ʻia ma mua o ka hopena maʻamau e hoʻohana ai i ka hypertension arterial.

ʻOi paha ka pahuhopu hou o ka "loop" diuretics, akā ʻaʻole ia o ka diuretics o ka moʻolelo thiazide.

E hoʻoponopono ʻia ka hoʻoponopono ʻia o ka hoʻoponopono ʻia ʻana e hana ʻia ka hana ʻōmaʻomaʻo i ka mea nānā i ka mālama ʻana i ka QC o ka mea maʻi i kēia mau ʻōlelo aʻe:

CC 40 ml / min: ʻo ka inanele mua loa he 25-50 mg, ʻo ka nui loa ma mua o kēlā me kēia lā he 150 mg,
KK 21-40 ml / min: ʻo ka mua ka nui o kēlā me kēia lā he 25 mg, ka nui o ka nui o kēlā me kēia lā he 100 mg,
KK 10-20 ml / min: kahi mua o kēlā me kēia lā he 12.5 mg, ʻo ka nui loa o ka lā helu he 75 mg,
ʻOi aku ka QC ma mua o 10 ml / min: ʻo ka nui o ka lā ma mua o 6.25 mg, ʻo ka nui loa ma mua o ka lā he 37.5 mg.

Hoʻohana i ka wā kahiko

Pono e hāʻawi ʻia ka makaʻala e hopu i ka captopril-AKOS i nā maʻi maʻi maʻi.

ʻO ka lāʻau hoʻomaka no nā poʻe maʻi maʻi he 6.25 mg 2 mau manawa i ka lā. Hāpai kēia regimen dosing i ka hana renal impaired, no laila ʻike ʻia ia he maikaʻi no ka maʻi mālama. Manaʻo ia e hoʻoponopono i ka hapa o Creensril-AKOS e noʻonoʻo mau i ka pane o ka lāʻau lapaʻau maʻamau, mālama pono ʻia ma ka pae haʻahaʻa haʻahaʻa.

Hoʻohui nūhou

angiotensin II antagonist receptor (ARA II), aliskiren a me nā lāʻau lapaʻau ʻē aʻe e pili ana i ka RAAS: hoʻonui i ka nui o ke kuhi ʻana i ke koko, puhaluhi āpau o nā pūlea (me ka nui o ka moloka plula), hyperkalemia. Ma kēia mea, inā pono, ʻo ka koho ʻana i nā lāʻau ʻē aʻe e pili ana i ka RAAS e pono e kiaʻi pono i ka neʻe koko, nā hōʻailona o ka hana renal, nā electrolytes plasma. Me nā hana pūlea paʻa ʻole a me ka type 2 diabetes mellitus, pono e pale ʻia me ka aliskiren,
Diuretics pākaʻi paʻilima (amiloride, triamteren, spironolactone, eplerenone), mākaukau pākui, hoʻouka paʻakai, hoʻonoho paʻakai: hoʻonui i ka pilikia o ka hyperkalemia, pono e kāohi i ka manaʻo o ka pākela piliola,
diuretics (thiazide a "loop"): i nā kiʻekiʻe nui e hoʻonui i ka hopena o ka hypotension arterial,
diuretics, hoʻāla manawa, aldesleukin, alprostadil, cardiotonic, alpha₁-locksers, beta-blockers, kikowaena alpha₂-adrenomimetics, lohi nā kaaniani kalepa hāpau, nitrates, minoxidil, vasodilators: potentiate ka hopena hypotensive o Creensril-AKOS,
nā lā hiamoe, antipsychotics, anxiolytics, antidepressants: hoʻoikaika i ka hopena antihypertensive o ka captopril,
Non-steroidal anti-inflammatory drug (NSAIDs), including indomethacin, selector cyclooxygenase-2 inhibitors, estrogens: me ka hoʻohana lōʻihi, hoʻemi lākou i ka hopena o captopril. Eia kekahi, ʻo ka hui pū ʻana o nā NSAIDs a me ACE inhibitors hiki i ka hopena hoʻohui i ka hoʻonui ʻana i ke kao o ka paʻakai serum e kūleʻa ana i ke ʻano o ka hoʻohaʻahaʻa ʻana i ka hana renal (e komo pū ana ka hopena o ka renal), ʻo ia hoʻi i nā mea maʻi me ka mōʻaukala o ka hana renal i ʻole ke alo o ka maʻi, nā mea maʻi, a i ʻole me ka hoʻēmi ʻia ʻana o ke kahe koko. ,
anesthesia aoao: kahi hoʻohaʻahaʻa i hoʻemi ʻia ke koko i ka wā o ka hana nui, hiki i ka mea, inā he anesthesia aoao he hopena antihypertensive,
Hoʻomoe lithium: ua iho ka lithium excretion a me kona hoʻomohala i loko o ke koko,
allopurinol, procainamide: piʻi nui ka pilikia o ka neutropenia a / a i ʻole he maʻi Stevens-Johnson,
glucocorticosteroids, epoetin, estrogens a me nā hui kūlohelohe waha, naloxone, carbenoxolone: hoʻonāwaliwali i ka hana a Creensril-AKOS,
Hoʻomake gula: iv ka hoʻokele ʻana o ka sodium aurothiomalate hiki i kahi mea paʻakikī o nā hōʻailona i ka mea maʻi, me ka hoʻokaʻawale ʻana i ke koko, ka ʻula helehelena, ka lua, ka luaʻi,
nā maʻi ʻolima: e hoʻemi i ka hopena haumania o ka captopril,
nā mea hoʻonā hypoglycemic no ka hoʻokō waha, insulin: hoʻonui i ka nui o ka hypoglycemia,
antacids: hoʻolōʻihi i ka laweʻana o ka captopril i ka gastrointestinal tract,
ethanol: hoʻonui i ka hopena hypotensive o Creensril-AKOS,
probenecid: kōkua i ka hoʻēmi ʻana i ka hoʻomaʻemaʻe kino o ka captopril, i alakaʻi ai i kahi hoʻonui i loko o ka neʻe i ka serum,
azathioprine, cyclophosphamide: hoʻonui i ka hiki o ka hoʻomohala ʻana i nā maʻi hematological,
propranolol: hoʻonui ʻia kona bioavailability,
cimetidine: kōkua i ka hoʻonui ʻana i ka manaʻo o ka mea hana i ka plasma koko,
clonidine: hōʻemi i ka nui o ka hopena antihypertensive.

The analogues of Captopril-AKOS are: Captopril, Captopril-Ferein, Captopril-FPO, Creensril-UBF, Creensril Velfarm, Kapoten, Katopil, Epsitron, Alkadil, Angiopril-25, Blockordil, Vero-C64aj, C64ril-STI a me nā mea ʻē aʻe.

Nā hana hana i ka hana

Hōʻike ka hōʻike ma lalo nei i ka hopena o kahi inhibitor ACE ma ʻelua mau ʻōnaehana hoʻololi:

ʻO ka hana o ka hoʻokumuʻana o ka angiotensin II, kahi hoʻemi i kona neʻe i loko o ke koko.
ʻO ka pale o ka luku ʻana o ka bradykinin i nā neʻe pale, ʻo ia ka mea e hāʻawi ai i kāna hōʻiliʻili ʻana

Kahi o ka hopena o kahi inhibitor ACE ma ʻelua ʻōnaehana hoʻololi

I ka paneʻana i kahi kahe o ke kahe koko a i ʻole ke kaumaha koʻikoʻi, hoʻomaka ka peptide renin e hoʻokuʻu i nā keiki ma hope. Hoʻokomo ia i ka protein angiotensinogen a hoʻololi ia i ka angiotensin I. I ka huli ʻana, ua lilo ʻo ia i ka angiotensin II me ke kōkua o ka angiotensin-hoʻohuli o ka enzyme. Ua kapa ʻia ke ʻano holoʻokoʻa o ka renin-angiotensin-aldosterone (RAAS).

ʻO Angiotensin II kēia mau waiwai:

ho'ēmi i nā musika o nā paia o nā kīʻaha koko, e hoʻopili i ka lumen. Hoʻopuka kēia i kahi hoʻonui i ke koko, e hoʻonui ana i ka luhi i ka puʻuwai, hoʻonui i ke kahe o ke koko i nā kino o loko,
hoʻonui i ke kao o aldosterone. Ma ka maʻi testosterone, e hoʻonui ai i ka nui o ke kahe i loko o ke kino. Ke alakaʻi nei kēia i ka edema a me ke kaumaha hou i ka ʻōnaehana cardiovascular. No kēia, aldosterone i loko o nā ʻaliki e hoʻoneʻe i ka sodium a hoʻoneʻe i ka paʻakai,
paipai ia i ka hoʻohuihui ʻana o nā mea like ʻole a me nā cylamine. Hoʻopau lākou a hoʻomaikaʻi aku i ka sclerosis o nā paia o nā kīʻaha koko, cardiac a me ka aʻalā.

Ma kahi o RAAS, ua pale aku ka ACE i ka ʻōnaehana kinin-kallikrein. ʻO Bradykinin ke kuleana no ʻelua mau papa hana:

hoʻomaha ʻana o nā pili koko, i.e. ka hoʻohaʻahaʻa ʻana i ke ʻano,
nā hopena maʻi a me nā maʻi maʻi.

ʻLoe a me ke kākele

Hoʻokele ʻia ka Creensril-AKOS i ka hola 1 ma mua o kahi pāʻina. Hoʻonohonoho ʻia ka ʻākena dosage hoʻokahi. I ka hoʻohālikelike ʻana i ka mahele o ka captopril e like me ka hōʻike ʻana i hōʻike ʻia, pono e hoʻohana i ka captopril i loko o ke ʻano maʻi: papa o 12.5 mg.

Me ka hypertension arterial, hoʻomaka ka mālama ʻana me ka maʻa haʻahaʻa loa o 12.5 mg 2 mau manawa i kahi lā (loaʻa pinepine me 6.25 mg 2 mau manawa i ka lā). Pono e uku ʻia i ka ʻomaʻomaʻi o ka hopena mua ma ka hola mua. Inā ulu ka hypotension arterial i kēia hihia, pono e neʻe ka mea maʻi i kahi kūlana (ʻo kahi pane i ka hopena mua ʻaʻole e lilo i mea pilikia i ka hana hou ʻana). Inā kūpono, e lūlū ka hopena (me kahi manawa o nā hebedoma 2-4) a hiki i ka hopena maikaʻi loa. Me ka hypertension arertial maʻalahi paha, ʻo ka lāʻau mālama mālama maʻamau ʻo 25 mg 2 mau manawa i kahi lā, ʻo ka nui loa ka nui o 50 mg 2 mau manawa i ka lā. Ma ka maʻi hypertension arterial, ʻo ka nui loa ka nui o 50 mg 3 mau manawa i ka lā. ʻO ka dosis kiʻekiʻe loa ʻo kēlā me kēia lā he 150 mg.

I nā poʻe maʻi ʻelemakule, ʻo ka hopena mua loa he 6.25 mg 2 mau manawa i ka lā.

I ka hopena o ka puʻuwai paʻakikī, ua kuhikuhi pū ʻia me ka diuretics a me / a i ʻole me ka mākaukau digitalis (i mea e pale aku ai i ka emi nui o ke kahe koko, hoʻopau ʻia ka diuretic a hoʻemi ʻia ka hāmeʻe ma mua o ka hoʻokō ʻana o Creensril-AKOS). ʻO ka dosis mua he 6.25 mg a i ka 12.5 mg 3 mau manawa i ka lā, inā pono, e hoʻonui malie i ka dosis (ma nā lōlō ma kahi o 2 mau pule) i 25 mg 2-3 mau manawa i ka lā. ʻO ka dosis kiʻekiʻe loa ʻo kēlā me kēia lā he 150 mg.

Ma ka ʻeha o ka haki ʻana o ka ventricle hema ma hope o ka loaʻa ʻana o kahi infococote myocardial i loko o nā mea maʻi ma kahi kūlana hauoli, ʻo ka hoʻohana ʻana o Cucksril-AKOS e hoʻomaka e like me 3 mau lā ma hope o kahi kīkē myocardial. ʻO ka dosis mua he 6.25 mg / lā, a laila hiki ke hoʻonui ʻia i ka lā o kēlā me kēia lā ka 37.5-75 mg i nā wai 2-3 (e pili ana i ka hoʻomanawanui o ka lāʻau). Inā pono, hoʻonui pinepine ʻia ka pākaukau i nā lā maʻamau i kēlā me kēia lā o 150 mg / lā. Me ka hoʻolālāʻana o ka hypotension arterial, pono paha kahi hōʻemi. ʻO nā hoʻāʻo ʻana e hoʻohana i ka hoʻohana ʻana i ka nui o kēlā me kēia lā ka nui o 150 mg e pono ke kau ʻia ma ka hoʻomanawanui e nā poʻe maʻi o Captopril-AKOS.

Me ka nephropathy maʻi maʻi, kahi laʻe o kēlā me kēia lā o 75-100 mg / lā i kuhikuhi ʻia no nā lā 2-3. Ma ka hihia o ka diabetes-hilinaʻi a me ka microalbuminuria (hoʻokuʻu i ka albumin 30-300 mg i kēlā me kēia lā), aia ka nui o 50 mg 2 mau manawa i ka lā. Me ka hoʻomaʻemaʻe piha piha o nā protein o ka ʻoi aku ma mua o 500 mg i kēlā me kēia lā, maikaʻi ka lāʻau lapaʻau ma ke ʻano o 25 mg 3 mau manawa i ka lā.

Me ka haʻahaʻa haʻahaʻa o ka hana renal impaired (creatinine clearance (CC) - ma kahi o 30 ml / min / 1.73 m), hiki ke kuhikuhi ʻia iā Cucksril-AKOS ma ke ʻano o ka 75-100 mg / lā. Me ka hapa nui o ka hopena o ka renal dysfunction (CC - a ʻoi aku i ka 30 ml / min / 1.73 m), pono ka nui o ka lāʻau mua ma mua o 12.5 mg / lā, a laila inā pono, e hoʻonui ka nui o ka nui o ka Cucksril-AKOS i nā wā lōʻihi. ka manawa, akā hoʻohana i kahi mea liʻiliʻi ma ka hihia o ka mālamaʻana i ka hypertension arterial, ka lāʻau o ka lā i kēlā me kēia lā. Inā pono, ua kau ʻia nā diuretics loop, a me nā mea diuretics o ka papa hyazide.

Loaʻa ka hopena

I nā poʻe maʻi ʻelemakule, ʻo ka hopena mua loa he 6.25 mg 2 mau manawa i ka lā.

Ke keu

Nā hōʻailona: kahi i hoʻemi ʻia o ke kahe o ke koko, i ʻole

hiolo, myocardial infarction, pilikia ulia cerebrovascular, hoʻopiʻi thromboembolic.

Hoʻomaʻamaʻa: kau i ka mea maʻi me ka hoʻohaʻahaʻa i lalo o nā ʻōpū, hoʻokaʻawale i ke hoʻihoʻi i ke koko (hoʻonui i ke kahe o ke koko, ʻo ka iv infusion o 0.9% sodium chloride solution), ʻo ka hōʻailona hōʻailona. ʻAʻole pono ia ka hoʻohana ʻana o ka hemodialysis, dialitis peritoneal.

Hoʻopili pū me nā lāʻau ʻē aʻe

ʻO nā lāʻau lapaʻau e hōʻemi i ka hana sympathetic i kuhikuhi i nā poʻe maʻi e hopu ana i ka captopril me ka makaʻala. Hāʻawi nā Beta-blockers i kahi hopena antihypertensive iki i ka wā i hoʻohui ʻia i ka capropril, akāʻo ka hopena o ka hopena ma mua o ka mea i manaʻoʻia.

Ua palupalu ka hopena antihypertensive e nā lāʻau anti-inflammatory non-steroidal (NSAID) (pani i ka Na + a hoʻemi i ka syntaglandin synthes), kūlike loa me ke kua ʻana o kahi haʻahaʻa o ka renin, a me ka estrogen (lohi Na +). ʻO ka hui pū me nā diuret thiazide, vasodilators (minoxidil), verapamil, beta-blockers, tricyclic antidepressants, ethanol hoʻonui i ka hopena hypotensive.

ʻO ka hoʻohana pū ʻana me ka diuretics potassium-sparing (no ka laʻana, triamteren, spironolactone, amiloride), mākaukau pākui, cyclosporine, haʻahaʻa paʻakai (e loaʻa paha iā K + a 60 mmol / l), nā mea hoʻohui o ka pākaha, nā paʻakai paʻakai (he nui nā koina o K +) e hoʻonui ai. ka hopena o ka hoʻomohala ʻana i ka hyperkalemia.

Hoʻowalewale i ke kaʻo ʻana o ka hoʻomākaukau lithium.

Me ka koho i ka captopril ke lawe ʻana i ka allopurinol a i ka procainamide paha, piʻi nui ka pilikia o ka hoʻomohala ʻana i ka maʻi Stevens-Johnson a me ka hana immunosuppressive. ʻO ka hoʻohana ʻana o ka captopril i nā maʻi e lawe ai i nā immunosuppressants (no ka laʻana, ka azathioprine a i ʻole ka cyclophosphamide) e hoʻonui i ka pilikia o ka hoʻomohala ʻana i nā maʻi hematological. ʻO ka hoʻohana like ʻana o ka ACE inhibitors a me insulin, a me ka lāʻau hypoglycemic waha hiki ke alakaʻi i ka holo ʻana o ka hypoglycemia. Hōʻalo ʻia ka nui o ka ulu ʻana i ka hypoglycemia i nā hebedoma mua o ka hui pū ʻana, me ia i nā mea maʻi me ka hana renal impaired. ʻO nā mea maʻi me ka maʻi maʻi e nānā pono i ka mālama glycemia, no ka mea i ka malama mua o ka maʻi me ka ACE inhibitor.

Nā hiʻohiʻona noi

Ma mua o ka hoʻomaka ʻana, a i ʻole maʻamau i ka wā o ka mālama ʻana me Creensril-AKOS, pono ka nānā ʻana o ka lawelawe ʻana. I nā maʻi me ka puʻuwai puʻuwai, ua hoʻohana ʻia lākou ma lalo o ka mākaʻi loea. E kūʻē i ke kāʻei o ka hoʻohana lōʻihi ʻana o Creensril-AKOS, ma kahi o 20% o nā maʻi e piʻi mau i ka urea a me ka serum creatinine ma mua o 20%, i hoʻohālikelike ʻia me ka waiwai maʻamau a mua paha. ʻOi aku ma mua o 5% o nā mea maʻi, ʻoi aku ka poʻe me ka nephropathy koʻikoʻi, e koi i ka hōʻemi o ka mālamaʻana ma muli o ka hoʻonui o ka neʻe ʻana o ka maka. I nā mea maʻi me ka haole hypertension me Creensril-AKOS, ʻike ʻia ka hypertension arterial i nānā wale ʻia i nā hihia loaʻa, hiki i ka hoʻomohala ʻana i ke ʻano me ka pohō o ka wai a me ka lilo o ka paʻakai (me ka laʻana, ma hope o ka maʻi kūleʻa me ka diuretics), i nā mea maʻi me ka puʻuwai naʻau paʻa ʻole a ma lalo o ka dialysis. . ^ E Ha yM. Hiki ke emi iki ka hopena o ke kahe o ke koko me ka hoʻopau ʻana i ka wā mua (4-7 mau lā) o kahi diuretic a i ka piʻi ʻana paha o ka paʻakai sodium klorida (ma kahi he hebedoma ma mua o ka hoʻomaka ʻana o ka lawelawe), a i ʻole ka hoʻokele ʻana o ka captopril i ka hoʻomaka ʻana o ka mālama ʻana i nā dosis liʻiliʻi (6.25- 12,5 mg / lā). I ka wā o ka lāʻau lapaʻau ma ke kumu maʻi outpatient, e hoʻomaopopo i ka mea maʻi e pili ana i ka hiki ʻana mai o nā hōʻailona o ka maʻi, e koi ana i ka hoʻokolokolo olakino e pili pono ana, nā hoʻomaʻamaʻa kaua a me ka lab. I nā mahina 3 ʻekolu. Mālama ʻo ia i kēlā me kēia mahina i ka nui o nā maʻi koko keʻokeʻo, a laila - 1 manawa i 3 mau mahina: i nā mea maʻi me nā maʻi autoimmune i nā malama 3 mua. - kēlā me kēia mau pule 2 mau pule, a laila - i kēlā me kēia 2 mahina. Inā hemo loa ia ka nui o nā leukocytes ma mua o 4000 / ll, hōʻike ʻia kahi hōʻike koko ākea, ma lalo o 1000 / μl, ua kāpae ʻia ka lāʻau lapaʻau. Inā hele mai ka ʻōmaʻomaʻi mua o ka maʻi lua e pili ana i ka mua o ka myeloid hypoplasia, pono e hana koke i kahi hōʻike hoʻoweliweli kikoʻī. Pono e hoʻokaʻawale i kahi kūʻokoʻa kūʻokoʻa o ka lāʻau a me kahi hoʻonui kūʻokoʻa kūʻokoʻa i ka ulu o ka hana kino. I kekahi mau hihia, kūʻē i ke ʻano o ke hoʻohana ʻana o nā inhibce ACE, ʻo ia hoʻi captopril, loaʻa i ka nui o ka neʻe o ka pāhana i loko o ka serum koko. Ka hoʻonui ʻia ʻana o ka hoʻoulu ʻana i ka hyperkalemia me ka hoʻohana ʻana i nā mea paʻa o ka ACE inhibitors i ka poʻe maʻi me ka maikaʻi ʻole a me ka diabetes mellitus, a me ka lawe ʻana aku i ka diuretics potassium-sparing, hoʻomākaukau o potassium a i nā lāʻau lapaʻau hou e hoʻoulu ai i ka manaʻo o ka pāhana i ka paʻakai i ke koko (no ka laʻana, heparin). ʻO ka hoʻohana like ʻana o ka diuretics potassium-sparing a me ka hoʻomākaukau ʻana i ka paʻakai e pono e pale ʻia. Ke lawe nei i ka hemodialysis i nā maʻi e loaʻa ana iā Creensril-AKOS, e hoʻohana pono ʻia ka hoʻohana ʻana o nā membaly dialysis kiʻekiʻe (e.g. AN69), i ia mau mea, e hoʻomāhuahua ʻia ka hopena o ka hoʻomohala ʻana i ka hopena anaphylactoid. I ka hihia o ka hoʻomohala ʻana o ka angioedema, ua hoʻopau ʻia ka lāʻau lapaʻau a nānā pono ʻia ke nānā ʻana i ka lāʻau lapaʻau a me ka hōʻailona hōʻailona. Ke lawe nei iā Creensril-AKOS, hiki ke nānā ʻia kahi hopena maikaʻi ʻole ke nānā ʻana i ka urine no ka acetone. ʻO ka hiki i ka lāʻau lapaʻau ka mea e hoʻopiʻi ai i ka hana a i ʻole nā mea hana no ke kino, ka launa pū me ka taba, ka waiʻona, ka meaʻai: i ka wā mālama, pono ia e hōʻalo i ke kaʻa ʻana i nā kaʻa a komo i nā hana hiki i ke ʻano he pōʻino e koi ai i ka hoʻonui nui ʻana o ka nānā a me ka wikiwiki o ka hopena psychomotor, no ka mea hiki ke maʻi, ʻoi aku ka hopena ma hope o ka lawe ʻana i ka ʻeha mua.

ʻO nā mea mālama palekana

ʻO nā mea mālama aku: hoʻohana i nā maʻi autoimmune koʻikoʻi (ʻoi aku ka systemic lupus erythematosus a i ʻole scleroderma), ka mālama ʻana i ka hematopoiesis kumulima o nā ʻōpū (ka pilikia o ka neutropenia a me agranulocytosis), ischemia cerebral, diabetes mellitus (nui aʻe ka piʻi ʻana o ka hyperkalemia), i nā maʻi ma ka hemodialysis sodium ka palena, ka hyperaldosteronism maʻamau, ka maʻi naʻau coronary, nā kūlana me ka hoʻoemi ʻia ʻana o ka nui o ke kahe koko (e pili ana i ke aniani, ka luaʻi), i ka ʻelemakule.

Me ka mālama aka, ua kau ʻia nā mea maʻi ma ka lāʻau paʻakai a i ʻole ka paʻakai (ka nui i hoʻonui ʻia i ka hoʻoulu ʻana i ka hypotension arterial) a me ka hyperkalemia.

I ke ʻano o ka uʻi aʻu e lawe ai?

ʻOi aku ka helu o ka nui o ke koko ma mua o 140/90 mm RT. ʻAniā. ʻO Creensril AKOS kahi lāʻau lapaʻau hana pōkole. Aia kona hopena ma kahi o 6 mau hola. No laila, ʻo ka manawa pinepine, ke kauka nei nā kauka i nā pilikia hypertensive, no ka hoʻohana mau ʻana ma ka hypertension i ʻōlelo ʻia i nā lāʻau lapaʻau lōʻihi.

Hiki iā ʻoe ke lawe i ka lāʻau lapaʻau i ka hoʻomaka ʻana o ka hypertension arterial, i ka nui o ka piʻi ʻana o ke kahe koko he mea ʻole a liʻiliʻi, a laila e kamaʻilio i kāu kauka. ʻAʻole ia i kuhikuhi ʻia i nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana o Creensril AKOS i ka mea e pono ai ka lilo. No laila, inā ʻo ka hopena o ka hana o ka lāʻau lapaʻau e kūpono i ka mea maʻi a me ke kauka hele ʻana, a laila hiki iā ʻoe ke waiho i kēia hoʻoponopono lapaʻau e like me ka hoʻohana mau ʻana.

Nā ʻōkuhi no ka hoʻohana

I mea e hōʻalo ai i nā hopena ʻaoʻao, hoʻomaka lākou e lawe i ka lāʻau lapaʻau me nā liʻiliʻi liʻiliʻi. Kuhi pinepine ʻia mai 6 a 12 mg 3 mau manawa i ka lā.
Hoʻoholo ʻia ka hopena ma hope o kekahi mau lā, pono e hōʻiliʻili ka lāʻau lapaʻau i loko o ke kino.
Inā ʻaʻole lawa nā dute mua i ka hopena, a laila hoʻonui ka nui o ka dosage i 25-50 mg 2 mau manawa i ka lā.
E like me ka mea e like ai i ka lā, hiki iā ʻoe ke lawe i ka 150 mg o ka lāʻau lapaʻau.
Me ka pilikia o hypertensive, ʻo ia hoʻi, ke hiki aku ka nui o ke koko i nā helu ma luna o 180/110 mm RT.Art., Lawe ia 25 mg o Cakopaa a kali i ke kaohi ʻana o ke kaomi no ka hapalua hola.
Inā ʻaʻole i hopena ka hopena, a laila hiki iā ʻoe ke hoʻomaʻi i ka lawe ʻana i kekahi lua.

Pehea ka lōʻihi o ka Cucksril AKOS e hōʻoluʻolu i ke kaomi?

Loaʻa kēia lāʻau lapaʻau i ke koko ma hope o nā minuke 15, hiki i ke koina o ka nui o nā mea i loko o 60-90 mau minuke, a laila e emi iki ana.

Hana a Cucksril no kahi mau hola 6, no laila ʻo 3 ka manawa o ka hoʻokele ʻana he 3 manawa.

Hoʻomaopopo nā maʻi hoʻomau i ka noi

Loaʻa nā loiloi e pili ana iā Katopril AKOS.

Loaʻa nā pono o ka lāʻau lapaʻau:

ka wikiwiki wikiwiki o ka hopena
me ka uku haʻahaʻa
maʻalahi nā papa pālani liʻiliʻi, maʻalahi ka moni ʻana,
hoopau i ke kāʻā, ke poʻo,
hiki ke hoʻohana i ka hale ma ke ʻano he kōkua mua,
hiki ke hoʻohana ʻia no ke piʻi ʻana o ka paʻakikī ma ke ʻano he nui.

Nā mea i ʻōlelo ʻia ʻole o ka pono o ka lāʻau lapaʻau.

ʻai hoʻōki ʻono
hopena pōkole
ʻaʻole kūpono no kēlā me kēia lā maʻamau, mau.
Loaʻa nā lāʻau lapaʻau hou aʻe no ka mālamaʻana i ka hypertension.

He aha ka hopena ma waena o Creensril a me Creensril AKOS?

ʻAʻohe ʻokoʻa a ke aʻo ʻana o Captril AKOS ma ke ʻano o ke aʻo ʻana o Captopril. No laila he aha ka hopena ma waena o Creensriln a me Captril AKOS? ʻO ka awiwi AKOS ka mea i hana ʻia ka lāʻau lapaʻau e ka hui kaiahi ʻo Kurgan o ka hoʻomākaukau a me nā huahana "Synthesis". Ua holo ʻo kēia hui mai ka makahiki 1958. Hoʻonui ka mea kanu i nā meaʻoi aku ma mua o 3% o nā huahana lapaʻau mai ka mākeke lāʻau Lūkini. Ke kūʻai aku nei nā huahana āpau i nā mana kūpono i nā pae āpau o ka hana.

Hoʻopili pū me nā lāʻau ʻē aʻe

Hoʻonui ka lāʻau huina diuretic i ka hana o ka captopril, ka hoʻonui ʻana i kona kao i loko o ke koko i kekahi mau manawa. Kuhi o ʻike ʻia nā hopena hypotensive i ka wā e lawe pū ana me kekahi NSAID, keu indomethacin.

Eia kekahi, ke emi nei ka hopena o ka hoʻohanaʻana i ka lāʻau inā inā ua hui pū ʻia me ka estrogens hana ʻenehana a ma ka manawa like, hoʻohana ʻo clonidine.

Hoʻohui maikaʻiʻia me nā paʻakai pākote a me ka paʻakai e hoʻokau ʻana i ka lohi ʻana o ka mea hope i loko o ke kino, a hoʻonāukiuki i ka hoʻāinu.

ʻO ka hoʻomohala ʻana o ka nausea, ka luaʻi a me ka nalowale o ka hoʻomaopopo ʻana ua ʻike ʻia me ka hoʻohana pinepine ʻana o ka captopril me nā hoʻomākaukau e pili ana i ke gula.

Ke pāpā ʻole ʻia nei e hui pū me nā lāʻau like ʻole:

Allopurinol a me procainamide - alakaʻi i ke kūkulu houʻana o ka maʻi Stevens-Jones, a hoʻonui pū i ka hopena o ka hoʻokumu a hoʻonui i nā neutropenia.
ʻO ka insulin - e pīhoihoi i ka manawa o ka hoʻomohala ʻana i ka hypoglycemia (ʻo ka nui o ka nui o ke kō o ke koko).
Hoʻokumu ʻo Cyclosporins - oliguria, e kū ana i ka pilikia ʻole.
Nā immunosuppressants e pili ana i ka Azathioprine - ke alakaʻi nei i ka hoʻokumuʻana o nā pathologies hematological (he pili koko i ka hoʻoliihua ʻana, hoʻemi ʻole ʻia nā loko o ke koko).

Inā pono ʻoe e hoʻohana iā Creensril a me nā lāʻau ʻē aʻe i ka manawa like, pono ʻoe e kamaʻilio mau i kāu kauka e pili ana i ka hiki ʻana o kahi hopena kūlohelohe kūpono.

Video: Kāleʻa Renal

I ka wā hāpai

ʻAʻole hoʻohana ʻia ʻo Cucksril ma ke ʻano ma loko o nā wahine hāpai, no ka mea hiki ke hoʻopilikia i kēia kūlana o ka maʻi hānai, e hoʻokau ana i nā pilikia naʻau congenital. Pono ʻoe e hōʻole i ka lawe i nā pills i ka wā o ka umauma, ka mea i komo i ka hana ikaika i loko o ka waiū a hiki i ke kumu o ka hōʻemi ʻana i ke kao i loko o ka pēpē.

Nā kuleana a me nā kūlana e waiho ai

ʻO 24 mau mahina mai ka lā o ka hana ʻana, e hōʻike nei i ke kāpena o Captoril Akos. Store ma kahi maloʻo maloʻo, i kahi wela o ka nui o ka 25 ° C.

ʻO ke kumukūʻai kumukūʻai ma nā lāʻau lapaʻau Lūkini no Captril Akos ʻaʻole iʻoi aku 25 mau rubles hona no 10 mau papa. I Ukraine, hiki ke kūʻai ʻia ka lāʻau lapaʻau ma ke kumukūʻai like - 25 hryvnia.

I waena o nā lāʻau lapaʻau e loaʻa ai ka hopena antihypertensive like, hiki iā mākou ke hoʻokaʻawale.

ʻO ka hapa nui o nā loiloi o ka poʻe maʻi e hoʻohana ana i ka Creensril Akos ma ke ʻano he lāʻau lapaʻau e hōʻike ana i kona pono kūpono. Hoʻomaopopo ka poʻe maʻi ʻaʻole i ka hana kiʻekiʻe wale nō, akā ʻo nā mea maikaʻi ʻē aʻe:

ke kumu kūʻai
aponoia e ka kino,
ʻaʻohe pilikia
ua hoʻomaopopo ʻia ka hopena ma hope o ke kau mua ʻana,
hiki ke hoʻohanaʻia e like me ka mahele o ka hopena paʻakikī.

ʻO nā hihia kūʻokoʻa wale nō he intolerance pilikino i captopril i hōʻike ʻia ma ke ʻano o kahi maʻi alakania (urticaria).

Hoʻohālikelike

I keia ala Hoʻohui ke Creensril Akos i nā hana kiʻekiʻe a me nā kumukūʻai kūpono, ke ʻae nei iā ʻoe e kūʻai manuahi i ka lāʻau i loko o kekahi lāʻau lapaʻau. Kuhi ʻia i nā ʻōlelo a pau a nā kauka a ke kauka, ʻaʻole ka hopena o ka lāʻau lapaʻau i ka hopena ʻino. I ka hoʻomakaʻana o nā hopena alakaline, ma mua o ka hoʻomaka o ka papa o ka hoʻomaʻamaʻa, kahi hōʻike hōʻike hōʻike no ka hoʻomaka ʻana o nā hopena ʻino.

Nā ʻano, nā inoa, ke ʻano a me ke ʻano o ka hoʻokuʻu ʻana

Loaʻa kēia Captril i loko o kēia mau ʻano like ʻole:

Kanakaole
Cilolopa Vero
Paikiale Hexal,
Paikialia Sandoz,
Kanehole-AKOS,
Creagelia Acre
Kanakaole-Ros,
Paikea Sar,
CIOLIKA-STI,
Kanikaole-UBF,
Kanikaole-Ferein,
Kanikaole-FPO,
Cadaika Stada,
Huikau ʻO Egis.

ʻO kēia mau ʻano o ka lāʻau lapaʻau ka ʻokoʻa i kēlā me kēia ma o ka hiki ʻana i kahi huaʻōlelo hou i ka inoa, e hōʻike ana i ka puʻupuʻu a i ʻike kaulana paha i ka mea hana o kekahi ʻano lāʻau. A i ʻole, he like ʻole nā ʻano o Cewareril mai kekahi i kekahi, ʻoiai ua hana ʻia ma nā ʻano like like ʻole, ua like nō ko ia ʻano ʻano like ʻole, a me nā mea hou aku, he pinepine nā mea ikaika i nā hua Calaopala like, like, no ka mea ua kūʻai ʻia ia mai nā mea nui Kina a ʻo India.

ʻO nā ʻokoʻa i nā inoa inoa o nā ʻano Cewareril ma muli o ka pono o kēlā me kēia hui lapaʻau e hoʻopaʻa ai i ka lāʻau lapaʻau a lākou e hana ai ma lalo o ka inoa inoa, kahiʻokoʻa i nā poʻe ʻē aʻe. A iāiai i ka wā ma mua, i ka manawa Soviet, ua hana kēia mau lāʻau lapaʻau like me ka Captrilka like me ka ʻenehana like ʻole, ua hoʻohui wale lākou i hoʻokahi huaʻōlelo i kahi inoa kaulana, ʻo ia kahi hoʻopukapuka o ka inoa o ka hui, a, no laila, loaʻa mai kahi inoa kūʻokoʻa mai kahi mana o ke kānāwai. ʻokoʻa mai nā mea ʻē aʻe.

No laila, ʻaʻohe mau hopena ʻokoʻa ma waena o nā ʻano o ka lāʻau lapaʻau, a no laila, e like me ke ʻano he kānāwai, ua hui pū ʻia ma lalo o hoʻokahi inoa inoa Cucksril. Eia hou ma ke kikokikona o ka ʻatikala mākou e hoʻohana ai i kahi inoa - Captopril - e hōʻike i nā ʻano like ʻole.

Loaʻa nā ʻano like ʻole o Captopril i hoʻokahi puka pākahi - ʻo kēia nā papa waha. ʻOi ke ʻano ikaika papa i nā mea waiwai pio, ka inoa o ia mea, ka mea, ua haawi i ka inoa o ia la- hu.

Loaʻa nā ʻano kamana Cucksril i nā ʻano like ʻole, e like me 6.25 mg, 12.5 mg, 25 mg, 50 mg a me 100 mg no kēlā me kēia papa pā. ʻO ia ʻano laulā e loaʻa ai iā ʻoe ke koho i ke koho maikaʻi loa no ka hoʻohana ʻana.

Ma nā mea kōkua Aia paha i nā ʻano kīnā ʻo Cobiaril i nā ʻano mea like ʻole, no ka mea hiki i kēlā me kēiaʻoihana ke hoʻololi i kā lākou ʻano, ke hoʻāʻo nei e hoʻokō i nā ʻōmaʻomaʻo o ka hana pono. No laila, i mea e wehewehe pono ai i ka hoʻohui ʻana o nā mea kōkua o kēlā me kēia ʻano ʻano o ka lāʻau, pono e noʻonoʻo pono i ka pepa i hoʻopili ʻia me nā ʻōkuhi.

ʻO ka ʻāpana no ka C ʻanawela ma ka ʻōlelo Latin i kākau ʻia penei:
Rp: ʻLelo. Creensrili 25 mg No. 50
D.S. Lawe iā 1/2 - 2 papa 3 mau manawa i ka lā.

ʻO ka papa mua o ka papa inoa ma hope o ka pōkole "Rp" e hōʻike i ka puka dosage (ma kēia hihia Tab. - nā papa), ka inoa o ka lāʻau lapaʻau (ma kēia hihia, Captoprili) a me kāna ona dosage (25 mg). Ma hope o ka "Ikona" ikona, hōʻike ʻia ka helu o nā papa e pono ai ke hoʻokuʻu i ka mea kūʻai aku i ka mea kūʻai aku. Ma ka lālani lua o ka paʻi ma hope o ka pōkole "D.S." hoʻolako ʻia ka ʻike no ka mea maʻi i loaʻa nā ʻōlelo pili i ka pehea e lawe ai i ka lāʻau lapaʻau.

He aha ka mea e kōkua ai i ka captopril (therapeutic effect)

Kanakaole hoʻemi kahe koko a hoʻoemi i ka ukana ma ka puʻuwai. Wahi a ia, hoʻohana ʻia ka lāʻau i ka mālama ʻana i ka hypertension arterial, maʻi ʻeha (hōʻeha ka naʻau, myocardial infarction, myocardial dystrophy), me ka maʻi nephropathy maʻi.

ʻO ka hopena o Captopril e pani i ka hana o ka enzyme, kahi e hōʻoia ai i ka hoʻololi ʻana o ka angiotensin I i ka angiotensin II, no laila, aia ka lāʻau i ka pūʻulu o A inhibitors (angiotensin-hoʻohuli i ka enzyme). Ma muli o ka hana o ka lāʻau lapaʻau, ʻaʻole i hoʻokumu ʻia ka angiotensin II i loko o ke kino - kahi ʻano i loaʻa ka ikaika vasoconstrictor a, a laila, e hoʻonui ai i ke koko. Ke hana ʻole ʻia ka angiotensin II, hoʻomau ʻia nā kīʻaha koko a, no laila, maʻa mau ke ʻano o ke koko a ʻaʻole i hāpai ʻia. Mahalo i ka hopena C afaiopakiki, i ka manawa e lawe pinepine ʻia, kahe ka nui o ke koko a mālama i loko o nā palena ʻae ʻia a ʻae ʻia. ʻO ka palena kiʻekiʻe loa i ke kaomi ka mea 1 - 1.5 mau hola ma hope o ka lawe ʻana iā Cucksril. Akā no ka hiki ke loaʻa i kahi kaomi mau i ka neʻe ʻana o ka maʻi, pono e lawe ʻia i ka lāʻau no nā liʻiliʻi he mau hebedoma (4-6).

Eia kekahi lāʻau lapaʻau hōʻemi i ka kaumaha ma ka puʻuwai, ka hoʻonui ʻana o ka lumen o nā moku, ma muli o ka pono o ka ʻōpū o ka puʻuwai e pono ai i ka hoʻoikaika ʻana e hoʻolei i ke koko i loko o ka aorta a me ka pulmonary artery. No laila, hoʻonui ka captopril i ka hoʻomanawanui o ke olakino a me ke kaumaha o ka poʻe i pilikia i ka hōʻeha naʻau a i loaʻa i ka infococept myocardial. ʻO kahi waiwai nui o Captopril ka nele o kahi hopena o ka waiwai o ke koko i ka wā e hoʻohana ʻia ai ka mālama ʻana i ka hana o ka puʻuwai.

Eia pū kekahi hoʻomaikaʻi i ke kahe koko a me ka hāʻawi ʻana i ke koko i ka puʻuwaima muli o kahi o ka lāʻau e hoʻohana ai i ka mālama paʻakikī i ka loaʻa ʻole o ka puʻuwai kani a me nā nephropathy maʻi.

Ua kūpono kūpono ʻo Creensril no ka hoʻopili ʻana i nā hoʻohui like me nā ʻano ʻē aʻe nā lāʻau antihypertensive. ^ E Ha yM. Eia kekahi, ʻaʻole ka mālama o Captril i ka wai i loko o ke kino, ka mea nāna e hoʻokaʻawale iā ia mai nā mea lāʻau antihypertensive e loaʻa kahi like. ʻO ia ke kumu, ʻoiai e lawe ana iā Cucksril, ʻaʻole pono ʻoe e hoʻohana i ka diuretics i mea e hoʻopau aku ai i ka edema e hōʻea ʻia e ka lāʻau antihypertensive.

Nā kiko waiwai a me nā hewa

Pono e lawe ʻia ʻo Cucksril i hoʻokahi hola ma mua o ka ʻaina, ʻaina i ka papa ʻaina piha ʻole, me ka ʻaihue ʻole, ʻōmole a ʻāwī paha i kēlā me kēia ʻano ʻē aʻe, akā me ka wai nui (ma ka liʻiliʻi o ka hapa aniani)

Koho ʻia ka nui o nā palapala no ka captopril, e hoʻomaka me ka liʻiliʻi, a me ke neʻe ʻana i ka hopena. Ma hope o ka lawe ʻana i ka hapa mua o 6.25 mg a i ka 12.5 mg, pono e ana ke kahe o ke koko i kēlā me kēia hapalua hola no ʻekolu mau hola e hoʻoholo ai i ka hopena a me ka hōʻeha o ka lāʻau lapaʻau i kekahi kanaka. I ka wā e hiki mai ana, me ka hoʻonui ʻia o nā ʻōpū, pono e ana ʻia ka neʻe ʻana i ka manawa hoʻokahi ma hope o ka lawe ʻana i ka paila.

Pono e hoʻomanaʻo ʻia o ka nui o ka lā i ʻae ʻia i ka lā o captopril i 300 mg. ʻO ka lawe ʻana i ka lāʻau lapaʻau i ka nui o ka 300 mg i kēlā me kēia lā, ʻaʻole ia i ke kahe nui ʻana o ka hoʻokahe koko, akā hoʻonāukiuki i ka ulu ʻana o ka hopena o ka hopena. No laila, lawe i ka Captril ma kahi he nui o 300 mg i kēlā me kēia lā he hiki ʻole a kūpono ʻole.

Captril no ka paipai ʻana (me ka uluʻana o ka hypertension) hoʻomaka i ka 25 mg hoʻokahi i ka lā a i ʻole 12.5 mg 2 mau manawa i ka lā. Inā ma hope o 2 mau hemo e hoʻokahe ai ke kahe koko i nā waiwai i manaʻo ʻia, a laila e hoʻonui ʻia ka nui a loaʻa iā 25-50 mg 2 mau manawa i ka lā. Inā lawe ʻoe iā Captopril ma kēia ʻano nui, ʻaʻole i emi ke kaohi i nā waiwai i ʻāpono ʻia, a laila e pono ʻoe e hoʻohui i ka Hydrochlorothiazide 25 mg i kēlā me kēia lā a i ʻole beta-blockers.

Me ka haʻahaʻa a me ka hypertension maʻalahi paha, he nui ka nui o ka captopril maʻa 25 mg 2 mau manawa i kahi lā. Ma ka hypertension koʻikoʻi, ua hoʻololi ʻia ka nui o ka Cewareril i 50-100 mg 2 mau manawa i ka lā, e pākuʻi ʻia i kēlā me kēia pule. ʻO ia, i nā pule mua ʻelua, e lawe ke kanaka i ka 12.5 mg 2 mau manawa i ka lā, a laila ma hope o nā hebedoma ʻelua e - 25 mg 2 mau manawa i ka lā, a pēlā aku.

Me ke koko o ke koko nui ma muli o nā maʻi ʻeha, e lawe ʻia ʻo Captril ma 6.25 - 12.5 mg 3 mau manawa i ka lā. Inā ma hope o 1 - 2 pule ka hoʻemi ʻana o ke kaomi i nā waiwai i ʻoluʻolu, a laila hoʻonui ʻia ka nui a lawe ʻia 25 mg 3-4 mau manawa i ka lā.

I loko o nā pūpū puʻuwai hema Hoʻomaka ke kamepiula iā ʻoe e lawe i 6.25 - 12.5 mg 3 mau manawa i ka lā. Ma hope oʻelua pule, e pāpālua ke kao, lawe ʻia ka nui o 25 mg 3 mau manawa i ka lā, a lawe ʻia ka lāʻau lapaʻau no ka manawa lōʻihi. I ka puʻuwai puʻuwai, e hoʻohana ʻia ʻo Captopril me ka hoʻohui me diuretics a i ʻole glycosides cardiac.
ʻOi hou e pili ana i ka puʻuwai naʻau

Me ka infarction myocardial Hiki ke kiʻi ʻia ka Captril i ke kolu o ka lā ma hope o ka hopena o ka manawa paʻa. I nā lā mua 3-4, pono ia e lawe i ka 6.25 mg 2 mau manawa i ka lā, a laila e hoʻonui ʻia ka lāʻau lapaʻau ma 12.5 mg 2 mau manawa i ka lā a inu i hoʻokahi pule. Ma hope o kēia, me ka hoʻokuʻu maikaʻi o ka lāʻau lapaʻau, ua pono e hoʻololi i ka 12.5 mg ʻekolu mau manawa i ka lā no 2 a 3 wiki. Ma hope o kēia manawa o ka manawa, ma lalo o ke kūlana o ka hoʻokaʻawaleʻana o ka lāʻau lapaʻau, huli lākou i 25 mg 3 mau manawa i ka lā me ka mana o ka maʻamau. Ma kēia ʻaiau, lawe ʻia ka captopril no ka manawa lōʻihi. Inā ʻaʻole lawa ka nui o ka 25 mg 3 mau manawa i ka lā, a laila e ʻae ʻia e hoʻonui iā ia i ka nui - 50 mg 3 mau manawa i ka lā.
ʻOi aku e pili ana i kahi kani Myocardial

Me ka nephropathy maʻi maʻi Hoʻonohonoho ʻia ka Captril e lawe 25 mg 3 mau manawa i ka lā a 50 50 mau manawa i ka lā. Me ka microalbuminuria (albumin i loko o ka ihi) ʻoi aku ma mua o 30 mg i kēlā me kēia lā, pono ʻia ka lāʻau lapaʻau ma mua o 50 mg 2 mau manawa i ka lā, a me ka proteinuria (protein i loko o ka urine) ma mua o 500 mg i kēlā me kēia lā e inu ai ʻo Cakéril 25 mg 3 mau manawa i ka lā. Ke piʻi nei ka nui i nā mea i hōʻike ʻia, e hoʻomaka ana me ka liʻiliʻi, a me ka hoʻonui ʻana i ʻelua i ʻelua mau pule ʻelua. Hiki i ka ʻokoʻa ʻokoʻa o ka captopril no ka nephropathy, no ka mea ua hoʻoholo ʻia e ka nui o ka hopena o ka renal. Hōʻike ʻia nā palena liʻiliʻi ma kahi e hoʻomaka ai e lawe iā Captopril no nephropathy maʻi, pili i ka hana o nā kuhi ke hōʻike i ka papaʻaina.

*ʻO ka hōʻaiʻe piha, ml / min (i hoʻoholo ʻia e ka hōʻike ʻo Reberg)*	*ʻO ka lā helu mua o kēlā me kēia lā o Captopril, mg*	*ʻO ka nui loa o kēlā me kēia lā o captopril, mg*
40 a i luna	25 - 50 mg	150 mg
21 – 40	25 mg	100 mg
10 – 20	12.5 mg	75 mg
Ka emi loa ma 10	6.25 mg	37.5 mg

Kahi ʻia nā maʻi i kuhi ʻia i kēlā me kēia lā i 2 a hiki i 3 mau pona i ka lā. ʻO nā kānaka'ōmaʻomaʻo (ma mua o 65), ka mea e pili ana i ka hana renal, e hoʻomaka i ka lawe ʻana i ka lāʻau lapaʻau ma 6.25 mg 2 mau manawa i ka lā, a ma hope o ʻelua pule, inā pono, e hoʻonui i ka dosage i ka 12.5 mg 2 a i 3 mau manawa i ka lā.

Inā ʻeha kahi kanaka i kekahi maʻi o ka pūpū (ʻaʻole maʻi nephropathy diabetes), a ua hoʻoholo ʻia ka dosage o Captopril ma ke ʻano o ka creatinine clearance a he ʻano like me ka nephropathy maʻi.

Hoʻohana i ka wā hāpai a me ka umauma

Contraindicated ʻo Creensril no ka hoʻohana ʻana ma ka wā hāpai a pau, no ka mea, ua hōʻike ʻia nā hoʻokolohua hoʻokolohua ma nā holoholona i kona hopena o ka maʻi hānai ma ka kuʻi. ʻO ka lawe ʻana i ka lāʻau lapaʻau mai ka 13th a 40 mau pule o ka hāpai ʻana i hiki ke alakaʻi i ka make a me nā hana maikaʻi ʻole.

Inā lawe ka wahine i ka captopril, a laila e kāpae koke ia, ma ka manawa e ʻike ai i ka hoʻomaka ʻana o ka hāpai.

Ua komo ʻo Cucksril i loko o ka waiū, no laila inā pono, pono ʻoe e hōʻole i ka umauma-hānai i kahi pēpē a hoʻoneʻe i ia i nā ʻano hoʻonaninani.

Nā ʻōlelo kikoʻī

No nā keiki ma lalo o ka 18 mau makahiki o ka hoʻohana ʻana, ke hoʻohana wale ʻia ʻo Captril ma ke ʻano he pilikia, e helu ana i ka nui o ka nui ma muli o ke kaumaha o ke kino, e pili ana i ka pāʻana o 1 - 2 mg no 1 kg o ka paona i kēlā me kēia lā.

Inā nalowale ʻoe i ka paila hope aʻe, a laila ma ka manawa ʻē aʻe e pono ai ʻoe e lawe i ka ʻai maʻamau, ʻaʻole i pālua.

Ma mua o ka hoʻomaka ʻana i ka captopril, pono ia e hoʻihoʻi i ka nui o ka wai a me ka hoʻopili ʻana o nā electrolytes i loko o ke koko inā ʻike ʻia lākou i ke ala ʻole ma muli o ka diuretics, nā maʻi hoʻokūkū, hoʻopuka, a pēlā aku.

I ka manawa holoʻokoʻa o ka hoʻohana ʻana o Captopril, pono ia e kāohi i ka hana o nā keiki maʻi. Ma 20% o nā poʻe, ke lawe nei i ka lāʻau, hiki i ka proteinuria (pūmū i loko o ka urine), kahi mea pono ma kona wahi ponoʻī i loko o 4 a 6 wiki ʻaʻole mālama ʻia. Eia naʻe, inā he ʻoi aku ka ʻike o ka protein ma loko o ka urine ma mua o 1000 mg i ka lā (1 g / lā), a laila pono e oki ʻia ka lāʻau lapaʻau.

Pono e hoʻohana ʻia ʻo Cucksril ma ka akahele a ma lalo o ka mākaʻi lapaʻau kokoke inā loaʻa i kēia mau ʻano a i ʻole nā maʻi e pili ana:

ʻŌnaehana ʻōnaehana vasculitis,
E hoʻohālikelike i nā maʻi o ka kiko pilna,
ʻO ka stenosis hāmeʻa renalela,
ʻO ka loaʻa o nā immunosuppressants (Azathioprine, Cyclophosphamide, etc.), Allopurinol, Procainamide,
Ke mālama nei i ka hoʻokolohua desensitizing (no ka laʻana, bee venom, SIT, etc.).

E hana i kahi hōʻike koko ākea i kēlā me kēia pule ʻelua ma mua o ʻekolu mau mahina o ka lapaʻau. Ma hope aku, e hana ʻia ana kahi hōʻike koko ma kēlā me kēia manawa, a hiki i ka hopena o Captopril. Inā emi ka huina o ka leukocytes i emi mai ka 1 G / l, a laila hiki ke oki i ka lāʻau. ʻO ka maʻamau, ua hoʻihoʻi ʻia ka helu maʻamau o nā kaila koko keʻokeʻo i loko o nā hebedoma 2 ma hope o ka hoʻokuʻu ʻana o ka lāʻau. Eia kekahi, pono e hoʻoholo i ke koʻo o ka protein i loko o ka urine, me ka creatinine, urea, ka nui o ka protein a me ka pāima i loko o ke koko i ka manawa holoʻokoʻa o ka lawe ʻana iā Cakéril ma kēlā me kēia mahina. Inā ʻoi aku ka kiʻekiʻe o ka protein ma ka pāʻai ma mua o 1000 mg i hoʻokahi (1 g / lā), a laila pono e oki ʻia ka lāʻau lapaʻau. Inā piʻi pinepine ka ʻike o ka urea a i hana paha ma loko o ke koko, a laila e hoʻemi ʻia ka dosage o ka lāʻau lapaʻau a i ʻole e pau.

No ka hōʻemi i ka hopena o ka hōʻemi i ke kahe o ka neʻe i ka hoʻomaka ʻana o ka captopril, pono ia e hoʻopau i ka diuretics a hōʻemi paha i kā lākou dosage e 2 a 3 mau manawa 4 a 7 mau lā ma mua o ka paila mua. Inā, ma hope o ka lawe ʻana iā Creensril, e iho lohi ana ke koko, ʻo ia hoʻi ke ʻano o ka hypotension, a laila pono ʻoe e moe ma kou kua ma ka ʻaoʻao kuʻi a hoʻonui i kou mau wāwae i luna o ko lākou poʻo aʻe. I kēia kūlana, pono e moe no 30-60 mau minuke. Inā paʻakikī ka hypotension, a laila e hoʻopau koke iā ia, hiki iā ʻoe ke komo i ka hopena paʻakai sterile maʻamau intravenously.

No ka mea e hoʻonāukiuki pinepine nā dosis mua o Creensril i ka hypotension, ʻoi ʻia ke koho i ke ʻano o ka lāʻau lapaʻau a hoʻomaka i kona hoʻohana ʻana i ka hale mālama ma lalo o ka mālama mau ʻana o nā limahana olakino.

E pale aku i ke ʻano o ke hoʻohana ʻana o Cucksril, ʻo kekahi mau mea hoʻokipa, me ka niho (no ka laʻana, ʻoi ʻia ka niho), e hana me ka akahele. ʻO ka hoʻohana ʻana o ka anesthesia aoao i ka wā e lawe ai iā Cebookril hiki ke hoʻonāukiuki i ka hōʻemi o ke kaomi, no laila, pono e hōʻike ʻia ka mea hoʻomaʻamaʻa e lawe ana kekahi i kēia lāʻau lapaʻau.

Me ka hoʻomohala ʻana o ka jaundice, pono ʻoe e ho'ōki i ka lawe ʻana iā Cucksril.

No ka manawa holoʻokoʻa o ka hoʻohana ʻana i ka lāʻau, pono ia e haʻalele loa i ka hoʻohana ʻana i nā mea inu ʻona.

Ma ke kiʻi o ka lawe ʻana i ka lāʻau lapaʻau, ʻike ʻia kahi hoʻokolokolo maikaʻi ʻole no ka acetone i loko o ka pāʻai, pono e noʻonoʻo ʻia e ke kauka a me ka mea maʻi ʻo ia iho.

Pono e hoʻomanaʻo ʻia inā inā i ʻike ʻia nā hōʻailona ma hope o ke ala ʻana o Captopril, pono koke ʻoe e kamaʻilio i ke kauka:

ʻO nā maʻi ʻeha, e pili pū ana i ke anu, ka wai kaila, a,.
Ka hoʻonui ʻana o ka wai momona (no ka laʻana, me ka hoʻopiʻi ʻana, ke nānā ʻana, ka momona nui, a me kekahi mea).

ʻO ka hoʻohana ʻana o ka captopril i kekahi manawa e hoʻoulu ai i ka hyperkalemia (hoʻokiʻekiʻe i ka nui o ka pāhana i loko o ke koko). Loaʻa iā lākou kahi kiʻekiʻe o ka hyperkalemia i ka poʻe e loaʻa ana i ka maʻi papaleka ʻole a i ʻole ka maʻi mellitus, a me nā mea e pili ana i ka ʻai paʻakai. No laila, e pili ana i ke kūmole o ka hoʻohana ʻana o Cebookril, pono e hōʻole i ka lawe ʻana i ka diuretics pākia-waʻa (Veroshpiron, Spironolactone, etc.), hoʻomākaukau ʻai kalaka (Asparkam, Panangin, etc.) a me heparin.

E kūʻē i ke kūmole o ka hoʻohana ʻana iā Captopril, hiki i ke kanaka ke hoʻomau i ka ʻeha ma ke kino, ʻo ka mea maʻamau i loko o ka 4 mau pule o ka hoʻōla ʻana a me ka nalo ʻana me ka hoʻohaʻahaʻa ʻana i ka dosage a i ʻole ka hoʻokele hou ʻana o antihistamines (e.g. Parlazin, Suprastin, Fenistil, Claritin, Erius, Telfast, etc.). Eia nō naʻe, ʻo ka lawe ʻana iā Cucksril, he uukū mau loa ʻole (me ka haʻalele o ka huʻu), ʻehia ka haunaele a me ka hoʻolilo nui ʻana, akā, pau mau hopena āpau i nalo 2 a 3 mau mahina ma hope o ke kūleʻa ʻana o ka lāʻau.

Hoʻopili pū me nā lāʻau ʻē aʻe

Hoʻoulu ka Crilril i ka hopena o nā lāʻau hypoglycemic (Metformin, Glibenclamide, Gliclazide, Miglitol, Sulfonylurea, etc.), no laila, i ka wā e hui pū ʻia, pono e kiaʻi mau ʻia ke kaila o ke koko. Eia kekahi, hoʻonui ʻo Captopril i ka hopena o nā lāʻau no ka anesthesia, painkillers a me ka waiʻona.

Hāpai ka diuretics a me nā vasodilators, antidepressants, antipsychotics, Minoxidil a me Baclofen e hoʻonui nui i ka hopena hypotensive o Captopril, ma muli o ia, i ka wā e hoʻohana pū 'ia, hiki ke piʻi ikaika ʻia ke koko. Nā pākēnē Beta-blockers, ganglion blockers, pergolide a me interleukin-3 e hoʻomaikaʻi hou i ka hopena hypotensive o Captopril, me ka hoʻoluhi ʻole ʻana i kahi kao o ke kaomi.

Ke hoʻohana nei i ka captopril i hui pū me ka nitrates (nitroglycerin, sodium nitroprusside, etc.), he mea pono e hōʻemi i ka dosage o ka hopena.

Nā NSAIDs (Indomethacin, Aspirin, Ibuprofen, Nimesulide, Nise, Movalis, Ketanov, etc.), aluminium hydroxide, magnesium hydroxide, carbonate hydroxide, orlistat a clonidine hōʻemi i ka nui o Cavitaril.

Hoʻonui ʻo Cakrilril i ka paʻa o ka lithium a me ka digoxin i ke koko. Wahi a ia, ʻo ka lawe ʻana i ka hoʻomākaukau o lithium me Creensril hiki ke hoʻonāukiuki i ka hoʻomohala ʻana o nā hōʻailona o ka hoʻomohala lithium.

ʻO ka hoʻohana pū ʻana o ka captopril me ka immunosuppressants (Azathioprine, Cyclophosphamide, etc.), Allopurinol, a i ʻole Procainamide e hoʻonui i ka hopena o ka neutropenia (e hoʻohaʻahaʻa ana i nā pae koko koko ma lalo o ka maʻamau) a me kahi maʻi Stevens-Johnson.

ʻO ka hoʻohana ʻana o ka captopril e pili ana i ka hoʻomaka ʻana o ka hoʻomanawanui desensitizing therapy, a me ka hui pū me ka estramustine a me nā gliptins (linagliptin, sitagliptin, etc.) i hoʻonui i ka hopena o ka hopena anaphylactic.

ʻO ka hoʻohana ʻana o ka captopril me ka hoʻomākaukau ʻana i ke gula (Aurothiomolate a me nā mea ʻē aʻe) e hoʻoulu ai i ka ʻulaʻula o ke kino, ka ninihia, ka luaʻi a me ka hoʻokahe o ke koko.

Nā ʻaoʻao ʻaoʻao o ka uila

Hiki i nā papa kīmona ke hōʻeha i nā hopena ʻaoʻao aʻe mai nā kino a me nā ʻōnaehana:

1.Pūnaehana ʻōiwi a me nā ʻōpū sensory:

Kaumaha,
ʻʻAla
Nā Aliʻi
Kūpono o nā ʻōnaehana o ke kikowaena,
ʻEhaʻeha
Hala
Hōʻikeʻike
Ataxia (pūhui hoʻonā o nā neʻe),
Nā uhi momona
Paresthesia (ka ʻike ʻana o ka paʻila, tingling, "goosebumps" i nā wāwae)
ʻIke ʻole ʻia a ʻohu paha,
ʻO ka maʻi ʻono
Hōʻailona.

2.Pūnaehana Cardiovascular a me ke koko:

Hypotension (hoʻohaʻahaʻa i ke koko haʻahaʻa)
ʻO Orthostatic hypotension (kahi kī i ka pihi i ka neʻe ʻana i ka wā e neʻe ana mai ka noho a noho ana paha a kau i kahi kūlana kūpaʻa)
Ana Angina pectoris,
Myocardial infarction
Naona Aria
Kauʻuwai
Acute cerebrovascular ulia,
ʻO ka edema Peripheral,
Lymphadenopathy
Anemia
ʻEha ʻeha
ʻO ka Hōʻailona o Raynaud
ʻO nā ʻalā
Pallor o ka ʻili
Pōhoihoi Cardiogenic,
Hopu thromboembolism,
ʻO Neutropenia (hoʻemi i ka nui o nā neutrophils i ke koko),
ʻO Agranulocytosis (nalo piha i nā basophils, eosinophils a me neutrophils mai ke koko),
ʻO ka thrombocytopenia (hoʻemi i ka helu o ka platelet ma lalo o ka maʻamau),
Eosinophilia (hoʻonui i ka nui o nā eosinophils ma mua o ka maʻamau).

3.Pūnaehana lawelawe:

Kumauaka,
Hoʻopili iki i ka hanu
ʻO ka paōkula interstitial,
Bronchitis
Rhinitis
Uʻi huehue ʻole hua (me ka luʻu sputum).

4.ʻLelo Gastrointestinal:

Anorexia
ʻO ka maʻi ʻono
Stomatitis
ʻEha ma luna o ka huakanu o ka waha a me ka ʻōpū,
ʻO Xerostomia (waha maloʻo ma muli o ka hiki ʻana o ka salivation)
Hōʻaha ʻia (ʻōlaʻi o ka alelo),
Gingival hyperplasia,
Pau ka make,
Kahula
Lohea
ʻO Dyspepsia (flatulence, bloating, abdominal pain, ʻeha i ke kaumaha i loko o ka ʻōpū ma hope o ka ʻai ʻana, a me kekahi ʻano).
Kaaudeana
Nā maʻi maʻi
ʻO ka pancreatitis
Cholestasis
ʻO ka maʻi hepatitis Cholestatic
ʻO ka corrhosis Hepatocellular.

5.ʻAi ʻia me ka ʻōnaehana a me ka hoʻopili:

Hoʻopau i nā hana renal hana, a hiki i ka hoʻomaʻamaʻa ʻole o ka renal;
Polyuria (hoʻonui i ka pae i ka urine ma mua o ka maʻamau),
Oliguria (hoʻemi i ka hopena o ka urine ma lalo o ka maʻamau),
ʻO Proteinuria (protein i loko o ka urine),
Hoʻonui ʻia ka nui a me ka nui o nā urlines
Kuhiule.

6.ʻO ka ʻili a me nā pulu palu:

He ʻulaʻulaʻula
ʻO kahi pūʻulu ma ke kino
ʻO ka ʻili
Ex deroliitis exfoliative,
Toxic epidermal necrolysis,
Pemphigus
Emaxolelman,
Tinea versicolor
Alopecia (baldness),
Photodermatitis.

7.Nā maʻi kūwaha:

ʻO Kēlā Kukui Stevens-Johnson
ʻĀpio,
ʻO ka makeʻe o Quincke,
Anaphylactic pīhoihoi.

8.ʻO kekahi:

Kūʻai
Kūleʻa
Sepsis (huikala koko),
Hoʻokomo ʻia ke kūpikipiki
Myalgia (ʻehaʻeha),
Hyperkalemia (hoʻonui i ka paʻakai i ke koko ma mua o ka maʻamau),
Hyponatremia (kahi hōʻemi i ka pae o ka sodium i ke koko ma lalo o ka maʻamau),
ʻO ka hypoglycemia (hoʻokahe koko haʻahaʻa) i nā kānaka e lawe i ka insulin a i nā lāʻau lapaʻau hypoglycemic ʻē aʻe,
ʻO Gynecomastia
Maʻi maʻi
Hoʻonui ka hana o nā enzyme o ka ate (AsAT, AlAT, phosphatase alkaline, etc.),
I ka hoʻonui ʻia o ka urea, ka mea hana a me ka bilirubin i loko o ke koko, a me ESR hoʻi,
Hōʻemi ka hemoglobin a me ka hematocrit
Acidosis
ʻO ka hoʻāʻo maikaʻi maikaʻi ʻana no ka ʻike ʻana i kahi antigen nukle.

Kāuhea - Analogs

I kēia manawa, i loko o ka mākeke kūʻai kūloko home, ʻelua mau ʻano o ka hui pū ʻana o ka Cewareril - he mau like a me nā mea ʻakomi. Hoʻokomo pū ʻia nā huaʻōlelo e pili pū ana i ka waiwai like me ke kōmole. E pili ana i nā pūmole nā lāʻau lapaʻau e loaʻa i nā mea ikaika e ʻokoʻa i ka Captril, akā lilo i ka pūʻulu o nā ACE inhibitors a, pēlā hoʻi, he kiko like o ka hana therapeutic.

ʻAno like me Cakopa ʻO nā ʻōlelo noi

ʻO Angiopril-25 papa,
Nā papa papa ʻaina
Nā papa paʻi kapoten.

Nā kikowaena o Cebookril mai nā hui o ACE inhibitors ʻo ia nō kēia mau lāʻau lapaʻau:

ʻO nā kīpona Acupro
Nā papa ʻōpiopio
Nā papa ʻaina,
ʻO nā papa papa Bagopril
Burlipril 5, Burlipril 10, Burlipril 20 papa,
ʻO Paola Wazolong,
Nā papaha Hypernick,
Hoplet mau kaleke,
Nā papa papa palapala
ʻO nā kapake Dilaprel,
Nā papa papa lāʻau
Nā papa kuhikuhi Diroton
Zokardis 7.5 a me Zokardis 30 papa,
Nā papa papa Zonixem
Nā papa ʻaila,
Nā papa ʻaina
Nā papa ʻaina Quadropril
ʻO nā papa ʻaina Quinafar,
ʻO nā papa uhi,
Nā papa ʻaila
Nā papa lysacard,
Nā papa lysigamma,
Lisinopril papa,
Nā Lisinotone papa,
Nā papa lysiprex
Nā papa lama,
Nā papa lysoril
Nā papa laka
Nā papaka liten
Methiapril tablet,
Nā papa papa ʻaila
ʻO Moex 7.5 a me Moex 15 mau papa,
Nā papale a me nā kapula,
Nā papa papa perindopril
Nā papa ʻula hāhi Perineva a me Perineva Ku-tab,
Nā papa papa ʻaina
Nā papa ʻramlelo
Nā ʻulaʻula Pyristar,
Pālani kala,
Prestarium a me Prestarium ʻO nā papa,
Nā lapuwale Ramigamma,
Kapoʻi Ramicardia,
Nā papa lāʻau Ramipril
Nā papa ʻaila,
ʻO nā papa papa ʻaina
Nā papa papa renitec
Rileys-Sanovel papa,
ʻO nā papa papa Sinopril
Nā Pahu Nahu,
Uhi ʻia,
Nā papa paʻi,
Nā papa ʻaina,
Nā papa kīlao,
Nā papa kīwī
Nā ʻōlapa Hartil
Nā lapalapa Hinapril,
Nā papa papa ednit
ʻO nā papa ʻaina Enalapril,
Nā papa papa enama
Hoʻopili iā Enap a me nā Pula Pap,
Nā papa lāʻau ikaika
Nā papa lāʻau enapharm,
ʻO nā pōpō pili.

ʻO ka hapa nui o Captril (ma mua o 85%) he kūpono, ma muli o ka hana kiʻekiʻe o ka lāʻau lapaʻau i ka hoʻemi ʻana i ke koko kiʻekiʻe. Hōʻike nā loiloi e hana wikiwiki ka lāʻau lapaʻau a hōʻemi maikaʻi ia i ka ikaika, a laila hoʻomaikaʻi i ka maikaʻi. Hōʻike pū nā loiloi he lāʻau maikaʻi loa ʻo Creensril no ka hōʻemi wikiwiki ʻana i ka piʻi nui ʻana. Akā, no ka lōʻihi o ka hoʻohana ʻana ma ka maʻi hypertension, ʻaʻole Cewareril he ala koho, no ka mea he nui ia o nā hopena ʻokoʻa i ʻike ʻia i loko o nā lāʻau lapaʻau hou aku nei.

He liʻiliʻi kekahi mau loiloi maikaʻi e pili ana iā Creensril a ka mea maʻamau ke kumu o ka hoʻomohala ʻana i nā hopena ʻaoʻao i hoʻokipa ʻole ʻia e ʻae ʻole i ka lawe ʻana i ka lāʻau lapaʻau.

Calailea paha Enalapril?

ʻO Cucksril lāua ʻo Enalapril he mau lāʻau lapaʻau i ka like, ʻo ia nō lākou, ma ka hui like o nā lāʻau lapaʻau a he like pū lākou e like me ka hana. ʻO kēia ke ʻano o ka captopril a me ka enalapril hoʻohaʻahaʻa haʻahaʻa i ke koko a hoʻomaikaʻi i ke kūlana naʻau i ka hiki ʻole o ka puʻuwai puʻuwai. Eia nō naʻe, aia kekahi mauʻokoʻa ma waena o nā lāʻau lapaʻau.

ʻO ka mea mua, me ke ʻano haʻahaʻa o ka hypertension maʻalahi, ua lawa ʻo Enalapril e lawe i hoʻokahi manawa i ka lā, a ua inu ʻia ʻo C zazika 2 i 3 mau manawa i ka lā ma muli o ka lōʻihi o ka lōʻihi o ka hana. Eia kekahi, ʻo ka enalapril ʻoi aku ka maikaʻi o ka mālama ʻana i ka pēpē ma kahi pae maʻamau me ka hoʻohana lōʻihi.

No laila, hiki iā mākou ke hopena i ka enalapril kahi mea makemake maikaʻi loa no ka hoʻohana ʻana i ka wā lōʻihi e mālama ai i ke kahe koko i loko o nā waiwai i ʻae ʻia. A ʻoi a ʻoi aku ʻo Captopaka i kūpono no ka hōʻemi nui ʻana o ka pehu.

Eia nō naʻe, ʻo Captopril, i hoʻohālikelike ai me Enalapril, ʻoi aku ka maikaʻi o ka hōʻeha o ka puʻuwai ma ka hana ʻole i ka naʻau puʻuwai, hoʻomaikaʻi i ke ola o ka nohona, me ka hoʻonui ʻana i ke kino o ke kino a me ke kaumaha, a ke pale aku nei hoʻi i ka make i ka hemahema cardiac abnormalities. No laila, ma ka hihia o ka palaualelo ulu a me nā maʻi naʻau ʻē aʻe, ʻo ka captopril ka mea i makemake i ka lāʻau.
ʻOi aʻe ma Enalapril