Hiki iā Stem Cell ke ho'ōla i ka maʻi maʻi?

I kekahi mau hihia, hoʻāla ʻia ʻo MSC mai ka kiko adipose ka mea i kaulana loa:

• i nā pilikia kahi i hoʻokaʻawale ʻia ai nā heula o nā hematopoietic stem (ʻo kekahi mau maʻi, nā makahiki, nā ʻokoʻa ka hoʻokaʻawale ʻana o mua ma mua)
• i kekahi mau maʻi (vascular, diabetes mellitus), i ka manawa o ka cellular material ihoʻo ia e hāʻawi i nā hana lapaʻau

Nā Pūnaewele Pūnaewele Adipose

ʻO ka kiko o Adipose ka mea iʻoi aku ka maʻalahi o ka lāʻau biololi e hoʻohālikelike ʻia i ka iwi moloporo, ke kumu nui o MSCs. Loaʻa nā MSC e loaʻa mai i ka kiko o adipose e kūpono no ka hoʻohana ʻana ma ka traumatology a me nā orthopedics, ʻoiai lākou e hoʻokaʻawale ʻē aʻe ai i loko o nā papa o ka iwi Eia kekahi, hiki i ka adipose tissue MSCs hiki ke hoʻoulu i ka ulu vascular e pili ana i ka huni o ka vascular endothelial growth factor (VEGF), ka mea e hōʻoia ai i ka hopena o kā lākou hoʻohana ʻana i nā maʻi e like me ka ischemia haʻahaʻa haʻahaʻa.

ʻO nā hoihoi kūikawā immunosuppressive ka waiwai o nā MSCs a me ka hoʻohana ʻana o MSC i ka mālama ʻana i ke ʻano o ka immunopathological, ʻaʻole wale nō ka maʻi nui e like me ka hui graft-versus-host a me ka type 1 diabetes mellitus, akā like nā mea like, e like me nā laʻana, ka pānaʻi maʻi i nā ʻano etiology a me ka hōʻino. ʻIke ʻia nā ʻāpana paleka Mesenchymal (MSC) i hiki ke hoʻoneʻe i ka hana hana a T-lymphocytes, B-lymphocytes, nā cell dendritic a me nā mea make maoli (NK), a me kēia hana e ka loiloi o ka ʻōlelo hoʻopalike.

Ke hana nei kēia mau mea āpau iā MSC no ka mālama ʻana i nā maʻi autoimmune a i ka mua loa, ʻo TYPE 1 DIABETES i nā pākeke a me nā keiki. ʻO kahi hiʻohiʻona koʻikoʻi o MSCs ko lākou immunogenicity haʻahaʻa a, ʻoi aku, i ko lākou hiki ke pale i ka pane ʻana o ke kino, he mea nui loa ia i ka wā e lawe ai i nā ʻano āpau o ka allogeneic transplantations.

Ke hoʻokomo ʻia nei i loko o ka ventricles a i ʻole keʻokeʻo o ka lolo, neʻe ana ka mesenchymal stem cells i loko o ka parenchyma o ka palupalu a nā ʻōnaehana kūʻokoʻa a me ka hopena o nā hua kelepa kelepa a ʻai ʻole paha. Eia kekahi, aia kahi hōʻike o transdifaspiation o MSCs i nā hematopoietic stem cells i loko o ka vitro a ma vivo. Me ka ʻike hohonu hou, i loko o nā noiʻi pilikino, ua hoʻoholo ʻia ka paleke nui loa o ka MSCs, ka mea e hōʻike ana iā ia iho i ko lākou hiki ke hoʻokaʻawale i nā astrocytes, oligodendrocytes, neurons, cardiomyocytes, nā pūnao mākeke hoʻonaninani a me nā ʻōpū mākaukau o nā papa.

I loko o kahi mau noiʻi e pili ana i ka hiki ke transdifferentiation o MSCs i ka vitro a ma vivo, ua hoʻokumu ʻia ka nui o ka progela multintent mesenchymal o ka hua ʻana i ka ʻōpū o ka iwi nā mea pili ʻole i nā laina kelepona e hana ʻia ai ka iwi, cartilage, Musical, nerve a me ka adipose kiko, a me nā tendons a me nā stroma e kākoʻo ana i ka hematopoiesis.

ALOHA, NO KA OE MAKAU ANA NUI O KEKAHI MAU KEKAHI MEA E NOHO ANA NOHO NOHO CELL MATERIAL, MAILE MAKAʻI ANA O KA ʻĀNUI (TRANSPLANTATION), ʻĀNUI WAI HALE O NUI.

Mai ka lā o Ianuali 2015, ʻo ka hopena me nā ʻāpana huelo autologous (nona iho) i hoʻoneʻe ʻia mai ka iwi adipose kahi kūpono, hana kūleʻa me ka ʻole o ka palena o nā makahiki (ʻo ke ʻano wale nō ka paʻakikī o ka iwi adipose).

ʻO kekahi mau mea maʻi, ʻoiaʻiʻo, e ʻimi e loaʻa i ke koho maʻalahi loa no ka hoʻokō ʻana i ke kaʻina hana a me ka "neʻe ʻana ma ka rake like." ʻO ka ʻoiaʻiʻo ʻaʻole kū kū ka ʻenehana. Aia kahi kūlana koʻikoʻi ma ka kanu ʻana o ka moʻomeheu cell no kekahi mau mahina i Belarus a "koke" ma Kina a me kēia wā me ka hana i hōʻoia ʻia ma Thailand a me Iapana. Hoʻopili pinepine mākou e nā poʻe i hāʻawi i lawe mai i ko lākou pā papa palapala i vitro mai Kina a me Hong Kong me ʻole kahi leka uila. E wehewehe wau ʻaʻole ola nā cell stem i loko o kahi kūlana maʻamau i ke mahana maʻamau. Aia nā kuleana koʻikoʻi no ka kanu ʻana, ka manuahi, kahe ʻana, ka lawe a me ka hoʻololi ʻana mai kēia mau lula ʻaʻole hiki ke hoʻokaʻawale ʻia.

Pono ʻoe e makaʻala a ʻike mua i ka hoʻonohonoho āu e kamaʻilio ai. Hōʻike mākou i ko mākou mau maʻi i ka pā microscope a hōʻike i nā haʻawinaʻokoʻa cluster i kēia he mau cell cell. No ke aha la hoi? Aia nā precedents i Moscow, ʻoi aku i kahi hui paʻa, me ka "paona" ʻoi aku ka nui, me ka loaʻa ʻana o nā palapala laikini a me nā ʻae i hōʻoia ʻia, ua hoʻopuka ʻia i kekahi mea i ka mea maʻi, ʻaʻole ka huina.

ʻO ia ke kumu i koho maikaʻi ai mākou i nā hoahana ʻaʻole no nā pepa, akā no nā hopena. Mai makaʻu i ka nīnau! A eia nō (ʻoluʻolu, kūpono no ko mākou ʻāina), ʻo kā ke kino kanaka e kiaʻi pono ana i nā mea a pau i hoʻokomo ʻia i loko o laila. ʻO ka hoʻokomo ʻia ʻana o ka moʻomeheu donor, ʻaʻole ka mea autologous, hiki i kēia manawa ke kū hoʻokahi wale nō ka mana, inā makemake mākou e loaʻa ka hopena me ka hoʻopiʻi ʻole ʻana, a no ka mea maoli hoʻi ke ʻano o ka hoʻohana ʻana i nā hua pā: ka mea kanu, nā holoholona, ​​a me nā mea ʻē aʻe. Auwē, ʻaʻole wau e pīhoihoi - makemake lākou, no ka mea, e hana pinepine ʻia kēlā hoʻolaha.

No ka poʻe makemake i nā kikoʻī e pili ana i ka hiki o nā pūlima lau i loko o ke ʻano maʻi type 1 (hematopoietic):