Pahu palapala o Januvia - nā papa ʻoniʻoni kiʻi kiʻi: biconvex, kahi pōʻai, ma ke ʻano o 25 mg - ke aniani mālamalama me kahi māka beige kukui a me ke kiʻi a "221", ma ke ʻano he 50 mg - beige māmā, me ke kahakaha "112", ma kahi 100 o 100 mg - beige, me ke kahakaha "277" (14 pcs. in blisters, in a cardble of 1, 2, 4, 6 or 7 blisters).

Kāleka i kēlā me kēia 1 papa:

• kaha waiwai: sitagliptin phosphate hydrate - 32.13 / 64.25 / 128.5 mg (kahi mea e kūlike ai me ka ʻike o sitagliptin - 25/50/100 mg),
• ʻO nā mea kōkua: microcrystalline cellulose, unmilled calcium hydrogen phosphate, croscarmellose sodium, magnesium stearate, sodium stearyl fumarate,
• palauo film: ma ke ʻano o 25 mg - Opadrai II Pink 85 F 97191, ma ke ʻano o 50 mg - Opadrai II Light beige 85 F 17498, ma ke ʻano he 100 mg - Opadrai II Beige 85 F 17438 (polyvinyl alkohol, titanium dioxide, polyethylene glycol 3350, talc, ka mea hao ka oxide i ka melemele, ka hao ka hao i ka pōpoki).

Lapaʻau lāʻau

ʻO ka hana ikaika o Januvia ʻo sitagliptin, he mea paʻa i koho maikaʻi loa o ka huina DPP-4 (dipeptidyl peptidase-4), i manaʻo ʻia no ka mālama ʻana i ka maʻi mellitus type 2. Ma nā hua lāʻau a me nā hana pharmacological, ʻokoʻa ka sitagliptin ʻokoʻa o ka GLP-1 analogues (like me ka peptide-1 peptide-1), ka hua o ka sulfonylurea, insulin, biguanides, agonist γ-receptor (hoʻālaʻi ʻia e ka peroxisome proliferator - PPAR-γ), α-glycosidase inhibitors, analogues amilone. ʻO Sitagliptin, e hoʻokaʻa ana i ka DPP-4, a laila e hoʻonui ai i ka hoʻoulu ʻia ʻana o GLP-1 a me HIP (ka pona o ka insulinotropic e hilinaʻi nei) - ʻelua mau kāne i ʻike ʻia, he ʻāpana o ka ʻohanamikini, kahi i hūnā ʻia i loko o ka ʻōpū no 24 mau hola, a me ke kiʻekiʻe o ka hoʻonui i ka pane ʻana i ka ʻai kai. ʻO ka incretins he ʻāpana o ka pūnaehana physiological kūloko no ka hoʻoponopono ʻana i ka homeostasis glucose, ua kōkua lākou i ka synthesis o ka insulin a me kona ʻimi ʻana e nā pancreatic β-cells ma muli o ka hōʻailona ʻana i nā hana intracellular e pili ana me ka cyclic AMP (adenosine monophosphate), me kahi maʻamau a i ʻole ka nui o ke koko.

Hoʻopili ʻia ka GLP-1 i ka hoʻonui ʻia ʻana o ka ʻaihue o ka glucoseagon e nā pona o ka pancreas. ʻO ka emi ʻana o nā pae glucagon i ka wā o ke hoʻonui ʻana o ka hoʻomehana i ka insulin e pale i ka hana o ka glucose ma o ka ate, kahi e hoʻoemi ai i ka glycemia.

Ma ka hihia o ka haʻahaʻa haʻahaʻa o ka toto, ʻaʻole i ʻike ʻia ka hopena o ka incretins ma ka synthesis o ka insulin a me ka huna ʻia ana o ka glucagon, ʻaʻole lākou e pili i ka hoʻokuʻu ʻana o glucagon i ka pane ʻana i ka hypoglycemia. Ma ka vivo, ʻo ka enzyme DPP-4 ke kaupalena i ka hana o ka incretins, e hoohiolo koke iā lākou a hoʻokaʻawale iā lākou i nā hana hana.

ʻO Sitagliptin, e pale ana i ka hana pono o DPP-4, ka mea e pale ai i ka hydrolysis o ka incretins, e hoʻonui ana i ka plasma o nā ʻano hana a GLP-1 a me HIP, e hoʻonui ana i ka hoʻokuʻuʻana i ka glucose o ka insulin a kōkua i ka hōʻemi i ka huna ʻana o ka glucagon. Ma ke ʻano 2 diabetes mellitus me ka hyperglycemia, ke ʻano o ka hoʻoponopono ʻana i ka mea huna o ka insulin a me ka glucoseagon e alakaʻi nei i ka kaohi ʻana o ka maʻi o HbA1c (hemoglobin glycosylated) a me kahi hoʻohaʻahaʻa i ka pae o ka glucose i hoʻoholo ʻia ma ka ʻōpū ʻole a ma hope o ka hoʻāʻo ʻana.

ʻO ka lawe ʻana i kahi pākahi hoʻokahi o ka helu o ka maʻi kanesa me ka maʻi ʻaʻa o ka lā 2 me ka pale ʻana i ka hoʻoneʻe ʻana o ka huina DPP-4 no 24 mau hola, ma ke ʻano o ka pae ʻana o ka hoʻoulu ʻia ʻana o GLP-1 a me HIP i hoʻonui ʻia i ka manawa 2-3, hoʻonui ʻia ka pilina o ka insulin a me C-peptide, a hoʻemi. ʻO ka hoʻoneʻeʻana o ka glucose glucose, ka wikiwiki ʻana o ka glycemia a ma hope o ke hōʻemi ʻana o ka hoʻouka ʻana a i ʻole ka ukana ʻai.

Lapaʻau lāʻau

ʻO nā kānāwai kinetic o nā hana kūlohelohe a me nā kaʻina ola e kū nei me ka sitagliptin i ke kino o nā mea olakino a me nā mea maʻi me nā maʻi diabetes mellitus type 2 ua aʻo nui. ʻO nā hiʻohiʻona no nā mea hana olakino olakino ma hope o ke alakaʻi wahaʻana o 100 mg o ka sitagliptin: kaʻohi - wikiwiki, TC waiwai_max (ka manawa e hiki ai i ka lōʻihi o ke kau ʻana) - 1 mau hola mai ka manawa o ka hoʻokele ʻana, ʻo AUC (wahi ma lalo o ka pihi “mākaukau”) - 8.52 μmol / hola, e hoʻohālikelike ana kēia mākaʻi i ka ʻōlelo i lawe ʻia, C_max - 950 nmol / L, T_1/2 (awelika hapalua-ola) - mau hola 12.4. ʻO ka AUC o ka sitagliptin ma hope o ka hopena hou o 100 mg o ka lāʻau ma hope o ka hōʻea ʻana i ka moku e hoʻohālikelike ma hope o ka lawe ʻana i ka hopena mua i hoʻonui ʻia e

14% Hōʻalo ʻia Intra- a intersubject vari ma AUC.

Pharmacokinetic ʻano o Januvia:

kapili: he mākaukau o ka bioavailability piha loa o sitagliptin

87%, koena hoʻomalu o ka lāʻau lapaʻau me ka ʻai momona ʻaʻole i hoʻopilikia i kāna pharmacokinetics, hoʻohele: ma hope o hoʻokahi pākahi o nā lāʻau lapaʻau ma kahi o 100 mg, ʻo ka nui o ka nui o ka hoʻoili ʻana o ka sitagliptin i kālā i loko o ka waiwai maikaʻi i

198 l. ʻO ka hapa liʻiliʻi o ka protein protein i haʻahaʻa loa (

38%), metabolism: a hiki i ka 79% o sitagliptin i hoʻopau ʻia e nā keiki i loli ʻole, he wahi liʻiliʻi wale nō ia o nā mea i hoʻomālikelike ʻia ma hope o 14 sitagliptin C-hōʻailona ʻia.

Ua wehe ʻia ka 16% o ka lāʻau radioaktif ma ke ʻano he metabolites, ua loaʻa nā 6 metabolites o sitagliptin i loko o nā wahi he nui, ʻo ka loaʻa ʻole o ka hopena DPP-4 i hoʻopaʻa ʻia, excretion: ma hope o ka 14 sitagliptin C-kapa ʻia i kālai ʻia i ke kumuhana olakino, a hiki i ka 100% o ka lālani i lawe ʻia ma loko o hoʻokahi pule. mai ka manawa o ka hoʻokele e like me kēia: ma o ka mau palupalu - 13%, ʻōpū - 87%. T_1/2 i ka wā e lawe ʻia ai i ka maʻi ma kahi o 100 mg

12.4 h, kahi hoʻomaʻemaʻe renal

Nā hōʻailona no ka hoʻohana ʻana

• monotherapy: nā mea maʻi e hahai ana i kahi meaʻai kūikawā a loaʻa i ka hana olakino e kuhikuhi ana me ka lāka e hoʻomaikaʻi ana i ka mana glycemic in type 2 diabetes,
• Hoʻohui hui: i hui pū me ka metformin a i ʻole PPARγ receptor agonists (thiazolidinediones) i kuhikuhi ʻia no nā mea maʻi me ka maʻi diabetes mellitus type 2 i mea e hoʻomaikaʻi ai i ka mana glycemic, ma ke ʻano o ka maikaʻi ʻole o ka meaʻai a me ka hana kino ma ka hui pū ʻana me monotherapy.

Nā Hoʻohui

• maʻi diabetes type 1
• maʻi maʻamau ketoacidosis,
• ka manawa hāpai a me ka lactation (lactation),
• na keiki a me na opio malalo o na makahiki 18
• hypersensitivity o kekahi o nā lāʻau o ka lāʻau.

Nā contraindications e pili ana: pono e mālama ʻo Iāvia me ka akahele i ka hiki ʻole o ka renal. ʻO nā mea maʻi me ke kaulike a me ka pilikia ʻole a me ka pathology renal i ke kahua hoʻonā e koi ana i ka hemodialysis e koi ai i ka hoʻoponopono ʻana o sitagliptin.

Nā ʻōkuhi no ka hoʻohana ʻana iā Januvia: ke ʻano a me ka helu ʻana

Lawe ʻia nā papa ʻaia o Hoavia, me ke ʻano o ka ʻaina.

ʻO ka dosage i manaʻo ʻia no ka monotherapy, a me ka hoʻohui pū me ka metformin a i kahi agarist PPARγ (thiazolidinediones), he 100 mg hoʻokahi i ka lā.

Inā poina e ka mea maʻi ke lawe i kahi paila hou, pono nō e lawe koke ʻia, ma hope o kona hoʻomanaʻo ʻana e pili ana i ka ʻoki ʻana i ka ʻimi, akā ʻaʻole i ʻae ʻia ka loaʻa ʻana o kahi pālua.

Nā hopena hopena

ʻO Jasonvia ma kahi monotherapy a me ka hui pū me nā lāʻau hypoglycemic ʻokoʻa ʻē aʻe ʻoluʻolu loa. ʻO ka ulu pinepine ʻana o nā hopena maikaʻi ʻole, a me ka neʻe ʻana o ka sitagliptin ma muli o nā hopena kūpono ʻole, e like me nā haʻawina loiloi, ua like nō ia me nā mea i kākau ʻia ma muli o ka lawe ʻana i kahi placebo.

ʻO nā hanana pōʻino ʻole i ka pilina me ka hoʻohana ʻana i ka sitagliptin i loko o kahi lā he 100 a me 200 mg, akā he mau mea hou aʻe ma mua o nā mea maʻi i loaʻa i kahi pletebo (≥ 3% o nā hihia): nā maʻi ʻeha o ka ʻōpū o ka ʻōpū, nasopharyngitis, ʻeha, ʻeha, ʻohiʻohi.

ʻO nā manaʻo ʻē aʻe iā Januvia:

• ʻO GI tract (gastrointestinal tract): ʻeha o ka ʻōpū, ke kuʻi, ka luaʻi, ke kaʻa ʻana, ka maʻi ʻeha,
• ka ʻikepili ʻōlapa (ʻaʻole i manaʻo ʻia he koʻikoʻi): kahi hōʻemi iki i ka wa uric (ʻaʻole i hoʻopaʻa ʻia nā hihia o ka gout), kahi hōʻemi i ka neʻe o ka nui o ka phosphatase alkaline, ka mea i hui pū ʻia me ka liʻiliʻi o ka hapa o ka iwi o ka alkatine phosphatase, he hōʻemi iki i ka manaʻo o nā leukocytes ma muli o ka hoʻonui o ka nui o ka neutrophils (hanana. ʻike ʻia i ka hapa nui o nā haʻawina, akā ʻaʻole ma nā hihia a pau)
• pūnaehana cardiovascular: ua nānā ʻia i nā loli nui i nā hōʻailona nui a me nā electrocardiograms (ECG), me ka kikowaena QTc.

Ke keu

Ua hōʻike ʻia nā haʻawina Clinical me nā limahana olakino e sitagliptin i loko o hoʻokahi mauʻu o 800 mg i ʻomaʻomaʻo maikaʻi ʻia. I hoʻokahi hihia, ua ʻike ʻia kahi hoʻololi hoʻololi iki ʻia e ka maʻi iki ma ke kikowaena QTc. ʻO ka horomoana o nā lā i kēlā me kēia lā i ʻoi aʻe o ka 800 mg i loko o nā kānaka ʻaʻole i aʻo ʻia.

Ma ka hihia o ka overdose, ua manaʻo ʻia e lawe ʻia nā hana kākoʻo paʻa: ka lawe ʻia ʻana o nā koena o nā mea hoʻohana ʻole ʻia mai ka gastrointestinal tract, ka mālama mau ʻana i nā hōʻailona koʻikoʻi, me ka ECG, me ka koho ʻana i ka mālama maʻi, inā pono.

Ua hoʻohālikelike ʻia ka lāʻau lapaʻau (no ka hālāwai hemodialysis 3-4 mau hola, e like me ka nānā ʻana i nā lāʻau lapaʻau, ʻo 13.5% wale nō ka nui o ka nui e hoʻopau ʻia mai ke kino). Me ka pono lāʻau lapaʻau i hōʻoia ʻia, hiki ke kuhikuhi ʻia i ka dialy lōʻihi. ʻAʻohe mea ʻikepili i ka hopena o ka wehe ʻana o ka sitagliptin i ka wā peritoneal dialysis.

Nā ʻōlelo kikoʻī

Wahi a nā haʻawina loiloi, ma muli o ka lawe ʻana iā Januvia ma kahi lāʻau monotherapy a i ʻole ma ke ʻano o ka hoʻomaʻamaʻa ʻana i ka hopena me ka metformin / pioglitazone, hypoglycemia i hoʻomohala i nā mea maʻi me ka pinepine e like me kēlā me ka pletebo.

ʻO ka hoʻohana pū ʻana o ka lāʻau lapaʻau me ka hui pū me nā lāʻau e hiki ai i ka hypoglycemia, no ka laʻana, me ka insulin a i ʻole nā ​​wānana sulfonylurea.

ʻŌpū a me ka lactation

Ma muli o ka nele o nā ʻike mai nā noi i hoʻopaʻa ʻia e pili ana i ka palekana a me ka hana pono o ka lāʻau lapaʻau i nā wahine hāpai, ʻo Januvius, e like me nā mea āpau hypoglycemic no ka hoʻokūkū waha, ʻaʻole ʻia ka hoʻohana ʻia i ka wā hāpai.

ʻAʻohe ʻikepili i ka hoʻokuʻu ʻana o ka sitagliptin i ka wā lactation, no laila ʻaʻole i kuhikuhi ʻia ka lāʻau lapaʻau i ka wā o ka ʻōpū.

Me ka hana pūnāwai paʻa ʻole

ʻO nā mea maʻi me ka ʻōpū o ka renal e pono i kahi hoʻoponopono o Pauvia, no ka mea ke noi ʻia e hana ʻia kahi loiloi o ka hana hana i mua o ka hoʻomaka ʻana o ka papa, a laila hana hou ʻia i ka papa o ka hopena.

Hoʻoponopono ke ʻano o ka maʻi helu ʻana i ka palena o ka hiki ʻole o ka hana a i ʻole ka hana hana a me ka hana hoʻokele (QC):

• ʻOi aku ka hopena o ka renal male ʻole, CC> 50 ml / min (serum creatinine concentrization: i nā kāne - e emi iho ma mua o 1.7 mg / dl, i nā wahine - ʻaʻole i emi iho ka 1,5 mg / dl): ʻaʻole pono ka hoʻoponopono hoʻoponopono.
• ka nui o ka holomua o ka renal, CC mai 30 a 50 ml / min (kākūlele me ka serum creatinine: i nā kāne - 1.7-3 mg / dl, i nā wahine - 1.5-2.5 mg / dl): i kēlā me kēia lā - 50 mg ma 1 pākaʻi
• pilikia hōʻeha nui loa, QC

Ka hoʻonaʻauao: ʻO ke Kulanui Kauka Kahikole ma Moscow i kapa ʻia ma hope o I.M. Sechenov, hoʻolālā "General Medicine".

Hōʻike nui ʻia ka ʻike e pili ana i ka lāʻau lapaʻau, i hoʻolako ʻia no ka hana ʻike a ʻaʻole hoʻololi i nā ʻōlelo aʻoaʻo. Hoʻopilikia ka lāʻau-pono iā ia ke olakino!

Ua hana ʻia nā ʻepekema mai University University o Oxford he nui o nā haʻawina, i ka wā i hele ai lākou i ka hopena ʻo ka vegetarianism hiki ke hoʻopōʻino i ka lolo o ke kanaka, no ka mea i ka hoʻohaʻahaʻa i kāna nui. No laila, ʻōlelo ʻo nā kānaka ʻepekema i ka haʻalele ʻole ʻana i ka iʻa a me ka ʻiʻo i kā lākou meaʻai.

Inā hāʻule ʻoe mai kahi hoki, ʻoi aku ka ʻoi aku o kou ʻāʻī ma mua o ka hāʻule ʻana mai kahi lio. Mai hoʻāʻo wale e hōʻole i kēia ʻōlelo.

Aia nā mea lapaʻau maʻi keu nui loa, e like me ka nānā ʻana o nā mea nānā. Ma ka ʻōpū o kahi mea hoʻomanawanui e loaʻa ana i kēia mania, ua loaʻa nā mea 2500 mau mea ʻē.

Ke "holo" nei ke koko o ke kanaka ma o nā moku ma lalo o ka pīhoihoi nui a, inā e hoʻokaʻawale ʻia kona kūpaʻa, hiki ke pana i ka 10 mau mika.

Ua hoʻopaʻa ʻia ke kiʻekiʻe wela o ke kino ma Willie Jones (USA), i hōʻike ʻia i ka haukapila me ke ʻano 46.5 ° C.

Ke kihi nei nā mea aloha, e nalo ana kēlā me kēia o 6.4 kcal i hoʻokahi minuke, akā i ka manawa like a hoʻololi lākou i ka like o 300 mau like o nā like ʻole.

Ua hana ʻia ka vibrator mua i ka kenekulia 19. Ua hana ʻo ia ma ka mokuahi kahi i manaʻo ʻia no ka mālama ʻana i ka hysteria wahine.

I ka hoʻāʻo e hoʻokuʻu aku i ka mea maʻi i waho, ua holo lōʻihi loa nā kauka. No laila, eia no kekahi, ʻo Charles Jensen kekahi i ka wā mai 1954 a 1994. pakele i ʻoi aku ma kahi o 900 hana neoplasm hana hoʻoiho.

ʻAʻole loaʻa nā manamana lima pilikino wale nō, akā he ʻōlelo nō hoʻi.

ʻOi aku ka ikaika o nā iwi kanaka ʻehā ma mua o ka konihi.

Hoʻohana ʻia ka poʻe maʻamau i ka ʻaina kakahiaka maʻamau no ka liʻiliʻi loa.

Ma UK, aia kekahi kānāwai e like me ka mea e hiki ai i ka mea maʻi ke hōʻole e hana i ka hana ma ka mea maʻi inā ulaula a i ke kaupaona ʻana. Pono ke kanaka e haʻalele i nā hana ʻino, a laila, ʻaʻole paha, ʻaʻole pono ia e kāpili ʻia.

ʻO nā kāmera ʻo nā maʻi maʻi maʻi maʻamau i ka honua a hiki i ka maʻi ke hiki ʻole ke hoʻokūkū.

I 5% o nā mea maʻi, ʻo ka clomipramine antidepressant e hōʻeha i kahi orgasm.

ʻO ka maʻi ʻemi loa ka maʻi o Kuru. Ua maʻi wale nō nā lālā o ka ʻohana Fore ma New Guinea. Make ka mea maʻi. Ua manaʻoʻiʻo ia ke kumu o ka maʻi i ʻai ai i ka lolo o ke kanaka.

Ua hoʻonui nui ʻia ka nui o nā limahana hana i ke keʻena hana. ʻO kēia ʻano ka hiʻohiʻona nui o nā kūlanakauhale nui. Ua hoihoi ʻia ka hana a ke keʻena ma nā kāne a me nā wahine.

Nā ʻōkuhi no ka hoʻohana ʻana iā Januvia, ke ʻano

Lawe ʻia ka lāʻau e pili ana i nā mea ʻole. I ka hihia e nalowale ana i ka lāʻau e pono e lawe ʻia i ka hiki. ʻAʻole ʻae ʻia ka hoʻohana ʻana o kekahi pālua ʻelua.

Nā ʻōlelo kuhikuhi i hoʻohana ʻia no ka hoʻohana ʻana i ka pauka ʻaʻi ovia me ka monotherapy, a me ka hoʻohui pū me ka metformin a i ʻole ka aganist PPARγ (thiazolidinediones) - 1 papa 100 mg 1 manawa i kēlā me kēia lā.

Me ka CC - 30-50 ml / min, nā mea hana i ka plasma 1.7-3 mg / dl (no nā kāne), 1.5-2.5 mg / dl (no nā wahine), hōʻemi ʻia ka nui i ka 50 mg 1 i kēlā me kēia lā.

Me ka CC ma lalo o 30 ml / min, ʻo ka mea hana plasma iʻoi aku ma mua o 3 mg / dl (i nā kāne) a ʻoi aku ka nui o ka 2.5 mg / dl (i nā wahine), pū nō hoʻi i ka poʻe maʻi ma ka laiki o ka haki ʻana ʻole o ka pilikia ʻole e koi ai i ka hemodialysis, aia ka nui o ka 25 mg / 1 manawa. i kēlā lā i kēlā lā (ʻoiai ʻole o ka manawa o hemodialysis).

Nā ʻōlelo kikoʻī

I loko o nā hoʻokolohua lapaʻau o ka lāʻau lapaʻau, ʻo ka hanana o ka hypoglycemia i ka wā o kona hoʻohana e like me ka placebo.

ʻO nā mea maʻi me ka maʻi hepatic compensated e koi ʻia e hoʻololi i ka hewa o ka lāʻau.

Nā hopena hopena

Hoʻomaopopo ka ʻōlelo aʻo i ka hiki ke hoʻomohala i nā hopena ʻaoʻao aʻe i ka wā i kuhikuhi ai iā Januvius:

• ʻO nā maʻi ʻeha o ke ea, nasopharyngitis.
• Laumapa.
• ʻEha ka ʻōpū, ke nānā ʻana, ka luaʻi ʻana, ka ʻōpū.
• Naona Arthralgia.
• Hypoglycemia.
• Nā huaʻōlelo o ka limahana: kahi mahuahua o nā kiko o ka uric acid, ka hoʻohaʻahaʻa iki ʻana i ka neʻe o ka alkatine phosphatase, he hoʻonui i ka nui o nā neutrophils.

Nā Hoʻohui

Hoʻohui ʻia ia e kuhikuhi iā Januvius i kēia mau pilikia aʻe:

• ʻAno maʻi type 1
• ʻŌpū a me ka lactation
• Maʻi molaʻi
• Hypersensitivity i nā māhele o ka lāʻau lapaʻau,
• He 18 makahiki.

Kuhi me ke akahele:

Ke keu

I ka hihia o kahi overdose, e loli paha ka puʻuwai o ka puʻuwai.

Inā hōʻike ʻia nā hopena ʻaoʻao a i loaʻa paha nā hōʻailona hōʻailona ʻē aʻe, pono e kūkā i kāu kauka no ke kōkua therapeutic kōkua.

Nā hōʻike o Januvius, ke kumukūʻai i nā lāʻau lapaʻau

Inā pono, hiki iā ʻoe ke kahuli i nā papa ʻaʻi o ka ovia me ka analogue o ka mea ikaika a i ʻole ka hopena therapeutic - ʻo ia kēia mau lāʻau.

Ke koho ʻana i nā mea kikoʻī, pono ia e hoʻomaopopo i nā ʻōlelo aʻo no ka hoʻohana ʻana iā Januvia, ʻaʻole pili ʻia ka kumukūʻai a me nā loiloi i nā lāʻau lapaʻau o nā hopena like. He mea nui ia e kamaʻilio pū me ke kauka kauka a ʻaʻole hoʻi e hana i kahi loli kūʻokoʻa kūʻokoʻa.

Kumukūʻai ma nā lāʻau lapaʻau Lūkia: ʻO ʻOvia 100 mg 28 papa - mai 1570 a 1699 rubles, e like me 703 mau lāʻau lapaʻau.

Store ma 30 ° C. Mai mālama i nā keiki. ʻO 2 mau makahiki kahi ola.

ʻO ka lāʻau Hypoglycemic Januvia - nā ʻōlelo hoʻohana no ka hoʻohana ʻana

Heʻokoʻa loa nā lāʻau lapaʻau no ka maʻi maʻi maʻi. Hoʻopili kēia me ka lāʻau lapaʻau ʻO Lonvia.

ʻO ka pōmaikaʻi o ka mālama ʻana me ia e pili pono i ka hoʻokō ʻana i nā ʻōkuhi, no laila e ʻike ʻoe i ke ʻano o kāna mau lula.

Hoʻohana ʻia kēia huahana ma ka Netherlands. ʻO ia kahi papa me ka hopena hypoglycemic, i hoʻokumu ʻia ma ke kumu o Sitagliptin. Hiki ke kūʻai ʻia aku ka lāʻau lapaʻau ma o ka lāʻau lapaʻau wale nō.

Hōʻike, hoʻokuʻu i ke ʻano

ʻO ka māhele nui o ka lāʻau sitagliptin. ʻO kāna hana kāna e hoʻomaʻamaʻa ai i kēia lāʻau lapaʻau i ka maʻi maʻi. Ma loko o nā lāʻauʻai hiki ke loaʻa nā ʻano kālā - e like me ka nui o nā mea ikaika. Aia paha he 25, 50 a me 100 mg.

Koho ʻia nā mea kōkua a pau iā ia:

• sodium stearyl fumarate,
• kalekaʻiʻawa pākūkū
• mikuleka
• sodium polio
• makee
• macrogol
• titanium hone
• ka leʻaleʻa talcum.

Ua puni nā papa, biconvex. Kele be kona kala, kahakaha ʻia me "277". Hoʻokomo ʻia lākou ma nā pā contour ma ka nui o 14 pcs. Aia paha i nā mea pahu kāwele paha i kekahi mau pahu (2-7).

Pharmacology a me ka pharmacokinetics

ʻO ka hopena o ka lāʻau lapaʻau ma ke kino ma muli o nā ʻano o kāna hana ikaika. ʻO ka sitagliptin (ka ʻōlelo i loko o ke kiʻi) e hāʻawi i ka hana ikaika o ka insulin e ka pancreas, ma muli o ke kō i loaʻa mai ai ke kō i loko o ke kino e hoʻopuka koke ʻia i nā kiko.

ʻO ka hoʻonui ʻana o ka pae o ka synthesis o ka insulin e hoʻopā i ka puʻuwai, e pale ana i ka hoʻoulu ʻana i ka glucose nui loa. Hāʻawi kēia i ka hoʻolilo o ke kō i loko o ke koko o kahi maʻi maʻi maʻi a hoʻomaikaʻi i kona pono.

Hoʻopuka koke kekahi o nā mea waiwai. Ua hiki i kēia hanana kona hiki i ka hopena kūpono e pili ana i hoʻokahi hola ma hope o ka hoʻopauʻana iā Januvia a lōʻihi i hoʻokahi mau hola 3. Eia hou ka hoʻomaka ʻana o ka waiwai e hoʻohemo iki ʻia mai ke kino, a nawaliwali kona hopena.

ʻO ke kamaʻilio me nā protein protein e hana i kahi liʻiliʻi o sitagliptin. Me ka hana o ka metabolism, ʻaʻole hoʻohuli i ka loli. Hoʻohana ʻia ka ʻāpana nui i kahi ʻāpana nui a nā keiki. Hoʻopili ʻia ke koena i koe me nā nūpepa.

Nā hōʻailona a me nā contraindications

Wahi a nā ʻōlelo kuhikuhi, kōkua kēia lāʻau lapaʻau me ka maʻi diabetes type 2. Hiki ke hoʻohana pū i ka hui me nā lāʻau ʻē aʻe a i ʻole ka monotherapy, i hoʻohui ʻia me kahi papa meaʻai.

Akā ʻaʻole ka manaʻo o ka maʻi ʻana e hoʻomaka koke ʻoe e lawe i kēia lāʻau lapaʻau. Pono ka lāʻau e hoʻokaʻawale i ke kauka ma hope o ka hoʻokolokolo a wehewehe i ka ʻōlelo kikoʻī o nā lula o ka hoʻohana ʻana. He koʻikoʻi kēia no ka mea ua helu o contraindications ʻo Januvia, hiki iā ia ke hana koʻikoʻi ke hoʻohana.

I waena o lākou e ʻōlelo nei:

• ketoacidosis o ka maʻi maʻi,
• maʻi diabetes type 1
• ke hoʻomaloka ʻana i ka hakuhelu,
• keiki a me ʻōpio,
• hapai
• ka wā aloha.

Aia kekahi mau kūlana e hiki ke hoʻohana ʻia ka huahana, akā koi ʻia ka mālama. I ka manawa pinepine, ua hāʻawi ʻia nā hana kūikawā no nā poʻe maʻi me ka maʻi ʻeha.

Hiki i kekahi loea ke kākau iā Januvia iā lākou, akā pono ʻo ia ke kuleana no ka koho o ka ʻano o ka lāʻau lapaʻau. Eia kekahi, pono e nānā maʻamau i ka hana o nā keiki.

ʻO nā maʻi maʻi kūikawā

No kekahi mau mea maʻi, ʻaʻole ia e aʻo e hoʻohana i nā ʻōpiopio maʻamau. Loaʻa iā lākou kahi ʻano kūikawā. ʻAʻole ʻae ʻia nā luna o kekahi mau kulana e loaʻa iā Januvia; e mālama ʻia ka hana kūikawā e pili ana i kekahi.

1. Nā wahine hāpai. ʻAʻole he ʻike e pili ana i ka hopena o ka lāʻau lapaʻau i kēlā mau maʻi, no ka mea ʻaʻole i lawe ʻia nā noi ʻana ma kēia wahi. No ka hōʻalo ʻana i nā pilikia kīnā, me ka maʻi maʻi i nā wāhine hāpai, kuhikuhi nā kauka i nā lāʻau lapaʻau ʻē aʻe.
2. Nā makuahine hānai. ʻAʻole ʻike ʻia inā hoʻokomo ʻia ka mea ikaika i ka waiū umauma. I kēia mea, paʻakikī ke ʻike pehea e hiki ai i kēia mea ke hoʻopilikia i kahi pēpē. Wahi a, me ka lactation, hiki ʻole ke hoʻohana iā Januvia.
3. Na keiki a o ka opio. ʻAʻole hāʻawi ka ʻōlelo no ka lāʻau lapaʻau no ka mālama ʻana o nā mea maʻi ma lalo o nā makahiki 18. No laila, mālamaʻia ka maʻi diabetes i nā mea maʻi me nā ʻano ala ʻē aʻe.
4. Poʻe kānaka. ʻAʻole ʻike ʻia ʻo Sitagliptin i mea pōʻino no ka poʻe ma kēia ʻāpana. Ke hana ʻole nei i nā pilikia olakino, ʻae ʻia ka papa maʻamau no ka lawe ʻana i ka lāʻau lapaʻau, ʻoiai me ka hiki ʻana o nā loli e pili ana i ka makahiki. Akā pono e mālama ke kauka i ke ʻano o ka lāʻau lapaʻau.

I nā kūlana āpau āpau, ke hilinaʻi nei i ke kiʻi o ka maʻi i ka maʻi a me nā hiʻohiʻona o ke kino.

Nā Kūleʻa Kūʻai a me nā Analog

Inā ʻaʻohe maʻi wale nō ka maʻi maʻi, a laila pono ka hoʻomaʻemaʻe ʻana i ka mālama kūikawā. ʻAʻole hiki i nā lāʻau lapaʻau ke hoʻohui pū me kekahi me kekahi, i kekahi manawa i ka hoʻohana pū ʻana i kekahi mau lāʻau e alakaʻi i ka wehe ʻana i kā lākou hana.

Ua manaʻo ʻia ʻo Iāvia e palekana i kēia ʻike, ʻoiai he liʻiliʻi nā hopena o nā lāʻau lapaʻau ma luna.

Hiki i nā loli liʻiliʻi ke hana me ka hoʻohana pinepine ʻana o kēia lāʻau lapaʻau me ka digoxin a me nā cyclosporine. Wahi a ke ʻano o ke ʻano ʻana o kēia mau loli, ua koho ʻia ke kaona.

Ma muli o kēia kumukūʻai e kūʻai nui ʻia, hiki i nā mea maʻi ke noi ʻia e hāʻawi iā lākou i nā hōʻiliʻuku loa.

Koho nā poʻe loea mai lākou iho:

Pono ke kauka lāʻau e kuhikuhi i kekahi o kēia mau lāʻau ma hope o ka hoʻomaikaʻi ʻana i ka mea maʻi. Inā ʻaʻole, hiki ke hoʻonāukiuki ʻia ka hoʻomohala ʻana. He mea nui hoʻi ia e hahai i nā lula no ka lawe ʻana i kahi maʻi i hoʻokahi lāʻau i kekahi.

ʻO ka manaʻo o nā kauka a me nā maʻi

I ka hoʻoholo ʻana e nā loiloi, maʻa pinepine nā kauka i kuhikuhi iā Januvia ma muli o ke kumukūʻai nui o ka lāʻau lapaʻau. I waena o nā mea maʻi, ʻaʻole kaulana loa ka lāʻau lapaʻau ma muli o ke kumukūʻai kiʻekiʻe a me nā hopena hopena.

Ua koho pinepine au iā Januvius. ʻO kēia kahi lāʻau lapaʻau maikaʻi e hoʻohaʻahaʻa i nā pae glucose. Akā he nui loa ia, a hōʻole pinepine nā mea maʻi. Hāʻawi ʻia i nā mea nāna e hoʻolako ʻole ʻia a i ke kumu kūʻai paha, no ka mea he mau hopena kūpono lākou. I kēia manawa, ma ke ʻano mau nei, ʻelua wale nō o kaʻu mau maʻi e hoʻohana ai i kēia lāʻau lapaʻau. Ua ʻoi aku ʻo ia iā lākou ma mua o nā lāʻau lapaʻau ʻē aʻe.

ʻO Elena Dmitrievna, ke kauka

E hoʻohana wale i kēia lāʻau lapaʻau ma hope o ka noiʻi ʻana i ka kikoʻī. Hoʻokomo nā contraindications e pili ana i nā hopena koʻikoʻi, maʻi ka poʻe maʻi ma nā hopena hopena, a ua make nā hopena. Akā ʻo ka mea nāna e kūpono ka hōʻuluʻulu ʻana, e hoʻopiʻi wale ana lākou no ka uku kiʻekiʻe. Loaʻa pakahi.

ʻO Alexander Borisovich, ke kauka

ʻAʻole au i lōʻihi i ka lōʻihi o Januvia. Maikaʻi ka lāʻau, ke kō ka mālama ʻana i ka maʻamau a me nā hopena ʻole. Akā ʻoi loa ke kumukūʻai, makemake wau i kahi ʻatikala haʻahaʻa.

I ka mua ua makemake wau e haʻalele i kēia lāʻau lapaʻau. Ua pilikia au e ka insomnia a me ka nawaliwali mau ʻana ma muli o ka hiamoe ʻole. Ua hoʻi hou ka Sugar i ka maʻamau, akā ua ʻino loa wau. A laila ua laila - ʻike ʻia ke kino e hoʻohana ʻia ma ke ʻano. ʻĀnō ua pono nā mea a pau.

Hoʻopilikia ʻia ke kumukūʻai o Januvia i ka neʻe ʻana o ka hana ikaika a me ka helu o nā ʻāpana i loko o ka mōkī. No kahi pākahi me kahi maʻi o Sitagliptin i 100 mg (28 pcs.), E hāʻawi ʻoe i ka 2200-2700 rubles.