Nā palapala ʻano: pani ʻ -lelo ʻlelo 1 papa pāahī-kiʻi e pili ana: Kāleka 2.5 mg + 500 mg: Nā ʻāpana hana: glibenclamide - 2,5 mg, metformin hydrochloride - 500 mg. Kernel: sodium croscarmellose - 14.0 mg, povidone K 30 - 20,0 mg, cellulose microcrystalline - 56.5 mg, ka pākuʻi magnesium - 7.0 mg. Ka: opadry OY-L-24808 ulū - 12,0 mg: monabolio lactose - 36,0%, hypromellose 15cP - 28.0%, titanium dioxide - 24.39%, macrogol - 10,00%, kaio hao ka melika, 1, 30%, ulaula pōpika hao - 0.3%, hao ʻele pōpoki - 0,010%, wai maʻemaʻe - qs Dosis 5 mg + 500 mg: Nā ʻāpana hana: glibenclamide - 5 mg, metformin hydrochloride - 500 mg. Kernel: sodium croscarmellose - 14.0 mg, povidone K 30 - 20,0 mg, cellulose microcrystalline - 54.0 mg, magnesium stearate - 7.0 mg. Ka: Opadry 31-F-22700 melemele - 12.0 mg: monactate lactose - 36,0%, hypromellose 15 cP - 28.0%, titanium dioxide - 20,42%, macrogol - 10,00%, kīwaha quinoline melemele - 3 , 00%, hao hāleʻa pōkole - 2,50%, ulaula pōpoki hao - 0,08%, wai maʻemaʻe - qs. ʻO keʻano
Kāleka 2.5 mg + 500 mg: nā kāpena biconvex i kālai ʻia, i uhi ʻia me ke kaʻi ʻoniʻoni o ke kala ʻulaʻula, me ke kahakaha o "2.5" ma ka ʻaoʻao hoʻokahi.
Dosis 5 mg + 500 mg: nā kāpena biconvex i kālai ʻia, i uhi ʻia me ka pale poni ʻoni, me kahi kālai "5" ma hoʻokahi ʻaoʻao. ʻO nā waiwai PharmacologicalʻO Glucovans ® kahi hui pūpū o ʻelua mau loiloi hypoglycemic waha o nā ʻano lāʻau lapaʻau like ʻole: metformin a me glibenclamide. Aia ʻo Metformin i ka hui o ka biguanides a hōʻemi i nā kiko o ka basal a me ka postprandial glucose i loko o ke koko koko. ʻAʻole ia e hoʻoikaika i ka metformin i ka huna ʻana i ka insulin a no laila ʻaʻole e kumu i ka hypoglycemia. He 3 mau hana i ka hana: hōʻemi i ka hana glucose glucose ma ka pale ʻana i ka glucoseoneogenesis a me ka glycogenolysis,hoʻonui i ka ʻike o ka poʻe ʻapopele o peripheral i insulin, ka ʻai a me ka hoʻohana ʻana i ka maʻi glucose e nā ʻālima ma o nā uaua,lohi i ka loaʻa ʻana o ka glucose i ka gastrointestinal tract.He hopena maikaʻi hoʻi ka lāʻau lapaʻau i ka hana lipid hoʻopili o ke koko, e hōʻemi i ka nui o ka kolamu, ka haʻahaʻa lipoproteins haʻahaʻa (LDL) a me ka triglycerides. He hana like ka metformin me ka glibenclamide hana like, akā hoʻopiha pū kekahi i ka hana hypoglycemic a kekahi. ʻO ka hui pūʻana o nā ʻaihue hypoglycemic ʻelua he hopena synergistic ma ka hoʻemi ʻana i ka glucose. Lapaʻau lāʻauʻO Glibenclamide. I ka wa e lawe waha ʻia, ʻike ʻia ʻana mai loko mai o ka wahi gastrointestinal ma mua o 95%. ʻO Glibenclamide, kahi ʻāpana o ka lāʻau Glucovans® i micronized. Pahu ʻia ka pae kiʻekiʻe o ka plasma i kahi mau hola 4, ʻo ka nui o ke kahe ana he 10 mau lita. ʻO ke kamaʻilio me nā protein plasma he 99%. ʻAno ua hoʻohālikelike maoli ia i loko o ke akea me ka hoʻokumu ʻana o ʻelua mau metabolites hana, a hoʻopiʻi ʻia e nā keiki (40%) a me ka bile (60%). ʻO ka pau hoʻopau hapa-ola mai 4 a 11 mau hola. Metformin ma hope o ka lawelawe waha, ua hoʻoiho ʻia mai ka gastrointestinal tract piha loa, ua hōʻea ka ʻike maka kiʻekiʻe i ka plasma i loko o 2.5 mau hola. Ma kahi o 20-30% o metformin e hoʻopili ʻia ma o ka gastrointestinal tract i loli ʻole. ʻO ka bioavailability kūpono mai 50 a 60%. Hoʻolaha koke ʻia ʻo Metformin i loko o nā pā, hoʻomaʻamaʻa ʻole ia i nā protein plasma. Hoʻomili ʻia ia i kahi pae palupalu loa a hoʻopā ʻia e nā keiki. ʻO ka wehe hapa hapa-ola he awelika o 6.5 mau hola. I ka hihia o ka hana renal impaired, hoʻomaʻemaʻe ka hoʻomaʻamaʻa ʻana o ka renal, i ka mea e hoʻomaʻemaʻe ana i ka hana o ka creatinine, ʻoiai e pau ka hapalua hapalua o ke ola, e alakaʻi ana i ka piʻi ʻana o ka metformin i ka plasma koko. ʻO ka hui pū ʻana o ka metformin a me glibenclamide ma ke ʻano ʻano like me ka bioavailability like me ka lawe ʻana i nā papa i loaʻa nā metformin a i ʻole glibenclamide i ka hoʻokaʻawale. ʻO ka bioavailability o ka metformin i hui pū me ka glibenclamide ʻaʻole i loaʻa i ka ʻai kai, me ka bioavailability o glibenclamide. Eia nō naʻe, piʻi ka nui o ka emi ʻana o ka glibenclamide me ka ʻaina meaʻai. Nā hōʻailona no ka hoʻohana ʻana:
Pākuʻi type 2 i nā pākeke:
me ka loaʻa ʻole o ka hoʻohana ʻana i nā meaʻai meaʻai, ka hoʻomaʻamaʻa kino a me ka monotherapy o mua me ka metformin a i ʻole ka hopena o ke olalona.e hoʻololi i ka lāʻau o mua i nā mea lapaʻau ʻelua (metformin a me derivative sulfonylurea) i nā mea maʻi me ka pae o ka glycemia pai a paʻa.Nā pālua:hypersensitivity no metformin, glibenclamide a me nā mea pōpū sulfonylurea ʻē aʻe, a me nā mea waiwai;maʻi diabetes type 1maʻi maʻamau ketoacidosis, maʻi kanesa, preca maʻi maʻi,hana ʻole a hana ʻole a paʻa ʻole kahi māka (hana i hana ʻia ma lalo o 60 ml / min),nā hopena ākea e hiki ke alakaʻi i kahi loli i ka hana o ka aʻalolo: kūʻai, maʻi hōʻeha, ke neʻe, ka neʻe ʻana a me nā ʻāpana o ka iodine e ʻike ʻia (e ʻike i nā "Kūlana Nūpepa")nā maʻi akamai a i ʻole ke hele ʻia e ka hui hypoxia: puʻuwai a i ʻole ka hanu, ka hala ʻana o ka myocardial infarction, pīhoihoi,pūpū hemaporphyriahapai, hapaicon conidance con miconazole,hoopukui nuihumuhinu maoli, huokuhiko make,lactic acidosis (me ka mōʻaukala),ka adherence i ka meaʻai haʻahaʻa-emi (emi iho ma mua o 1000 kaleka / lā),ʻAʻole ia e hoʻohana i ka lāʻau i loko o nā kānaka ma mua o 60 mau makahiki o ka mea e hana i ka hana kino kino, a pili pū me ka piʻi nui o ka hoʻomohala ʻana i ka acidact lactic i loko o lākou. Loaʻa i ka Glucovans ® ka lactose, no laila ʻaʻole i ʻōlelo ʻia ka hoʻohana ʻana i nā mea maʻi me nā maʻi hoʻoilina pānaʻi e pili ana me ka intolerance galactose, ka hemahema o ka lactase a i ʻole ka maʻi glucose-galactose malabsorption. Me ka mālama: febrile syndrome, adrenal insufficiency, hypofunction o ka pituitary anterior, maʻi thyroid me ka hoʻopaʻi ʻole uncompensated o kāna hana. Hoʻohana i ka wā hāpai a i ka wā o ka umauma
Hoʻopili ʻia ka hoʻohana ʻana o ka lāʻau i ka wā hāpai. Hoʻomaʻamaʻa ʻia ka mea maʻi i ka wā o ka mālama ʻana me Glucovans ® he mea pono ia e hōʻike i ke kauka e pili ana i ka hāpai ʻana a me ka hoʻomaka ʻana o ka hapai. Ke hoʻolālā nei i ka hapai, me ka mālama ʻana i ka wā hāpai i ka wā lawe i ka lāʻau Glucovans ®, pono e haʻalele ʻia ka lāʻau lapaʻau, a hoʻonoho ʻia ka mālama ʻana i ka insulin. Hoʻopili ke Glucovans ® i ka umauma umauma, no ka mea ʻaʻohe mea hōʻike i kona hiki ke hele i loko o ka waiū umauma. ʻ a me ke kākeleHoʻoholo ʻia ka nui o ka lāʻau e ke kauka ponoʻī no kēlā me kēia maʻi, e pili ana i ka pae o ka glycemia. ʻO ka papa lāʻau mua he 1 papa o ka lāʻau Glucovans ® 2.5 mg + 500 mg a i ʻole Glucovans ® 5 mg + 500 mg hoʻokahi i ka lā. No ka hōʻalo ʻana i ka hypoglycemia, ʻaʻole pono ka lāʻau o ka mua ma mua o ka nui o ka glibenclamide i kēlā me kēia lā (a i ʻole nā kaulike like o kekahi lāʻau lapaʻau sulfonylurea ma mua) a i ka metformin, inā ua hoʻohana ʻia lākou me ka lāʻau lapaʻau mua. Ke manaʻo ʻia nei e hoʻonui ʻia ka nui o nā hoʻomoʻa ma mua o 5 mg o glibenclamide + 500 mg o ka metformin i kēlā me kēia lā 2 mau pule aʻe paha e kiʻi i ka pono o ka glucose koko. ʻO ka hoʻoliʻi ʻana o ka hoʻokolohua hui ʻana me mua me ka metformin a me ka glibenclamide: ʻaʻole pono ʻo ka dosis mua i ka pākahi o kēlā me kēia lā o glibenclamide (a i ʻole ka hopena like o ka hoʻomākaukau ʻana o ka ʻaʻukui sulfonylurea) a me ka metformin i lawe ʻia ma mua. ʻO kēlā me kēia 2 a i hoʻokahi mau pule paha ma hope o ka hoʻomaka ʻana o ka hoʻōla, hoʻoponopono ʻia ke ʻano ma muli o ke ʻano o ka glycemia. ʻO ka nui loa o ka lā i helu ʻia he 4 mau papa o ka lāʻau Glucovans ® 5 mg + 500 mg a i ʻole 6 papa o ka lāʻau Glucovans ® 2,5 mg + 500 mg. Ka hoʻoponopono helu ʻana:
Kau ka dosimen dosage i ke kanaka hoʻokahi: No nā dosages o 2.5 mg + 500 mg a me 5 mg + 500 mg I ka lā hoʻokahi, i ke kakahiaka i ka wā o ka ʻaina kakahiaka, me ka koho ʻana o ka papa papa 1 i ka lā.ʻElua lā i hoʻokahi lā, kakahiaka a me ke ahiahi, me ke koho ʻana o 2 a 4 mau papa i ka lā.No nā dosage o ka 2.5 mg + 500 mg ʻEkolu lā i kahi lā, i ke kakahiaka, ahiahi a me ke ahiahi, me ke koho ʻana o 3, 5 a 6 mau papa i ka lā. No nā pākahi o 5 mg + 500 mg ʻEkolu lā i kahi lā, i ke kakahiaka, i ke ahiahi a i ke ahiahi, me ke koho ʻana o 3 papa i ka lā. Pono e lawe ʻia nā papa me nā meaʻai. Pono ka papa ʻaina e hui me ka papa me ka nui o ka haʻalulu ai ka nui o ka puʻukū e pale i ka loaʻa ʻana o ka hypoglycemia. ʻO nā maʻi maʻi
Koho ʻia ka nui o ka lāʻau ma muli o ke kūlana o ka hana nui. ʻAʻole pono ʻo ka pā mua ma mua o ka 1 papa lāʻau o ka lālau Glukovans ® 2,5 mg + 500 mg. Pono ʻia ka loiloi maʻamau o ka hana hoka. E na keiki
ʻAʻole ʻōlelo ʻia ʻo Glucovans ® no ka hoʻohana ʻana i nā keiki. Nā hopena hopenaHiki i nā hopena ʻokoʻa ke ola aʻe i ka wā o ka mālama ʻana me Glucovans ®. Ka piahia o ka hopena o ka aoao o ka laau i oleloia:
Hoʻohana pinepine: ≥ 1/10
Hoʻopiʻi pinepine: ≥ 1/100, ®. Hoʻoikaika ʻia ka hoʻōla ʻia ma hope o 48 mau hola, a aia wale nō ma hope o ka hana renal i loiloi ʻia a ʻike ʻia he ʻano maʻamau. Hola a kaʻili
No ka mea, ua ʻoki ʻia ka metformin e nā keiki, a ma ka manawa maʻamau, pono ia e hoʻoholo i ka clearance creatinine a me / a i ʻole nā mea serum creatinine: ma ka liʻiliʻi he hoʻokahi i hoʻokahi makahiki i nā mea maʻi me ka hana o ka māla maʻamau, a ma ka manawa 2 mau manawa o ka makahiki ma nā mea maʻi , aia pū i nā mea maʻi me ka wehe ʻana o creatinine i ka palena kiʻekiʻe o kahi maʻamau. Hoʻolaha ʻia ka mālama koʻikoʻi i nā hihia e loaʻa ʻole ai nā hana o ka pūpū, i ka laʻana, i nā mea maʻi maʻi, a i ʻole i ka hoʻomaka ʻana o ka lāʻau antihypertensive, ka hoʻohana ʻana i ka diuretics a i ʻole nā lāʻau o ka anti-inflammatory non-steroidal (NSAID). ʻO nā hana ʻē aʻe
Pono ka mea maʻi e hoʻomaopopo i ke kauka e pili ana i ke ʻano o kahi maʻi bronchopulmonary a i ʻole he maʻi ʻeha o nā genitourinary organitions. Hoʻokomo i ka hiki ke alakaʻi i kahi kaʻa a hana pū me nā mīkini
Pono e ʻike ʻia nā mea maʻi e pili ana i ka hopena o ka hypoglycemia a pono e mālama i nā hana akahele i ka wā e hoʻokele a hana ana me nā hana e koi nui ai ka nānā ʻana a me ka wikiwiki o ka hopena psychomotor. Mea hanaMERC SANTE SAAS
MERCK SANTE s.a.s. Wā i kū kānāwai:
37 rue Saint-Romain, 69379 LION SEDEX 08, Farani
37 rue Saint Romain, 69379 LYON CEDEX 08, Farani Pūnaewele:
Center de Production SEMOIS, 2 rue du Pressoire Ver, 45400 SEMOIS, Farani
Center de Production SEMOY, 2 rue du Pressoir Vert, 45400 SEMOY, Farani Pono e hoʻouna ʻia nā koi o nā mea kūʻai aku i:
ʻO ka Hale Kaʻina Hoʻokahi ʻo Nycomed
119048 Moscow, st. Usacheva, d. 2, p 1
Pūnaewele Pūnaewele: www.nycomed.ru ʻO ka ʻikepili ma ka ʻaoʻao ka mea i hōʻoia ʻia e ka mea hoʻokaumaha ʻo Vasilieva E.I. Nā manaʻo hoihoiPehea e koho ai i ka analog kūpono
I loko o ka pharmacology, hoʻokaʻawale pinepine nā lāʻau i nā ʻ synlelo a me nā kikowaena. Hoʻokomo ʻia i ke ʻano o nā like o nā ʻano like ʻole i ke ʻano he hopena therapeutic ma ke kino. Ke hoʻohālikelike nei nā analogs i nā lāʻau lapaʻau e pili ana i nā ʻano like like ʻole, akā no ka mālama ʻana i nā maʻi like. ʻO nā ʻokoʻa ma waena o nā maʻi a me nā maʻi bacterial
Hoʻopilikia ʻia nā maʻi maʻi e nā maʻi, nā maʻi, nā fungi a me ka protozoa. ʻO ke ʻano o nā maʻi i hoʻomake ʻia e nā maʻi a me nā maʻi like ʻole. Eia nō naʻe, e hoʻokaʻawale i ke kumu o ka maʻi ke koho ʻana i ka mālama kūpono e kōkua nui i ka hoʻokē ʻana i ka malaise a hōʻeha ʻole i ke keiki. ʻO nā maʻi āpau ke kumu o ke anuanu pinepine
ʻIke kekahi poʻe i kahi kūlana i kahi pinepine ke keiki a a lōʻihi no ka manawa anuanu. Lawe nā mākua iā ia i nā kauka, lawe i nā hoʻokolohua, lawe i nā lāʻau lapaʻau, a ma muli o ke ʻano, ua hoʻopaʻa inoa ʻia ke keiki me ke keiki e like me ka maʻi nui. ʻAʻole i ʻike ʻia nā kumu maoli o nā maʻi ʻeha pinepine. Urology: hana maʻi urethritis chlamydial
Loaʻa pinepine ʻia Chlamydial urethritis ma ka hana o kahi urologist. Hoʻokumu ʻia e ka intracellular parasite Chlamidia trachomatis, aia nō nā waiwai o nā huakini a me nā maʻi like, ua makemake pinepine i ka antibiotic therapy regimens no ka maʻi antibacterial. Hiki iā ia ke hana i ka mumū ʻole o ka maʻi o ka urethra i nā kāne a me nā wahine.
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