Kōkua ʻo Lozarel i kahi hoʻololi koko

Hoʻohana ka lāʻau Lozarel i ka cardiology, endocrinology a me nephrology. Loaʻa nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana i nā ʻōkuhi no ka hoʻohana kūpono o ka huahana, e pili ana i nā hiʻohiʻona hauka.

ʻO ke kumu o ka lāʻau lapaʻau ka losartan potassium ma kahi nui o 50 mg. ʻO nā mea hoʻohui'ē aʻe e pili ana i ka silic dioxide, magnesium stearate, lactose, starch. Loaʻa ka ʻōhumu i ka cellulose microcrystalline.

E hoʻokuʻu i ke ʻano

Hiki ke kūʻai ʻia ka lāʻau lapaʻau i nā papa, i kālai ʻia i loko o kahi pā kuhi 10 mau papa. I loko o hoʻokahi pākuʻi he 3 mau blus.

He papa keʻokeʻo ka papa papa (liʻiliʻi liʻiliʻi me ka melemele Tint) a me kahi ʻano pōʻai. Ma kekahi ʻaoʻao ka pilikia. ʻO ka ʻaoʻao o ka papa ma ke ʻano he kiʻi ʻoniʻoni.

Hoʻolaha ka hana

ʻO ka Angiotensin 2 he enzyme e, ma o ka paa ana i ka poʻe ʻokiʻī i loko o ka puʻuwai, nā ʻōpū a me nā kelepa adrenal, e hele ana i kahi kuʻikahi o ka lumen o kā lākou koko. Hoʻopilikia ʻia hoʻi i ka hoʻokuʻu ʻana o aldosterone. ʻO kēia mau hopena āpau e hoʻonui i ke kahe o ke koko.

Hoʻopili ʻo Losartan i ka hana o ka angiotensin 2, me kahi mea ʻole o ka hoʻokūkū ʻana. Ma muli o kēia, ua hiki aʻe nā loli like i ke kino:

• hōʻemi iki ka nui o ke kū'ē o ke vipula,
• emi ka nui o ka pae ald testosterone
• ua emi ke koko
• ka emi ke kahe o ka neʻe i ka pulmonary circulation.

Ke emi nei ke koko ma muli o ka hopena diuretic liʻiliʻi o ka lāʻau. Me ka komo pinepine ʻana, hoʻemi ʻia ka pilikia o ka naʻau o ka naʻau hypertrophy, hoʻomaikaʻi ʻia ke ahonui i ka poʻe me ka insufficiency myocardial e noho nei.

Loaʻa ka hopena kiʻekiʻe loa i 21 mau lā ma hope o ka hoʻomaka ʻana o ka hoʻokele. Loaʻa ka hopena antihypertensive ma loko o kahi lā.

Lākina ʻo Lozarel no ka cardiovascular, renal pathology a me ka hoʻopalehu o ka metabolism glucose. Hōʻike ʻia ka lāʻau lapaʻau no ka hoʻonui ʻana i ke kahe o ke koko ma muli o ka maʻi o lalo, a i ʻole hypertension o kahi etiology ʻike ʻole.

Hōʻike ʻia ka lāʻau lapaʻau no ka palaualelo o ka puʻuwai (hōʻemi i ka puʻuwai), ʻaʻole i kāpae ʻia e ka neʻe angiotensin-hoʻololi i ka inhibitor enzyme. Me ka hui pū ʻana o ke koko kiʻekiʻe, ʻoi aku ka wā kiʻekiʻe, haʻalele i ka hypertrophy ventricular a me nā mea ʻē aʻe, i hoʻohana ʻia e hōʻemi i ka make a me ka hopena o nā hōʻeha o ka vascular (hōʻeha ka naʻau, ke aʻalolo).

Hoʻohana ʻia ka lāʻau lapaʻau no nā hoʻopiʻi o ka diabetes mellitus type 2 - nephropathy, no ka mea e hōʻemi ana i ka hopena o ka holomua o ka maʻi.

Nā ʻōkuhi no ka hoʻohana

Lawe ʻia ʻo Losartan i hoʻokahi manawa i kēlā me kēia lā. Hoʻohana ʻia kahi nui o 50 mg e mālama i ka maʻi hypertension. Inā hoʻoholo ʻia nā hui ʻē aʻe o nā lāʻau antihypertensive, e hoʻomaka me ka hapalua o ka papa papaʻa. Inā pono, e hoʻonui i ka pona i 100 mg, hiki ke lawe ʻia i hoʻokahi manawa a i hoʻokaʻawale paha i 2 pūpē.

I ka hiki ʻana o ka puʻuwai naʻau, kuhikuhi ʻia ka liʻiliʻi ma kahi o 12,5 mg. I kēlā me kēia 7 mau lā ua pāpālua ʻia, hoʻonui pinepine ʻia i 50 mg. I kēia hihia, hoʻomaka lākou i ka portability o ka lāʻau lapaʻau. Me kahi hapalua hapalua (25 mg), inā he mea maʻi a pāpaʻi paha ka mea maʻi, aia nō ia ma hemodialysis.

E hoʻoponopono i ka proteinuria i ka maʻi diabetes, ua kuhikuhi ʻia ka lāʻau lapaʻau ma kahi o 50 mg / lā. ʻO ka dosis kiʻekiʻe loa i kēlā me kēia lā no 100 path.

ʻAʻole hilinaʻi ka ʻike ʻana i ka meaʻai a pono hoʻi i kēlā me kēia lā i ka manawa like.

Nā Hoʻohui

ʻAʻole ia i kuhikuhi ʻia ka pālāmele Losartan no kēlā mau hui o nā maʻi:

• me ka hua ʻole o ka ea o ke glucose a i ʻole galactose,
• hoʻonāukiuki glucose,
• galactosemia
• malalo o 18 makahiki
• hapai
• lāihana
• poʻe me ka hoʻomaloka ʻole i nā mea o ka lāʻau lapaʻau.

Pono ke nānā ʻana i ke ʻano o ka hoʻoneʻe ʻana no ka pēpē a i ʻole ka palupalu o ke aʻi, sten artery stenosis (2-ʻaoʻao a i ʻole unilateral me ke keiki hoʻokahi), a me ka hoʻokahe ʻana me ka nui o ke koko kahe o kēlā me kēia etiology. Me ka mālama aka, hoʻohana ʻia ʻo Lozarel no ka ʻike ʻole ʻana i nā electrolyte.

Nā hōʻailona no ka hoʻohana ʻana

ʻO ka lāʻau Lozarel e kauoha ʻia inā he:

1. Nā hōʻailona hōʻailona o ka hypertension.
2. ʻO ka hōʻemi o ka hopena o ka morbidity cardiovascular pili i ka poʻe e loaʻa ana i ka hypertension arterial a waiho ʻia nō hoʻi hypertrophy mai o ka ventricular, ka mea i hōʻike ʻia e ka hoʻohaʻahaʻa ʻana i loko o ka hui o ka maʻi cardiovascular, ʻeha a me ka myocardial infarction.
3. Hāʻawi i ka pale o ke keiki ma ka maʻi me nā maʻi diabetes type 2.
4. Ka pono e hoʻemi i ka proteinuria.
5. Hoʻopilikia ʻole ka puʻuwai hōʻeha me ka hoʻokele ʻole ʻana e ka ACE inhibitors.

Nā hopena hopena

ʻO ka ʻae ʻana i ka lāʻau e hiki ke hele pū me nā ʻano ʻino, kahi nāwaliwali a ʻaʻole pono e pau i ka hoʻopau ʻana i kāna ʻoihana. Hāʻawi ʻia lākou i ka papaʻaina.

ʻO nā hopena ʻinoʻino ʻaʻole ia e komo i loko o nā pūʻulu he gout.

Nā hōʻailona āpau

He mau ʻōhua like ʻole: he puʻuwai koke, ke kahaki nui i ke koko, ke ʻano ʻōpū puʻuwai ke hōʻeuʻeu.

Hoʻohana ka poʻe diuretics a me nā mea hōʻailona hōʻailona e hoʻoponopono i ke ʻano. ʻAʻohe hopena i ke kaʻina o ka hemodialysis, no ka mea ʻaʻole i lawe ʻia ka losartan mai nā nīpika koi i kēia ala.

Hoʻohui nūhou

Hoʻohui ʻia ka hoʻohana ʻana me ka diuretics mai ka paʻakai pākeleka, a me ka mākaukau e pili ana i ka potassium a me kāna paʻakai, e hoʻonui ai i ka pilikia o ka hyperkalemia. Hoʻonohonoho ʻia ka Hōʻemi Lozarel me nā paʻakai lithium, me ka piʻi ʻana o ka lithium i ke koko.

ʻO ka hoʻohana pūʻana o ka lāʻau lapaʻau me ka fluconazole a i ʻole rifampicin hiki ke hōʻemi i ka hoʻoliʻina o ka metabolite ikaika i loko o ka plasma. ʻO ka emi ʻana o ka hopena o ka lāʻau lapaʻau ke hele nei i ka wā e lawelawe pū ai me nā lāʻau anti-inflammatory non-steroidal i loko o kahi pākuʻi ʻoi aku ʻo 3 g.

ʻAʻole pili ʻo Losartan i kēlā mau lāʻau lapaʻau:

• warfarin
• kekiailu
• kāmakua
• fenobarbital,
• cimetidine
• erythromycin
• ketoconazole.

Hoʻonui ka lāʻau lapaʻau i nā hopena o nā β-blockers, diuretics a me nā lāʻau ʻē aʻe e hoʻemi i ke koko.

Nā ʻōlelo kikoʻī

ʻAʻole pā ka Losartan i ka neʻe ʻana, no laila ma hope o ka lawe ʻana hiki iā ʻoe ke alakaʻi i kahi kaʻa a hana pū me nā mīkini. I nā hihia kahi i hala aku ai kahi wai o ka lāʻau lapaʻau, inu nui ka papa ʻokoʻa ma hope e kū mai ka manawa. Inā mālama ka manawa e lawe i ka mahele hou aʻe, inu lākou iā ia ma ka papahele like he - 1 papa ʻaina (lawe ʻia ʻana ʻelua papa ʻelua).

Me ka hoʻohana mau ʻana o ka lāʻau lapaʻau, ʻike ʻia ke kiʻekiʻe o ka lā K. Inā hoʻohana ʻia ka lāʻau lapaʻau e kūʻē i nā kiʻi o nā nui o ka diuretics, aia kahi kūlana o ka hypotension. Hoʻonui ʻo Lozarel i ka pae o ka likaline a me ka urea i ka hihia o ka stenosis renal o kahi keiki hoʻokahi, a me ka bilateral stenosis o kēia mau moku.

Nā kuʻina: Presartan, Lozap, Cozaar, Blocktran, Lorista, Cardomin-Sanovel.

ʻO nā huahana māmā: Vazotens, Losartan.

Hoʻokumu ʻia i nā loiloi nui, hoʻomanawanui maikaʻi ʻo Lozarel me ka hoʻohana ʻana i ka manawa lōʻihi, ka kaomi o ka kaomi ma ka lā. He mea kaulana i waena o nā mea maʻi, a kuhikuhi pinepine ʻia e nā poʻe loea - nā lapaʻau, cardiologists, nā kauka ʻohana. ʻO kekahi o nā loiloi he mau hōʻailona o ka hōʻino maikaʻi.

Ke ola a me ka noho ʻana

Hiki i ka lāʻau lapaʻau ke hoʻohana i loko o 2 mau makahiki mai ka lā i hoʻopuka ai. Mālama ʻia ia i loko o kahi lumi o kona mahana ʻaʻole he 25 °.

Hoʻokomo ʻia ka lāʻau lapaʻau e lawe wale ma hope o ke ʻano o ka hoʻopaʻa ʻana, ka ʻoihana, ka hoʻokolohua instrumental, ka ʻike ʻana i nā ala e pili ana. Hiki i ke hoʻohana ponoʻana iā Lozarel i mea hoʻonāukiuki.

Nā hopena hopena

Ke mālama nei me ka Losarel, ʻaʻole hōʻike ʻia nā hopena o ka ʻaoʻao, a ʻaʻohe pono e hoʻōki i ka lāʻau.

I ka poʻe me nā pilikia o ka ʻōnaehana cardiovascular, ʻike ʻia nā maʻi like ʻole i kekahi manawa:

Me ka pale ʻole o ka gastrointestinal tract, nausea, ka ʻōpū o ka ʻōpū, constipation, hōʻeha o ka niho, ka hepatitis, gastritis, a me ka hoʻāʻo ʻana i ka hoʻāʻo. ʻAʻole paʻa kēia mau maʻi i ka poʻe ʻōpio.

Aia no ka dermatology, nā kūmole hemutaneus, ʻili maloʻo, a me ka nui o ka hihilū ʻana i hiki ʻole ke hele pinepine ʻia.

Ma ka māhele o ka ʻili, ka ʻaihue, kahi ʻū ma luna o ka ʻili, a puka mai nā pua.

Mai ka ʻaoʻao o ka ʻōnaehana musculoskeletal i nā ʻeha ma hope o nā wāwae, nā wāwae, ka umauma, ka ʻōpū, ka moʻo ʻana.

Me ka pale ʻole o ka ʻōnaehana o ka ʻōpū, pākē, ka uha o ka ihu, bronchitis, pharyngitis e kū nei.

I loko o ka urinary system - function renal impaired, urinary tract infection.

ʻLoe a me ke kākele

Pono e lawe i nā papa i loko o hoʻokahi lā i ka lā, me ke ʻano o ka ʻaina.

Me ka haina o ka hypertension ka mua a me ka mālama mau ʻana ma ka maʻamau ʻo 50 mg ka hoʻokahi i kēlā me kēia lā. Inā pono, hiki ke lawe ʻia i 100 mg.

I nā maʻi me ka pohō ʻole o ka naʻau e hoʻihoʻi i kahi dosis hoʻomaka o 12.5 mg, a laila e pālua i ka pule i kēlā me kēia pule, e lawe ana i 50 mg i kēlā me kēia lā.

Me ka maʻi papa maʻi 2, kahi mea i hui pū ʻia e proteinuria, ʻo ka dosis mua i ʻōlelo ʻia e 50 mg hoʻokahi i ka lā.

Ke hoʻokō nei i ka lapaʻau, ma muli o ke kahe o ke koko o ka mea maʻi, e ʻae ʻia e hoʻonui i kēlā me kēia lā i ka lā lapaʻau i 100 mg.

No ka hoʻemi i ka hopena o ka hoʻomohala ʻana i ka cardiovascular nā pilikia i ka poʻe me ka hypertension arterial, me ka hypertrophy hoʻokaʻawale hema, kahi maʻi mua o 50 mg hoʻokahi manawa i kahi lā i koho ʻia. I kēia hihia, hiki ke hoʻonui haʻahaʻa ʻia ka dosage i 100 mg i kēlā me kēia lā.

Nā kuleana a me nā kūlana e waiho ai

Store ma kahi wela ʻaʻole oi aku 25 ° C. E hoʻomau i ka lāʻau lapaʻau i ka hiki ʻole o nā keiki liʻiliʻi.

ʻO ka lā kau ʻO ka lāʻau lapaʻau he 2 mau makahiki.

Mai hoʻohana i ka lāʻau lapaʻau ma hope o ka lā pau.

ʻO ke kumukūʻai o ka lāʻau Lazorel e like me ka mea hana a me ka ʻoihana o nā lāʻau lapaʻau, i Lūkia ka awelika kumukūʻai mai 200 rubles.

I Ukraine ʻaʻole pālahalaha ka lāʻau a pili ana ma kahi o 200 UAH.

Inā pono, hiki iā ʻoe ke hoʻololi i "Lozarel" me kekahi o kēia mau lāʻau lapaʻau.

• Brozaar
• Blocktran
• Vero-Losartan
• ʻO nā ʻōwili
• Kālā-Sanovel
• Zisakar
• Keola
• Karzartan
• Lozap,
• Lakea
• ʻO Losartan A,
• Canon Losartan
• "Losartan potassium",
• Mahalaloa Richter,
• Nā Loli Makahiki,
• Losartan Teva
• "Lozartan-TAD",
• Kālehu
• Lorista
• Presartan
• Lotor
• "Hoʻopau."

Hoʻohana nui ʻia ka hoʻohana ʻana o nā analogues no ka mālama ʻana i nā hihia i loaʻa ai i ka mea maʻi i ko lākou hoʻomanawanui pilikino i nā ʻāpana o ka lāʻau. Eia naʻe, hiki i ke kauka ke kuhikuhi i kekahi lāʻau lapaʻau.

Hiki i nā loiloi o ka lāʻau lapaʻau ke loaʻa ma ka Pūnaewele, no ka laʻana, e kākau ana ʻo Anastasia: "ʻO koʻu maʻi maʻi nui e hoʻomau i ka ʻeha. ʻAʻole i liuliu, ua kū wau me nā mea hou o kēia maʻi. Ua hōʻike pū ʻia au me ka nephropathy. Ua kuhikuhi aku ke kauka i kahi helu nui o nā lāʻau like ʻole, e like pū me Lozarel. ʻO ia kēlā i kōkua i ka wikiwiki e hoʻihoʻi maikaʻi i ka hana maʻamau o nā keiki. Ua nalo aku ka huki ʻana.

Hiki i nā ʻike ʻē aʻe i ka hopena o kēia ʻatikala.

ʻIke ʻia ka lāʻau ʻo Lozarel he lāʻau lapaʻau ka hopena i ka mālama ʻana i ka maʻi hypertension a me ka hopena ʻole o ka naʻau. Hoʻonui ʻia ia i nā kukuna o nā analogues me nā papa like like ʻole, ʻaʻole i hāʻawi ʻia no nā pilikia o ka puʻukū a me nā pōpoki, a ma ka wā hāpai a ma lalo o nā makahiki 18. No ka hōʻalo ʻana i ka hopena o nā hopena ʻaoʻao, ʻoi aku ia e lawe i ka lāʻau lapaʻau e like me ka mea a ke kauka.

Pākuʻi helu

ʻO nā papa ʻoniʻoni kiʻi 12,5 mg, 25 mg, 50 mg, 75 mg, 100 mg

Hoʻokahi pū ʻia ka papa kiʻi ʻoniʻoni hoʻokahi

mea ikaika - losartan potassium 12,5 mg a i 25 mg a i 50 mg a i ʻole 75 mg a i ʻole 100 mg

nā mea waiwai: microcrystalline cellulose, povidone, sodium starch glycolate (type A), silicon dioxide colloidal anhydrous, magnesium stearate,

ke ʻano mea hana kiʻi ʻoniʻoni: opadray keʻokeʻo (OY-L-28900), lōpose lactose, hypromellose, titanium dioxide (E 171), macrogol, indigo carmine (E 132) alumini varnish (no ka laʻana 12.5 mg).

ʻO nā papa kiʻi ʻoniʻoni, ʻulaʻula, uliuli, i kahakaha me "1" ma hoʻokahi ʻaoʻao (no ka laʻu o 12,5 mg).

ʻO nā papa ʻoniʻoni ʻaʻoni kiʻi he oval, keʻokeʻo ma ke kala, me kahi notch ma kēlā me kēia ʻaoʻao a me ke kahakaha "2" ma kahi ʻaoʻao (no ka dosis he 25 mg).

ʻO nā papa ʻala kiʻi ʻoniʻoni ʻia he oval, keʻokeʻo ma ke kala, me kahi notch ma kēlā me kēia ʻaoʻao a me kahi kiʻi "3" i hoʻokahi ʻaoʻao (no kahi dosis o 50 mg).

ʻO nā peni, kālai ʻia ke kiʻi ʻoniʻoni, keʻokeʻo, keʻokeʻo, ʻelua ʻāpana ma kēlā me kēia ʻaoʻao a kahakaha ʻia "4" ma kēlā ʻaoʻao (no kahi laʻana o 75 mg).

ʻO nā peni, kālai ʻia ke kiʻi ʻoniʻoni, keʻokeʻo, keʻokeʻo, ʻekolu ʻai ma kēlā me kēia ʻaoʻao a kau ʻia "5" ma kēlā ʻaoʻao (no kahi laʻana o 100 mg).

Ka hana lāʻau lapaʻau

Ma hope o ka lawelawe waha, ua hoʻokomo maikaʻi ʻia ka losartan a hoʻomō i ka metabolism presystemic me ka hoʻokumu ʻia ʻana o ka metabolite hoʻoikaika o ka waikole carboxylic, a me nā metabolite keu ʻole. ʻO ka bioavailability o ka ʻōnaehana o ka losartan ma ka puka pā ma kahi he 33%. ʻO ka awelika o ka ʻike pinepine o ka losartan a me kāna metabolite ikaika e loaʻa ma hope o 1 hola a ma hope o nā hola 3-4, kēlā me kēia.

ʻO Losartan a me kāna metabolite kaha e ≥ 99% e paʻa ai i nā protein plasma, nui i ka albumin. ʻO ka nui o ka hoʻonuiʻana i ka losartan he 34 pā.

Ma kahi o 14% o ka make ʻana o losartan, i ka wā e hoʻokaʻawale loa ʻia a i ʻole ke lawe ʻia ʻana, e hoʻohuli ʻia i kāna metabolite ikaika. Ma hope o ka hoʻomoe ʻana a i ʻole komo ʻana o ka losartan potassium 14C-hōʻailona ʻia, ʻo ka radioactivity o ke kahe koko koko e hōʻike nui ʻia e ka losartan a me kāna metabolite hoʻoikaika. ʻO ka hoʻololi iki ʻana o losartan i kāna metabolite ikaika e nānā ʻia ma kahi o 1% o nā mea maʻi i nā haʻawina. Hoʻopili i nā metabolite hōʻola ikaika, kūkulu ʻia nō hoʻi nā metabolite inactive.

ʻO ka wehe i ka plasma o ka losartan a me kāna metabolite hoʻoikaika e like me 600 ml / minute a me 50 ml / minuke, kēlā. ʻO ka hoʻomaʻamaʻa kino ʻole o ka losartan a me kāna metabolite hoʻoikaika e like me 74 ml / mau minuke a me 26 ml / mau minuke, kēlā. I ka helu ʻana i ka losartan, ma kahi o 4% o ka nui o ka lae e kahuli ʻia ʻana i ka loko o ka urine a ma kahi o 6% o ka nui o ka ʻawaʻī i hoʻopio ʻia i loko o ka urine a me ke ʻano hoʻākina. ʻO ka pharmacokinetics o losartan a me kāna metabolite ikaika e linear i ka wā e hoʻokomo ai i ka potassium losartan i nā dosis a hiki i 200 mg.

Ma hope o ka lawelawe waha, ua ʻike ʻia ka ʻike o losartan a me kāna neʻe i ka hoʻoliʻi koko plasma, a ʻoi paha ka hapalua o ke ola he 2 mau hola a me 6-9 mau hola, kēlā.

ʻAʻole hōʻiliʻili ʻo Losartan a me kāna mau neʻe i ka nui o ka plasma koko inā hoʻohana ʻia kahi nui o 100 mg i hoʻokahi manawa i ka lā.

Hoʻokumu ʻia ka Losartan a me kāna ʻano neʻe i ka cile i ka hua bile a me ka maʻi pā. Ma hope o ka lawelawe waha, ma kahi o 35% a me 43% ka mea i hoʻopuka ʻia i loko o ka pā i, a me 58% a me 50% me nā feces, pakahi.

Pharmacokinetics i loko o nā hui hoʻomanawanui pilikino

I ka poʻe maʻi nā maʻi me ka hypertension arterial, ʻo ka ʻike ʻana o ka losartan a me kāna metabolite hoʻoikaika i ka plasma koko, ʻaʻole i ʻokoʻa loa ka poʻe i loaʻa i nā poʻe ʻōpio me nā hypertension arterial.

I ka poʻe maʻi me ka wahine hypertension arterial, ʻo ka nui o ka losartan i loko o ke koko he ʻelua mau manawa iʻoi aku ma mua o nā mea maʻi me nā kāne arterial hypertension, aʻo nā pae o ka metabolite ikaika i ka plasma koko, ʻaʻole i ʻokoʻa i ke kāne a me nā wahine.

I nā mea maʻi me ka cirrhosis hōʻemi iki o ka palupaleka, nā pae o losartan a me kāna metabolite hoʻoikaika i ka plasma koko ma hope o ka lawelawe ʻana i ka waha he 5 a me 1,7 mau manawa, kēlā, e kiʻekiʻe aʻe i nā maʻi kāne ʻōpio.

I nā maʻi me ka cleinine clearance ma luna o 10 ml / min, ʻaʻohe loli o ka plasma o ka losartan. Hoʻohālikelike ʻia me nā mea maʻi me ka hana maʻamau maʻamau, i nā mea maʻi ma ka hemodialysis, kahi AUC (wahi ma lalo o ka kukuhi-manawa o ka manawa) no ka losartan e like me ka nui o 2 mau manawa.

I nā mea maʻi me ka hiki ʻole o ka pilikia a i ʻole nā ​​mea maʻi ma ka hemodialysis, he like nā mea no ka plasma.

ʻAʻole kahi lawehala a Losartan a me kāna metabolite hoʻoikaika e ka hemodialysis.

ʻO Losartan kahi syntagon ala II nā ʻāpana ʻāmaʻomaʻo (type type AT1) no ka hoʻohana waha. ʻO Angiotensin II - kahi vasoconstrictor ikaika - he hana ikaika o ka pūnaha renin-angiotensin a ʻo kekahi o nā mea nui i ka pathophysiology o ka maʻi hypertension arterial. Hoʻopili ʻo Angiotensin II i nā ʻĀkī AT1, aia i ʻike ʻia i loko o nā palima he nui (no ka laʻana, ma nā kikoʻī ma waena o nā kīʻaha koko, nā kelepaʻi adrenal, nā ʻōpū a me ka puʻuwai), e hoʻoholo ana i kekahi o nā hopena olakino koʻikoʻi, me ka vasoconstriction a me ka hoʻokuʻu ʻana o aldosterone.

Hoʻoulu ʻia hoʻi ka Angiotensin II i ka hoʻomaikaʻi ʻana o nā pūpū māla maikaʻi.

Hoʻopili paʻa ʻo Losartan i nā ʻĀkeke ʻae. ʻO Losartan a me kāna metabolite hoʻonaninani hoʻōla - nā carboxylic acid (E-3174) - ālai i nā hopena āpau o ka physiologically nui o ka angiotensin II, me ke ʻano o ke kumu a me ke ala o ka synthesis.

ʻAʻohe o ka hopena antiagonistic o Losartan a ke kāohi ʻole nei i nā ʻae like ʻana i nā hāmeʻa hāmeʻa a i ʻole nā ​​kaona ʻoi i pili i ka hoʻoponopono ʻana o ka ʻōnaehana cardiovascular. Eia kekahi, ʻaʻole e pale ka losartan i ka ACE (kininase II), kahi huina e hoʻoikaika ai i ka wāwahi o ka bradykinin. I ka hopena, ʻaʻohe piʻi i ka manawa o ka hopena i hoʻopulu ʻia e bradykinin.

I ka wā o ka hoʻohana ʻana i ka lāʻau Lozarel e hoʻopau nei i ka hopena o ka hopena i ka hopena o ka angiotensin II i ka hana ʻana i ka mea huna huna i mea e hoʻonui ai i ka hana renin plasma (ARP). ʻO ke hoʻonui ʻana i ia hana e alakaʻi ai i ka hoʻonui ʻana i ke kiʻekiʻe o ka angiotensin II i loko o ke koko koko. ʻOiai ke hoʻonui nei, ka hana antihypertensive a me ka hoʻohaʻahaʻa ʻana i ka paʻa o ka aldosterone i loko o ke kaila plasma he mau, e hōʻike ana i kahi blockade maikaʻi o nā receptors II. Ma hope o ka hoʻokuʻu ʻana i ka losartan, ka hana plasma i hana ʻia a me nā angiotensin II pae no nā lā 3 e hoʻi i ka waihona.

ʻO nā losartan a me kāna metabolite koʻikoʻi he pilina kiʻekiʻe loa no nā mea hoʻokae AT1 ma mua o ka AT2. ʻO ka metabolite ka mea nui he 10 a 40 mau manawa e ʻoi aku ka ikaika ma mua o ka losartan (i ka manawa i hoʻohuli ʻia i ka nui).

ʻO kahi helu hoʻokahi o losartan i nā mea maʻi me ka maʻi haʻahaʻa o ka hypertension arterial e hōʻike ana i kahi nui o ka statistically nui i loko o ke systolic a me ka diastolic blood pressure. Hoʻoulu ka hopena ʻoi loa o ka losartan i nā hola 5-6 ma hope o ka hoʻokele ʻana, hoʻomau ka hopena therapeutic i 24 mau hola, no laila ua lawa ia e lawe i hoʻokahi manawa i ka lā.

Pharmacodynamics a me ka pharmacokinetics

ʻO Losartan kahi ʻano ākea receptor angiotensin II (type AT1) antagonist.

• Hoʻopili i nā ʻae AT1, nā mea i pili i nā palahalaha mānoʻi o nā kīʻaha koko, nā puʻuwai, nā pūpū, a me nā kelepa adrenal hoʻi.
• aia ka hopena vasoconstrictive, hoʻokuʻu i ke aldosterone,
• holoholo i ka angiotensin II,
• ʻaʻole i kōkua i ka kaomi ʻana o ka kinase II - ka huila o ka mea e luku ai ka bradykinin.

"Lozarel," i hōʻike ʻia e ka ho'ākāka ʻana o ka lāʻau lapaʻau, hoʻomaka koke e hana koke. Ma hope o hoʻokahi hola, ua hōʻea i ka neʻe ʻana o ka lazortan, ʻoi aku ka lōʻihi o ka manawa no 24 mau hola. ʻO kaʻoiaʻiʻo, ua emi ka neʻe i ka 6 mau hola ma hope o ka lawe i ka paila. Hoʻomaopopo ka hopena antihypertensive maikaʻi ma hope o 3-6 pule. Hoʻopili ʻo Losartan i kahi hapa albumin e 99%, hoʻopili ʻia e nā pōpoki a me nā mea pono o loko.

Ke keu

Nā hōʻailona: ʻAʻole i hōʻike ʻia nā hihia o ka lāʻau overdose. ʻO nā hōʻailona e pili ana i ka overdose o ka hypotension arterial, tachycardia, bradycardia hiki ke hele mai no ka hoʻouluʻana parasympathetic (vagal).

Hoʻomaʻamaʻa: Inā hele mai ka hōʻailona hypotension, pono e hāʻawi ʻia ke kākoʻo kākoʻo. Pili ka hopena i ka lōʻihi o ka manawa i hala ma hope o ka lawe ʻana iā Lozarel, a me ke ʻano a me ka hōʻino o nā hōʻailona. ʻO nā mea nui e pono e hāʻawi ʻia i ka hoʻomau ʻana o ka ʻōnaehana cardiovascular. Ke kumu o ka carbon carbon. Ka nānā ʻana i nā hana nui. He waiwai ʻole ka hemodialysis, no ka mea ʻaʻole a losartan a me kāna metabolite kūlohelohe i waho i ka wā hemodialysis.

Lapaʻau lāʻau

Ma hope o ka lawelawe waha, ua maikaʻi maikaʻi ka losartan mai ka gastrointestinal tract. Ma ka papa mua e pili ana i ka ate, ka mea e hoʻomōhala i ka metabolism e ka carboxylation me ka komo ʻana o ka isoenzyme CYP2C9 a me ke ʻano o ka metabolite ikaika. ʻO ka bioavailability o ka ʻōnaehana o losartan e like me 33%. Ka hoʻokūkū nui (C_max) ʻo ka mea ikaika o Lozarel i loko o nā serum koko ma hope o ka hola 1, a me kāna metabolite ikaika ma hope o nā hola 3-4. ʻAʻole pili ke komo i ka meaʻai ʻai i ka bioavailability o losartan. I kahi wai a hiki i ka 200 mg, mālama ka losartan i ka pharmacokinetics linear.

Hoʻopili i nā protein plasma koko (ma mua me ka albumin) - ʻoi aku ma mua o 99%.

V_{e d} (ka laulā o ka nui) 34 mau lita.

Aneane ʻaʻole ia e komo i kahi papa koko-lolo.

Aia a 14% o ka waha waha o losartan e hoʻohuli i ka metabolite ikaika.

ʻO ka wehe i ka plasma o ka losartan he 600 ml / min, ʻo ka wehe ʻana i ka renal he 74 ml / min, ʻo kāna metabolite hoʻonaninani he 50 ml / min a me 26 ml / min, ma kēlā.

Ma kahi o 4% e kaomi ʻia ma o ka pēpē i loli ʻole, a hiki i ka 6% o ka loaʻa i loko o ke ʻano o ka metabolite hoʻoikaika. Hoʻopau ʻia ke koena ma o ka ʻili.

ʻO ka hapalua o ka ola hope o kahi mea mālama mau no kahi 2 mau hola, kāna metabolite hoʻoikaika - a hiki i ka 9 hola.

E kūʻē i ke ʻano o ka hoʻohana ʻana iā Lozarel i loko o kēlā me kēia lā o 100 mg, ʻike ʻia kahi liʻiliʻi o losartan a me kāna hana metabolite i ka lolo koko.

Me ka hōʻeha a me ka hoʻohaʻahaʻa maʻalahi o ka cirrhosis ate waihue, ʻo ka piʻi ʻana o ka losartan e hoʻonui i ka manawa 5, a me ka metabolite hoʻoikaika - 1,7 mau manawa, hoʻohālikelike ʻia me nā mea maʻi me kēia palaka

ʻO ka ʻike o ke losartan i ka plasma koko i loko o nā mea maʻi me ka cleince clearance (CC) ma luna o 10 ml / min ka like ia i kēlā me nā mea maʻi me ka hana o ka renal maʻamau. Me ka CC mau emi ma mua o 10 ml / min, ka waiwai o ka nui o ke koina o ka lāʻau (AUC) i loko o ke koko koko e piʻi e pili ana i 2 mau manawa.

Me ka hemodialysis, ʻaʻole i haʻalele ʻia ka losartan a me kāna metabolite ikaika mai ke kino.

I nā kāne me ka hypertension arterial i ka wā ʻelemakule, ʻaʻole i ʻokoʻa maoli ka nui o ka hōʻemi o ka hōʻemi ʻana i ka plasma koko i nā ʻāpana like ʻole i nā ʻōpio.

Me ka hypertension arterial i loko o nā wahine, ʻo ka neʻe ʻana o ka plasma o losartan he 2 mau manawa kiʻekiʻe ma mua o nā kāne. Hoʻohālike ka ʻike o ka metabolite ikaika. ʻO kahiʻokoʻa pharmacokinetic i hōʻike ʻia, ʻaʻohe hōʻailona koʻikoʻi o ka maʻi.

Pehea e lawe ai a ma ke kumu a ke kaomi, ka nui

"Lozarel", ka ʻōlelo maʻa no ke hoʻohana e wehewehe i ka pauku dosage maikaʻi loa no nā maʻi like ʻole, e hoʻohana ʻia no kahi meaʻai. Ua inu ka papa i ka manawa like i ka manawa a i ka lā ma ka kaha i hōʻike ʻia e ke kauka.

Me ka hypertension (piʻi ke koko i luna ma luna o 140/90 mm Hg), lawe ʻia ka lāʻau lapaʻau ma 50 mg i kēlā me kēia lā. Wahi a nā hōʻailona, ​​hoʻonui ka nui o ka dosage i ke kiʻekiʻe o 100 mg. Me ka hoʻokaʻawaleʻana BCC, hoʻomaka ka mālamaʻana i ka hypertension me 25 mg. I kēlā me ke koko i hōʻike ʻia ka lāʻau lapaʻau, i kēlā me kēia kūlana ke hoʻoholo ke kauka.

Hana ʻia ka naʻau hōʻokoʻa e like me kahi pākahi hana. Hoʻomaka ka Therapy ma ka 12.5 mg o ka lāʻau lapaʻau i kēlā me kēia lā. Ma kēlā me kēia pule, e pāpālua ʻia ka nui: 25, 50, 100 mg. Inā pono, hiki iā ʻoe ke loaʻa he 150 mg o "Lozarel" i kēlā me kēia lā.

Me ka nephropathy pū kekahi me ka lolo II type, lawe nā mea maʻi i ka 50 mg o ka lāʻau lapaʻau i kēlā lā. Hiki ke hoʻonui i ka momona i ke kiʻekiʻe o 100 mg. He kūpono kēia hana no ka poʻe maʻi me ka hypertrophy left ventricular.

Nui! No nā poʻe maʻi ʻelemakule (ma mua o 75 iho mau makahiki he nui), nā mea maʻi me nā maʻi like ʻole o ke ake a i ʻole nā ​​ʻōpū, hoʻoponopono ʻia ka hoʻoponopono ʻia e ke kauka ma ke ʻano o ka hōʻemi ʻana i kēlā me kēia lā i kēlā me kēia lā.

Hoʻohui

ʻO ka hui pū ʻana o "Lozarel" me NSAIDs hiki ke alakaʻi i ka hiki ʻole o nā keiki. Hoʻemi nui ka hopena o nā lāʻau antihypertensive.

ʻO ka hui pū me nā mea hoʻohana lithium e loaʻa ana ka hoʻonui i ka lithium plasma.

Hiki i ka diuretics pākakai me ka "Lozarel" hiki ke hoʻonāukiuki i ka hopena o hyperkalemia.

Hoʻonui kēia lāʻau lāʻau i ka hopena ma ke kino o nā lāʻau antihypertensive. I ke kuhikuhi ʻana iā "Lozarel" a me nā pale o ATP, pono ia nānā pinepine i ke ʻano o nā pūpū, ʻo ka piʻi pinepine ʻana o ka hopena pili hewa.

Hiki ke "hoʻololi iā" Lozarel "me kahi mea lapaʻau e like me nā hopena like. Nā Kūlana:

Heʻokoʻa nā kumukūʻai ma nā kumukūʻai a me nā mea hana. Akā ʻaʻole ʻoe e hoʻololi kūʻokoʻa i kahi "Lozarel" i kuhikuhi ʻia e kāu kauka no ka lāʻau ʻē. Pono ke koho kuikawa e kekahi loea e loiloi i ke kūlana olakino o ka mea maʻi a me ka pae o ka hana o ka lāʻau lapaʻau i kēlā me kēia hihia.

Lozarel, nā ʻōlelo e pili ana i ka hoʻohana ʻana: ke ʻano a me ka helu ʻana

Lawe ʻia nā papa Lozarel ma ke alo, me he mea lā o ka ʻaina.

• hypertension arterial: hoʻomaka a me ka mālama mālama ʻia - 50 mg hoʻokahi ma ka lā. Ma ka lilo ʻole o kahi hopena lapaʻau e pono ai i kekahi mau mea maʻi, hiki ke hoʻonui ʻia kahi nui o ka piʻi ʻana a hiki i ka 100 mg, ma kēia hihia, lawe ʻia nā papa i 1 a i 2 mau manawa paha i ka lā. Me ka ʻoihana hoʻohālikelike me nā hilo kiʻekiʻe o nā diuretics, pono ke hoʻomaka ʻia ka hoʻohana ʻana iā Lozarel me 25 mg (1/2 papa) hoʻokahi manawa i ka lā,
• ka paʻa ʻana o ka puʻuwai maʻi: ʻo ke kau mua ʻana he 12.5 mg (1/4 papa) 1 ka manawa i kēlā me kēia lā, ʻo kēlā me kēia 7 mau lā e hoʻonui i ke kau manawa 2 mau, hoʻonui pinepine ʻia i 50 mg i kēlā me kēia lā, i hāʻawi ʻia ke ahonui i ka lāʻau.
• type 2 diabetes mellitus me ka proteinuria (e hoʻemi i ka pilikia o ka hoʻomohala ʻana i ka hypercreatininemia a me ka proteinuria): ʻo ka lāʻau mua ma mua o 50 mg hoʻokahi i ka lā. Wahi a nā palena o ke kahe o ke koko i ka wā e hoʻōla ai, hiki ke hoʻonui ʻia i loko ka 100 mg i 1 a i 2 paha mau dosis,
• hypertension arterial i loko o nā mea maʻi me ka hypertrophy ventricular hema (hoʻohaʻahaʻa i ka pilikia o ka hoʻomohala ʻana i nā hoʻopiʻi cardiovascular a me ka make): ka mua o ka pākēneka (50 mg hoʻokahi) i ka lā, inā pono, hiki ke hoʻonui ʻia i 100 mg.

No ka poʻe maʻi me ka hana renal impaired (CC ma mua o 20 ml / min), he mōʻaukala o ka maʻi ate, ka huhū, ma mua o 75 mau makahiki o a i ka wā e hele ana i ka dialysis, ʻo ka mua o ka lā ma mua o Lozarel e kuhikuhi i ka nui o 25 mg (1/2 papa).

Me ka hana pūnāwai paʻa ʻole

Pono e mālama ʻia i ka mālama ʻana i nā mea maʻi me ka hiki ʻole o ka pilikia ʻole, kahi o ka stenosis arela i loko o ka bilateral, a me ka stenosis o ke kino lāʻau hoʻokahi.

Manaʻo ʻia no ka hana renal impaired (CC ma mua o 20 ml / mau min): i mua ka hoʻomakaʻana - 25 mg (1/2 papa) 1 manawa i kēlā me kēia lā.

Hoike ʻia ma Lozarel

He kūpono nā loiloi e pili ana i nā maʻi maʻi Lozarel a me nā loea. Hoʻomaopopo nā kauka i ka lāʻau lapaʻau, ma kahi o nā hana antihypertensive, he hopena diuretic hou. Hoʻomaha ʻo Lozarel i ka hoʻouka a pale i ka hoʻomaka a me ka hoʻomohala ʻana i ka hypocrophy myocardial. I ka hiki ʻole o ka puʻuwai naʻau, hiki i ka hiki ke kū i ka hana kino e hoʻonui.

I ka poʻe maʻi me ka maʻi mellitus a me nephropathy, e lawe ana iā Lozarel e hōʻoia i ka lawe ʻana o ka edema.