Rosart: nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana, nā hōʻike ʻana, nā loiloi a me nā analog

Ua hoʻohana maikaʻi kā mākou poʻe heluhelu iā Aterol e hoʻohaʻahaʻa i ka cholesterol. Ke ʻike nei i ka kaulana o kēia huahana, ua hoʻoholo mākou e hāʻawi iā i kou makemake.

Rosart - kahi lāʻau lapaʻau e pili ana i nā stins, i hoʻohana ʻia e hoʻohaʻahaʻa i ka cholesterol koko. ʻO ka lāʻau Rosart he mea hoʻomake mau i nā rosuvastatin. Loaʻa ka lāʻau lapaʻau i ke ʻano o nā papa 5, 10, 20 a me 40 mg ma ke ʻano o ka Actavis Group ma Iceland. Hoʻohana nui ka Rosart e mālama i ka hypercholisterinemia.

• Nā hōʻailona no ka hoʻohanaʻana i ka lāʻau lapaʻau
• Hoʻohana maikaʻi a me ka statin
• Hoʻoholo nā Rosart i koho ʻia
• Āhea hiki ʻole iaʻu e hoʻohana iā Rosart?
• Hāpai a hānai i kahi pēpē
• E hoʻohana me Rosart me ka akahele
• Nā hopena maikaʻiʻole
• Nā hiʻohiʻona o ka lāʻau

Loaʻa iā Rosart nā waiwai lapaʻau e pili ana:

• hoʻohaʻahaʻa i ka kolamu - lipoproteins haʻahaʻa haʻahaʻa,
• ka hoʻohaʻahaʻa ʻana i ke kiʻekiʻe o ka cholesterol A - nā lipoproteins haʻahaʻa loa.
• hoʻohaʻahaʻa i ka kolamu nui a me ka triglycerides i ke koko,
• hoʻohaʻahaʻa i ka kolamu - kiʻekiʻe nā liproteins,
• hoʻohaʻahaʻa i nā ʻano like ʻole o ka cholesterol - kiʻekiʻe a me nā lipoproteins haʻahaʻa haʻahaʻa,
• pili i ka pae o alipoproteins A a me B.

Hoʻokumu ka hopena hypolipidemic o Rosart i ka dosage i hoʻohana ʻia. Ma hope o ka hoʻomaka ʻana o ka lāʻau Rosart, ʻike ʻia ka hopena therapeutic ma hope o hoʻokahi pule, ma hope oʻelua pule he hiki i ka 90%, a ma hope o ʻehā mau pule o ka hoʻohana ʻana i ka hopena pharmacological nui loa e hoʻokō a noho mau ma kēia pae. Hoʻomoʻa ka lāʻau i ka hana pale, hoʻokaʻawale i ke ake a hoʻōla ʻia i kahi nui aʻe ma o nā ʻāpana, a i ʻole ka liʻiliʻi i nā keiki kau.

He aha ka mea e kōkua ai iā Rosart?

Rosart, kiʻi o nā papa

ʻO nā ʻōkuhi no ka hoʻohana ʻana i ka lāʻau lapaʻau penei:

• ʻO ka hypercholesterolemia mua a i ʻole ka hoʻohui hyperlipoproteinemia,
• hoʻoilina hypercholesterolemia, ʻaʻole hiki ke mālama ʻia i ka lāʻau ʻana i nā meaʻai a me nā ʻano lāʻau ʻē aʻe.
• mahuahua o ka triglycerides,
• i mea e hoʻolōʻihi i ka holomua o ka atherosclerosis,
• e like me ka pale mua ʻana o nā hoʻopiʻi maʻamau o nā maʻi cardiovascular (stroke, hōʻeha ka naʻau, ischemia).

E hoʻokuʻu i ke ʻano a me ka ʻano

Loaʻa ka Rosart i ke ʻano o nā papa kiʻi ʻoniʻoni: biconvex, ma kekahi ʻaoʻao i kahakaha ʻia ʻo "ST 1" ma nā papa ākea keʻokeʻo, "ST 2" a me "ST 3" ma nā papa ʻala a pink, "ST 4" ma mahele ʻula a pink (i blisters: 7 pcs., i kā i ka pahu pepa 4 blisters, 10 pcs., i loko o kahi pahu kālele 3 a i ʻole 9 blisters, 14 pcs., i kahi pōpō kāleka 2 a i 6 blisters).

Pākaukau 1 papa:

• mea kūlohelohe: rosuvastatin calcium - 5.21 mg, 10.42 mg, 20.84 mg a i 41.68 mg, he kūlike kēia me ka waihona o 5 mg, 10 mg, 20 mg a 40 mg o rosuvastatin, ma ia mea,
• ʻO nā mea kōkua: lactose monohydrate, microcrystalline cellulose (type 102), calcium hydrogen phosphate dihydrate, crospovidone (type A), magnesium stearate,
• Ke ʻano mea hana kiʻi ʻoniʻoni: nā keʻokeʻo keʻokeʻo - Opadry keʻokeʻo II 33G28435 (titanium dioxide, hypromellose-2910, monohidate lactose, triacetin, macrogol-3350), nā papa māpuka - Opadray pink II 33G240007 (titanium dioxide, hypromellose-2910, monactate lactose, triacetin , macrogol-3350, ʻohi i ka carmine red).

Nā ʻōkuhi no ka hoʻohana ʻana iā Rosart, dosage

Hiki ke lawe ʻia ka Rosart i kēlā me kēia manawa o ka lā, ʻaʻohe mea o ka meaʻai. He mea nui ia i ka mea maʻi i ka wā o ka mālamaʻana e pili i kahi meaʻaiʻaiʻai ikaika, ʻo keʻano o ia ka koina i hōʻole ʻia i nā mea momona.

Ua koho paʻa ʻia ka nui o kēia hewa ma ke ʻano like ʻole e like me nā ʻōnaehana o ka laboratorium o ka pae kolamu, ka loaʻa ʻana o nā ala maʻi cardiovascular a me nā maʻi gastrointestinal.

I ka hoʻomakaʻana o nā papa therapeutic, ʻo ka nui loa i ka lā dactage maʻamau he 5 a 10 mg. ʻO ka loiloi o ka mālama ʻia e hana ʻia i ʻehā mau pule ma hope: inā ʻaʻole i maʻamau ka pae o ka "maikaʻi", a laila hoʻonui ka nui o ka lāʻau i 20 mg, a inā pono, i 40 mg.

Inā lawe ka mea maʻi i ka nui o ka lae ʻia, a laila pono ke mālama ʻia i ka lāʻau lapaʻau maʻamau, no ka mea aia nō ke kūlana kiʻekiʻe o ka ulu ʻana i nā hopena ʻino.

ʻO nā ʻōlelo e hoʻohana ai iā Rosart e huki maoli ana i ka launa pū me nā lāʻau lapaʻau ʻē aʻe.

1. Inā lawe ka mea maʻi i ka immunosuppressive agent Cyclosporine, a laila ʻoi aku ka nui o ka mea i manaʻo ʻia o Rosart ma 5 mg.

2. ʻO ka lāʻau Hemofibrozil ka hopena lapaʻau like like me Rosar, no laila pono e lawe ʻia nā lāʻau ʻelua i ka liʻiliʻi a liʻiliʻi paha.

3. ʻO nā mea hoʻomoʻo protote (nā lāʻau antiretroviral i kauoha ʻia no ka maʻi immunodeficiency, nā lāʻau lapaʻau - Agenerase, Crixivan, Virasept, Aptivus) i pāpā aku i ka enzyme e pili ana i ka wāwahi i ka polyproteins. No laila, inā lawe ka mea maʻi iā Rosart me kēia lapaʻau, a laila e hoʻonui ka hoʻonui ʻana o ka hopena i ʻekolu mau manawa. I kēia hihia, ʻo ka nui o ka nui o ka māhuhu o ka lipid-hoʻemi haʻahaʻa e pono e ʻoi aku ma mua o 10 mg.

Pono e holoi ʻia ka lāʻau lapaʻau me ka nui o ka wai, ʻaʻole ʻōlelo ʻia nā papa ʻalā.

ʻO nā maʻi ākea a me ke kauā

I loko o kaʻeha kino o ka maʻi, maʻi o ka puʻuwai a me nā dystrophy hoʻohe, ʻaʻole i kuhikuhi ʻia nā papa. ʻAʻole ʻōlelo ʻia ʻo Rosart i nā wahine e hoʻolālā nei i kahi hāpai.

ʻO nā maʻi ʻē aʻe - ʻo ka wā holoʻokoʻa o ka hapai, lactation (ka umauma) a me nā keiki ma lalo o 18 makahiki o kona mau makahiki.

ʻAʻole i kuhikuhi ʻia ka nui o ka nui loa inā ua maʻi ka mea maʻi i ka hypothyroidism (nele i nā hormone thyroid) a hōʻino wale i nā mea inu ʻawaʻawa (ma kēia hihia, ua ʻōlelo ʻia kahi palupaʻa hāmole a i ʻole ke kuhikuhi ʻana i ka lāʻau i kekahi). Ua kuhikuhi ʻia nā pākaukau me ka mālama ʻana i nā maʻi nā mea a kahi o nā hoahānau e hōʻeha i ka ʻehaʻeha o ka dystrophic. No ka poʻe o ka lāhui Mongoloid, ua kuhikuhi ʻia ka lāʻau lapaʻau me ka liʻiliʻi ʻokoʻa loa.

I kekahi mau hihia, lawe i ka lāʻau lapaʻau hiki i ke ʻano ke hoʻopalike o kēia ʻaoʻao:

• nā hōʻike ʻakaʻala i ke ʻano o ka ʻulaʻula o ka ʻili, ka ʻōpala liʻiliʻi, ka haki,
• ʻeha, hōʻeha, hōʻeha ka naʻau,
• ka hana o ka hana endocrine, i hōʻike ʻia i ka hoʻomohala ʻana o ka maʻi type 1
• wikiwiki a luhi
• māhuahua i ke koko, palpitations.

ʻAʻole kuhikuhi ʻia ka mea maʻi e hoʻoponopono kūʻokoʻa i ke ʻano i luna. Inā ʻaʻole, hiki i nā ʻōmole overdose ke ulu nei:

• holo, ke kahakaha, he pale,
• ʻeha ka ʻōpū
• ka ʻili o ka ʻili, pau ka ʻike,
• ku e pili ana i ka hanu ana a me ka puuwai naau.

Inā kū kēia mau ʻano, pono e hoʻoikaika nui, a ma mua o ka hōʻea ʻana o nā kauka, e kaʻa i ka ʻōpū o ka mea maʻi.

Lapaʻau lāʻau

ʻO Rosart kahi lāʻau lapaʻau mai ka hui o statins me nā hana lipid-hoʻohaʻahaʻa. ʻO kāna papa hana, ka rosuvastatin, he mea mālama i ka hoʻokūkū koho o ka 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase), he enzyme e hoʻololi ana i ka HMG-CoA i mevalonate, kahi mea mua o ka kolesterol.

Ma ka hoʻonui ʻana i ka nui o nā receptor lipoprotein haʻahaʻa (LDL) ma ka pae o nā hepatocytes, hoʻonui ka rosuvastatin i ka uptake a me ka catabolism o LDL, keʻae i ka synthesis o nā lipoproteins haʻahaʻa haʻahaʻa (VLDL) a hōʻemi i ka nui o ka LDL a me VLDL. He hoʻohaʻahaʻa ia i nā pae kiʻekiʻe o ka kolamu LDL, ka nui o ka kolamu, triglycerides (TG), VLDL cholesterol, TG-VLDL, non-HDL cholesterol (kiʻekiʻe density lipoproteins), apolipoprotein B (ApoV). E hoʻomoʻa ka hoʻonui i ka neʻe o ka HDL cholesterol a me ApoA-I. Hoʻololi i ka ratio o ke kolamu-LDL i ka cholesterol-HDL, ka nui o ka cholesterol i ka cholesterol-HDL, ʻaʻole ka HDL cholesterol i ka HDL cholesterol, apolipoprotein B (ApoB) i ka apolipoprotein A-I (ApoA-I).

ʻO ka hopena hypolipidemic o Rosart e hilinaʻi pololei i ka nui o ka nui o ka lāʻau i kuhikuhi ʻia. Hoʻopuka ʻia ka hopena therapeutic ma hope o ka hebedoma mua o ka lapaʻau, ma hope o nā pule ʻelua he hiki i ka 90% o ka hopena loa, a ma ka hopena ʻehā - 100% a mau mau ka hoʻomau. Hōʻike ʻia ka Rosuvastatin no ka mālama ʻana i ka hypercholesterolemia me ka / me ka hypertriglyceridemia, ʻaʻohe o ke ʻano o ke ʻano wahine, ʻano a i ʻole ka iwi o ka mea maʻi, me ka poʻe maʻi me ka maʻi mellitus a me ka hypercholesterolemia familial. Hōʻike nā hopena o nā haʻawina ʻoiai ke lawe nei iā Rosart i kahi maʻa o 10 mg no ka type IIa a me IIb hypercholesterolemia (ka helu Fredrickson) me ka pākeke palapona LDL kolamu o 4.8 mmol / L, ua komo ka LDL cholesterol i nā waiwai ma lalo o 3 mmol / L ma 80 % o nā mea maʻi. Me ka hypercholesterolemia ʻohana homozygous, ka hoʻohaʻahaʻa ʻana o nā pae kolamu LDL me ka rosuvastatin ma ke ʻano o 20 mg a 40 mg ʻo 22%.

Hoʻohui kekahi hopena hoʻohui i ka hui pū ʻana o Rosart me ka acid nicotinic ma kahi o 1000 mg a i ʻole i kēlā me kēia lā (e pili ana i ka hoʻonui ʻana o ka kolamu HDL) a me ka fenofibrate (e pili ana i ka emi ʻana o ka manaʻo o TG) i ʻike ʻia.

Lapaʻau lāʻau

Ma hope o ka lawe ʻana i ka pill C_max (ka uka nui) o rosuvastatin i loko o ke kaila koko a hōʻea ma hope o ka mau hola 5. Hoʻonui ka hoʻonui ʻana i kona ʻōnaehana ma ka hapa i ka hopena i lawe ʻia. ʻO ka bioavailability kūpono e pili ana i ka 20%. ʻAʻole loli ia nā lālaki pharmacokinetic o kēlā me kēia lā.

ʻO ka pilina o nā protein plasma koko (i kahi nui aʻe me albumin) ma kahi o 90%. Hoʻohana ka nui o nā kōnoho. V_{e d} (ka helu hoʻoili) - 134 l. Ke lanakila nei ka lāʻau lapaʻau i ka pale placental.

He ia kahi-diea substrate no ka isoenzymes o ka ʻōnaehana cytochrome P₄₅₀. ^ E Ha yM. Ma kahi o 10% o rosuvastatin e biotransformed i loko o ka nui. ʻO ke kaʻina o ka uptake rosuvastatin i loko o ka puʻu e hana me ke komo ʻana o kahi mea lawe membrane kūikawā - ka polypeptide, ka mea halihali i ka anion organik (OATP) 1B1 a lawe i kahi nui i kona nepatic eliminations. ʻO ka isoenzyme CYP2C9 ka isoenzyme nui o ka metabolism o rosuvastatin, i kahi liʻiliʻi CYP3A4, CYP2C19 a me CYP2D6.

ʻO nā metabolits koʻikoʻi o ka rosuvastatin ka pharmacologically diactiv lactone metabolit a me N-desmethyl, kahi mea ma kahi o 50% e emi i ka hana ma mua o ka rosuvastatin. Hōʻike ʻia ka hoʻohanohano ʻana o ka hoʻōla ʻia ʻana o ka HMG-CoA e ʻoi aku ka nui o nā ʻekena 90% o ka lāʻau lapaʻau ʻo rosuvastatin, ʻo ke koena

10% - ka hana o kāna mau metabolites.

I loko o ke ʻano i loli ʻole, ma kahi o 90% o ke kūkaʻa o Rosart e kaomi ʻia ma o ka ʻōpū, a me ke koena ma o nā keiki. T_1/2 (hapalua-ola) - aneane 19 mau hola, me kahi piʻi o ka lāʻau o ka lāʻau, ʻaʻole ia e loli. Hoʻolaha nā lālani plasma 50 l / h.

Me ka maʻalahi a me ka paʻakikī o ka hikiʻole o ka renal, kahi hoʻololi nui i ka ka nui o ka neʻe o ka rosuvastatin i loko o ke koko koko a i ʻole N-desmethyl ʻaʻole i hele mai. I ka hopena o ka renal maikaʻi ʻole me ka cleince cleince (CC) ma lalo o 30 ml / min, i nā kiko o rosuvastatin i ka plasma e piʻi 3 manawa, N-desmethyl - 9 mau manawa. I ka poʻe maʻi i ka hemodialysis, ke piʻi ʻana o ka manaʻo o rosuvastatin i ka plasma e pili ana i ka 1/2.

I nā ʻāpana āpau o ka hina ole o ka ate (7 mau maka a lalo ma luna o ke keiki - Pugh scale), kahi hoʻonui o T_1/2 ʻaʻole i ʻike ʻia. Hai Alohaha T_1/2 Ua loaʻa iā rosuvastatin i 2 mau manawa i ʻike ʻia i nā mea maʻi me ka hōʻoki o ka ate ma nā hola 8 a me 9 ma ka ʻōnaehana Child-Pugh. Me nā hana pulima ʻē aʻe i hoʻolaha ʻia, ʻaʻohe ʻike me ka hoʻohana ʻana i ka lāʻau.

ʻAʻole loaʻa i nā hopena koʻikoʻi nā pharmacokinetics o rosuvastatin i ka wahine a me nā makahiki o ka mea maʻi.

Hoʻopili ka pili lāhui i nā ʻōmole pharmacokinetic o Rosart. ʻO ka plasma AUC (ʻōpili piha) o ka rosuvastatin ma Kina a me Iapana he 2 mau manawa iʻoi aku ma mua o ka poʻe ʻEulopa a me ʻAmelika ʻAmelika. C_max a me AUC i nā India a me nā ʻelele o ka lāhui Mongoloid ma ka awelika hoʻonui ʻia e 1.3 manawa.

Nā hōʻailona no ka hoʻohana ʻana

• hypertriglyceridemia (type IV ma muli o Fredrickson) - i mea hoʻonui i ka meaʻai,
• ʻO ka hypercholesterolemia maʻamau (type IIa e like me Fredrickson), me ka heterzygous herdary hypercholesterolemia, a i hui pū ʻia (hoʻohui ʻia) hyperlipidemia (type IIb ma muli o Fredrickson) - i mea hoʻohui i ka meaʻai, ka hana kino a me ke kaumaha.
• ʻO ka ʻano homozygous o ka maʻi hypercholesterolemia me ka ʻole o ka lawa o ka hopena o ka meaʻai a me nā ʻano ʻē aʻe e pili ana i ka hoʻohaʻahaʻa ʻana i ke kiʻekiʻe o ka lipid kūloko (me ka LDL-apheresis) a i ʻole ka intolerance pilikino i kēlā mau ʻano hana.
• ka pale mua ʻana o nā hoʻopiʻi cardiovascular (hōʻeha o ka naʻau, ka hōʻeha, ka revascularization arterial) i nā pākeke me nā hōʻailona ʻole o ka maʻi coronary heart disease (CHD), akā me nā mea pono no kona hoʻomohala ʻana (ʻoi aku nā kāne no ka ʻoi aku o 50 mau makahiki a no nā wahine ʻoi aku ma mua o 60 mau makahiki, ka nānā ʻana C -resa protein o 2 mg / l a kiʻekiʻe i mua o ka liʻiliʻi i kekahi o nā mea hou aku: nā neʻe hypertension, haʻahaʻa HDL kolamu, ka hoʻomaka mua o ka maʻi naʻau coronary i loko o ka mōʻaukala, ka ulaula).

Eia kekahi, ua kuhikuhi ʻia ʻo Rosart i ka mea i hoʻolaʻa i ka meaʻai no nā poʻe maʻi e hōʻike ʻia ana i ka lāʻau e hoʻohaʻahaʻa i ka kolamu a me ka kolamu LDL i mea e lohi ai ka holomua o ka atherosclerosis.

Rosart analogs, papa inoa o nā lāʻau lapaʻau

ʻO ka lāʻau antisclerotic he nui nā analogue me nā waiwai lapaʻau like like. Eia nō naʻe, ʻaʻole ia e kau ʻia e kau i kekahi lāʻau lapaʻau me kekahi mea ʻē aʻe (no ka laʻana, no ka pānaʻi kumu. Hiki i kēia ke alakaʻi i ka mea i hiki i ka lāʻau lapaʻau i koho ʻia ke hopena maikaʻi i ke kino, e hōʻike ana i nā hopena ʻaoʻao a i ʻole ke loaʻa i ka hopena therapeutic kūpono.

Nā kikowaena maʻamau o Rosart:

1. Akorta. He kānana hoʻolaʻa haʻahaʻa kēia e kōkua i ka hoʻonui ʻana i ka helu o nā receptor lipoprotein haʻahaʻa, e alakaʻi ana i ka hoʻoemi o ka cholesterol kino.
2. ʻOkaʻohana. Hōʻike hoʻi nā papa i ko lākou hopena i ka palā (aia kekahi heʻelihe metabola o nā lipoproteins haʻahaʻa haʻahaʻa me ke ʻano o ka cholesterol). I ka hoʻonui ʻia ʻana o ka nui o nā receptors hepatic i nā membranes e hoʻonāukiuki i ka catabolism a me ka hopu ʻana i nā lipoproteins haʻahaʻa haʻahaʻa.

Hoʻolālā pū kekahi kikowaena lāʻau lapaʻau - Rosucard, Rosistark, Tevastor.

Pono - ʻaʻole e pili ʻia nā ʻōlelo a Rosart no ka hoʻohana ʻana, ke kumukūʻai a me nā loiloi i nā kikowaena a hiki ʻole ke hoʻohana ʻia i alakaʻi no ka hoʻohana ʻana i nā lāʻau lapaʻau o nā ʻano like a i ʻole ka hopena. Pono nā ʻōlelo lapaʻau āpau e pono e ke kauka. Ke hoʻololi nei iā Rosart me kahi analogue, he mea nui ia e kiʻi i ka ʻōlelo aʻo loea; pono paha ʻoe e loli i ka papa o ka maʻi, nā ʻano, a me nā mea pono ʻole.

Hoʻohui ʻia nā loiloi o nā kauka e pili ana iā Rosart. ʻO nā hiʻohiʻona maikaʻi, hiki ke hoʻomaopopo ʻia kahi hopena hopena maikaʻi a lōʻihi e ulu nei no kekahi manawa pōkole. Ma kekahi ʻaoʻao, paʻakikī paha ke koho i kahi kaohi kū hoʻokahi. Loaʻa kekahi poʻe maʻi i ka pilikia ma ka wā o ka mālama ʻana, no ka mea e hāʻawi lākou i ka kīʻaha ʻona, a me ka ʻike ʻole i ka liʻiliʻi liʻiliʻi.

Nā hopena hopena

Loaʻa nā hopena ʻaoʻao. Pono i hōʻike ʻia nā hopena ʻokoʻa i kāu kauka inā hoʻomau a hoʻomau lākou paha.

ʻO nā hopena pili eʻoi aku ka koʻikoʻi. Inā loaʻa, pono ʻoe e hoʻokaʻawale i ka lawe ʻana iā Rosart a kiʻi koke i kahi kauka. ʻO kēia mau hiʻohiʻona maikaʻi aʻe ka:

• ʻeha nāwaliwali a nāwaliwali paha
• fiva,
• ʻeha ka ʻōpū
• ka melemele o ka ʻili a i ʻole nā ​​maka,
• pōʻeleʻele
• ʻeha ma ka ʻōpū ʻākau ʻākau,
• ninini
• luhi loa
• hū ʻole a i ʻole ka pohō
• lilo ka momona
• nā maʻi maʻamau-like,
• ʻeha ka ʻeha, hōʻeha, a i ʻole nā ​​hōʻailona ʻē aʻe o ka maʻi.

Inā loaʻa kahi hōʻailona o kahi hopena alaka, pono e hoʻokaʻawale koke i ke ʻano mālama olakino:

• ʻohiʻala
• urticaria,
• huu,
• paʻakikī ka hanu a me ka make ʻana,
• ka māla ʻana helehelena, ʻāʻī, lehe, nā lehelehe, nā maka, nā wāwae, nā ʻūhā a me nā wāwae i lalo.
• kaulohelohe
• ʻehaʻī a nānā paha i ka manamana lima a me nā manamana wāwae.

Nā ʻōkuhi no ka hoʻohana iā Rosart

I nā ʻōlelo aʻoaʻo no ke hoʻohana, ʻōlelo ʻia ʻo Rosart 10 mg e lawe ʻia ka lāʻau i ke ʻano me ka ʻole o ka wili ʻana. E inu i ka lāʻau lapaʻau me ka nui o ka wai, ʻoi aku ka maikaʻi o ka wai. ʻO ka lawe ʻana i nā paila he kūʻokoʻa ʻole ka ʻu ʻana o ka meaʻai.

Wahi a Rosart e pili ana i ka hoʻohana ʻana, he 10 milligrams, pono pono e lawe ʻia ka lāʻau lapaʻau me ka hapa liʻiliʻi o ka 5 milligrams a i ʻole 10 milligrams, ʻoiai inā i lawe ʻia nā koina kiʻekiʻe o nā statins mua. Ke koho ʻia nei ke ʻano o ka dosage mua ma mua:

• kolene kiʻekiʻe
• ka pae o ka ʻeha o ka naʻau a i ʻole ka hahau,
• hiki ke hoʻopau ʻia i nā ʻāpana o ka lāʻau.

Me ka hoʻomakaʻana o ka 5 miligrams, hiki i ke kauka ke hoʻopiʻi i kēia wai i ka 10 milligrams, a laila e hoʻonui i 20 milligrams a me 40 milligrams, inā pono.

ʻEhā mau hebedoma e hoʻohemo ma waena o kēlā me kēia hoʻoponopono ʻia. ʻO ka palena nui o kēlā me kēia lā he 40 milligrams. Hoʻomaopopo ʻia kēia ʻano maʻi i nā maʻi me ka kiʻekiʻe o ka kolamu a me ka nui o ka puʻuwai o ka hōʻeha ʻana o ka naʻau a i ʻole ka maʻi hōʻā, kahi kahi ana o 20 milligrams e lawa e hoʻohaʻahaʻa i ka cholesterol koko.

Ke koho ʻana i kahi lāʻau lapaʻau e hōʻemi i ka hopena puʻuwai puʻuwaia hahau paha
nā pilikia olakino kūpono, ʻo ka dosis i makemake ʻia i kēlā me kēia lā he 20 mg. Hiki ke hōʻemi ʻia ka dosage inā loaʻa i nā maʻi he mau hōʻailona ma ka papa inoa o nā contraindications.

ʻO ka dosis no nā keiki he ʻumi a ʻumikumamāhiku mau makahiki - ʻo ka nui o ka hana mua ma mua o 5 milligrams, ʻo ka 20 mg nui loa o kēlā me kēia lā. Pono ka lāʻau i ka manawa hoʻokahi i ka lā.

ʻO ka lāʻau lapaʻau ʻo Rosart, e like me nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana, ma kahi pāʻina 40 mg ʻaʻole i ʻōlelo ʻia no nā keiki.

Hoʻopili pū me nā lāʻau ʻē aʻe

ʻO Rosart, ʻoiai e lawe pū ana me kekahi mau lāʻau lapaʻau, hiki ke hoʻonāukiuki i ka hōʻike ʻana o nā ʻanoʻano kūpono ʻole:

• Hoʻokipa ʻana ʻo Rosart me ka Cyclosporine - ke hoʻoikaika nei ka lāʻau hope loa i ka nui o ka hoʻonui ʻana i ka hoʻolaha ʻana i nā ʻōnaehana rosuvastatinno laila, ʻo nā mea maʻi e kau ʻia nei e mālama ʻia ʻo Cyclosporine e lawe iā Rosart i ka palena liʻiliʻi loa - ʻaʻole ʻoi aku o 5 mau milligram i kēlā me kēia lā.
• Hemofibrozil (Gemfibrozil) - hoʻonui nui i ka hoʻolaha ʻōnaehana o rosuvastatin. Ma muli o ka ʻike i hoʻonui ʻia o ka nui o ka myopathy / rhabdomyolysis, pono e pale ʻia i ka hui ʻana o Rosart a me Gemfibrozil. Pono e hoʻonui ka nui o ka nui ma ka 10 milligrams i kēlā me kēia lā.
• Nā mea hoʻomaloka piha - nā hui hoʻohui o Rosart me kekahi mau proteitor inhibitors i hui pū ʻia me ritonavir i nā hopena like ʻole i ka rosuvastatin, a ʻoi aku ka ʻoi o ka hopena o ka waiwai ma ke kino. Nā Hoʻolālā Protease i nā Hoʻohui: lopinavir / ritonavir a atazanavir / ritonavir hiki ke hoʻonui i ka kūkala systemic o ka rosuvastatin a ʻekolu mau manawa. No kēia hoʻohuiʻana, ʻaʻole pono kahi o Rosart eʻoi aku ma mua o 10 milligrams hoʻokahi i ka lā.

Nā hōʻailona no ka hoʻohanaʻana i ka lāʻau lapaʻau

Hōʻike ʻia ka noi Rosart ma kēia mau hihia:

• ʻO ka hoʻonui nui aʻe o ka pae o ka kolamu maʻamau, ke komo pū me ka maʻi maʻi genetically, a me kahi ʻano i hui ʻia.

• Hoʻokomo ʻia nā triglycerides ma ke koko.
• Me ka atherosclerosis - e lohi i ka holomua o ka maʻi.
• ʻO ka paleʻana i nā hoʻopiʻi ischemic i nā poʻe e hōʻeha nei i ka maʻi puʻuwai a me ka maʻi vascular me ka nui o ka hoʻomohala: ʻo ka inu ʻana, ka inu ʻana i ka waiʻona, ʻoi aku ka nui o nā makahiki he 50, ka predisposition poʻokela, hypertension arterial, kiʻekiʻe o ka C-reactive protein.

Hoʻohana nui ʻia ka lāʻau lapaʻau ma ka hana therapeutic no ka mālama ʻana a no ka pale ʻana i nā pilikia o nā maʻi cardiovascular. I kēia manawa, ua kuhikuhi ʻia ka lāʻau lapaʻau a Rosart a me nā mea e hoʻopili ai no ka hapa nui o nā poʻe maʻi me ka kolokoli koko kiʻekiʻe me kahi mea lapaʻau pono ʻole.

Hoʻohana maikaʻi a me ka statin

ʻAʻoleʻai koʻikoʻi nā mea kanu i ka wā e mālama ai i ka hypercholesterolemia - mai 2400 a 2700 mau kalona i kēlā me kēia lā. Eia kekahi, ʻaʻole pono ka ʻai e ʻai ai:

• momona, ʻaʻai ʻaihina, a me ka meaʻai i mākaukau ma ka paila a me ka grill,
• nā meaʻai i ʻaʻa ma nā momona a me ka aila,
• hua manu - ma mua o ʻekolu mau ʻokoʻa i ka pule.
• pata
• iʻa momona momona a me nā iʻa,
• huakai, mea palaka, ʻuʻu, aspic,
• waiū a pau ma mua o 2,5%, ʻōmole wai, kaʻaila,
• Bacon, puaʻa

• pepi pipi
• E hoʻonohonoho me ka waiū a me nā puna momona.

ʻO kahi kīʻai me ke kolamu kiʻekiʻe e pono e hoʻohui i kahi helu o nā mea kanu a me nā hua. Pono nā lau ʻai i nā lau i loko o nā salads, kaʻa ʻia, a me nā mea i kuke ʻia, nā ʻano mea kuke ʻia. Lāpule, hoʻomākaukau ʻia nā compotes mai nā hua, ʻai ʻia me ka meli. Ma ke kumu o ka protein no ka kuke ʻana, ua hoʻohana ʻia nā pākīkī pōkole momona haʻahaʻa a me ka ʻiʻo lau manu (moa, veal, rabbit, turkey). Paipai ʻia ka hoʻohana ʻana i nā hua cereal.

Pono ka papa ʻaina i kēlā me kēia lā i nā meaʻai - mai ka ʻehā a ʻeono. Paʻa ʻia nā meaʻai i kahi lā mahana. Pono ʻoe e inu i ka liʻiliʻi a i ka hapa lita o ka wai i kēlā me kēia lā, me ka hoʻohui i nā meaʻala, nā ʻala, ʻala.

Hoʻoholo nā Rosart i koho ʻia

I nā hihia ʻaʻole i hāʻawi ka hoʻohana ʻana i ka meaʻai i ka hopena i makemake ʻia a noho mau ka kolamu ma kahi kiʻekiʻe, ke kuhi ʻia nā papa Rosart a i ʻole nā ​​statins ʻē aʻe. Hiki ke inu ʻia nā papa i kēlā me kēia manawa o ka lā, me ke ʻano o ka manawa e ʻai ai. Pono ka holoi ʻana i ka lāʻau me ka wai maʻemaʻe. ʻO ka meaʻai hypolipidemic i hōʻike ʻia ma luna nei e ukali i ka wā o ka mālama statin. Kahi ʻia ka hopena o ka lāʻau i kēlā me kēia hihia. Ma ke kānāwai, hoʻomaka ke ʻano ʻo Rosart me ka liʻiliʻi loa o ka 5 mg. I kekahi manawa, me nā helu kolikolo kiʻekiʻe kiʻekiʻe, ʻo ka hoʻomaka hoʻomaka ʻana paha 10 mg o ka lāʻau. Kēia mau pule ma hope o ka hoʻomaka ʻana o ka lapaʻau, me ka mālama ʻana o ka mālama ʻana, piʻi ka nui ma 20 mg. ʻO ka hoʻohana mau i nā lāʻau lapaʻau e hoʻohaʻahaʻa i ka cholesterol lā mau loa, i kekahi manawa i ka wā o kou ola.

Ke keu

ʻAʻole paʻa i nā hōʻailona o kahi overdose o rosuvastatin. Hoʻokahi hewa hoʻokahi o nā helu i kēlā me kēia lā o Rosart ʻaʻole i pili i ka pharmacokinetics.

Hoʻomaʻamaʻa: ka koho ʻana o ka therapy hōʻailona. Pono ka mālama ʻana i ka hana o ka phosphokinase (CPK) a me nā ʻano o nā ate. Inā pono, ua lawe ʻia nā hana e mālama ai i nā hana o nā ʻiʻo koʻikoʻi a me nā ʻōnaehana.

ʻAʻole like ka maikaʻi o ka hemodialysis.

Nā ʻōlelo kikoʻī

Hoʻopili ʻia ka hopena o ka hoʻomohala ʻana i ka myopathy, ʻo ia hoʻi me ka rhabdomyolysis aʻo ka lawe ʻana i ka rosuvastatin me nā huaʻala me ka ʻai aʻe nei: cyclosporine, HIV protease inhibitors, ʻo nā hui pū ʻana o ritonavir me ka atazanavir, tipranavir a me / a i ʻole lopinavir. No laila, pono e hāʻawi ʻia i ka noʻonoʻo i ke koho ʻana i nā ʻano hoʻonaninani ʻē aʻe, a inā pono, pono e hoʻoki ʻia ka hoʻohana ʻana o kēia mau kālā - ʻo ka maʻi me ka rosuvastatin

Ke hoʻohana nei iā Rosart i kahi maʻa o 40 mg, pono ia e kiaʻi pinepine i nā hōʻailona o ka hana renal.

I ka hoʻoholo ʻana i ka hana o CPK, pono ia e hoʻokaʻawale i ke alo o nā mea e hoʻonāukiuki i ka hilinaʻi o nā hopena, me ke ʻano o ka hana kino. ʻO nā maʻi me ka hoʻonui nui ʻana i ka hana mua o ka CPK pono e nānā hou ma hope o nā lā 5-7. Ma ka hōʻoia o ka hōʻoia i ka ʻelima o ka nui o ka maʻamau o ka hana KFK, ua hoʻohana ʻia ka hoʻohana ʻana i ka lāʻau.

Pono ka mālama kūikawā e kuhikuhi ana iā Rosart i nā poʻe maʻi me nā mea e pili ana i ka hoʻomohala ʻana i ka myopathy a i ʻole rhabdomyolysis, e nānā pono ana i ka pae o nā pōmaikaʻi i manaʻo ʻia a me nā hopena e hiki mai ana i ka lāʻau lapaʻau. Pono e mālama ʻia ka nānā ʻana i nā lāʻau lapaʻau no kēia ʻano o nā maʻi i ka holo ʻana o nā maʻi. ʻAʻole hiki iā ʻoe ke hoʻomaka e lawe i nā papa me ka hana mua o ka CPK 5 mau manawa ma mua o ka palena kiʻekiʻe o ka maʻamau.

Pono ke kauka e hoʻomaopopo i ka mea maʻi e pili ana i ka hiki ʻana mai o ka ʻeha o ka naʻau, malaise, ke kuni, ka nāwaliwali o ka naʻau a i ʻole kaʻauʻau ma ka wā o ka mālama ʻana, a pono hoʻi e ʻimi koke i nā ʻōlelo lapaʻau. Me ka piʻi nui o ka hana KFK a i ʻole nā ​​ʻehaʻeha o ke ʻano, pono e hoʻokuʻu ʻia ka lāʻau maʻi. Me ka nalo ʻana o nā hōʻailona a me ka hoʻihoʻi ʻana o ka mākau hana hana KFK, hiki ke kuhikuhi hou i ka lāʻau lapaʻau i nā kiʻī liʻiliʻi.

ʻO 1-2 mau manawa i kēlā me kēia mahina, pono ke nānā ʻia ka ʻike lipid ma ka hoʻoponopono ʻana o Rosart e like me nā hopena.

Me ka mōʻaukala o ka maʻi paleka a me nā mea maʻi e hōʻino maikaʻi aku i ka waiʻona, ua kuhikuhi ʻia ma mua o ka hoʻomaka ʻana o ka lāʻau a ma hope o ʻekolu mau mahina o ka hoʻohana ʻana i ka lāʻau lapaʻau, hoʻoholo ʻia nā hōʻailona hana maʻi. Inā he hana o ka hoʻouluulu hepatic i loko o ke koko serum he 3 mau manawa iʻoi aku ma mua o ka palena o ka maʻamau, pono ʻoe e hōʻemi i ka nui o ka hopena a paʻa paha ke lawe iā Rosart.

No ka mea ʻo ka hui pū ʻana o nā mea paʻa o ka protein o ka HIV me ka ritonavir e hoʻonui i ka pae o ka laka o ka rosuvastatin, he pono ka hoʻokaʻawale ʻia ʻana o ka nohona lipid koko, he pono paha e hoʻonui ʻia ka ʻike ʻana iā rosuvastatin i ka plasma koko me ka hoʻomaka ʻana o ka hoʻōla a ma ka manawa o ka hoʻonui ʻana i ka hopena o ka lāʻau, a e pono e hoʻoponopono ʻia nā hoʻoponopono kūpono.

Ke koi nei ka hoʻopau ʻana ma ka lā inā he kānalua ka maʻi maʻi interstitial, hiki iā ia ke hana i ka pōkole o ka hanu, ka wīwī hua ʻole, nā nāwaliwali, nā hoʻoluhi luhi, a me nā maʻi.

ʻŌpū a me ka lactation

Wahi a nā ʻōlelo kuhikuhi, ua contraindicated ʻo Rosart i ka manawa o ka wā gestation a me nā umauma.

ʻO ka koho ʻana i ka lāʻau i nā wahine o nā makahiki hānau o ke ʻano pono e hana wale nō i ka hoʻohana ʻana i nā hana contraceptive kūpono.

Pono e hoʻomaopopo ʻia ka mea maʻi i ka hopena o ka hiki i ka ʻōpū ma ka hihia o ka ʻāʻī ʻana i ka wā mālama.

Inā pono e lawe iā Rosart i ka wā lactation, pono e oki ʻia ka ʻōpū.

Me ka hana pūnāwai paʻa ʻole

Hoʻohana ʻia ka hoʻohana ʻana o Rosart i kekahi o nā kaila no ka hiki ʻole o ka renal maikaʻi ʻole me CC ma lalo o 30 ml / min, ma kahi pākēneka o 40 mg - me CC mai 30 a 60 ml / min.

Me ka hoʻohaʻahaʻa ʻole a hōʻemi haʻahaʻa o ka hopena o ka renal, ʻaʻole i koi ʻia ka hoʻoponopono ʻana, ʻaʻole ʻia ka hopena mua me CC ma lalo o 60 ml / min pono he 5 mg.

Me ka hana pūpū hemahema

Ke hoʻololi nei i ka hala o ka rosuvastatin, ʻaʻole pono no ka hemahema o ka 7 mau māka a i ʻole ka haʻahaʻa ma ke kākuhi ʻo Child-Pugh, me 8 a 9 mau kikoo ma ke kūloko o ke keiki-Pugh, pono ke hoʻokō ʻia ka koho ma hope o ka loiloi mua o ka loiloi hana.

Loaʻa ka ʻike me Rosart ma ka poho ole ma luna o 9 mau wahi ma ka laulā keiki-Pugh.

Hoʻohui nūhou

Me ka hoʻohana ʻana iā Rosart:

• nā hua lāʻau e hoʻoneʻe ana i nā ʻōmua halihali, ʻo ka mākaʻi o ka rosuvastatin, hoʻonui i ka hiki ke hoʻomohala i ka myopathy,
• Hoʻokumu ka cyclosporine i ka nui o ka hopena i ka hopena o ka rosuvastatin, e hoʻonui ana i kona kaila nui loa i loko o ke koko koko e 11 mau manawa,
• Ua hoʻonui nui ka erythromycin C_max e 30% a me ka emi ʻana o AUC o rosuvastatin ma 20%,
• ʻO ke warfarin a me nā anticoagulants kūloko hiki ke haki i ka hoʻowalewale MHO (ka pae ʻāina maʻamau maʻamau e hoʻohana ʻia no ka hoʻoholo ʻana i ka hōʻailona o ka ʻōnaehana coagulation koko): i ka hoʻomaka ʻana o ka hoʻohana a me ka piʻi ʻana o ka hopena o ka rosuvastatin, he hoʻonui i ka MHO, a i ka wā e hōʻoki ai i ka hōʻemi ʻana i ka maʻa o ka rosuvastatin, he hōʻemi i loko o INR, no laila ke nānā ʻia ka mālama ʻana. MHO
• nā lipid-kaila haʻalulu, me ka gemfibrozil, e hoʻonui i ka AUC a me C_max 2 mau wā rosuvastatin,
• nā antacids e loaʻa ai ka alumini a me ka magnesium hydroxide e hōʻemi i ka plasma o ka lāʻau i ka manawa 2,
• hoʻonui ka waha i ka waha o ka AUC o ka ethinyl estradiol ma 26% a me ka norgestrel e 34%,
• fluconazole, ketoconazole a me nā lāʻau lapaʻau ʻē aʻe nā mea e pale aku ai i nā isoenzymes CYP2A6, CYP3A4 a me CYP2C9 ʻaʻole i kumu i kahiʻoihana koʻikoʻi o ka maʻi.
• ezetimibe (ma ke ʻano o 10 mg) i nā mea maʻi me ka hypercholesterolemia hoʻonui i ka AUC o rosuvastatin (ma kahi kiko o 10 mg) e 1,2 mau manawa, hiki i ka hiki ke hoʻomohala ʻia nā hanana ʻino.
• Hiki i nā inhibitor ka HIV protease ke alakaʻi i ka nui o ka hoʻolaha ʻana i ka rosuvastatin,
• ʻaʻole kahi digoxin i kahi pilina koʻikoʻi koʻikoʻi.

I ka wā o ka hoʻohana ʻana i ka rosuvastatin, pono ʻoe e nīnau i ke kauka inā pono e hoʻohui pū me ia me nā lāʻau ʻē aʻe.

ʻO nā mea hoʻohālikelike a Rosart nā: Akorta, Actalipid, Vasilip, Lipostat, Mertenil, Medostatin, Zokor, Simvakol, Rosuvastatin, Krestor, Rosucard, Rosistark, Rosulip, Torvazin, Tevastor, Kholetar.

Hōʻike ʻo Rosart

ʻO ka loiloi e pili ana iā Rosarte, he kūpono loa. Hoʻomaʻamaʻa nā maʻi i ka hopena therapeutic wikiwiki, e hoʻoikaika ana i ka hāʻule ʻana o ka cholesterol me ka hoʻomaka ʻana o nā papa, akā ʻo ka hoʻohana maʻamau i ka lāʻau e pono ai e mālama i kona mau waiwai i loko o nā palena maʻamau.

Hoʻomaʻamaʻa kekahi mau mea maʻi e pili ana i ke ʻano ʻino i loko o ke ʻano he itching a me ka ʻū, ke hoʻohaʻahaʻa i ke koko, ke ʻano o ke poʻo ʻeha a me ka ʻeha e hiki ai. Akā i ka laulā, ua hōʻike ʻia e hāʻawi ʻo Rosart i nā hopena liʻiliʻi e like me nā hopena like ʻole. No nā mea he nui, ʻo ke kumukūʻai o ka lāʻau lapaʻau ka mea kiʻekiʻe.

He kumukūʻai ʻo Rosart i nā lāʻau lapaʻau

Kūpaʻa ʻia ke kumukūʻai ʻo Rosart ma ka dosage:

• ʻO Rosart 5 mg no kēlā me kēia papa o 30 mau papa - mai 400 mau rubles, 90 papa - mai 1009 mau rubles,
• Rosart 10 mg no nā pā o 30 mau papa - mai 569 rubles, 90 papa - mai 1297 mau rubles,
• ʻO Rosart 20 mg no ka pā o 30 mau papa - mai 754 mau rubles, 90 papa - mai 1954 mau rubles,
• Rosart 40 mg no nā pā o 30 mau papa - mai 1038 rubles, 90 papa - mai 2580 rubles.

Nā noi noi

ʻO ka weheweheʻana i ka hoʻohana ʻana i kahi lāʻau mai ka index cholesterol kiʻekiʻe me ke kumu nui o ka rosuvastatin - Rosart:

• Hoʻomaka ka hoʻomaka ʻana o nā lāʻau lapaʻau me ka lāʻau lapaʻau Rosart me ka ʻai kolala, e hele pū ana i ka papa holoʻokoʻa o ka hopena me nā statins,
• E haʻi aku ke kauka e hele aku i ke ʻano e lawe iā Rosart, a me ke ʻano kū hoʻokahi i koho ʻia e ke kauka e like me nā kuhikuhi ʻana o ka biochemistry me kahi kikoʻī (lipograms).
• Pono ke ʻāpana ʻāpana Rosart a ʻūhā, ʻaʻole e ʻauʻau me ka wai nui. ʻAʻole pono e hoʻopili i ka lāʻau lapaʻau i kahi ʻai, pono ʻoe e makaʻala i ka manawa kūpono o ka hoʻokomo o kēlā me kēia lā. Noia ia e lawe iā Rosart i ke ahiahi ma mua o ka moe, a me kēia no nā bioprocesses i loko o ke kino kanaka, a mai ka manawa o ke kaha kaha o ka cholesterol e nā ʻōpū o nā pepeka,
• ʻO Rosart ka helu mua o 5.0 a 10.0 milligrams, hoʻokahi lā i kēlā me kēia lā,
• Hiki i ke kauka hele wale nō ke hoʻonui i ka dosage a i ʻole ke hoʻololi i ka lāʻau lapaʻau me ka analogue, akā ʻaʻole ia ma mua o ka mahina o ka mālama ʻana o Rosart. Hōʻike ka piʻi nui o ka maʻi e like me nā hopena o nā maʻi biochemical a inā he hopena ʻole ka nui o ka laikini.
• ʻO ka nui loa ka nui o kēlā me kēia lā - 40.0 milligrams, ua kau ʻia i nā mea maʻi e loaʻa ana i ka maʻi kiʻekiʻe o ka hoʻokumu ʻana i nā pathologies cardiac a i ʻole nā ​​mākau o ke kaina holo koko, akā inā wale nō ka lāʻau lapaʻau Rosart me kahi keneta o 20.0 milligrams ʻaʻole i lawe mai i nā hopena i kahi hōʻemi o ka waihona ʻAmelika (me ka hypercholesterolemia o ka genetic a i ʻole familial etiology). ʻO ka mālama ʻana me kahi maʻi o Rosart i 40.0 milligrams e lawe wale ʻia i ka hale haukapila ma lalo o ka mālama mau ʻana o kahi kauka.
• Ua kau ʻia nō ka nui o ka nui o ka maʻi no ka poʻe maʻi e loaʻa hou ana i ka atherosclerosis systemic,
• Me ka hoʻomanawanui me kahi maʻi o ka 10,0 milligrams, nānā i ka index cholesterol a me nā helu transaminase - ma hope o 14 mau lā o ka hoʻokele ʻana.
• Me kahi haʻahaʻa o ka hoʻomohala ʻana i nā ala o ke kino renal, ʻaʻohe mea e pono ai ka hoʻoponopono ʻia, a ʻaʻole i hoʻoponopono ʻia ke ʻano ma kekahi makahiki ʻoi aku - ʻoi aku ʻo ia ma mua o 70 mau makahiki, akā, e hoʻomaka ʻia ka mālama ʻana me ka 5.0 milligrams i kēlā me kēia lā.
• I ka lōʻihi loa o 40.0 milligrams i kēlā me kēia lā, kiaʻi mau i ka indexine phosphokinase index,
• Inā loaʻa i ka mea maʻi ka mōʻaukala o ka myopathy, a laila pono ke mālama ʻia ka lāʻau me ka dosis o Rosart ma ka 5.0 milligrams,
• ʻO nā mea maʻi me nā pathologies o nā pūpū o nā peka ma ke kiʻekiʻe o nā keiki-Pugh, a hiki i nā kumumanaʻo 7,0, ma mua o ka koho e hana i kahi maʻi kikoʻī ʻana a ʻaʻole i kuhikuhi i nā kiʻekiʻe aku ma mua o ka 5.0 milligrams i kēlā me kēia lā.

ʻOi aku ka kiʻekiʻe o ka papa o ka mea hana ikaika i ka papa, ʻoi aku ka nui o ka hopena maikaʻiʻole i ke kino mai kona alakaʻi.

Nā hōʻailona no ka koho

Kuhi ʻia ʻo Rosart no ka mālama ʻana i kēlā mau ʻano maʻi.

• ʻO ka ʻōpiopio heterozygous non-hereditary a familial type o ka hypercholesterolemia (type 2A e like me Fredrickson) i ka hoʻohui ʻana i ka meaʻai kolamu, a me ka hipopololiia-genetic ʻole, i ka hui pū me ka meaʻai, ke kaumaha ikaika i ke kino, a me ka mālama ʻana i ka pohō.
• Me kahi ʻano homozygous o ka hypercholesterolemia i ka hui pū ʻana me ka meaʻai, inā ʻaʻole kōkua ka meaʻai wale nō i ka hoʻohaʻahaʻa ʻana i ka index kolesterol,
• ʻO ka ʻano hyperlipidemia ʻano like ʻole (ʻano like ʻo 2B e like me Fredrickson), i hui pū me ka meaʻai kolamu,
• ʻO ke ala o ka dysbetalipoproteinemia (ʻano 3 e like me Fredrickson), me ka ʻai kai,
• ʻO ka etiology o ka ʻohana hypertriglyceridemia (Fredrickson ʻano 4) he kumu nui loa i ka meaʻai kolamu,
• I mea e pani ai i ka holomua o ka atherosclerosis systemic i hui pū me ka meaʻai, lawa ka hana kino, a me ka hoʻolilo ʻana.

Hoʻopilikia ʻia ka pale mua o nā lāʻau Rosart me ia mau ala:

• Me ka ʻano o ka reascularization,
• Ischemia ʻOi,
• ʻO ka infarction myocardial a me ka cerebral stroke,
• Me nā makahiki o ke kāne kāne he 50 a ʻo 55 mau makahiki i nā wahine,
• ʻO ka ʻai kiʻekiʻe o ka protein C
• Me ka hypertension
• Me ka hoʻohaʻahaʻa helu HDL cholesterol helu helu,
• Me ka hoʻohui molotine a me ka waiʻona.

Āhea hiki ʻole iaʻu e hoʻohana iā Rosart?

Kau kekahi ʻōlelo no ka hoʻohana ʻana iā Rosart i ka wehewehe ʻana i nā hihia i hiki ʻole ke kuhikuhi ʻia ka lāʻau lapaʻau. ʻO Rosart i nā waihona o 5, 10, 20 mg ua contraindicated ma kēia mau hihia:

1. ʻO nā wahine'ōpiopio ʻaʻole e hoʻohana i nā hana kūpono e pale aku i ka wā hāpai.
2. ʻO ka maʻi maʻi pūpū.
3. ʻO nā pae kiʻekiʻe o nā transaminases hepatic (enzymes) o kahi kumu ʻike ʻole.
4. ʻO nā maʻi o ke keiki, hōʻailona i ka hopena koʻikoʻi o ka hana.
5. ʻO kekahi mauʻano o ka maʻi metabolic.
6. Na keiki malalo o na makahiki 18.
7. Ke kaʻina hana Myopathic.
8. ʻO ka manawa mālama me ka cyclosporine.
9. ʻO ka manawa o ka gestation a me nā umauma.

ʻO nā papa Rosart e loaʻa ana i ka 40 mg o Rosuvastatin ka contraindicated ma nā maʻi ma luna aʻe a me nā kūlana physiological. Eia kekahi, ʻaʻole hiki ke hoʻohana ʻo Rosart 40 mg i:

1. Hoʻohana ʻia me nā lāʻau lapaʻau e pili ana i nā fibrates.
2. ʻO ka maʻi thyroid (hypothyroidism).
3. Ka inu maikaʻi ʻana i ka waiʻona.
4. ʻO Myopathies i ka wā ma mua ua hopena mai ka hoʻohanaʻana i nā statins a me nā fibrates.
5. Nā kūlana e hiki ke alakaʻi i ka piʻi nui o ke kaila o ka rosuvastatin.
6. ʻO ka hoʻoili ʻili ʻia no nā maʻi o ka ʻōnaehana o ka muscular.
7. Nā kihi i ka lāhui Mongoloid.

Hāpai a hānai i kahi pēpē

No ka mea hiki iā Rosart ke hele i ka pale o ka plasenta, ua contraindicated ka hoʻohana ʻana o ka lāʻau lapaʻau i ka wā o ka gestation.

Inā hiki i ka wā hāpai i ka wā o ka hoʻokele ʻana o Rosart, e hoʻopau koke ka lāʻau statin.

Ke koho nei i nā lāʻau lapaʻau Rosuvastatin i ka wahine o ka hānau ʻana o ka makahiki o ka poʻe i hoʻohana i nā ʻano kūpono o ke kohu a loaʻa ka nui o ka ʻōpū, pono ia e wehewehe i ka hopena hiki ʻole o ka hopena o ka lāʻau Rosuvastatin ma ka hapō. ʻAʻole i hōʻoia ʻia ka hiki o Rosuvastatin e komo i ka waiū umauma, akā ʻaʻole i hoʻokaʻawale ʻia. No laila, ʻaʻole i hoʻohana ʻia ʻo Rosart i ka wā o ka umauma.

E hoʻohana me Rosart me ka akahele

Eia kekahi, aia nā kūlana e hoʻohana ai ʻo Rosart, akā me ka akahele. Nā papa papaʻa he 5, 10 a me 20 mg o Rosuvastatin i kuhikuhi ʻia me ka akahele i loko o:

1. I ka loaʻa aʻe o ka myopathy.
2. ʻO nā ʻelele o ka lāhui Mongoloid.
3. Ma mua o 70 mau makahiki.
4. Hypothyroidism
5. ʻO ka predisposition hope loa i ka hoʻokumu i kaʻina myopathic.
6. ʻO ka nui o nā kūlana i kahi e hoʻohālikelike ai ka Rosuvastatin i loko o ke kaila koko he nui e hoʻonui.

I ke koho ʻana iā Rosart, pono e noʻonoʻo pono ka poʻe i nā contraindications i mea e pale ai i ka hoʻomohala ʻana i nā hopena kūpono ʻole mai nā kino ola a me nā ʻōnaehana. ʻO nā hopena ʻaoʻao ka hiʻohiʻona o nā statins a me nā lāʻau āpau e loaʻa ana i ka rosuvastatin ʻaʻole ʻokoʻa.

Nā hopena maikaʻiʻole

• ʻAlaʻi nā wahī a me ka psyche: hōʻeha i ka hopohopo, hopohopo, hopohopo, hōʻeha kaumaha, dizziness, paresthesia, hoʻomohala o ka maʻi asthenic.

• Hoʻopili i nā ʻōnaehana: constipation, pinepine i nā kīwaha, nā ʻōpū o ka ʻōpū, ke keiki ʻūlū, ka naila, ka ʻōpū o ka ʻōpū, ka ʻeka o ka pancreas, hepatitis.
• Metabolism: maʻi hānai.
• Pūnaehana hanu: ranu ihu, pharyngitis, sinusitis huhū, pākaukau, bronchial asthma, ʻeha hanu.
• ʻŌnaehana musculoskeletal: myalgia (ʻehaʻeha o ka ʻōpū), hoʻonui i ke kani o ka ʻōpū, nā ʻāʻī ʻana a me ke ʻeha hoʻi, a me nā hopena o ka pathological.
• Hiki i nā hopena alericue ke piʻi me nā rashes i ke kino, ka hives, ka huehue o ka maka a me ka ʻāʻī, ka hoʻomohala ʻana o ka anaphylaxis.
• ʻO nā hopena ʻē aʻe i makemake ʻia.

Ma ke kānāwai, ke nānā pono ʻia o nā hopena maikaʻi ʻole e pili pono ana i ka dosis o ka lāʻau. Hoʻomaʻamaʻa me nā hoʻoponopono hoʻoponopono hāpau, hoʻoliʻuli a ʻalo loa paha nā hōʻailona.

Eia nō naʻe, me ka hoʻomohala ʻana o nā hōʻailona o kaʻu myopathy a me nā hopena alia, pono ʻoe e kāpae i ka hoʻohana ʻana iā Rosart a ʻimi i ke kōkua olakino.

E kuhikuhi ke kauka i nā kaʻina kūpono a me nā lāʻau lapaʻau e hoʻopau i nā hopena i makemake ʻole ʻia a koho i kahi lāʻau lapaʻau ka mea pono.

Nā hiʻohiʻona o ka lāʻau

Ma ka mākeke lāʻau Lūkini make he nui nā hua lāʻau e loaʻa ana i ka rosuvastatin. Hoʻololi ʻia nā hoʻohālikelike o Rosart e nā ʻo Lūkini a me nā ʻoihana ʻē aʻe. Nui nā lāʻau lapaʻau: Rosucard, Rosulip, Rosuvastain-SZ, Roxer, Rosufast, Rustor, Rosustark, Tevastor, Mertenil. ʻO kēia mau lāʻau āpau ua hoʻohuli ʻia ka kope - generics. ʻO ka lāʻau kanu kumu mua iā Rosuvastatin ʻo Krestor, i hana ʻia ma UK ma Astra Zeneca. ʻO ke kumukūʻai o nā lāʻau lapaʻau e loaʻa ana i ka rosuvastatin ʻokoʻa a hilinaʻi ʻia i ka kumukūʻai mea kākau inoa inoa inoa, dosage a me ka nui o nā papa i loko o ka pākī.

Ke koho nei i ka lāʻau lapaʻau e hoʻohaʻahaʻa i ka cholesterol koko, pono ʻoe e alakaʻi, ʻoi loa i ka ʻōlelo a kāu kauka.

Ke pāpā ʻole nei ia i ke kuhikuhi ʻana i ka mālama statin iā ʻoe iho!

Hiki wale i ke kauka ke koho pololei i ka lāʻau kūpono a me kāna laʻana, i ka ʻike ʻana i nā hōʻike a me nā contraindications. He mea nui ia e hoʻomaopopo i kou kauka i nā lāʻau lapaʻau a pau āu e lawe ai e pale ai i nā hōʻiliʻili lāʻau i makemake ʻole ʻia.

Nā papa lāʻau Rosart: nā loiloi a me nā hōʻike hōʻike no ka hoʻohana

• Mālama i nā pae o ke kō no ka lōʻihi
• Hoʻihoʻi hou i ka hana insulin pancreatic

ʻO kekahi mea koʻikoʻi a koʻikoʻi i ke kino o ke kanaka he cholesterol. He mea nui ia e kūpono ana kāna mau kuhikuhi i ke kuʻuna, ʻoiai ka mea kīnā ʻole a oversupply paha he hopena maikaʻi loa o ke olakino. Ke hoʻonui nei i ka LDL i ke koko e hāʻawi i ka hiʻohiʻona o ka atherosclerosis, ka mea i hōʻailona ʻia e nā loli i ka piʻina o nā kīʻaha koko a me kahi laʻa o kā lākou elasticity.

I kēia manawa, ke kumu no ka pale ʻana o nā ʻano maʻi like ʻole o ka ʻōnaehana cardiovascular i nā lāʻau pili i ka hoʻoponopono ʻana o ka cholesterol metabolism i loko o ke kino o ke kanaka. Ke ola mau nei lākou. ʻO kekahi o nā lāʻau lapaʻau kiʻekiʻe kiʻekiʻe, palekana a palekana hoʻi ka Rosart.

Ma nā hua kūpono, lawe ʻo Rosart i kahi kūlana alakaʻi i waena o ka pūʻulu o nā statins, e hoʻohaʻahaʻa ana i nā hōʻailona o ka "maikaʻi" (lipoproteins haʻahaʻa haʻahaʻa) a hoʻonui i ke kiʻekiʻe o ka "maikaʻi" kolesterol.

No nā statins, ma keʻano, ʻo Rosart, ke ʻano like o nā hana therapeutic e hōʻike nei:

• Mālama i ka hana o nā enzymes e komo i ka synthesis o kolamu i ka hepatocytes. Ma muli o kēia, ua ʻike nui ʻia ka hōʻemi nui ʻana o ka plasma cholesterol.
• Kōkua i ka hōʻemi ʻana i ka LDL i nā mea maʻi e loaʻa i ka hypercholisterinemia hoʻoilina hoʻoilina. He waiwai koʻikoʻi kēia o nā statins, no ka mea ʻaʻole i mālama ʻia kēia maʻi me ka hoʻohana ʻana i nā lāʻau lapaʻau o nā lāʻau lapaʻau ʻē aʻe.
• He hopena maikaʻi kona i ka hana o ka ʻōnaehana cardiovascular, me ka hoʻohaʻahaʻa nuiʻana i nā hōʻeha i nā hoʻopiʻi a me nā ala e pili ana.
• ʻO ka hoʻohanaʻana i kēia lāʻau lapaʻau e alakaʻi i ka emi ʻana o ka nui o ka cholesterol ma mua o 30%, a me LDL - a i ka 50%,
• E hoʻonui i HDL i ka plasma,
• ʻAʻole ia e hoʻonāukiuki i ka nānā ʻana o nā neoplasms a ʻaʻohe i kahi hopena mutagenic i nā kino o nā kino.

Kūʻai Rosart

ʻO ka ʻokoʻa i ka kumukūʻai o ka lāʻau lapaʻau Rosart kolamu ka mea e hilinaʻi i ka manaʻo o ka hana ikaika i loko o lākou (mg) a me ka helu o nā papa iā lākou iho i ka pā.

ʻO ke kumukūʻai o ka Rosart 10 milligrams o 30 mau ʻāpana i kahi pahu e like me 509 mau rubles, akā ke kumu kūʻai o Rosart me ka waihona like o ka mea ikaika, akā he 90 mau ʻāpana i kahi pahu e pālua ʻelua ma kahi kiʻekiʻe - ma kahi o 1190 rubles.

ʻO Rosart 20 mg 90 mau ʻāpana no ka pā kālā he 1,500 rubles.

Oe ke kuai i ka lāʻau lapaʻau ma ka lāʻau lapaʻau ma ka lāʻau lapaʻau. Pono e hoʻomanaʻo ʻia ma mua o ka hoʻomaka ʻana o ka mālama ʻana, pono ʻoe e kipa i kahi loea, hoʻomaʻamaʻa i kahi maʻi holoʻokoʻa a alakaʻi i kahi ola kino e loaʻa ai nā hopena kiʻekiʻe.

Pehea e lawe ai i nā loea statins e haʻi i ka wikiō ma kēia ʻatikala.

• Mālama i nā pae o ke kō no ka lōʻihi
• Hoʻihoʻi hou i ka hana insulin pancreatic

Hoʻopili me nā lāʻau lapaʻau ʻē aʻe

• ʻO ka lāʻau lapaʻau Antacid e hōʻemi i ka kaila o Rosart i ke kahe koko e 35.0%,
• I ka wā e lawe ʻia ai me Digoxin, aia kahiʻino o ka hoʻomohalaʻana i nā pathologies, myopathy a me rhabdomyolysis,
• Nā antibiotics o ka erythromycin a me nā pūʻulu clarithromycin, e hoʻonui i ka plasma o ka lāʻau Rosart i ka hoʻohui ʻana o ke koko plasma,
• I ka mālamaʻana o ka cyclosporin. ʻO ka neʻe o rosuvastatin e piʻi aʻe ma mua o 7 mau manawa,
• Ke hoʻohana nei i ka Rosart a me nā inhibitors, e hoʻonui nui ka manaʻo o ka rosuvastatin, i piha me ka hoʻomohala ʻana i ka myopathy,
• Ke mālama nei me ka warfavir, pono ia e nānā i ka manawa prothrombin,
• ʻO ka lāʻau niacin i hoʻonāukiuki i ka hopena o ka rhabdomyolysis.

Nā manaʻo no ka koho

Hoʻolālā ʻia nā lāʻau lapaʻau Rosart e nā kauka hele wale nō e like me nā hopena o nā mea hana a me nā diagnostics laboratorium.

Ma mua o ka hoʻomaka ʻana i nā ʻano maʻi, pono e hoʻomaopopo ʻia nā maʻi āpau e ke kauka e pili ana i nā hopena maikaʻi ʻole o ka lawe ʻana i ka lāʻau lapaʻau Rosart.

Pono e kau ʻia ka hōʻike nui ma ka hiki ʻana o ka ʻehaʻā o nā ʻuhane a me ke kūkulu ʻana i ka myopathy pathology:

• I ka wā o Rosart e hōʻike ai i kahi poma o 20.0 a me 40.0 milligrams o ka mea hana kaiola ikaika, ka hana o ka indexine phosphokinase index ma ka koko plasma i nānā mau ʻia, me ka hana o nā māla palupalu a me nā pūnao. ʻO ka hoʻonui ʻana i ka hana o ka phosphokinase creatine kahi hōʻailona o ka hoʻomohala ʻana i ka pathology myopathy ma loko o nā uaua uaua. Pono e ʻalo ʻia ka Therapy, a i ʻole ʻia ka ʻōnaehana ʻana ma kahi liʻiliʻi loa,
• Me ka nui o ka hōʻeha ʻana ma nā ʻili o nā uaua a i ʻole nā ​​iwi, pono ka mea maʻi e ʻike i ke kauka. Hoʻomaʻamaʻa pinepine mai ka lawe ʻana i ka lāʻau lapaʻau Rosart, hoʻoulu ʻia ka palupalu o ke kino, a ua kūkulu ʻia nā autoantibodies i loko o lākou,
• Inā i ʻike ʻia ka wahine hāpai i ka manawa hapai i ka manawa o ka hopena o Rosart me ka lāʻau lapaʻau, a laila e pono koke ke kāpae ʻia ka lāʻau lapaʻau, a ʻike ʻia ka wahine hāpai, a pono hoʻi e nānā ʻia ke ʻili.
• Inā hele ʻia kahi overdose o ka lāʻau lapaʻau Rosart, a laila pono ʻoe e kiʻi i kahi kauka. E kaukaʻi ke kauka i ka hana soraticatic; hemodialysis i kahi o kahi overdose o Rosart ʻaʻole ia i hana pono.

Nā kikowaena kūloko

Nā kūmole haole

Hoʻohālikelike

Hoʻohana ʻia ka hoʻohana ʻana i ka lāʻau lapaʻau Rosart e hoʻohaʻahaʻa i ka index kolesterol me ka hoʻonoho ʻana o ka dosis pololei a nā kauka hele mai. Hoʻololi ka hoʻololi ʻana i ka dosage ʻoe iho.

Inā ʻoe e ʻimi i nā ʻōlelo aʻoaʻo a ke kauka a pili i ka meaʻai, a laila hiki iā ʻoe ke wikiwiki i ke kaʻina o ka lāʻau.

Hana ʻia ka hana me ka mālama mau ʻana o ka pōkole kolala.

Vitaliy, 60 makahiki: Ua hala wau i kahi makahiki iā Rosart. E hele maoli nō ʻo Cholesterol i ka maʻamau ma hope o ka lawe ʻana i ka paila no hoʻokahi mahina.

Ua ʻōlelo mai ke kauka iaʻu e lawe i ka lāʻau lapaʻau i ka papa mahele, no ka mea pono iaʻu e mālama maʻamau i kaʻu kolamu.

Ma mua o ka lawe ʻana i ka lāʻau lapaʻau, hele au i ka ʻai hypolipidemic, akā ʻaʻole me ka hoʻohaʻahaʻa ʻana i ka index cholesterol.

ʻO kahi wale nō i koho ʻia ʻo Rosart a me ka meaʻai, hiki iaʻu ke hoʻohaʻahaʻa iho, a i kēia manawa mālama mau i kaʻu kolamu. ʻO nā hopena hopena ka hoʻomaka i ka hoʻomaka o ke aʻo i ke ʻano o ke ʻano hōʻili i ka ʻili o ka ʻili a me nā pilikia o ka pūpū, akā ma hope o 2 mau pule o ka hoʻokele ʻana lākou i hala.

Valentine, 51 makahiki: Ma kahi o ka meaʻai, ua kuhikuhi ke kauka iā Rosart iaʻu ma muli o koʻu kumu momona nui a me ka kolamu kiʻekiʻe (9.0 mmol / L).

No 3 mau lā o ka lawe ʻana i ka lāʻau lapaʻau a me nā meaʻai, ua lanakila wau ma kahi o 12 kilograms, a ua hāʻule ka cholesterol i 6.0 mmol / L.

Ua hauʻoli wau i ka hopena, akā pono e hoʻomau i ka lapaʻau ʻia me nā papa Rosart, a hiki paʻa i koʻu kolamu. ʻAʻole wau i loaʻa i nā hopena ʻaoʻao mai ka lāʻau i ka wā mālama.