ʻO Glurenorm: nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana, nā loiloi, nā analogues

Lapaʻau lāʻau ʻO Glurenorm kahi aelike hypoglycemic oral, kahi derphative sulfonylurea o ka lua o ka hanauna. Hoʻopuka ka Glurenorm i ka mea huna o ka insulin endogenous e ka pancreatic β-cell, hoʻomaikaʻi i ka hoʻohana ʻana i nā glucose, kālai ʻia i ke kaʻina o ka lipolysis.
Hōʻemi ka Glurenorm i ka pale ʻana i ka insulin i loko o ka ate a me nā pā adipose ma o ka hoʻonui ʻana i ka helu o nā ʻāpana o ka insulin a me ka hoʻoulu ʻana i nā kaʻina post-receptor ma muli o ka hana o ka insulin. ʻO ka pono o ka hana hypoglycemic o Glyurenorm ka mea i loaʻa i ka insulin endogenous.
Hoʻomaka ka hopena o ka hoʻohaʻahaʻa i nā pae glucose koko 60-90 mau minuke ma hope o ka lawelawe waha a hiki i ka lōʻihi o 2-3 mau hola ma hope o ka hoʻokele ʻana.
ʻO ka lōʻihi o ka hopena hypoglycemic o Glurenorm he mau hola 8-10. No laila, manaʻo ʻia ʻo Glurenorm he lāʻau pōkole hana pōkole.
ʻO ka hoʻohana ʻana i ka sulfonylureas, kahi mea hana pōkole hana ia, ka mea no ka mālama ʻana i nā mea maʻi me ka nui o ka hopena o ka hypoglycemia, no ka laʻana, ʻo nā mea maʻi maʻi a me nā mea maʻi me ka loaʻa ʻole o ka pilikia.
Ma muli o ka wehe ʻana o ka renal o Glyurenorm i pale ʻole ʻia, hiki ke kuhikuhi ʻia ka lāʻau lapaʻau nui i nā mea maʻi me ka pilikia ʻole a me ka nephropathy maʻi maʻi.
Ua hōʻoia ʻia ka maikaʻi a me ka palekana o ka hoʻohana ʻana o Glyurenorm i nā mea maʻi me ka maʻi mellitus, kahi i hōʻike ʻia no ka hoʻohālikelike ʻana me nā māla sulfonylurea e hoʻohālikelike i nā maʻi ʻeha.
Lapaʻau lāʻau ʻO 2-3 mau hola ma hope o ka nānā ʻana o 30 mg o Glurenorm, ua hōʻea ka nui o ka plasma kiʻekiʻe (500-700 ng / ml), a e piʻi ana me ka hoʻoliʻi ʻana o ka 2 mau hola i ka hola 1 / 2-1. ka lāʻau lapaʻau.
Hoʻopili pū ʻo Glurenorm me nā protein plasma (99%).
Hoʻopili piha ʻia ʻo Glurenorm, ʻo ka mea nui e ka hydroxylation a me ka demethylation. ʻO ka hapa nui o nā metabolites ka hoʻopiʻi ʻia ma o ka system biliary me nā feces. Hoʻokahi wale wahi hapa o nā metabolites i hoʻopili ʻia e nā keiki. ʻIke wale ʻia ʻo 5% o ka pauleʻa e ʻike ʻia i ka molo. Hoʻohana ʻia ma hope o nā ʻōmua helu o Glyrenorm, akā hoʻi ka liʻiliʻi o ka renal excretion.
Eia kekahi, me kahi hoʻokele maʻamau o Glyrenorm i nā poʻe maʻi me ka maʻi mellitus me ka loaʻa ʻole o ka renal, ʻaʻohe hopena i loko o ke ala excretion. ʻAʻohe wahi pilikia o ka hoʻopili o ka mea a i ʻole nā ​​metabolites.
Hoʻokomo ka metabolites i ke koko pharmacodynamically aʻaʻole i hoʻopilikia i nā kiʻekiʻe o ka glucose koko.
Ua hōʻike ʻia nā hoʻokolohua pharmacological i nā kiʻamo a me nā mea isika ua ʻike ʻole ʻia ʻo Glyrenorm a me nā metabolites i hele ʻole mai i ka BBB a i ʻole ka mea maʻi placental.

ʻO ka hoʻohanaʻana i ka lāʻau lapaʻau Glyurenorm

Hoʻomaka hoʻomaʻamaʻa mua
ʻO ka maʻamau, ʻo ka pākaukau mua o Glenrenorm ʻo 1/2 papa (15 mg). Lawe ʻia ia i ka wā kakahiaka kakahiaka. Me ka hanaʻole, hiki ke hoʻonui mālie i ke ʻano. Hāʻawi ʻia, ʻaʻole eʻoi aku ma mua o 2 mau papa (60 mg), hiki i nā lā maʻamau o Glyurenorm ke loaʻa hoʻokahi manawa i ka wā kakahiaka. Eia nō naʻe, i ka hoʻohana ʻana i nā ʻoi aku ʻoi loa, hāʻawi ʻia ka mana maikaʻi loa e ka manawa 2-3 i kēlā me kēia lā. I kēia hihia, pono ke kiʻi ʻia ka nui loa ma ka ʻaina kakahiaka. Pono e lawe ʻia nā papa Glenrenorm ma ka hoʻomaka ʻana o ka ʻaina. Pono e hāpai i ka hoʻonui ʻana i ka pā ma nā papa 4 (120 mg) i kēlā me kēia lā maʻamau ʻaʻole alakaʻi i ka hoʻonui hou i ka hopena therapeutic.
Ke hoʻopili nei i kahi mea maʻi wahaʻaka hypoglycemic like me kahi hana like o ka hana
Hoʻoholo ʻia ka ʻanā mua ma muli o ka papa o ka maʻi i ka manawa hoʻokele o ka lāʻau lapaʻau. Ke hoʻololi nei i kahi lawena antidiabetic hou me Glurenorm, e hoʻomanaʻo ʻia he mea like me ka hana o 1 papa o Glurenorm ma waena o 1000 mg o tolbutamide.
Hoʻohui hui
Inā hāʻawi ʻole ʻo monotherapy me Glurenorm i ka nui o ka mālama ʻana i nā pae glucose o ke koko, pono e noʻonoʻo pono ʻia ka koho o ka biguanide.
ʻO ka lōʻihi o ke kauʻana o ke keʻena e pili ana i ke ʻano o ka maʻi a me ka pono o ka hoʻomohala ʻana.

Nā maʻi hoʻohālikelike i ka hoʻohana ʻana i ka lāʻau Glurenorm

Insulin-depend type I diabetes mellitus, diabetic coma and precomatosis, diabetes mellitus paʻakikī e ka acidosis a me ka ketosis, ma hope o ka maʻi pancreatic, ma ke ʻano o ka maʻi hopohopo, ma mua o ka hōʻoki ʻana, ka hana hōʻeha kaumaha, ʻeha kūmole (hepatic) porphyria, hypersensitivity i Hoʻomākaukau kaʻaila.

Nā hopena ʻaoʻao o ka lāʻau lapaʻau Glenrenorm

Ma ke ʻano, he mālama maikaʻi ʻia ʻo Glurenorm e ka poʻe maʻi, akā ma kekahi mau mea e kū ai ka hopena hypoglycemic, nausea, luaʻi, constipation, ʻeha, hoʻonaninau, ʻano kūlohelohe: ʻeha, ʻehaʻeha, hōʻeha, kuʻi, nā huakaʻi o ka noho ʻana, thrombocytopenia hiki mai.
I kekahi mau hihia, ulu i ka cholestasis intrahepatic, urticaria, Stevens-Johnson syndrome, leukopenia, agranulocytosis i ulu.

ʻO nā ʻōlelo kūikawā no ka hoʻohana ʻana i ka lāʻau Glurenorm

ʻO ka wā hāpai a me ka lactation. ʻAʻole i hana ʻia nā haʻawina o ka hoʻohana ʻana iā Glyurenorm i ka wā hāpai a me ka lactation. No laila, pono e pale ʻia ka hoʻohana ʻana o Glurenorm i kēia manawa. Inā hoʻokumu ʻia ka hapai, pono e hoʻōki i ka lawe ʻana iā Glyurenorm i ka wā hiki.
I ka mālamaʻana i ka maʻi maʻi, pono ka mālama mālama maʻi maʻamau. Pono e mālama pono i ka wā koho a i ʻole nā ​​mea hoʻohana i ke kala ʻana.
ʻOiai ʻo 5% wale nō o Glurenorm e hoʻopili ʻia e nā keiki a maʻa pinepine lākou i ka maʻi o nā maʻi me ka maʻi ʻōpū, ʻo ka mālama ʻana i nā mea maʻi me ka hōʻeha o ka renal nui e hana ʻia ma lalo o ka mākaʻi mālama olakino.
ʻO nā maʻi me ka maʻi maʻi e pili ana i ka hoʻomohala ʻana o nā maʻi cardiovascular. Hiki ke hoʻemi ʻia kēia pilikia ma ka hahai pololei ʻana i ka meaʻai i kau ʻia e ke kauka. ʻAʻole pono e hoʻohana i nā ʻoihana antidiabetic waha e hoʻopili i kahi meaʻai therapeutic e hiki ai iā ʻoe ke hoʻomalu i ke kaumaha o ke kino o ka mea maʻi a mandatory inā ʻaʻole e hoʻohana ʻia ka lāʻau hypoglycemic. ʻO nā mea āpau āpau antidiabetic waha me kahi kīʻaha kūpono ʻole a i ʻole hoʻonāukiuki i ka regimen dosis i hoʻākāka ʻia hiki ke piʻi i ka nui o ke kaʻe o ka glucose koko. ʻO ka hoʻohana ʻana i ke kō, nā momona, a i ʻole nā ​​mea inu ʻaina e kōkua i ke kū ʻana i kahi kūlana hypoglycemic hoʻomaka.
Hoʻokomo i ka hiki ke alakaʻi i nā kaʻa a hana a me nā mīkini ʻē aʻe.Pono e hōʻike ʻia nā mea maʻi e pili ana i ka mālama ʻana i nā hana e pale ai i ka hypoglycemia i ka wā e holo ana. He mea koʻikoʻi kēia no nā mea ʻaʻole i loaʻa nā hōʻailona o ka hypoglycemia a hoʻomaopopo paha i nā manawa pinepine o hypoglycemia. ʻO ke kūpono o ke kaʻa e pono e noʻonoʻo i ka māmā o kēia mau kūlana.

Nā hopena lapaʻau lāʻau Glurenorm

Pono e hoʻohui ʻia nā pilina me nā lāʻau lapaʻau e pili ana i ka metabolism glucose.
ʻO nā lāʻau lapaʻau e hiki ai ke hoʻonui i ka hopena hypoglycemic of Glurenorm: NSAIDs, MAO inhibitors, oxytetracyclines, ACE inhibitors, clofibrates, cyclophosphamides and derivatives, sulfonamides and other antibiotics that inhibit excretion, other drug antidiabetic, insulin.
ʻO nā lāʻau lapaʻau e manaʻo pono ai e hoʻonui i ka hopena hypoglycemic o Glurenorm: β-adrenergic blocker blockers, other sympatholytics (e.g. clonidine), reserpine, guanethidine. Hiki i kēia mau mea ke hoʻopili i nā hōʻailona o ka hypoglycemia.
ʻO nā lāʻau lapaʻau e hiki ai ke hōʻemi i ka hopena hypoglycemic o Glurenorm: GCS, contraceptives steroid, sympathomimetics, thyroid hormones, glucagon, diuretics (thiazide type or loop diuretics), diazoxide, fenothiazine, nicotinic acid.
ʻO Barbiturates, rifampicin, phenytoin a me nā mea like like paha e hoʻemi i ka hōʻeha o ka hopena hypoglycemic o Glyrenorm ma o ka hoʻoulu ʻana i nā aʻoma o ka huina.
ʻO ka hōʻemi ʻana a hoʻonui paha i ka paʻakikī o ka hopena hypoglycemic of Glurenorm i hoʻomaopopo ʻia me ka hoʻohana pū ʻana me nā Hagon receptor H2 (cimetidine, ranitidine) a me nā waiʻona.

E hoʻokuʻu i ke ʻano a me ka ʻano

ʻO nā papa hua ʻōlelo o Glyurenorm he papa: pōkā, pōʻai, keʻokeʻo, me nā kihi beveled, ma kekahi ʻaoʻao aia i kahi kālai ʻana o ka hōʻailona ʻana i ka hui, ma kēlā ʻaoʻao kēia hanana pōpilikia, ma nā ʻaoʻao ʻelua he kiʻi ʻalaʻi "57C" (10 pcs. In blisters, 3, 6 or or 12 kaʻaila i kahi kāwele o ke kāleka).

ʻO ka papa kai ola: glycidone, ma 1 papa - 30 mg.

Nā kumuwaiwai hou: hoʻoiho pāpaʻi palaoa, hoʻomaloʻo kīlea, magnesium stearate, lactose monohala.

Lapaʻau lāʻau

Hoʻonui ka Glycvidone i ka synthesis o ka insulin ma o ke kāohi ʻana i kahi ala glucose-mediated no ka hoʻokumu ʻana o kēia ʻano. Ua hōʻike ʻia nā hoʻokolohua holoholona me ka mālama ʻana i ka lāʻau i ka pale ʻana i ka insulin i ka kiko adipose a me ka hoʻonaninani kino i ka hoʻonui ʻana i ka pilina o nā mea ʻae o ka insulin, me ka hoʻoulu ʻana i ka hana post-receptor i hoʻokumu ʻia e ka insulin. Hoʻokumu ka hopena hypoglycemic i ka 1-1.5 mau hola ma hope o ka hoʻokele waha. Ua hoʻopaʻa ʻia ka hopena nui loa i nā hola 2-3 ma hope o ka hoʻokele ʻana a lōʻihi i nā hola 8-10. ʻO Glycvidone kahi hana pōkole o ka sulfonylurea hana pōkole, ka mea e hoʻohana ai i kāna hoʻohana ʻana i nā mea maʻi me ka maʻi diabetes mellitus type 2 me kahi hopena kiʻekiʻe o ka hypoglycemia, no ka laʻana, i nā mea maʻi ma nā mea maʻi a i nā mea maʻi me nā hana o ka renal.

No ka mea ke hoʻopili ʻia nei ka glycidone ma o nā keiki i nā mea liʻiliʻi, hiki ke kuhikuhi ʻia i ka lāʻau lapaʻau no nā mea maʻi me ka nephropathy maʻi pākuʻi a me ka hana hana ʻole. Aia he hōʻike no ka lawe ʻana iā Glenrenorm i nā mea maʻi me ka maʻi diabetes mellitus type 2, e loaʻa ana i nā maʻi ʻeha concomitant, maikaʻi loa a palekana. Eia naʻe, ke hoʻopau ʻia ka ulu ʻana o ka mea hana i loko o nā mea maʻi. I kēia hihia, ʻaʻole ʻōlelo ʻia ka koho ʻana o ka glycidone i nā mea maʻi me ka maʻi mellitus maʻi paʻakikī e nā maʻi hepa hepatiko.

Hōʻike nā hualoaʻa o nā noiʻi maʻi ma ka hoʻohana ʻana iā Glyurenorm no 18 a me 30 mau mahina ʻaʻole e hoʻonui i ka paona kino, a ma kekahi mau manawa aia ke emi o ka paona kino ma loko o 1-2 kg. Hoʻohālikelike nā haʻawina hoʻohālikelike i nā haʻawina ʻikepili a me ka loaʻa ʻole o nā loli nui i ke kaumaha o ke kino i nā mea maʻi e lawe nei i ka glycidone.

Lapaʻau lāʻau

Me kahi helu hoʻokahi o ka glycidone ma kahi o 15 a 30 paha mg, hoʻihoʻi ʻia ka waiwai mai ka wahi o ke kūwaho ʻana me ka wikiwiki nui a kokoke loa (80-95%). ʻO ka pae kiʻekiʻe loa i ka plasma koko ma ka awelika 0.65 μg / ml (i hoʻololi i ka awelika mai 0.12 a 2.14 /g / ml) a ua hōʻea i kahi o 2 mau hola 15 mau minuke (fluctuations ma ka pae o 1.25‒4.75 hola). ʻO ka wahi ma lalo o ka pihi paʻa-manawa (AUC) he 5.1 μg × h / ml (hiki i nā fluctuation ma waena o 1,5 a 10.1 μg × h / ml) paha.

ʻAʻohe ʻokoʻa nā hiʻohiʻona o ka pākuʻi pharmacokinetic ma waena o nā mea olakino a me nā mea maʻi me ka maʻi mellitus.

Hōʻike ʻia ʻo Glycvidone e kahi kiʻekiʻe loulou no nā protein plasma iʻoi aku ma mua o 99%. ʻIke ʻia ka ʻike ma ka ulu ʻana o kekahi mea a i ʻole kāna mau metabolites ma o ke kahe koko-a me ka paa o ka placental. ʻAʻohe mau mea i ʻike i ka glycidone aia i loko o ka waiū umauma.

Hoʻopili piha ʻia ʻo Glycvidone i loko o ka ate, ʻo ka mea ma o ka demethylation a me ka hydroxylation. ʻO nā metabolites Glycvidone he mau lāʻau lapaʻau i hana ʻole ʻia, a e hōʻike iki ana i kahi hana i hoʻohālikelike ʻia i ka pūnaehana makua.

Hoʻopili ʻia nā metabolito Glycvidone me nā feces, a he wahi liʻiliʻi wale nō o lākou i hoʻonui ʻia i ka urine. Ua hōʻike ʻia nā hopena noiʻi ma hope o ka hoʻopale ʻana i ka waha, ma kahi o 86% o ka radiolabelled (14 C) glycidone e hoʻopio ʻia ma o ka ʻōpū. ʻO kahi 5% (i ka ʻano o nā metabolites) o ka nui i lawe ʻia ka mea e hoʻopili ʻia ma o nā ʻōpū, a ʻaʻole kēia hilinaʻi i ka ʻōhua a ʻaʻole hilinaʻi i ke ala o ka hoʻokele ʻana o Glyurenorm. ʻOiai me ka hoʻohana maʻamau ʻana i ka lāʻau, ua excreted i ka urine i ka liʻiliʻi liʻiliʻi.

ʻO ka hapalua hapa-ola ʻo 1.2 mau hola (ʻo ka nui o ka ʻano he 0.4-3 hola), a me ka hapalua o ka hapalua he ola he 8 mau hola (hiki ke ʻano ka nui o ka waiwai mai ka 5.7 a i ʻole ka 9.4 mau hola).

I nā poʻe maʻi o ka wā kiʻekiʻe a me ka makahiki waena, ua like nā ʻila like me nā lāʻau lapaʻau me kekahi. I nā mea maʻi me nā maʻi o ka maʻi a me nā maʻi hepatic, ua hoʻopili ʻia ka hapa o ka glycvidone. Aia ma laila ke hōʻike nei ka pau ʻana o ka metabolism o ka hana ikaika o ka lāʻau lapaʻau e hoʻololi mau nei i nā mea maʻi me ka nele o ka ate. No ka mea ke hoʻopiʻi ʻia nei ka glycidone ma o nā keiki i nā mea liʻiliʻi, ʻaʻohe ʻōmole o ka lāʻau lapaʻau i nā mea maʻi me ka maʻi papalē.

Nā ʻōkuhi no ka hoʻohana ʻana iā Glyurenorm: ke ʻano a me ka helu ʻana

Kuhi ʻia ka Glurenorm e like me nā ʻōlelo a ke kauka e pili ana i ka nui o ka ʻaʻai a me ka meaʻai.

I ka hoʻomaka ʻana o ka pena ʻana, e like me ke kānāwai, ua ʻōlelo ʻia nā papa ½ i ka wā o ka ʻaina kakahiaka (ma ka hoʻomaka ʻana o kahi pāʻina). Inā ʻaʻole i hoʻomaikaʻi ʻia ka hoʻomaikaʻi, hoʻonui ʻia ka pāoʻi.

Inā ʻaʻoleʻoi aku ka lāʻau maʻamau i kēlā me kēia lā, pono e lawe i ka wai kakahiaka 1. Inā keu aʻe, pono ia e hoʻokaʻawale ma ka 2-3 dosis, akā e lawe i ka hapa nui loa i ke kakahiaka i ka kakahiaka kakahiaka.

ʻO ka papa helu ʻokoʻa loa i kēlā me kēia lā he 4 papa. ʻO ka hoʻonui ʻana i ka mahele o nā papa he 4 ʻoi aku ka maikaʻi, no ka mea ʻaʻole ia e alakaʻi i kahi mahuahua.

Mai hoʻokaʻawale i kahi ʻai ma hope o ka lawe ʻana iā Glyurenorm a kāpae i ka lāʻau lapaʻau me ke ʻole e kūkā me ke kauka.

Ke koho ʻana i ka lāʻau lapaʻau ma loko o kahi hapa o ka nui o ka 75 mg (2.5 mau papa), nā mea maʻi me ka hana maʻi lēwa ʻole ʻia e pono e kiaʻi pono ai i ke kūlana.

I ka hihia o ka hopena o ka hopena i ka wā o ka monotherapy me Glyrenorm, hiki ke kuhikuhi i ka hui pū ʻana me ka metformin.

Nā hopena hopena

• Hematopoietic ʻōnaehana: leukopenia, thrombocytopenia, agranulocytosis,
• Pūnaehana maʻi: luhiluhi, vertigo, paresthesia, hōʻea i ka ʻōpū, ʻāwīwī,
• Pūnaehana Cardiovascular: extrasystole, hypotension, angina pectoris, cardiovascular gagal,
• Pūnaehana Digestive: nausea, nalowale i ka makemake, waha maloʻo, ʻūhā ma ka ʻōpū, constipation / diarrhea, hoʻoheheʻe ʻia, cholestasis,
• Metabolism: hypoglycemia,
• Pūnaewele o ka hihiʻo: nā wahi noho hoʻomaha,
• ʻO ka ʻili a me ke kikoʻīiwi kikoʻī: ke ʻano o ka photosensitivity, urticaria, ʻehala, ʻeha, Stevens-Johnson syndrome,
• Nā ʻokoʻa: ʻehaʻeha.

Ke keu

ʻO ka overdose o Glyurenorm ka mea e hoʻonāukiuki i ka hypoglycemia, ka mea i hoʻoholo ʻia e kēia mau hōʻailona: nā hopohopo motor, tachycardia, palpitations, ʻōlelo a me ka pohō, nā huhū nui, ka pōloli, ka huhū, ka insomnia, ka ʻeha, ka haʻalulu, a me ka maʻule. Ke hele mai nā hōʻailona o ka hypoglycemia, pono e ʻai i ka meaʻai i nā momona momona a i ʻole glucose (dextrose).Ma ka hihia o ka hypoglycemia koʻikoʻi, i hele pū me ka nalowale o ka ʻike a coma paha, mālama ʻia ka dextrose. Ma hope o ka ʻike hou ʻana i ka mea maʻi, pono ʻo ia e lawe maʻalahi i ka hoʻoweliweli o ka hōʻawaʻawa i mea e pale ai i ka hoʻoulu ʻana.

ʻŌpū a me ka lactation

ʻAʻole ʻike ka ʻike e pili ana i ka hoʻohana ʻana i ka glycidone i nā mea maʻi i ka wā hāpai a me ka lactation. ʻO nā wahine hāpai i hāpai ʻia me ka maʻi maʻi e pono ka mālama mau ʻana i nā ʻike glucose glucose. ʻO ka lawe ʻana i nā lāʻau lapaʻau hypoglycemic waha i nā maʻi i ka wā hāpai, ʻaʻole ia e hōʻoia i ka kontrol glycemic pono. No kēia kumu, lawe aku iā Glyurenorm i ka wā hapai ua contraindicated.

Inā ua lilo ka mea maʻi i ka wā o ka mālama ʻana me ka lāʻau lapaʻau, a nāna e hoʻolālā iā ia, ua kāpae ʻia ka glycidone a hoʻololi ʻia i ka insulin.

Me ka hana pūpū hemahema

ʻAʻole ʻōlelo ʻia o Glurenorm no nā maʻi me nā maʻi neʻe palaki koʻikoʻi, no ka mea, he 95% o ka nui i lawe ʻia e kālai ʻia i loko o ka ate a hoʻoulu ʻia me nā feces. Nā haʻawina haukaʻi i loaʻa i nā maʻi me ka maʻi mellitus me nā palaka o nā ʻano like ʻole (me ka cirrhosis o ke ake o ka ʻōpū, i hui pū ʻia me ka hypertension portal) i hana i hōʻike ʻia, ʻaʻole i alakaʻi ka glycvidone i ka pale hou i ka hana o ka ate, ka nui o ka hōʻeha ʻana i nā hopena o ka hopena, a me nā hopena hypoglycemic. ua nele.

Hoʻohui nūhou

Hiki ke hoʻonui i ka hopena hypoglycemic o Glurenorm me ka hoʻomohala like ʻana o nā lāʻau lapaʻau e pili ana: ka monoamine oxidase inhibitors, non-steroidal anti-inflammatory drug, analgesics, antifungal agents, tricyclic antidepressants, tetracyclines, insulin, other drug hypoglycemic drug, angiotensin-cycloformin-converging enzyme , sulfonamides, sulfinpyrazone, clofibrate, clarithromycin, chloramphenicol, allopurinol.

ʻO Sympatholytics (me ka clonidine), nā beta-blockers, ke guanethidine a me ka reserpine hiki ke hoʻonui wale i ka hopena hypoglycemic o Glyrenorm, akā i ka manawa like i hoʻopilolilo i nā hōʻailona o ka hypoglycemia.

Hiki ke hoʻemi i ka hopena hypoglycemic o Glyurenorm i ke kauoha ʻana i nā lāʻau lapaʻau e pili ana i ka hopena: sympathomimetics, glucocorticosteroids, hormone thyroid, thiazide a me ka diuretics, oral contraceptives, hoʻomākaukau o ka nikotinic acid, aminoglutetimide, phenothiazine, diazoxide, glucagon, rifenitin a me nā rifenitin.

Me ka hoʻohana like o ka ethanol, histamine H blockers₂-leceptors (no ka laʻana, ranitidine, cimetidine), hiki i ka mea ke hoʻoikaika a hoʻonāwaliwali i ka hopena hypoglycemic o Glyurenorm.

Nā mea hoʻohālikelike o Glurenorm: Amix, Glair, Glianov, Glibetic, Gliklada.

Ka hoʻonohonoho ʻana a me ke ʻano o ka hoʻokuʻu ʻana

Loaʻa ka Glurenorm i ke ʻano o nā papa, ke keʻokeʻo a puni me ka hōʻailona "57C" a me ka hōʻailona o ka ʻoihana ma ka kua. Aia kēlā me kēia papa i ka 30 mg o ka waiwai ikaika - glycidone, nā mea kōkua e hāʻawi ʻia i loko o ke ʻano o: ka lactose monohydrate, soluble starch palaoa, maloʻo, magnesium stearate. Hoʻopili ʻia nā papa i 10 mau ʻāpana. i nā pōpō i kālai ʻia i nā pahu kāleka o 3, 6 a i ʻole 12 mau pcs.

ʻLoe a me ke kākele

Lawe ʻia nā papa ʻelua. ʻO ka hoʻoponopono o ka lawe ʻana iā Glenrenorm a me ka helu o ka lāʻau lapaʻau, e hoʻoholo pono ana ma ke kumu o ka hana paʻakai akea.

ʻO ka maʻamau, ʻo ka hapalua mua o ka lāʻau he hapalua ia o kahi papa ʻaina, ua manaʻo ʻia e lawe i ka ʻaina kakahiaka. Eia kekahi, inā pono, e hoʻonui mālie ka nui (e like me nā ʻōlelo a ke kauka).

I kahi hihia e kuhikuhi ʻia ai ka mea maʻi i nā papa he 2 i kēlā me kēia lā, hiki ke lawe ʻia i ka pā hoʻokahi. ʻO nā helu kiʻekiʻe o Glenrenorm e pono e hoʻokaʻawale i ʻelua a ʻekolu paha mau helu.

Nā kuleana a me nā kūlana e waiho ai

E like me nā kuhikuhi, e mālama ʻo Glurenorm i kahi wahi pōʻeleʻele, maloʻo a i waho o ka hiki o nā keiki.

Mai nā lāʻau lapaʻau, hāʻawi ʻia ka lāʻau lapaʻau ma ka lāʻau lapaʻau. ʻO ke ola ʻelima o nā papa, i lalo o nā manaʻo o ka mea hana hana, ʻelima mau makahiki. ʻAʻole hiki ke hoʻohana ʻia Glurenorm ma hope o ka lā pau.

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Ka hana lāʻau lapaʻau

Hoʻopuka ka Glurenorm i ka hopena pancreatic a me ka extrapancreatic hopena, e kōkua i ka hoʻoulu ʻana i ka mea huna o ka insulin endogenous (ka mea koʻikoʻi o nā pakanā ka lolo) e nā ʻāpana beta pancreatic, ʻoiai e hoʻonui ana i ka hana o ka insulin, e pili ana i ka piʻi o ka glucose e nā ʻāʻī a me ka puʻuwai, a pale ʻia i ka lipolysis i loko o ka pili adipose. Hoʻomaka ka ulu ʻana o ka glucose i ke koko e hoʻokaʻawale i hoʻokahi hola ma hope o ka lawe ʻana i ka lāʻau lapaʻau, hiki i ka hopena kiʻekiʻe ke loaʻa ma hope o nā hola 2-3, ʻo ka lōʻihi o ka hana a Glenrenorm e like me nā loiloi he 8-10 mau hola. Hoʻopau piha ka Glurenorm mai ka hana a kaʻi ʻana, metabolized i loko o ke aʻa a hoʻoulu ʻia ka nui ma o nā ʻōpū a me ka 5% wale nō i loko o ka urine.

ʻO Glurenorm, ka mea he derphative sulfonylurea, he lāʻau lapaʻau pōkole loa, no laila ke noi ʻia nei e hoʻohana ʻia nā poʻe maʻi e hōʻeha ʻia i ka maʻi type 2 me ka hopena kiʻekiʻe o ka maʻi hypoglycemia (pākēlau a i ʻole me ka hana pūnāwai hemahema). Eia kekahi, hiki ke hoʻohana ʻia ka lāʻau lapaʻau i nā mea maʻi me ka nephropathy diabetes a me ka maikaʻi ʻole o ka renal, no ka mea ua hoʻopau ʻia ka glycidone e nā keiki i ka liʻiliʻi.

Contenations Glenrenorm

E like me nā kuhikuhi i hoʻopili ʻia iā Glurenorm, ua contraindicated ke hoʻohana ʻana i ka lāʻau i:

• ʻO kaʻeha hōʻeha o ka naʻau,
• ʻAno maʻi type 1
• ʻO ke kūleʻa diabetes and precomatous kahimtang,
• Nā makahiki ma hope o ka pale ʻana o ka pancreatic,
• Nā maʻi maʻi maʻi
• ʻO ka hāpai ʻana a me ka wā o ka umauma,
• ʻO ka hoʻokō ʻana me nā maʻi insulin e pono ai,
• ʻO Galactosemia, ka nele o ka lactase,
• Ma lalo o nā makahiki 18,
• Hypersensitivity i ka lāʻau lapaʻau.

Eia kekahi, me ka makaʻala nui, hāʻawi ʻia ka lāʻau lapaʻau i nā mea maʻi me ka hana thyroid impaired, me ka febrile syndrome, a ke loaʻa pū nei hoʻi me ka inu ʻalowa.

ʻO ka hoʻonohonohoʻana o nā lāʻau lapaʻau, kāna wehewehe ʻana, ke kīʻaha ʻana, ʻano

Ma ka ʻano hea e hana ai ka hoʻomākaukau ʻana o ka Glurenorm? Hoʻomaopopo nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana i kēia huahana ma ke ʻano o nā papa keʻokeʻo a me ke one o ke ʻano pōʻai ʻole, me kahi noʻoki a me nā kihi, a me ke kahakaha "57C" a me ka hōʻailona o ka hui.

ʻO ka māhele nui o ka lāʻau lapaʻau i nīnau ʻia he glycidone. Hele pū kekahi i ka pauka palaoa, lactose monohidate, soluble pākaʻi a me ka magnesium stearate (hoʻohui pū).

Ke hele nei ka lāʻau Glurenorm (mau papa) i ke kūʻai ʻana ma nā poli o nā ʻāpana he 10, kahi i kāhi ʻia i nā kāleka kāleka.

Ka hana lāʻau lapaʻau

He aha ka lāʻau lapaʻau Glurenorm? ʻO ka ʻōlelo aʻo no ka hoʻohana ʻana i nā hōʻike pili, he haehae hypoglycemic kēia, he derivative o ka sulfonylurea (he lua o ka hanauna). Loaʻa ia no ka hoʻokele waha wale nō.

ʻO ka lāʻau lapaʻau i ka nīnau he extrapancreatic a me nā hopena pancreatic. Hoʻonohonoho ia i ka mea huna o ka insulin a me ka potentiates ke kūpaʻa glucose-mediated o kona kūkulu.

Ua hōʻike ʻia nā hoʻokolohua lāʻau holoholona holoholona me ka lāʻau lapaʻau Glyurenorm, nona ka ʻōlelo aʻo i loko o kahi pahu pahu, hiki ke hoʻemi i ka pale ʻana i ka insulin i ka iwi adipose a me ka puʻuwai. Hana ʻia kēia ma o ka hoʻoulu ʻana o ka hana postreceptor, i hōʻiliʻili ʻia e ka insulin, a me kahi piʻi ʻana o kona mau mea hānai.

Hoʻopilikia ka hopena hypoglycemic ma hope o ka lawe ʻana i ka lāʻau ma hope o 65-95 mau minuke. ʻOiai no ka hopena kiʻekiʻe o ka lāʻau lapaʻau, loaʻa ma hope o nā hola 2-3 a lōʻihi i ka hola 8-10.

ʻO nā waiwai Kinetic

Ke ʻōlelo nei ke kuhikuhi no ka hoʻohana ʻana o "Glyurenorm" i ka hoʻohana ʻana i hoʻokahi maʻa o kēia lāʻau lapaʻau (15-30 mg) e kōkua ana i kona wikiwiki a piha pono ʻana mai ka gastrointestinal tract (e pili ana i ka 80-95%). Ua hiki ʻo ia i ka piko o kona manaʻo ma hope o 2 mau hola.

ʻO ka mea ikaika o ka lāʻau lapaʻau he pilina kiʻekiʻe no nā protein plasma.

ʻAʻohe ʻikepili i ka hiki ʻana o ka glycidon a i ʻole nā ​​mea e hoʻopiʻi ma o ka placenta a i ʻole BBB. Aia kekahi ʻikepili i ka pā ʻana o ka glycidone i ka waiū umauma.

ʻAuhea ka metabolism o ka lāʻau lapaʻau "Glyurenorm"? Ke ʻōlelo nei ka hoʻohana ʻana i ka lāʻau o ka nīnau i loko o ke akea ma o ka demethylation a me ka hydroxylation.

ʻO ka ʻōpū o ka derivatives o glycidone i hoʻopili ʻia ma o nā ʻōpū. ʻO ka hapalua ola o kēia lāʻau lapaʻau he 1-2 hola.

I nā poʻe maʻi a me nā waena waena, ua like nā ʻāpana kinetic o Glyurenorm.

Wahi a nā poʻe loea, ʻaʻole loli ka metabolism o kēia lāʻau lapaʻau i nā mea maʻi me ka maikaʻi ʻole o ka ate. Pono nō hoʻi he mau mea i loko o nā mea maʻi me ka hana pūpū maʻi lēwa ʻole, ʻaʻole e hōʻiliʻili ka lāʻau.

Aia ma lalo o ke ʻano ka hopena o ka lāʻau lapaʻau "Glurenorm"? Nānā nā ʻōlelo e hoʻohana ai, nā loiloi e hōʻike ʻia ana ka mākaʻi no kona hoʻohana ʻana i ke ʻano o ka maʻi diabetes mellitus type 2 i ka poʻe ʻelemakule a me waena.

Kūʻai no ka lawe ʻana i ka lāʻau lapaʻau

I nā hihia hea ke kuhihewa nei e kuhikuhi i nā papa Glurenorm? Ke hōʻike nei ke kuhikuhi i ka hoʻohana ʻana i nā contraindications e pili ana i kēia lāʻau lapaʻau.

• kahapula
• maʻi diabetes type 1
• uhaiki ikaika
• hoʻonaninani maʻi, precoma, ketoacidosis a me ka coma,
• ka manawa ma hope o ka haʻalele ʻana o ka pancreas,
• nā maʻi hoʻohemo maʻamau e like me ka galactosemia, ka lactose intolerance, ka nele o ka lactase a me ka malabsorption glucose-galactose,
• nā hana maʻamau o ka mea maʻi (no ka laʻana, ka hōʻeha kino, nā maʻi maʻi maʻi),
• wā hāpai
• makahiki liʻiliʻi (ma muli o ka lawa ʻole o ka ʻike i ka palekana a me ka hana o ka lāʻau lapaʻau i kēia ʻōpio makahiki).
• umauma umauma
• hypersensitivity a sulfonamides

Keʻano lāʻau "Glurenorm": ʻōkuhi no ka hoʻohana

Hoʻolālā wale ʻia nā papa glurenorm i loko. Ke lawe nei lākou, pono ʻoe e hahai i nā ʻōlelo a pau a ke kauka e pili ana i ka nui o ka lāʻau a me ka meaʻai. Hāʻawi ʻo ia i ka hana ʻana i ka lāʻau lapaʻau me ka ʻole o ka kūkā mua ʻana me ka loea.

ʻO ka paʻu mua o ka lāʻau lapaʻau i nīnau ʻia he 0.5 mau papa (i.e. 15 mg) i ka wā kakahiaka kakahiaka mua. E lawe ʻia ka lāʻau lapaʻau i ka hoʻomaka ʻana o ka ʻai. Ma hope o ka ʻai ʻana, pāpā ʻia ka ʻai ʻana.

Inā ʻaʻole e hoʻohana ka papa ʻaina 1/2 i ka holomua, a laila ma hope o ka nīnau ʻana i ke kauka, e hoʻonui mālie ka dosage. Me kahi maʻi o kēlā me kēia lā o "Glyurenorm" ʻaʻole iʻoi aku ma mua o 2 papa, hiki ke loaʻa i hoʻokahi manawa i ka wā kakahiaka.

Inā ua kau ʻia e ke kauka i nā kiʻekiʻe kiʻekiʻe o ka lāʻau lapaʻau, a laila no ka hopena maikaʻi loa e hoʻokaʻawale ʻia lākou i 2 a i 3 mau dosis.

ʻO ka hoʻonui ʻana i nā kao o kaʻoi aku o 4 mau papa i ka lā maʻamau ʻaʻole e hoʻonui i ko lākou pono. No laila, lawe aku i ka lāʻau lapaʻau "Glyurenorm" i ka nui o ka nui i ʻōlelo ʻia ʻole.

I nā poʻe me ka hana renal impaired, ʻaʻole pono ka hoʻoponopono ʻana.

ʻO ka lawe ʻana i ka lāʻau lapaʻau ma luna o 75 mg i nā mea maʻi me ka hana aho lēʻaleʻa e pono ai ka mālama pinepine ʻana e ke kauka.

I ka hihia o ka hopena therapeutic hopena, a me "Glurenorm" hiki i ka mea maʻi ke kuhikuhi hou ʻia i "Metformin".

Nā hihia keu

ʻO ka lawe pinepine ʻana i nā papa kiʻekiʻe o nā derivatives sulfonylurea e alakaʻi pinepine ai i ka hypoglycemia. Eia kekahi, hiki i kahi overdose o kēia lāʻau lapaʻau ke hopena i nā hōʻailona ma lalo iho: hoʻoheheʻe, tachycardia, irritability, pōloli, hōʻeha, palpitations, haʻalulu, insomnia, hopohopo hopohopo ,ʻike makaʻo a me ka haʻi'ōlelo, nalowale ka ʻike.

Ke hele mai nā hōʻailona o ka hypoglycemia, pono ʻoe e lawe i ka glucose a ʻai paha i nā momona.

Nā hopena hopena

I kēia manawa ʻike ʻoe i ke kumu o ka lāʻau lapaʻau e like me Glurenorm i kauoha ʻia. Ua hōʻike ʻia hoʻi nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana i kēia lāʻau lapaʻau ma luna.

Wahi a nā mea maʻi, ʻoiai e lawe ana i kēia lāʻau, hiki iā ʻoe ke ʻike:

• thrombocytopenia, angina pectoris, agranulocytosis,
• paresthesia, hypoglycemia, mahā,
• leukopenia, ʻumi, uhuki, ke kaumaha,
• nā wahi noho hoʻokolohua, ʻeha, hypotension,
• cardiovascular gagal ole, waha maloʻo, Stevens-Johnson syndrome,
• hoemi
• miki, wāaki, pale ʻeha, cholestasis,
• constipation, ʻeha o ka ʻili, ke kuʻuna, ʻeha i loko o ka ʻōpū.

Nā Hoʻohui Kūʻai

Me ka hoʻomohala piha ʻana o ka glycidone me Allopurinol, nā mea hoʻopaʻa aku nei i ka ACE, nā lāʻau antifungal, analgesics, derivatives Coumarin, NSAIDs a me nā mea ʻē aʻe, hiki ke hoʻonui ʻia ka hopena hypoglycemic o ka mea i hala.

Rifampicin, barbiturates, a me Phenytoin hoʻemi i ka hopena hypoglycemic o Glyurenorm.

Nā manaʻo loea

ʻAʻole pono nā loli no ka hypoglycemic no ka hoʻokūkū waha.

ʻO ka poʻe maʻi me ka maʻi maʻi e hāhai pono i nā ʻōlelo a pau a ke kauka.

Ke kū ʻia mai nā hōʻailona o ka hypoglycemia, pono koke ʻoe e ʻai i ka meaʻai i loaʻa ka kō.

Hiki i ke hoʻoikaika kino ke hoʻoikaika i ka hopena hypoglycemic o ka lāʻau.

Ma muli o ka hoʻopili ʻana o ka glycidone e nā kō, ua hōʻoluʻolu ʻia ka lāʻau lapaʻau i ka nīnau no ka maʻi maʻi, a me ka nephropathy maʻi maʻi.

I loko o nā haʻawina o ka lāʻau lapaʻau, ka mea i ʻike ai ka hoʻohana ʻia ʻana o ka lāʻau lapaʻau i ka nīnau no 30 mau mahina ʻaʻole i kōkua i ka hoʻonui ʻana i ka paona maʻi. Eia kekahi, loaʻa nō nā hihia o ka mālama kaumaha ma 1-2 kg.

Nā hōʻike a me nā loiloi

ʻO nā hua lāʻau i kapa ʻia i nā mea hoʻohālike o ka Glurenorm: Gliklada, Amiks, Glianov, Glayri, Glibetik.

Hiki i nā loiloi e pili ana i ka lāʻau lapaʻau i ka ʻokoʻa. Wahi a nā hōʻike pili huahana, ua maikaʻi loa kēia lāʻau a hiki i nā mea āpau. Eia nō naʻe, pono e hopohopo he nui nā maʻi e hopohopo nui e pili ana i ka papa inoa o nā hopena hōʻino o kēia hoʻoponopono. ʻOiai ke kau nei nā kauka he ʻeha loa loa ia a ma lalo o nā kūlana wale nō.