ʻO ka lāʻau Finlepsin: kuhikuhi i ka hoʻohana > He hoʻomaʻemaʻe a me ke pale aku

E like me nā kauoha i Finlepsin, ʻike nā hana no ka hoʻohana ʻana.

epilepsy (hui pū me nā luhina, lethargic, hopu kai myoclonic),
neuralgia idiopathic trigeminal,
neuralgia maʻamau a atypical trigeminal neuralgia i kumu o ka sclerosis,
idiopathic neuralgia o ke ake glossopharyngeal nerve,
kūlana hana manic kūloko (i ke ʻano o ka monotherapy a i ʻole hoʻoponopono hui like paha),
pili hanana-hopena hopena,
hue mele hōʻemi,
indipidus maʻi maʻi kumu waena,
polydipsia a me polyuria o ke kumu neurohormonal.

Nā ʻaihue Finlepsin

Ke kuhikuhi nei i nā ʻōlelo iā Finlepsin i kēlā mau contraindications no kona hoʻohana.

hypersensitivity ki carbamazepine,
ka hehi ʻana o ka iwi he kanopo hematopoiesis,
molphyria mololi
ka hoohana ʻana me MAO inhibitors,
Poloka AV.

Pono e hoʻohana ʻia ʻo Finlepsin me ka akahele i ka puʻuwai aloha decompensated, ADH hypersecretion syndrome, hypopituitarism, adrenal cortex insufficiency, hypothyroidism, hoʻonaninika kūlohelohe, wā kahiko, kūloko o ka puʻu, hoʻonui i ka paʻai intraocular.

Loaʻa ka hopena o ka finlepsin

Loaʻa ʻia nā hopena ʻokoʻa e pili ana i ka wā e hoʻohana ʻia ʻo Finlepsin:

ma ka ʻaoʻao o ka National Assembly: dizziness, headache, incaired thinking, ike, hallucinations, paresthesias, hyperkinesis, unmotivated agence,
mai ka ʻōpū o ka gastrointestinal: ka luaʻi, nausea, ka nui o nā transaminases hepatic,
mai CCC: hoʻonui a hoʻemi paha i ke kahe koko, hōʻemi i ka holo ʻana o ka puʻuwai, hōʻino i ka hoʻokele AV,
mai ka hematopoietic system: kahi emi o ka nui o neutrophils, nā keʻena koko keʻokeʻo, nā platelets,
mai nā huaʻala: oliguria, hematuria, nephritis, edema, renal failed,
mai ka papa hanu: pulmonitis,
mai ka pae endocrine: he hoʻonui i ka pae prolactin, i hele pū me ka galactorrhea, gynecomastia, kahi hoʻololi o ke pae o nā hormone thyroid,
nā mea ʻē aʻe: nā mea kūlohelohe, me nā maʻi Stevens-Johnson.

ʻO ka hapa nui o nā hopena hopena e kumu i nā loiloi maikaʻi ʻole o Finlepsin mai nā mea maʻi. No ka pale ʻana i ko lākou helehelena a hōʻemi paha i ka nui o ka nui, hiki iā ʻoe ke hoʻohana iā Finlepsin e like me ke kuhikuhi ʻana i nā nui kūpono a ma lalo o ka mākaʻi loea koʻikoʻi.

Ke ano o ke noi ana, dosage of finlepsin

ʻO ka Finlepsin no ka hoʻohana waha. ʻO ka hoʻomaka hoʻomaka ʻana no nā pākeke he 0.2-0.3 g i ka lā. Kūleʻa i luna ka dosage he 1,2 g.ʻO ka nui loa ka nui o kēlā me kēia lā he 1.6 g ʻO ke ʻano o ka laila i ʻōlelo ʻia i ʻekolu a ʻehā he mau dosis, lōʻihi i kahi ʻano - i hoʻokahi mau manaʻo.

ʻO ka pauku Finlepsin no nā keiki he 20 mg / kg. A hiki i ka makahiki 6, ʻaʻole hoʻohana ʻia nā papa Finlepsin.

Hoʻohui ʻia a Finlepsin me nā lāʻau lapaʻau ʻē aʻe

Loaʻa ka hoʻohana pinepine ʻana o Finlepsin me nā MAO inhibitors. Hiki i nā anticonvulsants hiki ke hōʻemi i ka hopena anticonvulsant o Finlepsin. Me ka mālama like pū ʻana o kēia lāʻau lapaʻau me ka waila valproic, hiki ke kūkulu ʻia nā pilikia o ka ʻike, coma. Hoʻonui ka Finlepsin i ka pauʻa o ka hoʻomākaukauʻana i ka lithium. Me ka hoʻohana like ʻana o nā macrolides, nā pākēneka saluran kalebona, isoniazid, cimetidine me Finlepsin, ke kaila plasma o ka piʻi o ka hope. Hoʻopau ka Finlepsin i ka hana o nā anticoagulants a me nā contraceptives.

Ke keu

Me ka overdose o Finlepsin, he hewaʻole i ka ʻike, kaumaha i ke kahe a me nā ʻōnaehana cardiovascular, paʻa i ke ʻano o ke koko, a me ka hōʻeha o ka ʻeha. ʻAʻole lāʻau kūikawā: gastage lavage, ka hoʻohanaʻana o laxatives a me nā enterosorbents. Ma muli o ka hiki nui o ka lāʻau lapaʻau e hoʻopili i ka protein plasma, ʻaʻole i maikaʻi nā maʻi pakanika peritoneal a me ka diuresis koi ʻia me kahi overdose o Finlepsin. Hoʻomaka ʻia ka hemosorption ma luna o nā ʻōpio. I nā keiki ʻōpiopio, hiki ke hoʻololi ʻia ke koko.

Ma muli o ka hana kūpono o kēia lāʻau lapaʻau, hiki i ka koho ʻana i nā ʻano lāʻau lapaʻau like ʻole, he kūpono nā loiloi o Finlepsin. Loaʻa ka lāʻau i ka hopena antiepileptic maikaʻi, kahi hopena analgesic no ka neuralgia.

Nā ʻōlelo kikoʻī

Ma mua o ka hoʻohana ʻana i kēia lāʻau lapaʻau, pono ia e noi i nā ʻōlelo aʻoaʻo no Finlepsin ma ka kikoʻī.

Ke koho ʻana i ka dosage kiʻekiʻe, pono e hoʻoholo i ka plasma kiʻekiʻe o ka carbamazepine. Hiki i ka hoʻoneʻe koke ʻana i ka lāʻau lapaʻau ke hoʻonāukiuki i kahi hopu epileptic. Pono ka nānā ʻana i nā tramsaminases hepatic i ka wā i kuhikuhi ai iā Finlepsin. Wahi a nā ʻōkuhi koʻikoʻi, hiki ke hoʻohana ʻia ʻo Finlepsin e nā mea maʻi me ka piʻi nui o ka intraocular, akā pono e nānā ʻia kēia mākaukau.

E hoʻokuʻu i ke ʻano a me ka ʻano

Loaʻa i ka Finlepsin ma ke ʻano o nā papa: ka pōʻai, me kahi bevel, keʻokeʻo, convex ma kekahi ʻaoʻao a me ke ʻano ʻōpiopio a me ka hopena o ka hōʻaiu - ma nā ʻaoʻao ʻē aʻe (10 pcs. In blisters, in cardboard packaging of 3, 4 or 5 blisters).

Kāleka i kēlā me kēia 1 papa:

mea waiwai: carbamazepine - 200 mg,
ʻO nā mea kōkua: gelatin, magnesium stearate, microcrystalline cellulose, sodium croscarmellose.

Lapaʻau lāʻau

ʻO Finlepsin ka lāʻau lapaʻau antiepileptic. Loaʻa iā ia nā hopena antipsychotic, antidiuretic a me antidepressant. I ka maʻi me ka neuralgia, hōʻike ia i kahi hopena analgesic.

ʻO ka hoʻokūkū o ka hana o ka carbamazepine ma muli o ka polaka o nā kahe sodium e hilinaʻi nei i ke kōkua, e kōkua ana i ka hoʻomau ʻana i nā membrane o nā neurons overexcited, e alakaʻi ana i ka pale ʻana o nā hoʻokuʻu o nā aʻa o nā nīne a me ka hōʻemi ʻana i ka hoʻokau ʻana i nā impulses i nā synapses. Hōʻalo ka hana o ka carbamazepine i ka hana hou ʻana o nā hana i hiki i nā cell neurololi depolarized, e hoʻoneʻe ana i ka hoʻokuʻu ʻana o ka glutamate (he ʻano hoʻōla ʻo neurotransmitter amino), e hoʻonui ana i ka paepae hopu o ka pūnao nīnū, a ma ka hopena, e hōʻemi i ka hōʻemi o ka hoʻokau epileptic. ʻO ka hopena anticonvulsant o Finlepsin ma muli hoʻi o ka loli o ke kahe e ʻike ʻia nei i nā kahe kaulike-gated Ca 2+ a me ka hoʻonui i ka K + conductivity.

ʻO Carbamazepine ka hana kūpono ma ka pīhoihoi epileptic ʻāpana a me ka ʻole o ka hoʻomohala ʻana i ka lua), me nā māka kaua a me nā maʻi o ka lawehala. ʻO ka lāʻau lapaʻau e hana pinepine ʻole a kūpono ʻole paha no nā mākiha liʻiliʻi (i hele aku, hopu i ka myoclonic, petit mal).

I nā mea maʻi me ka epilepsy (ʻoi aku i ka wā kamaliʻi a me ka wā ʻōpio), ʻo ka lāʻau lapaʻau e hoʻopilikia maikaʻi i nā hōʻailona o ke kaumaha a me ka hopohopo, a me ka hōʻemi hoʻi i ka huhū a me ka uluʻana.

ʻO ka hopena o Finlepsin ma ka hana psychomotor a me ka hana cognitive ka hilinaʻi ʻana i ka dosis.

Hoʻokomo ka hopena anticonvulsant o ka lāʻau mai nā hola he nui i kekahi mau lā, a i kekahi manawa a i hoʻokahi mahina.

I ka poʻe maʻi me ka neuralgia trigeminal, Finlepsin, ma ke ʻano ture, ka mea e pale ai i ka hōʻeha ʻana o nā ʻeha hōʻeha. ʻO ka nāwaliwali o ka maʻi ʻehaʻeha ua nānā ʻia i ka wā mai 8 a 72 mau hola ma hope o ka lawe ʻana i ka lāʻau.

Me ka hoʻoneʻe ʻana i ka waiʻona, hoʻonui ka carbamazepine i ka kaila o ka hoʻohaʻahaʻa no ka mākaukau paʻa ʻana, a me ka hōʻemi ʻana nō hoʻi i ka nui o nā hōʻailona lapaʻau e like me ka haʻalulu, hoʻonui ʻia irritability a me ka gait.

Hoʻopilikia ka hopena antipsychotic o ka lāʻau ma hope o nā lā 7-10, i pili i ka pale ʻana i ka metabolism o norepinephrine a me dopamine.

Lapaʻau lāʻau

Ke hele mālie nei ʻo Carbamazepine akā e nānā. ʻAʻohe kokoke i ka ʻai ʻana i ka pae a me ka wikiwiki o ka inu ʻana. Loaʻa ka wela plasma nui i nā hola 12 ma hope o ka lawe ʻana i hoʻokahi keneka. Loaʻa ka ʻike wai ʻana i ka Equilibrium plasma ma hope o 1-2 mau pule, e hilinaʻi ana i nā ʻano kumuhana o ka metabolism, me ka ʻano o ka lāʻau, ka kūlana o ka mea maʻi a me ka lōʻihi o ka lāʻau.

I nā keiki, ua hoʻopaʻa aku ka carbamazepine i nā protein plasma i ka 55-55%, i nā pākeke - e 70-80%. ʻO ka ʻike ʻike nui o ka hoʻoili ʻana i ka lāʻau he 0.8-1-1.9 l / kg. Kuʻi ʻo Carbamazepine i ka papale placental a hoʻopuka ʻia i ka umauma umauma (ʻo kona kaohi ʻia ʻana i ka waiū o kahi wahine hānai he 25-60% o ka paʻa ʻana o ka carbamazepine i ka plasma).

Hoʻomoe ka metabolism o ka lāʻau i ka puʻuwai, nui loa ma ke ala epoxy. I ka hopena, ua hoʻohālikelike ʻia nā metabolites koʻikoʻi: ka metabolite ikaika - carbamazepine-10,11-epoxide, ka metabolite hoʻi i ka hemahema - conjugate me ka waikiko glucuronic. Ma muli o nā hopena metabola, hiki i ka hoʻokumuʻana o ka metabolite kāohi ʻole, hiki i ka 9-hydroxymethyl-10-carbamoylacridane. ʻO ka paʻa ʻana o ka metabolite ikaika e 30% o ka ʻike ʻana o ka carbamazepine.

Ma hope o ka lawe ʻana i hoʻokahi pākahi o nā lāʻau, ʻo ka hapalua-ola he 25-65 hola, ma hope o ka hoʻohana hou ʻana i ka manawa - 12-24 mau hola (i ke ʻano o ka lōʻihi o ka mālama ʻana). I nā maʻi e loaʻa hou i nā anticonvulsants ʻē aʻe (no ka laʻana, ka phenobarbital a phenytoin) paha, ua hōʻemi ʻia ka hapalua-ola i 9-10 hola.

Ma hope o hoʻokahi pākahi o Finlepsin, ma kahi o 28% o ka nui i lawe ʻia ma ka ʻatikala a me 72% i loko o ka urine.

I nā keiki, ma muli o ka wikiwiki o ka hoʻopau ʻana i ka carbamazepine, pono e hoʻohana ʻia ka hoʻohana ʻana o nā kaha kiʻekiʻe o ka lāʻau pākahi i kg kilokino o ke kino.

ʻAʻole hāʻawi ʻia nā ʻikepili e pili ana i nā loli i ka pharmacokinetics o Finlepsin i nā poʻe maʻi maʻi.

ʻLoe a me ke kākele

Lawe ʻia ʻo Finlepsin me ka nui o ka wai a i ʻole nā ʻano wai ʻē aʻe. Pono e lawe ʻia nā papa me nā meaʻai a i ʻole ka ʻai ʻana.

Me ka epilepsy, ua hōʻike ʻo ia e kuhikuhi i ka lāʻau lapaʻau ma ke ʻano o ka monotherapy. Ke hui nei iā Finlepsin i ka hoʻomau antiepileptic lapaʻau, mālama pono a me ka lohi ʻana, inā pono, e hoʻoponopono ʻia i ka pau ʻana o nā lāʻau i hoʻohana ʻia.

Ke keʻe nei i ka pau aʻe, pono ʻoe e lawe i ka papa pākuhi i ka manawa e hoʻomanaʻo ana ka mea maʻi i kēia. ʻAʻole hiki iā ʻoe ke lawe i ka pālua ʻelua o ka lāʻauamaama.

No ka mālamaʻana i ka epilepsy, ʻo ka hoʻomaka mua ʻana o Finlepsin no nā pākeke a me nā wā'ōpiopio ma mua o 15 mau makahiki he 200-400 mg i kēlā me kēia lā. Ma hope iho, e hoʻonui pinepine ʻia ka nui a hiki i ka hoʻokō ʻia ʻana o ka hopena therapeutic. ʻO ka awelika mālama mālama maʻi o ka laikini mai 800 a 1200 mg i kēlā me kēia lā i ka 1-3 mau pōlika. ʻO ka palena kiʻekiʻe loa no nā pākeke he 1600-2000 mg i kēlā me kēia lā.

No nā keiki me ka epilepsy, ʻōlelo ʻia ka lāʻau lapaʻau i nā ʻano ʻehā.

kamaliʻi keiki 1,5 mau makahiki: 100-200 mau lā i ka lā i ka hoʻomaka ʻana o ka hoʻōla, ma hope iho, e hoʻonui pinepine ʻia ka ʻōpū ma 100 mg i kēlā me kēia lā a hiki i ka hopena hopena i makemake ʻia, ʻo 200 ka nui o ka mg o ka mālama ai i kēlā me kēia lā.
nā keiki i hala 6-10 mau makahiki: 200 mg i kēlā me kēia lā, i ka wā e hiki mai ana, e hoʻonui iki ʻia ka nui o 100 mg i ka lā a hiki i ka hopena hopena makemake ʻia, ʻo 400 ka nui o ka mālamaʻana i kēlā me kēia lā i nā 2-3.
nā keiki a me nā ʻōpio i kahi mau makahiki 11-15 makahiki: 100-300 mg i kēlā me kēia lā, ukali ʻia e ka piʻi wikiwiki ʻana ma ka 100 mg i kēlā me kēia lā a hiki i ka hopena i makemake ʻia, he 600-1000 mg ka nui o ka lā ma ka 2-3 mau lā.

Inā hiki ʻole i ke keiki ke ale i ka papa Finlepsin holoʻokoʻa, hiki ke ʻoki ʻia, ʻūlū ʻia a lūlū ʻia paha i ka wai a inu i ka hopena hopena.

ʻO ka lōʻihi o ka lāʻau no ka epilepsy i hilinaʻi i ka hōʻike a me ka pane o ka mea maʻi i ka maʻi. Hoʻoholo ke kauka i ka lōʻihi o ka lāʻau a i ʻole ka haʻalele ʻana iā Finlepsin pakahi no kēlā me kēia maʻi. ʻO ka nīnau no ka hoʻohaʻahaʻa ʻana i ka waʻa a i ʻole ke kau ʻana i ka lāʻau e noʻonoʻo ʻia ma hope o 2-3 mau makahiki o ka mālama ʻana, ma loko kahi o ka lawehala.

ʻO ka make o Finlepsin e hoʻemi iki ʻia ma luna o 1-2 mau makahiki, e kiaʻi mau ana i ka electroencephalogram. Me ka hoʻohaʻahaʻa ʻana i kēlā me kēia lā i nā keiki, pono ia e noʻonoʻo i ka hoʻonui ʻia o ka makahiki i ka nui o ke kino.

Me ka idiopathic glossopharyngeal neuralgia a me neuralgia trigeminal, kahi hoʻomaka mua o ka lāʻau lapaʻau he 200-400 mg i kēlā me kēia lā. I ka wā e hiki mai ana, ua hoʻonui ʻia ʻo 400-800 mg ma 1-2 mau ʻāpana. Hoʻomau ka hoʻomaʻamaʻa ʻana a hiki wale aku i ka ʻehaʻeha. I kekahi mau mea maʻi, hiki i ka hoʻohana 'ana i ka carbamazepine ma kahi mālama mālama haʻahaʻa - 200 mg palua i kēlā me kēia lā.

I ka poʻe maʻi maʻi a me ka poʻe me ka hypersensitivity iā Finlepsin, ua kauoha ʻia ka lāʻau lapaʻau i loko o kahi hopena mua loa, ʻo ia ka 200 mg i kēlā me kēia lā i ʻelua mau puʻu.

Hoʻomaka ʻia ka lāʻau lapaʻau hoʻohemo maʻi i loko o ka haukapila. Hāʻawi ʻia ka lāʻau lapaʻau i loko o kahi awelika o kēlā me kēia lā o 600 mg i 3 mau puʻupuʻu māhele. I nā hihia koʻikoʻi koʻikoʻi, hoʻonui ka nui o ka carbamazepine i 1200 mg i kēlā me kēia lā i 3 mau puʻupuʻu māhele. Inā kūpono, hiki ke hoʻohana ʻia ka lāʻau lapaʻau i ka manawa like me nā lāʻau ʻē aʻe no ka mālama ʻana i ka maʻi hōʻemi o ka ʻona. Hoʻomaʻamaʻa iki ka mālama ʻana ma luna o nā manawa 7-10 lā. I ka holo ʻana o ka manawa holoʻokoʻa, pono e nānā pono ka mea maʻi ma muli o ka hiki ke hoʻomohala ʻia o nā hopena ʻaoʻao mai ka hoʻopili.

No nā maʻi e kū ana mai ka neuropathy maʻi maʻi, ua kauoha ʻia ʻo Finlepsin i ka awelika o kēlā me kēia lā he nui o 600 mg ma 3 mau puʻupuʻu māhele. I nā hihia kūikawā, hoʻonui ka nui i ka 1200 mg i kēlā me kēia lā i 3 mau puʻupuʻu māhele.

No ka mālamaʻana a me ka pale ʻana i ka maʻi psychosis, ua hoʻomaopopo ʻia ka carbamazepine i loko o kēlā me kēia lā o 200-400 mg me ka hoʻonui ʻana o ka wai, inā pono, i 800 mg i kēlā me kēia lā i nā 2 mau kuleana.

Me nā mea hoʻokūkū epileptiform e pili ana i ka sclerosis lehulehu, ua kauoha ʻia ʻo Finlepsin i kahi maʻa o 400-800 mg ma nā papa ʻelua.

Nā hopena hopena

ʻO nā hopena ʻaoʻao o ka lāʻau mai ka kikowaena kūloko o ka hopena he hopena paha i kahi kau palena nui o ka carbamazepine a i ʻole ka nui o ka loli ʻana i ka ʻike o ka lāʻau i ka koko.

I ka wā o ka mālama ʻana me Finlepsin, hiki mai paha nā hopena hopena mai kēia ʻaoʻao a me nā hanana hope:

ʻōnaehana o ka hana: pinepine ka waha, ka luaʻi, ke kuʻina, ka nui o ka hana o ka phosphatase alkaline a me ka gamma glutamyl transferase, i kekahi manawa constipation a ʻeha paha, ʻeha i loko o ka ʻōpū, hoʻonui i nā hana o nā huina o nā huina, a ʻoiau o stomatitis, gingivitis, glossitis, parenchymal a cholestatic hepatitis, hepatitis granulomatous, jaundice, pancreatitis, hōʻeha ate,
pūnao cardiovascular: paʻakikī - hoʻonui a emi paha i ke kahe o ke koko, hoʻomohala a i ʻole ka ulu ʻana o ka puʻuwai kani ʻole, bradycardia, exacerbation o ka maʻi naʻau coronary, thromboembolic syndrome, hoʻokōkuhi intracardiac, hōʻemi o ka atrioventricular, i hui pū ʻia e nāwaliwali, thrombophlebitis, ka hemo.
kaila o ka lae kikowaena: pinepine ka ʻeha, ka ʻeha, ka dizz, paresis o ka noho ʻana, ataxia, ka nāwaliwali holoʻokoʻa, i kekahi manawa heststm, nā lōkuhi ʻano maʻamau, loaʻa ʻole ka nalo ʻana, ka hopohopo, haʻi i ka hopohopo, nāwaliwali o ka naʻau, ka hoʻopuka ʻana o ka psychomotor, nā kaumaha, ka paresthesia, nā hōʻailona paresis, auditory a ʻike hoʻokele paha, nā kuhi oculomotor, disorientation, peripheral neuritis, ʻano ikaika, hoʻonaninau ʻana i ka psychosis, pilikia choreoathetoid,
nā hui kuʻuna: paʻakikī - conjunctivitis, uhi ʻana o ka lens, nā haunaele i ka ʻono, hoʻomaʻamaʻa ʻana ka lohe, hoʻonui i ka naʻau intraocular,
Pūnaehana genitourinary: luhi - mālama i ka urinary, pinepine o ka urination, hana hoʻopōlohelohe hana, interstitial nephritis, hoʻemi ka potency, hōʻemi renal,
musculoskeletal system: loaʻa ʻole - nā palaka, ka ʻeha ma nā ʻōpū a me nā ʻāpana,
ka hoʻōla a me ka hoʻokaʻawale endocrine: pinepine - hoʻonui i ke kaumaha o ke kino, edema, hyponatremia, mālama mālama i ka wai, iki ʻole - hoʻonui i ke keokeo o ka hormone hoʻouluulu a me ka prolactin, hoʻemi i ka hoʻoliʻi o ka L-thyroxine, calcium impaired a me ka hoʻoliʻiʻana o ka phosphorus i loko o ka iwi iwi, hypertriglyceridemia, hypercholesterolemia, osteomalacia, hirsutism hoʻonui ʻia nā lymph nodes
hematopoietic system: pinepine - eosinophilia, thrombocytopenia, leukopenia, jarang - agranulocytosis, leukocytosis, reticulocytosis, hemolytic, megaloblastic a me aplastic anemia, lymphadenopathy, splenomegaly, defic acid acid, true erythrocyte aramid,
ke ʻano o ka maʻi pā: pinepine - palupalu nettle, i kekahi manawa - ke kauā ʻana o ka ʻōpū i nā ʻano hypersensitivity type-organ, kūlia anaphylactoid, pneumonitis alerine, edema Quincke, aseptic meningitis, eosinophilic pneumonia, ʻokoʻa - ʻeha ka ʻili o ka ʻōpū, ʻehaʻawa ʻo ka ʻālopoly epidermality, ʻōpala o ka lupus, photosensitivity, multiformitivity, multiformitivity, multiformit
nā kumuhana ʻē aʻe: huehue, palu lauoho laupala, purpura, kahe nui, ke kālaʻa kino.

ʻŌpū a me ka lactation

ʻOi aku ka maikaʻi o nā wahine o ka wā hānau keiki e kuhikuhi iā Finlepsin ma ke ʻano o ka monotherapy a ma ka hopena haʻahaʻa haʻahaʻa loa, ʻo ka nui o nā maʻi congenital i loko o nā pēpē i loaʻa i ko lākou mau māmā a me ka therapy antiepileptic kiʻekiʻe ma mua o nā pēpē i loaʻa nā makuahine i ka carbamazepine wale nō.

ʻO nā wahine hāpai wahine, ʻo ia hoʻi i loko o ka trimester mua, ua kuhikuhi ʻia ka lāʻau lapaʻau me ka mālama ʻana, me ka mālama ʻana i nā mea i manaʻo ʻia a i nā hopena hoʻopiʻi paha. Hiki i ka Finlepsin ke hoʻonui i ka pilikia o ka ulu o ka ulu o ka intrauterine i nā pēpē hou i loaʻa ai ka mau makuahine i ka epilepsy.

ʻO ka lāʻau antiepileptic e hoʻonui i ka nele o ka wai folic, i ʻike pinepine ʻia i nā wahine hāpai, no laila e hoʻolālā ana i ka wā e hāpai ana i ka wā e hānau ai, ua ʻōlelo ʻia ka hoʻokele prophylactic o ka folic acid. I mea e pale ai i nā maʻi hemorrhagic i loko o nā pēpē, makemake ʻia nā wahine ma ka hopena o ka wā e hāpai a i nā pēpē hou₁.

Lā ʻo Finlepsin i ka waiū umauma, no laila me ka hoʻomau mau ʻana i ka wā o ka wā e hāpai ai i ka ʻōpū o ka maʻi, hiki ke loiloi ʻia nā pono no ka makuahine a me ka hiki paha i ka pēpē.

Hoʻohui nūhou

Ke piʻi nei ke kukuna o ka carbamazepine i loko o ke koko me ka hoʻohana pinepine ʻana iā Finlepsin me nā mea pili aʻe a me ka hoʻomākaukau ʻana (hoʻoponopono ʻia o ka hoʻoponopono ʻia ʻana o ka carbamazepine a i ʻole ka ʻike ʻana i kona ʻano ma ka plasma e pono ai:: felodipine, viloxazine, fluvoxamine, acetazolamide, desipramine, verapamil, dextropropoxyphene, wale nō i nā pākeke a i nā helu kiʻekiʻe), diltiazem, azoles, macrolides, loratadine, isoniazid, HIV protease inhibitors, terfenadine, propoxyphene, hua kanu huaʻai.

Ka hoʻoneʻe ʻana o ka ʻai o ka carbamazepine i loko o ke koko me ka hoʻohana pū ʻana aku iā Finlepsin me nā mea waiwai aʻe a me ka hoʻomākaukau ʻana: phenytoin, metsuximide, theophylline, cisplatin, fenobarbital, primidone, rifampicin, doxorubicin, fensuximide, ʻona pūhōneʻōneke, oxonima, kahima, ʻona.

Carbamazepine e emi wai koko nā hoʻohui like o na kēia mau ai ': clonazepam, ethosuximide, valproicʻakika, dexamethasone, prednisolone, tetracycline, methadone, theophylline, lamotrigine, tricyclic antidepressants, clobazam, digoxin, primidone, alprazolam, cyclosporine, haloperidol, ku una ha anticoagulants, topiramate, felbamate, clozapine , Ka inhibitors o ka protease HIV, ka hoʻomākaukau ʻana i ka waha me ka progesterone a me / a me ka estrogens, nā mea hōʻiliʻili o ka calcium, tiagabine, levothyroxine, olazapine, risperidone, ciprasidone, oxcarbazepi n, praziquantel, tramadol, itraconazole, midazolam.

Me ka hoʻohana pū ʻana o Finlepsin a me ka hoʻomākaukau lithium, hiki ke hoʻonui ʻia i ka hopena neurotoxic o nā lāʻau ʻelua, me ka tetracyclines - hiki iā ia ke hoʻonāwaliwali i ka hopena therapeutic o carbamazepine, me ka paracetamol - hiki i ka hopena o nā hopena ʻaloi o ka paracetamol ma ka nui o ka ʻōpū a hoʻemi ʻia kona hopena, me ka hoʻōho ʻana o ka mana, a me ka hoʻohaʻahaʻa. e pā ana ka hoʻohanihua, me ka isoniazid - ua hoʻonui ʻia ka hopena hepatotoxic o isoniazid, me nā koikoi non-depolarizing - ua palupalu ka hopena. Muscle relaxants, me ka myelotoxic ai '- carbamazepine hoʻokāʻoi haematotoxicity.

ʻO ka hopena anticonvulsant o Finlepsin e hoʻoneʻe me ka hoʻohana pinepine ʻana me ka pimozide, haloperidol, clozapine, phenothiazine, molindone, maprotiline, thioxanthenes a me nā antidepresi tricyclic.

Hoʻonui ka Carbamazepine i ka metabolism o nā mea hoʻohālikelike hormonal, kūlohelohe anticoagulants, anesthetics, praziquantel a me ka waikawa folic, a hiki ke hoʻonui pū i ka huna ʻana o nā hormone thyroid.

ʻO nā hui o Finlepsin: Zeptol, Carbamazepine, Carbamazepine-Akrikhin, Carbamazepin-Ferein, Carbamazepine retard-Akrikhin, Tegretol TsR, Tegretol, Finlepsin retard.

ʻO nā loiloi no Finlepsin

ʻO nā mea maʻi i lawe i ka lāʻau lapaʻau no kekahi mau makahiki, a me ko lākou mau ʻohana, waiho i nā loiloi loiloi maikaʻi no Finlepsin, ʻoiai ua pau ka mālama ʻana i ka epilepsy ma muli o ka mālama ʻana. I ka manawa like, ʻike kekahi mau maʻi i ka hopena maikaʻi o ka lāʻau ma ka hana naʻauao. Ma keʻano pilikino, ua ʻike lākou i ka mau hōʻino o ke kamaʻilio a me ke ʻano o nā apathy.

Ua ʻike ʻia ʻo Finlepsin ma ke ʻano maikaʻi no ka hōʻeha ʻana i nā panic, akā ua hoʻomau ʻia ka hana o ka gait i kekahi mau maʻi.

Ka hana lāʻau lapaʻau

Kekahi antiepileptic lāʻau (dibenzazepine derivative), kahi ona antidepressant, antipsychotic a me antidiuretic hopena, he hopena analgesic i nā mea maʻi me neuralgia.

Hoʻopili nā ka hana o ka hana me ka blockade o nā kahe sodium-gated volt, kahi e hiki ai i ka hoʻokūkū o ka membrane o nā neurons overexcited, kaohi ʻana i ke ʻano o nā kahe mai o nā neurons a me ka hoʻohaʻahaʻa i ka conduction synaptic impulse. Māhele i ka hana hou ʻana o nā pahuhopu hana holoʻokoʻa o Na + -d hilinaʻi i nā neurons depolarized. Hoʻēmi i ka hoʻokuʻu ana i ka neʻe neurotransmitter amino acid - glutamate, hoʻonui i ka paepae hoʻohemo haʻahaʻa o ke kikowaena kūloko o ke kikowaena, a no laila, e hōʻemi ana i ka hopena o ka hoʻomohala ʻana i kahi lawe epileptic. Hoʻonui ʻo ia i ka K + conductivity, hoʻololi i nā kaheea-gated Ca 2+ channel, hiki iā ia ke hāʻawi pū i ka hopena anticonvulsant o ka lāʻau.

ʻO ka hana kūpono no ka hilo (ʻāpana) paʻakikī (maʻalahi a paʻakikī), i ʻole a i ʻole hele pū ʻia me ka ʻōhulu kuʻuna, no ka hoʻokūkū epileptic epiceptic e pili ana i ka maʻi, a me ka hoʻohui pū ʻana o kēia mau ʻano kaulima. petit mal, nā hōʻeha a me nā hopu Myoclonic). ʻO ka maʻi me ka epilepsy (ʻoi aku ka nui o nā keiki a me nā ʻōpio) he hopena kūpono i nā hōʻailona o ka hopohopo a me ke kaumaha, a me ka kaohiʻana o ka huhū a me ka uluʻana. Hoʻomaopopo ka hopena i ka hana cognitive a me ka hana psychomotor. ʻO ka hoʻomaka ʻana o ka hopena anticonvulsant mai nā hola he nui i kekahi mau lā (i kekahi manawa a hiki i ka 1 mahina ma muli o ka auto-induction o ka metabolism).

Me ka neuralgia kūloko koʻikoʻi a me ke kākau ʻana, ʻo ka carbamazepine i ka nui o nā hihia e pale ai i ka hoʻomaka ʻana o nā hōʻeha hōʻeha ʻana. Hoʻomaopopo ka hōʻeha ʻana i ka ʻeha ma neuralgia trigeminal ma hope o 8-75 hola.

I ka hihia o ka hoʻoneʻeʻana i ka waiʻona, hoʻonui i ka paepae o ka mākaukau paʻa, me ka hoʻohaʻahaʻa ʻia ma kēia ʻano, a me ka hōʻemi ʻana i nā mea i ʻike ʻia i ka maʻi lapaʻau o ka maʻi (hoʻonui i ka excitability, nā hiʻi, hana a nā hana hanit).

Hoʻopilikia ka hana Antipsychotic (antimaniacal) ma hope o 7-10 lā, hiki ma muli o ke kaohi ʻana o ka metabolism o ka dopamine a me norepinephrine.

Hoʻomoe ka lōʻihi e hana i ka mea e mālama ai i ka paʻa mau o ka lāʻauamaama i loko o ke koko ke lawe ʻia ʻo 1-2 mau manawa i kēlā lā.

ʻŌpū a me ka lactation

I ka manawa hiki, ʻōmole Finlepsin ® i ʻōlelo ʻia i nā wāhine o ka hānau ʻana me ke ʻano monotherapy, ma kahi pāʻina liʻiliʻi pālua, e like me ʻoi aku ka nui o ka malenations ʻana o nā pēpē hou mai nā makuahine i lawe i ka ʻano antiepileptic hui ʻia ʻoi aku ka ʻoi me ka monotherapy.

I ka wā e loaʻa ai ka hapai, pono e hoʻohālikelike i ka pono o ka lapaʻau ʻia a me nā hoʻopiʻi hiki paha, ʻoi aku hoʻi i ka trimester mua o ka hāpai ʻana. Ua ʻike ʻia na keiki o nā makuahine e loaʻa ana i ka epilepsy i predisposed i ka ulu ulu ʻana o ka hana hōʻeuʻeu a me ke kino, me ka malformations. Hiki i ka retard Finlepsin ® ke hoʻonui i ka hopena o kēia mau pilikia. Aia kekahi hōʻike kūʻokoʻa i nā hihia o nā maʻi a me nā hanaʻino, me ka hoʻopiʻi ʻole ʻana i nā pā o ka vertebral (spina bifida).

Hoʻonui ka lāʻau antiepileptic i ka nele o ka folic acid, i ʻike pinepine ʻia i ka wā hāpai, hiki iā ia ke hoʻonui i ka nui o ka hānau ʻana o ka hānau ʻana i nā keiki, no laila, ʻo ka lawe ʻana i ka waikawa folic e ʻōlelo ʻia ma mua o ka wahine i hoʻolālā ʻia a i ka wā hāpai. I mea e pale ai i nā hoʻopiʻi hemorrhagic i nā mea hou, ua ʻōlelo ʻia i nā wahine i nā mau pule hope o ka wā o ka hapai, me nā pēpē hou, e hāʻawi ʻia i ka vitamina K.

Hōʻalo ka Carbamazepine i ka waiū umauma, no laila ʻo nā pōmaikaʻi a me nā hopena i makemake ʻole ʻia e like me nā hopena o ka umauma pono e hoʻohālikelike me ka hoʻomau ʻana i ka maʻi maʻamau. Me ka umauma hoʻomau i ka wā e lawe nei i ka lāʻau lapaʻau, pono ʻoe e hoʻokumu i ka nānā ʻana no ke keiki e pili ana i ka hiki ke hoʻomohala ʻana i nā hopena ʻino (ʻoi aku ka hoʻohālikelike, ke kaumaha ikaika, ʻomaʻomaʻi a me nā maʻi ʻokoʻa)

ʻLoe a me ke kākele

I lokoi ka manawa a ma hope o ka ʻai ʻana me ka nui o nā ʻano wai. No ka hōʻoluʻolu o ka hoʻohana ʻana, hiki i ka papaʻaina (me kona hapalua a i ʻole hapa paha) ke hoʻohena mua i ka wai a wai wai wai, no ka mea hoʻomau ʻia ka waiwai o ka hoʻokuʻu ʻana o ka mea hana ma hope o ka pau ʻana o ka papa papa i loko o kahi wai. ʻO ka pae o nā pona i hoʻohana ʻia he 400-100 mg / lā, kahi i hoʻokaʻawale ʻia i 1-2 mau lā i kēlā me kēia lā.

Pono e hoʻonui ka nui o ka lā ma mua o 1600 mg.

I nā hihia kahi e hiki ai, pono ʻo Finlepsin ® retard e kuhikuhi i ka monotherapy. Hoʻomaka ka hoʻolālā ma ka hoʻohana ʻana i kahi liʻiliʻi o kēlā me kēia lā, kahi e hoʻonui mālie a hiki i ka hopena maikaʻi loa. ʻO ka hoʻohui ʻana o ka loina o Finlepsin ® i kahi hoʻomau antiepileptic e hana pono ʻia, e neʻeneʻe pono ʻia, ʻoiai nā ʻano o nā lāʻau i hoʻohana ʻia, ʻaʻole i loli a i ʻole, inā pono, pololei. Inā poina ka mea maʻi e lawe i kahi ma hope o ke ʻano o ka lāʻau lapaʻau i ka manawa kūpono, pono koke e lawe ʻia ka nui hala i ka manawa ua ʻike ʻia kēia hala ʻole, a pono ʻoe e lawe i ka pālua ʻelua o ka lāʻau.

Nā pākeke ʻO 200 ka hopena mua loa he 200-400 mg / lā, a laila piʻi mālie ka hopena a hiki i ka hopena kūpono loa. ʻO ka lā mālama mālama ʻia 800-1200 mg / lā, kahi i hoʻokaʻawale ʻia i loko o 1-2 mau lā i kēia lā.

E na keiki. ʻO ka dosis mua no nā keiki mai 6 a 15 mau makahiki he 200 mg / lā, ma laila e hoʻonui iki ʻia ka nui o 100 mg / lā a hiki i ka hopena kūpono loa. ʻO ke kākoʻo ʻana i nā kaila no nā keiki he 6-10 mau makahiki he 400-600 mg / lā (i 2 iniha), no nā keiki he 11-15 mau makahiki - 600-1000 mg / lā (ma 2 mau doses).

Kālai ka lōʻihi o ka hoʻohana ʻana i nā hōʻike a me ke pane kūʻokoʻa o ka mea maʻi i ka mālama ʻana. ʻO ka hoʻoholo e hoʻoneʻe i ka mea maʻi i ka retard Finlepsin ®, ʻo ka lōʻihi o kona hoʻohana a me ka hoʻopau ʻia ʻana o ka mālama ʻana ke lawe kūʻokoʻa ʻia e ke kauka. ʻO ka hopena o ka hōʻemi ʻana i ka nui o ka lāʻau a i ʻole ke kāpae nei i ka mālamaʻana e manaʻo ʻia ma hope o kahi makahiki o 2-3 mau makahiki o ka waiho ʻole ʻana o ka hopu.

Hoʻomaʻamaʻa ka hoʻomaʻamaʻa, hoʻoemi kaulike i ka make o ka lāʻau no 1-2 mau makahiki, ma lalo o ka mana o ka EEG. I nā keiki, me ka hoʻohaʻahaʻa ʻana i kēlā me kēia lā o ka lāʻau, pono ke hoʻonui i ka paona i ke kino me ka makahiki.

Neuralgia Trigeminal, idiopathic glossopharyngeal neuralgia

ʻO ka dosis mua he 200-400 mg / lā, i hoʻokaʻawale ʻia i 2 mau pona. Hoʻonui ʻia ka ʻōmua mua a hiki i ka ʻeha ʻana o ke kaumaha, ma ka awelika a hiki i ka 400-800 mg / lā. Ma hope o kēlā, i kekahi mahele o nā mea maʻi, hiki ke hoʻomau ʻia ka mālama ʻana me kahi hoʻohaʻahaʻa haʻahaʻa o 400 mg.

Ua kuhikuhi ʻia ka retlepsin ® retard i nā mea maʻi a me nā mea maʻi e pili ana iā Karabamazepine ma kahi ma mua o ka 200 mg hoʻokahi i ka lā.

ʻEha i ka maʻi neuropathy maʻi

ʻO ka awelika o kēlā me kēia lā he 200 mg kakahiaka a me 400 mg i ke ahiahi. I nā hihia kūʻokoʻa loa, hiki ke kuhikuhi ʻia ke kaila Finlepsin ® i loko o ka hopena o 600 mg 2 mau manawa i ka lā.

Ka hopena o ka hoʻoneʻe ʻana i ka ʻeha i kahi haukapila

ʻO ka awelika o kēlā me kēia lā he 600 mg (200 mg i ke kakahiaka a me 400 mg i ke ahiahi). I nā pilikia koʻikoʻi, ma nā lā mua, hiki ke hoʻonui ʻia i ka nui i 1200 mg / lā, i hoʻokaʻawale ʻia i 2 mau pūmole.

Inā pono, hiki ke hui pū me ka retard Finlepsin ® me nā mea ʻē aʻe i hoʻohana ʻia e mālama ai i ka hoʻoneʻe ʻana i ka waiʻona, i mea hoʻohui aku i ka sedative-hypnotics.

I ka wā o ka mālamaʻana, pono ia e kiaʻi pinepine i nā kiko o ka carbamazepine i loko o ke koko koko.

I ka pilina me ka hiki ke hoʻomohala ʻia o nā hopena ʻaoʻao mai ka kikowaena waena a me ka pūnaha hoʻonaʻauao autonomic, e nānā pono ʻia nā mea maʻi i kahi ʻōlapa.

ʻO ka hoʻopaʻapaʻa Epileptiform i nā sclerosis lehulehu

ʻO ka awelika o kēlā me kēia lā he 200-400 mg 2 mau manawa i ka lā.

Hoʻomaʻamaʻa a me ke pale aku i ka maʻi maʻi

Lā ka wā mua a me ka mālama mālama ʻana like - 200-400 mg / lā. Inā makemake, hiki ke hoʻonui ʻia i ka make ma 400 mg 2 mau manawa i ka lā.

Hoʻopili pū me nā lāʻau ʻē aʻe

ʻO ka hoʻokolohua hoʻokahi o ka carbamazepine me nā CYP3A4 inhibitors hiki ke alakaʻi i kahi hoʻonui i kona kaohi ʻana i ke koko koko a me ka hopena i ka hopena maikaʻiʻole. ʻO ka hoʻohana pū ʻana o CucP3A4 inducers hiki ke alakaʻi i ka wikiwiki o ka metabolism o ka carbamazepine, kahi e hoʻoneʻe nei i ka ʻai o ka carbamazepine i loko o ke koko koko a me ka hoʻokaʻawale ʻana i ka hopena therapeutic, ma kahi ʻē aʻe, hiki i kā lākou hiki ke hōʻemi i ka piʻi ʻana o ka biotransformation o carbamazepine a e alakaʻi i ka hoʻonui ʻana i ka ʻike.

Ka ke ʻano o ka ʻailaama i loko o ka plasma e hoʻonui ʻia e ka verapamil, diltiazem, felodipine, dextropropoxyphene, viloxazine, fluoxetine, fluvoxamine, cimetidine, acetazolamide, danazole, desipramine, nicotinamide (ma na dewasa, e wale nō i nā dosis) (itraconazole, ketoconazole, fluconazole), terfenadine, loratadine, isoniazid, propoxyphene, hua ʻōpala, nā mea hoʻohui o ka protease hoʻohana ʻia i ka hoʻohana ʻana i ka maʻi o ka maʻi HIV (no ka laʻana ka ritonavir) - koi ʻia ka hoʻoponopono hoʻoponopono ʻia. a me ka nānā 'ana i nā kukuna plasma o ka carbamazepine.

Hoʻopili ʻo Felbamate i ka hoʻoneʻeʻana o ka carbamazepine i ka plasma a hoʻonui i ke kao o ka carbamazepine-10,11-epoxide, aʻo kahi hoʻokaʻawale manawa o ka neʻe i ka serum o ka felbamate hiki.

Hoʻemi ʻia ka ʻike o ka carbamazepine e ka phenobarbital, phenytoin, primidone, metsuximide, fensuximide, theophylline, rifampicin, cisplatin, doxorubicin, hiki ke clonazepam, valpromide, valproic acid, oxcarbazepine a me nā mea kanu nā hua wili ʻo John John. (Hypericum perforatum). ^ E Ha yM. Aia ka hiki o ka haʻalele o ka carbamazepine e ka waima valproic a me ka primidone mai ka pilina me nā protein plasma a me ka hoʻonui ʻana o ka ʻike i ka metabolite hoʻāla a ka pharmacologically active (carbamazepine-10,11-epoxide). Me ka hoʻohana pū ʻana o ka finlepsin me ka acid valproic, i nā mea kūʻokoʻa, hiki i ka coma a me ka hilahila. Hoʻololi ʻo Isotretinoin i ka bioavailability a me / a i ʻole ke kala ʻana o ka carbamazepine a me ka carbamazepine-10,11-epoxide (ka nānā ʻana i ke kukuna o ka carbamazepine i ka plasma mea pono).

Hiki i ka Carbamazepine ke hōʻemi i ka kukuna plasma (hōʻemi a hōʻemi ʻole paha i nā hopena) a koi i ka hoʻoponopono ʻana o nā lāʻau lapaʻau i kēia lā: clobazam, clonazepam, digoxin, ethosuximide, primidone, valproic acid, alprazolam, corticosteroids (prednisolone, dexamethasone), cyclosporin, docyclic haloperidol, methadone, hana hoʻomākaukau waha no ka estrogens a me / a progesterone (ke koho ʻana i nā ʻano hana ʻē aʻe o ka contraception he pono), theophylline, oral anticoagulants (warfarin, fenprocoumone, dicumar la), lamotrigine, topiramate, antidepresan tricyclic (imipramine, amitriptyline, nortriptyline, clomipramine), clozapine, felbamate, tiagabine, oxcarbazepine, inhibitor protease e hoʻohana ana i ka mālama ʻana i ka maʻi HIV (indinavir, ritonavir, saquidine, felodipine), itraconazole, levothyroxine, midazolam, olanzapine, praziquantel, risperidone, tramadol, ziprasidone.

Aia nā hopena o ka hoʻonui ʻana a i ka hoʻohaʻahaʻa paha i ka phenytoin i loko o ke kaila koko me ka hope o ka carbamazepine a me ka hoʻonui i ka pae o mefenytoin. Me ka hoʻohana like ʻana o ka mahama carbamazepine a me ka hoʻomākaukau lithium, hiki ke hoʻonui ʻia nā hopena neurotoxic o nā mea ikaika ʻelua.

Hiki ke komo ka Tetracyclines i ka hopena therapeutic o ka carbamazepine. Ke hui pū me ka paracetamol, i ka nui o ka hopena o ke aʻalopiko i ka puhaka e hoʻonui ai i ka pehu a me ka hoʻohaʻahaʻa i ke ʻano therapeutic (e hoʻoluhi ana i ka metabolism o paracetamol).

ʻO ka hui like ʻana o ka carbamazepine me ka phenothiazine, pimozide, thioxanthenes, mindindone, haloperidol, maprotiline, clozapine a me nā tricyclic antidepressants e alakaʻi i ka hoʻonui i ka hopena o ka inhibitory ma ka pūnaehana ʻōiwi a me ka nāwaliwali i ka hopena anticonvulsant o ka carbamazepine.

Hoʻopau ka pale ʻana MAO i ka hiki o ka hoʻomohala ʻana i ka ulu ʻana o ka hyperpyrethmic, ke piʻi ʻana o ka hypertensive, ka hoʻokolohua, a me ka hopena o ka make (ʻo MAO inhibitors e hoʻihoʻi i ka liʻiliʻi ma 2 mau pule ma mua a i ʻole i kuhikuhi ʻia ai ka carbamazepine, a i ʻole inā ʻae ʻia ke kūlana haumania, ʻoi aku no kahi manawa lōʻihi).

ʻO ka lawelawe manuahi me ka diuretics (hydrochlorothiazide, furosemide) hiki ke alakaʻi i ka hyponatremia, i hoʻopili ʻia e nā hōʻike maʻi.

Ua komo i ka hopena o ka hoʻomaha a i ʻole depolarizing kalamale (pancuronium). I ka hoʻohana ʻana i kēlā hui like ʻole, pono paha e hoʻonui i ka ʻai ʻana o nā hoʻomaha hoʻomaha mus, ʻoiai ka mākaʻikaʻi ʻana i ke ʻano o ka mea maʻi e pono ai ma muli o ka hikiwawe o ka wikiwiki o ka hoʻomaha ʻana o nā hoʻomaha hoʻomaha o nā ʻōpū.

Hōʻemi ka Carbamazepine i ka hoʻomanawanui etanol.

Hoʻonui i nā lāʻau Myelotoxic i ka hematotoxicity o ka lāʻau.

Hoʻonui ia i ka metabolism o nā anticoagulants kūlike, hormonal contraceptives, folic acid, praziquantel, a hiki ke hoʻonui i ka hoʻopau ʻana o nā hormone thyroid.

Hoʻonui ia i ka metabolism o nā lāʻau no ka anesthesia (enflurane, halotane, fluorotan) a hoʻonui i ka hopena o nā hopena hepatotoxic, hoʻonui i ka hoʻokumu ʻana o nā metabolites nephrotoxic o methoxyflurane. Hoʻonui i ka hopena hepatotoxic o isoniazid.

Nā hiʻohiʻona noi

Hoʻomaka ka Monotherapy o ka maʻi epilepsy me ke koho ʻana i kahi hopena haʻahaʻa haʻahaʻa haʻahaʻa, e hoʻonui i ka hoʻonui a hiki i ka loaʻa ʻana o ka hopena therapeutic makemake.

Ke koho nei i ka momona kūpono, pono e hoʻoholo i ka ʻike ʻana o ka carbamazepine i loko o ke koko koko, ʻoi aku hoʻi me ka hui pū ʻana. I kekahi mau manawa, hiki ke hoʻoweliweli ka nui o ka maʻi kūpono mai nā ʻōlelo aʻoaʻo mua a mālama mālama ʻia, no ka laʻana, no ka pili me ka hoʻonuhulu ʻana o nā hāmeʻa o ka mikrosomal a i ʻole no ka hoʻopili ʻana me ka therapy hoʻohui.

ʻAʻole pono e hui pū ʻia nā Carbamazepine me nā lāʻau lapaʻau sedative-hypnotic. Inā pono, hiki ke hoʻohui ʻia ʻo ka retard Finlepsin ® me nā mea ʻē aʻe i hoʻohana ʻia e mālama ai i ka hoʻokuʻu ʻana i ka wai. I ka wā o ka mālamaʻana, pono ia e kiaʻi pinepine i nā kiko o ka carbamazepine i loko o ke koko koko. I ka pilina me ka hoʻomohala ʻana i nā hopena ʻaoʻao mai ka Central and autonomic nervous system, nānā pono nā mea maʻi i kahi ʻōna o ke haukapila. Ke hoʻihoʻi nei i ka mea maʻi i ka carbamazepine, pono ke hoʻohaʻahaʻa ʻia ka nui o ka lāʻau antiepileptic i hōʻike mua ʻia a hiki ke hoʻopau ʻē ʻia. Hiki i ka hoʻopoina koke i nā waiwai o ka carbamazepine e hiki ke hoʻowalewale i ka makehewa epileptic. Inā pono e hoʻokuʻi koke i ka hoʻōla ʻana, pono e hoʻoneʻe i ka mea maʻi i kekahi lāʻau lapaʻau antiepileptic ma lalo o ke ʻano o ka lāʻau lapaʻau i hōʻike ʻia i kēlā me kēia hihia (no ka laʻana, ka lawelawe iā Diazepam iv a i ʻole pololei, a i ʻole paha phenytoin i hōʻeha iv).

Nui nā hanana i ka hoʻomau, ke nānā ʻana a me / a i ʻole ka hōʻemi ʻana i ka mea ʻai, nā koi a me / a i ʻole ka hanu i loko o nā pēpē hou a ko lāua mau māmā i lawe ai i ka carbamazepine e hui pū me nā anticonvulsants ʻē aʻe (aia paha kēia mau kūmua he hōʻike na ka haʻalele kapa ʻana i nā pēpē. Ma mua o ka koho ʻana i ka carbamazepine a i ka wā o ka mālama ʻana, pono ke aʻo ʻana i ka hana o ka ate, ʻoi aku hoʻi i nā poʻe maʻi e loaʻa nei i ka mōʻaukala o ka puʻupaʻa, a me nā maʻi maʻi maʻi. I ka mea o ka hoʻonui ʻana o nā pehu ʻōpū o nā maʻi a i ka wā e kū mai ai ka maʻi hōʻola ikaika, pono e hoʻokuʻu koke ʻia ka lāʻau. Ma mua o ka hoʻomaka ʻana o ka hoʻōla, pono ia e aʻo i ke koko koko (me ka helu ʻana o nā platelets, reticulocytes), ka nui o ka hao ma ka serum koko, kahi hōʻike ʻano urine, ka pae ʻana o ka urea i ke koko, he electroencephalogram, ka hoʻoholo ʻana o ke kuhi ʻana o nā electrolytes i loko o ka serum o ke koko (a me ka wā maʻamau i ka wā mālama, no ka mea. hiki i ka uluʻana o ka hyponatremia). Ma hope iho, pono e nānāʻia kēia mau hōʻailona i ka malama mua o ka mālama ʻana i ka hebedoma, a laila ʻo ka mahina.

I ka hapa nui, ʻo ka hoʻohaʻahaʻa palaki a mau paha i ka pelela a me / a i ʻole e helu sela koko kaila ʻaʻole he harbinger o ka hoʻomaka ʻana o ka anemia aplastic a i agranulocytosis. Eia nō naʻe, ma mua o ka hoʻomaka ʻana o ka hoʻōla, ʻo ia hoʻi ma ka manawa o ke kaʻina hana e mālama ai, e pono ai nā hoʻokolohua o nā maʻi lapaʻau e pili ana, me ka helu ʻana o ka helu o nā platelets a i ʻole reticulocytes, me ka hoʻoholo ʻana i ka pae o ka hao ma ka serum koko. ʻAʻole pono ka holomua asymptomatic leukopenia o ka haʻalele ʻana, eia naʻe, pono ke hoʻokaʻawale ʻia ke ʻano inā loaʻa ka leukopenia holomua a leukopenia holomua, i hele pū ʻia e nā maʻi maʻi o kahi maʻi maʻi.

Pono e hoʻoneʻe koke ʻia ka Carbamazepine inā ʻike ʻia nā maʻi hypersensitivity a i ʻole nā hōʻailona, e hōʻike ana i ka hoʻomohala ʻana i ka maʻi Stevens-Johnson a i ʻole kahi maʻi o Lyell. ʻO ka hoʻonaninani a nā ʻili kino (neʻe iki ʻia a maculopapular exanthema paha) e nalowale i loko o kekahi mau lā a i ʻole hebedoma paha, me ka hoʻomau ʻia ʻana o ka mālama ʻia a ma hope paha o ka hōʻemi ʻana (e ʻike pono ʻia ka mea maʻi e ke kauka i kēia manawa).

ʻO ka hiki ke hoʻokaʻawale i nā ʻōkuhi e nānā pinepine ʻia nei, e noʻonoʻo pono i nā mea maʻi, a i nā mea maʻi ma nā ʻōpio, hiki i ka hoʻomohala ʻana i nā ʻehaʻeha a i ʻole ʻōkuhi psychomotor.

I kekahi mau hihia, mālama ʻia me nā lāʻau antiepileptic i hoʻopili ʻia me ka manaʻo o nā ho'āʻo suicidal / pepehi suicidal. Ua hōʻoia ʻia kēia ma ka meta-analysis o nā hoʻokolohua hoʻokolohua maʻamau me ka hoʻohana ʻana i nā lāʻau antiepileptic. Ma muli o ka ʻike ʻana o ka hopena o ka hoʻāʻo ʻana e hoʻāla i ka hoʻohana ʻana i nā lāʻau antiepileptic i ʻike ʻole ʻia, ʻaʻole hiki ke hoʻokuʻi ʻia ko lākou hanana i ka mālama ʻana o nā mea maʻi me ka hemo Finlepsin ®. Hoʻomaʻamaʻa ʻia nā mea maʻi (a me nā limahana e pili ana i ka pono o ka mālama ʻana i ka puka o nā manaʻo suicidal / hana suicidal a, inā ma ke ʻano ke nānā ʻana, e ʻimi e nānā koke i nā lāʻau lapaʻau.

Malia paha i ka hānai kāne a me / a i ʻole ka spermatogenesis pūpū, akā naʻe, ʻaʻole i hoʻokū ʻia ka pilina o kēia mau maʻi me ka caramazepine. ʻO ke ʻano o ke koko intermenstrual me ka hoʻohana pinepine ʻia ʻana i nā maʻi contraceptives waha. Hiki i ka Carbamazepine ke hoʻopilikia i ka hilinaʻi o nā ʻōpū ʻawaʻawa, no laila, e pono nā wahine o ka hānau ʻana i nā ala hou o ka pale ʻana i ka wā o ka mālama ʻana. Hoʻohana wale ʻia ʻo Carbamazepine ma lalo o ka mākaʻikaʻi maʻi.

Pono e hōʻike i nā poʻe maʻi e pili ana i nā hōʻailona o ka hikiʻole i ka huakai, a me nā hopena mai ka ʻili a me ka puʻuwai. Hoʻomaopopo ʻia ka mea maʻi e pili ana i ka pono e ʻike koke i kahi kauka inā he mau hanana maikaʻi ʻole e like me ke kuni, ka ʻehaʻeha, ka ʻūhā, ka ʻōpala o ka mucosa waha, ka mea kūpono ʻole o ka bruises, ka hemorrhage ma ke ʻano o ka petechiae a purpura.

Ma mua o ka hoʻomaka ʻana i ka hoʻōla ʻana, ʻōlelo ʻia aku kahi hōʻike ophthalmic, me ka nānā ʻana o ka waihona kālā a me ke ana ʻana o ka pēpē intraocular. I ka hihia o ke kuhikuhi ʻana i ka lāʻau lapaʻau i nā mea maʻi me ka piʻi ʻana o ka intraocular hoʻonui, e koi ʻia ka kiaʻi mau ʻana i kēia hōʻailona.

ʻO nā maʻi me nā maʻi cardiovascular koʻikoʻi, nā poho o ka ʻōpala a me nā huehue, a me nā poʻeʻelemakule e kuhikuhi pū ʻia i nā palapala haʻahaʻa o ka lāʻau. ʻOiai ka pilina ma waena o ka hopena o ka carbamazepine, ʻo kona manaʻo a me ka hoʻomau ʻana a me ke kūpaʻa ʻana he mea liʻiliʻi loa ia, akā naʻe, maikaʻi ka hoʻoholo maʻamau ʻana i nā pae o ka carbamazepine i loko o kēia mau kūlana: me ka piʻi nui o ka piʻi ʻana o ka hoʻouka ʻana, no ka hōʻoia ʻana inā ke lawe maikaʻi nei ka mea maʻi i ka lāʻau. i ka wā hāpai, i ka mālama ʻana i nā keiki a i ʻole nā ʻōpio, me ka mea i manaʻo ʻia i ke kīpī ultiple ai '.

I ka wā o ka mālama ʻana me ka hāleʻa Finlepsin ®, ke kauoha ʻia nei e hōʻole ʻole i ka inu ʻawa.

ʻO ka wehewehe ʻana i ke ʻano dosage, ka ʻano

ʻO nā papa Finlepsin he kaila a puni, he kihi convex ma kekahi ʻaoʻao, he chamfer no ka ʻoluʻolu lawenaʻa i ka hapalua, me ke kala ʻula hoʻi. ʻO ka mea hana nui o ka lāʻau lapaʻau ka carbamazepine, ʻo kona waihona i loko o hoʻokahi papa he 200 mg. Eia kekahi, ʻo kona mea pono e kau pū ʻia ai nā mea hoʻohui hoʻohui, kahi i loaʻa:

ʻO ka lāʻau ʻo Magnesium.
Gelatin
ʻO ka cellulose Microcrystalline.
ʻO ka sodium Croscarmellose.

Hoʻopili ʻia nā papa ʻaina Finlepsin i kahi pūʻulu blister o 10 mau ʻāpana. Aia ka pahu pepa kahi 5 blisters (50 papa), a me ke kuhikuhi no ka hoʻohana ʻana i ka lāʻau lapaʻau.

ʻO ka hoʻohana kūpono, dosage

Kuhi ʻia nā papa Finlepsin no ka hoʻoponopono waha (waha waha) i ka manawa a ma hope o ka pāʻina. ʻAi ʻia lākou a holoi ʻia me ka wai nui. ʻO ke ʻano o ke kaʻina o ka lāʻau lapaʻau a me ka uku ʻana ma luna o nā hōʻike a me ke ʻano o ka mea maʻi.

ʻO Epilepsy - ua ʻoi ʻia e hoʻohana i ka lāʻau e like me ka monotherapy. I ka hanana ʻo nā anticonvulsants o nā hui pharmacological i hoʻohana mua ʻia a i ʻole e hoʻohana ʻia i ka manawa e kuhikuhi ai i nā papa Finlepsin, hoʻomaka ka pākana ma ka liʻiliʻi loa. Inā hele ʻoe i ka dosage, pono ʻoe e lawe i ka wā o ka hiki, ʻoiai ʻaʻole hiki iā ʻoe ke pāpālua i ka nui. No nā pākeke, ʻo ka dosage mua o 200-400 mg (1-2 papa), a laila hoʻonui i ka hoʻonui i ka hopena i kahi hopena therapeutic i makemake ʻia. ʻO ka lāʻau mālama mālama he 800-1200 mg i kēlā me kēia lā, mahele ʻia i 2-3 mau poloka. Pono e uku ʻia ka nui o kēlā me kēia lā nui i ka 1.6-2 g. No nā keiki, e hilinaʻi ana ka dosage i nā makahiki. No nā keiki i hoʻonui ʻia i nā makahiki 1-5 - 100-200 mg me ka ulu mālie o 100 mg i kēlā me kēia lā a hiki i ka hopena hoʻomehana kiʻekiʻe kūpono ʻo ia hoʻi, ʻoi aku ka 400 mg, 6-12 mau makahiki - ʻo ka inikua mua loa he 200 mg i kēlā me kēia lā me ka hoʻonui hou ʻana i 400- 600 mg, 12-15 mau makahiki - 200-400 mg me ka hoʻonui pinepine ʻana i 600-1200 mg.
Neuralgia Trigeminal - ke kau mua nei ka nui ma lalo o ka 200-400 mg, hoʻonui pinepine ia i 400-800 mg. I kekahi mau hihia, ua lawa ka 400 mg e hōʻemi i ka nui o ka hōʻeha.
ʻO ka hoʻoneʻeʻana i nā waiʻona, e mālama ʻia ana ka mālama ʻana ma kahi kau o ka haukapila - ʻo ka nui o ka hana ma ka lā he 600 mg i kēlā me kēia lā, ka mea i hoʻokaʻawale ʻia i 3 mau pona. Inā kūpono, hiki ke hoʻonui ʻia i 1200 mg i ka lā. Lawe ʻia ka lāʻau lapaʻau ʻokoʻa lohi. Ke ʻae ʻia ka hoʻohana ʻana i nā ʻano lāʻau ʻē aʻe no ka mālama ʻana i nā hōʻailona no ka haʻalele ʻana.
ʻEha ka maʻi maʻi i ka neuropathy diabetes - ʻo ke awelika o ka awelika o kēlā me kēia lā he 600 mg, ma nā kūlana kūʻokoʻa e piʻi aʻe ana i 1200 mg i kēlā me kēia lā.
ʻO nā mea hoʻohālikelike Epileptiform, ʻo ka hoʻomohala ʻia e hōʻike ʻia e ka sclerosis lehulehu - 400-800 mg hoʻokahi i ka lā.
ʻO ka pale a me ka mālama ʻana i nā maʻi psychosis - ʻo ka helu mua a me ka mālama mālama ʻia he 200-400 mg i kēlā me kēia lā, inā pono, hiki ke hoʻonui ʻia i 800 mg i kēlā me kēia lā.

ʻO ka lōʻihi o ka papa o ka papa hana me nā papa Finlepsin i hoʻoholo ʻia e ka neʻe ʻana o ke kauka.

Nā hiʻohiʻona o ka hoʻohana

Ma mua o ka kuhikuhi ʻana i nā papa Finlepsin, heluhelu pono ke kauka i nā ʻōmua no ka lāʻau a hoʻokaʻina i nā ʻano o nā hiʻohiʻona o ka hoʻohana pono.

Hoʻomaka ka Monotherapy me kahi lāʻau lapaʻau me ka uku liʻiliʻi ma mua, e hoʻonui pinepine ana a hiki i ka hopena therapeutic ke loaʻa.
Me kahi koho pilikino o ka make ʻana o ka therapeutic dos, ke noi ʻia nei e hoʻoholo ʻia kahi hana o ka lāʻau o ka kūpaʻa ʻana o ka lāʻauamaama i loko o ke koko.
ʻOiai e lawe nei i nā papa Finlepsin, ʻaʻole i hoʻoponopono ʻia ke ʻano o nā mea suicidal i ka mea maʻi e pono ai ka nānā ʻana e kekahi kauka.
ʻAʻole ia e hōʻike i ka hoʻohui ʻana i ka lāʻau lapaʻau me nā lāʻau hiamoe a me nā meaʻeha, me ka ʻole o ko lākou hoʻohana ʻana no ka mālama ʻana i nā hopena hōʻemi i loko o ka maʻi palaka.
Ke kuhikuhi nei i nā papa Finlepsin i ka wā e hoʻohana ai i nā anticonvulsants i waho, e hoʻemi iki ʻia ko lākou dosage.
E pale aku i ke ʻano o ke ala o ka lāʻau lapaʻau, pono ka mālama ʻana i nā ʻoihana hoʻonaninani no ka hana hana o ke akepaʻa, ʻāʻā, a me nā koko peripheral.
Ma mua o ka kuhikuhi ʻana i nā papa Finlepsin, ua hōʻike ʻia e hoʻokō i kahi hoʻopaʻa noiʻina holoʻokoʻa me nā hoʻokolohua o ke koko (biochemistry, hoʻopaʻa kulana ʻoihana), urine. A laila e hana hou i kēia mau kikoʻī.
He mea nui ia e hoʻomalu i ka nui o nā kelela o ka nui o ka nui o ke koko ma ke ʻano o ke ala lōʻihi o ka lāʻau lapaʻau.
I ka poʻe maʻi maʻi, ma hope o ka hoʻomaka ʻana e lawe i nā papa Finlepsin, hoʻonui ʻia ka nui o ka hōʻike ʻana i ka puhaka (latent) psychosis.
ʻO kahi kipi momona i loko o ke kāne me ka infertility pōkole ma muli o ka hoʻohana ʻia ʻana o ka lāʻau lapaʻau ʻaʻole i kāpae ʻia, i nā wahine - ke ʻano o ke kahe intermenstrual.
I ka hoʻomaka ʻana o ka papa hana o ka lāʻau lapaʻau, me ka hoʻonaninani ʻana i kēlā me kēia manawa i loko o kāna papa, kahi noiʻi o ka hana hana o ke kino o ka hihiʻo.
ʻOiai e hoʻohana ana i nā papa Finlepsin, ʻaʻole i ʻōlelo ʻia ka ʻona.
Hiki ke hoʻohana ʻia ka lāʻau lapaʻau no nā wahine hāpai i ka wā ma hope o ke koho ʻana i kauka no nā kumu lāʻau koʻikoʻi.
Hiki i ka mea hana pono ke hana ke hoʻopili me nā lāʻau lapaʻau o nā hui lapaʻau ʻē aʻe, i ʻike pono ʻia e ke kauka ma mua o kāna koho.
ʻOiai he hopena kūpono ka lāʻau lapaʻau i ka hana o nā hana o ka nupepa, a laila, i ke kūpaʻa o kona hoʻohana, ʻaʻole hiki ke hiki ke kūpono i nā hana me nā mea weliweli, i hui pū ʻia me ka pono o ka wikiwiki o ka hopena psychomotor a me ka neʻe ʻana o ka makaʻala.

Loaʻa nā papa ʻaila Finlepsin i nā lāʻau lapaʻau ma nā kau lāʻau. I mea e pale ai i ka hoʻolālāʻana o nā hōʻeha a me nā hopena olakino maikaʻi, ʻaʻole ia e pono e hoʻohana iā lākou iho.