Pehea e hoʻohana ai i ka lāʻau lapaʻau Lozap AM?

Hypersensitivity o kekahi o nā lāʻau o ka lāʻau.

ʻLelo ʻia a me ka wā o ka umauma.

He makahiki a hiki i 18 mau makahiki (ʻo ka maikaʻi a me ka palekana o ka hoʻohana ʻole ʻia).

Hoʻohana maʻalahi me ka aliskiren a i ʻole nā ​​aliskiren e loaʻa i nā mea maʻi i ka poʻe maʻi me ka maʻi mellitus a me / a i ʻole hana molopole i loaʻa ʻole (GFR ma kahi o 60 ml / min / 1.73 m2) (e nānā i KAʻOHU ANA MA ʻ OTH me nā MEDICINES).

Ka hopena hōʻeha o ka hana ate (ʻaʻohe ʻike me ka hoʻohana ʻana).

Loaʻa i ke ala wai kaila hema ma waho (e.g., stenosis aortic koʻikoʻi).

ʻO ka hāʻule ʻole o ka hemodynamically kū ʻole ma hope o ka maʻi myocardial hoʻonā.

Hoʻohana i nā mea maʻi me ka hana renal impaired (clearance creatinine ma mua o 20 ml / min) a i ʻole nā ​​mea maʻi ma ka hemodialysis.

Ka hana lāʻau lapaʻau

ʻO nā papa o ka lāʻau lapaʻau ka ʻelua mau mea hana i ka hoʻohui ʻana o Lozap AM me kahi hana hoʻohui o ka hana e hoʻomaikaʻi ai i ke kahe koko (BP) i ka poʻe maʻi me ka haʻi o ka hypertension (AH): potassium losartan, he angiotensin II receptor antagonist (ARA II), a me ka amlodipine, he mea blocker ' e neʻeneʻe ana nā 'calcium kalepa (BMCC).

Nā hopena hopena

Mai ka pūnaehana pili ʻana

ʻO ka hemahema: nāwaliwali, kaʻeha ma ka ʻaoʻao o ka umauma, ka umauma ʻeha, kahi manaʻo o ka wikiwiki wikiwiki, perema peripheral.

Mai ka gastrointestinal tract

ʻO ka hemahema: kaʻeha ma loko o ka ʻōpū, dyspepsia, nausea, reflux esophagitis.

Ma ka ʻāpana o ka ʻili a me ke kiko

ʻOhiwa: ka ʻāʻī o ke ʻili (ʻōmaʻomaʻo), urticaria (laulā).

Mai ka naʻau

ʻO kaʻeha: palpitations.

Mai nā moku

ʻO kaʻeha: ka huki o ka maka, a hypotension orthostatic.

Mai ka pūnaehana hanu, umauma a me nā ʻōpū mediastinal

ʻO ka lohe loiloi a me nā maʻi labyrinthine

Mai ka pūpū a me ka ʻihi

Nā ʻōlelo kikoʻī

I nā mea maʻi me ka hoʻokiʻu ʻana i ka BCC (no ka laʻana, ka loaʻa ʻana o ka mālama ʻana me nā dosis nui o ka diuretics) a i ʻole he stenosis aortic koʻikoʻi, hypotension symptomatic e kū mai. Pono e hoʻoponopono ʻia ia mau ʻano ma mua o ke koho ʻana iā Lozap AM a hoʻomaka i ka mālama ʻana me kahi haʻahaʻa o ka hopena o ka hopena.

E hoʻokuʻu i ke ʻano a me ka ʻano

Hoʻohana ʻia ka lāʻau lapaʻau ma ke ʻano o nā papa kiʻi ʻoniʻoni kiʻi: biconvex, oblong, dosage o 5 mg + 50 mg - kokoke ke keʻokeʻo a keʻokeʻo paha, ma kahi ʻaoʻao me ke kahakaha "AT1", ka pāʻuʻu o 5 mg + 100 mg - ʻulaʻula a i ʻole ʻulaʻula, ma ka i ka ʻaoʻao hoʻokahi i kahakaha ai me "AT2" (10 pcs. i kahi blister, 300 pcs. i loko o kahi bole plastik, i loko o kahi pūpū pepa 1 a i ʻole 3 blisters, a i ʻole 1 pahu a me nā kauoha no ka hoʻohana ʻana iā Lozap AM).

Pākaukau 1 papa:

• mau mea hana: umlodipine camsylate - 7.84 mg (kahi hoʻohālikelike o ka amlodipine ma loko o kahi nui o 5 mg), pāhare pāpale losartan - 50 mg a 100 mg,
• Nā kumuhana hou: sodium carboxymethyl starch, butylhydroxytoluene, microcrystalline cellulose, povidone K30, mannitol, magnesium stearate, crospovidone,
• kaila palani: hyprolose, talc, hypromellose, titanium dioxide, ʻoi aku me ka helu ʻana o 5 mg + 100 mg - nā mea hoʻohuihui huina lāpine ka melemele a me ka hao wili.

Lapaʻau lāʻau

ʻO Lozap AM - kahi lāʻau lapaʻau hypotensive hui pū me kahi lōlani hāpana palaka pehu (BMCC) a me kahi antagonist receptor II ʻĀpono (ARA II). E like me nā hopena o nā haʻawina i lawe ʻia ai nā mea hana olakino, ʻo Lozap AM i loko o ka nui o ka 5 mg + 50 mg a me ka 5 mg + 100 mg ka bioequivalent i ka hoʻohana pū ʻana i nā ʻōhua kūpono o ka camsylate amlodipine a me ka pāhare losartan ma ke ʻano o ka hoʻomākaukau ʻokoʻa.

Loaʻa ʻia iā ia nā papa Lozap AM, i loaʻa ai i ka camsylate amlodipine i loko o kahi pākaʻi o 5 mg, nā bioequivalent i nā papa melemate amlodipine i loko o ka hopena like.

Ke hana o ka hana o ka lāʻau Lozap AM

ʻO nā mea hana o Lozap AM - amlodipine (BCC) a me losartan (ARA II) i kahi hana hoʻohui no ka hana e pili ana i ka hoʻoikaika ʻana i ke kahe koko (BP) i loko o nā maʻi i nā maʻi me ka hypertension arterial (AH). Hoʻopili ʻo Losartan i ka hopena vasoconstrictor o ka angiotensin II a me ka hoʻokuʻu ʻana o ka ald testosterone hope loa i ka hoʻoneʻe ʻana i ka paʻa ʻana o ka angiotensin II i ka ʻĀina AT.₁. ^ E Ha yM. Wahi a Amlodipine e pili ana i nā vasodilators o nā hāpila peripheral a hana pololei i nā kahe lamulene o nā paia o nā kīʻaha koko, e hōʻemi ana i ko lākou pale pākōkē a me kahi hoʻokahe i ke koko.

Hōʻike ʻo Angiotensin II i kahi hopena vasoconstrictor (vasoconstrictive) i ka hopena, a ʻo ia ka hana nui o ka ʻōnaehana renin-angiotensin-aldosterone (RAAS) a me kahi mea nui pathophysiological no ka maʻi hypertension. Hoʻohālikelike i nā ʻĀwapa AT₁hoʻopaʻa 'ia i loko o nā kōpala o nā māla maemae o nā kīʻaha koko, nā ʻōpū, nā kelepaʻi adrenal a me ka puʻuwai, angiotensin II hāʻawi i ka vasoconstriction a me ka hoʻokuʻu i ka aldosterone i loko o ke kahe wai. Eia kekahi, hoʻonāukiuki kēia hāmeʻe i ka ulu ʻana o nā pūpū mākeke palupalu.

ʻO Losartan, kahi lālā o ka hui o nā ʻoniʻoni kūmole o ARA II (AT₁nā mea hoʻonaʻauao), hōʻike i ka hana kiʻekiʻe i ka wā e lawe ʻia ai i ka waha. ʻO kēia mea a me kāna hana ʻano pahu pahu kūmole (E-3174) i loko o ka vitro a ma vivo e kāohi i nā hopena koʻikoʻi nui o ka angiotensin II, me ke ʻano o ke ala a i ʻole ke kumu o kona synt synt. Hoʻopili paʻa ʻo Losartan i ka AT₁-eʻo ia hoʻi, ʻoiai ʻaʻole ia e kāohi a ʻae ʻole paha i nā mea hoʻoponopono o nā ʻoniʻoni a me nā kahawai kīkohu e hoʻoponopono ana i ka hana o nā ʻōnaehana cardiovascular (CCC). Eia nō hoʻi, ʻaʻole e pili ka mea hana i ka hana o ka angiotensin e hoʻohuli ana i ka enzyme (ACE) - kininase II, nāna e hoʻoiho i ka bradykinin. No laila, ʻaʻole pili pili ka hopena o losartan i nā hopena i hoʻopili ʻia i ka blockade AT.₁nā mea komo (me ke ʻano o ka edema).

ʻO Amlodipine kahi kumu o ka dihydropyridine, kahi antagonist o nā calcium calcium a BMCC paha, e pale aku ai i ke komo ʻana o ka transembrane kaomi ma loko o nā cardiomyocytes a me nā kekela hoʻonaninani vascular pae momona. Hiki ke loaʻa i nā kumu o ka hōʻike hoʻokolohua i hiki i kēia mea ke hiki ke hoʻopaʻa i nā mea i hoʻolalelale i nā kanikani kalepa lohi me nā dihydropyridine a me nā pūnaewele e hoʻopaʻa ai i nā dihydropyridine. Hoʻopili wale ʻia ʻo ʻAlodipine i ke kahe ʻana o ka calcium ma o nā membrane, e hoʻopiʻi ana i nā aila ʻoi aku ka momona ma mua o nā pū me myocardial. ʻAʻole hoʻopili ka mea i ka mea serum i ka pae o ka calcium ma ke koko.

ʻO Losartan, e like me amlodipine, e hoʻohaʻahaʻa i ke koko i ka hopena ma o ka nāwaliwali o ka pale kūila. Ka hoʻonāukiuki o ka ulu ʻana o ka calcium ma loko o ka puna a me ka hoʻohaʻahaʻa ʻana i ka hopena vasoconstrictor i hoʻoulu ʻia e ka hana o ka angiotensin II nā hana hoʻohui.

Losartan (nā hopena lapaʻau hou aku)

Hoʻopili ʻo Losartan i ka piʻi nui o ka systolic (DBP) a me ka diastolic (DAD) i ke koko kaʻi ma muli o ka hoʻonā o ka angiotensin II. Ke hiki aku nei i ka pae kiʻekiʻe (C_max) losartan i ka plasma ma hope o ka lawe ʻana i kahi hapa o 100 mg, ke piʻi ʻia ka hopena o ka angiotensin II e pili ana i ka 85%, a ma hope o 24 mau hola - e 26-39%, ia manawa, ma hope o hoʻokahi.

Ke kāohi nei i ka hana renin e ka angiotensin II (pane ʻino), hoʻopau ʻia e ka losartan, hana i ka hoʻonui ʻana o ka hana plasma renin (ARP) hana, e hana ana i ka hoʻonui ʻana o ka plasma angiotensin II pae. I loko o kahi wiki he 6 wiki o 100 losartan o nā mea maʻi ma nā mea maʻi me ka hypertension a hiki i ka manawa C hiki_max aia ka nui o ka hoʻonui ʻana o ka plasma i ka pehu o ka angiotensin II ma 2-3 mau manawa, a i kekahi mau kūlana ke kiʻekiʻe aʻe, ʻoi aku hoʻi me kahi papa o ka lā 14 mau lā. Eia nō naʻe, ʻo ka hopena antihypertensive a me ka emi ʻana o nā pae aldosterone plasma i nānā ʻia ma hope o 2 a me 6 mau pule o ka mālama ʻana, e hōʻike ana i kahi blockade maikaʻi o nā ʻalemuna neʻe o ka angiotensin II. Ma hope o ka pau ʻana o ka hoʻomalu ʻana o ka hoʻokele losartan, hoʻemi ʻia ka piʻi ʻana o ka angiotensin II a me ARP i nā lā 3 i nā mua.

Ke hoʻohālikelike nei i nā hopena o losartan ma loko o ka 20 o 100 a me 100 mg me ka mana o kahi mea hoʻoweliweli ACE, loaʻa ia i ka losartan, ma muli o kahi ʻano hana kūikawā, ua kāohi i nā hopena o ka angiotensin I a me II me ka hoʻopi ʻole ʻana i ka bradykinin. Ua hoʻopaʻa ʻia ka inhibitor ACE e pane aku i ka angiotensin I a hoʻonui i ka nui o nā hopena i hoʻoiho ʻia e ka hana bradykinin me ka ʻole o ka hoʻololi ʻana o ka paʻakikī o ka pane i ka angiotensin II, ka mea i hōʻoia i ka hopena pharmacodynamic ma waena o ka inhibitor ACE a me losartan.

ʻO ka hopena antihypertensive o losartan, ke kiʻekiʻe o ia mea a me kāna hana koʻikoʻi i ka plasma e hoʻonui me ka hoʻonui nui o ka lāʻau. ʻO nā losartan a me kāna metabolite hoʻoikaika i ka hopena hypotensive.

Wahi a nā ʻike noiʻi i loaʻa, kahi i komo ai nā kāne olakino, me ke kaʻi ʻana i ka waha o losartan ma ke ʻano o 100 mg ma ke ʻano paʻakai kiʻekiʻe a paʻakai ka paʻakai, ʻaʻole i pili ka waiwai i ka glomerular filtration rate (GFR), hapa hapa filtration, a me ka kaila o ka plasma renal maikaʻi. Ua hōʻike ʻo Losartan i ka hopena natriuretic, ʻoi aku ka nui o kaʻai paʻakai pākahi, a alakaʻi pū ʻia hoʻi i ka mahuahua o ka hoʻōla ʻana o ka urinary acid e nā keiki.

I mua o proteinuria (ma ka liʻiliʻi he 2 g / 24 mau hola) i nā mea maʻi me ka maʻi maʻi maʻi, me ka ʻole o ka maʻi diabetes, e loaʻa ana ka losartan ma kahi o ka 50 mg no 8 mau wiki me ka hoʻonui nui o ka maʻi i kēlā lā i kēia lā e 100 mg, ua hoʻoemi ka hōʻemi i ka proteinuria (ma o 42%). fractional excretion ʻo albumin a me ka immunoglobulin G (IgG). I nā poʻe maʻi o kēia hui, ua hōʻemi ʻia nō hoʻi ka hapa o ka filtration a ua paʻa pū ka GFR.

ʻO nā mea maʻi i ka wā postmenopausal me hypertension i lawe i ka 50 mg o losartan i kēlā me kēia lā no 4 wiki ʻaʻole i hōʻike i ka hopena o ka lāʻau lapaʻau i nā pae o nā prosticlandins systemic and renal (PG).

ʻO ka lāʻau lapaʻau i lawe ʻia ma mua o ka ʻai (ma kahi ʻōpū ʻole), i nā lā o nā lā a hiki i ka 150 mg, ʻaʻole i kumu i ka nui o nā loli i ka nui o ke kaila o ka triglycerides, ka nui o ka kolamu (Chs) a me nā lipoproteins kūloko kiʻekiʻe (HDL), a ʻaʻole hoʻi i hoʻopilikia i ke kiʻekiʻe o ka glucose i loko o ke koko. Hāʻawi ka hana o ka ʻaina i ka hōʻemi o ka pae serum o ka wa uric i loko o ke koko (ma lalo o 0.4 mg / dl) ka mea i mālama ʻia i ka wā lōʻihi.

I loko o kahi aʻo 12 mau hebedoma e pili ana i nā mea maʻi me ka haʻalele o ka ventricular hema o ka papa hana II II - IV e like me ka helu ʻana o ka New York Association of Cardiology (NYHA) e loaʻa ana i nā diuretics a me / a glycosides cardiac, ua hopena ka hopena o losartan i nā lā maʻamau o 2.5, 10, 25. a me 50 mg me ka hopena pletebo. ʻO ka lāʻau lapaʻau i nā waihona o 25 a 50 mg hōʻike i ka hana neurohormonal maikaʻi a me ka hana hemodynamic i loko o ke aʻo ʻana. Ua hoʻonui ʻo Losartan i ka mākeke cardiac a ua hōʻemi ka nui o ka malege i ka nui o nā pulillary pulmonary, a me ka hōʻemi ʻana o ka puʻupuʻu peripheral vascular resistance (OPSS), i hōʻemi ʻia ka nui o ke koko a me ka puʻuwai naʻau (HR). I kēia mau maʻi maʻi, ua loaʻa ka ulu ʻana o ka hypotension arterial. ʻO nā hopena neurohormonal kahi i emi iho i ke kahe o ke koko o norepinephrine a me aldosterone.

Amlodipine (mau hopena lapaʻau hou)

ʻO ka hoʻohana ʻana o ka amlodipine i nā dosis therapeutic i loko o nā mea maʻi me ka maʻi hypertension e alakaʻi i ka vasodilation, a ma muli o kahi kaohi o ke kahe o ke koko i nā kūlana hoʻopunipuni a kū. ʻAʻole hele ʻia kēia hopena hypotensive o ka hana ikaika me nā loli koʻikoʻi i ka nui o ka puʻuwai a i ʻole nā ​​level catecholamine plasma me ka mālama lōʻihi. ʻOiai ʻo kahi lawelawe intravenous (iv) kahi o ka amlodipine i hōʻike i ka hoʻohaʻahaʻa i ke koko a me ka hoʻonui ʻana i ka holo ʻana o ka naʻau i ka wā e aʻo ana, ʻoi ka hoʻokuʻi ʻana i ka waha o ka lāʻau ʻaʻole i hopena i ka loli nui o ka puʻuwai a i ʻole ke koko i ka poʻe maʻi me ka hoʻokaʻeha koko maʻamau a me ka angina pectoris.

E pale aku i ke ʻano o ka hoʻomanawanui waha ʻana i ka amlodipine hoʻokahi manawa i ka lā, ua ʻike ʻia kona hopena antihypertensive ma kahi o 24 mau hola. ʻO ka pae plasma o ka hana ikaika i ke koko e hoʻoponopono me ka hopena hypotensive ma ka maʻi ʻōpio a me nā poʻe ʻōpio. Nā mea hōʻike o ke hoʻohaʻahaʻa i ke koko i ka wā e hoʻohana ai i ka amlodipine e hoʻoponopono pū ʻia me ka paʻakikī o kona hoʻonui e ʻike ʻia ma mua o ka mālama ʻana. I ka poʻe maʻi me DBP 105–114 mm Hg. ʻAniā. (AH o ke kaumaha hōʻeha) i nānā ʻia i kahi hopena antihypertensive ma kahi o 50% nui aʻe ma mua o nā mea maʻi me kahi DBP o 90-104 mm Hg. ʻAniā. (AH o kaʻeha iki). I mua o ke kahe koko maʻamau i nā maʻi, ʻaʻole i hoʻopaʻa ʻia nā loli nui.

I ka poʻe maʻi me ka hypertension e kū i ke kua o ka hana maʻamau, ka hoʻomalu ʻana o ka amlodipine i loko o ka hopena therapeutic i ka pale ʻana i ke kahe koko o nā puʻupaʻa, hoʻonui i ka holomua o ka plasma renal a hoʻonui i ka GFR, me ka ʻole o ka hoʻololi ʻana i ka hapa filtration a i ʻole proteinuria.

I nā mea maʻi e lawe ana i ka amlodipine, me ka hana maʻamau o ka ventricular, nā ʻāpana hemodynamic o ka naʻau ma ka hoʻomaha a i ka wā e hoʻomaʻamaʻa ʻia ana i ka nui o ka nui o ka nui o ka ʻōpū o ka cardiac me ka loli nui o ka hoʻonui ʻana i ka pume ma ka hoʻomaka ʻana o ka hoʻolaha o ke koko i ka lua o ka ventricle hema, a i ʻole ka nui o ka ventricle hema / hope DBP. Wahi a ke loiloi o nā ʻāpana hemodynamic, ʻaʻole i hōʻike ʻia ka mea ikaika i nā inika therapeutic i ka hopena inotropic maikaʻi ʻole i nā mea hana olakino olakino, ʻoiai ke hui pū me nā β-blockers. Ma ka manawa like, ua hōʻike ʻia nā hopena like i nā mea maʻi me ka puʻuwai naʻau i ka manawa uku a i ʻole nā ​​mea maʻi maʻi inā hoʻohana nā lāʻau lapaʻau me ka hopena inotropic maikaʻi i haʻi.

ʻAʻole i hoʻopilikia ʻia e ka amlodipine ka hana ʻana i ka hoʻokele ʻana o nā Atrioventricular (AV conduction) a i ʻole ka hana sinoatrial node i loko o nā mea hana olakino. I ka / i ka hoʻomaka ʻana o ka lāʻau lapaʻau ma loko o kahi maʻi o 10 mg me ka angina stabil stabil, ʻaʻole i hoʻopilikia nui ka AH a me ka H-V conductivity a me ka hoʻihoʻi ʻana o ka sinus node ma hope o ka pacemaker. Loaʻa nā hopena like i loko o nā poʻe maʻi e lawe ana i ka amlodipine i hui pū me β-blockers. Ma nā noiʻi i nā mea maʻi me ka hypertension a i ʻole ka angina pectoris me ka hui pū ʻana o ka amlodipine me β-blockers, kahi hopena i hiki ʻole i ke kumu o ka electrocardiogram (ECG) i mālama ʻole ʻia. I ka poʻe maʻi me ka pectoris angina, ʻaʻole i pili ka hoʻohana ʻana i ka amlodipine i ka waena o ka ECG a ʻaʻole i kumu i kahi kiʻekiʻe o ka palani AV.

Lapaʻau lāʻau

Ma hope o ka lawelawe waha, ua hoʻopili maikaʻi ʻia a hoʻomanawanui ʻia i ka hopena o ka pau mua ma o ka pūpū me ka hoʻokumu ʻana o kekahi metabolite carboxylated kūlohelohe a me nā metabolites keu. No losartan i loko o ka papa papa, he bioavailability o kahi ʻōnaehana e pili ana i ka 33% kahi ʻano. Losartan a me kāna hana metabolite hōʻea i nā awelika Cmax waiwai 1 a me 3-4 mau hola ma hope o ka hoʻokele ʻana, kēlā me kēia. ʻAʻohe ʻai nui i ka hopena koʻikoʻi ma o ka pona o ke konohala o ka puna.

Me nā protein o ka plasma (ʻo ka hapanui me ka albumin), ʻo losartan a me kāna hana metabolite e paʻa ai i lalo o 99%. Ka Hoʻolaha Mahele (V_{e d}) ʻO losartan ka 34 pā. Wahi a nā noiʻi holoholona, ​​ʻaʻole hiki ke komo i ka pili o ke koko-lolo (BBB). ʻAʻohe mea hōʻiliʻili i nā minamina o ka losartan a me kāna mea nui i ka wā e hoʻohana ana i ka lāʻau lapaʻau ma kahi hoʻokahi o 100 mg hoʻokahi i kēlā me kēia lā.Ma muli o ke kaʻi waha waha o losartan i nā inika a hiki i ka 200 mg, ʻo ka mea a me kāna metabolite hoʻoikaika e hōʻike i ka lineac pharmacokinetics.

Me ka limu a i ʻole ka hoʻohana ʻana a losartan, ma kahi o 14% o kona maʻi ma ka biotransformed i loko o ka metabolite hoʻoikaika. Ma hope o ka lawelawe waha a i ʻole ka hoʻokele iv o 14 C o losartan (i ʻōlelo ʻia me ka carbon radio carbon), hoʻāla ʻia ka plasma plasma radioactivity ma o ka lilo ʻana o losartan a me ka huahana ikaika o kāna metabolism. Ma ka awelika, 1% o nā kānaka i aʻo ʻia i hōʻike i ka liʻiliʻi o ka hoʻololi ʻana i ka losartan i kahi metabolite ikaika. I ka hoʻohui i ka mea o ka wā i ka wā o ka hoʻololi o ka metabolic o losartan, ua hoʻokumu ʻia nā mea nui a ka nui o nā metabolitori biologically kūkaʻi ma muli o ka hydroxylation o nā kaula butyl ʻaoʻao, a me ka lua o ka lua - N-2-tetrazole-glucuronide.

ʻO ka wehe i ka plasma o ka losartan a me kāna metabolite hoʻoikaika e like me 600 a me 50 ml / min, a me ka renal - e pili ana i ka 74 a me 26 ml / min, ma kēlā. Ke lawe ʻia ma ka waha, ua hoʻohana ʻia ka losartan e nā ʻōpū ma kahi loli ʻole e pili ana i ka 4% o ka nui o ka maʻi a ma ke ʻano o ka metabolite hoʻoikaika - e pili ana iā 6% o kēiaʻano. ʻO ka hoʻokō o losartan a me kāna hana hoʻonaninani i ka plasma e hoʻoemi polyexponentially me ka hopena hope o ka hapalua-ola (T_1/2) ma kahi o 2 a 6-7 mau hola, kēlā Hoʻopili ʻia ʻo Losartan a me kāna metabolite e nā ʻōpū a ma waena o nā ʻāpana me ke hua bile. Ma hope o ka hoʻokō ʻana o waha i ka losartan 14 C i nā kāne, ua ʻike ʻia ka awelika o 35% o ka radioactivity i ka urine a me 58% i nā nati, ma hope o ka hoʻomalu iv ivie o ka mea nui o 43% o ka radioactivity i ka urine a me 50% i nā mea hānai.

I ka hypertension i ka wahine, ʻo ka plasma ka manaʻo o losartan he 2 mau manawa ma mua o kēlā mau kāne. Loaʻa nā moka o ke metabolite ikaika i nā kāne a me nā wahine. Eia naʻe, ʻaʻole he koʻikoʻi ka hakahaka ʻo kēia pharmacokinetic.

Me ka hoʻokolohua waha ʻana o ka amlodipine i nā inanin therapeutic, nānā kāna Cmax ma hope o 6-12 mau hola. ʻO ka bioavailability kūpono pololei loa 64-90% o ka waha waha. ʻO ke kūlohelohe o ka amlodipine ke kūʻokoʻa o ka inu ʻana i ka meaʻai.

I loko o ka wā aʻo, ua loaʻa i nā mea maʻi me ka hypertension ma kahi o 93% o ka neʻe ʻana i ka amlodipine e hoʻopaʻa ai i nā protein plasma. Me ka hoʻohana ʻana i kēlā me kēia lā, ʻike ʻia ke ʻano o ke kikowaena (Css) o ka amlodipine i ka plasma ma hope o 7-8 lā.

Ma kahi o 90% o ka amlodipine ka mea i kālai ʻia i loko o ke akepaʻa i nā metabolites hema ʻole, ma kahi o 10% o kēiaʻano e excreted i hoʻololi ʻia e nā keiki, a me 60% i ke ʻano o ka metabolites.

Hoʻokuʻu ʻia ka Amlodipine mai ka plasma i nā lua he lua, ka hopena hope T_1/2 ʻokoʻa paha mai 30 a 50 mau hola.

Lozap AM, nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana: ke ʻano a me ka helu ʻana

Lawe ʻia nā papa pā Lozap AM ma ke alo, me ke ʻano o ka manawa ʻai, me ka nui o ka wai. Hiki ke hoʻohana ʻia ka lāʻau lapaʻau me ka hui pū me nā lāʻau hana antihypertensive.

ʻO ka poʻe maʻi i hōʻole ʻole i ka loaʻa o ke kaohi koko ke kaomi ʻana i ka wā e hoʻohana ai i ka losartan a i ʻole amlodipine e like me ka lāʻau monotherapy hiki ke hoʻololi i ka hui hoʻohui o Lozap AM. E lawe i ka lāʻau lapaʻau 1 manawa i kēlā me kēia lā no 1 papa, ʻo ka nui loa ka nui 5 + 100 mg hoʻokahi i kēlā me kēia 24 hola.

Kuhi ʻia ka Lozap AM 5 + 50 mg no nā maʻi e loaʻa ʻole i ka kaohi koko wailua i ka wā e hoʻohana ai i ka amlodipine ma ke ʻano o 5 mg a i ʻole losartan ma kahi o ka 50 mg ma monotherapy.

Noi ʻia ʻo Lozap AM 5 + 100 mg no nā poʻe maʻi i ʻike ʻole i ka ʻoka o ke koko i ka wā e hoʻohana ai i ka losartan ma ke kō o 100 mg a i ka lāʻau lapaʻau Lozap AM 5 + 50 mg. ʻO ka poʻe maʻi e lawe ana i ka amlodipine a me ka losartan e like me nā lāʻau kūʻokoʻa e hiki ke hoʻololi i Lozap AM (e loaʻa ana nā koina o ka amlodipine a me losartan) e hoʻonui ai i ka pili ʻana i ka mālama ʻana.

Inā e lawe nui ʻia ʻo Lozap AM i nā poʻe maʻi me ka hoʻēmi ʻia BCC, me ka hana ʻoki ʻole a i ʻole nā ​​mea maʻi maʻi, a laila ma mua o ka hoʻomaka ʻana i ka mālama ʻana me ka lāʻau hoʻohui pū me nā ʻōmole paʻa o ka amlodipine a me losartan, kahi mea koho ponoʻī o nā ʻōmole o kēia mau mea ikaika e hana.

ʻO nā mea maʻi me ka BCC i hōʻemi ʻia (me ka poʻe e loaʻa ana i ka mālama ʻana me ka diuretics i nā wai kiʻekiʻe) e ʻōlelo ʻia e lawe i ka losartan i kahi ma mua o 25 mg hoʻokahi manawa i ka lā ma ke ʻano he monotherapy, no ka mea, ʻaʻole he dosis a Lozap AM e loaʻa ai ka 25 mg o losartan.

Ke keu

ʻAʻohe ʻike e pili ana i kahi overdose o Lozap AM.

Hoʻolaha ka ʻikepili e pili ana i kahi overdose o ka losartan, ʻoi paha me kēia ʻano, tachycardia a me kahi māhina i hōʻailona ʻia i ke koko, hiki paha ke hele a hiki mai ka bradycardia ma muli o ka hoʻouluʻana parasympathetic. Hoʻonohonoho ʻia ka lāʻau lapaʻau maʻi, ʻaʻole pono nā hemodialysis.

ʻO nā hōʻailona o kahi overdose o ka amlodipine ka nui o ka vasodilation peripheral me kahi nui o ka hoʻokahe nui ʻana i ke koko a me ke ʻano o ke ʻano o ka tachycardia reflex. Aia nā hōʻike e pili ana i kahi hopena hypotensive system lōʻihi a me nā mea koʻikoʻi, me ka pihoihoi me ka hopena hōʻeha. I kahi hihia o ka overdose, inā pono, hoʻonui ʻia ka gastric a me ka charcoal i hoʻolaʻa ʻia. Inā hoʻokomo ʻia kahi hopena kiʻekiʻe loa o ka lāʻau lapaʻau, pono e nānā i nā ʻōhumu ʻana a me nā ʻōhua hemodynamic, a pinepine ʻole ke ana i ke koko. E kūʻē i ke kūkaʻi o ka hiki ʻana o ka hypotension arterial, pono ka ʻana o ka hoʻokele ʻana o nā ʻano wai, pono e hāpai ʻia nā wāwae o ka mea maʻi a pono e hana ʻia nā hana maʻamau e mālama ai i ka hemodynamics. Inā ʻaʻole kūpono nā hana mālama, e kuhikuhi ʻia ka lawelawe ʻana o ka phenylephrine a me nā mea āpau vasoconstrictor hou, e pili ana i ka diuresis a me ka bcc.

Hoʻokuʻu ʻia ka poloka o nā ala kalsi e ka iv infusion o ka calcium gluconate. ʻAʻohe mea maikaʻi ke kaʻina hemodialysis, no ka mea he kiʻekiʻe ka nui o ka amlodipine e kūmole i nā protein plasma.

Hoʻokomo i ka hiki ke lawe i nā kaʻa a me nā mīkini paʻakikī

ʻAʻole i hoʻokō ʻia kahi hōʻike o ka hopena o Lozap AM i ka hiki ke lawe i nā kaʻa a me nā mīkini paʻakikī. Eia nō naʻe, pono e hoʻomanaʻo i ka manawa o ka mālama ʻana i hiki mai nā hopena kūpono ʻole e hiki ke hoʻopilikia i ka wikiwiki o nā hopena psychomotor a me ka ulu.

ʻŌpū a me ka lactation

Hoʻomaʻamaʻa ʻia ʻo Lozap AM i ka wā hāpai a i ka wā lactation. Hiki i nā lāʻau hōʻeha kūpono i ka RAAS ke hōʻeha i ka nui a me ka make i ka pūpū ulu. Ke hoʻoholo nei i ka hāpai ʻana, pono e hoʻihoʻi hou i ka lāʻau. Inā pono, e huli i ka anti antihypertensive therapy me ka lāʻau lapaʻau i loaʻa ke kōkana palekana i hoʻopaʻa ʻia no ka hoʻohana ʻana i ka wā hāpai.

ʻOiai ka mea ʻaʻole i ʻike ka wahine hāpai i ka lawe ʻana iā Lozap AM, ua ʻike ʻia nā haʻawina holoholona preclinical e hiki i ka losartan ke hōʻeha i ka maʻi embryonic a me ka neonatal a me ka make a me ka make. Ua kuhi ʻia ua pili pono ka ʻano o kēia mau ʻano i nā hopena i ka RAAS.

ʻO ka hoʻohana ʻana o ka losartan i ka trimesters lua a me ke kolu o ka hapai e hoʻomāhuahua i ka hana o nā aʻalopona a hoʻonui i ke kau a me ka make o ka wīne a me ka wahine hou. ʻO ka hopena o ka oligohydramnios e pili ana me ka hypoplasia o nā maʻi o ka fetal a me ka deformations o kāna mau kaʻe. ʻO nā hopena kūpono ʻole ma muli o ka losartan i loko o ka mea aloha hou paha e komo pū kekahi hypotension arterial, hypoplasia iwi cranial, anuria, pilikia ʻole, a me ka make. Inā mālama ʻia nā lāʻau lapaʻau e pili ana i ka RAAS ma ka pēpē a me ke kolu o ka hapala o ka hapai, ʻaʻole hiki ke hoʻololi ʻia i ka lāʻau aʻoaʻo hou, pono e ʻike ʻia ka mea maʻi i ka hopena o ka lawe ʻana i kēia mau lāʻau lapaʻau no ka ʻōpio.

ʻO ka hoʻopaʻa ʻia ʻana a lawa pono nā haʻawina o ka hoʻohana ʻana i ka amlodipine i nā wahine hāpai i lawe ʻole ʻia.

Inā ʻike ʻole ʻia ka losartan a me ka amlodipine i ka waiū umauma. Inā pono ʻoe e lawe i ka Lozap AM i ka wā lactation, pono ʻoe e hoʻōki i ka hana maʻi umauma.

ʻAʻohe ʻike e pili ana i ka hopena o losartan i ka ulu momona. Aia nā hōʻike no nā hihia o ka hoʻololi o ka biochemical hoʻololi i ke poʻo sperm, nānā ʻia ma kekahi mau mea maʻi e loaʻa ana iā BMCC. ʻAʻole lawa ka ʻike o ka data noiʻi e loiloi i nā hopena e hiki mai ana i ka amlodipine ma ka hānai.

Hoʻohana i ke wā kamaliʻi

Ua hoʻohana ʻia ka hoʻohana ʻana o Lozap AM i nā keiki a me nā ʻōpio, no ka mea, ʻaʻole i hoʻonohonoho ʻia ka palekana a me ka hopena o ka lāʻau lapaʻau.

ʻO nā wahine hou i lawe aku ka makuahine iā ARA II i ka wā hāpai (ʻo ka losartan) pono e nānā pono ai e kāohi i ka hyperkalemia, oliguria a me ka hypotension arterial. Inā i ʻike ʻia nā hoʻopiʻi luna i luna i kēia mau keiki, ua hoʻākāka ʻia ke ʻano maʻi maʻi e mālama pono i ka poni a me ke koko. Hiki ke koi ʻia i ke koko a i ʻole nā ​​dialysis e pale ai i ka hypotension arterial a me / a i ʻole ke hoʻokolohua pono i ka hana maʻamau.

Me ka hana pūnāwai paʻa ʻole

Ma ka hōʻea o ka pōʻino nui (CC ma lalo o 20 ml / min) a i ʻole ka pono no ka mālama hemodialysis, e lawe ana i ka Lozap AM i contraindicated. No ka poʻe maʻi me ka hana renal moderate, ʻaʻole i ʻōlelo ʻia ka mālama ʻana me ka lāʻau lapaʻau. Pono ʻia ka mālama ʻana e lawe i ka lāʻau no ka stenosis o ka lāʻau ʻokiʻoki hoʻokahi a me ka stenosis bilateral o nā hāmeʻa like ʻole, ka papakū o ka pale ʻana, ke ʻano ma hope o ka hoʻololi ʻana i ka huehue. ʻAʻole pono ia e hoʻoponopono i ka maʻi maʻi i nā mea maʻi me ka hana hoʻopiʻi o ka hana o ke keiki ma ka hihia o CC - 20-50 ml / min.

Me ka hana pūpū hemahema

Ma ka hanaʻino o ka ate nui (ʻoi aku ma mua o 9 mau maka ma ke kaila o ke keiki-Pugh) - ua hui ʻia ʻo Lozap AM, nā mea maʻi me ka hana aho o ka puʻuwai a me ka hōʻemi haʻahaʻa (emi iho ma mua o 9 mau poʻina i ka pēpē Child-Pugh) pono e hoʻohana i kahi mea antihypertensive me ka akahele.

Wahi a nā hōʻike pharmacokinetic i hōʻike i ka nui o ka hoʻonui ʻana i ke kaila losartan i loko o nā mea maʻi me ka cirrhosis, nā mea maʻi me ka mōʻaukala o ka cirrhosis a i ʻole nā ​​hopena hōʻemi ʻeha. Pono lākou i ke koho ʻana o losartan i nā haʻahaʻa haʻahaʻa (25 mg i hoʻokahi manawa i ka lā) i monotherapy.

Ma muli o ka hana nui o ka amlodipine i loko o ka ate, i ka poʻe maʻi me ka maʻi T_1/2 like me na hora 56. Inā e pono e hoʻohana i ka amlodipine i nā mea maʻi me ka piʻi nui o ka hōʻeha o ke akeʻa, hoʻonaninani ʻia nā titration o kona ʻano.

Hoʻohana i ka wā kahiko

Ke lawe nei i nā haʻawina ʻoihana ma nā mea maʻi ma mua o 65 mau makahiki he mau makahiki, ʻaʻole i ʻike ʻia nā hiʻohiʻona e pili ana i ka pono a me ka palekana o ka mālama ʻana ma ka losartan. Mai ka mea maʻi ma waena o ka poʻe maʻi, ma muli o ka hōʻemi o ka mahele o ka amlodipine, ua hoʻonui ʻia ka wahi i lalo o ka pihi o ka paʻa-manawa (AUC) ma ke ʻano he 40-60%, ʻae ʻia ka hoʻomaka ʻana e hoʻomaka me ka wai i kēlā me kēia lā he mau lā he 2.5 mg, akā mai ka manawa ʻO Lozap AM ka nui o 5 mg o ka amlodipine, pono e lawe nā mea maʻi i ka amlodipine e like me ka lāʻau monotherapy.

Hoʻohui nūhou

ʻAʻole i hana ʻia kahi hōʻike o ka pilina o Lozap AM me nā lāʻau ʻē aʻe.

Hiki i nā hopena e pili ana i ka launa pū ʻana o losartan me ka hoʻohana pū ʻana me nā mea lapaʻau a me nā mea lapaʻau hou:

• digoxin, hydrochlorothiazide, cimetidine, warfarin, phenobarbital: ʻaʻohe mau kauka ʻike nui i ʻike ʻia.
• rifampicin: hoʻemi ka nui o ka losartan i ke koko,
• erythromycin: ʻaʻohe hopena koʻikoʻi o nā maʻi i ka pharmacokinetics o losartan i ka wā i lawe ʻia ai i ka waha,
• ketoconazole: ʻaʻohe hopena i ka metabolism o losartan ma hope o kāna hoʻomehana iv a hiki i ka hoʻokumu ʻana o ka metabolite ikaika,
• fluconazole (inhibitor o ka isoenzyme CYP2C9): ke kāohi nei o ka metabolite ikaika o losartan e hoʻemi nei, ʻo ka ʻike pharmacodynamic o ka hui pū ʻana o ka losartan a me nā mea paʻa o ka CXP2C9 isoenzyme ʻaʻole i aʻo ʻia.
• triamteren, spironolactone, amiloride and other potassium-sparing diuretics, pākuhi me ka paʻakai pākili a i ʻole paʻakai pākohu: ʻike ʻia kahi hoʻonui o ka potoma serum
• Hoʻomoe lithium: he mea hiki ke hōʻemi ʻia ka lithium excretion, mālama pono ʻana i ka pae o ka lithium i ke koko pono,
• Non-steroidal anti-inflammatory drug (NSAIDs), me nā konipili cyclooxygenase-2 inhibitors (COX-2): hiki ke hoʻonāwaliwali i ka hopena antihypertensive o ka poʻe maʻi nā maʻi a i nā mea maʻi me ka dehydration, me nā mea e loaʻa nei nā diuretics, me kēia hui pū ʻana, hiki ke hoʻēmi ʻia i ka hana ʻula. , aia pū me ka loaʻa ʻana o kahi hana ʻoi ʻole, ka hui ʻana i nā lāʻau lapaʻau e pono ai ka mālama kūikawā.
• pāwaha pālua o RAAS (ka hoʻohana ʻana i ka ARA II a me ACE inhibitors a renin inhibitor - aliskiren): ka hopena o ka hypotension arterial, hyperkalemia, syncope a me ka hana ʻole o ka hana (a me ke kūleʻa o ka hopena o ka renal) e hoʻonui ʻia inā i hoʻohālikelike ʻia me ka monotherapy, ka mālama pinepine ʻana i ka hana o ke keiki, ka hoʻokaʻina o ke koko a ka paʻa ʻana o nā electrolytes i ke koko.

ʻO nā hopena kūpono e pili ana i ka pilina o ka amlodipine me ka hoʻohana pū ʻana me nā hua lāʻau / nā mea lapaʻau hou:

• digoxin, phenytoin, warfarin, indomethacin: ʻaʻohe hopena i ka paʻa ʻana o kēia mau lāʻau i nā protein plasma koko e like me nā haʻawina vitro,
• cimetidine, antacids e hoʻopili ai i ka magnesium a i ʻole alumina hydroxide, huaʻala kōpele (240 ml): ʻaʻohe hopena maikaʻi loa i ka pharmacokinetics o amlodipine i ka wā e hoʻohana ai i ke ʻano hoʻokahi o ka hopena o ka hopena,
• atorvastatin (ma ke ʻano o 80 mg): ʻaʻohe mau hoʻololi nui ma nā kūlaʻi kākoi ʻoinacrininetic o ka atorvastatin me ka hui pū ʻana o ka amlodipine e hui pū ana ma ka pā o 10 mg.
• sildenafil (hoʻokahiʻano o 100 mg): e kū'ē ana i ke kuʻuna o ke hypertension, ʻaʻole i pā pono nā pharmacokinetics o amlodipine, me kēia hui, kēlā me kēia ʻano o kēia mau mea e hōʻike kūʻokoʻa ai i ka hopena antihypertensive,
• tacrolimus: pono ka hoʻonui ʻana o ka hoʻonui i kona neʻe ʻana i ka plasma, e nānā ʻia ke kiʻekiʻe o kēia mau mea i ka plasma.
• simvastatin (ma kahi o ka 80 mg): i hui pū ʻia me amlodipine ma kahi o 10 mg, ka piʻi ʻana o ka simvastatin e ka 77%, ka pākuʻi o nā lā simvastatin i kēlā me kēia lā ʻaʻole i kiʻekiʻe ma mua o 20 mg,
• dantrolene (iv administration): ka hopena o ka arrhythmia, hina, hyperkalemia a me ka hoʻohaʻahaʻa ʻana i ka nui o ka puʻuwai naʻau;
• cyclosporin: hiki i ka nui o ke neʻe i kona neʻe ʻana, i loko o nā mea maʻi ma hope o ka hoʻololi ʻana i ka pēpē, he piʻi ʻana no Cmin o cyclosporin i ka plasma e pili ana he 40% i ʻike ʻia, i ka wā e hui pū ʻia me Lozap AM, ka nānā ʻana o Cmin cyclosporin e koi ʻia.
• warfarin: ʻaʻohe mea i hoʻonui i ka manawa prothrombin,
• ethanol: ʻaʻohe hopena koʻikoʻi o kona pharmacokinetics i ʻike ʻia,
• itraconazole, ketoconazole, ritonavir (nā mea paʻa ikaika o ka isoenzyme CYP3A4): hiki ke hoʻonui ʻia ka plasma o ka amlodipine, e mālama pinepine ʻia ana i nā hōʻailona o ka hypotension arterial a me ka edema,
• diltiazem (ma ke ʻano o 180 mg), erythromycin (ʻāwili ʻia o ka isoenzyme CYP3A4): i ka wā e hui pū ʻia ana ʻo diltiazem me ka amlodipine ma kahi pākē o 5 mg, he hoʻonui hoʻonui 1.6 i ka AUC o ka hopena inā loaʻa kēia hui i nā poʻe maʻi maʻi me nā maʻi hypertension, i ka wā i hui pū ʻia me ka erythromycin i loko o ke olakino. ʻaʻohe hopena koʻikoʻi ma ka AUC o ka amlodipine, eia naʻe, i nā poʻe ʻelemakule, hiki ke hoʻopaʻa ʻia i kahi loli nui i kona ʻike.
• clarithromycin (inhibitor o isoenzyme CYP3A4): ka hōʻemi o ka hōʻemi o ke kaʻe o ke koko, e mālama pono ʻia ka mālama mālama maʻi.
• rifampicin i hoʻokahe ʻia me ka wort o St. John (inducers o CYP3A4 isoenzyme): ʻaʻohe hopena koʻikoʻi o nā hiʻohiʻona pharmacokinetic o amlodipine i hala; ua ʻōlelo ʻia e kiaʻi mau i ke koko o ke koko.

ʻO nā hui o Lozap AM ʻo Lortenza, Amzaar, Amozartan, Lozartan, Sardip, etc.

Inoa Kūʻai ʻole honua

ʻO Losartan ka inoa honua no ka lāʻau.

Nā antagonist C09DB Angiotensin II i hui pū me BKK.

ʻO Lozap AM kahi lāʻau lapaʻau no ka hoʻohaʻahaʻa i ke koko a hoʻihoʻi i ka CCC.

E hoʻokuʻu i nā palapala a me ka ʻano

ʻO ka lozap kahi līkeke ma kahi ʻāpana keʻokeʻo. Aia kekahi mau ala o ka hoʻokuʻu ʻana, ma muli o ke kahe ʻana o ka mea nui - 12.5, 50, 100 mg.

• nā mea waiwai nui he losartan potassium,
• Microcrystalline cellulose, starch, sodium stearate, wai, crospovidone, silicon dioxide.

Ke kūʻai ʻia nei ka lāʻau lapaʻau ma nā pahu pahu he nui o 3, 6 a 9 paha.

Hoike ʻia ma Lozap AM

Loaʻa nā loiloi e pili ana iā Lozap AM. Hoʻomaopopo ka poʻe maʻi i ka hana kiʻekiʻe o ka lāʻau ke hoʻohālikelike ʻia me Lozap, no ka mea ʻo Lozap AM he ʻelua mau mea ikaika, ua kuhikuhi ʻia no ka hoʻohana ʻana me AH nui a i ʻole me ka hoʻomohala o ka hoʻohui i Lozap. ʻO ka lāʻau lapaʻau, e like me nā loiloi, he hopena maikaʻi loa ia i ka CVS a hiki iā ʻoe ke hoʻokō maikaʻi i ka pī koko.

ʻO ka wehewehe ʻana i ka lāʻau lapaʻau

ʻO Lozap Am kahi hui pūloko e like me nā mea hana ʻelua, ʻo ia hoʻi, kahi paʻani amlodipine kūʻokoʻa kahi camsylate, ʻoi aku ka kiʻekiʻe o ke kūlike i ka amlodipine besylate e hoʻohana nui ʻia. Koho ʻia e nā maʻi kulekele a me nā loiloi maikaʻi e pili ana iā Lozap Am 5 + 100 mg, ua ʻike ʻia, ʻaʻole like me nā lāʻau antihypertensive hou, hōʻike ka lāʻau lapaʻau i ka hopena antihypertensive ikaika loa, aʻo nā hopena pili i ka wā o ka lapaʻau he ʻokoʻa ka maʻamau. Hiki iā ʻoe ke kūʻai iā Lozap Am i kahi lāʻau lapaʻau ma ka hōʻike ʻana i kahi papa kuhikuhi mai kāu kauka.

E hoʻokuʻu i ke ʻano, ka hoʻonohonoho ʻana a me ka pōpoki

ʻO ka lāʻau lapaʻau e hana ʻia e ka hui ʻo Zentiva ma ka puka papa: Lozap Am 5 me 100 mg a i ʻole + 5 + 50 mg, ka helu mua e hōʻike ana i nā kikoʻī o ka camsylate amlodipine, ka lua - ka potassium losartan. Hoʻopili ʻia nā papa i nā palaka o nā ʻāpana he 10 a i ʻole kahi kāleka waiho ʻoki a 300 mau ʻāpana. Ke kumu kūʻai o Lozap Am hiki iā ia ke hilinaʻi i ka paʻa ʻana o nā mea ikaika a me ka pūnaewele olohala kahi i kūʻai ʻia ai ka lāʻau lapaʻau.

Nā hōʻailona no ka hoʻohana ʻana

Kau ʻia ka lāʻau lapaʻau i nā pākeke a me nā keiki mai nā makahiki 6 me ko kēia mau pilikia:

• ʻaina (ke kiʻekiʻe o ke koko),
• ka pale ʻana i ka infarction myocardial,
• arrhythmia, ischemia a me nā maʻi maʻi ʻē aʻe o ka CVS,
• maʻi maʻi i nā maʻi me nā maʻi mellitus.

Ua kuhikuhi ʻia ka lāʻau lapaʻau no ke koko kiʻekiʻe.
Ua kuhikuhi ʻia ka lāʻau lapaʻau no ka maʻi hypertension i nā maʻi me ka maʻi mellitus.
Ua kuhikuhi ʻia ka lāʻau lapaʻau no ka pale ʻana i ka infarction myocardial.

Me ka mālama pono

Hiki iā ʻoe ke lawe i ka lāʻau lapaʻau ma nā liʻiliʻi liʻiliʻi me nā kumu like:

• puʻuwai paʻakikī
• hyperkalemia
• waie ʻole wai-electrolyte,
• hypotension arterial ma nā keiki ma lalo o 6 makahiki.

Hiki iā ʻoe ke lawe i ka lāʻau lapaʻau ma nā liʻiliʻi liʻiliʻi no ka hiki ʻole o ka naʻau.
Hoʻokomo ʻia ka lāʻau i ka wā o ka lactation.
Hiki iā ʻoe ke lawe i ka lāʻau lapaʻau ma nā liʻiliʻi liʻiliʻi me ka hypotension arterial i loko o nā keiki ma lalo o 6 mau makahiki o ka makahiki.

Pehea e lawe ai iā Lozap AM

Lawe ʻia nā papa papaʻaina, me ka manaʻo ʻole o ka hoʻokomo ʻana i ka meaʻai. ʻO ka paona maʻamau he 50 mg i kēlā me kēia lā. Hoʻoponopono ʻia ia ma muli o nā ʻano pilikino o ka mea maʻi. I loko o nā pilikia poli o ka naʻau, ʻo ka mua mua loa he 12.5 mg. I ka nele o nā hopena o ka hopena, e hoʻonui nui ʻia ka 50 mg e hoʻokō i ka hopena kiʻekiʻe.

No ka pale ʻana i ka hoʻoulu ʻana ma ka naʻau ʻelua, e lawe ʻia ka nui o 50 mg i hoʻokahi lā. Hoʻomaʻamaʻa ka Therapy e like me ka mea a ka cardiologist.

Lawe i ka lāʻau lapaʻau no ka maʻi maʻi maʻi

ʻAʻole hiki iā ʻoe ke lawe i kahi maʻi piha i ka manawa mua. Pono e nānā i ke ʻano o ke kino, no laila e noʻonoʻo ʻia e hoʻomaka me 50 mg i kēlā me kēia lā. Me ka lāʻau hou, hoʻonui ʻia ke ʻano iā 100 mg i kēlā me kēia lā. Hiki iā ʻoe ke hoʻohana koke i ka 100 mg a i ʻole 50 mg i 2 mau hoʻonohonoho.

I ka maʻi mellitus, ʻaʻole pono e lawe ʻia kahi papa piha manawa mua.

Hematopoietic mau hui

Ma muli o ka hoʻokomo 'ole kūpono, ka nui a me ka hemahema o ka hao, lithium, a me nā huaora e tupu. No ka mea, loaʻa i nā maʻi he nui - anemia, leukocytosis, etc.

Ma muli o ka hoʻokomo 'ole kūpono, ka nui a me ka hemahema o ka hao, lithium, a me nā huaora e tupu.

ʻO wai nā ʻano o nā lāʻau lapaʻau?

ʻO ka mea mua pono e ʻike ʻoe i ka wai o ka lāʻau ʻo Lozap. ʻO nā pōpō e hōʻemi i ke kahe koko ke pili i ka hui o nā lāʻau antihypertensive.

ʻO nā ʻōlelo i hoʻohana ʻia e pili ana lākou i ka ke kino ma o ka pale ʻana i ka pilina o ka angiotensin 2 me nā ʻenehana receptor. Penei, hele ka maʻamau o ke kaila o ke koko.

He aha kēia mau penikala?

ʻO nā mea hōʻike i nā ʻōlelo kuhikuhi no ka hoʻohana ʻana no nā papa Lozap, kahi a lākou e kōkua ai, penei:

• ke kiʻekiʻe,
• ka hemahema o ka puʻuwai aloha - ua hoʻokomo ʻia ka lāʻau lapaʻau i ka hoʻomohala ākea a pono kona hoʻohana ʻana no nā mea maʻi me ka hoʻomanawanui ʻole i ka hui hoʻoweliweli ACE, me ka hiki ʻole o ka hopena.
• ʻO ka hōʻemi ʻana i ka hopena o ka hōʻike a hoʻonāukiuki paha i ka naʻau a me ka luʻi o ka maʻi ma ka poʻe me ka hypertension a waiho aku i ka ventricular hypertrophy,
• nephropathy i ka maʻi maʻi a me nā poʻe me ka hypertension.

ʻO kekahi ʻano nui o ka lāʻau lapaʻau ka hiki ke hoʻonui i ke kūʻē o ke kino i ka hoʻoikaika kino. Ke pale aku i ka hypertrophy kūwili naʻau mea hoʻohana hou i nā papa Lozap. ʻO nā ʻōlelo e hoʻohana ai ka ʻikepili i ka ʻikepili no kēlā me kēia patula.

Inā ʻoe e ʻimi i nā kauoha i ka hoʻohana ʻana i ka mālama ʻana a ʻike maopopo pehea lā e lawe ai i ka lāʻau lapaʻau mai ke kaomi, a laila hoʻokō ʻia ka hopena o ka hōʻemi ʻana i ka pehu no nā hola 5-6 ma hope o ka hoʻokele ʻana, a laila mālama ʻia ia no kahi lā. Me ka hoʻohana pinepine ʻana i nā papa, loaʻa i kahi hopena paʻa i hoʻokahi mahina ma hope o ka hoʻohana ʻana i nā papa Lozap.

Me ka proteinuria i haʻi ʻia, kōkua ka lāʻau e hoʻopau i ka emi ʻana o ka protein.

Mai ka ʻaoʻao o ka metabolism

ʻO kahi kaulike ole i ka hana metabolism ka mea pinepine loa i ka wā e lawe ana iā Lozap a me nā lāʻau ʻē aʻe i kūpono ʻole i ka losartan.

Hiki ke kūleʻa kona maʻi me kahi overdose a i ʻole ka intolerance kanaka i nā mea o ka pūnaina. Hōʻike ʻia e kahi holo, kala, ʻulaʻula a ka ʻula. I nā hanana pinepine ʻole, e hele a huki paha.

Hoʻolaha ka waipuna

Ke hoʻohana nei i ka lāʻau lapaʻau, pāpā paʻa loa ia i ka inu ʻona, no ka mea pili ʻole ka losartan me ka waiʻona.

Ke hoʻohana ʻia i ka lāʻau lapaʻau, pāpā paʻa loa ia i ka inu ʻona.

Hoʻohana i ka wā hāpai a me ka lactation

Ua papa ʻia ia e hoʻohana i ka lāʻau i ka mea mua a me ke kolu ʻoi aku, no ka mea aia he hoʻomohala ka hopena o ke kino. I ka wā HBV, ʻaʻole ʻōlelo ʻia e hoʻohana i nā lāʻau antihypertensive, no laila ʻaʻole e hōʻeha i ke keiki. Ua hōʻike ʻia kēia noiʻi hiki i ka losartan ke alakaʻi i ka manuahi fema.

I ke ʻano o ka uʻi aʻu e lawe ai?

Ke alakaʻi nei ka maʻi no ka hoʻomohala ʻana i ke ʻano o ka hypertension no kēlā me kēia kanaka e kahi kauka. Nā wale nō i hoʻoholo i ke koho a hiki ke hoʻopau ʻia. ʻAʻole kūʻokoʻa ia e mālama i ka mālama ʻana me Lozap. ʻAʻole i ʻōlelo nā ʻōkuhi no ka hoʻohana ʻana i ka mea e koi ʻia ai ka hoʻohana ʻana, no laila e hāʻawi ʻia ka mālama ʻana i kekahi loea.

Nā ʻano o ka Hypertension

Pehea e lawe ai?

ʻO nā papa Lozap no ke kaohi e like me nā kuhikuhi i ka hoʻohana ʻana, e hōʻike ʻia e inu i hoʻokahi manawa i ka lā, e hoʻomaka ana ka lāʻau maʻi me nā haʻahaʻa haʻahaʻa. Ma mua o ka hoʻomaka ʻana i lāʻau lapaʻau, e hoʻomaʻamaʻa ʻia ka hoʻoponopono ʻana o ka kaulike wai-electrolyte. E like me nā ʻōlelo no ka hoʻomohala ʻana o ka cirrhosis, he ʻae ʻia wale nō nā ʻāpana liʻiliʻi.

Pēlā nō hoʻi e hoʻonui ʻia ka ʻike o ka pāhana i ka poʻe ʻelemakule, no laila, e like me nā ʻōkuhi, ua hoʻokumu ʻia ka hoʻohana ʻana o nā hōʻemi haʻahaʻa loa.

ʻAʻole pili ka lāʻau lapaʻau i ka hiki ke mālama i ka halihali a me ka neʻe ʻana o ka maka - ua hōʻike ʻia kēia ʻano ma nā ʻōlelo aʻoaʻo no ka hoʻohana. Pono e ʻawaʻawa nā papa i ka nui o ka wai o ka wai a ʻaʻohe ona hopena o ka hana i ka hana o ka gastrointestinal tract. Hiki ke inu i ka Lozap ma ka hoʻohaʻahaʻa haʻahaʻa - ʻoiaʻiʻo ʻaʻole, no ka mea e like me nā ʻōlelo i hoʻohana ʻia, manaʻo ʻia no nā poʻe me ka hypertension e hoʻemi i ke koko.

Ma mua o hoʻokahi a ma hope o kahi ʻaina?

I ka manawa e nīnau aku ai pehea e lawe ai iā Lozap ma mua a ma hope o ka ʻai ʻana, pane mai nā kauka ʻaʻole ʻaʻohe ʻokoʻa kumu, ʻoiai, e like me nā kauoha no ka hoʻohana ʻana, lawe ʻia ka lāʻau lapaʻau ma ke ʻano, me ko ka wā o ka ʻaina.

Ua wehewehe nā kauka i ka wā i nīnau ʻia ai iā Lozap, he aha nā dosages i laila, hiki ke hoʻokaʻawale ʻia nā nui o nā hihia i like me nā kuhikuhi no ka lāʻau lapaʻau.

1. Ke hōʻike nei ʻo ia i ka hypertension arterial, pinepine ʻo Lozap i kahi manawa, ʻo 50 ka nui i kēlā me kēia lā he 50 mg e like me ke kuhikuhi ʻana. I kekahi manawa, no ka hana ʻoi aku ka maikaʻi, e pāpālua ʻia ka nui, akā ua lawe ʻia 1 mau manawa.
2. No nā poʻe me ka puʻuwai naʻau paʻakikī, ʻo ka hopena he 12.5 mg hoʻokahi i ka lā. Hoʻonui ia i kēlā me kēia pule i kahi awelika o 50 mg. Pono ka hoʻomanawanui o ka lāʻau a me nā contraindications e like me nā ʻōkuhi.
3. No ka poʻe maʻi e hana ana i ka maʻi maʻi me nā dosis nui o ka diuretics, hoʻemi ʻia ka intake mua i 25 mg i kēlā me kēia lā.
4. I ka poʻeʻelemakule, ʻo ka mea mua ʻaʻole i hoʻoponopono ke kauka i ke alapine maʻamau o 50 mg i kēlā me kēia lā.
5. Ke hōʻike ʻia ka hoʻohana ʻana o ka lāʻau lapaʻau e hōʻemi i ka hopena o ka hōʻike o nā maʻi cardiovascular a pale i ka make ʻana i nā poʻe me ka hypertension, e like me nā ʻōlelo aʻoaʻo, ʻo ke ʻano mua he 50 mg i kēlā me kēia lā. Ma ke kāhea, hoʻonui ʻia ʻo 100 mg.
6. No nā mea maʻi me ka diabetes mellitus a me proteinuria, ʻo ka nui o ka make ma mua o 50 mg i kēlā me kēia lā, e piʻi mālie i ka 100 mg. Akā pono e noʻonoʻo e ke kauka i nā hōʻailona koko.
7. I ka loaʻa o nā maʻi o ka pōpoki concomitant a i ka wā dehydration ma hope o hemodialysis ma luna o ka apparatus, ma hope o 75 makahiki, pono ʻoe e hōʻemi i ka dosage i 25 mg pākahi.

Hiki ke loaʻa nā maʻi āpau a me nā kuhikuhi o ka lāʻau i nā kuhikuhi no ka hoʻohana.

Pehea ka lōʻihi e hiki ai ke hana?

Ke kuhikuhi ʻana i ka lāʻau lapaʻau, nīnau koke nā mea maʻi i ka lōʻihi o ka manawa e lawe ʻia ai ʻo Lozap. Ma hope o ke koho ʻana i kahi kūpono kūpono, e hoʻohana ʻia kona hoʻohana ʻana i kekahi mau mahina a hiki i kekahi mau makahiki. Aia ke kaukaʻi ʻia i kana hana pono.

Inā ʻaʻohe o nā hopena hopena, e hoʻokūkū maikaʻi ka ikaika, a laila ʻaʻole ʻoe e hoʻololi i ka hāmeʻa. Hiki ke hana wale i kahi hoʻomaha i ka mālama ʻana i kahi kauka. Ke hoʻopau ʻia ka lāʻau lapaʻau, hiki i kahi piʻi nui i ke kaomi ka hiki. ʻO ka manawa kūpono no ka lawe ʻana iā Lozap ma ka manawa ua hoʻoholo ʻia e ke kauka.

Pūnaehana

Nā hopena pili i hōʻike ʻia i loko o nā ʻōkuhi no ka hoʻohana a me ka hala wikiwiki ʻana me ka hoʻomohala hoʻomau.

• ʻeha ka ʻōpū
• ʻeha ma loko o ka ʻōpū,
• luhi wikiwiki
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• nā ninia
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• ninini
• lie kanikela
• nā poloka i loko o nā uaua keiki
• hiamoe a hiamoe ʻole
• huhū
• nasalest congestion.

Me ka hoʻohana mau ʻana

Hiki i nā hopena ʻaoʻao o Lozap me ka hoʻohana lōʻihi ke hoʻopili i nā ʻokoʻa āpau a me nā ʻōnaehana, ʻoiai ka hōʻiliʻili ʻana o nā mea lāʻau i loko o ke kino e hele lohi. Hoʻonāukiuki lākou i kēia mau ʻōlelo ʻino:

• lauoho e ulu ana i ka ulu ʻana ma muli o ka hoʻonui ʻana i ka ʻili o ka ʻili a me ka hoʻoneʻe ʻana ma ka palau.
• ulia i nā wahi me ka ʻili o ka ʻili,
• ka hana maikaʻi ʻole i ka hana o ke ʻōnaehana cardiovascular - ʻeha hōʻeha, ka nosebleeds,
• ka hana ʻana i nā hana o ka gastrointestinal tract: flatulence, constipation a me nā maʻi pākuhi, ʻaina makemake ʻole,
• ka luhi ʻana i ke ʻano o ka ʻono a me nā ʻono oki,
• mau ʻōlelo pinepine o ka hopohopo
• nā hoʻomaʻa pinepine ʻana.

He hoʻohālikelike a me ka hoʻohana pinepine ʻana

I ka wā o ka lāʻau lapaʻau, pono ka mea maʻi e nānā i nā mea i inu ʻia e ia i ke kīpī, i hāʻawi ʻia i ko lākou kūlike, ʻoi aku ka maikaʻi o ka nānā ʻana i nā ʻōlelo kuhikuhi no ka hoʻohana. Eia kekahi, ke kūʻē nei nā manaʻo kuhihewa e ka inu ʻana i ka wai inu i ka manawa o ka hoʻohana ʻana i kēia lāʻau lapaʻau.

Hiki nō ke lawe iā Lozap me ka waiʻona - maʻamau pinepine nā poʻe. Ke manaʻo nei kekahi poʻe maʻi e ʻaʻole e hōʻino ka waiʻona i ka wā o ka mālama ʻana a me ka hoʻopiʻi maʻamau ʻana o Lozap a me ka waiʻona.

Hōʻike ʻia nā loiloi o ka poʻe i ʻike i kēlā hopena i kā lākou iho. Ma hope o nā mea a pau, e mau ana ka hopena o ka lāʻau i kekahi lā mai ka manawa o ka hoʻokele ʻana, a no ka hana pono o ka hana i mālama ʻia i kahi papa lōʻihi. Ma kēia hōʻike, ʻaʻole kūpono ʻole ʻo Lozap a me ka waiʻona.

Bisoprolol

ʻO Bisoprolol a me Lozap - ʻae ʻia ka hoʻonāukiuki i ka lāʻau lapaʻau. ʻO kēia mau lāʻau lapaʻau mai nā hui lāʻau lapaʻau like ʻole. E like me nā kuhikuhi i ka hoʻohana ʻana, ʻo Bisoprolol he blocker adrenergic, ka mea nui o ka kaohi o ka puʻuwai puʻuwai, e hōʻemi ana ia.

Lozap - hōʻemi i ke koko. I ka hui pū, ua maikaʻi kēia mau lāʻau lapaʻau i ka hoʻonui ʻana i ke kaumaha me ke tachycardia, arrhythmia, a me ka pono o ka naʻau.

ʻO kēia kahi lāʻau lapaʻau kaulana i hoʻohanaʻia e like me nā ʻōlelo aʻo no ka mālama ʻana i ka maʻi hypertension, me ka hoʻokumu ʻana o ka edema koʻikoʻi ma muli o ka loaʻa ʻole o ka naʻau a i nā kumu ʻē aʻe. ʻO kēia ka diuretic o ka mea, i ka wā hypertensive, e hana ana me kahi vasodilator. Ke kū nei ka nīnau: he mea hiki ke lawe pū pū iā Lozap a me Indapamide.

ʻO Kapoten lāua ʻo Lozap - hoʻopaʻapaʻa hou kā lākou kūlike i ka wā ʻoiai ʻaʻole hiki ke ʻōlelo ʻia he kuhi ʻole lākou.

I kekahi mau hihia, hiki ke kuhikuhi pū ʻia kahi mea hoʻonaninikena receptor i ka neʻe me ka angiotensin e hoʻohālikelike ana i ka lāʻau hōʻuluʻulu enzyme, e ʻae ana i ka hopena hypotensive maikaʻi. Eia nō naʻe, ma ka hoʻomaʻamaʻa, ʻike pinepine nā kauka i ka manawa like me ka lāʻau nei.

Eprosartan

Hiki ke kiʻi ʻia ʻo Eprosartan i hoʻokahi manawa a i kuhikuhi ʻia e nā papa. Me ka hoʻohana pākahi hoʻokahi, hoʻomau ke kūlohelohe a noho mau maʻa i ke ao holoʻokoʻa. Loaʻa ka hopena therapeutic paʻa ma hope o hoʻokahi mau pule o ka hoʻohana maʻamau.

ʻO ka hui like ʻo Eprosartan a me Lozap, akā, i ka like like. Ma kēia hiʻohiʻona, e kū ana ka nīnau inā he mea hiki paha i ka manawa like Eprosartan me Lozap. ʻAʻole pono ʻoe e hana i kēia, no ka mea, ʻaʻole e loaʻa ka hopena ʻelua a ʻaʻole i hoʻonāukiuki i nā hopena ʻaoʻao, i mea, e like me nā ʻōlelo i hoʻohana ʻia, aneane like nā kālā.

Ke hōʻike nei i nā poʻe i lawe i kēia lāʻau lapaʻau

Hiki iā ʻoe ke ʻike i ka nui o nā loiloi maikaʻi o ka poʻe e pili ana i ka lāʻau lapaʻau. Hoʻomaikaʻi ia i ka hoʻonaninani ʻana, hoʻōla i ka hana naʻau a me ka hiamoe, hoʻopau pū i ke kaumaha. Wahi a nā mea maʻi e holo koke ʻo Lozap, akā ʻaʻole i nānā ʻia ka hopena lōʻihi. ʻO ka ʻōlelo i hōʻike ʻia e hopena ka hopena i ka lā, akā i kekahi manawa ke lōʻihi loa o 4 mau hola. Akā inā hōʻemi ʻoe i ka ʻeha a lawe ʻole i ka manawa 1, akā ʻoi aku ka manawa pinepine, a laila lawa ka hopena no 24 mau hola. Hoʻomaopopo ka poʻe maʻi i ka hoʻohana ʻana o kahi haʻahaʻa haʻahaʻa e kōkua i ka hoʻohaʻahaʻa ʻana i nā hopena o nā ʻaoʻao. Akā me kēia ala, ʻo ka hopena ma hope o ka lawe ʻana i ka pil, ʻaʻole e holo i loko o 30 mau minuke, akā i loko o 1.5 mau hola.

Eia kekahi, ʻike ka poʻe maʻi ʻaʻole inu maʻalahi ka inu ʻana iā Lozap ma muli o ka hopena diuretic ikaika, mai laila pinepine nā mea kīwaha e pā ai. Ua hoʻomaopopo pono ʻia kēia e ka poʻe hana. Hōʻike ʻia nā loiloi i nā hihia o ka hōʻā ʻana i ka pō ma ka pō ma hope o ka hoʻomaka ʻana o ka holo ʻana, he mea paʻakikī ke hoʻokaʻawale ʻia ma hope o ke hoʻopau ʻana.

He nui nā analogues a lāʻau lapaʻau paha e like me nā hopena like, he mau hōʻuluʻulu loea kēia o Lozap. Akā i kā lākou aʻoʻana he mau ʻokoʻa, a hiki i ke kauka ke hoʻoholo i ka pehea e kahuli ai iā Lozap.

Ke hoʻohālikelike nei iā Lozartan a me Lozap, ʻo wai ka mea e ʻoi aku ka nīnau i nīnau pinepine ʻia.Wahi a nā ʻōkuhi no ka hoʻohana ʻana, ua hōʻike ʻia nā lāʻau ʻelua no ka hoʻoponopono ʻana o ka hypertension. ʻO lākou nā antagonist reseptor ala angiotensin.

ʻO Lozap lāua ʻo Losartan hoʻokahi a like nō ia, ʻo ka mea ikaika o ka ʻelua o ke ʻano he coincides. Loaʻa nā ʻaina ʻelua i ka hypertension, akā ʻaʻole kēia kumu no ka noʻonoʻo pono ʻana i ka loaʻa ʻana o kekahi me kekahi. ʻO ke kauka wale nō ke hāʻawi i nā ʻōlelo hōʻike kūpono.

Inā mākou e kamaʻilio e pili ana i nā lāʻau lapaʻau o Lozap a i Lorista paha, ʻoi aku ka maikaʻi o lākou, ʻaʻohe ʻano koʻikoʻi. Kūʻokoʻa lākou i nā mea hana a me nā kumu kūʻai. ʻOi aku ka maʻalahi o Lozap, ka mea hoʻomaha e like me nā kuhikuhi no ka hoʻohana.

Ma mua o ka hoʻoholo ʻana iā Valsartan a i ʻole Lozap, ʻoi aku ka maikaʻi, pono ʻoe e hoʻomaopopo i kā lākou mau pōmaikaʻi. ʻO ka pōmaikaʻi o Valsartan ʻo kona ʻano hana kaha dosage, ʻoi loa ia ma ke ala e loli ʻole ai - 83%, a me 13% e nā kuli. Ma kēia hana, ua hoʻākāka pinepine ʻia nā maʻi o nā aʻa a me nā pōpoki, ʻoiai ʻaʻole ia e hoʻohui i kēia mau kino.

Wahi a nā ʻōlelo kuhikuhi no ka hoʻohana ʻana, e hoʻoneʻe ʻia ka lāʻau lapaʻau e hoʻokahe i nā kīʻaha koko a me nā puna wai. Pēlā e hoʻomohala a mālama i ka paipai ʻana. E koho iā Valsacor a i ʻole Lozap - ʻoi aku ka ʻoi aʻe, pono ʻoe e ʻike i nā ʻokoʻa ma waena o kēia mau huahana: ʻo Valsacor he mea hoʻohālike pololei o Valsartan, ka mea e hana ana i ka lula like ʻole me ka hoʻopono ʻole i ka ate a aneane me ka hoʻopā ʻole ʻana i nā hina. Eia kekahi, ʻo kāna hopena hypotensive he mau pūʻulu kiʻekiʻe.

Ma muli o ke kumukūʻai kiʻekiʻe o kēia huahana, makemake nui nā maʻi i ka mea i ʻoi aku i ka maikaʻi ma mua o Valz a i ʻole Lozap. No laila, ʻo Valz kahi lāʻau lapaʻau hypotensive, he mea pani o nā mea hoʻokipa o ka AT1 i ka angiotensin II. Wahi a nā ʻōlelo kuhikuhi, ʻaʻohe ona contraindications e hoʻopili ai me nā lāʻau ʻē aʻe, ua aʻo ʻia kāna hopena hypotensive me ka nui loa o ka ʻōlelo, ke lawe ʻana i ka lāʻau i ka hopena maikaʻi loa o ka hōʻike ʻia o ka maʻi.

ʻO ka lāʻau Antihypertensive, inhibitor ACE. Ke pane nei i ka nīnau, ʻo wai ka mea e ʻoi aʻe, ʻo Lozap a i ʻole Enalapril, pono ʻoe e wehewehe e ʻānai ʻia ka lua o ka hōʻemi ma mua o ka nui. ʻO ke kumu kūʻai o Enalapril, ma kahi ʻē aʻe, ʻoi aku ka maʻalahi. Akā e pono e noʻonoʻo i ka, e like me nā mea hoʻopaʻa ACE a pau, pinepine ia i ka umauma ʻaoʻao.

He lāʻau lapaʻau antihypertensive kēlā, e like me ke kauoha, e hōʻemi i ke kahe koko nui me ka ʻole o ka piʻi ikaika o ka puʻuwai puʻuwai. ʻOiai ʻo ke kumukūʻai nui loa o Enap, nā kauka, i ka wā e pane ana i ka nīnau o ka mea ʻoi aku ka maikaʻi, ʻo Enap a i Lozap, e kuhikuhi aku i ka mea mua no ka komo.

Lisinopril

ʻO kēia lāʻau lapaʻau mai ka hui o nā inhibitor ACE. ʻO kaʻoi aku ka mea maikaʻi, ʻo Lozap a i Lisinopril paha, he nīnau maʻamau i ka poʻe maʻi. ʻO ʻelua mau lāʻau me ke hypertension e hana like, akā like me nā ʻōlelo aʻoaʻo, lilo ka ʻōpū ma kahi ʻaoʻao o Lisinopril. ʻO ke kumukūʻai e pili ana i ka like.

ʻO kēia he mea lapaʻau ikaika, kahi pale o ACE, e like me nā kauoha, ʻo ka lōʻihi o ka hopena e hoʻomau nei no kahi lā. ʻO ka mea hana nui a Diroton ʻo lisinopril, a ʻokoʻa ka hopena o nā lāʻau ʻelua. ʻO ia ke kumu, i maopopo ai iā Diroton a i Lozap, ʻoi aku ka maikaʻi, pono ʻoe e ʻike e ke kaukaʻi nei nā kauka iā Diroton Lozap me ka intolerance lisinopril.

Hale Pūnaewele

I mea e ʻike ai i ka mea ʻoi aku ka maikaʻi - Lozap a i Prestarium paha, pono ʻoe e hoʻomaopopo i kā lākou mau ʻokoʻa. ʻO ka Prestarium kahi mea ACE inhibitor, e like me nā ʻōnaehana i hoʻohana ʻia no nā ʻano maʻi koʻikoʻi o ka hypertension, no nā pilikia koʻikoʻi o nā kīʻaha koko a me ka puʻuwai, ʻoiai e hōʻemi ana i ka puiihoi ʻana. Ua haʻahaʻa ʻia kona kumukūʻai. Akā ʻaʻole iki o Lozap e hōʻike i ka hopena o ka hopena o ka pūʻulu inhibce ACE - ʻōpala maloʻo.

ʻO Noliprel ka lāʻau hui pū. I loko o kāna palapala hana, aia nā manawa 2 mau mea ikaika o perindopril a me indapamide, e pili ana i ke kino i ka manawa like, no laila e hana maikaʻi ana ia.

Hoʻomaopopo ka hopena lāʻau lapaʻau mau loa ma hope o hoʻokahi mahina o ka hoʻohana a ʻaʻole i hele ʻia e ka piʻi nui o ka puʻuwai. Ma kēiaʻano, pili ka pane i ka nīnau o ka mea ʻoi aku ka maikaʻi - Lozap a i ʻole Noliprel mea maopopo.

E ʻōlelo ʻoiaʻiʻo e ʻike ʻo Concor a Lozap ʻo ka mea maikaʻi loa o lākou. Hoʻomaopopo pinepine ʻia lākou e inu i ka manawa like i ka paʻakikī. ʻO Concor kahi beta-blocker ʻaʻole wale nō e hoʻohaʻahaʻa i ke koko, akā e hoʻomaikaʻi nō hoʻi i ka helu o ka puʻuwai. E like me nā kauoha, lawe ʻia ʻo Lozap i ke kakahiaka, a ʻo Concor - i ke ahiahi. Koho ʻia ka hui kūikawā e ke kauka e like me ke ʻano a me nā hiʻohiʻona o ke kino o ka mea maʻi.

ʻO ka Equator kahi hui lāʻau antihypertensive hui pū ʻia. E pane i ka nīnau ʻO Equator a i ʻole Lozap - ʻoi aku ka maikaʻi, e pono e ʻike ʻia: a hoʻohālikelike ʻia me Equator, Lozap i liʻiliʻi a contraindications e like me nā kuhikuhi no ka hoʻohana.

Hōʻike ʻia ka lāʻau Lozap AM i kahi hopena ikaika loa, ʻo ka mea loaʻa iā ia nā 2 kaha hana: losartan potassium a me amlodipine. He mea kūpono kēia hana a hoʻohana ʻia e like me nā ʻōkuhi i hōʻike ʻia i nā pilikia paʻakikī i ka mea ʻaʻole i kōkua ʻo Lozap a i ʻole ua lilo i mea hoʻohui i ke kino.

Nā kuleana a me nā kūlana e waiho ai

Ke mālama nei iā Lozap Am, pono ia e nānā i kahi mahana o ke keʻena ʻaʻole he 30 kiʻekiʻe o Celsius. ʻO ka iwakāluakūmāhā malama o ke ola o ka lāʻau lapaʻau, ma hope o kēia manawa ua pāpā ʻia ka lāʻau lapaʻau e hoʻohana ʻia a pono e hoʻokuʻu ʻia. Hiki iā ʻoe ke kauoha i ka hāʻawi ʻana iā Lozap Am ma Moscow a me kahi o ka pūnaewele ma kā mākou pūnaewele.

Ke noi no ka hana renal haukapole

Ma muli o nā noiʻi pharmacokinetic, ua hoʻohuli ʻia ka hopena o ka lawe ʻana iā Lozap, hiki ʻole ke ulu lāʻau hou i ka ulu ʻana, no laila, pono i ka poʻe me ka hana renal impalired e hoʻohana i ka pākuʻi liʻiliʻi ma hoʻokahi i hoʻokahi lā. Inā ʻaʻole i mālama ʻia, hiki ke hoʻopau wale i ka palani, ke alakaʻi i ka hoʻololi ʻana i nā keiki.

Hoʻohui hui like ʻole

Ua papa ʻia ia e hoʻohana iā Lozap i hui pū me ka diuretics, ka mea i loaʻa i ka hōʻemi o ka pāhare, no ka hoʻohālike me Amiloride, Spironolactone, no ka mea e hiki ke kiʻi ʻia ka hyperkalemia.

Lā ʻia ka hoʻohana ʻana iā Lozap i hui pū me ka diuretics, kahi e loaʻa ai ka ʻohi o ka paʻakai.

ʻO nā hui e koi ana i ka mālama

Me ka hoʻohana like ʻana o ka lāʻau anti-inflammatory non-steroidal me ka hui, e hoʻemi ana ka hopena o ka lazartan, no laila e lilo kahi kina ʻana o ke ʻano o ka hypertension, me he mea lā i ka lāʻau plaseta plasebo (non-medicinal).

Inā, no kekahi kumu, ʻaʻole hiki ke lawe ʻia ʻo Lozap, hiki ke hoʻololi ʻia me nā lāʻau o nā hopena like:

• ke kahua nei me ka hydrochlorothiazitis - Angizar, Amlodipin, Amzaar, Gizaar, Lorista, Lozap plus (nā lāʻau lapaʻau Lūkia),
• ke kau nei i ke kukui - Kandekor, Kasark, Hizart-N,
• ʻO ka mea nui o ka telmisartan ʻo Mikardisplyus, Telpres, Talmista.

Ma mua o ka hoʻohana ʻana i kahi analog, pono ʻoe e ʻōlelo i kahi loea. No nā poʻe maʻi maʻi me ka intolerance, ua hoʻololi ʻia ʻo Lozap iā Amlodipine.

ʻO Amlodipine kekahi o nā kaona o ka lāʻau Lozap AM.
ʻO Kasark kekahi o nā analogues o ka lāʻau Lozap AM.
Mikardisplyus - kekahi o nā kaona o ka lāʻau Lozap AM.

Cardiologists

Svetlana Aleksandrovna, Phlebologist, Rostov-on-Don

Kūleʻa wau i nā maʻi he nui e lawe iā Lozap, no ka mea e hoʻopilikia pono ana ia i ka CVS a me ka hoʻohaʻahaʻa i ke koko, e pale ana i nā maʻi lehulehu. Wahi a nā ʻike noiʻi, ʻo kēia kekahi o nā lāʻau lapaʻau maikaʻi loa e kū'ē i ka hypertension.

Sergey Dmitrievich, cardiologist, Irkutsk

Ke kau nei wau i nā poʻe maʻi he nui ma hope o ka hana ʻana e mālama pono ai i ke kaomi maʻamau, e kāpae i nā hōʻeha o ka hypertension.

ʻO ka ʻōlelo aʻo Lozap AMC

Olga Vasilievna, 56 makahiki, Kurganinsk

Ua lawe wau iā Lozap ma mua o 5 mau makahiki. Ua loaʻa iaʻu kahi maʻi diabetes 2. Hoʻomau piha ʻia ka lāʻau lapaʻau, maʻamau mau ka paʻakikī, ʻaʻohe ʻano hopena.

Ivan, 72 makahiki, Moscow

Kākaukau ʻia e ka maʻi cardiac no ka pale ʻana o ka hōʻeha ʻana o ka naʻau, no ka mea loaʻa iaʻu ka maʻi ʻalā coronary. ʻOiai e kōkua ana, loaʻa iaʻu ke 30 mau makahiki ʻōpio.

ʻO nā huahana māmā

Kauka pinepine nā kauka i ka lāʻau Lozap. ʻO nā huahana a me nā mea e pili ana i ka lāʻau lapaʻau ke hoʻohana ʻia i ka hihia i pili i ke kino.

1. ʻO kahi Vazotens kahi hake o nā papa Lozap. Aia ia ka mea like me ke kiko like, a me kahi papa inoa like. Ua hoʻohana ʻia ka hoʻohana ʻana i ka lāʻau lapaʻau no nā wahine hāpai a i ka wā lactation, me nā keiki ma lalo o ka makahiki 18.
2. ʻO blocktran kahi kahaki no Lozap i hana ʻia ma Lūkia. ʻO ia ka waiwai like, no laila ke hoʻohana pinepine ʻia kona hoʻohana ʻana ma kahi o Lozap no ka hoʻomaʻamaʻa ʻana o ka puʻuwai naʻau a me ka hypertension.
3. ʻO Lozarel kahi hoʻohālikelike o Lozap. ʻO ka lahui ka mea like a kū like a i ka hoʻomo ʻōlelo like ʻole. No laila, hoʻonohonoho nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana i nā lāʻau lapaʻau me ka papa inoa o nā hōʻike a me nā hopena maikaʻi.

He aha e hoʻololi ai inā ʻaʻole paʻa ʻo Lozap i ka ikaika?

Pehea e hoʻololi ai iā Lozap inā ʻaʻole i paʻa ka ikaika o ka nīnau pinepine inā hiki i ka hoʻōla ʻana ke hoʻokō i kāna mau hana. Hoʻololi nā poʻe akamai i nā lāʻau lapaʻau'ē aʻe me nā hōʻailona like e like me nā kuhikuhi no ka hoʻohana.

Hoʻolaha pinepine kēia ma muli o ka neʻe ʻana o ka hypertension e holomua ana a lilo ka lāʻau i ka hopena i lilo i mea ʻole ʻole. ʻEkolu mau ʻaoʻao e hoʻoponopono i kēia pilikia:

• ka hoʻonui ʻia ʻana
• ka wā e koho ai ka hui hoʻohui ʻana, ʻo ia hoʻi, ka hoʻohui ʻana o nā lāʻau lapaʻau hou,
• ka loli ʻana o ka huahana i hoʻohana ʻia.

Hāʻawi ʻia kahi papa inoa o lākou ma luna. No ka hoʻohālikelike ʻia ʻana o kēlā me kēia maʻi o ka maʻi i ka mea maʻi a me nā ʻōnaʻo no ka lāʻau lapaʻau, koho ke kauka i ke ʻano o nā hana no ka mālama ʻana a mālama pono i kona ʻano i kekahi kūlana.