Nā kuʻina o ka lāʻau lapaʻau > Nā lāʻau lapaʻau

Nā hōʻike o ka lāʻau lapaʻau, hiki ke hoʻololi ʻia i loko o nā hua o ka hopena ma ke kino, ka hoʻomākaukau ʻana i loaʻa i hoʻokahi a i ʻole nā mea like i hana like. Ke koho ʻana i nā unuhi, e noʻonoʻo wale ʻaʻole i kā lākou kumukūʻai, akā no ke aupuni o ka hana a me ka maikaʻi hoʻi o ka mea hana.

ʻO ka wehewehe ʻana i ka lāʻau lapaʻau
Ka papa inoa o nā mea kikoʻī a me nā kumukūʻai
Hoike Mai

ʻO ka wehewehe ʻana i ka lāʻau lapaʻau

Baeta - He exenatide (Exendin-4) he agonist o ka hopena o ka pōkō ʻāpoʻe o ka glucagon e like me ka amidopeptide 39-amino. ʻO nā incretins, e like me ka ponaide-like ponaida-1 (GLP-1), e hoʻomaikaʻi i ka huna ʻana i ka glucose i ka glucose, hoʻomaikaʻi i ka hana β-cell, kaohi ʻana i ka hoʻokaʻawale me ka hoʻokahe nui ʻana o ka gastric ma hope o ko lākou komo ʻana i ka kaila ākea mai nā ʻōpū.

He exenatide kahi mimetic mimetin ikaika e hoʻonui ai i ka huna ʻana i ka glucose o ka glucose a loaʻa nā hopena hypoglycemic i loaʻa i ka incretins, e hoʻomaikaʻi ana i ka mana glycemic i nā mea maʻi me ka maʻi diabetes type 2.

ʻO ka mahele o ka waikawa amino o ka exenatide mahele like me ka pakanui o ke kanaka GLP-1, ma muli o ia mea i hoʻopaʻa ʻia a hoʻoulu i nā mea hoʻokipa GLP-1 i loko o nā kānaka, e alakaʻi ana i ka synthesis-hilinaʻi nui o ka glucose a me ka huna ʻana o ka insulin mai ka pancreatic cells-cells me ka komo ʻana o ka cyPic AMP a me / a i ʻole nā mea ʻē aʻe intracellular i hōʻailona. ala. Hoʻonohonoho ka Exenatide i ka hoʻokuʻu ʻana o ka insulin mai nā β-cell i mua o ka piʻi ʻana o ka glucose kiʻekiʻe.

Hoʻolaha ka Exenatide i ka hana kemika a me nā hana pharmacological mai ka insulin, derivatives sulfonylurea, D-phenylalanine derivatives a me meglitinides, biguanides, thiazolidinediones a me alpha-glucosidase inhibitors.

Hoʻonui ka Exenatide i ka mālama glycemic i nā mea maʻi me ka maʻi type 2 no ka mea hana i kēia mau hana.

ʻO ka huna ʻia o ka glucose o ka glucose: ma nā kūlana hyperglycemic, hoʻomaikaʻi ka exenatide i ka huna ʻana i ka glucose o ka glucose mai ka pancreatic β-cells. Ua kāpae kēia mea huna huna i ka hoʻōla ʻana o ka glucose i ke koko a ke hoʻokokoke nei ia i ka maʻamau, a laila e hōʻemi ʻia ka hopena o ka hypoglycemia.

ʻO ke ʻano mua o ka pane ʻana i ka insulin: ka hiʻu ʻana o ka insulin i ka wā 10 mau minuke mua loa, ka mea i kapa ʻia ʻo ka "hoʻomaka mua o ka pane ʻana i ka insulin", ua paʻa ʻia i ka poʻe maʻi me ka maʻi mellitus type 2. Eia kekahi, ʻo ka nalowale o ka pae mua o ka pane ʻana o ka insulin he ʻemi o nā hana o ka hana β-cell i ka maʻi diabetes type 2.

Hoʻomaka hou ka mālama ʻana o ka exenatide i ka mua a me ka lua o nā lua o ka pane ʻana i ka insulin i nā maʻi maʻi me ka maʻi type 2.

ʻO ka huna ʻana o Glucagon: i nā mea maʻi me ka diabetes mellitus type 2 e kū'ē ana i ke kua o ka hyperglycemia, ke hoʻomalu nei i ka exenatide i ka mea huna nui o ka glucagon. Eia nō naʻe, ʻaʻole e hoʻopili ʻo exenatide i ka pane o ka glucagon maʻamau i ka hypoglycemia.

Kaʻai ʻaʻai: ka hoʻokele o ka exenatide e alakaʻi i kahi hoʻoluhi i ka momona a me ka hoʻohaʻahaʻa ʻana i ka ʻai o ka meaʻai, ke kāohi i ka hoʻomau o ka gastric, e hoʻoiho ana i kona aʻa

Nahuina Gastric: Ua hōʻike ʻia ʻo Exenatide e hoʻoweliweli i ka maʻi palupalu, e hoʻoheheʻe ana i ka ʻōpū o ka gastric. I nā maʻi me ka maʻi diabetes mellitus type 2, hui exenatide i hui pū me ka metformin, thiazolidinedione a me / a i ʻole ka hoʻomākaukau ʻana i ka sulfonylurea hoʻomākaukau i ka emi ʻana o ka ʻai o ke koko glucose, glucose o ka koko postprandial, a me ka HbA 1c, ma laila e hoʻomaikaʻi ai i ka mālama glycemic i kēia mau maʻi.

Kahi papa inoa o nā kūmole

E hoʻokuʻu i ke ʻano (ma o ke kaulana)	Kūʻai, rub.
Baeta
250mcg / ml 2.4ml N1 (Eli Lilly & Company (USA)	11408.20
Baeta Long
0.002 ʻAe mau kaa ʻehā ʻōpio - pono paʻa (AstraZeneca Pharmaceuticals LP (USA)	13829.90
Kokolila * (Exenatide *)

Ua hōʻike i ʻelua mau malihini kipa i kēlā me kēia lā

Ehia mau e lawe ai au iā Byet?
ʻO ka hapanui o nā mea pane i lawe i kēia lāʻau lapaʻau 1 manawa i kēlā me kēia lā. Hōʻike ka hōʻike i ka pinepine o nā mea pane e lawe i kēia lāʻau lapaʻau.

Nā lālā

I ka lā hoʻokahi

He ʻumikumamālua nā malihini kipa i haʻi aku i nā makahiki ahonui

Nā lālā	%
46-60 makahiki	5

41.7%

30-45 mau makahiki

33.3%

> 60 mau makahiki

Nā manaʻo hoihoi

Pehea e koho ai i ka analog kūpono
I loko o ka pharmacology, hoʻokaʻawale pinepine nā lāʻau i nā ʻ synlelo a me nā kikowaena. Hoʻokomo ʻia i ke ʻano o nā like o nā ʻano like ʻole i ke ʻano he hopena therapeutic ma ke kino. Ke hoʻohālikelike nei nā analogs i nā lāʻau lapaʻau e pili ana i nā ʻano like like ʻole, akā no ka mālama ʻana i nā maʻi like.

ʻO nā ʻokoʻa ma waena o nā maʻi a me nā maʻi bacterial
Hoʻopilikia ʻia nā maʻi maʻi e nā maʻi, nā maʻi, nā fungi a me ka protozoa. ʻO ke ʻano o nā maʻi i hoʻomake ʻia e nā maʻi a me nā maʻi like ʻole. Eia nō naʻe, ka hoʻokaʻawale i ke kumu o ka maʻi i ke koho e kūpono i ke ʻano kūpono e kōkua ai i ka hoʻokē ʻana i ka malaise a ʻaʻole ʻoe e hōʻino i ke keiki.

ʻO nā maʻi āpau ke kumu o ke anuanu pinepine
ʻIke kekahi poʻe i kahi kūlana i kahi pinepine ke keiki a a lōʻihi no ka manawa anuanu. Lawe nā mākua iā ia i nā kauka, lawe i nā hoʻokolohua, lawe i nā lāʻau lapaʻau, a ma muli o ke ʻano, ua hoʻopaʻa inoa ʻia ke keiki me ke keiki e like me ka maʻi nui. ʻAʻole i ʻike ʻia nā kumu maoli o nā maʻi ʻeha pinepine.

Urology: hana maʻi urethritis chlamydial
Loaʻa pinepine ʻia Chlamydial urethritis ma ka hana o kahi urologist. Hoʻokumu ʻia e ka intracellular parasite Chlamidia trachomatis, aia nō nā waiwai o nā huakini a me nā maʻi like, ua makemake pinepine i ka antibiotic therapy regimens no ka maʻi antibacterial. Hiki iā ia ke hana i ka mumū ʻole o ka maʻi o ka urethra i nā kāne a me nā wahine.

Nā ʻōkuhi no ka hoʻohana ʻana i ka lāʻau lapaʻau

ʻO ka lāʻau lapaʻau wale nō ka mea e loaʻa ai ka exenatide ʻo Baeta. Ma kahi o ka mea nui, aia kahi liʻiliʻi o nā mea hou: sodium acetate trihydrate, mannitol, metacresol, acetic acid a me ka wai hoʻoneʻe.

Hoʻōla ʻia e nā hui ʻelua ʻelua - ʻo AstraZeneca lāua ʻo Bristol-Myers Squibb Co (BMS). Hoʻokahi wale nō ʻo Baeta i hoʻokahi puka dosage - 250 mg ampoule e loaʻa ana i kahi ala maʻalahi, no kēlā me kēia mea he peni peniʻi kūikawā me ka nui o 1,2 ai ʻole 2.4 ml.

Ke kūʻai ʻia nei ka lāʻau ma ka lāʻau lapaʻau, no laila ʻo ke kauka komo wale nō e hiki ke kuhikuhi i ka mea maʻi. Ma hope o ka loaʻa ʻana o ka mea maʻi i nā ampoules, pono ia e heluhelu pono i nā ʻōkuhi no ka hoʻohana.

Hoʻohana ʻia kēia lāʻau lapaʻau me ka monotherapy a me ka mālama hou aku i nā ʻano maʻi diabetes mellitus type 2, i ka hiki ʻole ke kāohi i ke kiʻekiʻe o ka glycemia. Aia ke aʻo i kahi papa inoa o nā lāʻau lapaʻau i hiki ai iā ʻoe ke hoʻohui i ka lāʻau ʻo Bayeta:

nā biguanides
Ololi Holi,
Thiazolidinedione,
ka hui pū ʻana o thiazolidinedione a me metformin,
ka hui pū ʻana o ka sulfonylurea a me ka metformin.

ʻO ka makeʻana o ka lāʻau lapaʻau he 5 mcg i kēlā me kēia lā 1 ma mua o ka pāʻina nui. Hoʻopiʻi ʻia ma lalo o ka ʻili i ka ʻōpū, ka forearm a me nā ʻūhā paha. Inā kūleʻa ka ʻoihana, ma hope o nā lā 30 e hoʻonui ka nui i ka 10 mcg ʻelua i ka lā hoʻokahi. I ka hihia o ka hoʻohui ʻana i ka lāʻau lapaʻau me nā derivatives sulfonylurea, pono e hoʻemi ʻia ka nui o ka hopena e pale ai i ka hōʻemi wikiwiki i ka pae gula. I ka wā o ka hoʻolahaʻana o ka hoʻonā, pono e mālama ʻia nā lula iā ia:

ʻaʻole ke alakaʻi ʻia ka lāʻau lapaʻau ma hope o ka ʻaina,
mai hoʻonoho i intravenously a i ʻole intramuscularly,
inā ua hoʻololi ka hoʻonā a i loaʻa nā hapa, ʻaʻole pono ia e hoʻohana;
i ka wā o ka mālama ʻana, hiki i ka hoʻouluʻana o ka antibody.

ʻO ka lāʻau lapaʻau e mālama i kahi wahi pōʻeleʻele i nā keiki liʻiliʻi ma kahi wela o 2-8C.

ʻO 2 mau makahiki ka ola o ka noho, a ʻo ka hoʻonā i loko o ka syringe peni he 30 mau lā ma kahi pākeke ʻoi aku 25 mau māka.

Nā hiʻohiʻona a me nā hopena maikaʻiʻole

E like me nā lāʻau ʻē aʻe, ʻo ka lāʻau lapaʻau Bayeta kekahi mau contraindications:

maʻi diabetes type 1
ketoacidosis (nā maʻi i ka metabolism,)
pilikia hōʻeha (ʻoi aku ka waiwai o CC ma mua o 30 ml / min),
ka pilikino pilikino i nā ʻāpana o ka lāʻau lapaʻau,
hoʻoweliweli kaʻe ʻana o ka ʻōnaehana ʻole me ka huhū,
hāpai a ʻeha
na keiki a me na opio malalo o na makahiki 18 aku.

No kekahi kumu, e laʻa me ka hoʻohana ʻole ʻana i ka lāʻau, hiki i nā hopena ʻaoʻao.

kūwaho kūloko - urticaria, rashes ma ka ʻili, kaʻili.
ka hana ʻana o ka hana kūwele - ka hoʻomehana a me ka luaʻi, nui ka lemela, constipation a ʻole i ka maʻi ʻaʻa, hoʻemi ʻia ka makemake momona a me ka paona.
nā hana ʻole o ka ʻōnaehana o ka puna ma waena - nā huhū, nā ʻeha, nā ʻeha me nā maʻi o ka maʻi a me nā ʻeha;
puʻuwai a palau paha,
hoʻoulu serum,
mokuahi hypoglycemic, hyperhidrosis, pancreatitis.

I kēlā mau kūlana, pono ke kamaʻilio e nīnau me ke kauka e hoʻoponopono i ka regimen lapaʻau.

Pono ʻoe e hōʻemi i ka dosage a i ʻole hoʻokū i ka lawe ʻana i kēia lāʻau lapaʻau.

ʻO ke kumukūʻai, nā loiloi a me nā analogues o ka lāʻau lapaʻau

Hiki ke kūʻai ʻia ka lāʻau Baeta ma kahi lāʻau kūʻai a waiho paha i kahi kauoha ma ka Pūnaewele. ʻO ka mea no ke kau ʻia ka lāʻau lapaʻau, ʻo ke kumukūʻai no ia, e like me ia, kiʻekiʻe loa. No laila, ʻaʻole hiki i nā mea āpau ke kūʻai aku.

Kūlike ke kumukūʻai e pili ana i ka nui o ka hoʻonā, ke kumukūʻai o ka halihali a me ka palena o ka mea kūʻai:

1,2 ml syringe pen - mai 4246 a 6398 Russian mau rubles,
2.4 ml syringe pen - mai 5301 a 8430 mau rubles Lūkini.

Nui nā poʻe maʻi i loaʻa i ka hoʻonā ʻana o Bayet i kēia me kēia lāʻau lapaʻau. ʻO ka mea mua, hoʻohana ʻia i hoʻokahi wale nō i ka lā, a me ka lua, hoʻohaʻahaʻa loa ia i ka pae o ka glucose a me ke kaumaha o ke kino i kahi kanaka luhi.

Eia naʻe, ma hope o ka hoʻokuʻu o ka lāʻau lapaʻau, hana nā mea hana i kahi noiʻi kūʻai mahele i lawe ai i nā maʻi maʻi manuahi. Ua hōʻike ʻia nā hopena o ka hōʻike ʻana i ka hapa nui o nā poʻe e lawe nei i ka lāʻau lapaʻau i kēia mau hopena maikaʻi ʻole.

Flatulence, constipation, i nā hihia i loaʻa - maʻi pancreatitis.
Urticaria, pruritus, alopecia (lauoho lauoho), angioedema, maculopapular rash.
ʻO ka lepo ma muli o ka luaʻi, makemake ʻole e lilo ka kaumaha.
ʻO ka palupalu, nā nele a ʻole ka lula ʻana o ka hoʻāʻo.
Impaired 'ōpole hana, hoʻokiʻekiʻe ke kiʻekiʻe, pale ʻole a i ʻole kona hoʻohui.
ʻO ka hōʻike manaʻo anaphylactic.

E like me nā analogue e hoʻopili ana i ka waiwai like, ʻaʻohe mau. Ma kahi mākeke lāʻau Lūkini, hiki iā ʻoe ke loaʻa nā lāʻau lapaʻau i loaʻa ka hopena therapeutic like. Hoʻopili kēia me ka mimetin mimetin - Viktoza a me Januvius. Hiki i nā ʻike kikoʻī hou aku e pili ana iā lākou ma ka Pūnaewele a nīnau aku i kāu kauka.

A no laila, exenatide, aia i loko o ka hoʻomākaukau ʻana o Bayeta, e hoʻohaʻahaʻa me ka pae o ka glucose i loko o ke koko a ʻaʻole alakaʻi i ka hypoglycemia. Kūkū ke kauka i kēia lāʻau lapaʻau, e kāpae i nā contraindications hiki, ke kūlohelohe a me ka noʻonoʻo ʻana i nā ʻano kūʻokoʻa o ka mea maʻi. Ke hoʻohana nei i ka lāʻau lapaʻau, hiki iā ʻoe ke pale i nā hōʻailona o ka maʻi diabetes ma ke ʻano lōʻihi. E ola kino!

No ka loaʻa ʻana o ka uku mau ʻia, pono e loaʻa i ka mālama ʻana no ka maʻi type 2. Pehea e mālama ai i kahi maʻi e haʻi i ka mea loea i ka wikiō ma kēia ʻatikala.

Baeta | ʻO nā mea hoʻohālike Lūkini a me nā kumukūʻai a me nā loiloi

| | |. ʻO nā mea hoʻohālike Lūkini a me nā kumukūʻai a me nā loiloi

ʻO kahi maʻi ʻo mellitus ka maʻi maʻi e hoʻololi nui i ke ola o kahi kanaka. Ma muli o ia mea, pono ʻoe e hahai i ka meaʻai paʻa a me ka hoʻomaʻamaʻa, akā e tupu ana ʻaʻole lawa kēia. I kēlā mau kūlana, aia ka pono no ke kōkua olakino. ʻO Baeta kahi lāʻau lapaʻau i hoʻolālā ʻia e hōʻoluʻolu i nā kiʻekiʻe o ka glucose koko.

Ke noi

Baeta - kahi lāʻau lapaʻau e hana ana i ka hopena hypoglycemic. Loaʻa ia ia ka mea kaha exenatide, kahi syntical. Me ia, he ka emi iki o ka pae o ka glucose i ka ʻōnaehana ka neʻe ʻana.

Paipai ʻo Baeta i ka hana ʻana i ka hana ʻo GLP-1 (loaʻa kēia me ka mea waiwai exenatide, ʻo ia kekahi o ka mimetin mimetic). ʻ allowslelo i ka lāʻau lapaʻau nā poli pancreatic beta e hoʻomaʻamaʻa i ka hana o ka insulin.

Inā hōʻeha ka mea maʻi i ka hyperglycemia, a laila hoʻoneʻe ʻo Byeta i ka mea huna o glucagon. He mea nui ia e hōʻike ka lāʻau lapaʻau i ka pane o ka glucagon. Hoʻololi ka Byeta i ka nui o ka hoʻonuiʻana i nā waihona mai ka papa gastric.

Hoʻemi kēia i ka momona a me ke kaumaha o ka mea maʻi.

Hiki i ka lāʻau lapaʻau ke hoʻohana no ka hui pū me ka metformin a me ka insulin. Me ke kōkua o kēia, ua hōʻemi ʻia ka nui o ke kō koko koko i nā mea maʻi a hiki ke loaʻa i kahi pae maʻamau o ka mana no ka glycemic.

Ke hōʻike nei nā ʻōkuhi i nā hōʻike hōʻike e pili ana i ka hoʻohana ʻana i ka lāʻau lapaʻau no ka maʻi diabetes mellitus type 2.

No ka monotherapy, i hoʻohana ʻia me ka hoʻopiha ʻana i nā hana kino a me ka mālama ʻana i nā meaʻai.
No ka hui pūʻana me nā lāʻau lapaʻau me kahi algorithm like o ka hana, ka insulin a me ka metformin. Hoʻohana ʻia inā ʻaʻole lawe mai nā monotherapy i nā hopena kūpono.

Hoʻokomo ʻia ka lāʻau lapaʻau i loko o ka ʻili, ma hope o ka lilo ʻana o ka mea ikaika e hoʻopili koke ʻia. Loaʻa ka hopena loa o ka lāʻau i ʻelua mau hola ma hope o ka hoʻokele ʻana.

Hoʻopili wale ʻia ka mea hana ikaika e nā keiki. ʻO ka hoʻopau hope loa o ka hapalua-ola he 2 mau hola.

Kaumaka, gender, a me nā makahiki (me nā hana o ke keiki ma kahi pae kūpono) ʻaʻohe hopena o ka hoʻohana ʻana i ka lāʻau.

ʻO nā haʻawina e hiki ai ke hoʻomaopopo i ka pōʻino o ka lāʻau i ka wā hāpai a me ka lactation ʻaʻole i hana. I loko o kēia manawa, hoʻohana pinepine 'ia ka insulin a me Baeta analog.

ʻAʻole i mālama ʻia nā noi ʻana o ka hoʻohana ʻana i ka lāʻau i nā keiki ma lalo o 18 makahiki. I kēlā mau kūlana, ua hoʻohana ʻia ka insulin a me nā lāʻau ʻē aʻe me kahi algorithm like o ka hana.

Nā hopena hopena

E noʻonoʻo i nā hopena pili i hiki ke hele mai i ka wā e hoʻohana ai i ka lāʻau lapaʻau:

ʻŌpala Gastrointestinal. Hoʻopilikia i nā mea ʻono, nā pilikia me nā kīwaha, aihua, ke kuʻe ʻana i ka ʻōpū, ka puʻu kiʻekiʻe i loko o nā ʻōpū, pancreatitis.
Hāpai. Inā ʻoe e hoʻohana i ka lāʻau lapaʻau ma ke ʻano o ka hui ʻana me ka insulin a i ka metformin, a laila hiki mai ka hypoglycemia.
Pūnaehana pīhoihoi waena. Ke lō nei i nā manamana lima, manaʻo i ka nawaliwali a hoʻonui pākuʻi.
Allhesic rashes ma ka pūnaewele injection. Hoʻopili i nā palahalaha a me ka nui.
ʻO Renal hiki ʻole.

Inā ʻoe e hoʻohana i ka lāʻau lapaʻau no ka manawa lōʻihi, a laila hiki i ke ʻano o nā antibodies i hiki. ʻOi aku kēia hana i ka hana hou. Pono e haʻalele i ka lāʻau lapaʻau, pani iā ia me kahi mea like ʻole, e hele aku nā antibodies.

ʻAʻohe he antidotes ka Baeta. Hoʻokomo ka hopena no ka hopena ʻaoʻao i nā hōʻailona.

Aia ke kumukūʻai ma ke kumu kīnā:

No ka hoʻolālā o 1.2 ml e uku ai ʻo 3990 mau rubles.
No ka hopena o ka 2,4 ml - 7890 rubles.

I loko o nā lāʻau lapaʻau ʻē aʻe, e piʻi ke kumukūʻai. No laila, no ka laʻana, ua loaʻa kahi hopena o 1.2 ml no ka 5590 rubles, a me 2.4 ml - 8570 rubles.

E noʻonoʻo i nā mea like o Bayeta:

Avandamet. Loaʻa he mau mea laikini metformin a me rosiglitazone, e hoʻohui pū kekahi. Hāʻawi ka lāʻau lapaʻau i ka mālama ʻana i ke kiʻekiʻe o ka glucose i ka ʻōnaehana kao, hoʻonui i ka ʻike ʻana i nā peka beta pancreatic i ka insulin. Hiki ke kūʻai no ka 2400 rubles.
Arfazetin. Loaʻa i kahi hopena hypoglycemic. Kōkua i ka hoʻemi ʻana i ka glucose i loko o ka ʻōnaehana kaila. Hiki ke hoʻohana ʻia no ke kākoʻo kākoʻo, akā ʻaʻole kūpono ia no ka mālama pono. Hoʻomaʻamaʻa ka lāʻau lapaʻau ʻaʻohe hopena hopena a ua ʻoi aku i nā mea hou aʻe i nā analog kekahi i ke kumukūʻai. Kūlā - 81 mau rubles.
Bagometua. Hiki i nā mea waiwai glibenclamide a me metformin.Hoʻonui nā mahele o ka maʻi i ka insulin. Hoʻēmi i ka kolamu. Kōkua ka lāʻau lapaʻau i ka mea huna o ka insulin. Hiki ke kūʻai ʻia no 332 mau rubles.
Betanase I ka hoʻomaʻamaʻa ʻia me kēia mākaʻi, mālama pono ka mālama ʻana i ke kūlana o ke koko. Hoʻokomo ʻia ka lāʻau lapaʻau ma ka wā hāpai a me ka lactation. ʻAʻole ʻae ʻia ia e inu i ka waiʻona a me nā lāʻau lapaʻau e loaʻa ana ka ethanol i ka wā mālama. ʻAʻole paʻakikī e loaʻa i loko o nā lāʻau kūʻai.
Victoza. ʻO ka lāʻau lapaʻau maikaʻi loa a koʻikoʻi. Hoʻopili i nā mea ikaika liraglutide. Hoʻonui ka pilikia i ka huna ʻana i ka insulin, akā ʻaʻole ka glucagon. Hoʻemi ka Liraglutide i ka makemake o ka mea maʻi. Kūʻai ʻia ma ke ʻano o nā syringe. Kumukūʻai - 9500 rub.
ʻO Glibenclamide. Aia i ka glibenclamide mea hana ikaika. Hoʻonui i ka hopena o ka insulin ma ka huki ʻana o ka honi ma waena o ka pūnaehana mākala. Loaʻa i ka lāʻau lapaʻau ka hopena haʻahaʻa o ka hoʻomohalaʻana i ka hypoglycemia. Hiki ke hoʻohanaʻia e like me ka māhele o ka hui hui. Kia kani no nā rubles 103.
ʻO Glibomet. Nā hānona metformin. Hoʻopau i nā mea huna o ka insulin. Hiki iā ia ke hoʻopau me ka insulin. Hoʻonui ka lāʻau lapaʻau i ka pilina o nā insulin me nā mea pane, ʻaʻohe hopena o ka hoʻomohala ʻana i ka hypoglycemia. Kumukūʻai - 352 rub.
Gliclazide. ʻO ka mea waiwai e gliclazide. Hāʻawi iā ʻoe e hoʻohālikelike i ka pae o ke kō i loko o ke kaikuawai. Hoʻemi i ka hopena o ka vomb thrombosis, kahi maikaʻi no ke olakino. Kumukana - 150 rubles.
Metformin. Hoʻokomo i ka gluconeogenesis. ʻAʻole hoihoi ka lāʻau lapaʻau i ka mea huna o ka insulin, akā hoʻololi i kona kūloko. E ʻae i nā pūlehu o nā mākala e hoʻomaʻamaʻa i nā glucose. Kumukana - 231 rub.
Hoavius. Loi sitagliptin. Hoʻohana ʻia no ka monotherapy a i ʻole ka hoʻohui ʻana i ka mālama ʻana. Hoʻonui i ka synthesis insulin, me ka hoʻonaninani ʻana i nā ʻāpana pancreatic iā ia. Kumukana - 1594 rubles.

He aha ke ala kūpono e hoʻopili ai mai kēia mau metekema āpau? Aia ia i ka helu ʻana o ka mea maʻi. ʻAʻole ʻae ʻia ia e hoʻololi i kekahi lāʻau i kekahi mea ʻē aʻe ma mua o kou iho, ma mua o ka hoʻohana ʻia he pono ke nīnau aku i kahi loea.

E noʻonoʻo i nā loiloi e waiho ai nā kānaka e pili ana i ka lāʻau lapaʻau Bayeta:

Ua kākau ʻo Galina (//med-otzyv.ru/lekarstva/144-b/35082-baeta#scomments) ʻaʻole pono kēlā mau laʻa ke kulana. Ua hoʻololi wale ka wahine i ka lāʻau lapaʻau, ma hope o ka hoʻihoʻi ʻana o kona ʻano maʻamau. Ua kākau ʻo ia ka mea nui e mālama i ka meaʻai.

Wahi a Dmitry (// med-otzyv.ru/lekarstva/144-b/35082-baeta#scomments) ua hoʻohana ʻo ia i ka lāʻau lapaʻau no hoʻokahi makahiki. Mālama ʻia ka Sugale i kahi papa maikaʻi, akā ʻo ka mea nui, e like me ke kāne, he emi ka nui o ke kino ma ka 28 kg. ʻO nā hopena maikaʻi, hopena ia i ka nausea. Wahi a Dmitry, he lāʻau lapaʻau maikaʻi kēia.

ʻStlelo aku ʻo Konstantin (//med-otzyv.ru/lekarstva/144-b/35082-baeta#scomments) he maikaʻi ka lāʻau lapaʻau, akā naʻe, ʻae ʻia ka ʻae ʻana. Manaʻoʻo ia hiki iā ia ke loaʻa i ka analogue o ka lāʻau lapaʻau, ke loaʻa nei i nā ʻano papa papa.

Hōʻike nā hōʻike ʻaʻole i kōkua ka lāʻau lapaʻau i nā mea āpau. ʻO kekahi o kona pilikia nui ke ʻano o ka hoʻokuʻu ʻana. ʻAʻole kūpono kēia no nā maʻi āpau.

Baeta - kahi lāʻau lapaʻau e hiki ai iā ʻoe ke hoʻonohonoho pono i ke kiʻekiʻe o ka hilo i loko o ka ʻōnaehana kao. He mea kūpono loa ia, akā ma kekahi mau mea i kuhikuhi ʻia no ka manuahi ma nā haukapila. Inā hoʻolohe ʻoe i nā loiloi hoʻomanawanui, ua lōʻihi loa ka lāʻau lapaʻau mai ka lehulehu.

Mālama a hoʻohele paha:

E pili ana i ka lāʻau lapaʻau

ʻO ka lāʻau ʻo Baeta e hana ʻia e kahi ʻoihana kaulana ma UK. ʻO nā huaʻai i nā antagonist o ka peptide e like me ka pona o ka glucagon, he mea hoʻohālike i ka pakano. ʻO ka hopena laila i ka lāʻau lapaʻau ma muli o ka hoʻonui ʻana o nā hana beta, me ke ʻano he pane no ka meaʻai ʻaina a me ka kō i loko o ke kino. Ma hope o ka ʻai ʻana, hoʻopaʻa ʻia ʻo Baeta i ka huli ʻana o ka glucagon a hoʻokuʻu ʻia i ka periphery.

ʻO nā mea hana e kū nei i loko o ka pūnaehana o ka lāʻau lapaʻau e hana ai i ka mea hoʻomohala ma kahi ʻano hoʻohui.

me ka hyperglycemia, hoʻohaʻahaʻa lākou i ke kahe o ke kō i loko o ke koko,
hoʻoulu i ka pancreas,
huna i kahi hapanui e like me ka insulin,
hoʻemi i ke kaumaha o ke kino
hoʻohaʻahaʻa i ka makemake o ka mea maʻi,
nanea, i ka manawa e loaʻa ai i nā ʻōmaʻomaʻo i kūlohelohe - hoʻopau ʻia kona hopena,
hoʻokomo ʻia i loko o ke kino o ka mea maʻi e ka subcutaneous injection,
ʻae ʻia no ka hoʻohana ʻia e nā kānaka me 1 ʻano maʻi.
Ua manaʻo ʻia he mea kūpono a hoʻokau like o ka insulin (ʻokoʻa ia mai ka hormone ma kona ʻano synthet a me ka hana kemika).

Hoʻohana ʻia ka lāʻau lapaʻau e like me ka monotherapy, a me ka neʻe pū ʻana me nā lāʻau lapaʻaka hypoglycemic o ka hopena kūloko. ʻO ka insulin synthetic hoʻokuʻu i pale i ka glucose, e pale i kona hōʻiliʻili ʻana i nā kīʻaha koko, nā ʻāpana a me nā kiko. ʻO ka lāʻau lapaʻau no ka mālamaʻana i ka maʻi diabetes ua kaulana loa i waena o nā poʻe maʻi no nā kumu he nui.

ʻO ka hopena therapeutic e pili ana i ka hoʻokele subcutaneous o ka lāʻau lapaʻau, ʻoiai ke loaʻa ka hoʻopau ʻana o nā mea ikaika, a ma hope o nā hola ʻelua ke hoʻi mai ka pae o ke kō i ka maʻamau. Hoʻonui ʻia ka hopena a kū ma ka lā hoʻokahi. Hoʻokuʻu ʻia ia mai ke kino me ka urine me ka ʻole e hoʻololi i nā ʻano physicochemical o ka urine.

E hoʻokuʻu i ke ʻano a me ka ʻano

ʻO ke ʻano dosage o ke kinikini antidiabetic he penina syringe me kahi pahu kaʻa i kū ʻole ʻia. E nānā i ke ala o ka hanauna hou. Hoʻohana ʻia e lawelawe e lawelawe ai i ka hormone ascetin subcutaneously (ʻaʻole i hoʻokomo ʻia nā pono jareka). ʻAʻohe o ka hoʻonā Baeta no ka ʻulaʻula ʻole.

ʻO ka mea hana o ka lāʻau lapaʻau ka Exenatide ma kahi paʻa o 250 mg. Hoʻokaʻawale ʻia kēia ʻano mai ka lawaiʻa o kahi kīnā, ka ʻano kūʻokoʻa e waiho nui ʻia ana i ka wai ʻole o ka pono o ka pono.

I ka wā o kahi pōloli ʻolua, koi nui ka pancreas o ka reptile i ka insulin. Hoʻokumu i kēia hanana, ua hoʻokumu ʻia ka hopena o ka exenatide ma ka maʻi diabetes.

Ma kahi o nā mea ikaika, aia nā mea kōkua i loko o ka hoʻopili ʻana o ka lāʻau lapaʻau.

ʻO ke kō o ke koko mau ka 3.8 mmol / L

Pehea e mālama ai i ke kō i ka maʻamau ma 2019

ka huehiko o ka huehue (glacial),
mannitol
wai
sodium trihydrate ma ke ʻano o ka acetate,
metacresol

Hoʻonui ka paʻakikī o nā mea hoʻopihapiha a me ka mea hoʻoikaika i ka hopena o ka lāʻau lapaʻau, e ʻae ana i ka poʻe maʻi maʻi e alakaʻi i kahi ʻano maʻamau.

Nā ʻōlelo kikoʻī

Pono ka lāʻau e mālama ai i ka maʻi maʻi type 2. ʻAʻole ia e ʻae ʻia e hoʻohana ʻo Byet i nā maʻi me ka maʻi diabetes mellitus type 1, me ke ʻano pū ka maʻi a piʻi paha ka piʻi ʻana o ka hormone pancreatic.

ʻAʻole pili ʻo Byeta i ka wili i loko o ka insulin. Hoʻohana ʻia ia i nā maʻi hakahaka ma ka haʻalele ʻole o kahi hopena therapeutic aʻo ke hoʻohana ʻana i ka Metformin. ʻAʻole ke ʻano lāʻau lapaʻau i ka wā e hoʻololi ana mai kekahi ʻano o ka insulin i kekahi.

No ka mālama ponoʻana i ka maʻi maʻi ma ka home, ʻōlelo ke akamai o nā loea HeLoha. ^ E Ha yM. He mea kupanaha kēia:

Hoʻolālā i nā glucose koko
Kāohi i ka hana pancreatic
Hoʻokuʻu i ka puffiness, hoʻoponopono i ka metabolism wai
Hoʻomaikaʻi i ka ʻike
He kūpono no nā pākeke a me nā keiki.
ʻAʻohe contraindications

Ua loaʻa i nā mea hana nā laikini pono e pono ai a me nā palapala hōʻoia ma Rusia a ma nā ʻāina e kokoke ana.

Hāʻawi mākou i kahi haʻawina i ka poʻe heluhelu o kā mākou pūnaewele!

Kūʻai ma ka pūnaewele mana

Hoʻomaopopo ka poʻe maʻi i ka hiki o ka pohō kaumaha no ka emi ʻana o ka makemake. Hoʻopau ʻia ka ʻike ʻana i nā palena o ke koko i kēlā me kēia lā, no ka mea ʻaʻole ia e hala i ka emi ʻana o ke kaʻe o ka glucose i lalo o nā waiwai ʻoluʻolu.

He mea koʻikoʻi ia i ka wā eʻai ai me Exenatide a mālama i kahi ʻano hana.

E hui pū me nā lāʻau lapaʻau ʻē aʻe

Ma kahi ʻāpana o nā lāʻau paʻakikī, ua hoʻokaʻawale ʻia nā lāʻau hoʻohaʻahaʻa i ke kō me ka mālama ʻana, no ka mea, e pili ana i nā lāʻau lapaʻau o nā ʻano lāʻau lapaʻau ʻē aʻe.

me nā lāʻau antihypertensive (Lisinopril), ka waena ma waena o ka lawe ʻana i nā papa a me ka hoʻokele o Bayet e pono e mālama ʻia,
ka ʻoihana me ka warfarin e hoʻonui i ka manawa o ka hoʻopau ʻana o nā mea hypoglycemic,
i ka wā e hoʻohana ai i ka cholesterol-hoʻemi ʻana i ka lāʻau Lovastatin, nāwaliwali ka hopena o ka exenatide,
Hoʻonui ka waha hypoglycemic waha i ka hopena o ka exenatide, kahi mea e koi ai i ka emi o ke kō o ke koko,
me ka digoxin sedative glycoside, ke emi nei ka hopena o nā mea āpau a e hoʻonui ka manawa.

ʻO nā papa kiʻi ʻoniʻoni a me nā kapoti, ʻo ka hoʻopiʻi ʻia ʻana o ka mea e loaʻa mai ana i ka ʻoki ʻoihana gastrointestinal, pono e lawe ʻia ma mua o ka lawelawe ʻana o subcutaneous o Baeta. Ke hoʻomau nei i ka maʻi dyspeptic e pili pono i ka pharmacodynamics o nā lāʻau lapaʻau a me ke kūlana o ka gastrointestinal tract.

Baeta: nā ʻōkuhi no ka hoʻohana, nā kumu kūʻai, nā loiloi, nā analogues

Hoʻopau koʻikoʻi: loaʻa exenatide 250 mcg.

Nā mea kūʻai: sodium acetate trihydrate, glacial acetic acid, mannitol, metacresol, wai i / i.

Nā ʻōkoʻomanaʻo Bayeta

Monotherapy: Type 2 diabetes mellitus as monotherapy i ka hoʻohui i ka meaʻai a me ka hana e hoʻokō ai i ka mana glycemic kūpono.

ʻO ka maʻi diabetes mellitus type 2 he hana hoʻomohala hou i ka loaʻa ʻole o ka mana glycemic kūpono i:

Metformin, kahi derivative sulfonylurea, thiazolidinedione.
ʻO ka hui pū ʻana o ka metformin a me kahi derphative sulfonylurea.
Metformin a me thiazoldinedione.

Nā Palapala Kūmole

ʻO ke ʻano maʻi mellitus type 1 a i ʻole ka hele ʻana o ka ketoacidosis maʻi. Hōʻea kino hōʻino (ʻo ka cleinine clearance ma mua o 30 ml / min). ʻO ka heleʻana o nā maʻi gastrointestinal nui me ka gastroparesis concomitant. Kahawai

Lactation (hoʻomaʻamaʻa). ʻO nā keiki ma lalo o ka 18 mau makahiki o ka palekana (palekana a me ka pono o ka lāʻau lapaʻau i hoʻopaʻa ʻia ʻole).

ʻO ka hypersensitivity e exenatide a i nā mea i hoʻopiʻi ʻia i hoʻomālamalama ʻia i ka lāʻau lapaʻau.

Nā manaʻo e hoʻohana

Hoʻohana ʻia ka lāʻau lapaʻau sc i ka ʻūhā, ka ʻōpū a i ʻole ka lima. ʻO ka dosis mua he 5 mcg, ka mea i mālama ʻia i nā manawa 2 i kēlā me kēia manawa i kahi manawa no 60-mau minuke ma mua o ke kakahiaka a me ke ahiahi ʻaina. Mai alakaʻi i ka lāʻau lapaʻau ma hope o ka ʻaʻa ʻana.

Inā pau ka loaʻa ʻana o ka lāʻau lapaʻau, hoʻomau ka mālama ʻana me ke hoʻololi ʻana i ka nui. 1 mahina ma hope o ka hoʻomaka ʻana o ka mālama ʻana, hiki ke hoʻonui ʻia ka nui o ka lāʻau i ka 10 mcg i nā manawa 2 i ka lā.

Ke hui pū nei me ka metformin, thiazolidinedione, a i ʻole me ka hoʻohui ʻana i kēia mau lāʻau, ʻaʻole hiki ke loli i ka hopena mua o ka metformin a me / a thiazolidinedione wale nō.

I ka hihia o ka hui pū ʻana o Bayeta ® me ka derivatives sulfonylurea, pono e hoʻemi ʻia ka nui o ka derivative o ka sulfonylurea e hōʻemi i ka hopena o ka hypoglycemia. Hoʻohana no ka hana renal impaired

Hoʻokomo ʻia ka lāʻau lapaʻau i ka hana ʻole o ka pilikia (ʻo ka hana loea ma lalo o 30 ml / min).

ʻO nā hopena ʻaoʻao o Baeta

ʻO ka hopena ʻino e loaʻa pinepine ai i nā hihia kaawale i kahi i hoʻohālikelike ʻia me ka hoʻokiʻina ʻana aʻe: pinepine - ≥10%, pinepine - ≥1%

Mai ka papa hana ʻana: pinepine pinepine - kaila, ka luaʻi, ka maʻi ʻaʻa, pinepine - ka nalo ʻana o ka ʻono, dyspepsia, gastroesophageal reflux, i kekahi manawa - ʻeha o ka ʻōpū, ka ʻūhū, ka ʻōpū, ka constipation, ka hōʻino o ka ʻono o ka ʻono, flatulence.

Mai ka ʻaoʻao o ka pūnaehana loko ma waena: pinepine - dizziness, headache, jarang - hiamoe.

Mai ka ʻōnaehana endocrine: pinepine loa - hypoglycemia (i hui pū me ka derogatives sulfonylurea), pinepine - ke ʻano o ka haʻalulu, nāwaliwali, nā hyperhidrosis.

He maʻi kūloko: ʻaʻole - palupalu, kauhā, angioedema, loaʻa pinepine loa ka hopena - anaphylactic.

Nā mea ʻē aʻe: pinepine - he ʻano ʻili i ke kahua hōʻeha, līkuhi - make ka pilina (pili me ka ninini, ka luaʻi a me / a me nā maʻi ʻana). Ua hōʻike ʻia kekahi mau hihia o ka nui o ka manawa koikoi koko (INR) me ka hoʻohana pinepine ʻana o nā warfarin me ka exenatide, kahi mea hui pū ʻia me ke koko.

Ma muli o ke hoʻonui ʻana i ka nui o ka hypoglycemia me ka hoʻopili pū ʻana me ka lāʻau Baeta me nā derivatives o sulfonylurea, pono pono e noʻonoʻo i ka hoʻēmi ʻana o ka paʻakai o ka papa o nā aogonylurea me ka hoʻonui nui aʻe o ka hypoglycemia. ʻO ka hapa nui o nā hypoglycemia i ka uluʻana he mau haʻahaʻa a maʻalahi i hoʻopaʻa ʻia a pale ʻia e ka waha o ka calcium acidate.

Ma ka laulā, ka hopena o ka ʻaoʻao a i ʻole me ka hoʻohaʻahaʻa i ka ikaika a ʻaʻole i alakaʻi i ka haʻalele ʻana o ka hana. ʻO ka pinepine, hoʻopaʻa inoa iki i ke ʻano hōʻoluʻolu ʻoluʻolu a me ke ʻano hoʻohaʻahaʻa i ka palena a hoʻēmi ʻia i ka manawa, me ka hoʻēmi ʻole ʻole i ka hana o kēlā me kēia lā.

ʻAʻole ia i kāpae ʻia i loko / a i ʻole i ka mana m / i ka lāʻau lapaʻau.

ʻAʻole pono ke hoʻohana ʻo Bayeta® inā ʻike ʻia nā palulu i kahi hopena a inā he pohā paha ka hopena a i ʻole kahi manawaleʻa.

E ʻike paha nā anavodies e exenatide i ka wā maʻi me ka Bayeta®. Eia naʻe, ʻaʻole ia i pili i ka pinepine a me nā ʻano o nā hopena hōʻike i hōʻike ʻia.

Pono e hoʻomaopopo ʻia nā mea maʻi e hiki ke mālama ʻia me ka Bayeta® i ka hoʻemi ʻana i ka momona a me / a i ke kaumaha kino paha a ma muli o kēia mau hopena, ʻaʻohe mea e pono ke hoʻololi i ka noho hoʻoponopono ʻia.

ʻO nā mea maʻi ma mua o ka hoʻomaka ʻana i ka mālama ʻana me ka Bayeta® pono e hoʻomaʻamaʻa iā lākou iho me ke alakaʻi ʻana i ka hoʻohana ʻana i kahi penehina ʻili i pili ʻia i ka lāʻau lapaʻau.

Nā hopena o nā noi hoʻokolohua

Ma nā noi preclinical i loko o nā mehe a me nā kahe, ʻaʻole i ʻike ʻia ka hopena carcinogenic o exenatide. I ka manawa i hāʻawi ʻia ai nā kiʻī he 128 manawa mau manawa i loko o nā kānaka, he helu helu i loko o C-cell thyroid adenomas i ʻike ʻia me nā hōʻailona ʻole o ka malignancy, ka mea i hui pū ʻia me ka hoʻonui ʻana i nā ola o nā holoholona hoʻokolohua e loaʻa i ka exenatide.

Nā hōʻailona: ka maʻi ʻeha a me ka luaʻi, a me ka wikiwiki ka hoʻomohala ʻana o ka hypoglycemia (i ka wā e lawe ai i kahi momona 10 mau manawa kiʻekiʻe ma mua o ka mea i hōʻike ʻia aʻe).

Hoʻomaʻamaʻa: lawe ʻia ka hana hōʻailona hōʻailona, me ka hoʻokaʻawale ʻana o nā kūpuna o ka glucose i ka hihia o ka hypoglycemia koʻikoʻi.

Pono e hoʻohana ʻia ʻo Bayeta® me ka akahele i ka poʻe maʻi e lawe ana i nā lāʻau lapaʻau e pono ai ke komo koke ʻana mai ka ʻeha o ka gastrointestinal, no ka mea Hiki ke hoʻolōʻihi i ka Byeta® i ka pani ʻana i ka ʻōpū.

Pono e ʻōlelo ʻia nā mea maʻi e lawe i ka lāʻau lapaʻau waha, ka hopena o ka mea e hilinaʻi ana i ka paepae ʻana o ka paepae (e.

Inā pono e lawe ʻia nā mea inu like me ka meaʻai, a laila e lawe ʻia i ka wā o ia mau meaʻai i ka wā ʻaʻole i hoʻokele ʻia nā exenatide.

Me ka hoʻokolohua mau ʻana o ka digoxin (ma kahi o ka 0.25 mg 1 manawa / lā) me ka mākaukau ʻo Bayeta®, ka palena o ka digoxin e hōʻemi ana i ka 17%, a hoʻonui ka nui o T max i nā hola he 2, akā naʻe, ʻaʻole e loli ka hopena o ka pharmacokinetic ma ke kāʻualua.

Me ka hoʻomaka ʻana o Bayeta®, hōʻemi ʻia ʻo AUC a me Cmax o lovastatin e ka 40 a me 28%, kēlā me kēia, a me ka Tmax i hoʻonui ʻia ma kahi o nā hola he 4. ʻO ka hoʻokele ʻana o Bayeta® me nā HMG-CoA reductase inhibitors ʻaʻole i mālama ʻia e nā loli e ka hui lipid wai (HDL cholesterol,. LDL kolamu, ka nui o nā kolamu a me nā triglycerides).

I nā mea maʻi me ka hypertension arertial maʻalahi a maʻalahi i hōʻoli ʻia e ka lisinopril (5-20 mg / lā), ʻaʻole i loli ʻo Bayeta® i ka AUC a me Cmax o ka lisinopril ma ka equilibrium. ʻO ka Tmax o ka lisinopril ma ka equilibrium i hoʻonui ʻia e nā hola 2. ʻAʻole i hoʻololi i nā hōʻailona o nā awelika o kēlā me kēia lā ʻo SBP a me DBP.

Ua hōʻike ʻia me ka hoʻomaka ʻana o warfarin 30 mau minuke ma hope o ka mākaukau ʻana o Bayeta® Tmax i hoʻonui ʻia ma kahi o nā hola 2. ʻAʻole i ʻike ʻia kahi loli koʻikoʻi ma Cmax a me AUC. ʻO ka hoʻohana ʻana o Bayeta® i hui pū me ka insulin, e pili ʻole i ka derivatives D-phenylalanine, meglitinides a i loaʻa ʻole alpha-glucosidase inhibitors.

E mālama ma kahi mahana o 2 a 8 ° C. Noho ola: 2 mau makahiki.

Nā kumumanaʻo i ka mea haku mele a me nā hōʻike no ka hoʻohana

Ke poʻo inoa	He kumukūʻai ma Rusia	Kumukūʻai ma Ukraine
Baeta Long Exenatide	10248 ʻōpala	--

ʻO ka papa inoa ma luna o nā mea hoʻohālikelike lapaʻau, e hōʻike ana Ua koho ʻo Baeta, kūpono loa ia no ka mea ua like lākou me ka like o nā mea hana a me ke kūleʻa e like me ke kuhikuhi ʻana no ka hoʻohana

Nā kumumanaʻo e ka hōʻike a me ke ʻano o ka hoʻohana

Ke poʻo inoa	He kumukūʻai ma Rusia	Kumukūʻai ma Ukraine
Lixumia lixisenatide	--	2498 UAH
Guanem guar gum	9950 ʻōpala	24 UAH
Hoʻopau ka Insvada	--	--
Novonorm Repaglinide	30 ʻōpala	90 UAH
Hoʻokomo ʻo Repodiab Repaglinide	--	--
Viktoza liraglutide	8823 kahaki	2900 UAH
Saxenda liraglutide	1374 ʻōpala	13773 UAH
Forksiga Dapagliflozin	--	18 UAH
Forsiga Dapagliflozin	12 ʻōpala	3200 UAH
Invocana canagliflozin	13 ʻōpala	3200 UAH
Jardins Empagliflozin	222 ʻōpala	566 UAH
Trulicity Dulaglutide	115 ʻōpala	--

Ka ʻokoʻa like, hiki ke pili pū i ka hōʻike a me ke ʻano o ka noi

Ke poʻo inoa	He kumukūʻai ma Rusia	Kumukūʻai ma Ukraine
Avantomed rosiglitazone, metformin hydrochloride	--	--
Bagometua Metformin	--	30 UAH
He metformin Glucofage	12 ʻōpala	15 UAH
Huʻi ʻia ka metformin xr	--	50 UAH
ʻO Reduxin Met Metinin, ʻo Sibutramine	20 ʻōpala	--
Dianormet	--	19 UAH
Metformin Diaformin	--	5 UAH
ʻO ke metformin metformin	13 ʻōpala	12 UAH
Metformin metozin metformin	--	13 UAH
Siofor	208 ʻōpala	27 UAH
ʻO ka metformin hydrochloride	--	--
ʻO Emnorm EP Metformin	--	--
Megifort Metformin	--	15 UAH
Metamine Metformin	--	20 UAH
Metamine SR Metformin	--	20 UAH
Metfogamma metformin	256 ʻōpala	17 UAH
ʻO Tefor metformin	--	--
Glycometer	--	--
Glycomet SR	--	--
Kālaiʻa	37 ʻōpala	--
Metformin Canon metformin, ovidone K 90, mauʻa palaoa, crospovidone, magnesium stearate, talc	26 ʻōpala	--
Insuffor metformin hydrochloride	--	25 UAH
Metformin-teva metformin	43 ʻōpala	22 UAH
Diaformin SR metformin	--	18 UAH
Mepharmil Metformin	--	13 UAH
Metformin Metformin	--	--
ʻO Glibenclamide Glibenclamide	30 ʻōpala	7 UAH
Maninyl Glibenclamide	54 ʻōpala	37 UAH
ʻO ka Glibenclamide-Health Glibenclamide	--	12 UAH
Glyurenorm glycidone	94 ʻōpala	43 UAH
ʻO Bisogamma Glyclazide	91 ʻōpala	182 UAH
ʻO Glidiab Glyclazide	100 rub	170 UAH
Diabeton MR	--	92 UAH
Diagnizide mr Gliclazide	--	15 UAH
ʻO Glidia MV Gliclazide	--	--
ʻO Glykinorm Gliclazide	--	--
Hoʻolaha ʻia Gliclazide	231 rub	57 UAH
Glyclazide 30 MV-Indar Glyclazide	--	--
Hoʻolaha-Hoʻolima Glyclazide-Health	--	36 UAH
ʻO Glioral Glyclazide	--	--
Hoʻolaha Glaclazide Diagnizide	--	14 UAH
Diazide MV Gliclazide	--	46 UAH
Osliklid Gliclazide	--	68 UAH
Gliclazide Diadeon	--	--
ʻO Glyclazide MV Gliclazide	4 ʻōpala	--
Amaril	27 ʻōpala	4 UAH
Glimepiride ʻO Glemaz	--	--
Hoʻolaha ʻia ka inoa momona	--	77 UAH
ʻO Glimepiride Glyride	--	149 UAH
Diapiride Glimepiride	--	23 UAH
Alarahi	--	12 UAH
Hoʻolālā ʻia ʻo Glimax	--	35 UAH
Gimepiride-Lugal glimepiride	--	69 UAH
Clay glimepiride	--	66 UAH
Glabepiride diabrex	--	142 UAH
Nā glimepiride ʻo Meglimide	--	--
Melpamide Glimepiride	--	84 UAH
ʻO ka glimepiride Perinel	--	--
Hoʻohui	--	--
Kahiʻu	--	--
Gimepiride glimepiride	27 ʻōpala	42 UAH
ʻO Glimepiride-teva glimepiride	--	57 UAH
Gimepiride Canon glimepiride	50 ʻōpala	--
ʻO Glimepiride Pharmstandard glimepiride	--	--
Dimaril glimepiride	--	21 UAH
ʻO Glamepiride diamerid	2 hoʻoheʻe	--
Amaryl M Limepiride Maikaʻi ʻia, Metformin Hydrochloride	856 ʻōpala	40 UAH
ʻO ka glibenclamide glibomet, metformin	257 ʻōpala	101 UAH
ʻO Glucovans glibenclamide, metformin	34 ʻōpala	8 UAH
Dianorm-m Glyclazide, Metformin	--	115 UAH
Dibizid-m glipizide, metformin	--	30 UAH
Douglimax glimepiride, metformin	--	44 UAH
Duotrol glibenclamide, metformin	--	--
Hoʻolauleʻa	45 kahi	--
Glibofor metformin hydrochloride, glibenclamide	--	16 UAH
Avandamet	--	--
Avandaglim	--	--
ʻO metumin metumin, sitagliptin	9 ʻōpala	1 UAH
Velmetia metformin, sitagliptin	6026 rub	--
Galvus Met vildagliptin, metformin	259 ʻōpala	1195 UAH
ʻO glimepiride Tripride, metformin, pioglitazone	--	83 UAH
Huihui XR metformin, saxagliptin	--	424 UAH
Metformin Comboglyz Prolong, saxagliptin	130 ʻōpala	--
Gentadueto linagliptin, metformin	--	--
ʻO ka metformin Vipdomet, alogliptin	55 ʻ .pū	1750 UAH
Sinjardi empagliflozin, metformin hydrochloride	240 ʻōpala	--
ʻO Voglibose Oxide	--	21 UAH
He pioglitazone Glutazone	--	66 UAH
ʻO Dropia Sanovel pioglitazone	--	--
ʻO Jasonvia sitagliptin	1369 ʻōpala	277 UAH
Galvus vildagliptin	245 ʻōpala	895 UAH
Onglisa saxagliptin	1472 ʻōpala	48 UAH
Nesina alogliptin	--	--
Vipidia alogliptin	350 ʻōpala	1250 UAH
Trazhenta linagliptin	89 ʻōpala	1434 UAH

Pehea e ʻike ai i kahi analogue ʻano maʻalahi o kahi lāʻau lapaʻau nui?

No ka ʻike ʻana i kahi analogue kūʻai like ʻole i ka lāʻau lapaʻau, kahi generic a i ʻole synonymation, ʻo ka mea mua mua mākou i manaʻo no ka hoʻolohe ʻana i ka hoʻopili ʻana, ʻo ia nā ʻano like ʻole o nā mea kaha a me nā hōʻailona no ka hoʻohana. Hōʻike ka mea like ʻole o ka lāʻau lapaʻau me ka lapaʻau a like pū me ka lāʻau lapaʻau, kūloko a me ka mea pono i ʻole nā lāʻau lapaʻau. Eia naʻe, mai poina e pili ana i nā māhele like ʻole o nā lāʻau like like, e hiki ai ke hoʻopilikia i ka palekana a me ka hana. Mai poina e pili ana i nā kauoha a nā kauka, hiki i ka lāʻau lapaʻau ponoʻī ke hōʻeha i kou olakino, no laila e ʻōlelo mau i kāu kauka ma mua o ka hoʻohana ʻana i kekahi lāʻau lapaʻau.

ʻO Glibenclamide

4 hāʻawi mai ka hoʻomaka ʻana 100.00 mamua 135.00 ʻōpala

4 hāʻawi mai ka hoʻomaka ʻana 112.00 mamua 126.00 ʻōpala

19 hāʻawi mai ka hoʻomaka ʻana 339.00 mamua 615.00 ʻōpala

ʻO 34 ka hoʻomaka ʻana 55.00 mamua 11,650.00 ʻōpala

27 hāʻawi mai ka hoʻomaka ʻana 48.00 mamua 178.00 ʻōpala

2 hāʻawi mai ka hoʻomaka 227.00 mamua 246.00 ʻōpala

Kūleʻa Glimepiride

1 hāʻawi mai ka hoʻomaka 180.00 mamua 180.00 ʻōpala

13 hāʻawi e hoʻomaka ana 147.00 mamua 376.00 ʻōpala

18 ʻo nā makana e hoʻomaka ana 290.00 mamua 436.00 ʻōpala

29 mai nā hoʻomaka ʻana 154.00 mamua 805.00 ʻōpala

11 hāʻawi mai ka hoʻomaka ʻana 97.00 mamua 345.00 ʻōpala

45 hāʻawi ke hoʻomaka ʻana 1,250.00 mamua 4,044.00 ʻōpala

Kuʻunaʻo Combogliz

18 ʻo nā makana e hoʻomaka ana 3,090.00 mamua 3,899.00 ʻōpala

10 hāʻawi mai ka hoʻomaka ʻana 1,425.00 mamua 1,959.00 ʻōpala

17 ʻo nā makana e hoʻomaka ana 1,469.00 mamua 1,767.00 ʻōpala

ʻO 63 hāʻawi mai 667.00 mamua 1,904.00 ʻōpala

19 hāʻawi mai ka hoʻomaka ʻana 1,749.00 mamua 2,189.00 ʻōpala

25 nā makana e hoʻomaka ana 689.00 mamua 1,369.00 ʻōpala

16 hāʻawi mai ka hoʻomaka ʻana 1,648.00 mamua 1,959.00 ʻōpala

Hōʻike ʻia nā kaila Baeta āpau no nā kumu ʻike a ʻaʻole wale ke kumu no ka hoʻoholo kūʻokoʻa ʻana i ka pono o ka pono o ka lāʻau. Ma mua o ka hoʻohana ʻana i ka lāʻau lapaʻau, e kamaʻilio me kāu kauka a heluhelu i nā ʻōkuhi no ka hoʻohana.

KOMOHANU POHOLOHOLOHE HOLOHE NEI

ʻO ka lāʻau lapaʻau Hypoglycemic Baeta: nā ʻōlelo no ka hoʻohana ʻana, nā kumukūʻai, nā loiloi a me nā analogues

ʻO Baeta kahi hoʻomākaukau synthetic e pili ana i ka waiwai exenatide, he hopena hypoglycemic.

Hoʻomaopopo kēia hopena ma o ka hoʻihoʻi ʻana i ka poʻe receptors o peptide like me ka peptide-1 a me ka hoʻoulu ʻana i ka synthesis o ke kumu o ka insulin e nā beta-cell o ka pancreatic gland, e kōkua ana i ka hoʻemi o ka glucose koko.

I waena o nā hopena hopena o Beat ʻo:

ka hoʻohaʻahaʻa i ke koko koko a me ka pale ʻana i ka hoʻomohala ʻana o nā hōʻailona o ka hyperglycemia,
i ka hoʻoemi ʻia ʻana o ka hana hoʻohanohano glucagon ma pane ʻana i ka hyperglycemia i nā mea maʻi me ka maʻi maʻamau 2,
lohi ana i ka hoʻomaha ʻana o nā ʻōpū o ka ʻōpū a hoʻopaʻa i ka pōloli.

Hōʻike ʻia ka lāʻau Beata no ka hoʻohana wale ʻana no nā mea maʻi e loaʻa nei i ka maʻi maʻamau ʻo type. Ua kauoha ʻia e hoʻokele i ka pae o ka glycemia i nā poʻe maʻi e loaʻa ana i ka mālama antidiabetic me nā derogative sulfonylurea a me ka metformin.

Nā hiʻohiʻona noi

Hoʻohana ʻia ka lāʻau lapaʻau i ka subcutaneously ma luna o ke kolu o luna a waena paha o ka poʻohiwi, ʻūhā, a i loko hoʻi o ka ʻōpū. ^ E Ha yM. Pēlā e like me ke kānāwai, ua ʻōlelo ʻia e hoʻololi i kēia mau pūnaewele i mea e haʻalele ai i ka hoʻokumu ʻana o nā konglomerates subcutaneous.

Pono e hoʻokō ʻia kēia maʻi e like me nā kānāwai āpau no ka hoʻohana ʻana i kahi peni syringe. Pono ka lā o ka lāʻau e mālama ai i hoʻokahi hola ma mua o nā kīʻaha nui ma waena o nā liʻiliʻi he 6 mau hola.

ʻAʻole hiki ke hoʻohui ʻia ʻo Exenatide me nā palapala hoʻohālikelike hou aku, e pale aku ai i ka hoʻomohala ʻana i ka hopena kūpono ʻole.

Pono ke kauka i hoʻōla i ka lāʻau, e pili ana i nā kuhikuhi e like me ka glucose koko, ka make o ka lāʻau hypoglycemic nui, ka hele ʻana o nā maʻi concomitant, a me nā mea like.

ʻO ka maʻamau ʻo ka hoʻomaka mua ʻana o Baeta he 5 mcg ʻelua mau manawa ʻelua i ka lā no nā pule ʻehā.

Eia hou, hiki ke hoʻonui ʻia ka nui o nā waihona i hoʻokahua ʻia no 10 μg i kēlā me kēia lā (inā pono). ʻAʻole ia e kauoha ʻia e ʻoi aku i kahi kaomi ma mua o 10 mcg.

Hōʻike ʻia nā hōʻailona o ka lāʻau overdose ma mua o 100 μg o ka waiwai i kēlā me kēia lā a ʻike ʻia e like me ka nui o ka luaʻi i ka wā o ka holomua o ka holomua hypoglycemia.

Exenatide: kumukūʻai a me nā kiko'ī o Bayeta

ʻO ka lāʻau lapaʻau Baeta, ʻo kāna mea ikaika e exenatide, ua manaʻo ʻia he lāʻau kūʻokoʻa hypoglycemic ʻokoʻa. Hoʻohana ʻia ka mea hana i ka mālamaʻana i nā maʻi maʻi type 2, ʻoi pū kekahi me ka luhi.

Hoʻohana pū ka maikaʻi o kēia lāʻau'ōnaehana me ka ʻoihana o ka hana nui, ʻoi aku ka hōʻemi i ka pae o glucose i loko o ke koko.

Hoʻonui ia i ka mea huna o ka insulin, a me ka hoʻoulu ʻana nō hoʻi i nā hua e hoʻohiolo ai:

hoʻonui i ka hana o nā pūlima beta pancreatic, e alakaʻi ana i ka hoʻonui ʻana o ka hana hana insulin,
hōʻemi i ka mea huna o ka glucagon, e hoʻonui ai i ka ʻike o ka glucose i loko o ka ate,
lohi i ka hoʻokuʻu i loko o ka ʻōpū.

ʻO kahi pōmaikaʻi nui o kahi mea like e like me ka exenatide ʻo ia ka hoʻonui ʻana i ka hana o ka insulin mai ka parenchyma, a laila oki i kona huna ʻana i ka wā e hoʻi mai ka pae ʻai koko i ka maʻamau.

No laila, ʻo ka maʻamau o ka hoʻomaka ʻana o kahi kūlana hypoglycemic i loko o nā kānaka ua aneane like ʻole.

Ma hope o ka komo ʻana o ka waiwai o ke kino o ke kanaka, hoʻomaka koke ʻo ia e hana a hiki i kahi pae kiʻekiʻe i kāna hana i loko o ʻelua mau hola. ʻO ka lōʻihi o ka exenatide he 24 mau hola, no laila, ʻo ka hoʻolahaʻana iā ia i hoʻokahi manawa i ka lā e hāʻawi i ka emi ʻana o ka hoʻāʻo ʻana i ka kō i ka manawa 24 mau hola.

Eia kekahi, hoʻēmi ka exenatide i ka momona o ke maʻi maʻi, ma muli o ia, e hoʻopau ai i ka ʻai, ke ʻano a ke kumu o ka ʻōpū o ka ʻōpū, a ʻaʻole wikiwiki loa ia.

No laila, ʻaʻole nā mea o kēia mea hoʻokūkū wale i ke kōpaʻa koko, akā kōkua pū kekahi e wehe i nā 4-5 kililima hou aku.

Exenatide 2 mg

Kauoha mai ka lawe ʻana i loko o kahi fri pākiha i Moscow a i ʻole Russia. Ka uku uku - kālā ma ke lawe ʻana! Ua hōʻike ʻia ke kumukūʻai ma luna. Ma luna o ka pākaukau! Hoʻopili ʻia nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana a me kahi palapala maikaʻi mai ka mea hana.

Hoʻohana ʻia kā mākou huahana e like me nā koi o ka EU GMP EU a me Kelemania Pauku 13 AMG kānāwai e hōʻoiaʻiʻo ana i ka maikaʻi a me ka palekana o ka lāʻau lapaʻau.

Aponoia e ka American FDA a me ka European Medical Agency.

Nā ʻōkuhi a Exenatide

Hoʻokumu ʻia ka wehewehe me ke kuhikuhi no ka hoʻohana ʻana, nā loiloi hoʻomanawanui a me nā hopena o nā hoʻokolohua maʻi.

ʻO Bidureon kahi lāʻau lapaʻau no ka hoʻokaʻawale i ke kōpaʻa koko i loko o nā poʻe maʻi pākē me nā maʻi maʻi type 2. Pono e hoʻohana pū ʻia me ka ʻaʻai a me ka hoʻomaʻamaʻa, a me kekahi mau lāʻau kūlohelohe āu e lawe nei i kēia manawa.

ʻAʻole ia i hōʻike ʻia no ka hoʻohana ʻana ma ke ʻano he ʻano nui i ka maʻi maʻi.

Hiki i kēia lāʻau lapaʻau:

hoʻemi nui ʻia ka pae o ka hemoglobin A1C i ke koko,
hoʻemi i kou paona, akā ʻo ka exenatin ʻaʻole ia ka lāʻau kaumaha momona!

Kūleale Kūleʻaleʻa Exenatide

Ua komo nā mea maʻi maʻi type 2 i ke aʻo ʻana i ka maikaʻi a me ka palekana o ka lāʻau. Ma hope o kahi mālama 24-pule o ka mālama a lākou i lawe ai iā Bidureon ma ke ʻano o 2 mg pākahi.

ua hoʻemi ʻia ka nui o ke kō koko koko i ka awelika a 1.6% (ka nui o ka pae mua - 8.5%),
lilo ka momona ma kahi awelika o 2,5 kg.

He mea nui e hoʻomanaʻo e pili ana i kēia lāʻau i manaʻo no ka liloʻana o ka momona!

Nā hana hana i ka hana

ʻO ka Bidureon kahi lohi e hoʻokuʻu mau nei i ka lāʻau. Hana ʻia ka hana ma kahi pākē he 7 lā. Ke kōkua nei kēia lāʻau lapaʻau i kou kino e hoʻokuʻu i kona insulin pono loa i ka wā e pono ai e hoʻohaʻahaʻa i nā nui o ke kō koko koko, ke kū nei i loko o ka hebedoma.

Aia i kēlā me kēia pā i nā microspheres (nā hua liʻiliʻi) i loaʻa nā ʻano mea kaha - exenatide,

Holo mālie kēia mau pōpoki i ka hoʻokuʻu ʻana i ka lāʻau lapaʻau i loko o kou kino ma ke ʻano o ka hebedoma e kōkua i ke kaohi ʻana i ke kō koko koko. Eia kekahi, ke lawe nei i ka lāʻau lapaʻau, hoʻēmi iki ka nui o ka hoʻowalewale a me ka makemake, kahi laʻa hiki ke hoʻēmi iki i ka paona.

No ka mea e lawe ai paha mai 6 a 7 mau hebedoma e hoʻokō ai i ke kiʻekiʻe o ka lāʻau i loko o ke koko, pono ia e hoʻomau i ka lawe ʻana i ka lāʻau lapaʻau e like me ke kauka.

Pehea e lawe ai i ka lāʻau. Kūlana aʻe ma ka ʻōlelo aʻoaʻo:

lawe mai i ka friji kahi pā i ke ʻano hoʻokahi me ka lāʻau lapaʻau,
holoi holoi kou mau lima
e kau i ka pūlohelohe, ka ʻeke a ka pahu, ka vial a me ka syringe ma luna o kahi maʻemaʻe.
lālau i ka pono a hōʻole i ka pāpale uliuli
Lawe i ka ipu, hoʻokaʻī i nā manawa he nui ma luna o ka wahi paʻakikī e hoʻonā i ka pauma,
e hoʻohana i kou manamana e huki i ka pāpale ʻōmaʻomaʻo, e haʻalele i ka hue.
lawe i ka peke pili a hoʻokahe i ka uhi (mai hoʻopuni i ka mea hoʻohui ʻona i loko,
e paʻa ana i ka peke pili lima ma ka lima hoʻokahi, e lawe i ka hue ma kekahi lima,
kaomi ma luna o ka hilo ma ka konohiki kala o ka ʻekepeke, a hoʻokiʻekiʻe,
lālau i ka syringe, me ka lima ʻē aʻe i paʻa i nā pākeke hina 2 i ka pāpale keʻokeʻo.
hōʻoki i ka pale ʻana (e akahele ʻole e paʻi i ka piston),
Lawe i ka hue me ka mea hoʻohui i hui ʻia i ka ʻulaʻula, e ʻoki i ka mea i hoʻopili ʻia i ka syringe a waiho aku.

Nui! I kēia manawa, e hoʻohui ʻoe i ka lāʻau a hoʻopiha i ka syringe. Ma hope o ke kāwili ʻana i ka lāʻau lapaʻau, pono ʻoe e hāʻawi i kahi ʻōlelo. ʻAʻole hiki iā ʻoe ke waiho i ka lāʻau lapaʻau i hui ʻia no ka hoʻokele ma ka wā ma hope.

e hoʻolei i ka piston me kou manamana a hiki i ka nalo ʻana,
aʻo ke kāʻei ʻana i ka piston ma lalo, e lūlū maikaʻi i ka hue a hiki i ka hoʻokaʻawale ʻana o ka ʻōpala a me ka pauka,
Puhi i ka hue a ke kuhikuhi nei ka syringe, hoʻomau i ka paʻa i ka piston,
akomi mālie i ka hue ma kahi ʻē aʻe
huki i ka piston i lalo aʻe o ka laina o ka laina i ka ʻā o ka pona - e neʻe kēia i ka lāʻau mai ka vial i ka syringe,
me kou lima ʻē aʻe, e kaomi aku i ka mea hoʻohui ʻona e hoʻokaʻawale iā ia mai ke syringe. E makaʻala e pale ʻole i ka piston,
e lawe i ka pūloʻu a kau i ka ʻāhane a hiki i ka nalo ʻana, ʻaʻole e hoʻokaʻawale i ka uhi.
lohi ikaika i ka piston ke kū i ka ʻaoʻao o luna o ka piston me ka laina kalaka ʻeleʻele e hōʻike ana i ke ʻano koi, e hoʻoneʻe i kou manamana lima mai ka piston,
e mālama i ka wahi i ʻōlelo ʻia me kahi puaʻa ʻona,
hopu i ka syringe ma ka wahi o ka laina i kapa ʻia i ka ʻeleʻele,
wehe i ka pāpale pale mai ka pono,
hoʻokomo i ka lāʻau lāʻau i ka pūnaewele injection (subcutaneously) a komo i kahi kaona piha o ka lāʻau lapaʻau e like me ke ʻano i kuhikuhi ʻia e kāu kauka.

Pehea e hōʻoia ai ua hoʻokele piha ʻia ka lāʻau lapaʻau?

E kaomi i ka piston a lohe ʻoe i kahi kaomi maoli. Ma hope o kēlā, kali iā 10 kekona. Ano hiki ke maopopo iā ʻoe ua hana pono ʻoe i nā mea āpau 🙂

I ke kauoha ʻana i kekahi mau puʻupuʻu e loaʻa ai iā ʻoe ka uku kūʻai:

2 pākēkē no: 400.00 €

3 mau pākolo no: 395.00 €

4 kāpae i ka: 390.00 €

5 mau pākolo i: 385.00 €

10 mau pākolo no: 375.00 €

Ka hana lāʻau lapaʻau

Ka lāʻau Hypoglycemic. ʻO Exenatide (Exendin-4) kahi mimetin mimetic a he 39-amino acid amidopeptide.

ʻO ka mea nui, e like me ka peptide like-glucagon-1 (GLP-1), e hoʻonui i ka huna ʻana i ka glucose o ka glucose, e hoʻomaikaʻi i ka hana cell cell, e kīpī i ka hoʻonui ʻia ʻana o ka pale me ka hoʻokaʻawale i ka ʻōpū ma hope o kā lākou komo ʻana i ke kaila ākea mai nā ʻōpū.

ʻO ka papa waikawa amino o ka exenatide mahele like me ka pakanui o ka GLP-1, ma muli o ia mea e nakinaki ai a hoʻonā i nā mea hoʻonaninani GLP-1 i loko o nā kānaka, e alakaʻi ana i ka synthesis-hilinaʻi nui o ka glucose a me ka huna ʻana o ka insulin mai ka pancreatic beta cells me ka komo ʻana o ka cyPic AMP a me / a i ʻole nā hōʻailona intracellular ʻē aʻe. ala.

Hoʻokomo ʻo Exenatide i ka hoʻokuʻu ʻana o ka insulin mai nā beta beta i mua o ka piʻi ʻana o ka glucose kiʻekiʻe. Hoʻolaha ka Exenatide i ka hana kemika a me nā hana pharmacological mai ka insulin, derivatives sulfonylurea, D-phenylalanine derivatives a me meglitinides, biguanides, thiazolidinediones a me alpha-glucosidase inhibitors.

Hoʻonui ka Exenatide i ka mālama glycemic i nā mea maʻi me ka maʻi type 2 no ka mea hana i kēia mau hana. I nā kūlana hyperglycemic, hoʻonui ka exenatide i ka huna ʻana i ka glucose i ka huna ʻana i ka insulin mai nā cell beta pancreatic.

Hoʻopau kēia mea huna i ka neʻe ʻana o ka hoʻokaʻawale ʻana o ke koko glucose a pili pono i ka maʻamau, ma laila e hōʻemi ai i ka hopena o ka hypoglycemia. ʻO ka huna ʻana o ka insulin i nā mau minuke 10 mua (e pane ana i ka hoʻonui ʻana o ka glycemia), i kapa ʻia ʻo ka "mana mua o ka pane ʻana i ka insulin." nā mea maʻi me ka maʻi diabetes type 2.

Eia kekahi, ʻo ka nalowale o ka pae mua o ka pane ʻana o ka insulin he ʻemi o ke ʻano o ka hana ʻana o ka beta cell e hana i ka maʻi diabetes type 2. Hoʻomaka hou ka mālama ʻana o ka exenatide i ka mua a me ka lua o nā lua o ka pane ʻana i ka insulin i nā maʻi maʻi me ka maʻi type 2.

I ka maʻi me ka diabetes type type 2 e kū'ē ana i ke kua o ka hyperglycemia, ke hoʻomalu nei ka hana o ka exenatide i ka mea huna nui o ka glucagon. Eia nō naʻe, ʻaʻole e hoʻopili ʻo exenatide i ka pane o ka glucagon maʻamau i ka hypoglycemia. Hōʻike ʻia ka alakaʻi ʻana o ka exenatide i kahi hoʻohaʻahaʻa i ka momona a me ka hoʻohaʻahaʻa ʻana i ka ʻai o ka meaʻai, ke kāohi i ka kaomi o ka ʻōpū, kahi e alakaʻi ai i ka lohi i kona hoʻokaʻina ʻana. I nā mea maʻi me ka diabetes type type mellitus, exenatide therapy e hui pū me ka metformin, thiazolidinedione a me / a i ʻole ka hoʻomākaukau ʻana i ka sulfonylurea hoʻomākaukau i ka emi ʻana o ka ʻai o ke koko glucose, glucose o ka lolo i ka postprandial, a me ka HbA1c, ma laila e hoʻomaikaʻi ai i ka mālama glycemic i kēia mau maʻi.

Lapaʻau lāʻau

Hoʻopau ma hope o ka hoʻomalu ʻana o ka exenatide ma loko o kahi inane o 10 μg i nā mea maʻi me ka diabetes mellitus type 2, ua hele koke ka exenatide a hōʻea i kahi C C ma hope o nā hola 2.1, ʻo ia ka 211 pg / ml, ʻO AUCo-inf ka 1036 pg? h / ml Ke kū nei i ka exenatide, hoʻonui nui ʻo AUC i ka nui o ka hoʻonui ʻana i ka hopena mai 5 μg a 10 μg, ʻoiai ʻaʻole i hoʻonui ka nui i ka Cmax.

Hoʻomaopopo ʻia ka hopena like me ka hoʻokele subcutaneous o exenatide ma ka ʻōpū, ka ʻūhā a mua pūpū. ʻO ka hoʻoili ʻana o Vd exenatide ma hope o ka hoʻokele sc ma ka 28.3 L. ʻO ka metabolism a me nā hoʻopiʻi Exenatide ka mea maoli i hoʻopili ʻia e ka filtration glomerular i ukali ʻia e ka proteolytic degradation. ʻO ka wehe ʻana o Exenatide he 9.1 l / h. ʻO ka hola T1 / 2 hope loa he 2.4 hola.

ʻO kēia mau hiʻohiʻona pharmacokinetic o exenatide he kūʻokoʻa kūʻokoʻa. Hoʻoholo ʻia nā mea hou o ka exenatide ma kahi o 10 mau hola ma hope o ka pau ʻana.

Pharmacokinetics i nā maʻi lapaʻau kūikawā Ma nā mea maʻi me ka hoʻowahāwahā a me ke kaulike māmā (CC 30-80 ml / min), ʻaʻole iʻokoʻa ka hoʻomaʻamaʻa o exenatide i kahi hoʻomaʻamaʻa i nā mea maʻi me ka hana maʻamau, no laila, ʻaʻole i koi ʻia ka hoʻoponopono ʻana o ka lāʻau.

Eia nō naʻe, i nā mea maʻi me ka hala ʻole o ka hope o ka renal i pau i ka dialysis, ua hōʻemi ʻia ka awelika maʻa he 0.9 l / h (hoʻohālikelike ʻia me 9.1 l / h i nā kumuhana olakino) ʻoiai ua exnatide ka nui o nā lālani, ua manaʻoʻiʻo ka hana lūlū o ka luhi i loli ʻole i ka hoʻololi ʻana o ka exenatide i loko o ke koko. ʻAʻole pili ka makahiki i ka maʻi pharmacokinetic o exenatide.

No laila, ʻaʻole i koi ʻia ka poʻe maʻi ʻōpiopio e hoʻokō i ka hoʻoponopono hoʻoponopono ʻia. ʻAʻole aʻo ʻia nā pharmacokinetics o exenatide i nā keiki ma lalo o 12 makahiki o nā makahiki. Ma kahi noiʻi pharmacokinetic i nā keiki'ōpiopio 12 a 16 mau makahiki me ka type 2 diabetes mellitus, i ka manawa i kauoha ʻia ai ka exenatide i kahi maʻi o 5 μg, ua like nā pālapa pharmacokinetic me ka poʻe pākeke.

ʻAʻohe ʻanoʻokoʻa ʻē aʻe i waena o nā kāne a me nā wahine i loko o ka pharmacokinetics o exenatide. ʻAʻole loli nā pharmacokinetics o exenatide i nā ʻelele o nā lāhui like ʻole. ʻAʻole koi ʻia ka hoʻoponopono ʻana ma ke ʻano ʻōiwi. ʻAʻohe mea hoʻomaopopo ma waena o ka index mass body (BMI) a me exenatide pharmacokinetics. ʻAʻole koi ʻia ka hoʻoponopono ʻana ma kahi BMI.

Nā kūlana kūikawā

Mai alakaʻi i ka lāʻau lapaʻau ma hope o ka ʻaʻa ʻana. ʻAʻole ia i kāpae ʻia i loko / a i ʻole i ka mana m / i ka lāʻau lapaʻau. ʻAʻole pono ke hoʻohana ʻo Bayeta® inā ua ʻike ʻia nā pōpoki i ka hopena a i ʻole ʻālamulu paha ka hopena.

Ma muli o ka nui o ka immunogenicity o nā lāʻau i loaʻa ka protein a me ka peptides, hiki ke hoʻomohala ka hoʻomohala ʻana o nā antibodies e exenatide i ka wā o ka mālama ʻana me Bayeta®. Ma ka hapa nui o nā poʻe maʻi e ʻike ʻia ai ka hana ʻana o ia mau ʻano antibodies, ua hoʻemi ʻia ka hapa o ko lākou titili ma muli o ka hoʻomau ʻia ʻana o ka lāʻau a hoʻomau ʻia ka haʻahaʻa o nā wiki 82.

ʻAʻole ka hopena i ka hopena o nā antibodies i nā ʻano a me nā ʻano o nā hopena like ʻole i hōʻike ʻia. Pono e hoʻomaopopo ʻia nā mea maʻi e pili ana ka mālama ʻana me Bayeta® i ka hoʻokaʻawale ʻana i nā mea momona a me / a i ke kaumaha ʻana paha o ke kino, a no kēia mau hopena ʻaʻole pono ke hoʻololi i ka noho aliʻi dosage.

Ma nā noi preclinical i loko o nā mehe a me nā kahe, ʻaʻole i ʻike ʻia ka hopena carcinogenic o exenatide.

I ka wā e noi ʻia ai kahi hopena ma nā ihe a 128 mau manawa i ka nui o ka nui o ka nui i loko o nā kānaka, ua ʻike ʻia kahi hoʻonui helu C-cell thyroid adenomas me nā hōʻailona ʻole o ka malignancy, ka mea i hui pū ʻia me ka hoʻonui o ka ola o nā holoholona hoʻokolohua e loaʻa i ka exenatide.

Ua hōʻike ʻia nā hihia i ʻole o ka hana i ʻole ke ahonui a me ka hoʻonui ʻana i ka serum creatinine, ka ulu ʻana o ka pilikia o ka renal, ʻo ka hopohopo ʻana i ka papa o nā hana a me ke kūleʻa o ka renal o ka hana ʻole, a i kekahi manawa ua hemodialysis.

Ua ʻike ʻia kekahi o nā hanana i ka poʻe maʻi e loaʻa ana i hoʻokahi aila i ʻole nā lāʻau lapaʻau e pili ana i ka hana renal / metabolism wai a me / a i ʻole e kūʻē i nā hanana ʻino ʻē aʻe e pili ana i ka hoʻōla, a like me ka pōhaʻi, hoʻopuka a me / a me nā maʻi. ʻO nā lāʻau lapaʻau hoʻohui e pili ana i ka hana ACE inhibitors, NSAIDs, a me diuretics.

Ke koho ʻana i ka maʻi hōʻailona a me ka hoʻokuʻu ʻana i ka lāʻau, hiki paha i ke kumu o nā loli pathological, ua hana hou ʻia ka hana renal impaired. Ke lawe nei i nā noi preclinical a me ka lāʻau lapaʻau o exenatide, ʻaʻole i loaʻa ka ʻike no ka nephrotoxicity pololei. Ua hōʻike ʻia nā hihia pālua o ka pancreatitis hoʻonā e lawe ana iā Bayeta®. Pono e hoʻomaopopo ʻia nā mea maʻi e pili ana i nā hōʻailona o ka maʻi o ka pancreatitis maʻa: mau loa ka maʻi ʻeha. I ka koho ʻana i ka therapyaticatic, nānā ʻia ka hopena o ka pancreatitis maʻa. ʻO nā mea maʻi ma mua o ka hoʻomaka ʻana i ka mālama ʻana me ka Bayeta® pono e hoʻomaʻamaʻa iā lākou iho me ke "alakaʻi no ka hoʻohana ʻana i kahi peni ʻoi" i hoʻopuni ʻia me ka lāʻau lapaʻau.

1 ml exenatide 250 mcg ʻO nā mea e loaʻa ai: sodium acetate trihydrate - 1,59 mg, acid acetic - 1.1 mg, mannitol - 43 mg, metacresol - 2.2 mg, wai d / i - q.s. a hiki i 1 ml.

Hoʻohui nūhou

Pono e hoʻohana ʻia ʻo Bayeta® me ka akahele i ka poʻe maʻi e hoʻomākaukau ana i nā mākau waha e pono ai ke komo ʻana o ka papa o ka gastrointestinal, e like me Hiki ke hoʻolōʻihi i ka Byeta® i ka pani ʻana i ka ʻōpū.

Pono e ʻōlelo ʻia nā mea maʻi e lawe i ka lāʻau lapaʻau waha, ka hopena o ka mea e pili ana i ka paepae paʻa o ka paepae (no ka laʻana, ka antibiotics) a ma kahi o 1 mau hola ma mua o ka hoʻokele ʻana o exenatide. Inā pono e lawe ʻia nā mea inu like me ka meaʻai, a laila e lawe ʻia i ka wā o ia mau meaʻai i ka wā ʻaʻole i hoʻokele ʻia nā exenatide.

Me ka mālama like o ka digoxin (0.25 mg 1 manawa /) me ka mākaukau Baeta®, ua emi ka nui o ka digoxin e ka 17%, a hoʻonui ʻia ʻo Tmax ma nā hola he 2,5 mau nō naʻe, ʻaʻole i loli ka AUC i ka mokuʻina o ka waiwai.

Ke kūʻē nei i ke ʻano o ka hoʻokele ʻana o Bayeta®, AUC a me Cmax o lovastatin i hōʻemi ʻia e ka nui o 40% a me 28%, kēlā me kēia, a ua hoʻonui ʻia ʻo Tmax ma kahi o nā hola he 4. ʻO ka hoʻokele ʻana o Bayeta® me ka HMG-CoA reductase inhibitors ʻaʻole i hui pū ʻia e nā loli e ka hui lipid aʻoaʻo.

Ke keu

Ma kahi o kahi overdose (pā i 10 mau manawa a ʻo ka nui i hoʻolako ʻia), ʻike ʻia kēia mau hōʻailona i ka maʻi: neʻeha a me ka luaʻi ʻana, a me ka emi wikiwiki hoʻi i ka pae o ka glucose o ke koko (hypoglycemia). Hoʻomaʻamaʻa: hōʻailona, me ke kākoʻo iv dexrose solution i ka hihia o ka hypoglycemia koʻikoʻi.