Insulin Isulin

Ka inoa kūʻai kalepa o ka hoʻomākaukau: Genetic engineering insulin-isophan (Insulin-isophan kanaka biosynthetic)

ʻOiai inoa ʻole inoa honua: Insulin + Isofan

Nā palapala ʻano: ka hoʻokuʻu ana no ka hoʻokele kūloko

Mea waiwai: isine + insulin

Hoʻolaha hui: ʻO ka hana hāmama waena

Hoʻolaha hana:

ʻO ka insulin hana hoʻopaʻa. Hoʻēmi i ka hoʻoliʻi o ka glucose i loko o ke koko, hoʻonui i kona ʻōhumu ʻana e nā kao, hoʻomaikaʻi i ka lipogenesis a me ka glycogenogenesis, ke kāpili ʻana o ka protein, e hoʻemi ana i ka huina o ka hana glucose i ka ate.

Hoʻopili ʻo ia me kahi kākākia kūikawā ma nā membrane waho o nā pona a hana i kahi mea hoʻonaninani o ka insulin. Ma ka hoʻonoho ʻana i ka synthesis o cAMP (ma nā pūlima momona a me nā pūpū o nā pona) a i ʻole ke komo pololei ʻana i ka pūpuna (nā ʻōpū), ʻo ka mea i hoʻohana ʻia e ka mea i hoʻohana ʻia e insulin mea hoʻouluulu i nā hana intracellular, komo synthesis o ka helu o nā enzymes koʻikoʻi (hexokinase, pyruvate kinase, glycogen synthetase, etc.). ʻO ka hoʻohaʻahaʻa o ka glucose i ke koko ma muli o ka hoʻonui ʻana o kāna kaomi intracellular, hoʻonui i ka hoʻihoʻi ʻana a me ka assimilation o nā ʻiʻo, hoʻoulu ʻana i nā lipogenesis, glycogenogenesis, protein synthesis, ka hoʻemi ʻana i ka hōʻemi o ka hana glucose i ka ate (ka hoʻēmi ʻana i ka wāwahi o glycogen), etc.

Ma hope o ke kaʻe scection, loaʻa i ka hopena i nā hola 1-1.5. ʻO ka hopena nui loa i ka waena ma waena o 4 mau hola 4, ʻo ka lōʻihi o ka hana he 11-24 mau hola, e like me ka mea o ka insulin a me ka hoʻoulu, e hōʻike ana i nā hōʻike inter-a me intra-pilikino pilikino.

Nā hōʻailona no ka hoʻohana ʻana:

ʻAno maʻi type 1.

ʻO ka maʻi mellitus type type 2, ka pale ʻana i ka lāʻau kūmole hypoglycemic waha, ka pale ʻana i ka mahele lāʻau i ka lāʻau hypoglycemic oral (hui pūnaʻi), nā maʻi kūlohelohe, nā hana hoʻihoʻi (mono- a i ʻole ka hui pū ʻana), ka maʻi mellitus i ka wā o ka hapai (me ka lāʻau hoʻomohala i ka maikaʻi ʻole).

Nā pālua:

Hypersensitivity, hypoglycemia, insulinoma.

Nā ʻoslelo a me ke hoʻoponopono:

P / C, 1-2 mau manawa i ka lā, 30-45 mau minuke ma mua o ka ʻaina kakahiaka (e hoʻololi i ka pūnaewele injection i kēlā me kēia manawa). I nā kūlana kūikawā, hiki i ke kauka ke kuhikuhi i kahi hōʻeha / m wai i ka lāʻau. I loko o / i ka hoʻolaha ʻana i ka insulin o ka lōʻihi medium ua pāpā ʻia! Kahi ʻia nā ʻōpona holoʻokoʻa a hilinaʻi ʻia i ka ʻike o ka glucose i ke koko a me ka urine, nā ʻano o ke ala o ka maʻi. ʻO ka maʻamau, ʻo nā dosis he 8-24 IU 1 ka manawa i ka lā. I nā mākua a me nā keiki me ka manaʻo kiʻekiʻe o ka insulin, kahi haʻahaʻa o lalo mai o 8 IU / lā e lawa paha, i nā mea maʻi me ka hoʻohaʻahaʻa iki - ʻoi aku ma mua o 24 IU / lā. I kahi lā maʻamau i kēlā me kēia lā he 0.6 IU / kg, - ma ke ʻano o 2 injections ma nā wahi like ʻole. ʻO ka poʻe maʻi e loaʻa ana i ka 100 IU a i ʻole i kēlā me kēia lā, ke ke hoʻololi nei i ka insulin, pono ke kipa ʻia i ka haukapila. Pono e hoʻoili ʻia mai kekahi lāʻau lapaʻau ʻē aʻe ma lalo o ka kaohi o ka glucose koko.

ʻElua hopena:

I ka hihia o ka mau hewa o ka dimen regdating, kaʻai ʻana, ka hoʻoweliweli kino nui, nā maʻi like ʻole, hiki i ka hoʻomohala ʻana o ka hypoglycemia, i nā hihia koʻikoʻi - precomatous and coma.

Aia paha: nā maʻi kūlohelohe, kūloko - ʻulaʻula a me ka haki, ka laulā - hopena anaphylactoid.

Hoʻopili ʻana me nā lāʻau lapaʻau ʻē aʻe:

Kūleʻa ʻole ka laila me ka hoʻonā o nā lāʻau ʻē aʻe. Hoʻonui ʻia ka hopena hypoglycemic e nā sulfonamides (me nā huaʻōlelo hypoglycemic waha, sulfonamides), ʻae ʻo MAO (e pili ana i ka furazolidone, procarbazine, selegiline), nā mākaʻi anhydrase carbonic, nā mea paʻa o ACE, nā NSAIDs (me ka salicylates), ka anabolic (komo i nā stanozolol, oxandrolone, methandrostenolone), androgens, bromocriptine, tetracyclines, clofibrate, ketoconazole, mebendazole, theophylline, cyclophosphamide, fenfluramine, Li + hoʻomākaukau, pyridoxine, quinidine, quinine, chloroquin, Hypoglycemic 'ole o ka hihia hoʻi glucagon, ulu hōmona, corticosteroids, ku una ha contraceptives, estrogens, thiazide Loop diuretics, BCCI, thyroid hormones, heparin, sulfinpyrazone, sympathomimetics, danazol, tricyclics, clonidine, kalipuna hakaka, diazoxide, Morphine, ka pakalōlō, nicotine i, phenytoin, epinephrine, H1-histamine receptor blockers.

Nā beta-blockers, reserpine, octreotide, pentamidine hiki i ka mea hou ke hoʻomaikaʻi a hoʻonāwaliwali i ka hopena hypoglycemic o ka insulin.

Ke waiho nei i nā kūlana no ka lāʻau lapaʻau:

I loko o ka friji, i ka mahana o 2-8 ° C (mai hoʻokaʻawale). E mālama i nā keiki.

Ka lā hiki: 2 makahiki

Mai hoʻohana ma hope o ka lā pau pau i hōʻike ʻia ma ka pahu.

Nā kūlana o ka ʻae ʻana mai nā lāʻau lapaʻau: Ma ke kumu

Mea Hana: ICN Jugoslavija, Yugoslavia