Baeta - nā ʻōlelo aʻoaʻo no ka hoʻohana

Ka puka ʻana - he hopena no ka ʻāhui ʻutanlelo subcutaneus (s / c): ka pulu, ʻili ʻole (1.2 a i ʻole 2.4 ml i loko o kahi pahu kāwili i hoʻokomo ʻia i loko o kahi syringe, i loko o ka pahu pepa 1 syringe pen a me nā ʻōlelo aʻo no ka hoʻohana ʻana iā Bayeta).

Ke kūmole o 1 ml o ka hoʻonā:

• hoonui ikaika: exenatide - 250 mcg,
• nā mea kōkua: metacresol, mannitol, acid acetic, sodium acetate trihydrate, wai no kahi maʻi.

Lapaʻau lāʻau

ʻO ka waiwai ikaika o Baeta he exenatide - kahi 39-amino acid aminopeptide, kahi mea e ʻike ai i nā kaola o ka polypeptide e like me koagonona.

He agonist ikaika ia o ka incretins, e like me ka glucagon like-peptide-1 (GLP-1), e hoʻomaikaʻi ana i nā hana o nā β-cells, hoʻomaikaʻi i ka huna ʻana i ka glucose glucose, e hoʻoulu i ka nui o ka huna ʻana i ka lolo, e hoʻolohi i ka hakahaka o ka ʻōpū (ma hope o ke komo ʻana i ka ʻōpū i loko o ke kaila maʻamau), a loaʻa nā hopena hypoglycemic ʻē aʻe. No laila, hiki i ka exenatide ke hoʻomaikaʻi i ka mālama glycemic i ka maʻi diabetes type 2.

Ka pilina amino amino o ka exenatide ma kekahi ākea e pili ana i ka pilina o ke kanaka GLP-1, e pili ana i ka lāʻau lapaʻau i nā mea hoʻokipa GLP-1 a hoʻoikaika iā lākou. A ke kumu, ua hoʻohui ʻia ka synthesis e pili ana i ka glucose a me nā mea huna o ka insulin mai i nā cells a sela o ka pancreas i ka komo ʻana o nā cyclic adenosine monophosphate (AMP) a me / a me nā ala e hōʻailona ana i loko o ka intracellular. Hoʻokumu ʻo Exenatide i ka hoʻokuʻu ʻana o ka insulin mai nā β-cell a inā he piʻi ka nui o ka glucose.

ʻOkoʻa ka Exenatide i ka hana kemika a me nā hana farmacological mai nā inhibitors alpha-glucosidase, sulfonylureas, insulin, biguanides, meglitinides, thiazolidinediones a me D-phenylalanine derivatives.

Hoʻoulu ʻia ka kontrol glycemic i ke ʻano type diabetes 2 e nā ʻenehana penei:

• Hoʻopukū ka glucose i ka inika insulin: e hoʻonui ka exenatide i ka huna ʻana i ka glucose o ka glucose mai ka pancreatic β-cell i nā mea maʻi me nā kūlana hyperglycemic. E like me ka nui o ka glucose i loko o ke koko, e emi ana ka nalo ʻana o ka inehina, ma hope o ka neʻe ʻana i ke kuʻuna, neʻe ia, ma laila e hōʻemi ai i ka hopena o ka hypoglycemia,
• ka hana mua loa o ka pane ʻana i ka insulin: i ka mellitus type 2 like ʻole, ʻaʻohe ʻano huna pilikino i ka wā 10 mau minuke mua. Eia kekahi, ʻo ka nalowale ʻana o kēia laʻana kahi mea pōkole o ka hana β-cell. Hoʻohana hou ka hoʻohana ʻana i ka exenatide hoʻomaikaʻi a hoʻomaikaʻi paha i nā mua a me ka lua o ka pane o ka insulin,
• ʻO ka hoʻonaʻauha ia o ke glucoseagon: ma ka hihia o ka hyperglycemia, ke kau aku nei ka exenatide i ka mea nui o ka ʻaihā o ka glucagon, ʻoiai ʻaʻole mau hewa i ka pane ʻana o ka glucagon maʻamau i hypoglycemia,
• ʻaina meaʻai: exenatide hoʻēmi i ka momona a, me ka hopena, ka nui o ka meaʻai i hoʻopau ʻia,
• gasting uhi: ke kāohi ʻana i ka ʻōpū o ka ʻōpū, exenatide lulu i kahi paʻa.

ʻO ka hoʻohana ʻana o ka exenatide type 2 diabetes mellitus i hui pū me ka thiazolidinedione, metformin a me / a i ʻole ka hoʻomākaukau ʻana i ka sulfonylurea e hōʻemi i ka hoʻokaʻa ʻana o ke koko a me ka glucose o ka postprandial, a me ka hemoglobin A1c (Hb_{A1c hoowela}), e hoʻomaikaʻi i ka mana glycemic.

Lapaʻau lāʻau

Ma hope o ka hoʻomalu sc, ua loaʻa koke iā exenatide. Ka awelika helu ʻai (C_max) ua loaʻa i loko o 2.1 mau hola a i kahi o 211 pg / ml.

ʻO ka wahi ma lalo o ka pihi o ka paʻa-manawa (AUC) ma hope o ka hoʻokele sc o ka exenatide ma kahi maʻa o 10 μg - 1036 pg × h / ml, hoʻonui kēia hōʻailona i ka hoʻohālike i ka hoʻonui ʻana i ka make, akā ʻaʻole ia i hoʻopilikia iā C_max. ^ E Ha yM. Hoʻomaopopo ka hopena like me ko s / i ka hoʻomaka ʻana o Baeta ma ka poʻohiwi, ka ʻōpū a i ʻole ʻūhā.

Ka Hoʻolaha Mahele (V_{e d}) aia no aneane 28.3 lita. Hoʻokuʻu ʻia ia ma ka kānana glomerular i ukali ʻia ma ka decomposition proteolytic. ʻO ka hoʻomaʻemaʻe e pili ana i 9.1 l / h. Ma ka hapalua o ke ola (T_½) - mau hola 2.4.

Hoʻoholo ʻia nā mea i hoʻopaʻa ʻia ma kahi o 10 mau hola ma hope o ke kaʻina o ka hopena exenatide.

Pharmacokinetics i nā hihia kūikawā:

• hana 'īa hoʻomaikaʻa' ia: i mea e hōʻike 'ole' ia ai i hana 'ole ma ka hoʻolaha' ana i hana 'ole i hana' ia (CC) 30-80 ml / min, i nā 'ike nui loa i nā pharmacokinetics o exenatide,' aʻole nā ​​mea e koi 'ia. I nā mea maʻi me ka hiki ʻole o ke alakaʻi ʻana o ka laikila i pau i ka dialysis, ke hoʻopau nei i ka lāʻau i ka palena o 0.9 l / h (i nā maʻi maʻi - 9.1 l / h),
• functioning atay impaired: mau ʻokoʻa mea i loaʻa i ka plasma o ka exenatide i loaʻa ʻole, ʻoiai ua pau ka lāʻau i ka nui o nā keiki,
• makahiki: ʻaʻole i aʻo ʻia nā pharmacokinetics o exenatide i nā keiki, i ka wā ʻōpio 12–16 makahiki o ka makahiki me ka maʻi diabetes mellitus type 2, i ka wā e hoʻohana ai ka exenatide ma kahi pākēnē o 5 μg, nā lāʻau lapaʻau pharmacokinetic e like me nā mea maʻi ua hōʻike ʻia, ma ka poʻe ʻelemakule ʻaʻohe loli i nā ʻano pharmacokinetic. koi ana
• ke kāne a me ka lāhui: nā hopena nui i ʻike ʻia i ka pharmacokinetics o exenatide ma waena o nā wahine a me nā kāne, ʻaʻole ʻike ʻia ka hopena o kēia lāhui.
• kaupaona kino: ʻaʻole i loaʻa ka hopena koʻikoʻi ma waena o ka waihona kikoʻā o ke kino a me ka exenatide pharmacokinetics i loaʻa.

Nā hōʻailona no ka hoʻohana ʻana

Ma ke ʻano he monotherapy no ka maʻi maʻamau o ka lā 2, hoʻohana ʻia ʻo Bayete i ka hoʻohui ʻana i ka lāʻauʻai a me ka hana e hoʻokō ai i ka mana o ka glycemic kūpono.

I ka hui pū ʻana o ka maʻi mellitus type 2, ua hoʻohana ʻia ʻo Bayete e hoʻomaikaʻi ai i ka mana glycemic i loko o nā mea penei:

• i ka hoʻohui i metformin / sulfonylurea derivative / thiazolidinedione / metformin hui + sulfonylurea derivative / metformin + thiazolidinedione hui,
• i ka hoʻohui i ka hui pū ʻana i ka pono basal + metformin.

Pākuʻi helu

ʻO ka hoʻonā no ka hoʻokele subcutaneous.

1 ml o ka hoʻonā i loaʻa:

mea ikaika: exenatide 250 mcg,

nā mea hoʻowalewale: sodium acetate trihydrate 1.59 mg, acetic acid 1.10 mg, mannitol 43.0 mg, metacresol 2.20 mg, wai no ka ʻomaʻi q.s. a hiki i 1 ml.

ʻĀnō pololi poloka.

ʻO nā hiʻohiʻona maʻamau o ka lāʻau

ʻO ka lāʻau lapaʻau ʻo Baeta he hana kuhi ʻole no ka subcutaneous infusion. ʻO ka mea hana a ka mea lapaʻau he exenatide, loaʻa nō hoʻi i kahi mea liʻiliʻi o ka sodium acetate trihydrate, metacresol, mannitol, acetic acid, ka wai aʻa. Hoʻokuʻu lākou i ka lāʻau lapaʻau i ke ʻano o nā ampoules (250 mg), loaʻa kēlā me kēia peni syringe kūikawā me ka nui o ka 1,2 a me ka 2.4 ml.

ʻO ka poʻe maʻi e lawe nei i kēia lāʻau lapaʻau e nānā i ka emi ʻana o ke kō o ke koko ma muli o kēia ʻano hana:

1. Hoʻonui ʻo Byeta i ka hoʻokuʻu ʻana i ka insulin mai ka parenchyma me ka hoʻonui nui o ka glucose i ke kahe koko o kekahi kanaka.
2. Kūʻai ka huna huna Insulin i ka manawa inā loaʻa ka emi o ke kō.
3. ʻO ka hana hope loa e hoʻomau i nā kaila koko.

I ka poʻe e ʻeha ana i kahi lua o ka maʻi maʻi, ʻo ka hoʻohana ʻana i ka lāʻau lapaʻau e alakaʻi i kēlā mau loli.

• Ke kāohi nei i ka hoʻonui ʻana o ka hana momona glucagon, ka mea e keakea nei i ka insulin.
• Ka hoʻonāukiuki o ka maʻi o ka gastric.
• Hoʻemi i ka momona.

Ke lawelawe ʻia nei ka lāʻau lapaʻau e ka subcutaneously, hoʻomaka ke hana ikaika e hana koke a hiki i kona kūlana kiʻekiʻe ma hope o ʻelua mau hola.

Hoʻopau kūʻokoʻa ka hopena o ka lāʻau i hope o kahi lā.

Nā ʻōkuhi no ka hoʻohana ʻana i ka lāʻau lapaʻau

ʻO ke kauka hele wale nō e hiki ke kuhikuhi i ka lāʻau lapaʻau, ʻaʻohe hihia e hoʻōla pono iā ʻoe iho. Ma hope o ka loaʻa ʻana o ka lāʻau lapaʻau Baeta, pono e ʻike pono ʻia nā ʻōkuhi no ka hoʻohana ʻana.

Ke hōʻike nei no ka hoʻohana ʻana i kēia lāʻau lapaʻau type 2 ʻano maʻi me ka lāʻau mono- a i ʻole hoʻoponopono hoʻoponopono ʻia. Hoʻohana ʻia ia i ka wā hiki ʻole ke hoʻokele kūpono i ka pae o ka glycemia. Hiki i ka lāʻau lapaʻau ke hoʻohui pū me ia mau ʻano:

1. Metformin
2. Thiazolidinedione,
3. Ololi Holi,
4. ka hui pū me ka metformin, sulfonylurea,
5. ka hui ʻana o ka metformin a me thiazolidinedione.

ʻO ka hopena o ka hopena o 5 μg ʻelua mau manawa i ka lā no kahi hola ma mua o ka lawe ʻana i ka ipu nui. Hoʻopaʻi ʻia ia i ka subcutaneously i loko o ka manamana, ʻūhā a me nā ʻōpū paha. Ma hope o kahi mahina o ka hoʻokō kūleʻa, e hoʻonui ʻia ka dosage i 10 mcg ʻelua i ka lā hoʻokahi. Inā hoʻohana ʻia ka lāʻau lapaʻau i hui pū me ka derivatives sulfonylurea, pono e hoʻemi ʻia ka nui o ka hopena e pale ai i ke ʻano hypoglycemic maʻi.

Pono e nānā ʻia nā lula no ka lawelawe ʻana i ka lāʻau.

• ʻaʻole hiki ke lawelawe ʻia ma hope o ka ʻaina.
• ʻaʻole pono e hoʻokomo i ka intramuscularly a i ʻole intravenously,
• inā he kinopou a ʻōlelo ʻia ke kala, akā ʻoi aku ka maikaʻi.
• inā loaʻa nā lālā i ka hopena, pono ʻoe e kāpae i ka noho ʻana o ka lāʻau lapaʻau,
• i ka wā ʻo Bayeta therapy, hiki ke hoʻāla ʻia nā antibody.

Pono ka mālama ʻia o ka lāʻau i kahi wahi i pale ʻia mai ka mālamalama a mai nā keiki liʻiliʻi. Pono e mālama ʻia ke aniani o ka mālama mai i ka pae mai 2 a 8 mau kiʻekiʻe, no laila ʻoi aku ka maikaʻi o ka mālama ʻana i ka lāʻau lapaʻau i loko o ka friji, akā mai hoʻokaʻawale.

ʻO 2 mau makahiki ka ola o ka puʻina o ka huahana, a ʻo ka hoʻonā ʻana i nā syringe peni he 1 mau mahina ma ke kau ʻana ma mua o 25 mau kiʻekiʻe.

E hoʻokuʻu i ke ʻano, ka hoʻonohonoho ʻana a me ka pōpoki

ʻO ia ka hopena no ka hoʻokele subcutaneous. I loko o ka syringe peni hiki ke 1,2 a me ka 2.4 ml o ka waiwai hana. ʻO ka pā i ka pā penehina hoʻokahi.

Aia i ka pūhui kekahi:

• exenatide -250 mcg,
• sodium acetate trihydrate,
• huehue acacial acae,
• mannitol
• metacresol
• wai no ka uliaa.

ʻO "Baeta Long" kahi lōpiopio no ka hoʻomākaukau no ka hoʻokuʻuʻana, kūʻai ʻia me ka uku kūpaʻa. ʻOi aku ke kiʻekiʻe o ke ʻano o kēia ʻano lāʻau lapaʻau, hoʻohana pinepine ʻia ʻo ia mau manawa. Hoʻohana wale ia ma ka subcutaneously wale nō.

Ka hana lāʻau lapaʻau

Loaʻa i kahi hopena hypoglycemic. Hoʻonui koʻikoʻi nui i ka kaohi koko glucose, ka hoʻolālā i ka hana o nā cell beta pancreatic, pani i ka huna nui ʻana o ka glucagon, hoʻomaikaʻi i ka huna ʻana o ka glucose i ka glucose a e hoʻohiolo i ka gastric waʻa.

ʻOkoʻa nā Exenatide i ka hoʻopili ʻana mai ka insulin, sulfonylurea a me nā mea ʻē aʻe, no laila ʻaʻole hiki ke lilo iā lākou ke loli i ka mālama ʻana.

ʻO ka poʻe maʻi e lawe ana i ka lāʻau lapaʻau Bayeta e hoʻohaʻahaʻa i ko lākou makemake, kāpae ka loaʻa ʻana o ke kaumaha, a me ka manaʻo o ka maikaʻi loa.

Nā Hoʻohui

• Hypersensitivity o nā māhele,
• ʻO nā maʻi koʻikoʻi o ka papa gastrointestinal me ka gastroparesis concomitant,
• ʻO ka mōʻaukala maʻi ketoacidosis,
• ʻOi aku ka hopena o ka pilikia.
• ʻAno maʻi type 1
• ʻŌpū a me ka lactation
• Aia ma lalo o ka makahiki 18 i lalo iho.

Nā ʻōkuhi no ka hoʻohana (ʻano a me ke ʻano)

Hoʻohana ʻia ka lāʻau lapaʻau ma ka ʻōpū, ka poʻohiwi, ke kihi a me nā ʻokiʻoki. Pono e hoʻololi ʻia ka pūnaewele injection. E hoʻomaka me ka helu ʻana o 5 mcg ʻelua mau manawa ʻelua ma mua o ka papaʻaina. Hiki iā ʻoe ke hoʻonui i ka nui i ka 10 mcg ʻelua mau manawa i kahi lā ma hope o 4 mau pule, inā e hōʻike ʻia. Me ka hopena hui, pono ʻia ka hoʻoponopono ʻana o ka sulfonylurea a me nā derivatives i ka insulin.

Nā hopena hopena

• ʻO ka hypoglycemia (me ka hoʻohui ʻana o nā hana),
• Hoʻemi i ka momona
• ʻĀpepa
• Hoʻokomo ʻia ʻo Gastroesophageal,
• Hoʻopilikia ka ʻike,
• ʻEha ka ʻōpū
• Nausea, luaʻi,
• Nā maʻi maʻi
• Kaaudeana
• KeHulelehe
• ʻEhaʻeha
• ʻʻAla
• Laumapa
• Nā ʻōnaehana kūloko,
• Nā maʻi kūloko kūloko ma nā wahi i ʻōlelo ʻia.
• Anaphylactic shock,
• Hyperhidrosis,
• Naʻu?
• Nā pancreatitis acute (loaʻa hoʻokahi)
• Kekuhi renal huʻu (hemahema).

Ke keu

Hiki i kēia mau hōʻailona me ka overdose:

• Hypoglycemia. Ke hōʻike nei ʻo ia iho i ka nāwaliwali, hoʻomehana a me ka luaʻi, ʻike ʻole i ka poʻohiwi a hiki i kona nalowale a me ka hoʻomohala ʻana i ka coma, pōloli, hōʻeha, a me nā mea haʻahaʻa o ka haʻahaʻa, ua lawa ia e ʻai i kahi huahana me nā momona o ka aʻe. Ma ka hihia o ka hypoglycemia maʻalahi a me ke kaumaha, e pono ai ke kauoha i ka ʻaila o glucagon a i ʻole ka dextrose. A laila e noʻonoʻo pono ʻoe e hoʻopili i kahi loea no ka hoʻoponopono hoʻoponopono ʻia.
• ʻO ke kūlana maikaʻi loa, ka hele pūʻana me ka maʻi a me ka luaʻi. Hoʻolahalaha ʻia ka mālama maʻi lapaʻau, hiki ke mālama ʻia i ka hoʻokipa.

Hoʻohui nūhou

E kūkākūkā ʻoe me kāu kauka e lawe i nā lāʻau lapaʻau e koi ai i ka hoʻokaʻawale koke ʻana mai ke kumu ʻeha o ka gastrointestinal, ʻoiai ʻo "Baeta" e lohi ana i ka ʻōpū o ka ʻōpū a ma muli o ka hopena o ka lāʻau.

Pono e hoʻohana ʻia nā lāʻau Antibiotics a me nā mea like like me 1 mau hola ma mua o ka hiki ʻana mai o ka "Bayeta" a i ʻole i ka wā o ia mau meaʻai i hoʻohana ʻole ʻia ai ia lāʻau.

Hoʻemi i ka hoʻoneʻe o digoxin, lovastatin, hoʻonui i ka manawa o ka nui o ka lisinopril a me nā warfarin.

Ma keʻano holoʻokoʻa, ua ʻike ʻia ka hopena o ka hopena o nā lāʻau lapaʻau ʻē aʻe. ʻAʻole kēia e ʻōlelo i kekahi mau hōʻailona hoʻoweliweli i hoʻomaopopo ʻia i ka wā o ka hoʻokele ʻana. No laila, ke nīnau kūkākūkā i ka nīnau o ka hoʻohui ʻana i ka lāʻau Bayetoy me nā lāʻau ʻē aʻe me ke kauka i hele mai.

Nā ʻōlelo kikoʻī

ʻAʻole keʻena ʻia ma hope o kahi pāʻina. Mai hōʻino i ka luhi a intramuscularly paha.

Inā he mea i hoʻokuʻu ʻia i loko o ka hopena a i ka paha paha, ʻaʻole pono ke hoʻohana i ka lāʻau lapaʻau.

Ua hōʻike ʻia ma ke ʻano o ka lāʻau lapaʻau e pili ana i ke kaumaha o ke kino, e hōʻemi ana i ka momona.

ʻAʻole hoʻohana ʻia i ka poʻe me ka maikaʻi ʻole o ka hana ʻole.

Hiki iā ia ke kumu i ka pancreatitis, akā ʻaʻohe ona hopena carcinogenic.

Pono ka mea maʻi e nānā i ka hoʻololi i ko lākou olakino i ka wā e mālama ai. Me ka hoʻomohala ʻana i nā kūlana koʻikoʻi, pono ʻoe e nīnau koke i ke kauka a kāpae i ka lawe ʻana.

ʻAʻole hoʻohanaʻia e like ma kahi o ka insulin.

I ka wā e hui pū ai me ka metformin a i ʻole sulfonylurea, hiki ke hopena i ka hiki ke lawe i kahi kaʻa. Hoʻoholo ʻia kēia pilikia me kāu kauka.

HELE. Hoʻokuʻu ʻia ka lāʻau lapaʻau ma o ka lāʻau wale nō!

Hoʻohana i ke wā ʻōpio a me nā makahiki kahiko

ʻAʻohe ʻikepili e pili ana i ka hopena o ka lāʻau lapaʻau ma ke kino o nā keiki ma lalo o ka 18 mau makahiki o laila, no laila, ʻaʻole i hoʻohana ʻia no kā lākou lāʻau. ʻOiai aia keʻike i ka hoʻohana ʻana i nā keiki mai nā makahiki 12, ua like nā hōʻailona like me nā mea pākeke. Akā e kuhikuhi pinepine ʻia nā ʻano ʻē aʻe.

Hiki ke hoʻohana e mālama i ka maʻi maʻi i nā maʻi maʻi maʻi. Eia nō naʻe, pono ʻoe e nānā i ke ʻano o ia poʻe i loaʻa ka mōʻaukala ketoacidosis a i ʻole he renal function renal. Hoʻomaopopo ʻia kēlā mau maʻi e hana pinepine i nā hoʻokolohua.

Hoʻohālikelike me nā lāʻau like ʻole

Loaʻa i kēia lāʻau lapaʻau nā analogues e hiki ke hoʻohana e mālama i ka maʻi maʻi. E noʻonoʻo pono i kā lākou mau waiwai i nā kikoʻī.

Hiki wale ke hoʻohana ʻana i nā metala me ke ʻae a ke kauka komo. Ua papa ʻia ka lāʻau lapaʻau pilikino!

Nānā ka poʻe i hiki ke loaʻa ka hopena o ka ʻaoʻao, i ka nui o ka nui me nā koho kūpono ʻole. Ua haʻi ʻia ka hopena o ka lawe ʻana i ke kaupaona ʻana, ʻoiai ʻaʻole ma nā āpau. Ma ke kuʻuna nui, nā “Bayeta” loaʻa nā loiloi maikaʻi o ka maʻi maʻi me ka ʻike.

Alla: “Ua ʻelua makahiki wau i hoʻohana i ka lāʻau.I loko o kēia manawa, hoʻihoʻi ka gula i ka maʻamau, a ua hōʻemi ke kaumaha i ka 8 kg. Makemake wau e hana wikiwiki a ʻaʻohe ʻaoʻao. E kuhikuhi aku wau ia oe. "

Oksana: "Baeta" kahi lāʻau lapaʻau nui, akā kōkua ia i ka maʻi maʻi maʻi. Mālama ka Sugar i ka pae like, kahi aʻu e ʻoliʻoli nui ai. ʻAʻole hiki iaʻu ke ʻōlelo he nui ka hoʻemi ʻana i ke kaupaona, akā ma ka liʻiliʻi e oki wau i ka hoʻōla ʻana. Akā ʻoi aku ka ʻiʻo o ka ʻono. Makemake wau eʻai liʻiliʻi, a no laila ua lōʻihi ka paona ma ka pāʻina like. I ka laulā, ua ʻoluʻolu wau i kēia lāʻau lapaʻau. ”

Igor: “Ua kuhikuhi lākou i kēia lāʻau lapaʻau no ka mālama ʻana i ka wā i pau ai kaʻu mau lāʻau kahiko. Ma keʻano holoʻokoʻa, kūpono nā mea āpau, koe wale no ka uku kiʻekiʻe. ʻAʻole i loaʻa ka "Bayetu" i nā pōmaikaʻi, pono ʻoe e kauoha i mua. ʻO kēia wale nō ka pilikia. ʻAʻole wau makemake e hoʻohana i nā kikowaena, akā ʻo ka mea pono. ʻOiai hiki iaʻu ke hoʻomaopopo ua ʻike koke au i ka hopena - he mau minuke wale nō ma hope o ka hoʻomaka ʻana o ka pau. Pau ka momona, no laila ua nalo aku ke kaumaha ma ka manawa like. "

Hoʻohālikelike

ʻO "Baeta" kahi lāʻau lapaʻau maikaʻi e kaulana i waena o nā mea maʻi me ka maʻi maʻi. ʻOi ka hoʻohālikelike ʻia i ka wā e pau ai nā lāʻau i ka hana. A hoʻopau ʻia ke kumukūʻai kiʻekiʻe e nā hopena hou o ke kaupaona ʻana a me kahi hōʻike maʻamau o nā hopena ʻeha i nā maʻi e hoʻomaʻamaʻa ʻia. No laila, ʻokoʻa ka maikaʻi ʻo “Bayeta” mai nā mea e hoʻohana ana i ka lāʻau lapaʻau a me nā kauka.

Nā hōʻailona a me nā contraindications

Ua hōʻike ʻia ka hopena o ka lāʻau i nā hoʻokolohua ʻeā 6 i hoʻopaʻa ʻia kahi hoʻohālikelike o kahi exenatide (2 mg) me nā lāʻau ʻē aʻe. Hāpai kēia mau haʻawina i ka poʻe i loaʻa i ke ʻano maʻi lapaʻau maʻamau (kaʻai + hana kino, i kekahi manawa me ka lāʻau lapaʻau mua). Loaʻa ka poʻe maʻi i ka HbA1c ma waena o 7.1 a me 11% a me kahi paona kino paʻa me kahi BMI o 25 a 45 kg / m2.

Hoʻohālikelike ʻelua mau hoʻohālikelike wehe i ka lāʻau 30 a 24 mau pule paha. Ka huina o ka poʻe 547, ma luna o 80% o lākou ka mea i lawe i ka metformin a me sulfonylurea a i ʻole pioglitazone, i komo i ka hana. Hāʻawi ke kākoʻo hoʻihoʻi-hoʻokuʻu i ka hopena maikaʻi loa e pili ana i ka HbA1c: Ua hōʻemi ʻia ka HbA1c e ka 1,9% a me 1,6%.

I loko o kahi noiʻi ʻelua ʻelua i mau i 26 mau pule, ua hoʻohālikelike nā kānakaʻepekema i sitagliptin, pioglitazone, a me exenatide. ʻO nā noiʻi ka pili ʻana i 491 mau poʻe i pane ʻole aku i ka mālama ʻana me ka metformin. I ka wā e mālama ʻia ai me ka exenatide, ua hōʻemi ʻia ka ʻike o HbA1c e ka 1,5%, ka mea i ʻoi aku ka kiʻekiʻe ma mua o ka pioglitazone a me sitagliptin. Ke lawe nei ʻo "Bayeta", hōʻemi ʻia ke kino kino e 2.3 kg.

Hoʻopilikia ka lāʻau lapaʻau i ka wā o ka wā hāpai a me ka lactation. Inā hoʻolālāʻia ka hapai, hiki i ka lāʻau ke hoʻokuʻu i ka liʻiliʻi ma mua o 3 mau mahina ma mua. ʻAʻole hiki i nā mea maʻi ma lalo o ka 18 mau makahiki ke hoʻohana i ka huahana no ka mea ʻaʻole i aʻo ʻia i kēia ʻōpio. Me ka hikiʻole o ka pale, loaʻa ka nui o nā hopena o ka hopena. ʻO nā mea maʻi me ka cleinine clearance ma lalo o 30 ml / min ʻaʻole pono e loaʻa ka lāʻau lapaʻau.

ʻO kahi lāʻau lapaʻau e pono ke hoʻokele ʻia i hoʻokahi manawa wale i ka hebedoma. Ma kekahiʻaoʻao, kahi lāʻau e waiho ana i loko o ke kino no ka liʻiliʻi ʻo 10 mau hebedoma nō hoʻi i loaʻa ka pono no nā pilikia lōʻihi.

Hoʻohui

Hiki i ka exenatide ke hoʻopilikia i ka gastric motility, helu a me ka nui o ka lawe ʻana o nā lāʻau lapaʻau'ē aʻe. Hiki i kahi lāʻau lapaʻau ke hoʻonui i ka hopena o ka hypoglycemia i ka wā e lawe ai i ka insulin a me ka sulfonylurea. Ua hōʻike ʻia ka hoʻohana pū ʻana o ka anticoagulants waha e hōʻemi i ka ʻaila koko.

ʻO nā mea kikoʻī nui (me nā mea like like) o ka lāʻau lapaʻau:

ʻO ka manaʻo o ka mea maʻi a me ke kauka e pili ana i ka lāʻau lapaʻau.

Ua kuhikuhi aku i ke kauka i nā pōpoki, no ka mea, ʻaʻole i hana ka lāʻau lapaʻau. Pono wau e ʻōlelo koke aku - he kumu kūʻai nui loa. He pono e kūʻai au i kekahi mau ʻeke, he kumukūʻai kumukūʻai. Akā, pono nā hopena e kūʻai - ua hoʻomaikaʻi maikaʻi ke kūlana. ʻAʻohe oʻu hopena maikaʻi ʻole. Hōʻike ka mika i nā waiwai maʻamau no kekahi mau mahina.

"Baeta" kahi lāʻau lapaʻau kūʻai i kuhikuhi ʻia no ka hikiʻole o nā lāʻau lapaʻau antidiabetic. ʻO ka hoʻohana lōʻihi (e like me nā alakaʻi kūhelu) hiki i ka nui o ka hōʻuluʻulu ʻana o ka maʻi glycemia a hoʻomaikaʻi i ke ʻano o nā maʻi, akā, "kūpono" ia.

ʻO Boris Alexandrovich, ka mea maʻi ma ka maʻi maʻi

Kumukūʻai (ma ke Lūkini Russian)

ʻO ke kumu kūʻai o ka mālama ʻana he 9000 rubles no 4 mau pule. ʻO nā lāʻau lapaʻau antidiabetic ka uku nui loa, ʻo ka metformin (ka nui, 2 g / lā) ma lalo o 1000 mau rubles i kēlā me kēia mahina.

Paki! Ma mua o ke kūʻai ʻana i nā lāʻau lapaʻau, pono e nīnau ʻia nā mea hoʻomaʻamaʻa hoʻomaʻamaʻa. Ma muli o ka noʻonoʻo ponoʻī ʻana hiki ke alakaʻi i nā hopena i hiki ʻole ke loaʻa ka hopena kālā koʻikoʻi. E kōkua ke kauka e kuhikuhi i ke hoʻoponopono kūpono a me ka pono, no laila ma ka hōʻailona mua e pono ai ʻoe e ʻimi i ke kōkua olakino.

ʻO ke kumukūʻai o ka lāʻau lapaʻau a me nā loiloi

Hiki ke kūʻai ʻia ka lāʻau Baeta ma kekahi lāʻau lapaʻau a waiho i kahi kauoha ma kahi lāʻau lapaʻau pūnaewele. Pono e hoʻomaopopo ʻia e kūʻai aku ana i ka lāʻau lapaʻau ma o ka lāʻau lā wale nō. Mai ka mea hana o kēia huahana ʻo Suetena, no laila ua kiʻekiʻe ke kumukūʻai.

No laila, ʻaʻole nā ​​kānaka maʻamau a pau me ka maʻi o ka maʻi maʻi hiki ke kūʻai i kēlā lāʻau lapaʻau. Kūlike ke kumukūʻai ma ke ʻano o ka hoʻokuʻu ʻana o nā kālā.

• 1,2 ml syringe pen - mai 4246 a 6398 rubles,
• 2.4 ml syringe pen - mai 5301 a 8430 mau rubles.

ʻO ka manawa nei i alakaʻi ʻia i ka noiʻi marketing, ka mea i mālama ʻia e nā poʻe maʻi i koho i ka lāʻau. E hōʻike ana i ka lāʻau lapaʻau ʻo Byeta, ʻo kāna mau loiloi e hōʻike nei i ka loaʻa ʻana o kēia hopena maikaʻi ʻole:

1. ʻO ka hoʻonāukiuki o nā io o nā nīnūna: nāwaliwali, ka huakaʻi a me ka ʻole o ka momona.
2. Hoʻololi i ka metabolism a me kaʻai: kaumaha kaumaha, dehydration ma muli o ka luaʻi.
3. ʻO kahi hanana koʻikoʻi nui ia o ka hopena anaphylactic.
4. Nā huehuei a me ke ala ʻana: ka piʻi ʻana o ka mīkini a me ka constipation, ka pancreatitis akene (i kekahi manawa).
5. ʻO nā loli i ka urination: impalired function renal, hoʻonui i ka pae creatinine, renal failed a i ʻole kona hoʻohui.
6. ʻO ke ʻano o ka ʻili o ke kino: alopecia (nāʻuhele o ka lauoho), hōʻeha, urticaria, angioedema, maculopapular rashes.

ʻO kaʻoiaʻiʻo, ʻo ka manaʻo maikaʻiʻole ke kumu kūʻai o nā laʻau, ʻo ia ke kumu no ka nui o nā mea maʻi me ka maʻi diabetes i kā lākou mau loiloi ma ka Pūnaewele. Akā, ʻoiai, ʻo ka lāʻau lapaʻau e hoʻēmi pono i ka pae o ka glucose i ke koko o ka mea maʻi a kōkua i ka hakakā nui ʻana.

Eia kekahi, ma muli o nā peculiarities o kona hopena therapeutic, ʻaʻole ia e hoʻokau i ka hōʻeha hypoglycemia.

Nā hiʻohiʻona o ka lāʻau

I ka hihia inā ʻaʻole hiki ke hoʻokele ʻia ka mea maʻi i kēlā mau pahuhopu a manaʻo paha ʻo ia i ka hopena maikaʻiʻole, hiki i ke kauka ke hele nei e loli i nā ʻano mālama lapaʻau. Ua hana kēia i ʻelua ala nui - ma ka hoʻololi ʻana i ke ʻano o ka lāʻau a i ʻole e haʻalele iā ia. I ka lua o ka hihia, pono e koho i nā lāʻau lapaʻau ʻenehana e loaʻa iā ia ka hopena therapeutic a ʻaʻole ʻinoʻino i ke kino maʻi maʻi.

E like me kēia, ʻaʻohe ʻano like o Baeta. ʻO nā AstraZeneca wale nō a me Bristol-Myers Squibb Co (BMS) mau hui i hoʻoulu i ka 100% analogues o kēia lāʻau lapaʻau (generics). ʻElua mau ʻano o nā lāʻau lapaʻau ma ka mākeke lāʻau o Lūkini, kahi like like i ko lākou hopena therapeutic. E pili ana kēia:

1. ʻO Victoza kahi lāʻau lapaʻau e like me Baeta, he mimetin mimetic. Hāʻawi ʻia ka lāʻau lapaʻau ma ke ʻano o nā ʻāpana syringe no nā infusion subcutaneous i ke ʻano maʻi type 2. ʻO ka hoʻohana mau ʻana i ka lāʻau lapaʻau e kōkua i ka hoʻemi ʻana i ka pae o ka hemoglobin glycated i 1,8% a nalowale i ka 4-5 kg ​​ka manawa o ka makahiki o ka ʻoihana. Pono e hoʻomaopopo he kauka kauka hiki i ke kūpono o ka lāʻau lapaʻau kūikawā. ʻO ka kumukūʻai maʻamau (2 peni syringe o 3 ml) he 10,300 mau rubles.
2. ʻO Januvia kahi mimetin mimetic e hoʻohaʻahaʻa i ke kōhi koko i ka mālama ʻana i ka maʻi maʻi 2. Loaʻa i nā palapala papa. ʻO ka kumukūʻai kūpono o kahi lāʻau lapaʻau (28 mau pūʻulu, 100 mg) ka 1672 rubles, ʻo ia ka mea haʻahaʻa loa i waena o nā lāʻau lapaʻau i nīnau ʻia. Akā ʻo ka nīnau a ka mea i hana e ʻoi aku ka maikaʻi ke lawe i nā mea i hiki i ka hoʻokūkū o ke kauka.

A pēlā nō, ʻo ka lāʻau lapaʻau Bayeta he mea waiwai e hoʻomaʻamaʻa hypoglycemic maikaʻi. Aia kona hopena therapeutic kekahi mau hiʻohiʻona e kōkua i ka hoʻokō piha i ka mana glycemic. Eia naʻe, ʻaʻole hiki ke hoʻohana ʻia ka lāʻau lapaʻau i kekahi mau mea a hiki ke hoʻohana ʻia i nā hopena maikaʻi ʻole.

No laila, ʻaʻole pono nā mālama pilikino. Pono e hoʻokō i kahi huakaʻi i ke kauka nāna i kuhikuhi akahi pono i ka hoʻohana ʻana i ka lāʻau lapaʻau, me ka mālama ʻana i nā hiʻohiʻona o ke kino o kēlā me kēia maʻi. Me nā kūpono kūpono a me ka hahai ʻana i nā lula a pau no ka hoʻopuka o ka hopena, hiki iā ʻoe ke hōʻemi i ke kō i nā pae maʻamau a haʻalele i nā hōʻailona o ka hyperglycemia. ʻO ke wikiō ma kēia ʻatikala e kamaʻilio e pili ana i nā lāʻau lapaʻau maʻi.

ʻO nā waiwai Pharmacological

ʻO Exenatide (Exendin-4) he agonist receptor e like me ka glucagon e like me ka amidopeptide 39-amino. ʻO ka mea nui, e like me ka peptide-like glucagon-1 (GLP-1), e hoʻonui i ka huna ʻana i ka glucose o ka glucose, e hoʻomaikaʻi i ka hana cell cell, e hōʻoki i ka hoʻonui ʻia ʻana o ka pale me ka hoʻokaʻawale i ka ʻōpū ma hope o kā lākou komo ʻana i ke kaila maʻamau mai nā ʻōpū. He exenatide kahi mimetic mimetin ikaika e hoʻonui ai i ka huna ʻana i ka glucose o ka glucose a loaʻa nā hopena hypoglycemic i loaʻa i ka incretins, e hoʻomaikaʻi ana i ka mana glycemic i nā mea maʻi me ka maʻi diabetes type 2.

ʻO ka mahele o ka waikawa amino o ka exenatide mahele like me ka pakanui o ka GLP-1, ma kahi o ia mea e hoʻopaʻa ai a e hana ai i nā mea hoʻokipa GLP-1 i loko o nā kānaka, e alakaʻi ana i ka synthesis e pili ana i ka glucose a me ka huna ʻana o ka insulin mai ka pancreatic beta cells me ka komo ʻana o ka cyPic AMP a me / a i ʻole nā ​​hōʻailona intracellular ʻē aʻe. ala. Hoʻokomo ʻo Exenatide i ka hoʻokuʻu ʻana o ka insulin mai nā beta beta i ka loaʻa ʻana o ka piʻiʻana o ka glucose. Hoʻolaha ka Exenatide i ka hana kemika a me nā hana farmacological mai ka insulin, derivatives sulfonylurea, D-phenylalanine derivatives a me meglitinides, biguanides, thiazolidinediones a me nā alpha-glucosidase inhibitors.

Hoʻonui ka Exenatide i ka mālama glycemic i nā mea maʻi me ka maʻi type 2 no ka mea hana i kēia mau hana.

Hoʻopili ʻia nā mea huna insulin. i nā kūlana hyperglycemic, hoʻomaikaʻi ka exenatide i ka huna ʻana i ka glucose i ka huna ʻana i nā insulin mai nā papa beta pancreatic. Ua kāpae kēia mea huna huna i ka hoʻōla ʻana o ka glucose i ke koko a ke hoʻokokoke nei ia i ka maʻamau, a laila e hōʻemi ʻia ka hopena o ka hypoglycemia.

ʻO ka mea mua o ka pane ʻana i ka insulin. ʻO ka neʻe ʻana o ka insulin i nā minuke 10 mua, i kapa ʻia ʻo ka "pae mua o ka pane ʻana i ka insulin", ua paʻa ia i nā mea maʻi me ka maʻi maʻi 2. Eia kekahi, ʻo ka nalowale o ka pae mua o ka pane ʻana o ka insulin he ʻemi o ke ʻano o ka hana ʻana o ka beta cell e hana i ka maʻi diabetes type 2. Hoʻomaka hou ka mālama ʻana o ka exenatide i ka mua a me ka lua o nā lua o ka pane ʻana i ka insulin i nā maʻi maʻi me ka maʻi type 2.

Hoʻokaʻa ʻia Glucagon: i nā mea maʻi me ka diabetes type type 2 e kū'ē ana i ke kua o ka hyperglycemia, ke hoʻomalu nei ka hana o ka exenatide i ka hōʻailona o ka ʻona. Eia nō naʻe, ʻaʻole e hoʻopili ʻo exenatide i ka pane o ka glucagon maʻamau i ka hypoglycemia.

Pā meaʻai ʻana: ka hoʻokele o ka exenatide alakaʻi i kahi hoʻohaʻahaʻa i ka momona a me ka hoʻohaʻahaʻa ʻana i ka ʻai o ka meaʻai.

Hokaʻa Gastric: hōʻike ʻia i ka hoʻomalu ʻana o ka exenatide i ka hoʻomoʻomaʻo o ka gastric, e hoʻohiolo ana i kona hakahaka. I nā maʻi me ka diabetes type mellitus type, exenatide therapy ma monotherapy a me ka hui pū me ka metformin a / a i ʻole ka hoʻomākaukau ʻana i ka sulfonylurea i ka hōʻemi ʻana i ka ʻaihue ʻaʻikukū o ka toto, ke kūpaʻa ana i ka pakano koko a postprandial, a me HbA1c, ma laila e hoʻomaikaʻi ai i ka mālama glycemic i kēia mau maʻi.

Lapaʻau lāʻau

Ma hope o ka hoʻomanawanui subcutaneous i nā maʻi me ka diabetes mellitus type 2, ua hele koke ka exenatide a hiki i ka hōʻea ʻana o ka plasma kiʻekiʻe ma hope o 2.1 mau hola. ʻO ka awelika kiʻekiʻe ka nui (Cmax) ka 211 pg / ml a me ka nui o ka wahi ma lalo o ka neʻe o ka paʻa-manawa (AUC_0-int) ka 1036 pg x h / ml ma hope o ka lawelawe ʻana o subcutaneous o kahi hapa o 10 μg exenatide. Ke kū nei i ka exenatide, hoʻonui nui ʻo AUC i ka nui o ka hoʻonui ʻana i ka hopena mai 5 μg a 10 μg, ʻoiai ʻaʻole i hoʻonui ka nui i ka Cmax. Hoʻomaʻamaʻa ka hopena like me ka hoʻokele subcutaneous o exenatide ma ka ʻōpū, ka ʻūhā a me nā poʻohiwi paha.

ʻO ka nui o ka hoʻoili ʻana o ka exenatide ma hope o ka hoʻolālā subcutaneous he 28.3 lita.

Metabolism a me ka hoʻopā ʻana

ʻO ka exenatide hana mua ʻia e ka filomation glomerular i ukali ʻia e ka proteolytic degradation. ʻO Exenatide clearance ʻo 9.1 l / h a me ka hapalua hope o ke ola he 2,4 hola. ʻO kēia mau hiʻohiʻona pharmacokinetic o exenatide he kūʻokoʻa kūʻokoʻa. Hoʻoholo ʻia nā mea hou o ka exenatide ma kahi o 10 mau hola ma hope o ka pau ʻana.

Nā hui ahonui kūikawā

ʻO ka maʻi me ka hana renal impaired

I nā mea maʻi me ka hana ʻole a pau ʻole lula paha (hana i hana ʻia me ka 30-80 ml / min), ʻaʻole i ʻokoʻa ka hoʻomaʻemaʻe ʻana o ka exenatide i nā mea i loko o nā kumuhana me ka hana maʻamau, no laila, ʻaʻole i koi ʻia ka hoʻoponopono ʻana o ka lāʻau. Eia naʻe, i nā mea maʻi me ka hopena o ka renal stage me ka hopena o ka dialysis, ua hōʻemi ʻia ka clearance hōʻemi i 0.9 l / h (hoʻohālikelike ʻia me 9.1 l / h i nā kumuhana olakino).

ʻO nā mea maʻi me ka hana pūlima hemahema

No ka mea ua hoʻopili ʻia ka exenatide e nā keiki, ua manaʻoʻiʻo ke ʻano hepatic impaired i hoʻololi ʻole i ka neʻe o ka exenatide i ke koko. ʻO nā elemakule ʻAʻole pili ka makahiki i ka maʻi pharmacokinetic o exenatide. No laila, ʻaʻole i koi ʻia ka poʻe maʻi ʻōpiopio e hoʻokō i ka hoʻoponopono hoʻoponopono ʻia.

E na keiki ʻAʻole aʻo ʻia nā pharmacokinetics o exenatide i nā keiki.

Nā ʻIpiopio (12 a 16 makahiki)

Ma kahi noiʻi pharmacokinetic i hana pū me nā mea maʻi me ka diabetes mellitus type 2 i nā makahiki 12 o 16 makahiki, ʻo ka hoʻokele o exenatide ma kahi paeʻai o 5 μg i ukali ʻia e nā ʻōmaka pharmacokinetic e like me nā mea i ʻike ʻia ma ka poʻe pākeke.

ʻAʻohe ʻanoʻokoʻa ʻē aʻe i waena o nā kāne a me nā wahine i loko o ka pharmacokinetics o exenatide. Kāhea ʻAʻole pili ka lāhui i ka pharmacokinetics o exenatide. ʻAʻole koi ʻia ka hoʻoponopono ʻana ma ke ʻano ʻōiwi.

ʻO nā maʻi maʻi maʻi

ʻAʻohe mea hoʻomaopopo ma waena o ka index mass body (BMI) a me exenatide pharmacokinetics. ʻAʻole koi ʻia ka hoʻoponopono ʻana ma kahi BMI.

MANUFACTURER

Baxter Pharmaceutical Solutions ELC, USA
927 South Pahu Kahukimaka, Bloomington, Indiana, 47403, USA
Baxter Pharmaceutical Solutions LLC, USA
927 South Pahu Kahukimaka, Bloomington, Indiana 47403, USA

ALOHA

1. Baxter Pharmaceutical Solutions ELC, USA 927 South Curry Pike, Bloomington, Indiana, 47403, USA Baxter Pharmaceutical Solutions LLC, USA 927 South Curry Pike, Bloomington, Indiana 47403, USA (ka hoʻopiha ʻana iā ʻoe).

2. Sharp Corporation, USA 7451 Keebler Way, Allentown, PA, 18106, USA Sharp Corporation, USA 7451 Keebler Way, Allentown, Pennsylvania, 18106, USA (hui kūloko i loko o kahi peni ʻoihana)

PAKAI (KĀHAI (KAUINA)

Enestia Belgium NV, Belgium
Kloknerstraat 1, Hamont-Ahel, B-3930,
Belgia Enestia Belz NV, Belgium
Klocknerstraat 1, Hamont-Achel, B-3930, Belgium

KA MOOLELO KUPUNA

AstraZeneca UK Limited, UK
Pūnaewele ʻo Silk Road, Mcclesfield, Cheshire, SK10 2NA, UK
AstraZeneca UK Limited, United Kingdom brSilk Road Business Park, Macclesfield, Cheshire, SK10 2NA, United Kingdom

ʻAna inoa, ka inoa o ka hui i ʻāpono ʻia e ka mea nāna i hoʻopaʻa ʻia a i ʻole nona ka palapala hoʻopaʻa inoa o ka lāʻau lapaʻau no ka hoʻohana ʻana i nā lāʻau lapaʻau e hōʻoia i nā koi mai ka mea kūʻai.

ʻO ka hui o AstraZeneca UK Limited, United Kingdom,
i Moscow a me AstraZeneca Pharmaceuticals LLC
125284 Moscow, st. Kauahi, 3, p 1

Baeta: nā ʻōkuhi no ka hoʻohana, nā kumu kūʻai, nā loiloi, nā analogues

ʻO kahi maʻi ʻo mellitus ka maʻi maʻi e hoʻololi nui i ke ola o kahi kanaka. Ma muli o ia mea, pono ʻoe e hahai i ka meaʻai paʻa a me ka hoʻomaʻamaʻa, akā e tupu ana ʻaʻole lawa kēia. I kēlā mau kūlana, aia ka pono no ke kōkua olakino. ʻO Baeta kahi lāʻau lapaʻau i hoʻolālā ʻia e hōʻoluʻolu i nā kiʻekiʻe o ka glucose koko.

Nā hopena hopena

E noʻonoʻo i nā hopena pili i hiki ke hele mai i ka wā e hoʻohana ai i ka lāʻau lapaʻau:

• ʻŌpala Gastrointestinal. Hoʻopilikia i nā mea ʻono, nā pilikia me nā kīwaha, puʻu nui, hū i loko o ka ʻōpū, ka puʻu kiʻekiʻe i loko o nā ʻōpū, pancreatitis.
• Hāpai. Inā ʻoe e hoʻohana i ka lāʻau lapaʻau ma ke ʻano o ka hui ʻana me ka insulin a i ka metformin, a laila hiki mai ka hypoglycemia.
• Pūnaehana pīhoihoi waena. Ke lō nei i nā manamana lima, manaʻo i ka nawaliwali a hoʻonui pākuʻi.
• Allhesic rashes ma ka pūnaewele injection. Hoʻopili i nā palahalaha a me ka nui.
• ʻO Renal hiki ʻole.

Inā ʻoe e hoʻohana i ka lāʻau lapaʻau no ka manawa lōʻihi, a laila hiki i ke ʻano o nā antibodies i hiki. ʻOi aku kēia hana i ka hana hou. Pono e haʻalele i ka lāʻau lapaʻau, pani iā ​​ia me kahi mea like ʻole, e hele aku nā antibodies.

ʻAʻohe o antidotes Baeta. Hoʻokomo ʻia ka hopena no ka hopena ʻaoʻao i nā hōʻailona.

Aia ke kumukūʻai ma ke kumu kīnā:

• No ka hoʻolālā o 1.2 ml e uku ai ʻo 3990 mau rubles.
• No ka hopena o ka 2,4 ml - 7890 rubles.

I loko o nā lāʻau lapaʻau ʻē aʻe, e piʻi ke kumukūʻai. No laila, no ka laʻana, ua loaʻa kahi hopena o 1.2 ml no ka 5590 rubles, a me 2.4 ml - 8570 rubles.

E noʻonoʻo i nā mea like o Bayeta:

• Avandamet. Loaʻa he mau mea laikini metformin a me rosiglitazone, e hoʻohui pū kekahi. Hāʻawi ka lāʻau lapaʻau i ka mālama ʻana i ke kiʻekiʻe o ka glucose i ka ʻōnaehana kao, hoʻonui i ka ʻike ʻana i nā peka beta pancreatic i ka insulin. Hiki ke kūʻai no ka 2400 rubles.
• Arfazetin. Loaʻa he hopena hypoglycemic āpau. Kōkua i ka hoʻemi ʻana i ka glucose i loko o ka ʻōnaehana kaila. Hiki ke hoʻohana ʻia no ke kākoʻo kākoʻo, akā ʻaʻole kūpono ia no ka mālama pono. Hoʻomaʻamaʻa ka lāʻau lapaʻau ʻaʻohe hopena hopena a ua ʻoi aku i nā mea hou aʻe i nā analog kekahi i ke kumukūʻai. Kūlā - 81 mau rubles.
• Bagometua. Hiki i nā mea waiwai pili glibenclamide a me ke metformin. Hoʻonui nā mahele o ka maʻi i ka insulin. Hoʻēmi i ka kolamu. Kōkua ka lāʻau lapaʻau i ka huna ʻana i ka insulin. Hiki ke kūʻai ʻia no 332 mau rubles.
• Betanase I ka hoʻomaʻamaʻa ʻia me kēia mākaʻi, mālama pono ka mālama ʻana i ke kūlana o ke koko. Hoʻokomo ʻia ka lāʻau lapaʻau ma ka wā hāpai a me ka lactation. ʻAʻole ʻae ʻia ia e inu i ka waiʻona a me nā lāʻau lapaʻau e loaʻa ana ka ethanol i ka wā mālama. ʻAʻole paʻakikī e loaʻa i loko o nā lāʻau kūʻai.
• Victoza. ʻO ka lāʻau lapaʻau maikaʻi loa a koʻikoʻi. Hoʻopili i nā mea ikaika liraglutide. Hoʻonui ka pilikia i ka huna ʻana i ka insulin, akā ʻaʻole ka glucagon. Hoʻemi ka Liraglutide i ka makemake o ka mea maʻi. Kūʻai ʻia ma ke ʻano o nā syringe. Kumukūʻai - 9500 rub.
• ʻO Glibenclamide. Aia i ka glibenclamide mea hana ikaika. Hoʻonui i ka hopena o ka insulin ma ka huki ʻana o ka honi ma waena o ka pūnaehana mākala. Loaʻa i ka lāʻau lapaʻau ka hopena haʻahaʻa o ka hoʻomohalaʻana i ka hypoglycemia. Hiki ke hoʻohanaʻia e like me ka hoʻokaʻawale i nā lāʻau lapaʻau. Kia kani no nā rubles 103.
• ʻO Glibomet. Nā hānona metformin. Hoʻopau i nā mea huna o ka insulin. Hiki iā ia ke hoʻopau me ka insulin. Hoʻonui ka lāʻau lapaʻau i ka pilina o nā insulin me nā mea pane, ʻaʻohe hopena o ka hoʻomohala ʻana i ka hypoglycemia. Kumukūʻai - 352 rub.
• ʻO ka Gliclazide. ʻO ka mea waiwai e gliclazide. Hāʻawi iā ʻoe e hoʻohālikelike i ka pae o ke kō i loko o ke kaikuawai. Hoʻemi i ka hopena o ka vomb thrombosis, kahi maikaʻi no ke olakino. Kumukana - 150 rubles.
• Metformin. Hoʻokomo i ka gluconeogenesis. ʻAʻole hoihoi ka lāʻau lapaʻau i ka mea huna o ka insulin, akā hoʻololi i kona kūloko. E ʻae i nā pūlehu o nā mākala e hoʻomaʻamaʻa i nā glucose. Kumukana - 231 rub.
• Hoavius. Loi sitagliptin. Hoʻohana ʻia no ka monotherapy a i ʻole ka hoʻohui ʻana i ka mālama ʻana. Hoʻonui i ka synthesis insulin, me ka hoʻonaninani ʻana i nā ʻāpana pancreatic iā ia. Kumukana - 1594 rubles.

He aha ke ala kūpono e hoʻopili ai mai kēia mau metekema āpau? Aia ia i ka helu ʻana o ka mea maʻi. ʻAʻole ʻae ʻia ia e hoʻololi i kekahi lāʻau i kekahi mea ʻē aʻe ma mua o kou iho, ma mua o ka hoʻohana ʻia he pono ke nīnau aku i kahi loea.

E noʻonoʻo i nā loiloi e waiho ai nā kānaka e pili ana i ka lāʻau lapaʻau Bayeta:

Ua kākau ʻo Galina (https://med-otzyv.ru/lekarstva/144-b/35082-baeta#scomments) ʻaʻole pono ke kolohe i ka lāʻau. Ua hoʻololi wale ka wahine i ka lāʻau lapaʻau, ma hope o ka hoʻihoʻi ʻana o kona ʻano maʻamau. Ua kākau ʻo ia ka mea nui e mālama i ka meaʻai.

Ke ʻōlelo nei ʻo Dmitry (https://med-otzyv.ru/lekarstva/144-b/35082-baeta#scomments) ua hoʻohana ʻo ia i ka lāʻau lapaʻau no hoʻokahi makahiki. Mālama ʻia ka Sugale i kahi papa maikaʻi, akā ʻo ka mea nui, e like me ke kāne, he emi ka nui o ke kino ma ka 28 kg. ʻO nā hopena maikaʻi, puka ia i ka nausea. Wahi a Dmitry, he lāʻau lapaʻau maikaʻi kēia.

Ke ʻōlelo aku nei ʻo Konstantin (https://med-otzyv.ru/lekarstva/144-b/35082-baeta#scomments) he maikaʻi ka lāʻau lapaʻau, akā naʻe, ʻae ʻia ka ʻae ʻana. Manaʻoʻo ia hiki iā ia ke loaʻa i ka analogue o ka lāʻau lapaʻau, ke loaʻa nei i nā ʻano papa papa.

Hōʻike nā hōʻike ʻaʻole i kōkua ka lāʻau lapaʻau i nā mea āpau. ʻO kekahi o kona pilikia nui ke ʻano o ka hoʻokuʻu ʻana. ʻAʻole kūpono kēia no nā maʻi āpau.

Baeta - kahi lāʻau lapaʻau e hiki ai iā ʻoe ke hoʻonohonoho pono i ke kiʻekiʻe o ka hilo i loko o ka ʻōnaehana kao. He mea kūpono loa ia, akā ma kekahi mau mea i kuhikuhi ʻia no ka manuahi ma nā haukapila. Inā hoʻolohe ʻoe i nā loiloi hoʻomanawanui, ua lōʻihi loa ka lāʻau lapaʻau mai ka lehulehu.

Mālama a hoʻohele paha: