Insulin aspart lua ʻelua

ʻO ka hoʻomākaukau hoʻohui insulin hoʻohui, kahi hoʻohui o ka insulin kanaka. ʻO kahi hoʻokuʻu iki o ka biphasic e pili ana i ka aspart insulin soluble (30%) a me nā crystals o ka insulin aspart protamine (70%). ʻO ka aspart Insulin i loaʻa e ka ʻenehana recombinant DNA e hoʻohana nei i kahi kānana o Saccharomyces cerevisiae, i ka molekōne o ka insulin, ka paʻapaʻa waikawa amino ma kahi o B28 i hoʻololi ʻia e ka acid aspartic.

Lapaʻau

Hoʻopili ka aspyp insulin insulin a me nā mea nānā aku o ka membela cytoplasmic o nā pūpū a hana i kahi mea hoʻohui ʻona o ka insulin e hoʻoikaika ana i nā hana intracellular, e komo pū ana synthesis o kekahi o nā kīʻaha koʻikoʻi (hexokinase, pyruvate kinase, glycogen synthetase). ʻO ka emi ʻana o ke kao o ka glucose i ka koko ma muli o ka hoʻonui ʻana i kāna kaʻi intracellular, hoʻonui i ka hoʻowalewale ʻana e nā ʻūluna a me nā kiko adipose, a me ka emi ʻana o ka hōʻemi o ka hana glucose i loko o ka ate. ʻO ia ka hana like me ke kūmole kanaka i ka kūlike molar. ʻO ka hoʻoneʻe ʻana o ka hinu waikawa amino ma ke kūlana B28 me ka waikawa aspartic e hōʻemi ana i ka ulu ʻana o nā molekala e hoʻokumu i ka hexamers i ka hapa wai o nā lāʻau lapaʻau, i ʻike ʻia i ka soluble insulin kanaka. I kēia hana, ua hoʻoneʻe ʻia ka aspart insulin mai ka momona subcutaneous ma mua o ka soluble insulin e noho ana i loko o ka bulaasiao kanaka kanaka. Hoʻokomo hou ka Insulin aspart protamine. Ma hope o ka hoʻomalu sc, ulu ka hopena ma hope o nā minuke 10-20, loa ka hopena ma hope o ka hola 1–4, ʻo ka lōʻihi o ka hana a hiki i 24 mau hola (e hilinaʻi ana i ka makeʻe, ka wahi o ka lawelawe ʻana, ka nui o ke kahe, ke ʻano o ke kino a me ka pae o ka hana kino).

I ka s / a i kahi maʻa o 0.2 U / kg kino kino T_max - 60 mau minuke Hoʻololi loa ka hoʻopaʻa ʻana i nā protein koko (0-9%). ʻO ka hoʻoliʻi ʻana o ka insulin serum e hoʻi i ka mua ma hope o nā hola 15-18.

ʻŌpū a me ka lactation

Hiki paha ke hoʻohana ʻia inā hiki ke loaʻa ka hopena kūpono o ka ʻoi ma ka hiki o ka maʻi o ka pēpē (ʻaʻole i mālama ʻia nā haʻawina kūpono ʻia. ʻAʻole i ʻike ʻia inā hiki i ka insulin aspart biphasic ke loaʻa kahi embryotoxic i ka wā i hoʻohana ʻia i ka wā hāpai a inā paha e pili pū ana i ka hiki ke hānau.

I ka wā o ka hoʻomaka ʻana o ka hāpai ʻana a i kēlā wā holoʻokoʻa, pono ia e nānā pono i ke ʻano o nā mea maʻi me ka maʻi mellitus a nānā i ka pae o ka glucose i loko o ke koko. Ka pono o ka insulin, ma ke ʻano he kānāwai, e ho'ēmi i ka trimester mua a hoʻonui pinepine i ka trimesters lua a me ke kolamu o ka hapai.

I ka wā hānau keiki a ma hope koke o lāua, hiki i ka nui o ka insulin ke hoʻemi nui a hoʻomāhuahua, akā hoʻi koke i ka pae ma mua o ka wā hapai.

ʻAʻole i ʻike ʻia a komo paha ka lāʻau i ka waiū umauma. I ka wā lactation, hiki i kahi pono e hoʻoponopono i ka dosis.

Insulin aspart biphasic: hopena hopena

ʻO ka edema a me ka hewa reignive (i ka wā i hoʻomaka ai ka mālama ʻia), nā kūloko kūloko kūloko (hyperemia, ʻāʻī, hōʻeha o ka ʻili ma ka wahi i ʻōlelo ʻia), ka maʻi kūloko kūloko nui a me ka puhaka, hōʻeha, hoʻonui kahe, ka hana gastrointestinal hana, paʻakikī ka hanu, ka tachycardia, ka hoʻemi ʻia o ke koko, angioedema edema), lipodystrophy ma ka wahi ʻōlelo.

Hoʻohui

Kūʻai ʻole ʻo ka laikini insulin ʻelua mau lāʻau i nā hopena o nā lāʻau lapaʻau ʻē aʻe. Hoʻonui ʻia ka hopena hypoglycemic e nā lāʻau hypoglycemic oral, sulfanilamides, MAO inhibitors (me ka furazolidone, procarbazine, selegiline), carbonic anhydrase inhibitors, ACE inhibitors, anabolic steroid (including stanozolol, oxandrolone, metroprotinol and tetroprotinol tetrostanes) , disopyramide, fibrates, fluoxetine, ketoconazole, mebendazole, theophylline, cyclophosphamide, fenfluramine, pyridoxine, quinidine, quinine, chloroquine, ethanol a me nā huaʻala e pili ana i ka ethanol. Hypoglycemic 'ole o ka hihia hoʻi glucocorticoids, glucagon, ulu hōmona, thyroid hormones, estrogens, progestogens (no ka hoʻohālike ku una ha contraceptives), thiazide diuretics, CCB, heparin, sulfinpyrazone, sympathomimetics (e like me epinephrine, salbutamol, terbutaline), isoniazid, phenothiazine nā mea loaʻa, danazol, tricyclics, diazoxide, morphine, nicotine, phenytoin.

Nā beta-blockers, clonidine, lithium salts, reserpine, salicylates, pentamidine - hiki iā lākou ke hoʻoikaika a hoʻonāwaliwali i ka hopena hypoglycemic o ka insulin.

ʻO Bartasic insulin aspart: Dosage a me ka hoʻokele

P / c, koke ma mua o ka ʻai, inā pono - koke koke ma hope o ka ʻai ʻana. Hoʻokomo ʻia ka hoʻonāukiuki ma ka ʻūhā a i ʻole ka pā o ka ʻōpū ʻāʻī, a i ʻole ke poʻohiwi a i ʻole ka ʻeke. Pono e hoʻololi i ka pūnaewele injection i loko o ke aniani anatomical (e pale ai i ka hoʻomohala ʻana o ka lipodystrophy). Pono ka wela o ka insulin i ka mahana ma waena o ka lumi.

Hoʻoholo ʻia ka hopena o ka insulin aspart biphasic e ke kauka i kēlā me kēia hihia, e pili ana i ka neʻe o ka glucose i ke koko. I ka awelika, ʻo ka lā helu i kēlā me kēia lā he 0.5-1 hale / kg koʻikoʻi o ke kino. Me ke kū'ē o ka insulin (no ka laʻana, i ka momona) e hoʻonui ʻia ka pono o ka lā maʻamau, a i loko o nā mea maʻi me ka hoʻonaʻauao endogenous ʻona.

ʻO nā mea mālama palekana

ʻAʻole pono e lawelawe ʻia ka aspart insulin lua i ʻelua. Hiki i kahi waiole ʻole a i ʻole ke kāpae ʻana i ka mālama ʻana (me ka nui o ka type 1 diabetes mellitus) hiki ke alakaʻi i ka hoʻomohala ʻana o ka hyperglycemia a i ʻole ketoacidosis maʻi maʻi. Ma ke ʻano he lula, hōʻike ka maʻi hyperglycemia iā ia iho, i mau hola a i ʻole mau lā (nā hōʻailona o ka hyperglycemia: nausea, ka luaʻi, ka ʻalike, ʻulaʻula a me ka maloʻo ʻana o ka ʻili, ka waha maloʻo, hoʻonui i ka hopena o ka urine, makewai a me ka nalowale o ka makemake, ka helehelena o kahi ʻano o ka acetone i loko o ka ea hanu). a inā ʻaʻole kūpono kūpono hiki iā ia ke make i ka make.

Ma hope o ka hoʻokolohua ʻana i ka momona o ka metabolism, no ka laʻana, me ka hoʻomehana ʻana o ka insulin, hiki i nā mea maʻi ke ʻike i nā ʻano maʻamau o ka poʻe o ka neʻe o ka hypoglycemia, kahi e ʻike ʻia ai ka poʻe maʻi. I ka maʻi me ka maʻi diabetes me ka hoʻokolohua metabolic maikaʻi, ʻo nā hopena hoʻopiʻi o ka maʻi maʻi i hoʻomohala ma hope a holomua hou. Ma kēia mea, pono ia e hana i nā hana i kuhikuhi e pili ana i ka kāohi ʻana o ka metabolic control, me ka mālama ʻana i ka pae o ka glucose i ke koko.

Pono e hoʻohana ʻia nā ʻāpana insulin lua i ka pili pono me ka ʻaina o ka meaʻai. He mea pono e noʻonoʻo i ka helu kiʻekiʻe o ka hoʻomakaʻana i ka hopena ma ka mālamaʻana i nā mea maʻi me nā maʻi concomitant a lawe ʻole i nā lāʻau lapaʻau e hoʻolōʻihi i ka hoʻohemo ʻana o ka meaʻai. Ke hele nei i nā maʻi concomitant, ka mea nui o ka ʻano maʻi o ka maʻi hopohopo, he nui ka ulu ʻana o ka insulin. ʻO ka hana a i ʻole ka lau a me ka hana nūia hiki ke alakaʻi i ka hōʻemi i nā koi o ka insulin. Hōʻalo i ka ʻai a i ʻole hana i hoʻolālā ʻia ke alakaʻi i ka hoʻomohala ʻana o ka hypoglycemia.

Me ka hoʻomohala ʻana o ka hypoglycemia a i ʻole hyperglycemia, he hiki ke emi ana i ka ʻike o ka nānā ʻana a me ka wikiwiki ka wikiwiki, hiki i ka pilikia ke keehi aku i ka kaʻa a hana paha me nā mīkini a me nā mīkini. Pono e kuhikuhi ʻia nā mea maʻi e hana i nā hana e pale ai i ka hoʻomohala ʻana o ka hypoglycemia a me ka hyperglycemia. He mea koʻikoʻi kēia no nā mea maʻi me ka ʻole a hōʻemi iki paha i nā hōʻailona o nā mea hana mua i ka hoʻomohala ʻana i ka hypoglycemia a i ʻole ka hōʻeha ʻana i nā manawa pinepine o ka hypoglycemia.

Nā inoa kūʻai

NovoMix 30 Penfill: ka hoʻokuʻuʻana no ka hoʻokele subutaneus o 100 PIECES / ml, Novo Nordisk (Denmark)

NovoMix 30 Kālepa: ka hoʻokuʻuʻana no ka hoʻokele subutaneus o 100 PIECES / ml, Novo Nordisk (Denmark)

NovoMix 50 Kuhiakau: ka hoʻokuʻuʻana no ka hoʻokele subutaneus o 100 PIECES / ml, Novo Nordisk (Denmark)

NovoMix 70 Kālepa: ka hoʻokuʻuʻana no ka hoʻokele subutaneus o 100 PIECES / ml, Novo Nordisk (Denmark)

Ka hana lāʻau lapaʻau

Hoʻopili ʻo ia me nā mea nānā aku o ka membone cytoplasmic o nā pā a hoʻāla i ka pūhui insulin-receptor e hoʻoikaika i nā hanana intracellular, e komo pū ana synthesis o kekahi o nā kīʻaha koʻikoʻi (hexokinase, pyruvate kinase, glycogen synthetase). ʻO ka emi ʻana o ke kao o ka glucose i ka koko ma muli o ka hoʻonui ʻana i kāna kaʻi intracellular, hoʻonui i ka hoʻowalewale ʻana e nā ʻūluna a me nā kiko adipose, a me ka emi ʻana o ka hōʻemi o ka hana glucose i loko o ka ate. ʻO ia ka hana like me ke kūmole kanaka i ka kūlike molar. ʻO ka hoʻoneʻe ʻana o ka hinu waikawa amino ma ke kūlana B28 me ka waikawa aspartic e hōʻemi ana i ka ulu ʻana o nā molekala e hoʻokumu i ka hexamers i ka hapa wai o nā lāʻau lapaʻau, i ʻike ʻia i ka soluble insulin kanaka. I kēia hana, ua hoʻoneʻe ʻia ka aspart insulin mai ka momona subcutaneous ma mua o ka soluble insulin e noho ana i loko o ka bulaasiao kanaka kanaka. Hoʻokomo hou ka Insulin aspart protamine. Ma hope o ka hoʻomalu sc, ulu ka hopena ma hope o nā minuke 10-20, loa ka hopena ma hope o ka hola 1–4, ʻo ka lōʻihi o ka hana a hiki i 24 mau hola (e hilinaʻi ana i ka makeʻe, ka wahi o ka lawelawe ʻana, ka nui o ke kahe, ke ʻano o ke kino a me ka pae o ka hana kino). I ka s / i kahi maʻi o 0.2 U / kg koʻikoʻi kino kino Tmax - 60 mau minuke Hoʻololi loa ka hoʻopaʻa ʻana i nā protein koko (0-9%). ʻO ka hoʻoliʻi ʻana o ka insulin serum e hoʻi i ka mua ma hope o nā hola 15-18.

ʻO ke ʻano o ka mea Insulin aspart biphasic

ʻO ka hoʻomākaukau hoʻohui insulin hoʻohui, kahi hoʻohui o ka insulin kanaka. ʻO kahi hoʻokuʻu iki o ka biphasic e pili ana i ka aspart insulin soluble (30%) a me nā crystals o ka insulin aspart protamine (70%). Insart aspart loaʻa i ka ʻenehana DNA recombinant e hoʻohana ana i ke aho ʻO ka lauhaʻi cerevisiae, ma ka molekule o ka insulin, ka peni o ka ʻaina amino ma kahi o ka B28 ua hoʻololi ʻia e ka aspartic acid.

Nā hopena maikaʻi o ka waiwai Insulin aspart biphasic

Ke keu

Nā Hoʻomaka hypoglycemia - ka 'anuō "ka pehu, ka palupalu o ka ʻili, nā hopohopo, keehi nui, ka hopohopo, nāwaliwali ʻole, nāwaliwali, ka hōʻeha ʻana, ka hopohopo, ka wīwī nui, ka pōloli, ka pōkole o ka nānā ʻana i ke poʻo, ka nausea, ka tachycardia, nā hoʻopihapiha, nā neurological maʻi. koma.

Lāʻau: hiki i ka mea maʻi ke pani i ka hypoglycemia liʻiliʻi ma o ka lawe ʻana i ka glucose, ke kō a me nā meaʻai momona paha i loko. Ma nā hihia koʻikoʻi - i / in 40% hopena dextrose, i / m, s / c - glucagon. Ma hope o ka loaʻa hou ʻana i ka ʻike, ʻike ʻia ka mea maʻi e ʻai i nā meaʻai momona a keu e pale ai i ka hoʻomohala ʻana o ka hypoglycemia.

ʻO ka mālama mea hoʻomehana insulin aspart biphasic

ʻAʻole hiki iā ʻoe ke komo iv. Hiki i kahi waiole ʻole a i ʻole ke kāpae ʻana i ka mālama ʻana (me ka nui o ka type 1 diabetes mellitus) hiki ke alakaʻi i ka hoʻomohala ʻana o ka hyperglycemia a i ʻole ketoacidosis maʻi maʻi. Ma ke ʻano he lula, hōʻike ka maʻi hyperglycemia iā ia iho, i mau hola a i ʻole mau lā (nā hōʻailona o ka hyperglycemia: nausea, ka luaʻi, ka ʻalike, ʻulaʻula a me ka maloʻo ʻana o ka ʻili, ka waha maloʻo, hoʻonui i ka hopena o ka urine, makewai a me ka nalowale o ka makemake, ka helehelena o kahi ʻano o ka acetone i loko o ka ea hanu). a inā ʻaʻole kūpono kūpono hiki iā ia ke make i ka make.

Pono e hoʻohana ʻia ka lāʻau lapaʻau i ka pili pono me ko ka meaʻai o ka meaʻai. He mea pono e noʻonoʻo i ka helu kiʻekiʻe o ka hoʻomakaʻana i ka hopena ma ka mālamaʻana i nā mea maʻi me nā maʻi concomitant a lawe ʻole i nā lāʻau lapaʻau e hoʻolōʻihi i ka hoʻohemo ʻana o ka meaʻai. Ke hele nei i nā maʻi concomitant, ka mea nui o ka ʻano maʻi o ka maʻi hopohopo, he nui ka ulu ʻana o ka insulin. ʻO ka hana a i ʻole ka lau a me ka hana nūia hiki ke alakaʻi i ka hōʻemi i nā koi o ka insulin. Hōʻalo i ka ʻai a i ʻole hana i hoʻolālā ʻia ke alakaʻi i ka hoʻomohala ʻana o ka hypoglycemia.

ʻO ka hoʻoneʻe ʻana o ka mea maʻi i kahi ʻano insulin a i ʻole ka hoʻomākaukau ʻana i ka insulin i kahi mea hana ʻē aʻe e pono e hana ma lalo o ka mākaʻi ʻana o nā lāʻau lapaʻau, ʻokoʻa paha ka hoʻoponopono ʻana. Inā pono, hiki ke hoʻoponopono ʻia nā lāʻau lapaʻau i ka manawa mua o ka lāʻau o ka lāʻau a i ʻole ma mua o nā hebedoma mua a i ʻole nā mahina o ka mālama ʻana. Hiki ke loli me ka loli i ka ʻai ʻana a me ka hoʻoikaika kino kino. Hiki i ka hoʻomaʻemaʻe koke ʻana ma hope o ka ʻai e hiki ke hoʻonui i kou pilikia o ka hypoglycemia.

ʻO ke kumu o ka hana

Hoʻomaopopo kēia lāʻau lapaʻau i nā ʻenehana insulin i loko o ka kiko adipose a me nā uaua kinipona. Hōʻemi ka pae o ka glucose i ke koko ma muli o ka ʻike pono i nā ʻili e hoʻopili pono i ka glucose, ʻoi aku ka maikaʻi o ka komo ʻana i nā loko, aʻo ka uku o kona neʻe i loko o ke ate, ma kahi ʻē aʻe, e hoʻolōʻihi ana. ʻO ke kaʻina o ka hoʻokaʻawale i nā momona i ke kino ke hoʻoikaika a hoʻoulu i ke ʻano o ka hana ʻana o ka protein.

Hoʻomaka ka hana a ka lāʻau lapaʻau ma 10-20 mau minuke, a ʻo kona ʻike nui loa i ke koko ka mea i ʻike ʻia ma hope o nā hola 1-3 (ʻo 2 kēia ka wikiwiki e hoʻohālikelike ʻia i ka hormone kanaka). Kuhi ʻia kēlā ʻano monocomponent ma lalo o ka inoa kalepa ʻo NovoRapid (ma waho aʻe o ia mea, aia kekahi ʻelua o ka ʻōhua insulin lua, kahi ʻokoʻa i kona ʻano).

ʻO ka insulin Biphasic

ʻO ka aspart insulin o ka aspart ka mea e pili like i nā hopena o ka lāʻau lapaʻau ma ke kino. ʻO ka ʻokoʻa ka loaʻa iā ia o ka insulin hana pōkole (ʻo ia hoʻi ka aspart) a me ka hormone medium-acting (protamine-insulin aspart). ʻO ka hoʻohālikelike o kēia mau insulins ma ka lāʻau lapaʻau e like me kēia: 30% he wikiwiki ka wikiwiki a ʻo ka 70% ka lōʻihi.

Hoʻomaka maoli ka hopena nui o ka lāʻau i ka manawa kūpono ma hope o ka hoʻokele ʻana (i loko o 10 mau minuke), a me 70% o ke koena o ka lāʻau lapaʻau ka hana ʻana i ka hoʻouka o ka insulin ma lalo o ka ʻili. Hāʻawi hou ia i ka hana maʻalahi a hana i ka awelika a hiki i 24 mau hola.

Aia kekahi pūlima kahi e hui pū ai ka insulin manuahi (aspart) a me nā hormone hana lōʻihi (degludec). ʻO kāna inoa kālepa aʻo ʻo Ryzodeg. Ke komo i kēia mea hana, e like me kēlā me ka like i nā insulin like ʻole, hiki ʻoe i ka subcutaneously maʻamau, hoʻololi i kēlā me kēia manawa no ka injections (i mea e pale ai i ka hoʻomohala ʻana o ka lipodystrophy). ʻO ka lōʻihi loa o ka lāʻau i ka lua o ka manawa a hiki i 2 a 3 mau lā.

Inā pono pinepine ka mea maʻi e kau i nā ʻano o ka hormone like, a laila paha ke ʻoi aku i mua o ka hoʻohana ʻana i ka lua o ka laʻana o insulin. Hoʻemi kēia i ka nui o nā injections a kōkua i ka mālama pono ʻana i ka glycemia. Akā hiki i ka endocrinologist ke koho i ka hopena kūpono e pili ana i nā hopena o nā noiʻi a me ka ʻike hōʻike hoʻoweliweli.

Loaʻa a me nā ponoʻole

ʻO ka neʻe i ka aspart Insulin (ka biphasic a me hoʻokahi-phase) he ʻokoʻa i ka insanie kanaka maʻamau. I kekahi kūlana, ua hoʻololi ʻia ka prine acid amino e ka aspartic acid (ʻike ʻia ʻo ka aspartate). Hoʻomaikaʻi wale kēia i nā waiwai o ka hormone a ʻaʻole i hoʻopilikia i kekahi me ke ahonui maikaʻi, ka hana a me ka allergenicity haʻahaʻa. Mahalo i kēia hoʻololi, hoʻomaka kēia lāʻau lapaʻau e hana wikiwiki ma mua o kāna mau kikowaena.

ʻO nā nāʻino like ʻole o ka lāʻau lapaʻau me kēia ʻano insulin, hiki nō ke hoʻomaopopo, ʻoiai ʻaʻole hiki ke ʻike, akā he mau hopena paha.

Hiki iā lākou ke hōʻike iā lākou iho ma ke ʻano o:

ka ʻōpū a me ka ʻeha ma ka wahi i hoʻolilo ʻia,
huialohaʻi,
ʻili ka ʻili
ka lau maloʻo,
he hopena kūlohelohe.

Nā Hoʻohui

ʻO nā hoʻohālikelike me ka hoʻohana o ka lāʻau lapaʻau ka intolerance o ke kanaka, ka pāpaʻi a me ke kōpaʻa koko (hypoglycemia). ʻAʻohe paʻa i nā loiloi e pili ana i ka hoʻohana ʻana o kēia insulin i ka wā hāpai a me ka lactation. Ua hōʻike ʻia nā hoʻokolohua holoholona preclinical ma nā dosis i ʻaʻole iʻoi aku ma mua o ka mea i ʻōlelo ʻia, ua pā ka lāʻau i ke kino ma ke ʻano like me ka insulin kanaka maʻamau.

I ka manawa like, i ka manawa a ʻoi aku ka nui o ka lawelawe manuahi ma mua o ka 4-8 mau manawa i nā holoholona, ʻike ʻia nā kuhi hewa i ka wā mua, ka hoʻomohala ʻana o ka malenations congenital i loko o nā keiki a me nā pilikia e pili ana i ka hopena o ka hāpai ʻana.

ʻAʻole ʻike ʻia inā komo kēia lāʻau i ka waiū umauma, no laila ʻaʻole ʻia he wahine no nā umauma umauma i ka wā e mālama ai. Inā pono ka mea maʻi e hoʻoluhi i ka insulin i ka wā hāpai, koho mau ka lāʻau lapaʻau mai kahi hoʻohālikelike o nā pōmaikaʻi o ka makuahine a me nā mea kūʻē no ka pēpē.

Ma ke ʻano he kānāwai, i ka hoʻomaka ʻana o ka wā hāpai, pono ka hoʻēmi ʻana i ka insulin, a i loko o ka lua a me ke kolu o ka trimester, he hana hou ʻia ka lāʻau lapaʻau. Me ka maʻi maʻi gestational, ʻaʻole hoʻohana ʻia kēia mea hana. I kekahi hihia, ʻaʻole he endocrinologist wale nō, akā he mea pūpikiʻo kahi obstetrician-gynecologist e kuhikuhi i kahi lāʻau lapaʻau like i ka wahine hāpai.

ʻO kēia ʻano hana o ka hormone i ka hapanui o nā maʻi he hoʻomanawanui maikaʻi loa nā mea maʻi, a ʻoi paha ka hopena o nā ʻaoʻao mai kona hoʻohana ʻana.

Nui ʻano lāʻau me nā inoa kālepa like ʻole e pili ana iā ʻoe e koho i ke kaha ʻoi loa o ka injection no kēlā me kēia maʻi maʻi pākahi. Ke mālama pono nei i kēia lāʻau lapaʻau, koʻikoʻi he hahai i ka regimen i ʻōlelo ʻia e ke kauka a ʻaʻole poina e pili ana i ka meaʻai, hoʻomaʻamaʻa a me ke ola kino.

E hoʻokuʻu i ke ʻano

Hoʻopaʻa d / a me 100 IU / ml 3 ml No. 5

Hoʻokumu ʻia ka ʻikepili ma ka ʻaoʻao āu e nānā nei no nā pahuhopu ʻike a ʻaʻole ia e hoʻolaha i ka lāʻau lapaʻau ponoʻī ma kekahi ʻano. Pono ka punaewele e hoʻomaʻamaʻa i nā limahana mālama olakino me nā ʻike hou e pili ana i kekahi mau lāʻau lapaʻau, e hoʻonui ai i ko lākou pae kiʻekiʻe. Ke hoʻohana nei i ka lāʻau "Insulin aspart lua-hāhā" me ka nele o ka hoʻolako ʻana i kamaʻilio kūkākūkā me kahi loea, a me kāna mau ʻōlelo aʻoaʻo e pili ana i ke ʻano o ka hoʻohana a me ke ʻano o kāu lāʻau i koho ʻia.

Insulin Aspart lua-papa

ʻO ka mākaukau hana i loaʻa ma kahi ʻenehana DNA kūikawā e hoʻohana ana i ka mana o Saccharomyces cerevisiae, ma kahi o ke kumu waikawa amino i hoʻololi ʻia me ka acid aspartic. Hiki i ka hoʻohana ʻana i kēia lāʻau lapaʻau ke uku no ka diabetes mellitus (DM), e hōʻemi i ka nui o nā hoʻopiʻi kūikawā o ka maʻi, a i ʻole i ka lōʻihi o ka hiki ʻana mai o ka poʻe me ka mōʻaukala.

Ka hoʻonohonoho ʻana a me ke ʻano o ka hoʻokuʻu ʻana

ʻO ka hana ikaika o ka lāʻau (insulin Aspart) kahi genetically hoʻololi kanaka i ka insulin o ka hana ultrashort. Loaʻa ka loea hypoglycemic ma ke ala ʻelua ʻelua (soluble insulin Aspart a me ka crystals protamine) no ka loea subcutaneous a intravenous. Hoʻohui i kahi o ka hana ikaika, ʻo ka hoʻonohonoho ʻana o ka lāʻau me ka mea hoʻohui. E ʻike i ka papa ma lalo no nā kikoʻī hou.

Sodium hydrogen phosphate dihydrate

Sodium hydroxide 2M

Ka waikawa hanu kahiki 2M

ʻO nā waiwai Pharmacological

Hoʻopili ka mea hana ikaika i ka mea lapaʻau me nā mea nānā aku o ka membi cytoplasmic o nā hua, e hana ana i kahi ʻano o ka mea i hoʻopaʻa ʻia i ka insulin, e hoʻoulu ana i ka hoʻohuʻina o ka nui o nā huina o ka nui. ʻO ka hopena o ka lāʻau lapaʻau ma muli o ka hoʻonui ʻana o ka hūa o ka glucose e nā kiko, a me kahi kaohi o ke glycogenic hana o ka ate.

Ke hoʻololi nei i ka waikawa amino ma ke kūlana B28 me ka acid aspartic e hoʻemi ana i ka hoʻonaninani o nā molekala e hana i ka hexamers i ka hapa hoʻomehana o ka lāʻau lapaʻau, i hoʻomaopopo ʻia i loko o ke ʻano kūlohelohe o ka hormone. No muli o kēia, ʻo ka hoʻopili ʻana o ka Insulin Aspart mai ka momona subcutaneous e hele wikiwiki ana ma mua o ke kanaka. Ma hope o ka pāpā ʻana i ka lāʻau, hoʻopau ka hopena o ka hypoglycemia i nā minuke 15-20, a hiki i kona nui loa ma hope o 1-3 mau hola, a ma hope o nā hola 5-6, e hoʻi ka hoʻoliʻi o ka glucose i kona kūlana mua.

Nā hōʻailona no ka hoʻohana ʻana

Kahi ʻia ka Insulin Aspart no ka maʻi decompensated. Ma ka maʻi type 2, e hoʻohana ʻia ka lāʻau lapaʻau inā ua pau ʻole a ʻāpana paha i ka mea maʻi i ka naʻau o nā mea hoʻomehana i ka insulin i ka poʻe hypoglycemic waha i ka wā o ka hui pū ʻana. Eia kekahi, ua hoʻolako ʻia ka huahana pharmacological e ka poʻe e, i ʻole ma kahi o ke ʻano o lalo o ka maʻi (diabetes), ʻike i nā kūlana pathological intercurrent.

Nā ʻōkuhi no ka hoʻohana

ʻO ke ʻano o ka hoʻohana ʻana i ka lāʻau lapaʻau ka subcutaneous injection. Ke papa ʻia nei ka ʻōlelo intramuscular. Ua hoʻokaʻawale ʻia nā infusions Insulin no nā hōʻike kūikawā. E pono ke hoʻolauna ʻia i ka lāʻau i loko o ka pā o ka ʻōpū, ka ʻūhā a me nā ʻeke paha. Hiki iā ʻoe ke hoʻohana i ka analogue o ka inika kanaka ma mua a ma hope o ka ʻaina. Hoʻomaulia ʻia ka hopena o ka lāʻau lapaʻau no kēlā me kēia maʻi.

Me ka hana ʻole o ka renal a i ʻole ka hana ʻūlū, pono i ka emi ʻana o ka hormone, ʻoiai me nā maʻi maʻi e hopohopo ai ka nui, e koi ai i ka hoʻoponopono ʻana o ka maʻi Insulin Aspart. ʻO ka intake o kēia lāʻau lapaʻau e pili pū me ka meaʻai, no laila he mea kūpono e ʻike i ke kiʻekiʻe kiʻekiʻe o ka hanana ʻana o ka hopena i nā maʻi e lawe ana i nā lāʻau lapaʻau e hoʻolōʻihi ana i ka kīnā ʻana o ka meaʻai. Ma hope o ka hoʻopiʻi ʻana i ka hoʻoneʻe o nā haʻalohola, hiki i nā mea maʻi ke ʻike i kā lākou mau maʻi maʻamau o ka hypoglycemia, koi i ka hoʻoponopono koke ʻana i kahi hopena o ka glucose a me ke kō i loko.

Nā ʻōlelo kikoʻī

I loko o nā ʻōkuhi no ka hoʻohana ʻana, hōʻike ʻia ka ʻaʻole lawa o ka dosage a i ʻole hōʻoki ʻia ka mālama ʻana o ka maʻi diabetes hiki ke alakaʻi i ka hyperglycemia, ketoacidosis. ʻO ka hoʻohana ʻana o Insulin Aspart i kekahi mau hihia e koi ai i ka nui o ka nui o nā injections o nā mea hoʻohana mua hypoglycemic i hoʻohana ʻia. I ka wā o ka mālama ʻana i ka maʻi maʻi me kēia lāʻau lapaʻau, pono e mālama ʻia i ka wā e alakaʻi ana i nā kaʻa a hana i nā hana ʻē aʻe e koi ai i ka hoʻonui ʻana o ka nānā a me ka wikiwiki o ka hopena psychomotor.

Hoʻohui nūhou

ʻAʻole paʻa nā Insulin Aspart i nā lāʻau lapaʻau ʻē aʻe. Hoʻonui ʻia ka hana o ka lāʻau lapaʻau e nā lāʻau kūlohelohe hypoglycemic oral, MAO inhibitors, ACE inhibitors, carbonic anhydrase, sulfonamides, anabolic steroid, tetracyclines, drug-piha drug. Nā maʻi hoʻohālikelike, nā diuretics thiazide, heparin, antidepressants tricyclic, morphine, nicotine pale i ka hopena hypoglycemic o ka pālua ʻelua. Ma lalo o ka hopena o nā salicylates a me ka reserpine, hiki ke nānā ʻia ka nui a me ka nāwaliwali o ka hana o ka lāʻau lapaʻau.

Nā hopena ʻaoʻao a me ka overdose

Ma ka hoʻoholo ʻana i nā loiloi, i ka hoʻomaka ʻana o ka mālama ʻana me ka lāʻau lapaʻau i ka nīnau ʻana, e hele pinepine ana kahi ʻae ʻana o ka hoʻokaʻawale ʻana, kahi kū ka hapa nui. ʻO ia paha ka hoʻomohala ʻana o nā maʻi kūloko kūloko ma ke ʻano o ka hyperemia, hoʻonāukiuki i ka ʻili o ka wahi i hoʻopaʻa ʻia, ʻāʻī, nui. I nā hanana pinepine, ʻike ʻia ka hopena o ka hopena: angioedema, hoʻohaʻahaʻa i ke koko, tachycardia, paʻakikī ka hanu. E kūʻē i ke kiʻi ʻana o ka nui o ka nui o ka inika o Insulin Aspart, hiki i kēia ke ʻano ke pili i kēia.

huahuʻi,
nahoa
leo koma
ʻālaʻi ka maʻi neur
hoʻonā wahaʻōlelo
manaʻo ʻino
hoʻōla o ka maʻi retinopathy maʻi,
hoʻonui hoʻonui ʻia.

Nā ʻōlelo a ke kūʻai a me ka waiho ʻana

ʻO 30 mau mahina mai ka lā o ka hana ʻana ka lāe o ke ola o ka huahana. Pono ka Insulin Aspart e pale ʻia mai ka ʻike nui loa i ka wela a me ka māmā. E mālama i ke ʻano o ka hoʻololi ʻana o ka hormone i ka pā wela o 2-8ºC. E kūʻai aku ʻia ka lāʻau lapaʻau e nā lāʻau lapaʻau ma o ka lāʻau lapaʻau.

I ka hiki ʻole o ka hoʻohana ʻana o ka hāneʻe lua ʻelua hakahaka ma muli o ka intolerance pilikino o kāna mau māhele a i ʻole ka hemahema no ka lāʻau ʻiniki, kuhikuhi nā kauka i nā lāʻau lapaʻau e like me Insulin Aspart. I kēia mau lā, ke hāʻawi ʻia nei ka mea kūʻai aku i kahi koho nui o nā mea lawelawe hypoglycemic, akā, ke koho nei i kēia a i kēlā lāʻau lapaʻau, mea e pono ai nā mea hana mai nā USA, Japan, a me Western Europe. I ka nui o nā hihia, ua kuhikuhi ʻia nā ʻōhua like ʻole:

NovoRapid Flexpen,
Novolog,
NovoRapid Penfill

Kumukuai no Insulin Aspart

ʻO ka awelika kumukūʻai o kahi lāʻau lapaʻau i nā lāʻau lapaʻau ma Moscow e like me 1700-1800 p. kēlā me kēia 3 ml o ka hoʻokele hypoglycemic. Manaʻo ia i ka loaʻa ʻana o ka maʻi diabetes me ka inika i hoʻololi ʻia me ka nui o nā kālā kālā, ʻaʻole ia e uku nui ʻia i nā waiwai ʻoihana pūnaewele, a ʻoi aku ka haʻahaʻa o ka lāʻau lapaʻau ma mua o ka mea i hōʻike ʻia i loko o nā lāʻau lapaʻau.

ʻO Olga, he 48 makahiki. Ua hoʻohana wau iā Insulin Aspart i koʻu ʻike ʻana i ka maʻi pāʻaiʻi maʻi he hoʻomaka wale kahi hana. Ua kuhikuhi ʻia ka lāʻau maʻamau o kēlā me kēia lā nā kauka. Ma muli o nā ʻōlelo i loaʻa, ua hoʻokomo wau i nā pūʻulu o 5 i mua o ka papa ʻaina. Mahalo i ka lāʻau lapaʻau, ua hiki iaʻu ke hoʻomaʻamaʻa i nā pae glucose i kahi manawa pōkole.

Andrey, he 50 mau makahiki. No 3 mau makahiki koʻu pilikia i ka maʻi decompensated. ʻO nā paleʻai, nā meaʻai, he ʻano hana hana ʻole i kōkua i ka hoʻohaʻahaʻa ʻana i ke kōpaʻa o ke kō i loko o ke koko, no laila pono wau e hoʻololi i ka hāpai ʻana i ka hormone. Ua ʻōlelo ke kauka me ka hoʻohana ʻana i ka Insulin Aspart. Hoʻokomo wau i 20 IU o ka lāʻau lapaʻau i kēlā me kēia lā no ka mahina, ma hope o ka hoʻomau ʻana ke ʻano.

ʻO Elena, 56 makahiki koʻu mau hoʻohana ʻana iā Insulin Aspart no hoʻokahi makahiki i kēia manawa a, pono wau e hoʻomaopopo, maikaʻi koʻu maikaʻi. Ma mua o kēia, ʻike wau i ka nāwaliwali mau ʻana, hōʻeha ʻana i ka ʻeha. I kēia manawa ua hoʻolaha wau i nā ʻāpana 14 o ka lāʻau i ke ao. I ka manawa like, ʻike pololei wau i nā loli o kaʻu nohona maʻamau, ma ke kumu kahi e hoʻoponopono ai i kēlā me kēia lā o ka lāʻau lapaʻau i kēlā me kēia lā.

E pili ana i ka lāʻau lapaʻau

Ua ʻōlelo ʻia e hōʻemi i ka ʻike ʻana o ka dextrose i ka plasma.

Hoʻomaka ka hoʻohaʻahaʻa ʻana i ka glucose ma ka hoʻomaikaʻi ʻana i kona kahe ʻana e ka nāu. Ke hoʻolōʻihi nei ka lāʻau lapaʻau i ka helu o ka hana gula i ka loko a hoʻomaikaʻi i ka hoʻomaʻamaʻa ʻana o nā nui.

Ua kuhikuhi ʻia kahi pākahi maʻi no ka poʻe maʻi me ka maʻi type 1.

Hāʻawi ʻia ka insulin aspartum biphasic no ka maʻi maʻamau o ka lā 2, inā he kū'ē i nā antidiabetic agents.

Kahi pōkole ka hana a hoʻokahi kikowaena hapa. Loaʻa ma 10-20 mau minuke ma hope o ka noi. Ka lōʻihi o ka hōʻike ʻana a hiki i 5 hola.

Hana-ʻelua hana - a hiki i kahi lā. Hoʻopilikia ka hopena therapeutic ma hope o 10 mau minuke, no ka mea, he kō o ka nui o ka hana pōkole a me ka lohi.

Nā hiʻohiʻona noi

Ua hoʻohālikelike ʻia ka Insulin Bifaxicum a me Aspart i nā mea maʻi ma lalo o 6 mau makahiki o ka makahiki. ʻAʻole i mālama ʻia nā haʻawina e pili ana i ka hopena o ka lāʻau lapaʻau ma ke kino o nā keiki. ʻAʻole ʻike nā kauka i ke ʻano o ka lāʻau lapaʻau i ke ʻano maʻamau o ke keiki.

Hāʻawi mākou i kahi haʻawina i ka poʻe heluhelu o kā mākou pūnaewele!

ʻO ka lawe ʻana i ka lāʻau lapaʻau i ka wā lactation ʻaʻole i pāpā ʻia. ʻAe ʻia ka hoʻohana inā he liʻiliʻi ʻole ka hopena o ka pēpē i ka pōmaikaʻi i ka makuahine.

I nā poʻe maʻi maʻi, he mea pono e hoʻoponopono i ke kūleʻa. ʻO nā loli e pili ana i nā makahiki i ke kino ke alakaʻi i ke olakino maikaʻi. Ma muli o ka hana ʻana o nā hana kūloko, ua pilikia ka ʻano o ka lāʻau lapaʻaka hypoglycemic.

Hoʻopili pū me nā lāʻau ʻē aʻe

ʻO nā lāʻau lapaʻau e hoʻohaʻahaʻa i ke kōpaʻa koko, kahi i lawe ʻia ma ke alo, e hoʻoikaika i ka hana o ka mea ikaika. ʻAʻole manaʻo ʻia nā lāʻau like ʻole. Hoʻokumu ka hypoglycemia, kahi kūlana i hōʻike ʻia e ka emi o ka glucose i lalo o nā kumu maʻamau.

ʻO nā mea anabolic anabolic, Ketoconazole, Pyridoxine a me nā lāʻau lapaʻau hou e pili ana i ka ethanol a me ka tetracyclines, i hoʻohana pū ʻia i kēia lāʻau lapaʻau hypoglycemic, e hana pū kekahi i ka hōʻemi i ka glucose koko.

ʻO nā contraceptives oral, heparin a me antidepressants i hoʻohana ʻia i ka mellitus maʻi diabetes e hōʻemi i nā hōʻailona o ke kolohe e hiki ke hōʻemi i ka hopena o ka lāʻau.