Pehea e hoʻohana ai i ka lāʻau lapaʻau Tebantin? > He hoʻomaʻemaʻe a me ke pale aku

ʻO ke ʻano nui o Tebantin - nā kāmele Coni-Snap: ka gelatin paʻakikī, ka pāpale brownish-brown, ke kino kino ke hilinaʻi ʻia o ka laʻala, nā kīwī i piha i ka keʻokeʻo a i ʻole ke aniani paha (10 mau pcs.

eʻauʻau o ka 100 mg: kapoʻu ʻāpana No. 3, ke kino keʻokeʻo,
300 mg lōkō: ka nui capsule No. 1, kukui melemele ke kino,
400 mg kaona: kapuni nui ʻokoʻa 0, ke kino melemele-ʻoni.

1 kiaʻi pahu:

mea waiwai: gabapentin - 100, 300 a i 400 mg,
nā mea kōkua: talc, lactose monohidate, magnesium stearate, pregelatinized starch,
ka uhi kapole: hao dye oxide ʻulaʻula (E172), ka wai hao waiho pōpoki (E172), ka titanium dioxide (E171), ka gelatin,
kino kapena: hao dye oxide ʻulaʻula (E172) a me ka wai hao ʻeleʻale kai melemele (E172) - no nā dosis he 300 a 400 mg, titanium dioxide (E171), gelatin.

Lapaʻau lāʻau

ʻO Gabapentin kahi mea lipophilic, ka pilina o ka mea e like me ke ʻano o ke kumu o ka gamma-aminobutyric acid neutrotransmitter (GABA). Ma ka manawa like, e like me ka kaina o ka hana, ka gabapentin ʻokoʻa mai kekahi mau lāʻau ʻē aʻe e launa pū ana me nā ʻĀpana GABA: ʻaʻole ia e hōʻike i nā waiwai GABA-ergic a ʻaʻole i pili i ka haunaele a me ka metabolism o GABA.

Wahi a nā haʻawina mua, hiki i ka gabapentin ke hoʻopili i ka subunit α2-δ o nā kaila calcium gated volt-a me ka pale ʻana i ka kahe o nā calcium calcium, ka mea e hana nui i ka wā e hiki mai ana o ka hopena neuropathic. ʻO ka hana o ka gabapentin i ka hana neuropathic ma muli o kēia mau hana:

hoʻonui mahuahua o GABA,
ka hōʻemi ʻana o ka make o ka glutamate-neurons,
ka pale ʻana i ka hoʻokuʻu ʻana o ka neurotransmitters o ka hui monoamine.

Ma nā kikowaena koʻikoʻi o nā maʻi, ʻaʻole hiki i ka gabapentin ke hoʻopaʻa i nā mea i hopu ʻia i nā lāʻau maʻamau a i ʻole nā mea hoʻokele (me nā mea hoʻokipa GABA._A a me GABA_I, N-methyl-D-aspartate, glycine, glutamate a benzodiazepine) paha. ʻAʻole i like kā carbonamazepine a me ka phenytoin, ʻaʻole hiki i kēia ʻano ke hana me ka hoʻokahe sodium i ka vitro.

Manaʻo kekahi o nā hōʻike vitro e pili pinepine i ka gabapentin i nā hopena o ka glutamate receptor agonist N-methyl-D-aspartate, akā he mea maoli kēia ʻano kumu no ka ʻike ʻana i ka 100 100mol, ʻaʻole hiki ke loaʻa i ka vivo.

Hiki i ka Gabapentin ke hōʻemi iki iki i ka hoʻokuʻu ʻana o ka neurotransmitters monoamine a hoʻololi i ka hana o nā enzymes glutamate synthetase a me GABA synthetase i vitro. Hōʻike nā hoʻokolohua ma nā lālau i ka hoʻonui ʻana o ka metabolism GABA i kekahi mau wahi o ka lolo, akā naʻe, ʻaʻole paʻa ka manaʻo o kēia mau hopena no ka hana anticonvulsant o gabapentin. I nā holoholona, hiki i kēia waiwai ke komo maʻalahi i ka lolo lolo a pale i nā huhū i kumu ʻia e nā ʻano genetic a i kumu ʻia e nā kemu (e komo pū me nā GABA synthesis) a i ʻole ka electroshock maximum.

Lapaʻau lāʻau

Hoʻopau wikiwiki ʻia ka lāʻau lapaʻau, a nānā ʻia ka wela plasma nui loa ma hope o 3 mau hola. Ma hope o ka hoʻomau ʻana i ka hoʻokele ʻana, no ka loaʻa ʻana o ka lōʻihi o ka ʻike, pono 1 mau hola ma mua o ke ʻano hoʻokahi. ʻO ka bioavailability piha o gabapentin i nā kapoti e pili ana i ka 60%. Me kahi piʻi o ka hapa o ka lāʻau, hōʻemi ka bioavailability o kēia mea.

ʻO ka hoʻohana like ʻana o Tebantin me ka meaʻai, ʻoi aku i nā meaʻai momona kiʻekiʻe, e hoʻonui nui ʻia C_max a AUC o gabapentin e like me 14% a i ka manawa like ʻaʻole i pili nui i ka pharmacokinetics o ka waiwai.

Ke lawe nei i kahi 300-4800 mg o ka gabapentin, nā kumukūʻai kiʻekiʻe o AUC a me C_max hoʻonui me ka hoʻonui ʻana i kahi wai. Ma nā hopena ʻaʻole iʻoi aku ma mua o 600 mg, ke neʻe nei ka laha mai ka laina o nā hōʻailona ʻelua he liʻiliʻi, a ma nā kiʻekiʻe kiʻekiʻe he nui ʻole ka piʻi.

Me ka hoʻokele waha hoʻokahi, ʻo ka plasma kaohi o ka lāʻau i nā keiki 4-12 mau makahiki ka like me ka poʻe maʻi maʻi. Ua loaʻa ka mea hoʻohālikelike o nā kākā kaulike ma hope o 1-2 mau lā a hoʻomau i ke ala o ka ʻoihana.

I ke kino o ke kanaka, ʻaʻole hoʻomaʻamaʻa ka gabapentin i ka hana. Eia kekahi, ʻaʻole i hiki i kēia mau mana ke hōʻeuʻeu i ka hoʻonaninani o ka maʻi oxidative me ka hana i hui pū ʻia, ka mea i komo i ka metabolism o nā lāʻau lapaʻau.

ʻAʻole hiki iā Gabapentin ke hiki ke nakinaki i nā protein plasma (heʻu iho i ka 3%), a ʻo kona puʻina māhele he 57.7 lita. ʻO ka ʻike o ke gabapentin i ka wai cerebrospinal he 20% o ka neʻe ʻana i ka plasma i ka kūlike. Hiki i kēia mea ke hoʻokaʻawale i ka pale koko-lolo a komo i ka waiū umauma.

ʻO ka meaʻokoʻa o Tebantine mai i ka plasma he pilina laina. ʻO ka pau ʻana o ka hapa-ola, ʻaʻole i hilinaʻi i ka waiū a hana mai 5 a 7 mau hola. ʻO ka hoʻomaʻemaʻe Plasma, hoʻomaʻemaʻe i ka hana, a me ka gabapentin excretion rate permanent e kūlike i ka clearance creatinine. Hoʻopili ʻia ʻo Gabapentin ma o nā keiki, a lawe ʻia hoʻi mai ka plasma i ka wā hemodialysis.

I nā poʻe maʻi maʻi a me nā mea maʻi me nā hana renal impaired, hoʻemi ʻia ka gabapentin clearance mai ka plasma. Me ka clearance creatinine e emi mai ma kahi o 30 ml / min, ʻo ka hapalua-ola e like me 52 hola. I ka mālamaʻana i nā mea maʻi me ka hana renal impaired a me nā mea ma ka hemodialysis, ʻōlelo ʻia ka hoʻoponopono hoʻoponopono ʻia.

Nā hōʻailona no ka hoʻohana ʻana

wahi e loaʻa ai nā kuʻuna epileptic ʻokoʻa me ka ʻole o ka hoʻolaha ʻana i ka lua o nā keiki i nā keiki he 12 a ʻoi aku ka nui o nā makahiki he 12 a me nā maʻi maʻi - monotherapy a i ʻole ka hoʻōla hou ʻana,
ʻāpana hopohopo epileptic me ka hoʻomohala lima (a ʻole i ʻole) i nā keiki 3-12 mau makahiki he nui - mālama hou ʻia,
nā maʻi neuropathic i nā maʻi pākeke ma mua o 18 mau makahiki he nui - ka hōʻoluʻolu a me ka mālama.

Nā Hoʻohui

ka mumū o ka pancreas (pancreatitis) ma ke ʻano maʻamau,
lactation (hana umauma),
nā keiki a hiki i nā makahiki 3 (ʻo nā ʻano hana a pau)
keiki keiki he 3-12 mau makahiki (monotherapy),
lactose intolerance, lactase deficiency, glucose-galactose malabsorption,
hypersensitivity e gabapentin a me nā mea kōkua o ka lāʻau.

Me ka makaʻala, pono ke kuhikuhi ʻia ka lāʻau i nā mea maʻi me ka hana ʻoi aku ka hopena o ka pilikia.

I ka wā hāpai ʻia, hoʻohana ʻia ʻo Tebantin inā pono nā mea i manaʻo ʻia i ka makuahine e ʻoi aku ka nui o ka hiki i ka maʻi paʻi.

ʻO nā mea haʻahaʻa i nā keiki i ʻoi aku he 12 a ʻoi aku a me nā pākeke

No nā keiki i ʻoi aku o 12 mau makahiki a ʻo nā mea maʻi maʻi, ʻo ka hopena antiepileptic e makemake nui ʻia e ka maʻi e hāhai ʻia e ka nui o ka nui o ka nui o 900-112 mg / lā, i kekahi mau lā ma hope o ka hoʻomaka ʻana o nā lā.

Kūlana ʻia nā lā i kēlā me kēia lā a me ke papa kuhikuhi palapala (A):

I ka lā: 300 mg - 1 manawa i kēlā lā, 1 kōlani 300 mg a i nā manawa 3 mau lā i ka lā, 1 kōpapa 100 mg,
I ka lā II: 600 mg - 2 mau manawa i ka lā, 1 mau kāpena 300 mg a i ʻole 3 mau lā i ka lā, 2 mau poloka 100 mg,
III lā: 900 mg - 3 mau lā i ka lā 1 kapsul 300 mg aiʻole 3 mau lā i ka lā no 3 mau kōneka 100 mg,
IV lā a oi aku: hiki ke hoʻonui ʻia i ka nui i ka 1200 mg, hoʻokaʻawale i nā inikua like ʻole i 3 mau ʻōhua (no ka laʻana, 3 mau manawa i ka lā, 1 mau pahu 400 mg).

Nā ka hoʻoponopono hou ʻana ma (B): ma ka lā 1 o ka hōʻola, ua lawe ʻia ka nui o ka hoʻomaka - 900 mg o ka gabapentin i kēlā lā i kēia lā, ka wā i hoʻokaʻawale ʻia ai he 3 mau pākana o 300 mg o 300 mg, i ka lā aʻe i hiki ke hoʻonui ʻia ka nui i 1200 mg i kēlā me kēia lā a ma waho (e pili ana i ka hilinaʻi. ka hopena hopena) hoʻonui i kēlā me kēia lā e 300-400 mg, akā ʻaʻole iʻoi aku ka nui o ka lā maʻamau o 2400 mg (me kahi intake ʻekolu manawa). ʻAʻole maopopo ka maikaʻi a me ka palekana o ka hoʻohana ʻana i nā ʻoina kiʻekiʻe o ka lāʻau lapaʻau.

ʻO nā mea hōʻeha hope i nā keiki 3-12 mau makahiki me ke koʻikoʻi o ke kino ma mua o 17 kg

Hoʻohana ʻia ʻo Tebantin i nā keiki mai 3 a 12 paha makahiki me ke koʻikoʻi o ke kino> 17 kg no ka lāʻau hou, no ka mea ʻaʻole lawa ka ʻikepili i ka palekana a me ka hana o kona hoʻohana ʻana i kēia ʻano makahiki he monotherapy.

ʻO ka laʻana i kēlā lā i kēia lā i ʻōlelo ʻia he 25-35 mg / kg a ua mahele ʻia i 3 mau pona.

ʻO ke kumuhana no ke koho ʻana i ka hopena kūpono e ka titration: lā 1 - 10 mg / kg / lā, lā 2 - 20 mg / kg / lā, lā 3 o - 30 mg / kg / lā. Inā pono, i ka wā e hiki mai ana, hiki ke hoʻonui ʻia ka nui o ka gabapentin i kēlā me kēia lā 35 mg / kg / lā, i hoʻokaʻawale ʻia i 3 mau pona. Wahi a nā haʻawina loiloi lōʻihi, ua hōʻoia ʻia ke hoʻomanawanui maikaʻi o nā iniha a hiki i 40-50 mg / kg / lā i hōʻoia ʻia.

I ka hoʻokau ʻana i nā dode ka hoʻomaka a hiki i nā kaila o ka gabapentin e hōʻea nei (i ʻōlelo ʻia i kēlā me kēia lā o ka gabapentin e pili ana i ke kaumaha o ke kino):

nā keiki kau paona 17-25 kg (600 mg i kēlā me kēia lā): lā 1 - 200 mg 1 manawa i ka lā, lā 2 - 200 mg 2 mau manawa i kahi lā, lā 3 - 200 mg 3 mau manawa i ka lā,
kaupaona nā keiki ma mua o 26 kg (900 mg i ka lā): lā 1 - 300 mg hoʻokahi i ka lā, 2 lā - 300 mg 2 mau manawa i kahi lā, lā 3 - 300 mg 3 mau lā i ka lā.

Kākoʻo i ka pona o Tebantin (ke kaumaha o ke keiki / ka momona): 17-25-25 -— 600 mg / lā, 26–36 kg –– 900 mg / lā, 37–50 kg -— 1200 mg / lā, 51-75 kg -— 1800 mg / lā.

ʻO ka maʻi Neuropathic

Ma ke ʻano o ka hōʻeha ʻana o ka maʻi neuropathic, ʻo ka hoʻoholo ʻia ʻana o ka hopena therapeutic e koho ʻia e ke kauka hele ʻana e ke ʻano o ka titration e pili ana i ka pane ʻana o kēlā me ka mea maʻi, ka hoʻomanawanui o ka lāʻau a me kāna hana pono. Hiki i ke ana ke piʻi i ka 3600 mg i kēlā me kēia lā (kiʻekiʻe).

Kūlana ʻia nā lā i kēlā me kēia lā a me ke papa kuhikuhi palapala (A):

I ka lā: 300 mg - 1 manawa i kēlā lā, 1 kōlani 300 mg a i nā manawa 3 mau lā i ka lā, 1 kōpapa 100 mg,
I ka lā II: 600 mg - 2 mau manawa i ka lā, 1 mau kāpena 300 mg a i ʻole 3 mau lā i ka lā, 2 mau poloka 100 mg,
III lā: 900 mg - 3 mau lā i kahi lā 1 capsule 300 mg aiʻole i 3 mau lā i kahi lā no 3 mau pūlama 100 mg.

ʻO kahi papa hana hou ʻia no ka mālama ʻana i ka ʻehaʻeha loa (B): ma ka lā 1, e hoʻomaka ana ka nui o kēlā me kēia lā he 900 mg o gabapentin (hoʻokaʻawale ʻia i 3 mau pona), a laila hiki ke hoʻonui ʻia ka ʻōloe ma luna o 7 mau lā a 1800 mg i ka lā.

No ka hoʻokō i ka hopena analgesic makemake ʻia, i kekahi mau mea, hiki ke hoʻonui ʻia i kēia make ke kiʻekiʻe o 3600 mg i kēlā me kēia lā, hoʻokaʻawale ʻia i 3 mau pālua. I ka hoʻomau ʻana i nā lāʻau lapaʻau e neʻe nei, ua hoʻonui ʻia ka nui o ka maʻi ma ka 1800 mg no ka wiki mua, a i ka 2400 a me 3600 mg, kekona, no ka lā 2 a me ka 3.

ʻO nā poʻe maʻi e palupalu, nā mea maʻi me ke kaumaha o ke kino a i ʻole ma hope o ka mālama ʻana i ke kino, ʻae ʻia ka nui o Tebantin e hoʻonui ikaika ʻia e 100 mg i kēlā me kēia lā.

I ka hana ʻole a pau me ka hana ʻana o creince (CC)

ʻO nā maʻi lāʻau lapaʻau o ka lāʻau Tebantin

ʻO Gabapentin kahi hōʻailona hoʻohālikelike o GABA. Mālama ka lipophilicity o ka molekopa gabapentin i kona komo ʻana ma o ka BBB. ʻAʻole maopopo ka ʻike maoli ʻana o ka hana. Hoʻopili ʻo Gabapentin i nā ʻōmole kōkua ma o nā ʻāpana sodium e hilinaʻi nei i ka mana a, ma muli o ia, e hoʻohālikelike i ka hana o nā pā kalima a me ke hoʻokuʻu ʻana o ka neurotransmitters. Hiki i nā ʻōnaehana i hana ma ke ʻano he gabapentin ke hōʻike ʻia ka hopena analgesic. Hoʻopili ʻo Gabapentin i ka hana o GABA synthetase a me ka synthetase glutamate i loko o vitro. ^ E Ha yM. Wahi a nā haʻawina, hoʻonui ʻia ka gabapentin i ka synthesis o GABA i ka lolo poloka. ʻAʻole hilinaʻi ʻia o ka hoʻopili ʻana i ka lāʻau i ka manawa o ka ʻai ʻana o ka meaʻai. I ka awelika, ʻo ka lōʻihi loa o ka gabapentin i ka plasma koko e hōʻea ma kahi o 3 mau hola ma hope o ka lawelawe waha hoʻokahi o Tebantin, ʻaʻohe o ka maʻi a me nā ʻōhua. ʻO ka manawa o ka hōʻea i ke kiʻekiʻe loa ma hope o nā hana pinepine o ka lāʻau lapaʻau ma kahi o 1 mau hola ma mua o ke kaha hoʻokahi.
Me nā hōʻano pinepine o ka lāʻau, ua hōʻea ke kūlana saturation ma hope o nā lā 1-2 a hoʻomau i ka holo nui o ka mālama ʻana.
Hāʻawi ʻia nā hua lāʻau pharmacokinetic o gabapentin (ka palena maʻamau i ka%) i ka hanana saturation ma muli o ke kaila i kēlā me kēia mau hola 8 e hāʻawi ʻia ma lalo nei.

400 mg (n = 11)

Cmax - kūwaha ka plasma wela,
Tmax - ka manawa e pono ai e hiki i Cmax,
T1 / 2 - hapalua-ke ola,
AUC (0 - ∞) - ka ʻāina ma lalo o ka neʻe a me ka pale o ka manawa.
ʻAe ka nui o ka gabapentin i hoʻopuka ʻia i loko o ka urine,
ND - ʻaʻole i hana ʻia ka ana.

ʻAʻole pili ke ʻano o nā bioavailability o gabapentin. Ma hope o ka hoʻāʻo (3 mau manawa i kahi lā) i nā kaʻe o 300-600 mg, ʻāpono ʻia no ka mālama ʻana, ʻo ia ka 60%.
I ka ate o ke kanaka, ʻaʻole pili ka gabapentin metabolism, ʻaʻole ka hopena o ka lāʻau i ka hoʻonoho ʻana o nā enzyme o ka ate i loko o nā kaʻina oxidative.
ʻAʻole paʻa ʻo Gabapentin i nā protein plasma a komo koke i ka BBB. ʻO ka ʻike ʻana i loko o ka wai o cerebrospinal he 20% o ka hoʻomohala ʻana i ka lolo o ke koko i ka hanana saturation.
ʻAi ʻia ka wehe ʻana o ka gabapentin mai ke kino ma o ke keiki i ka loli ʻole. ʻO ka hapalua o ka ola ʻo gabapentin T1 / 2 s nā hola 5-7. ʻO nā hōʻailona o ka haʻalele ʻana o ka gabapentin, T1 / 2, a me ka wehe ʻana o ka renal he kūʻokoʻa ʻole o ka hopena o ka lāʻau a ʻaʻole e loli ma hope o nā hana pinepine.
ʻO nā loli o ka makahiki i ka hana i ka poʻe maʻi, a me ka hana i ʻole ke ahonui i ka maʻi i hōʻike ʻia e ka poʻe maʻi, hōʻike ʻia i kahi hoʻohaʻahaʻa i ka hana ʻana i hana i ka creatinine, i alakaʻi ai i ka hoʻomaʻemaʻe ʻana o ka puna gabapentin a me ka hoʻonui nui ʻana i ka manawa o kona kinai ʻana. Ma ka hoʻohālikelike o ka hoʻohaʻahaʻa ʻana i ka cleance creatinine, ka emi mau o ka helu excretion o gabapentin, nā kāpena plasma a me ka wehe o nā renal clearance. No laila, e koho ʻia e koho i kahi maʻa o ka gabapentin e pili ana i ka cleince creatinine. Hiki ke huki ʻia nā Gabapentin mai ka lolo koko e nā hemodialysis.

Ka hoʻohana ʻana o ka lāʻau Tebantin

Hoʻomaʻamaʻa i ka ʻeha neuropathic i nā pākeke
Hāʻawi ʻia i ka hopena a me ka hoʻomanawanui o ka lāʻau lapaʻau, kau ke kauka i ke ʻano kūpono o ka therapeutic ma o ka hoʻonui pinepine ʻana. Ma muli o ka pane kūʻokoʻa o ka mea maʻi, hiki i ka palena kiʻekiʻe loa ke hiki aku i ka 3600 mg / lā.
Nā mea hoʻoponopono lula;

a) ma ka lā 1 - 300 mg o gabapentin (1 kōlani 300 mg 1 manawa i ka lā a i ʻole 1 capsule 100 mg 3 mau manawa i ka lā).
Ma ka lā 2 - 600 mg o gabapentin (1 kōlani 300 mg 2 mau manawa i ka lā a i ʻole 2 capsules 100 mg 3 mau manawa i ka lā).
Ma ka lā 3 - 900 mg o ka gabapentin (1 kōlani 300 mg 3 mau manawa i ka lā a i nā 3 capsules 100 mg 3 mau manawa i ka lā),
b) me ka ʻeha koʻikoʻi i ka lā 1, hiki iā ʻoe ke lawe i 1 kōlani 300 mg 3 mau manawa, kahi e hoʻohālikelike ai i ka 900 mg o gabapentin i kēlā me kēia lā. A laila, i loko o hoʻokahi pule, hiki ke hoʻonui ʻia i ka make i kēlā me kēia lā i 1800 mg.

I kekahi mau hihia, pono paha e koi ʻia kekahi nui e hoʻonui. ʻAʻole pono nā lā o kēlā me kēia lā e 3600 mg a pono e hoʻomāhele ʻia ma 3 mau pōneka. No nā mea maʻi me ka maʻi maʻamau, ma lalo o ke kaila o ka hoʻololi ʻana i ke kino, hiki ke hoʻonui ʻia ka nui o ka 100 mg wale.
I nā poʻe maʻi ʻelemakule, e like me ka kaila o ka makahiki i ka hana ʻana ma ka likinine clearance, nā mea maʻi me ka renal failed (creatinine clearance ≤80 ml / min) a me nā mea maʻi ma ka hemodialysis, pono ke koho pono ʻia ka pākēnē e like me ke kumuhana aʻe:
Hōʻike ʻia nā ʻāpana o ka gabapentin no ka hoʻohaʻahaʻa ʻana i ke koina

ʻO ka lā helu o ka gabapentin i kēlā me kēia lā, helu ʻia no 3 mau pākēneka i kēlā me kēia lā, mg / lā

* I kēlā me kēia mau lā 2, e lawe i ka 100 mg o ka lālani 3 mau manawa i ka lā (ʻo kēia pono ma muli o ka nalo ʻana o nā kapsul e loaʻa ana he 150 mg o gabapentin).

Nā papa kuhikuhi no ka hemodialysis: ʻO nā maʻi maʻi hemodialysis ʻaʻole i lawe i ka gabapentin i ʻōlelo mua ʻia e kuhikuhi i kahi dosis saturating o 300-400 mg, a laila kēlā me kēia hola 4 i kahi kime hemodialysis e kuhikuhi i ka 200-300 mg o ka lāʻau. I nā lā ʻaʻole i hoʻāʻo ʻia ka dialysis, ʻaʻole pono ka lawehala.
Lawe ʻia nā kapekoti Tebantin me ka hoʻā ʻole ʻole a inu i nā wai he nui. Hiki ke lawe ʻia nā Kapsules me nā papaʻai a ma waena o nā mea ʻai. Ke lawe nei i ka lāʻau lapaʻau he 3 mau manawa i ka lā, ʻaʻole pono ka haki ma waena o nā inikua ʻelua ma kahi o nā hola 12. Inā poina e ke ahonui e lawe i ka hopena hou aʻe o ka lāʻau, ua hoʻoholo ke kauka inā e hoʻohou hou.
Inā mālama ʻia ka nānā ʻana me nā antacids e loaʻa ana i ka alumini a me / a i ʻole ka magnesium i ka manawa like, pono e lawe ʻia aku nā kapika Tebantin ma mua o 2 mau hola ma hope o ka lawe ʻana i ka antacids i mea e pale ai i ka hoʻololi ʻia ʻana o ka bioavailability o gabapentin.
Aia nō ka lōʻihi o ka lāʻau lapaʻau ma luna o ka hopena hopena o ka hopena o ka maʻi, pono e mālama ʻia ka lōʻihi o ka mālama ʻana. ʻO ka hoʻopau ʻia ʻana o Tebantin a i ʻole ka hoʻololi ʻana i kekahi lāʻau lapaʻau antiepileptic e lawe mau pinepine ʻia, i ka liʻiliʻi no 1 wiki, no ka mea ʻole i hōʻike i kahi mea hoʻonui o ka waʻa epileptic.
Epilepia
ʻO ka maʻamau, ʻike ka hopena antiepileptic i ka wā e hoʻohana ʻia ka lāʻau lapaʻau i kēlā me kēia lā i nā lā 900-112 mg. ʻO ka makemake plasma therapeutic i makemake ʻia i ka lāʻau e hiki ke hoʻokō i loko o kekahi mau lā me ka hoʻohana ʻana i nā regimens dosis ma lalo.
Regimens lāʻau laʻana
a) ma ka lā 1 - 300 mg o gabapentin (1 kōlani 300 mg 1 manawa i ka lā a i ʻole 1 capsule 100 mg 3 mau manawa i ka lā).
Ma ka lā 2 - 600 mg o gabapentin (1 kōlani 300 mg 2 mau manawa i ka lā a i ʻole 2 capsules 100 mg 3 mau manawa i ka lā).
Ma ka lā 3 - 900 mg o ka gabapentin (1 kōlani 300 mg 3 mau manawa i ka lā a i ʻole 3 capsules 100 mg 3 mau manawa i ka lā).
Ma ka lā 4 - e hoʻonui i ka nui i ka 1200 mg, e lawe i 3 kahele i hoʻokaʻawale, ʻo ia hoʻi, 1 kapsul 400 mg 3 mau manawa i ka lā,
b) i ka lā 1, hiki iā ʻoe ke hoʻomaka me ka lawe ʻana i ka 1 capsule 300 mg 3 mau manawa, kahi mea e like me 900 mg o ka gabapentin i kēlā me kēia lā. A laila hiki ke hoʻonuiʻia i kēia lā i kēlā me kēia lā i 1200 mg.
Aia ma muli o ka hopena i loaʻa, hiki ke hoʻonui ʻia ke kaʻe i kēlā me kēia lā e 300-400 mg, ʻo ka pākahi lā i kēlā me kēia lā he 3 mauʻano ʻaʻole pono e hoʻonui i ka 2400 mg o gabapentin, ʻoiai i kēia manawa ʻaʻole nui ka ʻikepili i ka hopena a me ka palekana o ka hoʻohana ʻana i ka lāʻau lapaʻau i nā mea hou aʻe nāosa kiʻekiʻe.
ʻO ka mālama ʻia no nā keiki he 3-12 mau makahiki
ʻO ka ʻōpiopio i ʻōlelo ʻia i kēlā me kēia lā no 25 mau makahiki ʻo 25-35 mg / kg / lā, no nā keiki he 3 a me 4 mau makahiki - 40 mg / kg / lā. Ua mahele ʻia ka maʻi pākahi o kēlā me kēia lā i nā puʻupuʻu 3. Hāʻawi ʻia nā dosis no 1 kg o ke kaumaha o ke kino ma ka papa. Ua hoomakau- 1.
Papa Hana 1
Nā kahu mālama o ka gabapentin no nā keiki he 3-12 mau makahiki

ʻO ka huina o kēlā me kēia lā, mg

Hoʻoholo ʻia ka nui o ka hopena ma loko o nā lā 3 e like me kēia: ma ka lā 1, 10 mg o ka gabapentin e kuhikuhi i ka 1 kg o ke kaumaha o ke kino, ma ka 2 - 20 mg / kg / lā a ma ka lā 3 - 30 mg / kg / lā (papa. 2). Eia kekahi, inā pono, hiki ke hoʻonui ʻia i ka lā o ka lā i 35-40 mg / kg, e pili ana i ka makahiki. I nā haʻawina loiloi, hōʻoluʻolu ka mea maʻi i ka mālama lōʻihi i ka wā lōʻihi ma kahi o 40-50 mg / kg / lā.
Papaʻaʻina 2
Nā kinapo o ka gabapentin no nā keiki he 3-12 mau makahiki

Kau ka paona

ʻO ka huina o kēlā me kēia lā, mg

Kau ka paona

Nā hopena hopena o ka lāʻau Tebantin

Mai ka ʻaoʻao o ka pīkī laha waena: ka ʻeha, ʻeha, nā luhi a me ka lohi o ka neʻe ʻana o ka neʻe (ataxia), nystagmus, ʻike ʻole (diplopia, amblyopia), ʻeha, ka puʻuhū, ka ʻōpū maloʻo, dysarthria, amnesia, manaʻo ʻole i ke kaumaha, ʻehaʻeha, hopohopo, hana naʻau.
Mai ka palaki kuʻekuʻe: nausea, puaa, anorexia.
Mai ka pūnaehana cardiovascular: hoʻopiha.
Mai ke koko koko: leukopenia.
Mai ka ʻaoʻao o ka metabolism: peripheral edema.
Mai ka ʻōnaehana musculoskeletal: nā iwi i nā iwi, myalgia.
Mai ka papa hana hanu: huhū, pharyngitis, pōkole o ka hanu, rhinitis.
Ma ka ʻāpana o ka ʻili. huehae, ukuhi, luahi.
Mai ka pae genitourinary: huakai.
ʻO kekahi: ke kaupaona ʻana, ʻo ka asthenia, paresthesia, ka ʻōpū, ka ʻeha o ka ʻōpū a me hope, sensation ka wela.
I ka wā o ka mālama ʻana me ka gabapentin, hemorrhagic pancreatitis, kekahi mau ʻano o ke ʻano maʻi o ka maʻi (Stevens-Johnson syndrome, erythema multiforme) hiki mai.

ʻO nā ʻōlelo kūikawā no ka hoʻohana ʻana i ka lāʻau Tebantin

Ka maikaʻi ʻole ka lāʻau lapaʻau me nā hōʻeha mua, ma ka hoʻohālikelike. Me ka hoʻohana like pū me nā lāʻau antiepileptic ʻē aʻe, ua ʻike ʻia nā loli hepatic. ʻO ka lawe ʻana i ka lāʻau lapaʻau e pili ana i ka pae o ka glucose i ke koko (hyp- a hyperglycemia) paha. No laila, he mea pono e kāohi i kēia hōkuhi i nā mea maʻi me ka maʻi mellitus no ka hoʻoponopono hoʻoponopono ʻia o ka gabapentin i lawe ʻia.
I nā maʻi me ka hana renal impaired, gabapentin i kuhikuhi ʻia i loko o nā pora.
I ka wā o ka mālama ʻana, ʻike ʻia nā hōʻike maʻi o ka hemorrhagic pancreatitis. No laila, i ka wā e ʻike ʻia ana nā hōʻailona mua o ka pancreatitis maʻa (ʻeha hōʻeha i ka ʻōpū o ke kino, maʻi, ʻōpū, hoʻāʻo hou ʻia), ʻo Gabapentin e hoʻokuʻu. Pono e hoʻomaʻemaʻe pono ʻia ka mea maʻi (ʻo ka lāʻau a me nā hoʻokolohua hoʻokolohua) no ka hoʻomaka mua ʻana o ka maʻi pancreatitis maʻa. I kēia manawa, ʻaʻole lawa ka ʻike me ka hoʻohana ʻana o gabapentin i ka pancreatitis maʻi. I kēlā mau hihia, he nīnau no ke hoʻomau nei i ka ʻoihana gabapentin a i ʻole ke kāpae ʻia i hoʻoholo ʻia e ke kauka kauka.
Me ka intolerance lactose, pono e noʻonoʻo ʻia he 100 mg capsule e loaʻa ana he 22.14 mg o ka lactose, 300 mg - 66.43 mg, 400 mg - 88.56 mg.
ʻO ka lawe ʻana iā Tebantin i ka wā hapai he hiki ke kūpono wale nō ma hope o ka loiloi ʻana i ka ʻike o ka ʻona a loaʻa kālā no ka makuahine a me ke keiki.
Hele ʻo Gabapentin i loko o ka waiū umauma. Hoʻohana ʻia ka mālama ʻia me ka lāʻau lapaʻau i ka wā lactation ma muli o nā hopena koʻikoʻi koʻikoʻi i nā pēpē.
Hōʻalo ka hoʻokele a hana ʻana i nā hana e pili ana i ka nui o ka hōʻeha o ka hōʻeha, ʻo ia hoʻi i ka wā o ka wā mua o ka mālama ʻana, me ka piʻi ʻana o nā maʻi a me kahi hoʻololi i kekahi lāʻau lapaʻau antiepileptic.
Hiki i ka waiʻona ke hoʻonui i ka hōʻeha o nā hopena ʻaoʻao o ka gabapentin mai nā kikowaena kūloko o ka nui (no ka laʻana, he kumu ka hiamoe.
Me kahi hōʻike ʻehiku ʻehiku no ka huina o ka protein i loko o ka urine e hoʻohana ana i kahi kaula litmus, hiki i kahi hopena ke hoʻopunipuni. I ia mau kūlana, e aʻo ʻia e hōʻoia i ka hopena me ka hoʻohana ʻana i kekahi ʻano loiloi ʻē aʻe, no ka laʻana, e hoʻohana ana i kahi hōʻike Biuret (hōʻike ʻo Biuret) a i ʻole he ala turbidimetric.

Nā huahana lapaʻau Tebantin

ʻAʻole i loli nui ka nui o ka pae o ka phenytoin, carbamazepine, ka hopena valproic a me ka phenobarbital i ka paila koko, i hoʻohana ʻia ma ka lāʻau lapaʻau antiepileptic kumu i hui pū me gabapentin.
ʻAʻole pili ʻo Gabapentin i ka hana o ka norethindrone - a me / a me ethinyl estradiol-isacacacives, akā i ka wā e hui pū ʻia me nā lāʻau antiepileptic e hōʻemi ana i ko lākou hopena, pono e manaʻo ʻia ka hana ʻohiʻohi.
ʻO nā lāʻau lapaʻau e loaʻa ai ka alumini-neutralizing alumini a me ka magnesium hiki ke hōʻemi i ka bioavailability gabapentin e 24%. Pono e lawe ʻia nā lāʻau Tebantin ma mua o 2 mau hola ma hope o ka lawe ʻana i nā antacids.
Me ka hoʻohana like ʻana o gabapentin a me ka cimetidine, e pau ana i ka wehe ʻana o ka renal o ka gabapentin

ʻO ka overdose o ka lāʻau Tebantin, nā hōʻailona a me ka mālama

Mei hōʻike hōhā, diplopia, ke kaumaha, dysarthria, a me ka ʻeha. Hoʻomaka ʻia ka mālama maʻi Symptomatic. Hiki ke hoʻokaʻawale ʻia ʻo Gabapentin mai ke kino me ka hoʻohana ʻana i ka hemodialysis, ka hōʻailona no ka mea e pau ai ke ʻano o ka maʻi ma o ke ʻano maʻi o ka mea maʻi a i ʻole ka hoʻemi ʻana i ka hana hoʻohālikelike.

Nā hopena hopena

CNS (kaea ʻōkuhi o waena):

hiamoe,
āhāhuʻe,
nystagmus
ataxia
hoʻāliʻi ʻike i ka ʻike (amblyopia, diplopia),
hāpau
lie kanikela
hoʻokokoke,
haunaele o nā hana noʻonoʻo,
amnesia
manaʻo ʻino
hoʻoikaika naʻau
hopohopo o ke kaumaha
hoʻonui a hoʻonui ʻia huhū,
hoʻomaopopo maopopo
hoʻoheʻa
ho'ēmi i ka mālamalama
hyp- or areflexia,
hano a me hyperkinesis (ma nā mea maʻi ma lalo o 12 makahiki).

ka hoʻololi ʻana i ke koko (ma kekahi kuhikuhi)
hoʻopiha.

GIT (gastrointestinal tract):

ninini,
he ʻano hūnā
utuka,
hemorrhagic pancreatitis,
anorexia
nā ninia a i ʻoleconstipation
hoʻonui nui momona
gingivitis
maloʻo i ka waha
discoloration o ka niho enamel a i kona nalowale paha.

myalgia
nā iwi lahilahi lahilahi
aolaila.

erythema multiforme exudative,
Hōʻike ʻia ʻo Stevens-Johnson
fiva.

kuʻe o ka glucose i ke koko,
ua hoʻonui ʻia ka hana transaminase.

ka ʻōpū o ka maka
loaʻa ka paona
ʻeha ka ʻōpū
peripheral edema,
ʻeha ke kaumaha
ʻaiaiaia
fiva
purpura
nā hōʻailona ʻano ka pilala.

ʻO Tebantin, nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana (Ke ʻano a me ke ʻano)

Hāʻawi ʻia ʻo Tebantin no ka hoʻoponopono waha. Pulo ke papa o ka papa ʻaina, me ka ʻole o ka mea ʻai. ʻĀnō Gabapentin a ua hoʻoholo paʻa ʻia ka lōʻihi o ke aʻo ʻana e ka neʻe ʻana i kauka, e pili ana i ka palaka a me ke ʻano o ka maʻi. No nā maʻi maʻi epilepsy koho ʻia ka nui o ka lāʻau lapaʻau.

Hoʻomaopopo ʻia nā mea maʻi a me nā wā'ōpiopio ma mua o 12 mau makahiki i kahi mehana maʻamau i kēlā me kēia lā o 900-1200 mg. Hoʻoholo ʻia ka lāʻau mālama mālama i nā lā he nui e hoʻohana ana i ka hoʻolālā i hōʻike ʻia ma lalo iho nei: ka lā mua o ka papaʻi ʻana - ʻo ka lā o kēlā me kēia lā he 300 mg o ka ʻano ikaika ʻo Gabapentin (1 mau kōpapa o ka lāʻau Tebantin 300 mg). ʻO ka lā 2 o ka lāʻau lapaʻau - ʻo ka lā o kēlā me kēia lā he 600 mg (1 capsule o 300 mg a i ʻole 2 mau kīneka o 100 mg i ʻekolu mau puʻupuʻu i hoʻokaʻawale ʻia). ʻO ka lā 3 o ka lapaʻau - ka lālani o kēlā me kēia lā he 900 mg (1 capsule 300 mg ma ʻekolu mau ʻāpana ʻokoʻa. Mai ka lā 4 o ka papa maʻi, ʻo 900 mg (e hoʻonui paha i 1200 mg) o Gabapentin e kuhikuhi i ka lāʻau i kēlā me kēia lā.

Aia kekahi hoʻolālā kūpono no ke koho ʻana i kahi kū hoʻokahi o Tebantin, kahi lākou e ʻae ai i ka hana mua ʻana i kēlā me kēia lā o 900 mg (300 mg ʻekolu mau manawa i ka lā). Ma hope o ka hoʻomanawanui ʻana o ka ʻōlelo mua, hoʻonui ʻia i kēlā me kēia lā e ka 300-400 mg, a kāpae inā loaʻa ka hopena therapeutic makemake. Pēlā ka paia i loaʻa ai i ka ʻekolu i nā lā. ʻO ka lōʻihi loa o Tebantin i kēlā me kēia lā he 2400 mg ma nā huaʻōlelo o ka hana ikaika. ʻAʻole ʻikepili e pili ana i ka palekana a me ka hana pono o nā pawa heʻoi aku i ka nui o ka nui loa.

ʻO nā maʻi maʻi 5 a hiki i ka 12 mau makahiki e maʻi ana epilepsyNoea e hoʻomaka i ka hana maʻi me nā lā mua o kēlā me kēia lā o 10 mg / kg o ke paona, pālua ʻia (20 mg / kg) ma ka lā lua o ka mālama ʻana. I ke kolu o ka lā, piʻi ka nui ma ka 25-35 mg / kg a hoʻomau i kēia pae me ka hiki ke hoʻoponopono ʻia e ka neʻe ʻana i kauka e like me ka hopena i loaʻa. I epilepsy i nā keiki 3 - 4 mau makahiki i ʻōkena i kēlā me kēia lā Gabapentinkūlike me 40 mg / kg paona. Hoʻololi ʻia ka nui o ka hopena therapeutic ma mua o 3 mau lā, mai ka lawe ʻana i ka lā mua ma kēlā me kēia lā he 10 mg / kg i ka hopena makemake ʻia, e hoʻonui ʻia ana i ka hopena mua ma mua o ka ʻelua i ka lā 1. Pono ka kiʻekiʻe o nā lā ma mua no nā poʻe maʻi o kēia makahiki ʻaʻole kiʻekiʻe ma mua o 50 mg / kg o ke kaumaha o ke kino.

ʻO nā maʻi maʻi maʻi no ka hoʻomehana neuralgiama ke kānāwai, ua kauoha ʻia e mālama i kahi papa o ka mālama ʻana i nā lā i kēlā me kēia lā o ka 900-1800 mg. E like me nā hōʻike ʻana a me ka hoʻomanawanui maikaʻi o ka lāʻau lapaʻau, hiki ke hoʻonui ʻia ka nui o Tebantin i 3600 mg. Hoʻomaka ka lāʻau maʻi ma kahi o ka 300 mg i kēlā me kēia lā, me ka hoʻonui iki ʻana i ka nui o ka lāʻau i kēlā me kēia lā aʻe e 300 mg, a hiki i kahi lā he 900 o kēlā me kēia lā (3 mau lā). Inā maikaʻi ʻole ka nui o nā lā i kēlā me kēia lā he 900 mg, hiki ke pāpālua ʻia (a hiki i ka 1800 mg) no nā lā 7. Dosis Gabapentin, he nui i ka 300 mg i kēlā me kēia lā, ua hoʻokaʻawale ʻia i nā hapa he nui (ʻoi loa ma ʻekolu inikua). ʻO kahi papa hana hou aku e kuhikuhi ana i ka laʻana o kēlā me kēia lā o 900 mg hoʻokaʻawale ʻia i ʻekolu mau pona (3 mau pūlima o 300 mg pākahi).

I hemahema a me ka emi ʻole o nā contraindications (ma luna o 7 mau lā) e hoʻonui i ka lāʻau i ka 1800 mg. Hoʻohana pinepine ʻia kēia regimen lapaʻau no ka hōʻeha ʻeha. Nā ʻōkuhi no ka hoʻohana ʻana iā Tebantin 300 mg me neuralgia hōʻike i ka nui o ka lā maʻamau o 3600 mg. Pono e noʻonoʻo i ka maʻi maʻamau o ka mea maʻi, ke kaumaha haʻahaʻa, a ma hope iho helehelena ʻōnaehana, hiki ke hoʻonui ʻia i kēlā me kēia lā o ka lāʻau lapaʻau e ka hapa ma mua o 100 mg i kēlā me kēia lā. Oe e makemake i ka hoʻoponopono hoʻoponopono ʻana o ka lāʻau lapaʻau Tebantin, nā maʻi maʻi. Me nā pathologies kidney, ʻo ka pālua o kēlā me kēia lā Gabapentin, e like me ka lōʻihi o ke ʻano o ka mālama ʻana, ua hoʻoholo ʻia ma ke ʻano he kauka hele a kau i nā ʻōuli ʻO KK (hana ma kahi hana ma ml / min).

KK 80 a i luna - ʻaʻole iʻoi aku ma mua o 3600 mg,
KK 50-79 - ʻaʻole iʻoi aku ma mua o 1800 mg,
KK 30-49 - ʻaʻole iʻoi aku ma mua o 900 mg,
KK 15-29 - ʻaʻoleʻoi aku ma mua o 600 mg,
CC ma lalo o 15 - ʻaʻole iʻoi aku ma mua o 300 mg.

Ua hoʻokaʻawale ʻia ka ʻōlelo o kēlā me kēia lā i loko o ʻekolu mau manawa. Inā ʻaʻohe mea e pono i ka hoʻohana ʻana i ka nui loa, ʻo Tebantin i kuhikuhi he 100 mg ʻekolu mau manawa i ka lā a lawe i kēlā me kēia lā (300 mg i kēlā me kēia lā me kahi hoʻomaha o 24 mau hola). Ma kahi o ke kau i koho ʻia ai Gabapentinnā mea maʻi me CC mau mea ma lalo o 15 i lalo o ke kaʻina hana hemodialysis a ma mua ʻaʻole ka lawe ʻana i kēia lāʻau lapaʻau, tūtū i kahi pika saturating o ka lāʻau (300-400 mg).

Ma hope o kēlā me kēia hālāwai hemodialysiso nā hola 4, e lawe i ka 200-300 mg o ka lāʻau. I nā lā free hemodialysisʻAʻole i ʻae ʻia ʻo Tebantin. ʻO ka hoʻoneʻe ʻana o ka lāʻau Tebantin, ʻo ka hoʻokaʻina ʻana o ka mea maʻi i kekahi lāʻau lapaʻau ʻē aʻe hana antiepilepticlawe ʻia ia mau mea, ma muli o ka pilikia o ʻaihua epileptic.

Hoʻohui

Me ka hoʻohana pū ʻana o Tebantin me nā lāʻau antiepileptic ʻē aʻe (valproic acid, phenytoin, fenobarbital, carbamazepine) ʻaʻole i loli ko lākou nānā ʻana i ke koko. I ka manawa i koho ʻia ai me nā mea hoʻohālikelike waha ʻAʻole pili ʻo Gabapentin i ko lākou hopena, akā inā ka hoʻohana ʻana i nā lāʻau hoʻohui me nā lāʻau antiepileptic e hōʻemi ana i ka hopena o ka waha mea hoʻohālikelike, hiki ke hōʻemi ʻia i ko lākou hopena.

Ua pau ka make ʻana o ka renal Gabapentin i ka wā e lawe ʻia ai ʻO Cimetidine. ʻO nā lāʻau lapaʻau Antacid, nā mākaukau e loaʻa ana i ka magnesium a i ʻole alumini (acid-neutralizing) hiki ke hoʻopilikia i ka bioavailability o Gabapentin, e hōʻemi ana ia e ka 24%. Ma kēia mea, noi lākou i ka lawe ʻana iā Tebantin ma mua o 2 mau hola ma hope o ka noi antacids.

Hiki i nā hopena ʻaoʻao o Tebantin mai ke kikowaena kūloko pokela ke hoʻoikaika i nā mea ʻona e loaʻa ana i ka waiʻona, a me nā lāʻau lapaʻau e hoʻopili ʻia i ka pūnaehana neʻe. Hiki ke loaʻa he hopena maikaʻi-maikaʻi i nā hoʻokolohua laboratorium, me ke kōkua o kahi hōʻike litmus, i ka wā e noiʻi ana no ka huina o ka protein i loko o ka urine. Pono e ʻike ʻia nā ʻikepili mai kēlā me kēia noiʻi ʻana me ka hoʻohana ʻana i nā ʻōna noiʻi hou.

Hoike no Tebantin

ʻO nā loiloi e pili ana iā Tebantin ma nā pūʻulu, e like me ka lāʻau lapaʻau no ka mālama ʻana i ka hopu epilepsypaio loa. Pili kekahi kekahi i kēia lāʻau lapaʻau ma ka ʻaoʻao kūpono a hoʻomaopopo i ka emi ʻana o ka piʻi a me ka ikaika o ka hopu ʻana, ʻoiai ʻaʻole manaʻo nā poʻe ʻē aʻe i kekahi loli i ko lākou kūlana olakino. ʻO kēia paha ma muli o ke kuhi kūpono ʻana o ka lāʻau a me ke koho ʻana i ke kanaka kaukaʻi ʻia.

Nā loiloi hoʻomanawanui ʻeha kaho ʻana Ua ʻōlelo ʻia ʻo Tebantin he mea koʻikoʻi loa ia, e pili ana i nā ʻōlelo aʻo a ke kauka e komo ana. I waena o nā hopena hopena, ke kaulana pinepine nei ka ʻā. luhi a me ka hiamoe.

ʻO ka wehewehe, nā waiwai a me nā hiʻohiʻona

ʻO ka lāʻau Tebantin ua heluʻia he lāʻau lapaʻau anticonvulsant a me nā analgesic. ʻO ke kumu nui, ʻo ia ka hoʻomanū i ka lawepio a me nā mākeke ʻāpana ma ka pākeke a me nā keiki, me ka pale ʻana o kā lākou hōʻike. Eia kekahi, ua kuhikuhi ʻia ka lāʻau lapaʻau i nā mea maʻi me ka mamae neuropathy a me ka neuropathic pain syndrome e like me ka analgesic. ʻAʻole like me nā analogs a me nā mea i pani, e hāʻawi aku i nā kapaka i kahi helu liʻiliʻi o nā contraindications a ʻaʻole i hoʻokō ʻo ia i nā hopena ʻaoʻao hope, me ka hōʻoia pono.

ʻO ka mea nui o ka lāʻau ka gabapentin, i hana ʻia i loko o nā capsula gelatin o ka 100, 300 a me 400 milligrams. ʻO ka kinona kekahi o nā kaila kikoʻī o ka gamma-aminobutyric acid.

Hōʻike ʻo Gabapentin i ka hana analgesic a me ka hana antiepileptic, loaʻa nā hiʻohiʻona neuroprotective. Hoʻopuka maʻalahi nā molekuleka o ka pauku i ke kahe o ka lolo-lolo, ʻoiai he lipophilic.

ʻAʻole maopopo i ke ʻano o ka hana o ka gabapentin; aia kahi hōʻike o ka hoʻololi hou ʻana i ka hana o nā ʻāpana kalepoki a me ka hoʻokuʻu ʻana o nā neurotransmitters.

ʻO ka bioavailability o ka waiwai e piʻi a hiki i 60%, hiki i ka nui o ke koʻo i ʻekolu mau hola ma hope o ka noi ʻana o kahi laikini hoʻokahi. Loaʻa ka hoʻokalakupua i kahi hopena hoʻomehana holomua ma ka lua o ka lā a noho i ka wā mālama.

ʻO ka hapalua o ka ola o ka waiwai e pili ana i ka hola 5-6, ua lawe ʻia ka excretion ma waena o nā keiki. ʻO 20% o ka neʻe i ka plasma e nānā ʻia i ke kaila synovial.

ʻO ke kāpae ʻana i ka hapalua ola-nui i ka poʻe ʻelemakule, a me ka poʻe maʻi pūpū hoʻi e hōʻeha nei i ka renal a (a i ʻole) hōʻemi ʻia ka ate, hoʻonui.

Loaʻa ka lāʻau lapaʻau i ke ʻano o nā kapsul i kahi kinihula gelatin. Hoʻopili ʻia ke kīpē o ka lāʻau lapaʻau mai ka 50 a i 100 dosages, waiho ʻia ma ka waiho kaupaʻa ʻana. ʻO ka kumukūʻai kumukūʻai ma nā kaulahao lāʻau ma Rusia he 750-800 rubles. Mea hana - Gideon Richter OJSC. 1103, Budapest, Hanau.

Nā hōʻailona a me ke kumu nui

ʻO ke kumu nui o ka lāʻau lapaʻau e hōʻoluʻolu i nā hopu a me nā ʻeha o kahi ʻano neuropathic a me ka epileptic. I nā pākeke a me nā keiki, hoʻohana ʻia ʻo Tebantin no ka hoʻouka ʻana i ka epilepsy a me ka neuropathy penei:

No ka hoʻolalelale ʻana i nā ʻāpana ʻāpana me ka ʻole o ka hoʻonui ʻana i ka lua. Me he monotherapy a i ʻole ka hoʻopili i nā mea maʻi ma mua o 12 mau makahiki.
E pale aku i nā kahakaha mahele i nā mea maʻi me ka ʻole o ka hoʻomohala ʻana i ka lua o ka hoʻopiʻi ʻana i nā mea maʻi 3 a hiki i ka 12 mau makahiki.

No laila, ua kuhikuhi ʻia ka lāʻau lapaʻau e like me ka lāʻau nui a i ʻole e hoʻolauna ʻia i loko o ka hōʻiliʻili paʻakikī. ʻO ka hapa liʻiliʻi o ka mea maʻi e lilo i 3 mau makahiki. I ka pīhoihoi, ua maikaʻi ka lāʻau ma ke ʻano o ka lāʻau lapaʻau hou; ʻaʻole maopopo ka hopena o ka monotherapy.

Kūlana koho koho

Pono e paʻi pono nā papa i ka ʻole me ka ʻaʻa ʻole me ka wai liʻiliʻi. Hoʻoholo ʻia ka dosimen ke koho ʻia e nā ʻōkuʻi ʻana, makahiki a me ke kaumaha o ka mea maʻi. Ka heluʻana o ka paona maʻamau:

E hōʻoluʻolu i ka maʻi neuropathic, hoʻohana ka lāʻau hou i kēia:

i ka la mua: ʻekolu manawa o kēlā lā ma kahi o 100 mg capsule a i hoʻokahi dosis wale nō o ka 300 mg capsule,
kekona: ʻelua mau papa o 300 milligram a ʻekolu paha o nā iniki he ʻelua o 200 mg
o ke kolu,: ʻekolu kapena o 300 mg i ka lā.

ʻO kahi kumuhana hou (no ka maʻi ʻehaʻeha koʻikoʻi) pili i ka intake o kēlā me kēia lā o 900 milligrams o ka lāʻau lapaʻau, i hoʻokaʻawale ʻia i ʻekolu noi. ʻO ka palena loa loa ʻo 1800 mg i noi ʻia i hoʻokahi pule. ʻO kahi kūlana koʻikoʻi kahi hoʻonui hoʻonui nui i ka nui a me kahi hoʻohaʻahaʻa nui.

No ka hoʻokō ʻana i ka hopena therapeutic a me analgesic, hiki i ka hoʻonui iki ana i ka hoʻonui ʻia o 3600 milligrams ma ke kauoha o ke kauka hele mai. I kēia mau kūlana, ua māhelehele ʻia ka nui o kēlā me kēia lā i loko o nā noi he ʻekolu. Eia nō naʻe, nawaliwali nā mea maʻi ma hope o ka hōʻemi ʻana, a me ka poʻe i loaʻa ka pohō nui ʻana, ʻaʻole i ʻōlelo ʻia e lawe ʻia ma mua o 100 milligrams o Tebantin i kēlā me kēia lā.

ʻAʻole pili ka regimen i ka meaʻai i ka hoʻopili ʻana o nā ʻāpana o ka hui.

Koho ʻo ka helu ʻana i kēlā me kēia mea e like me ke kaupalena a me nā contraindications. No ka hōʻike, pono i kēia ala no ke kuapo ʻana a me ka maʻi hepatic a ma luna o nā makahiki o 50 mau makahiki. Hoʻohana ʻia ka ʻike hou ʻana ʻekolu mau manawa i ka lā.

Loaʻa paha nā ʻaoʻao maikaʻi maikaʻi

ʻO nā hopena hopena maikaʻi loa e kū pono i ke kikowaena waena a me nā ʻōnaehana cardiovascular. Hōʻike pinepine ʻia:

ke kaumaha a me nā malaise ākea,
kūleʻe a me ke kala ʻana,
hāpau
hoʻokokoke,
hoʻonui
hoʻopiha
kaomi koko,

Kēhea hiki i ka nānā aku i ka nānā ʻana i nā pilikia, nā pilikia o ke kūnaʻi o ka ʻōpala (flatulence, nausea a me ka luaʻi, ka hiki ʻana o ka ʻono, nā maʻi o ka maʻi, constipation, pancreatitis, waha maloʻo). ʻO nā hōʻike hōʻeha ʻē aʻe i nā hanana lohi:

aolaila
iwi ʻāhiu
leukopenia
pharyngitis, rhinitis,
ka pōkole o ka hanu a me ka ʻōpala
kani ana i na pepeiao
maʻi pākaʻi me ka hoʻonui ʻana i ka naʻau ma ka hana (hāwau o ka ʻili, ke kuni, ka erythema exudative),

Me nā hōʻike paʻakikī o nā hopena ʻokoʻa, hoʻonui ʻia i ke kaumaha a me ka malaise, ʻae ʻia ia e hoʻoponopono i ka dosage e like me ke ʻano kūʻokoʻa o ka mea maʻi. Me ka nui o ka nui o nā hewa i ʻōlelo ʻia e ka ʻōlelo, kahi hōʻike o ka malaise a me ka hiamoe, ke poʻomanaʻo, ka ʻōpū, ka hapanui o ka ʻike ʻelua. No ka hoʻonā i ka pilikia, hemodialysis, Hoʻohana ʻia ke ʻano maʻi. ʻAʻole loaʻa kahi ʻano antidote kūikawā iā Tebantin.

Nā hōʻike o ka lāʻau lapaʻau i nā lāʻau lapaʻau Lūkini

Inā kūpono, hiki iā ʻoe ke koho i ka analogues o ka lāʻau Tebantin e like me ke kumu hana nui, me ke ʻano o ka hona. Kuhi ʻia aku ka hapa nui o nā mea kūʻai ma waena o nā kaula lāʻau lapaʻau me ke ʻano kauka a ke kauka.

Tagu inoa	ʻO ke ʻano waiwai	Mea hana	Uka (rubles)
Pregabalin Richter	Pregabalin	Gideona Richter OJSC (Hungary), Gideona Richter-RUS CJSC (Rūsia)	350-400
Gabagamma	Gabapentin	Artesan Pharma (Kelemānia)	350-400
Lamictal	Nā Lamotrigine	Palapala GlaxoSmithKlein (Lūkia)	500-600
Keppra	Levetiracetam	UCB Pharma (Belgia)	800-900
Seisar	Nā Lamotrigine	Alkaloid AD (Repubalika Makedonia)	700-900
Wimpat	ʻO Lacosamide	UCB Pharma S.A. (Belgia)	1000-1200

Pono e koho ʻia nā nili a me nā mea e pili ana no ka hoʻomau ʻana i ka gabapentin, ʻaʻole lawa o Tebantin ʻoiai a i ʻole ka hopena o ka hopena maikaʻi ʻole ma hope o ka lawe ʻana i nā capsules. Koho ʻia ke koho e ke kauka haole e pili ana i nā ʻike a me nā hiʻohiʻona pilikino o ka mea maʻi. ʻAʻole hoʻohana ʻia nā lāʻau āpau ma ka maʻi pediatrics.

Nui ia ke hoʻohana ʻana iā Tebantin

Hoʻopili maikaʻi ʻo Tebantin a pale i nā kīwaha, nā ʻehaʻeha i ka epilepsy a me ka neuropathy i nā pākeke a me nā keiki me ka hoʻohana ʻana i kahi ʻōnaehana. ʻO ka maikaʻi o ka lāʻau lapaʻau he helu liʻiliʻi o nā contraindications me ke kiʻekiʻe kiʻekiʻe e hoʻohālikelike i nā analogues a me nā mea i hoʻokau. ʻO ke koho ʻana i nā dosages hiki ke lilo i kahi hana paʻakikī, e hilinaʻi ana i kēlā me kēia ʻano o ka mea maʻi, ʻo ia a me ke kaumaha o ke kino. He mea pono hoʻi e noʻonoʻo i nā pilikia o ka mālama ʻana i ka maʻi pediatrics.

He aha ka tebantine

ʻO ka mea hana mai ke kaʻi ʻana o ka lāʻau lapaʻau ka mea e like me ka γ-aminobutyric acid (GABA), kahi i ʻike ʻia he neurotransmitter me nā mea pale. ʻO ka pahuhopu mua o nā mea hoʻomohala gabapentin e hoʻihoʻi i ka hana hoʻohālikelike o GABA. Akā inā me ke kumu ua huli ʻia, a laila me ka ʻano o ka hana, ʻaʻohe mea. Hoʻopilikia pololei ʻo GABA i nā wahi o ka lolo. A pehea ʻo ka gabapentin e hōʻoluʻolu ai i ka ʻeha ʻaʻole ʻike maoli ʻia. Wahi a kekahi ʻaoʻao, ke pale nei i ka calcium ma ke komo ʻana i nā sela cortical, a e like me kekahi, ua pale ʻia ke ʻano o nā synapses hou. Eia kekahi, e hōʻeha i ka make i ka make neuronal a kōkua i ka hana hoʻoneʻe nui o GABA.

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He aha ka mea e kōkua ai

ʻO nā ʻōmaʻomanaʻo nui no Tebantin he mau maʻi neuropathic a me ka epilepsy e hoʻoulu ʻia i wahi i hoʻokahi ʻāpana o ka lolo. ʻAʻole hoʻohana ʻia kahi ʻano inā ke hoʻomohala nui ʻia nā mea pōkele, me ka nui o nā mākaha mānoanoa, nalowale o ka ʻike. No laila, ʻaʻole hiki ʻole nā palena malalo o ke noi:

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ʻO nā pahu koloi kūloko i nā maʻi o nā makahiki he 12.
ʻO ka hoʻomaʻikaʻi hou ʻana me ka maʻi like ʻole i nā pākeke.
ʻO ka Therapy o nā ʻano epilepsy, hōʻike ʻia e ka hōʻeha kūikawā a me ka pale ʻole o nā keiki i nā keiki mai 3 mau makahiki.

E like me nā hōʻeha neuropathic e kū mai ana i nā kaʻina hana kūlohelohe i nā ʻeha hōʻeha, ʻike pinepine ʻia lākou e ka mea hoʻonaninani, nā maʻi AIDS, nā maʻi maʻi, nā mea maʻi e hōʻeha nei i ka shingles a i ʻole ka stenosis o ka kanawai o ka spinal. Akā ke hoʻokuʻu iā lākou me Tebantin e ʻae ʻia i nā maʻi no nā makahiki 18 wale nō.

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Hiki i nā gynecologists ke kuhikuhi i ka lāʻau lapaʻau i nā wahine me nā menopause koʻikoʻi, ʻoiai inā he contraindicated ʻoi ke ʻano maʻi o ka hormone. Ma lalo o ka mana o gabapentin, e hoʻomaʻamaʻa ka hiamoe, a lilo ka ʻū wela wela, a hoʻomaikaʻi maikaʻi ke olakino.

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Nā ʻōkuhi no ka hoʻohana

Nā papa inoa o Tebantin i nā papa me 300 mg o ka mea hana ikaika. Ua piha lākou me nā sodium carboxymethyl starch, magnesium stearate a me ka microcrystalline cellulose. Hāpai ʻia nā capsules me kahi pūlehu gelatin i hoʻopaʻa ʻia me ka hao a me nā ʻāpana Titanium. Ua inu lākou ma mua a ma hope o ka ʻai, holoi ʻia me ka wai. ʻAʻole koke ka hopena o ka lāʻau lapaʻau, pono ʻoe e kali ma kahi o 2-3 mau hola.

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E hoʻoholo ke kauka i ka regimen lapaʻau a me ka dosis. Aia paha penei:

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No nā keiki mai ka 6 a hiki i ka 12 mau makahiki, e lawe ʻia ke kaupaʻa e like me ke kumu mua o 10-15 mg / kg o ke kaumaha me ka hoʻonui a hiki i ka 25-35 mg i nā lā ʻekolu. Ua māhele ʻia ka nui o ka lā i kēlā me kēia lā i 3 pōkē. ʻO ka palena ma waena o lākou ma kahi o 12 mau hola.
ʻO nā ʻōpio a me nā wāʻōpiopio ka inu i 3 kaila i ka lā, akā pono ʻoe e hoʻomaka me kekahi a hoʻonui e hoʻonui.

I kekahi manawa me ka ʻeha koʻikoʻi ʻoi aku ʻoe e lawe i ka 12 mau kōpona i kēlā me kēia lā, akā ke hoʻomau nei ka hoʻomaka ʻana o ka mālama ʻana.

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ʻAʻole ka hopena o ka mea ola me nā protein plasma a, ma hope o nā hola 6-7, ʻike ʻia i loko o ka urine. I ka poʻe maʻi me nā pilikia urological, lohi ka lāʻau. Pono lākou i ka mālama kūikawā a mālama pono hoʻi i ke koho ʻana i nā dosages.

ʻO ka hopena o ka lapaʻau he like ia me ka hoʻomaka, ka wā aʻe i luna o nā hebedoma a i mau mahina paha. Me ka hōʻole ʻana i ka Tebantin a me nā lāʻau lapaʻau antiepileptic maikaʻi loa, e hoʻonui ʻia ka hōʻeuʻeu o nā kiki. E ʻike pū ʻia me lākou:

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ʻano hana like ʻole
haehae maʻi
tachycardia
lie kanikela
ka momona loa
hopohopo
hilahila
ʻōpala
photophobia.

ʻO kēlā me kēia hoʻololi i nā loiloi e noʻonoʻo ʻia a lohi.

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I ka wā hāpai, hōʻike ke kauka i ka laha o nā hōʻemi a me nā pono o ka lāʻau lapaʻau. I nā holoholona laboratory, hōʻike i ka lāʻau lapaʻau i kona mauʻawaʻawa i ka ʻōpiopio. ʻAʻole paʻa i ka hopena kūpono i ka poʻe.

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I nā ʻōlelo haʻawina no ka hoʻohana ʻana iā Tebantin 300 mg, ua hoʻomaopopo ʻia aia ka mea hana i loko o ka waiū o ka waiū, akā ʻaʻole i aʻo ʻia he mau hopena e hopena ai kēia no ka pēpē. Inā pono e lawe i kahi anticonvulsant, pono ke hoʻopau ʻia ka lactation.

Kumukūʻai Tebantin

ʻAʻole pili wale ke kumukūʻai i ka hoʻopili ʻana o ka lāʻau lapaʻau, akā i ka lāʻau lapaʻau. Hiki ke kūʻai ʻia kahi pā o 50 mau papa o ka hana ʻana ma Lūkia no 400 rubles, a no Kelemania e uku hou aku iā 2 mau manawa hou aku.

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I nā manawa maʻi e hoʻopiʻi pū i ka hopohopo poʻomanaʻo, nele i ka hoʻowalewale ʻana, ke hiamoe nei, ʻo ia hoʻi i ka hopena o ke papa lāʻau. ʻO kēia nā hōʻailona o ka haʻalele. ʻO ia ke kumu e laʻa ai ka hōʻemi ʻana i ka dosage, a lawe ʻia nā antidepressants ma hope o ka mālama ʻana. Hoʻomaʻa maikaʻi nā kauka i nā hapanui i kēia lāʻau lapaʻau.

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ʻO ka manaʻo o ke Kauka

Ua wehe ʻo Tebantin i nā mea hou aku i ka mālama ʻana i ka ʻeha neuropathic a me nā ʻeha hou aʻe. He nui kona mau pono:

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ka ulu maʻalahi ma o ka pale koko-lolo,
nele i ka launa pū me nā protein koko,
huehuei huakini,
loaʻa
ua hōʻike ʻia ka hopena ma ka hoʻomaʻamaʻa e like me ka hōʻike ʻana i nā lāʻau lapaʻau,
maikaʻi ʻoluʻolu
mālie o ka hoʻohana.

ʻAʻole pili ka mea ola i nā enzyme o ke kō a me ka ʻokoʻa. ʻO ka lāʻau lapaʻau ke koho maikaʻi ma ka mālama ʻia ʻana o nā mea maʻi ma muli o ka maʻi makua, ma muli o ka ʻōlelo lapaʻau maikaʻi ʻo ka pharmacokinetic a me ke kiʻekiʻe o ka palekana. ʻO nā hopena ʻaoʻao, ua emi iki ka hoʻohālikelike ʻana me nā carbamazepines. Ma hope o hoʻokahi pule, ua manaʻo ka mea maʻi i kahi holomua.

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ʻO kaʻoiaʻiʻo, ʻaʻole ʻo ka panepepa ʻo Tebantin. Akā ke kōkua i nā mea hoʻomaʻamaʻa e hoʻoponopono i nā hihia koʻikoʻi inā he ikaika a i ʻole ka hoʻoweliweli ʻia nā lāʻau ʻē aʻe me nā papa inoa o nā contraindications a me nā hopena ʻaoʻao.

ʻLoe a me ke kākele

Lawe ʻia nā Capsules me ke ʻano ʻole o ka ʻai ʻana, ʻaʻole inu ʻia, ʻū ʻia a piha ʻia me ke kō o ka wai.

Ma kahi o nā mea kikowaena hapa, e hōʻoia ai i ka hopena antiepileptic no nā maʻi pākeke a me nā keiki ma mua o 12 mau makahiki o Tebantin, ua kauoha ʻia ʻo Tebantin i kahi dosis o 900-1200 mg i kēlā me kēia lā. Nā hoʻoponopono lula mālama:

Kiʻi A: ka lā mua - 300 mg (100 mg ʻekolu i ka lā a i ʻole 300 mg hoʻokahi), ka lua o ka lā - 600 mg (200 mg ʻekolu mau manawa a i ʻole 300 mg ʻelua i ka lā), ke kolu o ka lā - 900 mg (300 mg ʻekolu lā i ka lā), ka lā ʻehā - 1200 mg (400 mg ʻekolu mau manawa i ka lā),
Kāleka B: ka lā mua - 900 mg (300 mg ʻekolu mau manawa i ka lā), ma nā lā aʻe, hiki iā ʻoe ke hoʻonui i ka lāʻau i kēlā me kēia lā i 1200 mg (400 mg ʻekolu mau manawa i ka lā).

ʻO ka palena loa o kēlā me kēia lā o Tebantin ʻo 2400 mg (800 mg ʻekolu mau manawa i ka lā).

ʻOi no ka lāʻau lapaʻau hou no nā mea hoʻohilahila, ma nā keiki he 3-12 mau makahiki me ke kaumaha o ke kino ma mua o 17 kg e kuhikuhi ʻia he 25-35 mg / kg o ke kino kino i kēlā lā, i hoʻokaʻawale ʻia i ʻekolu mau puʻupuʻu. Hoʻokomo ʻia nā dosa hoʻomaka:

nā keiki mai 3 a hiki i ka 12 mau makahiki me ke kaumaha o ke kino he 17-25 kg: ke lā mua - 200 mg i ka lā hoʻokahi, ka lā ʻelua - 200 mg ʻelua i ka lā, ke kolu o ka lā - 200 mg ʻekolu mau manawa i ka lā.
kamaliʻi keiki he 3 a 12 mau makahiki me ke kaupaona kino o ke kino ma mua o 26 kg: ka lā mua - 300 mg i hoʻokahi lā, i ka lā ʻelua - 300 mg ʻelua i ka lā, ʻo ke kolu o ka lā - 300 mg ʻekolu mau manawa i ka lā.

Hoʻomaka mai ka lā ʻehā o ka hōʻola, hiki ke hoʻonui ʻia ka nui o ka lālani gabapentin i 35 mg / kg i kēlā me kēia lā i ʻekolu mau puʻupuʻu i hoʻokaʻawale ʻia. Wahi a nā noiʻi hauoli, ʻo ka hapa o nā lāʻau lapaʻau ma 40-50 mg / kg i kēlā me kēia lā i hoʻomanawanui maikaʻi ʻia e nā mea maʻi.

No ka mālama ʻana i nā maʻi kau i kēlā me kēia lā no nā keiki he 3 a 12 paha makahiki, me ke kaumaha o ke kino:

17-25 kg - 600 mg pākahi
26-36 kg - 900 mg pākahi
37-50 kg - 1200 mg pākahi
51-72 kg - 1800 mg pākahi.

No ka hōʻeha o ka neuropathic ma nā maʻi pākeke ma mua o 18 mau makahiki, ua hoʻokumu ʻia ke ʻano o Tebantin e ka titration, me ka noʻonoʻo ʻana i ka hopena o ka hopena a me ka hoʻomanawanui i ka lāʻau. ʻO ka hapa nui o kēlā me kēia lā he 3600 mg i kēlā me kēia lā i ʻekolu mau puʻupuʻu.

Nā hoʻoponopono lula mālama:

Kiʻi A: ka lā mua - 300 mg (100 mg ʻekolu i ka lā a i ʻole 300 mg hoʻokahi), ka lua o ka lā - 600 mg (200 mg ʻekolu mau manawa a i ʻole 300 mg ʻelua i ka lā), ke kolu o ka lā - 900 mg (300 mg ʻekolu mau lā i ka lā)
Kuhi B (no ka ʻeha nui): ka lā mua - 900 mg (300 mg ʻekolu mau manawa i ka lā), ma nā lā 7 aʻe, hiki iā ʻoe ke hoʻonui i ka maʻi i kēlā me kēia lā i ka 1800 mg i kēlā me kēia lā.

ʻO nā maʻi me ka kaumaha o ke kino haʻahaʻa, nāwaliwali a me nā mea maʻi e hele ai i ka hoʻololi kino ʻana, e hoʻonui iki i ka nui, ʻaʻole iʻoi aku ma mua o 100 mg i kēlā me kēia lā.

Ma ka hana hoʻopihapiha (inā he kuhi ma lalo o ka 80 ml / min) ka poʻe ʻelemakule me ka hoʻokaʻawale ʻana i nā creinine clearance a me nā mea maʻi ma ka hemodialysis, koho ʻia ke ʻano o ka maʻi o Tebantin, e ʻae ʻia ana me ke kiʻekiʻe o ka hana kino.

Hoʻohui nūhou

Ke hoʻohui i ka gabapentin me nā lāʻau antiepileptic e hōʻemi ana i ka pono o nā kūlohelohe waha, hiki ke hōʻemi a e pani paha i ka hopena contraceptive o nā lāʻau kūpono.

Pono e lawe ʻia nā capsules i nā hola 2 ma hope o ka lawe ʻana i nā aniani e loaʻa ana i ka alumina a i ʻole ka magnesium, no ka mea i ka manawa like, ʻike ʻia lākou i ka bioavailability o gabapentin e 24%.

Hoʻemi iki ka Cimetidine i nā excretion o gabapentin e nā keiki, ʻaʻole iʻike i ke kauka.

Me ka hoʻohana pū ʻana me ka ethanol a me nā lāʻau hōʻeha e pili ana i ka nūnaehana nūnū, hiki ke hoʻonui ʻia ka hopena o ka ʻaoʻao o Tebantin mai ka ʻōnaehana waena.

Ke hui pū ʻia me nā anticonvulsants ʻē aʻe, aia kekahi mau hopena o ka hopena maikaʻi ʻole i ka hoʻoholo ʻana i ka huina o ka protein i loko o ka urine e hoʻohana ai i nā hoʻokama semi-quantitative (ua makemake ʻia e hoʻohana i nā ʻano lāʻau kūikawā).