Reduxin® (Reduxin)

Loaʻa ka Reduxine i ke ʻano o nā capsules: ka nui no ka 2, ka uliuli a me ka polū, nā keʻokeʻo a i ʻole keʻokeʻo paha nā ʻāpana polū o ke aila (10 kēlā me kēia i nā palaka, ma kahi kāwele pepa o 3 a 6 mau ʻeke paha).

Nā mea waiwai (i ka 1 kapsul):

• Nā cellulose Microcrystalline - 158.5 mg a i ʻole 153.5 mg,
• ʻO Soharine'ōmaʻomaʻa kahikina monamina (10 mg a 15 mg paha.

Nā mea kōkua: calcium stearate.

ʻO ka mana o nā pūpū o ka capsule: gelatin, dye titanium dioxide, ka peʻa i ke aniani i ke aniani, ka peʻa azorubine (nā kāwili 10 mg).

Nā Hoʻohui

• Nā kahe aihue paʻa ʻole (kahe koko a ma luna o 145/90 mm Hg)
• ʻO ka maʻi ʻeha Coronary, nā maʻi kīlipia o ka puhipuhipuhi, nā arrhythmias, nā puʻuwai naʻau congenital, decompensated ka paʻa naʻau aʻai ʻole, tachycardia, nā maʻi cerebrovascular (ka maʻi hoʻokele cerebrovascular hou, ka maʻa).
• ʻO ka hopena o ka huehue a me / hana kōpaʻa,
• Kohu nui,
• ʻO nā maʻi noʻonoʻo
• ʻO nā maʻi ʻai nui (bulimia nervosa a i ʻole anorexia),
• Benign prostatic hyperplasia
• ʻO ka heleʻana o nā kumu kūlohelohe (hypothyroidism, etc.),
• Thyrotoxicosis,
• Hono
• Nākā i nā lāʻau lapaʻau, ʻona a wai ʻole hoʻi e hilinaʻi nei,
• Puhmuhiwa,
• ʻO ka hoʻohana like ʻana o nā antipsychotics, antidepressants a me nā mea kanu ʻē aʻe e hana ana i ka ʻōnaehana nūnaehana,
• ʻO ka hoʻohana like ʻole a lawelawe ʻana paha no 2 mau pule ma mua o ka koho ʻana o Reduxine monoamine oxidase inhibitors (e.g. ephedrine, ethylamfetamine, fenfluramine, phentermine, dexfenfluramine),
• Ka hoʻohana ʻana i nā lāʻau lapaʻau e hōʻemi i ke kaumaha o ke kino waena, a me nā lāʻau lapaʻau e pili ana i ka tryptophan a kuhikuhi i nā maʻi hiamoe.
• Na keiki malalo o na makahiki 18
• ʻŌpū a me ka lactation
• ʻOi aku ka ʻelemakule ma mua o 65,
• Hypersensitivity o kekahi o nā lāʻau o ka lāʻau.

Relative (lawe i ka lāʻau lapaʻau me ka mālama):

• Hypertension hypertension (mōʻaukala a hoʻokele),
• Hoʻopau ʻole ke kala uila,
• ʻO ka mōʻaukala o nā arrhythmias,
• He maʻi maʻi nā neʻe Coronary (me ka mōʻaukala o)
• Hoʻopiʻi ka hana a me / a me ka hana pono o ka moʻolelo a me ke ʻano maʻalahi.
• Kelolia,
• Ka mōʻaukala o nā waha a me nā ʻenikini,
• ʻO nā maʻi neurological, e komo pū ana me nā mākaukau a me ka hoʻokaʻawale ʻana o ka noʻonoʻo (me kekahi mōʻaukala).

ʻLoe a me ke kākele

Lawe ʻia nā capsu Reduxine i hoʻokahi lā i ka lā, ma mua o ka papa ʻaina a i ʻole i ka wā o ka pāʻina. Komi ʻia ka pahu kapo piha a holoi ʻia me ka nui o ka wai a i ʻole nā ​​wai wai ʻē aʻe.

Hoʻonohonoho ʻia ka lāʻau pākahi a hilinaʻi ma luna o ke hoʻomanawanui o ka lāʻau a me kona hopena kūpaʻa. ʻO ka maʻa mua ka maʻamau 10 mg. Inā hōʻemi maikaʻi ʻia ka lāʻau lapaʻau, hiki iā ʻoe ke hoʻomaka me ka 5 mg.

Me ka hoʻohaʻahaʻaʻana i ke kaupaona o ke kino ma o ka mea ma lalo o 5% i ka malama mua o ka hōʻola, ua hoʻonui ʻia ka nui o ka lāʻau i 15 mg i kēlā me kēia lā. I nā poʻe maʻi ʻaʻole i nalowale i ka 5% a i ʻole o ko lākou kaumaha mua i loko o 3 mau malama, ua mālama ʻia ka mālama ʻana. ʻAʻole hoʻomau ʻia ka lāʻau ʻoiai inā paha, ma hope o ka pohō ʻana o ke kaupaona, hoʻohui hou ka mea maʻi i ka 3 kg a i ʻole.

ʻO ka lōʻihi o ka lōʻihi o ka mālama ʻana i ka Reduxin ma mua o 2 mau makahiki, ʻoiai ʻaʻole he ʻikepili i ka palekana a me ka pono o ka lāʻau lapaʻau me ka lōʻihi o ka lāʻau.

Hoʻolaha ʻia ka mālama ʻia ma lalo o ka mākaʻi ʻana o kahi kauka me kahi ʻike kūpono i ka hakakā ʻana i ka momona. Hoʻomaopopo ʻia ka Therapy e hui pū me nā hoʻomaʻamaʻa a me ka meaʻai.

ʻĀpana Pharmacological

Lapaʻau lāʻau

ʻO Reduxin ® kahi mea i hoʻohui ʻia nona ka hana ma muli o kāna mau ʻāpana.

Kahalawai he prodrug a hoʻopuka i kona hopena i vivo ma muli o nā metabolites (ka mua a me nā ʻōmua helu) e keakea nei i ka hoʻouluulu ʻana o nā monoamines (serotonin, norepinephrine a me dopamine). ʻO ka hoʻonui nui aʻe o ka ʻike o ka neurotransmitters i loko o nā synapses e hoʻonui i ka hana o ke kikowaena 5-HT-serotonin a me nā taliaina adrenergic, kahi mea i loaʻa i ka hoʻonui i ka satiety a me ka hoʻohaʻahaʻa i ka koi o ka meaʻai, a me ka hoʻonui i ka hana thermal. Hoʻokomo-kū ʻole i ka beta₃-adrenoreceptors, hana ka sibutramine i ka brown adipose tissue. ʻO ka hoʻohaʻahaʻa o ke kaupaona kino me ke piʻi ʻana o ke kaila o ka plasma o ka HDL a me ka hoʻohaʻemi ʻana i ka helu o ka triglycerides, ka nui kolesterol, LDL a me ka waikū uric. ʻAʻole hoʻopilikia ʻo Sibutramine a me nā metabolites i ka hoʻokuʻu ʻana o nā monoamines, mai pale i ka MAO, he haʻahaʻa haʻahaʻa no ka nui o nā mea hoʻokae o ka neurotransmitter, me nā serotonin (5-HT₁5-NT_1A5-NT_1B5-NT_2C)) adrenergic (beta₁-, beta₂-, beta₃-, alpha₁-, alpha₂-), dopamine (D₁, D₂), muscarinic, histamine (N₁), nā mea kanu benzodiazepine a me kahi glutamate (NMDA).

MCC ʻO ia he enterosorbent, loaʻa nā waiwai sorption a me kahi hopena detoxification non-spesial. Hoʻopili a hoʻopau i nā microorganisms like ʻole, nā huahana o kā lākou hana koʻikoʻi, nā mea o nā mea exogenous a me ka endogenous ʻano, allergens, xenobiotics, a me ka nui o kekahi mau mea metabolic a me nā metabolites i kuleana no ka hoʻomohala ʻana i nā meaʻala endogenous.

Lapaʻau lāʻau

Ma hope o ka lawelawe waha, ua hoʻoiho koke ʻia mai ka hana a ka digestive ma kahi o 77%. I ka wā mua o ka mahelehele o ka ate, ka mea e hoʻomoʻa ana i ka biotransformation ma lalo o ka mana o ka isoenzyme CYP3A 4 me ka hoʻokumu ʻana i nā metabolites kūwaho - monodesmethylsibutramine (M1) a me didesmethylsibutramine (M2). Ma hope o hoʻokahi pākahi kau he 15 mg C_max i loko o ke koko koko, he M1 ka 4 ng / ml (3.2–4.8 ng / ml), ʻo M2 ka 6.4 ng / ml (5.6-7.2 ng / ml). C_max loaʻa ma hope o 1,2 hola (sibutramine), 3-4 hola (M1 a me M2). ʻAno ʻai ʻokoʻa haʻahaʻa C_max nā metabolites e 30% a hoʻonui i ka manawa e hōʻea iā ia ma 3 mau hola me ka ʻole e hoʻololi i ka AUC. Hāʻawi koke ʻia ia ma nā lole. ʻO ke kamaʻilio me nā protein he 97 (sibutramine) a me 94% (M1 a me M2). C_{ai ʻo ss} hiki ke hōʻea ʻia nā metabolites aktif i loko o ke kaila koko i loko o 4 mau lā ma hope o ka hoʻomaka ʻana o ka hoʻohana ʻana a ma kahi o 2 mau manawa ka neʻe o ka plasma koko ma hope o ka lawe ʻana i hoʻokahi pākahi. T_1/2 sibutramine - 1,1 hola, M1 - 14 mau hola, M2 - 16 mau hola.Mino e hōʻola ka metabolites ikaika i ka hydroxylation a me ka hui pū ʻana me ka hoʻokumu ʻana o nā metabolites hana ʻole, ka mea i hoʻopuka nui ʻia e nā keiki.

Nā hui ahonui kūikawā

Paul ʻAʻole ʻike nā ʻikepili i kēia manawa i ka noho ʻana o nā ʻokoʻa koʻikoʻi o nā maʻi i ka pharmacokinetics i nā kāne a me nā wahine.

Mamua. ʻO ka pharmacokinetics i nā kamaliʻi olakino olakino (makahiki maʻamau - 70 mau makahiki) ua like ia me ka poʻe ʻōpio.

ʻO Renal hiki ʻole. ʻAʻole hoʻopilikia ka hana i ka Renal i ka AUC o ka metabolite ikaika M1 a me M2, koe wale nō ka M metabolite M2 i nā mea maʻi me ka hopena o ka renal end-stage e hana ana i ka dialysis.

ʻO ka hana hema ʻole. I nā maʻi me ka hōʻemi ʻana o ka puʻuwai maʻalahi ma hope o hoʻokahi pākahi o ka sibutramine AUC, ʻo nā metabolite ikaika M1 a me M2 he 24% kiʻekiʻe ma mua o nā kānaka olakino.

ʻŌpū a me ka lactation

Mai ka wā ʻaʻole i nui ka nui o nā noiʻi e pili ana i ka palekana o ka hopena o nā sibutramine ma luna o ka pūpū, ua hoʻohālike ʻia kēia lāʻau lapaʻau i ka wā hāpai.

Pono nā wahine o nā makahiki hānau o ka hānau ʻana i ka wā o ka lawe ʻana iā Reduxin ®.

Ua hoʻohālikelike ʻia e lawe iā Reduxin ® i ka wā o ka ʻōpū.

Nā hopena hopena

ʻO ka pinepine, loaʻa nā hopena ʻeha i ka hoʻomaka o ka mālama ʻana (i nā 4 mau pule mua). Nūwili ʻia ko lākou koʻikoʻi a me ka wikiwiki o ka wā. ʻO nā hopena ʻaoʻao ka lahilahi a hoʻololi ʻia. Hoʻopuka ʻia nā hopena ʻaoʻao, e pili ana i ka hopena ma nā ʻōpala a me nā ʻōnaehana o ka pūnaehana: a pinepine ʻia (≥10%), pinepine (≥1%, akā, ʻo ke kikowaena neʻe waena: ka manawa pinepine loa - ka waha maloʻo a me ka insomnia, pinepine - kahi o ke poʻo, ka ʻeha, ka hopohopo, ke paresthesia, a me ka loli ma ka ʻono.

Mai CCC: pinepine - tachycardia, palpitations, hoʻonui i ke koko, vasodilation.

Ke hoʻonui ʻia ʻana o ke kahe o ke koko ma ka hoʻomaha ʻana e 1-3 mm Hg i nānā ʻia. a me ke hoʻonui ʻana o ka naʻau ma 3-7 e kāʻākiʻi / min. I kekahi mau hihia, ʻaʻole e hoʻokaʻawale ʻia ke ʻano o ka nui o ka nui o ke koko a me ka puʻuwai naʻau. Ua hoʻololi nui ʻia nā loli koʻikoʻi o ka pehu o ke koko a me ka pulse i ka hoʻomaka ʻana o ka mālama ʻana (ma nā pule he 4-8 mua).

ʻO ka hoʻohana ʻana o Reduxin ® i nā mea maʻi me ke koko koko kiʻekiʻe: e ʻike i nā "Contraindications" a me "Nānā Hoʻohui kūikawā".

Mai ka pūnaehana hana ʻana: pinepine pinepine - lilo i ka makemake a me ka constipation, pinepine - i ka hanu a me ka exacerbation o hemorrhoids. Me ka manaʻo o ka constipation i ke ao mua, pono ʻia ka mālama ʻana i ka hana o ka hoʻokipa ʻana o ka ʻōpū. Inā hele i ka constipation, kāpae i ka lawe a lawe i ka laxative.

Ma ka ʻāpana o ka ʻili. pinepine - hoʻonui i ka ʻoli.

Ma nā hanana lohi, ʻo ka hoʻōla me ka sibutramine i wehewehe i nā mea iʻike ʻole ʻia e ka maʻi nui: dysmenorrhea, edema, flu-like syndrome, hōʻeha o ka ʻili, ʻeha hoʻi o ka ʻōpū, ka ʻōpū, ka hoʻonui ʻana i ka ʻai, ka makewai, ka rhinitis, ke kaumaha, ka hiamoe, ka hana naʻau, ka hopohopo, ka huhū, ka huhū, nephritis interstitial koi, koko, Shenlein-Genoch purpura (hemorrhage i ka ʻili), kaʻaila, thrombocytopenia, hoʻonui pinepine i ka hana o nā enzyme o ka lolo i ke koko.

Ma ke ʻano o nā noi ʻana ma hope-kūʻai aku, ua hōʻike ʻia nā ʻano ʻoi aʻe hou aʻe, i hōʻike ʻia ma lalo nei, e nā ʻōnaehana organ:

Mai CCC: atrial fibrillation.

Mai ka pānaʻi: nā hopena maʻi hypersensitivity (mai ke kapa i hōʻeha i ka ʻili a me ka urticaria i ka angioedema (ka edema Quincke) a me ka anaphylaxis).

Nā maʻi noʻonoʻo; psychosis, haʻi ʻana o ka noʻonoʻo suicidal, pepehi i a me mania. Inā loaʻa kēlā mau ʻano, pono e hoʻoneʻe ʻia ka lāʻau lapaʻau.

Mai ka ʻōnaehana hoʻonāukiuki: pōpoki pōkole, pōkole ke hoʻomanaʻo ʻana.

Mai ka ʻaoʻao o ke kino o ka hihiʻo. pupule pālule (pale i mua o nā maka).

Mai ka pūnaehana hana ʻana: nā ʻeha, hoʻohemo.

Ma ka ʻāpana o ka ʻili a me ka kiko. alopecia.

Mai nā pūpū a me ka maʻi urinary: mālama urinary.

Mai ka ʻōpiopio: ejaculation / orgasm disorders, impotence, menstrual irregularities, uterine blood.

Hoʻohui

Nā mea hoʻohiwahiwa o ka microsomal oxidation, ʻo ia hoʻi inhibitor o ka isoenzyme CYP3A 4 (me ka ketoconazole, erythromycin, cyclosporin) e hoʻonui i nā kukuna plasma o nā metabolite sibutramine me ka hoʻonui ʻana i ka puʻuwai o ke kino a me ka hoʻonui pinepine ʻana i nā maʻi ma waena o ka QT.

ʻO Rifampicin, antibiotic macrolide, phenytoin, carbamazepine, phenobarbital a me dexamethasone hiki ke hoʻoikaika i ka hana o ka sibutramine. ʻO ka hoʻohana like ʻana o kekahi mau lāʻau lapaʻau e hoʻonui ai i ka ʻike serotonin i loko o ke koko koko hiki ke alakaʻi i ka hoʻolālā ʻana i kahi hopena koʻikoʻi. Ma nā hanana lohi, me ka hoʻohana pinepine ʻana i ka lāʻau Reduxin ® me SSRIs (nā lāʻau lapaʻau no ka mālama ʻana i ke kaumaha), hiki i kekahi mau lāʻau lapaʻau no ka mālama ʻana i ka migraine (sumatriptan, dihydroergotamine), potent analgesics (pentazocine, pethidine, fentanyl) a i nā lāʻau antitussive (dextromethorphan) hiki ke ulu. serotonin syndrome.

ʻAʻole hoʻopilikia ka Sibutramine i ka hopena o nā mea hoʻohālikelike waha.

Me ka hoʻomohala pinepine ʻana o ka sibutramine a me ka waiʻona, ʻaʻohe hopena i hopena maikaʻi ʻole o ka waiʻona. Eia naʻe, ʻaʻole i hui pū kekahi me ka waiʻona me nā ana meaʻai i makemake ʻia i ka wā e lawe ai i sibutramine.

Me ka hoʻohana like ʻana o nā lāʻau lapaʻau me ka sibutramine e hoʻopiʻi ana i ka hemostasis a i ʻole ka platelet e hana, e hoʻonui ʻia ka hōʻemi o ke koko.

Ke hoʻomaopopo nei ka lāʻau lapaʻau me ka hoʻohana pinepine ʻana o sibutramine me nā lāʻau lapaʻau e hoʻonui nui ana i ke koko a me ka puʻuwai naʻau i kēia manawa ʻaʻole i maopopo loa. ʻO kēia pūʻulu o nā lāʻau lapaʻau e komo ai i nā lāʻau decongestants, antitussive, anu a me nā anti-alani, kahi e loaʻa ai ka ephedrine a i kahi pseudoephedrine paha. No laila, i nā hihia o ke kāʻei ʻana i kēia mau lāʻau me ka sibutramine, pono e mālama nui ʻia. ʻO ka hoʻohana pū ʻana o ka sibutramine me nā lāʻau lapaʻau e hōʻemi i ka paona kino, ke hana nei ma ke ʻano nū o ka nūnū waena, a i ʻole nā ​​lāʻau lapaʻau no ka mālama ʻana i nā pilikia noʻonoʻo.

ʻLoe a me ke kākele

I loko I kekahi lā, i ke kakahiaka, me ka ʻaina ʻole a inu i ka wai nui (ʻo kahi kīʻaha wai). Hiki i ka lāʻau ke loaʻa nā mea ʻelua ma ka ʻōpū ʻole a hoʻohui ʻia me kahi pāʻina.

Hoʻonohonoho ʻia ka ʻākala i kēlā me kēia, ka mea i hilinaʻi ʻia a me ke kūpaʻa ʻana o ka maʻi. ʻO ka papa hoʻomaka ʻia he 10 mg / lā. Inā i loko o 4 mau hebedoma mai ka hoʻomaka ʻana o ka hoʻomaʻamaʻa, ʻo ke emi ʻana o ke kaumaha o ke kino e emi iho ma mua o 2 kg o ka hoʻokō, a laila piʻi ka nui i ka 15 mg / lā.

Pono e mālama hou ʻia ka maʻi Reduxin ® ma mua o 3 mau mahina i nā maʻi i pane ʻole i ka lapaʻau, i.e. aia ia ma loko o 3 mau malama o ka mālama e hiki ke hoʻokō i kahi emi o ke kino ma o 5% mai ka hōʻailona kumu. ʻAʻole hoʻomau ʻia ka mālama inā inā, me ka ʻoi aku ka lāʻau hou ma hope o ka hōʻemi ʻana o ke koʻikoʻi o ke kino, hoʻonui ke kino o ke kanaka maʻi i ka 3 kg a i ʻole.

ʻAʻole hiki ke lōʻihi ka lōʻihi o ka mālama ʻana i ka makahiki 1, no ka mea he lōʻihi lōʻihi o ka lawe ʻana i ka sibutramine, pono a me ka ʻike palekana.

Pono e mālama ʻia ʻo Reduxine ® i ka papa me kahi ʻaʻai a me ka hana ma lalo o ka mākaʻi ʻana o ke kauka me ka ʻike pono i ka mālama ʻana i ka momona.

Ke keu

Nā Hoʻomaka ua palena iki nā mea e pili ana i ka overdose o ka sibutramine. ʻO nā hopena ʻino loa e pili ana me ka overdose ʻo ia ka tachycardia, hoʻonui i ke koko, ke poʻo, ka ʻōpū. Pono ka mea maʻi e hoʻomaopopo i kā lākou mea mālama olakino inā pilikia ka overdose.

Lāʻau: ʻAʻohe mea lapaʻau kūikawā a i ʻole nā ​​antiidote kikoʻī. Pono e hoʻokō i nā ʻoihana holoʻokoʻa: e hōʻoia i ka hanu ʻana ʻole, ke nānā pono i ke kūlana o CVS, a me ia, inā pono, e hoʻokō i ka hōʻailona maʻi maʻi. ʻO ka hoʻokele manawa ʻana o nā carbon carbon, ʻo ia hoʻi, me ka gastric lavage, hiki ke hōʻemi i ka waiwai o ka sibutramine i loko o ke kino. ʻO nā mea maʻi me ke koko koko kiʻekiʻe a me ka tachycardia e kuhikuhi ana i nā beta-blockers. ʻAʻole paʻa i ka hopena o ka diuresis i ʻole a i ʻole hemodialysis.

Nā ʻōlelo kikoʻī

Pono e mālama ʻia me ka Reduxine ® ma ke ʻano he lāʻau paʻakikī i ka pohō kaumaha ma lalo o ka mākaʻi ʻana o kekahi kauka me kahi ʻike kūpono i ka mālama ʻana i ka momona.

Ua komo pū ka lāʻau kaumaha me kahi loli i ka ʻai a me ke ʻano, a me ka hoʻonui ʻana i ka hana kino.

ʻO kahi mea nui o ka lapaʻau ka hana ʻana i nā pono no ka loli mau ʻana o ka ʻai ʻana i ka lawena a me ke ʻano hana, pono pono e mālama i ka hoʻemi ʻia ʻana o ke kaupaona ʻana o ke kino ma hope o ka hoʻopau ʻana i ka lāʻau lapaʻau. ʻO kahi ʻāpana o ka hopena me Reduxin ®, pono e hoʻololi i nā mea maʻi i ko lākou ola a me nā ʻano no laila ma hope o ka hoʻomaʻamaʻa ʻana o ka mālama ʻana e mālama lākou i ka hōʻemi ʻia o ka paona kino.

E hoʻomaopopo pono ka poʻe maʻi i ka hiki ʻole o kēia hoʻokō ʻana i kēia mau koi, e hana hou i ka nui o ke kaumaha o ke kino a me ke kipa pinepine ʻana i ke kauka.

I nā maʻi e lawe ana i ka Reduxin ®, pono ia e ana i ke kiʻekiʻe o ke koko a me ka puʻuwai puʻuwai. Ma nā 3 mau mahina mua o ka mālama ʻana, pono e nānā ʻia kēia mau ʻōhua i kēlā me kēia 2 hebedoma, a laila ʻo ka mahina. Inā hiki i nā wā e kipa aku ai i ka nui o ka puʻuwai ma ka hoʻomaha i ka ʻ rest10 be10 beats / min a i ʻole CAD / DBP ≥10 mm Hg i ʻike ʻia , pono ʻoe e ho'ōki i ka mālama ʻana. ʻO nā mea maʻi me ka ha maʻi hypertension, ma ia mea, e kū'ē ana i ke kuʻuna o ke ʻano antihypertensive, ʻoi ke kahe o ke koko ma mua o 145/90 mm Hg. , pono e mālama pono ia kēia mana a, inā pono, i nā wā pōkole ʻoi aku. ʻO nā mea maʻi i hoʻoilo ʻia ke koko ma ʻelua mau manawa i ke ana me ka nui o ka 145/90 mm Hg. , pono e hoʻopau ʻia ke mālama me Reduxine ® (e nānā. "ʻaoʻao ʻaoʻao").

I nā maʻi me ka hiamoe apnea hiamoe, pono e mālama pono i ke kahe koko.

Pono ka nānāʻana i ka mālama like ʻana o nā lāʻau lapaʻau e hoʻonui ai i ka palena QT. ʻO kēia mau lāʻau lāʻau ka histamine H blockers.₁nā mea hopu (astemizole, terfenadine), nā lāʻau antiarrhythmic e hoʻonui i ka waena QT (amiodarone, quinidine, flecainide, mexiletine, propafenone, sotalol), gastrointestinal motility stimulator cisapride, pimozide, sertindole a me tricyclic antidepressants. Hoʻopau kēia i nā kūlana i hiki ke alakaʻi i ka mahuahua ma waena o ka QT (hypokalemia a me hypomagnesemia - ʻike i ka "Interaction").

ʻO ka mole ma waena o ka hoʻokomo o MAO inhibitors (me ka furazolidone, procarbazine, selegiline) a me ka lāʻau lapaʻau Reduxin ® pono ma kahi o 2 mau pule.

ʻOiai ʻaʻole i hoʻokū ʻia ka pilina ma waena o ka lawe ʻana iā Reduxin ® a me ka hoʻomohala ʻana o ka hypertension pulmonary maʻamau, eia nō naʻe, ka hāʻawi ʻia ʻana o ka pilikia no kēia pūʻulu o nā lāʻau lapaʻau, me ka mālama ʻana i nā lapaʻau maʻamau, pono e uku ʻia i nā maʻi e like me ka progrsp dyspnea holomua (ʻeha o ka hanu), ʻeha ʻeha a me ka ʻīhī ʻana o nā wāwae. . ^ E Ha yM.

Inā hele ʻoe i kahi maʻa o Reduxin ®, ʻaʻole pono ʻoe e lawe ʻelua ʻelua i ka lāʻau i ka hopena hou aʻe, ʻoi aku nei e hoʻomau ʻoe e lawe i ka lāʻau e like me ka papa kuhikuhi.

ʻAʻole lōʻihi ka lōʻihi o ka lawe ʻana ʻana iā Reduxin ® i hoʻokahi makahiki.

Me ka hoʻohana pū ʻana o ka sibutramine a me nā SSRI ʻē aʻe, loaʻa ka nui aʻe o ke kahe koko. I nā mea maʻi i hoʻomaka mua i ke koko, me ka lawe ʻana i nā lāʻau i pili i ka hemostasis a i ʻole ke ʻano o ka platelet, pono e hoʻohana ʻia nā sibutramine me ka akahele.

ʻOiai ʻaʻole loaʻa ka ʻikepili lapaʻau e pili ana i ka hoʻohui ʻana i ka sibutramine, pono e ʻike ʻia inā he mau hanana o ka paulele ʻana i ka moʻolelo o ka mea maʻi a mālama pono i nā hōʻailona o ka hōʻalo i ka lāʻau lapaʻau.

Aia ʻo Sibutramine no ka papa inoa o nā mea waiwai nui, i ʻae ʻia e ka Mokuʻu o ke Aupuni o ka Lūkini Lūkini o Dekemaba 29, 2007 No. 964.

Hoʻopilikia i ka hiki ke hoʻokau i nā kaʻa a me nā māka. ʻO ka lawe ʻana iā Reduxine ® hiki i ka mea palena ke hiki i kāu kaʻa ke hoʻokele i nā kaʻa a hana i nā mīkini. I ka wā o ka hoʻohana ʻana i ka lāʻau Reduxin ®, pono e mālama pono i ka wā e hoʻokele i nā kaʻa a komo i nā hana ʻē aʻe e pili ana i ka pōʻino e koi nui no ka nānā ʻana a me ka wikiwiki o ka hopena psychomotor.

Mea hana

LLC "Ozone". 445351, Rusia, Wana Samara, Zhigulevsk, ul. Sand, 11.

Tel./fax: (84862) 3-41-09.

ʻO ʻAmelika Hui Pū ʻIa Kūlana ʻo Mīkini "Moscow Endocrine Plant". 109052, Moscow, st. Novokhokhlovskaya, 25.

Tel./fax: (495) 678-00-50 / 911-42-10.

Ka helu a me ka helu kelepona o kahi hui i hōʻoia ʻia no ka hoʻokaʻaʻike (hoʻopiʻi a me nā hoʻopiʻi): LLC PROMOMED RUS. 105005, Rusia, Moscow, ul. Malaya Pochtovaya, 2/2, p. 1, pom. 1, lumi 2.

Tel .: (495) 640-25-28.

Hoʻohui nūhou

Erythromycin, ketoconazole a me cyclosporine e hoʻonui i ka plasma o ke kaila o nā metabolite sibutramine me ka hoʻonui ʻana o ka puʻina o ka puʻuwai a me nā hoʻonui hou aku i ka maʻi o ke kikowaena QT.

ʻO Phenytoin, rifampicin, phenobarbital, carbamazepine, dexamethasone a me nā antibiotika macrolide hiki ke hoʻōla i ka metabolism ʻo Reduxin.

Me ka hoʻohana pū ʻana me ka potolo analgesics (pethidine, pentazocine, fentanyl), kekahi mau lāʻau lapaʻau no ka mālama ʻana i ka migraine (dihydroergotamine, sumatriptan), nā lāʻau antitussive (dextromethorphan) a me nā lāʻau lapaʻau no ka mālama ʻana i ke kaumaha, ma nā hihia loaʻa, hiki i ka hoʻomohala ʻana o ka maʻi serotonin.

ʻAʻole pili ʻo Reduxin i ka hopena o nā mea hoʻohālikelike waha.

Me ka hoʻokūkū pinepine ʻana me ka ethanol, ʻaʻole i ʻike ʻia kahi hoʻonui ʻana i nā hopena maikaʻi ʻole o ka hopena. Eia nō naʻe, kūpono ʻole ka waiʻona i nā kaʻina hana i mālama ʻia i ka wā e mālama ai.

Nā hōʻailona no ka hoʻohana ʻana

Kuhi ʻia ʻia ʻo Reduxin no ka hoʻolilo ʻana i ke kaupaona ʻana ma ke alo o nā ʻano haki:

• ʻO ka momona hanu me ke ʻano huina o ke kino (BMI) o 27 kg / m 2 a i ʻole ke hoʻohui pū me nā mea ʻē aʻe e pili ana i ka nui o ka maʻi (non-insulin-depend diabetes mellitus, dyslipoproteinemia),
• ʻO ke kaumaha o Alimentary me BMI o 30 kg / m 2 a i ʻole.

Nā ʻōkuhi no ka hoʻohana ʻana iā Reduxin: kaʻina a me ka dosis

Pono ʻia ka Reduxine i hoʻokahi lā i ka lā, i ke kakahiaka, ke kī ʻana i nā pōpoki holoʻokoʻa a inu i ka wai me ka nui o ka wai, ma ka ʻōpū ʻole a i ʻole ke kau ʻana i ka pāʻina.

ʻO ka papa hoʻomaka ʻana he 10 mg. Inā ma loko o nā hebedoma 4 ʻaʻole hiki i ka hoʻokō kūpono ʻana i ke kaupaona ʻana i ke kaumaha o ke kino ma ka liʻiliʻi o 5%, hoʻonui ʻia ka nui o kēlā me kēia lā i 15 mg.

ʻAʻole pono ka lōʻihi o ka lōʻihi o ka mālama ʻana ma mua o 2 mau makahiki (ma muli o ka nele o ka ʻikepili i ka palekana a me ka hana pono o ka hoʻohana ʻana i ka sibutramine).

Inā ma loko o 3 mau mahina ʻaʻole emi ke emi ʻana o ke kaumaha o ke kino ma ka liʻiliʻi o 5% o ka paona mua, ua oki ʻia ʻo Reduxin. ʻAʻole hoʻomau ʻia ka mālama inā inā, me ka hoʻokele hou ʻana o ka lāʻau lapaʻau, hoʻohui hou ka mea maʻi i 3 kg a ʻoi paha ka nui o ke kaumaha.