Nā ʻōlelo wanana a Wessel Douai F: nā ʻōlelo aʻoaʻo no ka hoʻohana

ʻO nā māka Antithrombotic. Sulodexide.

PBX code B01A B11.

• Hōʻea ka Angiopathies me ka piʻi nui o ka thrombosis, incl. he thrombosis ma hope o ka halaʻi myocardial infarction
• maʻi maʻi cerebrovascular: stroke (stroke ischemic stroke a me ka hoʻihoʻi hou ʻana ma hope o kahi hōʻeha)
• discirculatory encephalopathy i kumu ʻia e ka atherosclerosis, diabetes mellitus, hypertension arterial, a me ka vascular dementia,
• nā maʻi kūloko o ka mākina pelipila o nā atherosclerotic a me ka hoʻomaka ʻana i ka maʻi maʻi
• phlebopathy a me ka thrombosis urin hohonu
• nā microangiopathies (nephropathy, retinopathy, neuropathy) a me nā macroangiopathies (maʻi wāwae maʻi diabetes, encephalopathy, cardiopathy) ma muli o ka maʻi maʻi,
• ʻōpio thrombophilia, ʻeha antiphospholipid
• heparin thrombocytopenia.

ʻLoe a me ke kākele

ʻōlelo aʻo nui

ʻO nā regimens lapaʻau maʻamau i loaʻa i ka lawelawe makua ma ka lāʻau lapaʻau i ukali ʻia e nā capsules; i kekahi mau mea, hiki ke hoʻomaka pololei ka mālama ʻana me Sulodexide mai nā capsules. Hiki ke hoʻohālikelike ʻia ka hoʻoponopono koʻikoʻi a me nā pilike i kūpono e like me ke hoʻoholo a ke kauka ma ke kumu o ka hōʻike loiloi a me nā hopena o ka hoʻoholo ʻana i nā ʻōkuhi lāʻau.

Ma keʻano holoʻokoʻa, e noi ʻia e lawe ʻia nā kapakai ma waena o nā papaʻaina, inā i hoʻokaʻawale ʻia ka nui o nā lā o nā capsules i loko o kekahi mau iniha, ʻo ia ke kumu no ka mālama ʻana i kahi hola 12 i waena o nā hopena o ka lāʻau.

Ma ka laulā, ua kuhikuhi ʻia ke papa holoʻokoʻa o ka mālama ʻana e hana hou ʻia ma ka manawa 2 mau manawa i ka makahiki.

Hōʻea ka Angiopathies me ka piʻi nui o ka thrombosis, incl. he thrombosis ma hope o ka halaʻi myocardial infarction

I ka mahina mua, ke mālama ʻia nā inikini intramuscular o 600 LO o ka sulodexide (nā huaʻomo o 1 ampoule) i kēlā me kēia lā, ma hope ke hoʻomau ʻia nei ke ʻano o ka mālama ʻana, ka lawe ʻana i nā kapo he 1-2 mau a ʻelua i kēlā me kēia lā (500-1000 LO / lā). Hiki ke loaʻa nā hopena maikaʻi inā hoʻomaka ka mālama ʻana i loko o nā lā 10 mua ma hope o kahi hanana o ka maʻi myocardial acute.

ʻO ka maʻi cerebrovascular: ka maʻi (ʻo stroke ischemic stroke a me ka hoʻomaka hou ʻana ma hope o kahi hōʻeha)

Hoʻomaka ka mālama maʻi i nā lā o kēlā me kēia lā o 600 LO o ka sulodexide a i kahi bolus a i ʻole ka drip infusion, no ka mea ka pau nā kikoʻī o 1 ampoule o ka lāʻau lapaʻau i ka 150-200 ml o ka paʻakai physiological. ʻO ka lōʻihi o ka infusion mai 60 mau minuke (wikiwiki ka 25-50 mau minuke / min) a i 120 mau minuke (wikiwiki ka wikiwiki 35-65 mau minuke / min). ʻO ka manawa kūpono no ka mālama ʻana i nā lā 15-20. A laila, e hoʻomau ʻia ka lāʻau lapaʻau me ka hoʻohana ʻana i nā ʻōlau, i lawe ʻia ma ka 1 capsule i ʻelua mau manawa i kahi lā (500 LO / lā) no 30-40 mau lā.

Atherosclerosis-induced discirculatory encephalopathy, diabetes mellitus, hypertension arterial, and vascular dementia

Manaʻo ʻia e lawe i 1-2 mau pulapika o ka lāʻau lapaʻau ʻelua i kēlā me kēia lā (500-1000 LO / lā) orally no ka 3-6 mahina. Hiki ke hoʻomaka o ka papa o ka mālama ʻana me ka hoʻomaka ʻana o ka 600 LO sulodexide i kēlā me kēia lā no 10-30 mau lā.

ʻO nā maʻi ākea o ka arela peripheral o nā atherosclerotic a me ka hoʻomakaʻana i ka maʻi maʻi

Hoʻomaka ka mālamaʻana i ka hoʻokele intramuscular i kēlā me kēia lā o 600 LO sulodexide a hoʻomau mau no 20-30 mau lā. A laila hoʻomau ʻia ka papa hana, e lawe ana i ka 1-2 kapapika a ʻelua paha i ʻelua manawa i ka lā (500-1000 LO / lā) no 2-3 mau mahina.

ʻO Phlebopathy a me ka thrombosis vein hohonu

Kūkākūkā pinepine ʻia ka hoʻoponopono waha waha o sulodexide capsules i kahi maʻa o ka 500-1000 LO / lā (2 a i ʻole 4 mau kapa) no 2-6 mau mahina. Hiki ke hoʻomaka o ka papa o ka mālama ʻana me ka hoʻolaha o ka lā i kēlā me kēia lā o 600 LO sulodexide i kēlā me kēia lā no 10-30 mau lā.

ʻO Microangiopathies (nephropathy, retinopathy, neuropathy) a me nā macroangiopathies (maʻi wāwae maʻi maʻi, encephalopathy, cardiopathy) ma muli o ka maʻi maʻi

ʻO ka mālama ʻia ʻana o nā maʻi e hōʻeha nei i ka micro- a me macroangiopathies i ʻelua mau manawa. ʻO ka mea mua, mālama ʻia ka 600 LOs o ka sulodexide i kēlā me kēia lā no 15 mau lā, a laila hoʻomau ʻia ka mālama ʻana, e lawe ʻia ana he mau lā 1-2 lā ʻelua i kēlā me kēia lā (500-1000 LO / lā). ʻOiai me ka mālama pōkole o nā hopena pōkole e hiki ke nalo i nā hopena, e pono e hoʻonui i ka lōʻihi o ke kaona ʻelua o ka mālama ʻana i ka liʻiliʻi ma 4 mau mahina.

ʻO ka maʻi thrombophilia, ʻeha antiphospholipid

ʻO ka hoʻoponopono regimen maʻamau e pili ana i ka hoʻokele waha o 500-1000 LO sulodexide i kēlā me kēia lā (2 a i ʻole nā ​​4 mau kōmaʻa) no 6-12 mau mahina. ʻO kaʻaila Sulodexide e kuhikuhi pinepine ma hope o ka mālama ʻana me ka haʻahaʻa kaumaha heparin i hui pū ʻia me ka acetylsalicylic acid, a ʻo ka nui o ka pauku dosage o ka mea hope loa, ʻaʻole pono e loli.

heparin thrombocytopenia

I ka hihia o ka heparin, thrombocytopenia, ʻo ka hoʻomakaʻana o ka heparin a i ʻole ka molaki haʻahaʻa heparin heparin e hoʻololi i ka infusion o sulodexide. No ka hana ʻana i kēia, nā wai o ka 1 ampoule o ka lāʻau (600 LO sulodexide) e hoʻoheheʻe ʻia i 20 ml o 0.9% huina sodium klorida a lawelawe ʻia ma ke ʻano o ka infusion wikiwiki no 5 mau minuke (wikiwiki 80 hāʻule / min). Ma hope o kēlā, ke hoʻoheheʻe ʻia nei nā 600 LOs o ka sulodexide ma 100 ml o 0.9% hoʻonā sodium chloride a lawelawe ʻia ma ke ʻano o nā minuke 60 mau minuke (wikiwiki 35 hāʻule / min) i kēlā me kēia hola a hiki i ka pono o ka lāʻau anticoagulant.

ʻO nā hopena ʻino

ʻO ka ʻike aʻe e pili ana i nā hopena ʻino i nānā ʻia i nā hoʻokolohua lapaʻau e pili ana i nā mea maʻi 3258 e hoʻohana ana i nā maʻi maʻamau a me nā hoʻoponopono hoʻoponopono.

ʻO nā hopena ʻino e pili ana me ka hoʻohana ʻana i ka sulodexide, ka mea i hoʻonohonoho ʻia e like me nā papa o nā pūnaehana a me ka pinepine. Ke hana ʻia ka ʻologylelo ma lalo nei e hoʻoholo i ka neʻe o ka hopena leʻa: mau pinepine (≥ 1/10), pinepine ʻia (mai ≥ 1/100 a i ʻole

Ke keu

ʻO ka overdose o ka lāʻau hiki ke alakaʻi i ka hoʻomohala ʻana o nā hōʻailona hemorrhagic, e like me ka hemorrhagic diathesis a i ʻole he koko. I ka hihia o ke kahe, e hoʻokaʻa ʻia he 1% hoʻonā o ka protamine sulfate. Ma keʻano holoʻokoʻa, me ka overdose, pono e hoʻokaʻawale ke hoʻohana ʻana i nā lāʻau a pono pono ke hoʻomaka i ka lāʻau hōʻailona.

Hoʻohana i ka wā hāpai a lactation

No ka mea ʻaʻohe ʻike me ka hoʻohana ʻana i ka lāʻau lapaʻau i ka lāʻau mua o ka hapai, ʻaʻole pono ke kau ʻia nā wāhine i ka lāʻau i loko o kēia manawa ke ʻole, inā ʻaʻole, i ka manaʻo o ke kauka, ka mea i manaʻo ʻia e pono ai ka mālama ʻana i ka makuahine i ka hiki ʻana i ka hopena maʻi.

Aia ke palena palena ma ka hoʻohana ʻana o sulodexide i loko o ka lua a me ke kolu o ka hapaha o ka hapaha no ka mālama ʻana i nā hoʻopiʻi vascular i hoʻokumu ʻia e ka type I a me ke ʻano type II a me ka maʻi laʻa. I kēlā mau hihia, ua mālama ʻia ka sulodexide i kēlā me kēia lā i ka intramuscularly ma ke ʻano o ka ʻUmea 600 LO no ka lā no 10 mau lā, ma hope o ke ʻano o ka lawelawe waha ʻana i ka lāʻau i manaʻo ʻia no ka 1 kapule ʻelua i ka lā (500 LO / lā) no 15-30 mau lā. I ka hihia o nā mea laʻawaʻa, hiki ke hoʻohui pū i kēia lāʻau lapaʻau me nā ʻano kuʻuna o ka lapaʻau.

I ka wā o ka II a me III e hoʻomaʻamaʻa ʻia no ka hapai, pono e hoʻohana ʻia ka lāʻau lapaʻau me ka mālama aka, ma lalo o ka mālama o kahi kauka.

ʻAʻole i ʻike ʻia inā ua exode ka sulodexide a i ʻole nā ​​metabolites i loko o ka waiū umauma. No laila, no nā kumu palekana, ʻaʻohe pono e koho i nā wahine i ka wā lactation.

He palena waiwai ka nui o ka hoʻohana ʻana o ka hoʻomākaukau sulodexide ma ka mālama ʻana i ka nephropathy maʻi me ka glomerulonephritis i loko o nā ʻōpio ʻo ka makahiki 13-17 mau makahiki. I kēlā mau hihia, ua lawelawe ʻia ʻo 600 LO o ka sulodexide i ka intramuscularly i kēlā me kēia lā no 15 mau lā, a laila 1-2 mau kāpala o ka lāʻau i lawelawe lelo ʻia i ʻelua lā i kahi lā (500-1000 LO / lā) no 2 mau pule.

ʻAʻole ʻike nā ʻikepili e pili ana i ka hopena a me ka palekana o ka lāʻau lapaʻau ma nā keiki ma lalo o 12 makahiki.

Nā hiʻohiʻona noi

I ka wā o ka mālama ʻana, hiki i nā loina hemocoagulation (hoʻoholo i ka coagulogram) e nānā ʻia ka manawa maʻamau. I ka hoʻomaka a ma hope o ka pau ʻana o ka hoʻomaʻamaʻa ʻana, pono e hoʻoholo ʻia nā ʻōkuhi o ka hope: hoʻāla i ka ʻāpana part thromboplastin, ka manawa koko a me ka manawa coagulation, a me ka pae antithrombin III. Ke hoʻohana nei i ka lāʻau lapaʻau, hoʻonui ka nui i ka manawa thromboplastin ka nui i ka manawa 1,5.

ʻO ka hiki ke hoʻokaumaha i ka hopena o ka hopena i ka wā e holo a hana paha me nā hana ʻē aʻe.

Inā nānā ʻia ka huki ʻana i ka wā o ka mālama ʻana, pono e hōʻalo i kahi kaʻa kaʻa a hana pū me nā hana.

ʻO nā waiwai Pharmacological

Lapaʻau. ʻO Wessel Douay F ka hoʻomākaukau ʻana o ka sulodexide, kahi ʻano kūlohelohe o ka glycosaminoglycans i kaawale mai ka ʻōpū o ka ʻōpū o ka puaʻa, ka ʻano o ka heparin-like me ke kaumaha o ke kumu lāʻau o ka 8000 Da (80%) a me ka dermatan sulfate (20%).

ʻO Sulodexide ka mana antithrombotic, anticoagulants, profibrinolytic a me ka angioprotective hopena.

ʻO ka hopena anticoagulants o ka sulodexide ma muli o kona pilina me ka cofactor heparin II, hoʻopaʻa i ka thrombin.

Hoʻololi ʻia ka hopena antithrombotic o ka sulodexide e ka pale ʻana i ka hana a Xa, e hāpai ana i ka synthesis a me ka huna ʻana o ka prostacyclin (PGI2) a me ka hoʻemi ʻana i ka pae o ka fibrinogen plasma.

ʻO ka hopena profibrinolytic ma muli o ka hoʻonui o ka hana o ka kiko plasminogen kiko a me ka hoʻemi ʻana i ka hana o kāna mea pale.

Hoʻopili ka hopena angioprotective i ka hoʻihoʻi ʻana o ka hana a me ka hana pono o nā sela endothelial a me ka hana o ka hoʻokaʻina ʻana o ka hiʻona o ka hoʻopiʻi maikaʻi ʻana o nā membrane pae vascular.

Eia kekahi, hoʻololi ka sulodexide i ka waiwai o ka rheological o ke koko ma o ka hoʻohaʻahaʻa ʻana i ka pae o ka triglycerides (kahi i pili pū me ka hana o nā lipoprotein lipase, ka enzyme e pili ana i ka hydrolysis o triglycerides).

Hoʻoholo ʻia ka maikaʻi o ka lāʻau i ka nephropathy maʻi ma o ka hiki ʻana o nā sulodexides e hōʻemi i ka mānoanoa o nā membement basement a me ka hana ʻana o ka matika intercellular ma o ka hoʻemi ʻana i ka hoʻomaikaʻi ʻana o nā cell mesangium.

Lapaʻau lāʻau Hoʻomoʻaʻia ka Sulodexide i loko o nā mea liʻiliʻi. ʻO 90% o ka pauku e lawelawe ʻia ana o ka sulodexide e hōʻiliʻili i ka endothelium vascular, kahi o kona neʻe ʻana he 20-30 mau manawa kiʻekiʻe ma mua o ke kahe ʻana o nā umu o nā kino ʻē aʻe. Hoʻomili ʻia ka Sulodexide e ka ʻāo, a hoʻoulu ʻia e nā keiki. Ma ka hoʻohālikelike ʻana me ka hoʻokaʻawaleʻana o nā mea kiʻekiʻe heparaction a me ka haʻahaʻa heparin, desulfate i ka ʻauʻau, e hiki ai i ka emi ʻana o nā hana antithrombotic a me ka wikiwiki o ka hopena o ka sulodexides, ʻaʻole i make. I nā haʻawina o ka hoʻoili ʻana o ka sulodexide, hōʻike ʻia ma ke kiʻi ʻia ua hao ʻia e nā pōpoki me kahi hapa o ka hapa i hiki ke 4:00.

Pono-hemahema

ʻO ka sulodexide ka polysaccharide me nā waiwai waikona, i ka wā e lawelawe ʻia me ka hui pū ʻana, hiki iā ia ke hana i nā ʻupena me nā mea ʻē aʻe e loaʻa nā mea waiwai. ʻO nā mea aʻe i hoʻohana nui ʻia no ka inikui extemporal i hoʻohui ʻole ʻia me ka sulodexide: vitamina K, kahi paʻakikī o nā huaora B, hyaluronidase, hydrocortisone, calcium gluconate, paʻakai ammonium quaternary, chloramphenicol, tetracycline a me streptomycin.