Presartan N

ʻO ka lāʻau me ka hopena antihypertensive, e pili ana i nā lāʻau lapaʻau, kahi mea i paʻa. hoʻopiha nā mea paʻi (type AT1) ʻAʻole ke keʻokeʻo i ka enzyme (kinase II) ka mea luku bradykinin. ^ E Ha yM. He haʻahaʻa ka presartan koko aldosterone a norepinephrine, OPSS, HANʻI, e hōʻemi i ka hapalua, ka pomi i loko o ka "liʻiliʻi" pali o ke kahe koko, he hopena diuretic. Mālama i ka hoʻomohala ʻana o ka hypertrophy myocardial. I nā maʻi me CHF hoʻonui i ka pale ʻana i ka hoʻoikaika kino.

Ma hope o hoʻokahi ka wai o Presartan, hiki i ka hopena antihypertensive ka piʻiʻana o kona waiwai nui ma hope o 6 mau hola, a ke emi iki nei ma ka lā aʻe. Hōʻike ʻia ka hopena hypotensive kiʻekiʻe ma ka mahina hoʻokahi ma hope o ka hoʻomaka ʻana o ka mālama ʻana me ka lāʻau lapaʻau.

Presartan, nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana (Ke ʻano a me ke ʻano)

Lawe ʻia ʻo Presartan e pili ana i ka ʻai ʻana o ka meaʻai, 1 manawa i kēlā me kēia lā. I ka mālamaʻana haehae maʻi fautuaina ʻia kēlā me kēia lā o 50 mg, kahi, inā pono, hiki ke hoʻonui ʻia i 100 mg. I ka hihia e lawe ai ka mea maʻi i nā nui kiʻekiʻe o nā diuretics, pono e hoʻemi ʻia ka nui o ka dosage i 25 mg i kēlā me kēia lā.

No ka mālama ʻana CHF ʻo ka laʻana mua o kēlā me kēia lā he 12.5 mg, lawe ʻia i ka manawa, a laila, me ka manawa o hoʻokahi pule, ua hoʻonui ʻia ke kauka ma ka 2 manawa (12.5, 25, 50 mg). ʻO ka papa mālama mālama he 50 mg i kēlā me kēia lā. No ka hoʻoikaika i ka hopena hypotensive, ʻoi aku ia e kuhikuhi Presartan N (Losartan me nā mea antihypertensive).

Hoʻohui

Hoʻohana pinepine ʻia o ka lāʻau lapaʻau me nā lāʻau lapaʻau e pili ana i ka paʻakai (hoʻomākaukau pāpaʻi, Diuretics pākoleka-sparing) hoʻonui i ka pilikia o ka hoʻomohala ʻana hyperkalemia. ^ E Ha yM. Hiki i ka hui pū ʻana o ka lawe ʻana i ka lāʻau me ka diuretics e hiki ai ke waiho i kahi hāʻule uaka HANʻI. ^ E Ha yM. Hoʻohui nui ʻana o Presartan me Nā NSAID kōkua ia e hōʻemi i ka hopena hypotensive o ka lāʻau. Me ka mālama like ʻana o ka lāʻau lapaʻau me nā lāʻau lapaʻau antihypertensive, ʻokoʻa hopena hypotensive.

E hoʻokuʻu i ke ʻano a me ka ʻano

ʻO ka palapala hoʻohālikelike o Presartan he mau ʻāpana papa kīwī: ma ke kaona o 25 a 50 mg - biconvex a puni, ʻulaʻula, 25 papa papa me kahi laina hoʻokaʻawale i kahi ʻaoʻao, ma kahi pākuʻi o 100 mg - ka pihi piha, biconvex, keʻokeʻo a ʻokoʻa keʻokeʻo me ke kahakaha " 100 "ma kekahi ʻaoʻao a me" BL "ma kekahi (10 pcs. I kahi kue, 3 koli i loko o kahi pahu pahu, he 14 mau pcs.

Kāleka 1 papa 25/50 mg:

• mea ikaika: losartan potassium - 25/50 mg,
• ʻO nā mea kōkua a pau: nā māhu maloʻo, cellulose microcrystalline, pure talc, colloidal silicon dioxide, sodium starch glycolate, magnesium stearate, isopropyl alkohol, methylene chloride, opadry OY-55030, crimson dye red.

Wāwae 1 papa 100 mg:

• mea ikaika: losartan potassium - 100 mg,
• ʻO nā mea kōkua: ka pauka palaoa, microcrystalline cellulose, talc, colloidal silicon dioxide, sodium carboxymethyl starch, magnesium stearate, hypromellose, titanium dioxide, talc, macrogol.

Lapaʻau lāʻau

Hoʻokomo koke ʻia ʻo Presartan mai ka gastrointestinal tract (GIT). Hoʻomoe ma mua e ka hele i ka nalo. ʻO ka hōʻailona o ka pilina o ka protein protein o losartan a me nā metabolites ka 92-199%. Bioavailability - 33% (ʻaʻohe hopena o ka intake meaʻai). ʻAʻole maikaʻi ka lāʻau lapaʻau i ka pale ʻana i ke koko-lolo. ʻAʻole e hōʻiliʻili i ke kino, lawe ʻia ka excretion me ka urine a me ka bile. ʻO ka hapalua hapalua o losartan he 2 mau hola.

Nā hōʻailona no ka hoʻohana ʻana

• hypertension arterial a waiho aku ai i ka hypertrophy ventricular (e hoʻemi i ka hopena o ka hoʻolālā ʻana i nā pathologies cardiovascular a me ka make ma ke ʻano).
• type II diabetes mellitus me ka proteinuria (e hoʻemi i ka hopena o ka proteinuria a me ka hypercreatininemia),
• Hoʻohana ʻia ka pilikia puʻuwai me he ʻāpana o ka hui ʻana i ka wā hiki ʻole ke hoʻohana i ka angiotensin e hoʻohuli ai i ka enzyme (ACE) inhibitors.

Nā Hoʻohui

• hōʻeha maikaʻi o ka puʻu ˃ 9 mau pihi ma ka pānaʻi o ke keiki-Pugh (no nā papa 100 mg),
• hapai a me lactation,
• makahiki i 18 makahiki
• hoʻonui mahuahua i nā ʻaoʻao Presartan.

ʻO nā contraindications pili (no nā papa 100 mg):

• kohola
• pālahalaha maʻi
• maʻi pālohelohe i ka wā o ka hana mua me nā ACE inhibitors a i nā lāʻau lapaʻau ʻē aʻe,
• ʻOiaʻiʻo
• maʻi maʻi ʻōnaehana
• ka hoʻemi ʻana i ka nui o ke koko (BCC),
• haehae
• ka pilina ʻana me ka lālani anti-inflammatory non-steroidal (NSAIDs),
• maʻi maʻi coronary
• holomua.

Nā ʻōkuhi no ka hoʻohana ʻana i Presartan: ʻano a me ka helu ʻana

ʻO nā papa presartan e lawe maʻamau ʻia i ka manawa 1 i ka lā, me ke ʻano o ka ʻai ʻana o ka meaʻai.

Hōʻike ʻia

• hypertension arterial: ʻo 25 mg / la mau manawa i manaʻo ʻia ʻia, ʻo ka ʻawaʻawa awelika he 50 mg / lā, inā pono, hiki ke hoʻonui ʻia i 100 mg / lā, aʻo ka lawe ʻana i ka lāʻau 2 mau manawa i kahi lā i ʻae ʻia.
• ka hewa pākahi: ke kaukau ʻia nei i ka ʻōmole mua loa he 12.5 mg / lā, lawe ʻia ka dosis titration me kahi hebedoma. ʻO ka awelika mālama mālama pono he 50 mg / lā,
• ka pale ʻana o nā maʻi cardiovascular a me ka make ma ka poʻe maʻi me ka hypertension arterial a me ka hypertrophy ventricular haʻalele: ʻo ke ʻano neʻe mua ʻia he 50 mg / lā, a laila e hoʻonui ʻia ka 100 mg / lā, a i ʻole ka hoʻohui i kahi o ka hydrochlorothiazide i ʻōlelo ʻia.
• mellitus maʻi II ʻano me ka proteinuria: ʻo ke ʻano neʻe mua i hōʻike ʻia ʻo 50 mg / lā, a laila e hoʻonui ʻia i 100 mg / lā.

Nā hui maʻi maʻi maʻi:

• ake aho (points 9 mau kuhi ma ka helu keiki-Pugh), ka lawe ʻana i nā koina kiʻekiʻe o ka diuretics, hemodialysis, ʻoi aku ma mua o 75 mau makahiki: ʻaʻole pono ka nui o ka hopena o ka lāʻau i ka 25 mg / lā
• hana hana aho ka hemahema: pono e hoʻohana ʻia nā make i lalo o ka lāʻau.

Nā hopena hopena

ʻO Presartan ma kahi pānaʻi o 25 a me 50 mg ka maʻa maʻamau. Hiki i nā hopena ʻaoʻao ke ʻano o ka maʻi ʻana, ka dyspepsia, ka ʻehaʻeha, ka huhū, ke poʻo, ka hōʻeha ʻana, ke ʻano hiamoe, hyperkalemia (pākaʻomo o ka paʻakai> 5.5 meq / l), i nā hihia lohi, ka huhū, ka hāʻule ʻole o ka hanu, tachycardia, angioedema ( lehelehe, alo, pharynx a / a i ʻole e ʻōlelo ai), urticaria, hoʻonui i ka hana o nā ʻoli o nā ate, pae nui serum bilirubin.

Hiki i nā hopena hopena ke wā e lawe i nā papa presartan ma loko o kahi 100 mg:

• cardiovascular system: tachycardia, palpitations, nosebleeds, dosis e pili ana orthostatic hypotension, arrhythmias, bradycardia, vasculitis, angina pectoris, myocardial infarction,
• digestive system: ʻeha, ʻeha o ka ʻōpū, nausea, dyspepsia, maloʻo mucosa maloʻo, anorexia, luaʻi, hōʻea ka maʻi, constipation, gastritis, flatulence, hepatitis, ʻeha ate lēwa;
• musculoskeletal system: nā ʻalā o nā ʻUwā o ke keiki, hope a me ka ʻeha hope, arthralgia, ʻaeʻeha, ʻeha ma ka poʻohiwi, kuli, fibromyalgia,
• ʻili: ʻili, keʻa maloʻo, ʻokohu, photosensitivity, alopecia, hoʻonui nui ʻia
• nā maʻi kūlike: ka ʻāʻī o ke kino, kaʻeha, ka urticaria, angioedema (me ka edema o ka larynx, alana),
• hematopoiesis: thrombocytopenia, eosinophilia, kuhihewa iā Schoenlein - Genoch, ka hoʻokaʻawale ʻana i ka hemoglobin a me ka hematocrit,
• nā rula: ʻeha, hopohopo, hopohopo, hopohopo, ke hiamoe nei, nā keokeo moe, nā hana hoʻomanaʻo, hoʻomanaʻo ʻana, paresthesia, hyposthesia, neuropathy peripheral, lūlū, ataxia, pōpilikia, tinnitus, nāhelehele, hōʻeha hopohopo, migraine, conjunctivitis, ʻikeʻino,
• pūnaehana hanu: kaū, pharyngitis, bronchitis, nasalest congestion, sinusitis, upper respiratory tract infection,
• ʻōnaehana genitourinary: i ka maʻi urinary tract, peremptory urination, impalired renal function, hoʻemi i ka libido, ka hemahema,
• nā mea ʻē aʻe: ashenia, umauma ʻeha, luhi, edema peripheral, exacerbation o ke ʻano o ka gout,
• nā kaukaʻi ʻana i ka makahiki: ʻo hyperuricemia, ka nui o ka piʻi ʻana o ka urea, residual nitrogen a me ka hana ʻana i loko o ka serum koko, he nui o ka hana o nā transaminases hepatic (moder), hyperbilirubinemia.

Nā ʻōlelo kikoʻī

ʻAe, ke hoʻomaka ʻoe e lawe iā Presartan, pono ʻoe e hoʻoponopono i ka dehydration i kumu, no ka laʻana, me ka lawe ʻana i nā diuretics ma nā papa kiʻekiʻe, inā ʻaʻole hiki ke hoʻoponopono hou i ka BCC, pono e hoʻomaka ka mālama ʻana me ka liʻiliʻi haʻahaʻa o ka lāʻau.

ʻO nā lāʻau hōʻeha i ka RAAS (renin-angiotensin-aldosterone system) hiki ke hoʻonui i ka kaomi o ka urea i ke koko a me ka serum creatinine i nā mea maʻi me ka bilateral renal artery stenosis a i ʻole ka stenosis o hoʻokahi artery kidney.

Hoʻokomo i ka hiki ke lawe i nā kaʻa a me nā mīkini paʻakikī

ʻAʻole i lawelawe ʻia nā noiʻi kūikawā e pili ana i nā hopena o Presartan ma ka hiki ke hoʻokele i nā kaʻa a me nā mīkini ʻē aʻe. Eia nō naʻe, pono e noʻonoʻo ʻia i ka hoʻolālā ʻana o nā hopena paha, e like me ka hiamoe a me ka dizziness, e koi ai i ka nui o ka mālama ʻana i ka wā e hoʻomaʻamaʻa ana i nā hana e pili ana.

Hoʻohui nūhou

• Diuretics potassium-sparing, ka hoʻomākaukau ʻana i ka pālea: ka loaʻa ʻana o ka hoʻoulu ʻana i ka hyperkalemia,
• diuretics: ʻo ka loaʻa ʻana o ka hua o ka nui o ke emi ʻana i ke koko,
• beta-blockers a me ka sympatholytics: hoʻonui i ko lākou hopena,
• rifampicin, flucanazole: hoʻemi i ka hoʻouluʻana o ka metabolite hoʻoikaika o losartan i loko o ke koko,
• lithium: hiki ke hoʻonui ʻia i loko o kona neʻe ʻana i ke koko,
• Nā NSAID: ua hōʻemi ʻia ka hopena hypotensive o ka lāʻau,
• nā lāʻau lapaʻau antihypertensive ʻē aʻe: hoʻonui ʻia kā lākou hopena hypotensive.

ʻO nā analogues o Prezartan ʻo Brozaar, Blocktran, Vazotens, Zisakar, Kozaar, Lozap, Cardomin-Sanovel, Losartan, Renicard, Lakea, Vero-Lozartan, Lorista.

Pehea e hoʻohana ai: dosis a me ke ʻano o ka mālama ʻana

Lawe ʻia nā papa presartan N me ka wahaheʻe, me ka mālama ʻole o ka meaʻai.

ʻO ka papa mua a me ka mālama mālamaʻana he 1 papa 12.5 mg + 50 mg 1 manawa i kēlā me kēia lā. Loaʻa ka hopena antihypertensive kiʻekiʻe i loko o ʻekolu mau pule o ka hoʻomehana. No ka hoʻokō ʻana i kahi hopena hou aku, hiki nō ke hoʻonui i ka nui o ka lāʻau ma ke papa ʻelua i ka papa ʻelua o 12.5 mg + 50 mg hoʻokahi i ka lā. ʻO ka palena loa o kēlā me kēia lā he 2 mau papa o Presartan N.

I ka poʻe maʻi me ka hoʻohaʻahaʻa nui o ke koko kahe koko (no ka laʻana, ʻoiai e lawe ana i nā koina nui o ka diuretics), ʻo ke ʻano kumu mua o ka losartan i nā mea maʻi me ka hypovolemia he 25 mg hoʻokahi i ka lā. Ma kēia noʻonoʻo, pono e hoʻomaka ʻia ka lāʻau me Presartan N ma hope o ka hoʻopau ʻia o ka diuretics a me ka hoʻoponopono ʻana o ka hypovolemia.

I nā poʻe maʻi a me nā mea maʻi me ka maikaʻi ʻole o ka hoʻololi ʻana i ka renal, me ka poʻe ma ka dialysis, ʻaʻohe koi mua o ka hoʻoponopono hoʻoponopono ʻia.

ʻO ka hōʻemi ʻana i ka hopena o ka morbidity cardiovascular a me ka make ma ka poʻe maʻi me ka hypertension arterial a waiho aku i ka ventricular hypertrophy

ʻO ka maʻa kumu mua o ka losartan he 50 mg 1 manawa i kēlā me kēia lā. ʻO nā mea maʻi ʻaʻole hiki ke hoʻokō i ka pīhaʻi koko a ʻoiai e lawe ana i ka losartan 50 mg / lā e pono ai ka mālama ʻana me ka hui pū ʻana o losartan me nā haʻahaʻa haʻahaʻa o hydrochlorothiazide (12.5 mg), a inā pono, e hoʻonui ʻia ka pā o losartan i ka 100 mg i hui pū me ka hydrochlorothiazide ma ka make o 12,5 mg / lā, i ka wā e hiki mai ana - hoʻonui i ka 2 papa o ka lāʻau lapaʻau ma ka nui o 50 / 12.5 mg i ka nui (100 mg o losartan a me 25 mg o ka hydrochlorothiazide i kēlā me kēia lā).

Ka hana lāʻau lapaʻau

ʻO Presartan H ka hui pū ʻana o losartan a me hydrochlorothiazide, nā mea ʻelua i loaʻa ka hopena antihypertensive hopena, e hoʻohaʻahaʻa ana i ke kahe koko (BP) i ka nui ma mua o kēlā me kēia māhele.

He Losagonan kikowaena angiotensin II receptor antagonist (subtype AT1) no ka hoʻokō waha. ʻO Losartan a me kāna metabolite hoʻonaninani hoʻoikaika (E 3174) i ka in vitro a i ka vivo ālai i nā hopena kino a pau o ka angiotensin II, me ke ʻano o ke kumu a me ke ala o ka synthesis. Hoʻopili paʻa ʻo Losartan i nā ʻae ʻana o ka AT1 a ʻaʻole ia i hoʻopaʻa ʻia a hoʻopaʻa ʻole paha i nā ʻona o nā ʻoniʻoni a me nā ala o ke kaona, he mea nui ka hana i ka hoʻohālike o ka hana o ka ʻōnaehana cardiovascular. Eia kekahi, ʻaʻole ka pale o ka losartan i ka angiotensin-hoʻohuli i ka enzyme (ACE) - kininase II, a, a no laila, ʻaʻole i pale i ka luku ʻana i ka bradykinin, no laila ke hoʻopili pololei ʻia nei nā hopena me ka pili me ka bradykinin (no ka laʻana o ka angioedema) i ka maʻamau.

Ke hoʻohana nei i ka losartan, ka haʻalele ʻana o ka manaʻo o ka manaʻo maikaʻi i ka mea huna renin e alakaʻi i ka hana o ka hana renin plasma. ʻO ka hoʻonui ʻana o ka hana renin alakaʻi i ka hoʻonui ʻana i ka angiotensin II i ke kaila koko. Eia nō naʻe, he hana antihypertensive a me ka hoʻohaʻahaʻa ʻana i ka paʻa o ka ald testosterone i loko o ke koko plasma e hoʻomau nei, e hōʻike ana i kahi blockade maikaʻi o nā receptors II kaomi. ʻO Losartan a me kāna metabolite hoʻoikaika e loaʻa i kahi pilina nui loa no ka poʻe ʻono o nā angiotensin ma mua o nā ʻoniʻoni na angiotensin P. ʻO ka metabolite kahe mea i nā manawa he40 ma mua o ka losartan.

Ma hope o kahi lime hoʻokahi waha, ʻo ka hopena antihypertensive (hoʻohaʻahaʻa i ka systolic a me ka diastolic blood pressure) hiki i ka nui loa ma hope o 6 mau hola, a laila e emi iki ana i loko o 24 mau hola. Hoʻopilikia ka hopena antihypertensive kiʻekiʻe i ka 3-6 mau pule ma hope o ka hoʻomaka ʻana o ka lāʻau.

ʻO Hydrochlorothiazide - kahi diuretic thiazide, hoʻonāukiuki i ka reabsorption o ka sodium, chlorine, potassium, magnesium ions i ka nealron distal, e kāpae i ka hoʻonuiʻana i ka calcium, uric acid. ʻO ka hoʻonui i ka renal excretion o kēia mau ʻīpika i ukali pū me ka hoʻonui ʻia o ka nui o ka urine (ma muli o ka wai o ka osmotic wai). Hoʻemi i ka nui o ka plasma koko, hoʻonui i ka hana o renin a me nā ʻōlelo huna aldoster. Ke lawe ʻia i loko o nā wai nui, hoʻonui ka hydrochlorothiazide i ka hoʻopiha o nā bicarbonates, aʻo ka hana lōʻihi e hoʻemi i ka ʻohi o ka kalima.

Hoʻoulu ka hopena antihypertensive ma muli o ka kaohi ʻana o ka nui o ke koko kaila (BCC), ka hoʻololi i ka reactivity o ka pā vascular, ka hoʻēmi ʻana i ka hopena pressor o vasoconstrictor amines (adrenaline, norepinephrine) a me ka hoʻonui ʻana i ka hopena hoʻopaleha ma ka ganglia. ʻAʻole pili i ka pilikia koko. Hoʻomaopopo ka hopena diuretic ma hope o nā hola 1-2, hiki i ka lōʻihi ma hope o 4 mau hola a lōʻihi i ke hola 6-12. Hōʻike ka hopena antihypertensive i nā lā 3-4, akā pono ʻia nā hebedoma e hoʻokō ai i ka hopena therapeutic maikaʻi loa.

Nā nīnau, nā pane, nā loiloi o ka lāʻau Presartan N

ʻO ka ʻikepili i hāʻawi ʻia e hana no nā lāʻau lapaʻau a me nā lāʻau lapaʻau. Aia nā ʻike e pili ana i ka lāʻau lapaʻau e pili ana i nā ʻōlelo i hoʻopili ʻia e ka mea hoʻopiʻi e ka mea hana. ʻAʻohe ʻikepili i hoʻopili ʻia ma kēia a ʻole kekahi ʻaoʻao o ka pūnaewele a mākou e hiki ke lawelawe ma kahi kūʻokoʻa no ka hoʻopiʻi pilikino i ka loea.

E hoʻokuʻu i ke ʻano, ka pūpū a me ka hoʻopiʻi Presartan N

ʻO nā papa ʻulaʻi, he melemele i ulana ʻia, he ʻōmaʻomaʻo biconvex, ma ka ʻāpana ʻāpana: ʻo ke kumu nui mai ke keʻokeʻo a kokoke i ke keʻokeʻo.

Nā mea kūʻai: ka waiʻona lactose 111.50 mg, cellulose microcrystalline 58 mg, kōpio pregelatinized 3 mg, huʻai palaoa 12 mg, silikone colloidal dioxide 1 mg, magnesium stearate 2 mg.

Hoʻolālā:
hypromellose 2.441 g, titanium dioxide 0.60 mg, talc 1.50 mg, macrogol-6000 0.40 mg, quinoline melina ʻulaʻula 0.058 mg.

14 ʻōpō. - nā kīpaha palemona (2) - nā ʻeke pepa.

ʻLoe a me ke kākele

Me ka hypertension arterial, ʻo ka inikua mua o kēlā me kēia lā he 25 mg, ka awelika o ka awelika o kēlā me kēia lā he 50 mg, ʻo ka manawa o ka hoʻokele he 1 manawa / lā.

Hoʻopilikia ka hopena hypotensive kiʻekiʻe ma 3-6 mau pule ma hope o ka hoʻomaka ʻana o ka lāʻau lapaʻau. Inā kūpono, hiki ke hoʻonui ʻia ke ʻano o ka lāʻau lapaʻau i 1 00 mg i kēlā me kēia lā. I kēia hihia, hiki ke lawe i ka lāʻau lapaʻau 2 mau manawa i kahi lā.

ʻO ka maʻi kumu mua no nā poʻe maʻi me ka loaʻa ʻole o ka naʻau he 12.5 mg 1 manawa / lā. ʻO ka pinepine, ka titrated o ka pāʻai i ka manawa o kēlā me kēia hebedoma (i.e. 12.5 mg / lā, 25 mg / lā. 50 mg / lā) i kahi awelika mālama mālama ʻia ʻo 50 mg 1 mau manawa / lā, e pili ana i ka hoʻomanawanui ʻana o ka mea maʻi i ka lāʻau lapaʻau.

I ka helu ʻana i ka lāʻau lapaʻau i nā mea maʻi e loaʻa ana i nā wai kiʻekiʻe o ka diuretics, pono e hoʻemi ʻia ka pualikoa mua i 25 mg 1 manawa / lā.

ʻO nā mea maʻi me ka hana ʻōiwi lēwa ʻole e hāʻawi ʻia i nā ʻōpū haʻahaʻa o losartan,

I nā poʻe maʻi ʻōpiopio, a me nā mea maʻi me ka hana ʻole ʻole lēpaʻa, me ka poʻe maʻi ma ka hemodialysis, ʻaʻohe pono e hoʻoponopono i ka hopena mua o ka lāʻau.

Hiki ke kuhikuhi ʻia ʻo Presartan me nā lāʻau lapaʻau antihypertensive. Hiki ke hoʻohana ʻia ʻo Losartan e pili ana i kahi koina o ka meaʻai.

Loaʻa ka hopena

Hoʻomaʻamaʻa mau ʻia ʻo Presartan. Hiki ke nānā ʻia: nā keokeo, ka dyspepsia, ʻehaʻeha o ka naʻau, ka huhū, ka dizziness, ka hoʻohālikelike hiamoe, ke poʻo, ka hopohopo, ʻo hyperkalemia (kāʻai i ke koko ma mua o 5.5 meq / l). Ma nā hanana lohi, hiki i ka lākē, ka hāʻule ʻana o ka hanu, ka tachycardia, angioedema (me ka nui o ka huehue ʻana o ka maka, nā lehelehe, pharynx a me / a i ʻole e ʻōlelo ai), urticaria, hoʻonui i ka hana o ka "melamin" transaminases, bilirubin i loko o ke koko.

Nā hiʻohiʻona noi

I ka poʻe maʻi me ka dehydration (no ka laʻana, ka loaʻa ʻana o ka mālama ʻana me nā dosis kiʻekiʻe o ka diuretics), hypotension hōʻailona paha e hoʻomaka i ka hoʻomaka ʻana o ka mālama ʻana me Presartan. Pono e hoʻoponopono i ka dehydration ma mua o ka presartan a hoʻomaka i ka mālama ʻana me kahi haʻahaʻa haʻahaʻa.

Hōʻike nā hōʻike o ka lāʻau lapaʻau e pili ana ke kaohi o ka losartan i ka plasma i nā pae o nā mea maʻi me ka cirrhosis e hoʻonui nui ʻia, no laila, ʻo nā mea maʻi me ka mōʻaukala o ka maʻi maʻa e kuhikuhi ʻia i nā haʻahaʻa haʻahaʻa o ka lāʻau.

ʻO kekahi mau lāʻau ke hopena i ka ʻōnaehana kipinapgiotensin hiki ke hoʻonui i ka urea koko a me ka serum creatinine i nā mea maʻi me ka hana renal impaired.

ʻAʻole i ʻike ʻia a excreted i ka losartan i ka umauma umauma. I ka wā e kuhikuhi ʻia ai ka presartan i ka wā lactation, pono e hoʻoholo i kahi mea e pani ai i ka hōʻuluʻulu ʻana, a i ʻole e mālama i ka mālama ʻana i nā lāʻau lapaʻau.