Ke mālama nei i ka maʻi type 2: nā manawa hou a me nā lāʻau lapaʻau hou

I ke ao holoʻokoʻa, aia kahi hoʻonui o kēlā me kēia makahiki i ka nui o ka poʻe me ka maʻi maʻi. ʻO ka ʻāpana o ka pilikia e pili i nā hiʻohiʻona meaʻai, ʻoiai he nui nā mea kāpae i hoʻokaʻawale ʻia i nā meaʻai o kēlā me kēia lā. Akā ʻaʻole wale ka meaʻai ke kumu o ka hoʻolaha ʻia o ka maʻi. ʻO kekahi kumu nui i ka maʻi maʻi o ka maʻi ʻaina he predisposition genetic - ʻo ia ka mea e ʻike ʻole ʻia ai nā kiʻekiʻe o ka nui o ke kō i hāpai ʻia i nā hua inā inā liʻiliʻi o kekahi o nā mākua i loaʻa kēia maʻi.

No ka mea ua nui loa ka nui o nā mea maʻi me ka hoʻomanawanui i ka hoʻohaʻahaʻa glucose nui, hana hou ka lāʻau lapaʻau i ka pono antidiabetic maikaʻi loa. Mālama lākou i ke ola no ka poʻe, a i ka wā e hahai ai lākou i ka mea ʻai a i ka hoʻoponopono ʻana i ke ʻano, ua hāʻawi lākou i nā koina koko i ka nui o ke kō.

Nā huaʻala o nā sulfonylureas a me nā biguanides: ka pilina o nā mea kanu holoʻokoʻa

Mai nā makahiki o 60 o ka makahiki i hala, ua hoʻomaka ka hoʻomohala mau ʻana i nā lāʻau lapaʻau no ka mālama pono o nā hilo gula koko. ʻO ka hui mua o nā lāʻau lapaʻau i hoʻohana ʻia no ka maʻi maʻi, ka mea i kōkua nui i ka poʻe, he sulfonylureas. ʻO ka maʻalahi o ka hana a nā lāʻau lapaʻau he maʻalahi - hoʻōla lākou i nā pūnaʻi o nā pancreas, kuleana no ka hana ʻana o ka insulin. ʻO ka hopena, piʻi ka hilo ʻana o ka hāmeʻa, a hoʻemi ʻia ke kō koko koko me ke ʻano maʻi type 2.

Hoʻomākaukau Sulfonylurea

ʻEkolu mau hanauna o ka sulfonylureas. Hoʻohana ʻole ʻia nā lāʻau lapaʻau mai ka hui mua i kēia mau lā, ʻoiai ʻo ka ʻoihana lāʻau lapaʻau e hoʻomau i ka hana palena o ka tolbutamide a me ka carbamide. ʻO ka Sugar-hoʻohaʻawa i ka sulfonylureas mua o ka wā o ka hoʻokaʻawale ʻana mai ka hana ʻana. Ke hoʻohana nui nei nā lāʻau lapaʻau o ka hui ʻelua a me ke kolamu i kēia manawa ma ka hoʻomaʻamaʻa lāʻau. I nā wahi he nui o Lūkia, koe wale nō ka mea i loaʻa i nā māhele āpau o nā kamaʻāina.

ʻO nā papa maʻi maʻi e pili ana i ka lua a me ke kolu o nā hanauna o ka huaʻawa o ka sulfonylurea.

ʻO ka glibenclamide kaulana loa i kūkulu ʻia, akā ua hiki i kēia lā, ʻaʻole i nalowale kona kau ʻana. ʻO kāna inoa kālepa kālepa "ma ka pepeiao" i nā mea maʻi he nui me ka maʻi mellitus:

  • Maninil
  • Betanase
  • Hoʻolālā
  • Daonil
  • Glimidstad
  • Euglucon

Mea kaulana loa ʻo Maninil, no ka mea he palapala microionized form, e hoʻoikaika ana i ka hoʻopili ʻana o ka lāʻau.

Hōʻike ʻia ka hanauna hou (ʻekolu) e kekahi lāʻau lapaʻau - glimeperide. I ʻike ʻia ma lalo o nā hōʻailona kālepa e hiki mai ana:

ʻAʻole ʻokoʻa ʻo Glimeperid mai nā lāʻau lapaʻau ma mua o ka hana o ka hana, akā ke kūpaʻa ʻoi aku ka hopena ma nā wahi haʻahaʻa haʻahaʻa, a ʻoi aku ka maikaʻi i ka poʻe maʻi.

ʻO ka pono nui o ka hoʻokūkū sulfonylurea no ka maʻi mellitus type 2

  • maikaʻi a paʻa ka hopena.
  • therapeutic latitude kiʻekiʻe - hiki iā ʻoe ke hoʻonui pinepine i ka nui me ka makaʻu ʻole i ka hoʻomālamalama,
  • maikaʻi ʻoluʻolu
  • me ka uku haʻahaʻa
  • i nā manawa nui i ʻelua lā,
  • nā maʻalahi e hiki ai i nā mea āpau antidiabetic,
  • ke loaʻa ma nā wahi kūʻai ma nā wahi mamao.

Eia nō naʻe, no ka hoʻohana pono ʻana i nā lāʻau lapaʻau a hiki i ke kolu o ka hanauna, ka mea nui e pono ai - pono nā hua a nā pancreas e hana i ka insulin i ka liʻiliʻi liʻiliʻi.

Inā ʻaʻohe hona, a laila ʻaʻohe mea kūpono e hoʻoikaika ai i ka hana o nā mokupuni o Langerhans. ʻO ka mea ʻelua e hoʻopili ai i nā poʻe maʻi me ka maʻi diabetes he hoʻemi haʻahaʻa ma hope o kekahi mau makahiki o ka hoʻohana ʻana. Ke kūleʻa nei ke kū'ē i ka hoʻomākaukau ʻana i ka sulfonylurea, e alakaʻi ana i ka piʻi o ka glucose koko. I ke hopena, pono e hoʻonui i ka maʻi i ka hoʻonaninani no ka lōʻihi a hoʻololi paha i nā papa antidiabetic ʻē aʻe.

I waena o nā biguanides - kekahi o nā lāʻau lapaʻau kaulana loa no ke ʻano maʻi type 2, ʻoiai ke hoʻohana nui nei nā metformin.

ʻO kāna pōmaikaʻi nui ka hoʻonui ʻana i ka hana a nā mea i kū i ka insulin i ka wā e hoʻomaikaʻi i ka metabolism glucose. ʻO kahi hopena, ʻoiai me ka haʻahaʻa haʻahaʻa o ka hormone, hiki i kahi hoʻohaʻahaʻa lōʻihi i ke kō koko koko hiki. Hoʻokuʻu ka Metformin i ka paona a me ka hoʻohaʻahaʻa ʻana i ka momona, he mea nui ia i nā mea maʻi obese. Hoʻohui piha ʻia ka lāʻau lapaʻau me ka kokoke o nā lāʻau antidiabetic hou loa.

Nā lāʻau lapaʻau hou hypoglycemic hou: nā pono nui

ʻO ka mea nui ka pono o ka kūleʻa i ka mālama ʻana i ka maʻi diabetes ka hiki ke mālama pono i ka pae glucose i hope o ka papaʻaina. Aia i kēia manawa o ka manawa nui i nānā ʻia ke kiʻekiʻe kiʻekiʻe o kona ala ʻana, ka mea i hoʻopilikia kino i ke ala o ka maʻi. No laila, ua hoʻomohala ʻia nā hana antidiabetic hana pōkole. No nā hui nā hui - hele hou a nateglinide.

Pili ʻia (NovoNorm) ua loaʻa kēia mau hiʻohiʻona:

  • lawe ʻia ma mua o ka ʻai ʻana - inā ʻaʻohe ʻai, laila pono ke ʻano no ka lāʻau lapaʻau.
  • hōʻemi wale ʻia ka postprandial (ma hope o ka ʻai) glycemia, me ka hoʻopono ʻole ʻana i ka pae o ka glucose i ke koko.
  • hana wikiwiki, ikaika a pōkole
  • ʻaʻole e hōʻiliʻili i ke kino, ua maʻalahi i ka hoʻoulu ʻia e nā keiki a ma ke alo o ko lākou hemahema,
  • uku haʻahaʻa - hiki i ka lehulehu.
  • nā hui lāʻau antidiabetic maʻalahi e hui pū ʻia i repaglinide,
  • He pākaha haʻahaʻa ia o nā contraindications a me nā hopena paha.

ʻO nā pōʻino nui o repaglinide ʻo ia ka hana pono ʻole me ka monotherapy. Hiki ke hoʻohana wale ʻia no nā ʻano maʻi maʻalahi o ka maʻi mellitus a i hui pū ʻia me nā lāʻau lapaʻau ʻē aʻe. Eia nō naʻe, ʻo ka hōʻiliʻili o nā mea hana loea maikaʻi loa e hoʻopiʻi i nā pono o ka hopena theragutic o ka repaglinide, e like me ka lāʻau koho mua no ka hoʻomanawanui i ka glucose.

He lāʻau hou hou no ka maʻi diabetes dapagliflozin. He ʻokoʻa nā ka hana o ke ʻano mai nā papa ʻē aʻe e pili ana i nā papa āpau. Hoʻōmi ka lāʻau i ka reabsorption o ka glucose i loko o ke keiki, e hoʻonui ana i kona excretion i loko o ka urine. A ʻo kahi hopena, hoʻemi ʻia ka glycemia a i ka loaʻa ʻole o nā polokalamu cell pancreatic kūpono. Hōʻike ʻia ma ke kālepa Lūkini ma lalo o ka inoa kālepa Forsiga.

ʻO nā hiʻohiʻona nui o dapagliflozin:

  • kahi hana maoli hou o ka hana - ʻaʻole ia e hilinaʻi ma ka moku'āina o nā mea ʻona insulin ma nā ʻāpana ʻimi a me nā mokupuni o Langerhans,
  • maikaʻi no ka hoʻomaka ʻana i ka maʻi lapaʻau,
  • ʻaʻole hoʻoulu ʻia ka hoʻohana ʻana, hiki ke hoʻohana ʻia i nā makahiki he mau makahiki me ka hoʻēmi ʻole ʻana o ka hana
  • hoʻemi ka hana o ka lāʻau i nā mea maʻi me ka hoʻonāukiuki,
  • nā kumukūʻai kiʻekiʻe
  • ʻaʻole hiki ke hoʻohui ʻia me ka diuretics, ʻoi pū hoʻi me ka furosemide,
  • me ka kiʻekiʻe o ka hemoglobin e hoʻonui i ka puʻuwai o ka hoʻopiʻi thromboembolic,
  • ʻAʻole hiki ke hoʻohana ʻia ma mua o ka maʻi diabetes type 2 i ka poʻe kahiko - ʻo ka nui o ka makahiki no ka hoʻomaka ʻana o ka ʻoihana ʻoi aku a hiki i ka 74 mau makahiki.

I kēia manawa, ma ka hoʻomaʻamaʻa ʻana, hoʻohana ʻia ʻo dapagliflozin i kahi palena palena loa, ʻoi loa i nā poʻe ʻōpio ʻaʻole makemake i ka popoki. Akā he maikaʻi maikaʻi ka lāʻau lapaʻau.

Ke lapaʻau nei ka lāʻau lapaʻau no ka maʻi maʻi i kēia manawa me ka ʻole lihuiʻanui. ʻO ka mea hou nei, hoʻohana nui ʻia nā lāʻau o kēia pūʻulu i ka hoʻomaʻamaʻa lāʻau. Ua hoʻokumu lākou iā lākou iho he mau lāʻau palekana lōʻihi e hoʻopaʻa i ka pae o ka glycemia. ʻO lākou ke kumu no ka mālama kōkua a kākoʻo pono ʻole i kahi kauoha i kēlā me kēia lā. ʻO ka hana o ka hana ka mea e hoʻoulu ai i ka ʻae ʻana o nā ʻōkuhi PPARy, e hoʻonui ai i ka ʻike ʻana i ka insulin ma nā pūpū target. ʻO kahi hopena, ʻoi aku ka hemahema o ka hormone i haku ʻia e ka pancreas he mea koʻikoʻi loa no ka hoʻomaʻamaʻa ʻana i nā pae kō.

Nā papa maʻi maʻi diabetes like 2 e pili ana i nā thiazolidinediones - roxiglitazone a pioglitazone. ^ E Ha yM. ʻO kā lākou hiʻohiʻona nui:

  • hoʻolako i hoʻokahi ʻona hoʻokahi no ka mālama ʻana i ke kō o 24 mau hola,
  • ke pale pono ʻana i nā peʻa postprandial,
  • hoʻoponopono hoʻoponopono maʻalahi - 2, 4 a 8 mg,
  • ʻaʻole i hōʻike ʻia nā hihia o ka overdose.
  • hiki ke hoʻohana i nā pākeke,
  • hoʻolaʻa haʻahaʻa
  • kūpono e like me ka lāʻau lapaʻau wale nō
  • i ka hana ʻole ʻana o kā lākou iho - ka hoʻohana ʻana i nā lāka maʻi mai kēia pūʻulu mai ia me nā mea pono ʻole,
  • pinepine i ka wā o ka hoʻōla, loaʻa ka edema.

ʻO ka makaʻala ke lawe ʻana i ka thiazolidinediones e pono e nānā i nā wahine i ka wā premenopause. ʻOiai i ka hiki ʻole o kahi pōʻai maʻamau, hoʻonāukiuki ka roxiglitazone i ka ovulation, hiki iā ia ke alakaʻi i kahi hapai i hoʻolālā ʻole ʻia, ka mea e hōʻāhewa ʻia.

ʻO nā lāʻau hou loa i ka mālamaʻana i ka maʻi diabetes type 2

Ke hoʻomau nei ka hoʻomohala mau ʻana i ka ʻimi ʻana i nā lāʻau e kōkua i ka hoʻomaikaʻi ʻana i ka maikaʻi o ke ola o nā mea maʻi me ka maʻi diabetes. I kēia mau makahiki i hala iho nei, ua puka mai nā lāʻau hou e hōʻemi i ke koko koko i ke ʻano maʻi type 2 incretinomimetics. ^ E Ha yM. ʻO ka hiʻona o kā lākou hana ka hoʻoulu ʻana a me ka hoʻolōʻihi o ka hana o ka polekeptide glucagon. He ʻōkopa ia e hoʻāla ai i ka synthesis o ka insulin i nā pā Langerhans. Ka hui pū ʻana o ka mimetin mimetin:

  • paumuaa
  • saxaglehu
  • vildagliptin,
  • linagliptin,
  • lilelip
  • alogliptin.

Kahi ʻia loa i loko o ka hoʻomaʻamaʻa makana ubiquitous. sitagliptin ma lalo o ka inoa kālepa Januvia a vildagliptin (Galvus). ^ E Ha yM. Aia kēia mau peni no ka maʻi diabetes i nā ʻano ʻehā:

  • lawa pono glycemic i loko o 24 mau hola ma hope o hoʻokahi kakahi.
  • haʻahaʻa haʻahaʻa o nā hopena maikaʻiʻole
  • ka hoʻomaikaʻi ʻana i ka maikaʻi o ke ola o nā maʻi me ka monotherapy,
  • ʻaʻole e hui pū me nā derivatives sulfonylurea a me ka insulin,
  • kūpono no ka hoʻomaka ʻana i nā lāʻau lapaʻau,
  • hoʻohui a paʻa kū hoʻi me ke hoʻohana lōʻihi ʻaʻole i manaʻo ʻia.

ʻO ka incretinomimetics nā lāʻau lapaʻau no ka mālamaʻana i ka maʻi type 2 me kahi manaʻo maikaʻi loa. Ka hana hou ʻana o ka hoʻāla ʻana o glucagon polypeptide hiki ke alakaʻi i ka kūleʻa nui i ka mālama ʻana i ka maʻi a me ka hoʻomanawanui ʻana o ka hoʻomanawanui i nā hana hoʻomehana. Hoʻohālikelike kā lākou hoʻohana ma ke kumu hoʻokahi - he kumukūʻai ʻoi aku naʻe, akā, ua komo kēia mau lāʻau i hoʻohana ʻia no nā maʻi maʻi type 2 i nā pono federal a me ka ʻāina.

Akā he aha lā e hana ʻia ai no nā poʻe maʻi e ʻike ʻole ʻia ai ka glucagon polypeptide a ʻo kona hoʻoulu ʻia ʻana ma o ka waha ʻōlelo, ʻaʻole ia e lawe mai i ka hopena i makemake ʻia? ʻO ka hōʻuluʻulu kālā hou no ka maʻi diabetes type 2 he injections o nā analogues o kēia hormone. I ka mea maoli, ʻo ia mau lāʻau like me ka incretinomimetics like, akā hoʻokele makua. Pono e lawe mau i nā peni.

Pono e hōʻike ʻia ʻaʻole i pili ia nā inikina o ka mimetin mimetin e pili ana i ka insulin, no laila, ʻaʻole i hoʻohana ʻia lākou no kona ʻano nele.

Ka hui pū ʻana o ka makua makua i ka mimetics:

  • exenatide
  • dulaglato,
  • lixisenatide
  • liraglutide (ʻike ʻia ma lalo o ka inoa kālepa kālepa "Saksenda").

ʻO ka mimetika Injetin Injection kahi tupulaga hou o nā lāʻau lapaʻau no ka hoʻoponopono ʻana i ka mana glycemic i loko o nā mea maʻi me ka maʻi non-insulin-dependant. Hoʻokomo ʻia lākou i ka subcutaneously i loko o ka ʻōpū a i ʻole ʻūhū ma ko lākou iho hoʻokahi lā i ka lā. ʻO ka maʻamau, ʻoiai i ka hoʻopiʻi ʻana i nā maʻi ākea, hiki ke hoʻokō i ka glycemia āpau. Akā, inā pono, hiki iā lākou ke hoʻohui pū me ka metformin e hoʻoikaika i ka hana i mea e nānā ai i nā cell target. Eia kekahi, ʻoi aku ka hoʻohui ʻana mai inā hoʻohui ʻia ke ʻano type i ka maʻi maʻamau i ka wā ʻōpio.

ʻO kahi haki maoli i ka mālama glycemic ka dulaglutide (Trulicity). He kānalua mimika kahi injectable kēia, akā me ka manawa lōʻihi o ka hana. He lawa ka manawa i kahi loiloi no 7 lā, a no hoʻokahi mahina, ua lawa wale ʻia he 4 inikini. I ka hui pū me kahi hana pilikino a me ka hana kino, hiki i ka dulaglutide ke alakaʻi i nā mea maʻi e alakaʻi i kahi kūlana maikaʻi loa a ʻaʻole ia e hilinaʻi i kēlā me kēia lā o nā papa papa no ka maʻi maʻamau 2. Aia he 2 mau mea e palena i ka hoʻohana ʻana i nā kaha hou aʻe - ʻaʻole nā ​​maʻi āpau i ʻae i nā injections i ka manawa e koho ai ke ʻano he ala ʻē aʻe o nā papa, a me ke kumukūʻai kiʻekiʻe hoʻi.

Hoʻohālikelike

No laila, aia i kēia manawa nā koho therapeutic no ka mālama pono ʻana i ka maʻi diabetes 2 type. He mau lāʻau lapaʻau nei mai nā hui like ʻole, a me nā lāʻau lapaʻau injectable. Ka mea akamai loea e hoʻomaopopo i nā hiʻohiʻona o ka lāʻau lapaʻau ʻenehana hou e koho maʻalahi i ka lāʻau pono no kēlā me kēia mea maʻi, me ka noʻonoʻo ʻana i kāna ʻano kūʻokoʻa. Hoʻokomo pū nā lāʻau lapaʻau no ka maʻi maʻi i ka pono a me ka ʻoluʻolu no ka mea maʻi. ʻO kekahi mau hoʻonā injectable e ʻae wale i ka hoʻomanaʻo ʻana i ka hebedoma i ka pono o nā kaʻina therapeutic.

Ke paʻa nei ka ʻike hou ʻana o nā lāʻau lapaʻau hou ʻaʻole i kūpaʻa - hana ʻia nā lāʻau pono a palekana i ka hoʻohaʻahaʻa i ke koko koko, kahi e hiki ai ke nānā aku i ka wā e hiki mai ana o nā maʻi e hoʻomohala i kahi maʻi ʻino.

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