Liptonorm - ʻōlelo aʻo pili no ka hoʻohana ʻana > He hoʻomaʻemaʻe a me ke pale aku

Ka helu helu inoa: P No. 016155/01

Trade inoa o ka lāʻau lapaʻau: Liptonorm®

Inoa Kūʻai ʻole honua: Atorvastatin

Pākuʻi helu: Nā papa hana i kala ʻia

Hōʻike

Aia i kēlā me kēia papa pākuʻi:
ʻO ke ʻano waiwai - Atorvastatin calcium, i kahi nui e like me 10 mg a me 20 mg o ka atorvastatin
Nā mea hoʻoweliweli: calcium carbonate, microcrystalline cellulose, lactose, ʻumikumamāwalu 80, hydroxypropyl cellulose, crossscarmellose, magnesium stearate, hydroxypropyl methyl cellulose, titanium dioxide, polyethylene glycol.

ʻO keʻano

Ke keʻokeʻo, nā ʻāpana polu, nā ʻoniʻoni pālua me ka pā kiʻi. Ma ka hoʻomaha, keʻokeʻo a keʻokeʻo paha nā papa.

ʻĀpana Pharmacotherapeutic: agena lipid-hamama - kahi pale o HMG CoA reductase.

AINA CODE S10AA05

ʻO nā waiwai Pharmacological

Lapaʻau lāʻau
ʻO ka maʻi Hypolipidemic mai ka pūʻulu o nā statins. ʻO ka hana nui o ka hana o ka atorvastatin ka kaohi ʻana o nā hana o ka coenzyme 3-hydroxy-3-methylglutaryl A - (HMG-CoA) reductase, he enzyme e hōʻiliʻili nei i ka huli ʻana o HMG-CoA i ka waika mevalonic. ʻO kēia hoʻololi i kekahi o nā neʻe mua i ka mekala synthesis o ke kino ma ke kino. ʻO ke kaohi ʻana o ka synthesis cholesterol atorvastatin e alakaʻi i ka hoʻonui nui o ka receptors LDL (haʻahaʻa lipoproteins haʻahaʻa) i loko o ka ate, a me nā ʻili extrahepatic. Hāʻawi kēia mau mea i ka palaka LDL a kāpae iā lākou mai ke kahe koko, ke alakaʻi nei i ka LDL cholesterol i ke koko.
ʻO ka hopena antisclerotic o ka atorvastatin he hopena o ka hopena o ka lāʻau lapaʻau ma nā paia o nā kīʻaha koko a me nā ʻike koko. Mālama ka lāʻau lapaʻau i ka hoʻohuihui ʻana o ka isoprenoids, ʻo ia nā mea ulu o nā pūpū o nā pona o nā loko o loko o nā kīʻaha koko. Ma lalo o ka hopena o ka atorvastatin, e hoʻonui ai ka hoʻonui ʻana i ka hilinaʻi o ka endothelium. Atorvastatin lowers kolesterol, lipoproteins haʻahaʻa haʻahaʻa, apolipoprotein B, triglycerides. Ke kumu o ka hoʻonui ʻana i ka cholesterol HDL (dipoproteins kiʻekiʻe kiʻekiʻe) a me ka apolipoprotein A.
ʻO ka hana o ka lāʻau lapaʻau, ma ke ʻano he kānāwai, hoʻomohala ma hope o 2 mau pule o ka hoʻokele, a me ka hopena ʻoi loa ka hopena ma hope o nā hebedoma ʻehā.

Lapaʻau lāʻau
He kiʻekiʻe nā Absorption. ʻO ka manawa e hiki ai i ka manawa kiʻekiʻe ka 1-2 mau hola, ʻo ka nui o ka manaʻo o ka wahine ma mua o 20% ʻoi aku ka kiʻekiʻe, ʻo AUC (ma lalo o ka pihi) he 10% haʻahaʻa, ʻoi ka nui o ka nui o ka nui o nā maʻi me ka cirrhosis alikaola he 16 mau manawa, ʻo AUC he 11 mau manawa ma mua o ka maʻamau. Hōʻemi ka meaʻai i ka wikiwiki a me ka lōʻihi o ka lawe ʻana mai i ka lāʻau (e 25% a me 9%, pākahi), akā me ka hoʻēmi ʻana o ka kolamu LDL e like like me ka hoʻohana ʻana o ka atorvastatin me ka ʻole o ka meaʻai. ʻO ka ʻike o ka atorvastatin i ka wā i ke ahiahi ma lalo iho o ke kakahiaka (ma kahi o 30%). Ua hōʻike ʻia kahi pilina palena ma waena o ke kūkaʻi o ka huina a me ka loaʻa ʻana o ka lāʻau lapaʻau.
Bioavailability - 14%, bioavailability o ka ʻōnaehana o ka hana pale i kūʻē i ka HMG-CoA reductase - 30%. ʻO ka bioavailability systemic haʻahaʻa ma muli o ka presystemic metabolism ma ka membous mucous o ka gastrointestinal tract a ma ka "papa mua" ma o ka puʻu.
ʻO ka hapa nui o ka hoʻoilina he 381 l, ka pilina me nā kōmela plasma o 98%.
Ka hana i ka nui ma ka ate ma lalo o ka hana a cytochrome P450 CYP3A4, CYP3A5 a me CYP3A7 me ka hoʻokumu ʻana o nā metabolite hoʻonaninani pharmacologically (ortho- a me para-hydroxylated derivatives, nā hua beta-oxidation).
ʻO ka hopena o ka hopena o ka lāʻau e kūʻē i ka HMG-CoA reductase ma kahi o 70% e hoʻoholo ana e ka hana o nā metabolites ka hele.
Hoʻohui ʻia ia i loko o ka bile ma hope o ka hepatic a / a i ʻole metabolism nui aʻe (ʻaʻole ia i loaʻa i ka enterohepatic recirculation).
ʻO ka hapalua-ola he mau hola 14. ʻO ka hana o ka pale ke kūʻē i ka HMG-CoA reductase e hoʻomau nei no kahi o 20-30 mau hola, ma muli o ka hikiʻana o nā metabolites ikaika. ʻOi ka liʻiliʻi o 2% o kahi kūpono i loko o ka waiʻai.
ʻAʻole ia i excreted i ka wā hemodialysis.

Nā hōʻailona no ka hoʻohana ʻana

ʻO ka hypercholesterolemia primale, ka hoʻohui hyperlipidemia, heterozygous a me ka homozygous hypercholesterolemia familial (ma ke ʻano he meaʻaiʻai).

Hypersensitivity o kekahi o nā mea o ka lāʻau, maʻi ʻeha ma ke ʻano ikaika (me ke ʻano hepatitis neʻe ikaika, hepatitis palaka), ua hoʻonui ʻia ka nui o nā transaminases hepatic (ʻoi aku ka 3 mau manawa i hoʻohālikelike ʻia me ka palena palena kiʻekiʻe o ka maʻamau) o ka kumu ʻike ʻole. ka huhū o ke ake (hōʻeha ʻo A a me B e like me ke ʻano o ke keiki-Pyug), ʻo ka cirrhosis o kekahi etiology, hapalua, lactation, mau makahiki a hiki i 18 mau makahiki (ʻaʻole i hoʻokū ʻia ka maikaʻi a me ka palekana).

Me ka mālama pono: ka moʻolelo o ka maʻi o ka ate, ka hōʻemi ʻana o ka electrolyte koʻikoʻi, ka endocrine a me ka hopena metabolic, ʻokēwai, hypotension arterial, maʻi pākuʻeha koʻikoʻi (sepsis), nā kuʻuna kuapo ʻole, nā hana lehulehu, nā mea hōʻeha.

ʻLoe a me ke kākele

Ma mua o ka hoʻomaka ʻana i ka mālama ʻana me Liptonorm, pono e hoʻoneʻe ʻia ka mea maʻi i kekahi meaʻai e hōʻoia ai i ka hoʻemi ʻana o nā lipid koko, pono e mālama ʻia i ka wā o ka mālama ʻana me ka lāʻau lapaʻau.
Ma loko, lawe i kēlā me kēia manawa o ka lā (akā i ka manawa like), kahi ʻole o ka pili o ka meaʻai.
ʻO ka papa ʻōlelo hoʻomaka ʻia he 10 mg hoʻokahi i ka lā. ʻO ka manawa, koho ʻia ka pākolo i kēlā me kēia ma muli o ke ʻano o ka cholesterol - LDL. Pono e hoʻololi ʻia ka ʻōlelo me kahi kekona o 4 mau hebedoma. ʻO ka dosis kiʻekiʻe loa i kēlā me kēia lā he 80 mg ma 1 pāʻai.

Hōʻike (heterozygous hereditary a polygenic) hypercholesterolemia (type IIa) a hui pū ʻia ka hyperlipidemia (type IIb)
Hoʻomaka ka hoʻomaʻamaʻa ʻana i ka dosis hoʻomaka, ʻoi aku ka nui ma hope o nā hebedoma 4 o ke ʻano maʻi, ma muli o ka pane a ka mea maʻi. ʻO ka palena kiʻekiʻe loa o kēlā me kēia lā he 80 mg.

Homozygous hoʻoilina hypercholesterolemia
Hoʻohālikelike ka laulā like me nā ʻano ʻē aʻe o ka hyperlipidemia. Kahi ʻia ka ʻōmole mua ma muli o ka nui o ka maʻi. I ka hapa nui o nā mea maʻi me ka homozygous hernaia hypercholesterolemia, ʻike ʻia ka hopena maikaʻi loa i ka wā e hoʻohana ai i ka lāʻau lapaʻau i kēlā me kēia lā o 80 mg (hoʻokahi).

I nā maʻi me ka pilikia ʻole a i nā mea maʻi ʻelemakule, ʻaʻole pono ka hoʻoponopono ʻana o ka maʻi liptonorm.
I ka poʻe maʻi me ka pīhoihoi hana ʻōmaʻomaʻo, e mālama pono ʻia ka mālama me ka hoʻolohi ʻana i ka hōʻemi o ka hōʻemi mai ke kino. Pono e nānā pono ʻia nā ʻōkola a me nā ʻōkuhi hana, a inā i ʻike ʻia nā loli pathological nui, pono e hōʻemi ʻia ka pakanā a i ʻole e hoʻokuʻu ʻia ka lāʻau lapaʻau.

Mai ka pūnaehana neʻe o waena: i ʻoi aku i ka 2% o nā hihia - ka insomnia, hōʻeha, i ka emi ma lalo o 2% o nā hihia - ka hōʻeha, ka ʻeha, ka hopena o ka ʻanuʻu, ka ʻūlū ʻana, ka hiamoe ʻana, ka pōloli, amnesia, paresthesia, nā maʻi peripheral, amnesia, nā hana naʻau, nā hanaxia, ka palaka ʻana o nā maka, ka hyperkinesis, ke kaumaha. hyperesthesia, lilo ka ʻike.
Mai nā ʻike: amblyopia, ke kani ana o ka pepeiao, ka maloo o ka conjunctiva, kahi haunaele o ka noho ʻana, hemorrhage ma nā maka, kamaʻāina, glaucoma, parosmia, nalowale o ka ʻono, hoʻoweliweli o nā ʻono.
Mai ka pūnaehana cardiovascular: ma mua o 2% mau hihia - umauma ʻeha, ma lalo o 2% - palpitations, vasodilation, migraines, postural hypotension, piʻi koko nui, phlebitis, arrhythmia, angina pectoris.
Mai ka ʻōnaehana hemopoietic: anemia, lymphadenopathy, thrombocytopenia.
Mai ka papa hana hanu: i ma mua o 2% mau hihia - bronchitis, rhinitis, ma lalo o 2% mau hihia - pneumonia, dyspnea, bronchial asthma, nosebleeds.
Mai ka pūnaehana hana ʻana: i loko o ka 2% o nā hihia - ka nausea, ka ʻōpū, ka constipation a i nā maʻi paha, ka lemulewa, ka gastralgia, ka ʻeha o ka ʻōpū, anorexia a i ʻole ka nui ʻana o ka makemake, ka waha maloʻo, belching, dysphagia, ka luaʻi, stomatitis, esophagitis, glossitis, erosive a me nā ulcerative lesi o ka mucous membrane o ka lua. waha, gastroenteritis, hepatitis, colic hepatic, cheilitis, ulia duodenal, pancreatitis, cholestatic jaundice, hana 'aho ka pale, ʻeka lula, melena, nā kahe koko, tenesmus.
Mai ka ʻōnaehana musculoskeletal: i ʻoi aku i 2% o nā hihia - ka lāʻau'ōwili, ma lalo o ka 2% o nā hihia - nā puʻupuʻu wāwae, bursitis, tendosynovitis, myositis, myopathy, arthralgia, myalgia, rhabdomyolysis, torticollis, hypertonicity o ka'ōpū, hui pū kekahi.
Mai ka pae genitourinary: i ʻoi aku i ka 2% o nā hihia - nā maʻi urogenital, edema peripheral, ma ka liʻiliʻi o 2% o nā hihia - dysuria (me ka pollakiuria, nocturia, ka maʻi urinary a me ka hoʻomau ʻana paha i ka urinary, mandatory urination), nephritis, hematuria, vaginalugo, nephrourolithiasis, metrorrhagia, epididymitis, hoʻemi i ka libido, ka hemahema, ka mana ejaculation.
Ma ka ʻāpana o ka ʻili. emi ma mua o 2% mau hihia - alopecia, xeroderma, hoʻonui nui ʻia, eczema, seborrhea, ecchymosis, petechiae.
Nā maʻi kūwaha: a emi mai ka 2% o nā hihia - ka hanaʻeha, ka ʻehaʻeha o ke kino, kahi dermatitis, ʻike pinepine ʻole - urticaria, angioedema, facema edema, photosensitivity, anaphylaxis, erythema multiforme, sindrom Stevens-Johnson, nāʻino o ka eprimasis epidermal (ʻelllelo o Lyell).
Nā hōʻailona hana Laboratory: emi ma mua o 2% o nā hihia he hyperglycemia, hypoglycemia, kahi piʻi i ka serum creatine phosphokinase, alkaline phosphatase, albuminuria, he piʻi nui o ka alanine aminotransferase (ALT) a i ʻole assartic aminotransferase.
Nā ʻili: emi ma mua o 2% mau hihia - loaʻa ka momona, gynecomastia, mastodynia, exacerbation o gout.

Ke keu

Lāʻau: ʻAʻohe mea antidote kikoʻī. Hoʻomaka ʻia ke ʻano maʻi Symptomatic. Hana lākou i nā hana e mālama i nā hana koʻikoʻi o ke kino a me nā mea e pale ai i ka hoʻopili hou ʻana o ka lāʻau lapaʻau: lavage gastric, intake o ka ulana i hoʻōla ʻia. ʻAʻohe huakino ka Hemodialysis.
Inā aia nā hōʻailona a me ka hele ʻana o nā mea e pili ana i ka hoʻomohala ʻana o ka hana ʻole i ka aʻalolo ma muli o ka rhabdomyolysis (kahi hopena koʻikoʻi akā paʻakikī), pono e hoʻokuʻu koke ʻia ka lāʻau lapaʻau.
No ka pili nui i ka atorvastatin me nā protein plasma, ʻo ka hemodialysis he ala maikaʻi ʻole e wehe i kēia mau mea mai ke kino.

Hoʻopili pū me nā lāʻau ʻē aʻe

Me ka hoʻokūkū pū ʻana o ka cyclosporine, fibrates, erythromycin, clarithromycin, immunosuppressive, antifungal lāʻau (e pili ana i ka azoles) a me ka nicotinamide, ke piʻi ʻana o ka ʻike o ka atorvastatin i loko o ke koko koko (a me ka loaʻa o ka pilikia o ka myopathy). Hoʻomau nā antacids i ka hoʻouluʻana e 35% (ʻaʻole i loli ka hopena ma ka LDL cholesterol).
ʻO ka hoʻohana like ʻana o ka atorvastatin me nā protease inhibitors i ʻike ʻia ka cytochrome P450 CYP3A4 inhibitors i hoʻohui pū ʻia e ka hoʻonui o ka hiki ʻana o ka plasma o atorvastatin.
I ka hoʻohana ʻana i ka digoxin i hui pū me ka atorvastatin ma kahi maʻa o 80 mg / lā, hoʻonui ʻia ka ʻike o ka digoxin ma kahi o 20%.
Hoʻonui i ka neʻe ma o 20% (i ka manawa i kuhikuhi ʻia me ka atorvastatin ma kahi ma 80 mg / lā) o nā mea hoʻohālikelike waha e loaʻa ana i ka norethindrone a me ka ethinyl estradiol.
ʻOi aku ka hopena lipid-haʻahaʻa o ka hui me ka colestipol ma mua o kēlā me kēia lāʻau lapaʻau hoʻokahi.
Me ka hoʻokūkū like me warfarin, emi ka manawa prothrombin i nā lā mua, akā naʻe, ma hope o 15 lā, e hoʻomaʻamaʻa kēia hōʻailona. I kēia mea, ʻike ka poʻe maʻi e lawe ana i ka atorvastatin me ka warfarin i kahi ma mua o ka manawa e mālama i ka manawa prothrombin.
ʻO ka hoʻohanaʻana i ka wai pānaʻi i ka wā o ka mālama ʻana me ka atorvastatin hiki ke alakaʻi i ka hoʻonui ʻana o ka ʻai i ka lāʻau i loko o ke koko koko. Ma kēia hana, pono i nā mea maʻi e lawe i ka lāʻau e pale i ka inu ʻana i kēia wai.

Nā ʻōlelo kikoʻī

Hōʻeha ka hana ʻoluʻolu
ʻO ka hoʻohana ʻana o HMG-CoA reductase inhibitors e hoʻohaʻahaʻa i nā lipids koko e hiki ke alakaʻi i kahi hoʻololi i nā ʻōhua biochemical e hōʻike ana i ka hana ate.
Pono ka nānā ʻana o ka naʻau ma mua o ka mālama ʻana, 6 hebedoma, 12 mau pule ma hope o ka hoʻomaka ʻana iā Liptonorm a ma hope o kēlā me kēia nui e hoʻonui, a me kēlā me kēia manawa, no ka 6 mau mahina. ʻO ka hoʻololi ʻana i ka hana o nā hoʻouka o ke ʻina e ʻike ʻia ma nā malama ʻekolu ma hope o ka hoʻomaka ʻana o ka lawe ʻana iā Liptonorm. ʻO nā mea maʻi me ka piʻi o nā kiʻekiʻe transaminase pono e nānā pono a hiki i ka pae o ka enzyme e hoʻi i ka maʻamau. Ma ka hanana i loaʻa nā waiwai o alanine aminotransferase (ALT) a i ʻole aspartic aminotransferase (AST) iʻoi aku ma mua o 3 mau manawa i ka nui o ka palena o ka palena o luna, a manaʻo ʻia e hōʻemi ana i ka hopena o Liptonorm a i ʻole hana i ka mālama ʻana.

He huika ʻili kāwili
ʻO ka poʻe maʻi me ka diffuse myalgia, lethargy a i ʻole nā palupalu a me / a me ka hoʻonui nui ʻana i ka KFK e hōʻike ana i kahi puʻuwai no ka hoʻomohala ʻana i ka myopathy (i wehewehe ʻia ʻo ka ʻeha o ka naʻau me ka piʻi ʻana i loko o KFK ma mua o 10 mau manawa i hoʻohālikelike ʻia me ka palena o luna o ke maʻamau).
I ka koho ʻana i ka hui hoʻohui ʻana o Liptonorm me ka cyclosporine, ka honu o ka aila fibric, erythromycin, clarithromycin, immunosuppressants, a me nā lāʻau antifungal o ke ʻano azole, me nā koina o ka niacin e hōʻemi ai i ka pae lipid, pono ke hoʻohālikelike i nā pōmaikaʻi e pili ana i ka hōʻeha a me ke kūlohelohe i nā mea maʻi. nona nā hōʻailona a hōʻailona paha o ka hōʻeha o ka ʻāʻī, ka lethargy a i ʻole nā waliwali e ʻike, ʻoi loa ia i nā mahina mua o ka mālama ʻana a me ka piʻi ʻana o ka maʻi o kekahi Reparata.

Pono e hoʻokaʻawale a hoʻomaha paha ke ʻano me ka Liptonorm inā loaʻa kahi maʻi koʻikoʻi e hopena mai ka myopathy, a inā he pilikia koʻikoʻi no ka hoʻomohala ʻana i ka hana ʻōiwi pale ma muli o ka rhabdomyolysis (e. nā metabolic a me ka hopena endocrine, a me ka hoʻopalike ʻana o ka electrolyte).
I nā wahine o nā makahiki hānau o ka hoʻohana ʻole i ka hoʻohana i ka hoʻomāliʻiliʻi mau, ʻaʻole i ʻōlelo ʻia ka hoʻohana ʻana o Liptonorm. Inā hoʻolālā ka mea maʻi i ka hapai, pono ia e kāpae i ka lawe ʻana iā Liptonorm ma kahi o hoʻokahi mahina ma mua o ka hapai i hoʻolālā ʻia.
Pono e nīnau aku ka mea maʻi i ke kauka inā loaʻa ʻole nā hemahema a me ka nāwaliwali o ka naʻau, ʻoiai inā hele pū lākou me ka malaise a me ka ʻala.

Hoʻokomo i ka hiki ke alakaʻi i kahi kaʻa a hana pū me nā mīkini

ʻO ka hopena ʻino o Liptonorm ma luna o ke hiki ke lawe i kahi kaʻa a hana pū me nā hana e koi ai i ka nui o ka makaʻala.

E hoʻokuʻu i ke ʻano

Nā papa papa ʻala a 10 a 20 mg.
Ma 7, 10 a he 14 paha papa i nā blru Al / PVC.
1, 2, 3, 4 mau laka ma kahi kāwele kāleka me nā kauoha no ka hoʻohana ʻana.

Nā kūlana mālama

Papa inoa B. I kahi maloʻo malū a maloʻo ma lalo o 25 ° C.
Mai mālama i nā keiki.

ʻO ka lā kau

2 makahiki Mai hoʻohana ma hope o ka lā pau pau i hōʻike ʻia ma ka pahu.

Hoʻohui Kūʻai Kūʻai

Mea hana:
"M.J. Biopharm", India
113 Nā Lūlū Aupuni Jolly-II, Nariman Point, Mumbai 400021, India
Tel: 91-22-202-0644 Fax: 91-22-204-8030 / 31

ʻO ka mākaʻikaʻi ma ka Russian Federation
119334 Lūkia, Moscow, ul. Kosygina, 15 (GC Orlyonok), keʻena 830-832

Hoʻopeke:
Kalaiole - Leksredstva OJSC
305022, Lusia, Kursk, ul. 2nd Aggregate, 1a / 18.
Tel / Fax: (07122) 6-14-65

Hōʻike, hoʻokuʻu i ke ʻano

ʻO ka hana ikaika o Liptonorm ʻo ia atorvastatin. ^ E Ha yM. Hoʻohui ʻia ia me nā mea kōkua: calcium carbonate, cellulose, gula waiʻa, hydroxypropyl cellulose, croscarmellose, magnesium stearate, titanium dioxide, polyethylene glycol.

ʻO ka ʻāpana keʻokeʻo ke keʻokeʻo a poepoe, keʻokeʻo keʻokeʻo. Aia he mau loli like ole o ka lāʻau me kahi mea e hoʻōla ikaika o 10 a 20 mg.

Ka hana lāʻau lapaʻau

ʻO Atorvastatin he HMG-CoA reductase inhibitor. Pono kēia enzyme no ke kino e hoʻopili i ka kolamu. ʻO ka molekole ʻo Liptonorm e like me ke kāpili i ia. Lawe ʻia nā pūleo naʻau no kahi hāmeʻe, e komo i loko o ka hopena o ka hoʻomohala o ka kolamu - paʻa ia. Ma hope o nā mea āpau, ʻaʻole like ka waiwai o ka atorvastatin i ka HMG-CoA reductase.

Ke hāʻule nei ke kiʻekiʻe o ka cholesterol. Ke uku nei no kona hemahema, hoʻomaka ke kino e uhai i nā molekue e pili ana i ka LDL, e alakaʻi ana i kahi hoʻoemi o ko lākou hoʻokalakupua. ʻO ke kumuwaiwai hou o ka cholesterol he peripheral tissue. Ke halihali i ka sterol, pono "lipia" lipoproteins kiʻekiʻe e koi ʻia. Wahi a kēia, e ulu ana kā lākou helu.

Hōʻemi i ka kolamu nui, LDL, triglycerides e hoʻolōʻihi i ka holomua o ka atherosclerosis. ʻO ka mea nui i nā momona o ka momona metabolism ka mea hiki ke hōʻiliʻili i luna o ka ili o ke koko. Ke lilo ka hoʻoiho ʻana, ma ka ʻāpana a hoʻopuni piha paha i ka lumen o ka moku. Hoʻokomo ʻia ʻo Atherosclerosis o nā kīʻaha puʻuwai e hōʻeha i ka puʻuwai puʻuwai, ka puʻuwai o ka puʻuwai, nā umauma - ke kumu o nā ʻīlio trophic, wāwae necrosis.

Hoʻemi ʻia ka maikaʻi o ka atorvastatin i zero inā ʻaʻole kekahi kanaka i ʻai i kahi meaʻai e kuhikuhi ana i ka hoʻohaʻahaʻa i ka cholesterol. ʻAʻole lilo ke kino i kāna mau waiwai ponoi e uhi i ka nele o ka sterol, no ka mea mai ka meaʻai.

Hoʻomaka nā pae kiʻekiʻe i ka kolamu ma hope o 2 mau pule mai ka hoʻomaka ʻana o ka lawe ʻana i nā pōpoki. Loaʻa ka hopena kiʻekiʻe ma hope o 4 hebedoma.

Hoʻopili ʻia nā mea hoʻihoʻi Atorvastatin i loko o ka bile, ka mea i hoʻoili ʻia e ka ate. Me ka pohō ʻana o ke kino, hoʻolōʻihi ʻia kēia kaʻina. No laila, me nā pathologies ate, ua kuhikuhi pono ʻia ka lāʻau lapaʻau.

Liptonorm: mau hōʻailona no ka hoʻohana ʻana

Wahi a nā ʻōlelo kuhikuhi no ka hoʻohana ʻana o Liptonorm, ua kuhikuhi ʻia ka lāʻau lapaʻau i ka hoʻohui ʻana i ka lāʻau mālamaʻai no:

hypercholesterolemia maʻamau,
huiʻikepili hui ʻia,
heterozygous a homozygous familial hypercholesterolemia ma ka hoʻohui ʻana i ka lāʻauʻai meaʻai,

Hoʻohana ka hoʻohana ʻana o ka atorvastatin e hōʻemi i ka hopena o ka hōʻeha ʻana, ka hōʻemi ʻana o ka naʻau i nā mea maʻi me ka maʻi naʻau coronary. Eia kekahi, ʻo nā mea maʻi e lawe nei i ka liptonorm e liʻiliʻi pinepine i ka shunting, stenting, hospitalization me nā pilikia cardiovascular.

Pae kumu noi, dosage

Ma mua o ka hoʻomaka ʻana i ka mālama ʻana me Liptonorm, a ma ka papa o ke ao, pono e hele mai ka mea maʻi i kekahi meaʻai.

Hoʻopau ʻia nā papa i hoʻokahi manawa / lā, ʻaʻohe mea e pili ana i ka meaʻai, akā mau ka manawa like. ʻO ka hoʻomaka ʻana ke neʻe i ka 10 mg. Eia kekahi, koho ʻia ka wana i kū hoʻokahi, me ka nānā ʻana i ka dinamics o nā loli i ka kolamu, LDL. Hoʻololi ʻia ka hoʻoponopono ʻia ʻana ma kahi kekena ma mua o 1 mau manawa / 4 mau pule. ʻO ka dosage kiʻekiʻe e ʻae ʻia he 80 mg. Me kahi nāwaliwali nawaliwali o ke kino e lawe i ka atorvastatin, ua kuhikuhi ʻia ka mea maʻi i kahi statin ikaika a i ʻole hoʻohui ʻia me nā lāʻau lapaʻau ʻē aʻe e hoʻohaʻahaʻa i ka kolamu (sequestrants o nā kumua bile, nā inhibitor absorption cholesterol).

Me ka nele o ka ate, pono o ke koho ʻana iā Liptonorm me ka nānā ʻana i ka hana o ke kino. Inā nui lākou i kahi kīnā, ua kāpae ʻia ka lāʻau lapaʻau a kuhikuhi ʻia kahi papa hōʻemi.

Nā hiʻohiʻona, nā hopena pili

Ua hoʻonoho ʻia ka liptonorm i nā poʻe e pili ana i ka atorvastatin, lactose, kekahi mea o ka lāʻau lapaʻau a i ʻole analogue. Hoʻolaha nā papa i:

maʻi maʻi maʻi ʻeha
hoʻonui i ALT, GGT, AST e ʻoi aku ma mua o 3 mau manawa,
nā maʻi ʻeha loa
maʻiʻeha
keiki malalo o 18 makahiki.

ʻAʻole i kuhikuhi ʻia ʻo Liptonorm no nā makuahine e ʻāpono ana, nā wahine hānai. Inā hoʻolālā ʻia ka ʻāhewa ʻana, e pau ka lāʻau lapaʻau ma ka liʻiliʻi ma mua o hoʻokahi lā. Me kahi wahine hapaha ʻole i hoʻolālā ʻia, pono ʻoe e hoʻōki i ka lawe ʻana i ka lāʻau, a laila e nīnau koke i ke kauka. E kamaʻilio lākou e pili ana i ka hiki ʻana mai i ka pūpū, a hōʻike pū hoʻi i nā koho no ka hana.

Hoʻomaopopo ka hapanui o nā maʻi i ka lāʻau. ʻO ka hopena o ka hopena, inā he ʻoluʻolu, a nalo aʻe ma hope o ka manawa pōkole. Akā ʻoi paha kahi liʻiliʻi o ka hoʻolālāʻana o nā hanana.

Hoʻomaopopo ka ʻōlelo aʻo Liptonorm i nā hopena like ʻole:

Pūnaehana maʻi: pinepine nā palaualelo, dizziness, lohi i ka hōʻeha, ka malaise, ka nalowale, nā poʻomanaʻo, nā amnesia, i hoʻemi ʻia / piʻi nui ka naʻau, ka maʻi peripheral, outbursts kūloko, ka hoʻopuka lūlū, ʻeha hopohopo, ka nalowale o ka ʻike.
Nā hui pilikino: ʻike papalua, ke kani pepeiao, nā maka maloʻo, ke kuli, ka huapalapala, ka hoʻāʻo ʻana.
Pūnaehana Cardiovascular: pinepine - ka ʻeha ʻeha, ʻaʻole migraine, palpitations, hypotension a hypertension, arrhythmia, angina pectoris, phlebitis.
Pūnaehana respiratory: pinepine - bronchitis, rhinitis, jarang - nā wahi maʻi, ke kaukau bronchial, nosebleeds.
Pūnaehana Digestive: nausea, heartburn, constipation or diarrhea, ʻeha ʻeha, ka hau, anorexia a i ʻole ka nui ʻana o ka makemake, ka waha maloʻo, belching, ka lawaiʻa ʻana, hoʻopuka, ivatitis, ʻeha o ka esophagus, alana, gastroenteritis, hepatitis, colic hepatic, ulia duodenal. , pancreatitis, jaundice, haina lawelawe leʻaheʻe, hoʻāwi polū, koko māla.
Pūnaehana musculoskeletal: pinepine - ka maʻi palupalu, liʻiliʻi ʻole - nā ʻōpū o nā wāwae wāwae, bursitis, ka hōʻeha pū ʻana, myositis, myopathy, myalgia, rhabdomyolysis, hoʻonui i ka leo o ka mākala.
Pūnaehana genitourinary: pinepine - ka maʻi genitourinary, peripheral edema, līpoki - dysuria, ʻeha ʻana o ka ʻōpū, haʻi ʻana o ka ʻōpū, ka hoʻoweliweli ʻana o nā ʻatikala o nā hoʻokolohua, hoʻemi i ka libido, ka hemahema, ka mana o ka ejaculation.
ʻIli: alopecia, hoʻonui nui loa, eczema, dandruff, spot hemorrhage.
Nā maʻi kūloko: kahelehele ʻana, ka wikiwiki, ka dermatitis, urticaria, ke ʻano hypersensitivity, photosensitivity, anaphylaxis.
Nā hōʻailona mākaʻina limahana: kiʻekiʻe / haʻahaʻa haʻahaʻa, hoʻonui CPK, alkatine phosphatase, ALT, AST, GGT, anemia, thrombocytopenia.
ʻO nā mea'ē aʻe: loaʻa ka kaumaha, gynecomastia, exacerbation o gout.

I ka manawa pinepine, nā mea inu, inu ʻemi, nā mea maʻi me ka maʻi diabetes, ka ʻole o ka thyroid, nā maʻi o ka naʻau, a me ka maʻi hypotension.

E hoʻokau aku i nā liptonorm, a hui pū aku me kāu kauka inā:

hōʻeha ʻeha ʻole naʻau ʻole a ʻike ʻole,
hoʻonui ka ʻai
nahoa.

Hoʻohui

Hiki ke ʻano o ka lāʻau lapaʻau me nā lāʻau lapaʻau penei:

ʻehā (omeprazole, almagel),
kāmakua
kekehene, na huahuʻula,
nā mea pale o protease
kekahi mau ʻōlelo hoʻohālikelike waha
nā huaʻai
warfarin
itraconazole, ketoconazole.

ʻAʻole kūʻai ʻia ka lāʻau lapaʻau e nā lāʻau lapaʻau ma Lūkini. Ua hoʻopau ʻo ia i ka palapala hoʻopaʻa inoa. ʻO ke kumu kūʻai o Liptonorm i ka manawa o ka nalowale mai ke kūʻai aku he 284 mau rubles no ka 10 mg pākeke, 459 mau rubles no 20 mg.

ʻAʻole pilikia ka nele o nā lāʻau lapaʻau Liptonorm. Aia he nui nā kuʻikahi o ka lāʻau me ke ʻano like. Hiki iā ʻoe ke noi i nā lāʻau lapaʻau:

Nā mea kokoke
Anvistat
Atomax
Ator
Tulip
Atorvastitin-OBL,
Kauwe
Kauweh
Hanaa Avexima,
Atorvox
Kāleka
Lipoford
Liprimar
Novostat,
Kauka
Torvalip
Torvacard
Kauka.

Ma kahi o nā lāʻau lapaʻau i luna aʻe, hiki iā ʻoe ke ʻohi i nā analogie Liptonorm e ka ʻoi ʻana o ka hana:

simvastatin - 144-346 rubles.,
lovastatin - 233-475 rubles.,
rosuvastatin - 324-913 rub.,
flvastatin - 2100-3221 rub.

Aia nā mākeke a pau i ka ʻāpana o ka hana, akā ua kau ʻia nā mea āpau o lākou. No laila, e kamaʻilio mau i kāu kauka ma mua o ka hoʻololi ʻana i ka lāʻau.

Nā mea i hoʻomākaukau ʻia e nā mea kākau o ka papahana
mamuli o ka palia hoʻoponopono o ke kahua.

E hoʻokuʻu i ke ʻano a me ka ʻano

Loaʻa ka Liptonorm i ke ʻano o nā papa: pani ʻia me ka ʻulaʻula keʻokeʻo, hoʻopuni, biconvex, ma ka wā i ka wā - keʻokeʻo a ʻehā paha hoʻi (14 pcs. I nā palaha, 2 mau kihila i loko o ka pūlima pepa).

ʻO ka mea ikaika o ka lāʻau ka atorvastatin (ma ke ʻano o ka paʻakai kalima). I ka papa papa 1 he mau mea a 10 a 20 mg paha.

Nā mea kūʻokoʻa: crosscarmelose, hydroxypropyl cellulose, magnesium stearate, ʻumikumamāwalu 80, lactose, hydroxypropyl methyl cellulose, microcrystalline cellulose, titanium dioxide, calcium carbonate, polyethylene glycol.

Hoʻomili hou a me ke ʻano hoʻohālikelike

ʻO ka hana nui o ka Liptonorm ʻo Atorvastatin calcium trihydrate ma ke ʻano o ka paʻakai kalaiwa. I waena o kāna mau mea kōkua?

kalaka
Xa 80,
MCC
ʻai hou nā meaʻai E463 a me E572,
sodium polio
lactose
wai maʻemaʻe.

Hoʻokumu ʻia ka Liptonorm ma ke ʻano papa. Aia nā papa i 10 a i ʻole 20 mg i loaʻa i ka nui o 7, 10, 14, 20, 28 a 30 mau pcs.

Nā hōʻailona no ka hoʻohana ʻana

Ua kuhikuhi ʻia ka lāʻau lapaʻau no ka hoʻonui ʻana i ka cholesterol. Hoʻokō ʻia kāna hana i ka pale ʻana i ka ʻōlelo lipid ma ke koko. Pono e hoʻohana ʻia ka liptonorm ma ka pauku i kuhikuhi ʻia e ke kauka.

ʻO ka Liptonorm lāʻau lapaʻau he ākea ākea o ka hana. He hopena ka lāʻau i ka lipid-hoʻohaʻahaʻa a me ka hopena anti-atherosclerotic. ʻO ka hopena lipid-hoʻohaʻahaʻa i ka lāʻau liptonorm ka mea o kāna hana ikaika e hana i ka pale ʻana o ka kolamu a me ka hoʻopau ʻana i nā palaka LDL mai ka plasma koko.

ʻO ka hopena anti-atherosclerotic e hoʻokumu ana i ka mea hiki i ka lāʻau lapaʻau ke pale i ka ulu o nā nui i loko o nā kīʻaha koko a hoʻohaʻahaʻa i nā ʻike o nā māhele lipid koko. Ma muli o ka laulā ākea o ka hana, pono ke kuhikuhi ʻia ka lāʻau lapaʻau no nā maʻi aʻe.

predisposition genetic i ka nui lipid mea,
kūlia
hetero - a i ʻole ʻano homozygous o ka familial type hypercholesterolemia.

ʻAʻole pono e hilahila ʻia ka liptonorm me ka lāʻau lapaʻau no ka mea momona kaumaha ʻo Liponorm. ʻO kaʻoi aʻe o ka mea o ka mea i ka papaʻai, he kūʻai ʻia wale nō i nā capsules.

Nā hopena hopena

Inā noʻonoʻo ʻole ka mea maʻi i ka contraindications a i ʻole eʻoi aku i ka nui o ka nui o nā papa i kuhikuhi ʻia, e pili ʻo ia i ka loaʻa ʻana o nā hopena ʻaoʻao. ʻO ka hoʻokomo ʻole ʻana i nā lula o ka pono o ka maʻi hiki ke kumu nā ʻōnaehana a me nā ʻāpana:

CNS ʻO ka hōʻike nui ʻana o kahi pōʻino o ka wahī mea hoʻonāukiuki a me ke ʻano hiamoe. Ma nā hihia kaʻawale, ʻike ka poʻe maʻi i nā hōʻailona e like me ka moemoeā, asthenia, ataxia, paresis a me hyperesthesia, e alakaʻi ana i ka manawa lōʻihi.
Nā hui ʻōpū. ʻO nā hōʻailona o ka neʻe ʻana o kā lākou hana e manaʻo ʻia he hemorrhage i loko o ka eyeball, nele i nā kohu conjunctival, nele o kekahi mau manaʻo ʻole i ka wā e ʻai ana, ka nalowale o ka hiki ke ʻike i nā ʻoni.
ʻŌnaehana genitourinary. ʻO nā maʻi urological a me nā puʻuwai, nā pilikia urination, ka hoʻomohala ʻana o ka hana ʻole o ka pilikia ʻole i ka wā o ka mālama ʻana i nā maʻi, hoʻemi ka potency ʻo ia ka hopena maʻamau loa i ka wā o ka mālama ʻana me Liptonorm.
ʻŌnaehana limahana. ^ E Ha yM. Hiki i kahi papa lāʻau lapaʻau ke hoʻonāukiuki i ka hoʻomohala ʻana o nā maʻi koko - lymphadenopathy, anemia a i ʻole thrombocytopenia.
ʻĀpelu kikowaena. ʻO ka mālama ʻole ʻole i nā lula ma muli o nā papa e like me nā ʻōkuhi e alakaʻi i ka hoʻomohala o nā maʻi o ka pēpē a me ka puʻuwai, ka mea i hōʻike ʻia e ka pua, rumbling, vomiting reflex, hepatic colic, a me ka hepatitis hoʻi.
ʻŌnaehana Cardiovascular. Hiki i ka poʻe maʻi ke loaʻa i ka hypertension arterial, angina pectoris, hoʻoulu ʻia o ka umauma.
ʻŌnaehana Integumentary. Hiki i nā dermatological a i ʻole nā hopena pakanikeka ke komo i ka rashes, itching, seborrhea, eczema, jarang urticaria a i ʻole anaphylactic shock.

Nā ʻōkuhi no ka hoʻohana

ʻO Liptonorm kahi ʻelele o ka hui o nā lāʻau lapaʻau i hoʻohana ʻia ma ka mālama ʻana i ke kiʻekiʻe o ka palaki lipid. Atorvastatin - ka hiʻona neʻe ikaika, he ikaika lipid-hoʻohaʻahaʻa ia, ʻo ia hoʻi, e kōkua i ka hoʻemi ʻana i nā lipid moe ma loko o ke koko. Hoʻopili ʻia kona mea i loko o ke koko ma hope o kahi 1 hola ma hope o ka noi. I ke kakahiaka, ʻo kēia helu he 30% kiʻekiʻe loa i ke ahiahi.

ʻO ka hopena mai ka hoʻohana ʻana o statins i nānā ma hope o 14 mau lā. Loaʻa ka hopena kiʻekiʻe loa ma hope o 1 mahina o ka hoʻohana ʻana.

ʻO ka lawe ʻana i ka lāʻau lapaʻau, ʻaʻole ia e hilinaʻi i ka hoʻokomo o ka meaʻai i loko o ke kino. ʻO ke kūlana wale nō e loaʻa i ka hopena o ka hoʻohana ʻana i ka lāʻau lapaʻau, ʻo ka hoʻohana ʻana o kēlā me kēia lā nā papa i ka manawa like. Pono ka mea maʻi e ʻoi aku i ka maʻamau - 10 mg i kēlā me kēia lā. Ke puka nei i kēlā me kēia lā i hiki ke hana ʻino i ka olakino a hoʻonāukiuki i nā ʻano kūpono ʻole.

Ma mua o ka hoʻomaka ʻana i nā maʻi, pono e nānā nā kauka i ka hana ate. Manaʻo nā mea hōʻike i ke akahele a hele pinepine aku i ke kauka e nānā i ka hana o ka ate no nā mahina 3 mua ma hope o ka hoʻomaka ʻana o ka mālama ʻana. Hiki i ka hoʻoponopono ʻia o nā pila ma loko o nā hebedoma ma hope o ka hoʻomaka ʻana o ka mālama ʻana, akā ʻaʻole ʻoi mau pinepine ma mua o ka manawa 1 ka mahina. I ka wā e hoʻokae ai, pono i nā kauka i kēlā me 6 mahina. ka hoʻololi ʻana i ka hoʻololi o ka pale ʻana enima.

Wahi a nā kūlana o ka hoʻohana ʻana, pono e mālama nā papa i kahi wahi anu. Hōʻike ʻia nā hōʻailona ʻokoʻa i loko o kēia lumi +25 degere.

Hoʻohana i ka wā hāpai

Lā ia ke ʻano ikaika o ka lāʻau lapaʻau no ka poʻe maʻi i ka wā hāpai a ʻo ka wā lactation (ka umauma o ka maʻi) ma muli o ka hopena maikaʻi loa o ke kino o kahi pēpē. Inā hoʻolālā paha ka mea maʻi i ka hapai, ʻoi aku ka maikaʻi o ka haʻalele iā ia i mau mahina. ʻO ka wahine i ka wā o ka mālama ʻana me Liptonorm, ʻaʻole pono e haʻalele i ka hemahema.

ʻO nā maʻi ʻē aʻe e pili ana i ka wā kamaliʻi a me nā ʻōpio. ʻAʻole ʻike ka ʻike e pili ana i ka mālama ʻana o nā keiki me ka lāʻau lapaʻau a hiki i kēia manawa.

Ka lāʻau kūʻai lāʻau

ʻO ke kumukūʻai o ka lālani Liptonorm e hoʻoholo ʻia e kekahi mau kumumanaʻo - ka nui o nā blisters i ka pālākiō, dosage, etc. I ka awelika, hiki ke kūʻai ʻia nā papa he 10 mg ma kahi lāʻau kūʻai no ka 200-250 rubles. ʻO ke kumu kūʻai o kahi paila he 28 pcs. 20 mg i kēlā me kēia he 400-500 rubles.

I Ukraine, ʻo ke kumukūʻai o kahi lāʻau lapaʻau ma loko o kahi pahu lāʻau o 20 mg ʻo 250-400 UAH.

Nā kikowaena liptonorm

ʻOiai ʻo ka liptonorm kahi lāʻau maikaʻi loa, ʻaʻole kūpono ia i nā maʻi āpau. ʻO ka hypersensitivity i kekahi hapa o ka lāʻau a me ka overpriced ʻelua kumu kumu nui no ka hoʻopili ʻana iā ia me ke ʻano kumu kūʻai haʻahaʻa.

Aia nā lāʻau lapaʻau e like me nā mea hoʻohālikelike o Liptonorm:

Nā Hōʻike Hoʻohana

Hōʻike nā hōʻike i kona hoʻohana ʻana i nā kauka i kuhikuhi pinepine i ka lāʻau lapaʻau i ka mea maʻi me nā wehewehe kiko ʻole e pili ana i nā hiʻohiʻona o kona hoʻokele a me nā hopena kūpono paha.

Tamara, Moscow: "I nā lā mua ma hope o ka lawe ʻana i nā pōpoki, ua hoʻomaka wau i ka hōʻeha ʻana i loko o kuʻu ʻōpū, a laila ʻāhū wau i loko o koʻu ʻōpū, a i kekahi mau lā ma hope - ua maʻi a me ka luaʻi. ʻAʻole au i komo i loko o kēia mau ʻike me ka lawe ʻana iā Liptonorm. Mai koʻu ʻeha ʻana mai ka maʻi ʻana o ka pēpē o ka gastrointestinal mai ka wā kamaliʻi me ka liʻiliʻi iki o kaʻu meaʻai, ua huli koke wau i kahi gastroenterologist. Mahalo i ke kauka, ʻike wau i ka mea i hōʻeha i ka ʻōpū ma loko o ka ʻōpū, akā mālama wau no ka nīnau. No ke aha i hōʻike ʻole ai koʻu mea hānaiʻai i nā hopena hiki? "

ʻO Catherine, Novosibirsk: “Ma koʻu mau kaumaha ukana me aʻu mai koʻu wā ʻōpio, akā ma ka makahiki 30 wale nō ua hoʻoholo wau e mālama iaʻu iho a ʻike i ke kumu o koʻu pilikia. Ua hōʻike ʻia nā haʻawina noiʻi he koloka nui ke kumu a ua hāʻawi ʻia e ka mea nāna i hoʻouluulu ka Liptonorm iaʻu.I ka lā mua, ua piʻi koʻu koko koko i ka 150. I ke kakahiaka aʻe i ke kakahiaka he maʻamau ka maʻamau, akā ma hope o ka ʻaina awakea ua lele hou i ka 160. Ma hope o ua hoʻoholo wau e heluhelu hou i nā ʻōlelo aʻo a ma ka hopena ua maopopo wau i ka mea e hana nei. ʻO koʻu koko koko kiʻekiʻe he hopena ia o ka lāʻau lapaʻau. Ua emi ka paipai o ke kao ʻana he 5 mau lā ma hope o ka hoʻomaka ʻana o ka ʻoihana.

Ma ka hōʻuluʻulu ʻana i nā loiloi a pau e pili ana i ka hoʻohana ʻana i nā papa liptonorm, pono e hoʻoholo ʻia e pono ke kūkā i kahi kauka ma mua o ka hoʻohana ʻana iā lākou. ʻO ka mea mua, ʻo kēia no ka meaʻo ka lāʻau lapaʻau i loko o nā pūʻulu o nā statins hiki ke pale aku i ka hoʻonui o ka kolamu. E like me kāu e ʻike ai, ʻo ka koho a hiki paha ke hoʻopau paha i kekahi o nā mea āpau hormonal e hiki ke lawe ʻia e kahi loea.

ʻO ka lua, ua loaʻa i ka lāʻau ākea ka nui o nā contraindications a me nā hopena ʻaoʻao mai ka gastrointestinal tract, Central nervous system, cardiovascular a me nā polokalamu koʻikoʻi ʻē aʻe. Pono ke mea loea e kuhikuhi i kahi dosage, wehewehe i nā hiʻohiʻona āpau o ke noi, a hōʻike hoʻi i ka mea maʻi e pili ana i nā hoʻopiʻi hiki.

ʻLoe a me ke kākele

Ma mua o ke kuhikuhi ʻana i ka Liptonorm a me ka manawa holoʻokoʻa o kāna hoʻohana ʻana, pono ke ahonui e pili i kahi meaʻai e hāʻawi ai i ka emi ʻana o nā lipid koko.

Lawe ʻia ka lāʻau lapaʻau ma ka manawa 1 i ka lā, ʻaʻole me ka ʻai, i ka manawa like.

ʻO ka maʻa mua o kēlā me kēia lā maʻamau ʻo 10 mg. A laila, hoʻololi ʻia ka pākolo i ke kū hoʻokahi, e pili ana i ka maʻi kolamu o ka lipoproteins haʻahaʻa haʻahaʻa. ʻAʻole hoʻi e emi ma waena o nā hoʻololi i waena o ka hopena i lalo o 4 mau hebedoma. ʻO ka helu ʻeha loa i kēlā me kēia lā he 80 mg.

Nā hopena hopena

Hiki i nā hopena hopena o ka lāʻau (pinepine - ʻoi aku ma mua o 2%, loaʻa - ʻaʻole hoʻi ma mua o 2%):

ʻO ka ʻōnaehana o ka poepoe: pinepine - dizziness, insomnia, jarang - malaise, asthenic syndrome, ka ʻeha, ke poʻo, ka poʻomanaʻo, ka hana ʻana i ka naʻau, peropheral neuropathy, ataxia, paresthesia, paralysis o hope, hyperesthesia, hyperkinesia, amnesia, ʻeha, hoʻoluhi ka ʻike.
Pūnaehana Cardiovascular: pinepine ka ʻehaʻeha, pinepine ka postural hypotension, arrhythmia, vasodilation, piʻi ka nui o ka puʻuwai, angina pectoris, hoʻonui i ke koko, phlebitis,
Nā hui ʻōpala: dry conjunctiva, glaucoma, hemorrhage maka, amblyopia, kahi pīhoihoi o ka noho ʻana, parosmia, ke kani nei i nā pepeiao, nā kuli, ka wailua o ka ʻono, ka nalowale o ka hoʻāʻo.
Pūnaehana respiratory: pinepine - rhinitis, bronchitis, jarang - nosebleeds, pneumonia, bronchial asthma, dyspnea,
Pūnaehana digestive: pinepine - cheilitis, kaomi ke kino, ka erosive a me ka ulcerative lesi o ka waha mukosa, stomatitis, glossitis, waha maloʻo, tenesmus, constipation a maʻi paha, ʻehaʻeha, flatulence, nausea, gastralgia, belching, ʻeha o ka ʻōpū, hoʻopuka, dysphagia , esophagitis, anorexia a i ʻole ka nui o ka makemake, ulod duodenal, colic hepatic, gastroenteritis, hepatitis, hana hana kīnā ʻole, jaundice cholestatic, pancreatitis, melena, hoʻolaʻa kulī,
Pūnaehana genitourinary: pinepine - peremaʻi peripheral, maʻi urogenital, jarang - hematuria, nephritis, nephrourolithiasis, dysuria (komo i ka urinary incontinence a urinary retention, nocturia, pollakiuria, mandatory urination), metrorrhagia, vaginal sipula, epididymitis, ejaculation, emi libido, impotence,
Pūnaehana musculoskeletal: pinepine - ka ʻōpū, līpeke - tendosynovitis, bursitis, myositis, myalgia, arthralgia, torticollis, nā wāwae kīwaha, kihi hui pū, nā naʻau hypertonicity, myopathy, rhabdomyolysis,
Hematopoietic ʻōnaehana: lymphadenopathy, anemia, thrombocytopenia,
ʻO ka hopena dermatological a me nā maʻi pākuʻi: jarang - hoʻonui nui loa, seborrhea, xeroderma, eczema, petechiae, ecchymosis, alopecia, gāwili, ʻāwili keʻokeʻo, kontak dermatitis, luhi - edema helehelena, angioedema, urticaria, photosensitivity, multiforme non-toxic exudative erythema ʻO ka maʻi Stevens-Johnson, kahi anaphylaxis,
Nā hōʻailona kuhikuhi: jarang - albuminuria, hypoglycemia, hyperglycemia, hoʻonui i ka hana o ka phosphatase alkali, serum creatinine phosphokinase a hepatic transaminases,
ʻO nā mea'ē aʻe: loaʻa pinepine - mastodynia, gynecomastia, loaʻa ka momona, exacerbation o ka gout.

Nā ʻōlelo kikoʻī

I ka holo ʻana o ka manawa holoʻokoʻa, mālama pono ka nānā ʻana i nā lāʻau lapaʻau a me nā ʻōnaehana o nā hana kino. Inā ʻike ʻia nā loli pathological nui, e hoʻemi ʻia ka nui o ka liptonorm a i hoʻōki ʻole ʻia kona komo ʻana.

Ma mua o ke kau ʻana i ka lāʻau lapaʻau, a laila 6 a me 12 mau pule ma hope o ka hoʻomaka ʻana o ka hoʻōla, ma hope o ka piʻi ʻana o kēlā me kēia mika, ʻo ia hoʻi ka manawa maʻamau i ka wā o ka mālama ʻana (no ka mea, ʻo kēlā me kēia 6 mau mahina), pono ka nānā pono o ka ʻōpala. ʻO ka hoʻololi ʻana i ka hana hoʻoulu e ʻike ʻia i nā malama 3 mua o ka lawe ʻana i ka Liptonorm. I ka hihia o ka hana o ka transaminases hepatic, pono nā mea maʻi e lalo o ka mālama kia ʻana a hiki i ka hoʻihoʻi ʻana o nā hōʻailona. Inā ʻoi aku ka waiwai o ka alanine aminotransferase (ALT) a i ʻole aspartate aminotransferase (AST) iʻoi aku ma mua o 3 mau manawa iʻoi aku ma mua o ka waiwai like o ka congenital adrenal hyperplasia, ua makemake ʻia e hōʻemi i ka hopena a paʻa paha i ka lāʻau.

Pono e hoʻohālikelike i ka pōmaikaʻi i kali ʻia a me ka pae o ka hōʻemi inā pono ke hoʻokō i ka Liptonorm i ka mea maʻi e loaʻa ana i ka cyclosporine, erythromycin, clarithromycin, immunosuppressants, fibroic acid derivatives, nicotinic acid (ma nā inika e loaʻa ai ka hopena lipid-lowing), nā ʻeneka antifungal he mea derivatives azole. Inā loaʻa nā hōʻailona o ka hōʻeha o ka ʻōpū, nāwaliwali, a i ʻole nā lethargy, ʻoi loa i nā malama o nā mahina mua o ka mālama ʻana a i ʻole ka piʻi ʻana o ka hopena o kekahi o nā lāʻau lapaʻau, pono e kiaʻi ʻia nā ʻano o ka mea maʻi.

Inā aia nā mea e pono ai ka hoʻomohala ʻana o ka hana ʻole o ka pilikia a me ka hopena o ka rhabdomyolysis (no ka laʻana, he hypotension arterial, hōʻeha o ka metabola a me nā hopena endocrine, ʻeha hopohopo nui, ka ʻeha, ka hoʻōla nui, ʻohi ʻana ka electrolyte). ka hoʻomohala ʻana o ka myopathy, Liptonorm e hana pōkole a hoʻopau ʻia paha.

Hoʻomaʻamaʻa ʻia ka mea maʻi e pili ana i ka pono e kūkākūkā koke i ke kauka inā loaʻa iā ʻoe nā nāwaliwali a i ʻole ka hoʻowalewale ʻole ʻana o ka ʻehaʻīpili, a ʻoi loa inā ke hele pū lākou me ka malaise a / a i ʻole ke kuni paha.

ʻAʻohe mea i hōʻike i ka hopena maikaʻi o Liptonorm i ka hiki ke lawe i nā kaʻa a hoʻokō i nā hana e pono ai ke nānā aku.

Hoʻohui nūhou

ʻO ka immunosuppressants, nā antifungal māpana i puka mai i azole, fibrates, cyclosporine, erythromycin, clarithromycin, nicotinamide hoʻonui i ka hoʻoliʻi o ka atorvastatin i ke koko koko a me ka hopena o ka hoʻomohala ʻana i ka myopathy.

Hoʻonui hou ʻia ka pae o ka waiwai ikaika o Liptonorm e nā mea paʻa CYP3A4.

Hoʻopau nā antacids i ka hoʻoneʻeʻana o ka atorvastatin e 35%, akā ʻaʻole ia e hoʻopilikia i ke kolamu o ka cholesterol o nā lipoproteins low density.

Ke lawe nei i Liptonorm i kēlā me kēia lā o 80 mg i ka manawa like me ka digoxin, ʻo ke kahe o nā mea hou i loko o ke koko e hoʻonui ma kahi o 20%.

ʻO Liptonorm, lawe ʻia i loko o kēlā me kēia lā he 80 mg o ka lā, e hoʻonui i ka ʻike o nā mea hoʻohālikelike waha e loaʻa ana i ka ethinyl estradiol a i ʻole norethidrone ma 20%.

ʻO ka hopena hypolipidemic o ka hoʻopili ʻana i ka atorvastatin me colestipol ka mea iʻoi aku ka maikaʻi ma nā hopena i loaʻa i kēlā me kēia lāʻau.

Ma ka hihia o ka hoʻohana 'ana i ka warfarin i nā lā mua o ka mālama ʻana, ua emi ka manawa prothrombin, akā ma hope o 15 mau lā o kēia hōʻailona, e like me ke ʻano he kānāwai. No kēia kumu, ʻo nā mea maʻi e loaʻa ana i kahi hui like ʻole e pono e mālama i ka manawa prothrombin i nā manawa pinepine ma mua o ka mea maʻamau.

I ka wā o ka mālama ʻana, ʻaʻole ia e koi ʻia e hoʻopau i ka wai ʻōpana, ʻoiai e hiki ke kōkua i ka hoʻonui ʻana i ke kāʻalo o ka atorvastatin i ka plasma koko.