ʻO POLYCYSTOSIS ʻOʻO OVARIES (PCOS) a i ʻia hoʻi ka manaʻo

ʻO ka manaʻo o ka kūleʻa o ka insulin e hoʻopiʻi i ka emi ʻana o ka hoʻowalewale o nā pūpū i ka hana o ka insulin hormone. Hoʻomaopopo pinepine ʻia kēia maʻi ma nā maʻi me ka maʻi mellitus, akā i kekahi mau manawa, ua hōʻike pū ʻia ka pale ʻana i ka insulin i nā kānaka olakino maikaʻi.

Ke hōʻike nei kahi maʻi e like me ka polycystic ovary syndrome (PCOS) i ka hapanui o nā wāhine i loaʻa i nā maʻi endocrine. Kuhi ʻia ia e ka loli ma ka hana ovarian (hoʻonui ʻia a i ʻole ʻolima ovulation, lohi i ke kekela haehina). Ma 70% o nā maʻi, e hōʻike ana ʻo PCa i ka hele ʻana o ka maʻi mellitus type 2.

ʻO ka pale a me ka pale ʻana i ka insulin e pili pono ana i nā kumumanaʻo a i kēia manawa, ʻike nui nā poʻe ʻepekema i ka manawa e noi ana i ko lākou pilina. ʻO ka maʻi ponoʻī, ʻo ka mālama ʻana no ka maʻi polycystic, ka hopena a me ka hopena o ka hiki ʻana i ka hapai kūlohelohe, ka pilina ma waena o ka maʻi polycystic me ka insulin, a me ka lāʻau eʻai ai no kēia maʻi e wehewehe pono ʻia.

Polycystic

Ua ʻike ʻia kēia maʻi ma ka hoʻomaka ʻana o ke kenekulia hope e ʻelua mau ʻepekema ʻAmelika - ʻo Stein lāua ʻo Leventhal, no laila ke kapa ʻia nei nā maʻi polycystic i kapa ʻia ʻo Stein-Leventhal syndrome. ʻAʻole aʻo ʻia nā etiology o kēia maʻi. ʻO kekahi o nā hōʻailona nui ka hoʻonui ʻia o ka huna ʻana o nā kāne kāne i loko o ke kino o ka wahine (hyperandrogenism). ʻO kēia ma muli o ka hana adrenal aiʻole ovarian.

I ka hihia o PCOS, ua hōʻike ka ovary i kahi hiʻohiʻona morphological - polycystic, ʻaʻohe neoplasms. I loko o nā ovaries, the synthes of the form of the corpus luteum is impaired, progesterone production are block, and the ovulation and menstruation disorder.

ʻO nā hōʻailona mua e hōʻike ana iā Stein-Leventhal syndrome:

• ʻO ka hala ʻole a i ʻole hiki i ka lohi ʻana o nā kāne.
• ʻO ka lauoho lauoho i nā wahi i makemakeʻole ʻia (alo, ke kua, ʻeha, nā ʻōpū ʻihi).
• Huehue, huila ʻaila, ʻuluʻula,
• Loaʻa nā lilo kālā i 10 kg i kahi manawa pōkole loa,
• ʻO ka lauoho lauoho
• ʻO ka huki ʻana i nā hōʻeha ma ka ʻōpū o ka ʻōpū i ka wā menstruation (ʻeha ʻole maʻamau ka maʻi ʻeha o ka maʻi poʻo).

Hoʻololi ʻia ka manawa ovulation o ka wahine me ka loli e ka loli o ka pae o ka hormone e hua ai ka pituitary a me nā ovaries. I ka wā menstruation, hana ʻia ka ovulation ma kahi o nā hebedoma ʻelua ma mua o ka hoʻomaka ʻana. Hoʻokomo ka ovaries i ka hormone estrogen, me ka progesterone, kahi e hoʻomākaukau ai i ka ʻōpū no ka hoʻopaʻa ʻana o kahi hua i hoʻopaʻa ʻia. I kahi palena iki, hana lākou i ka testosterone male kāne. Inā ʻaʻole ulu ka hāpai, a laila hoʻemi ʻia nā pae o ka hormone.

Me ka polycystosis, ua nīpī ka ovaries i kahi nui o ka testosterone. Hiki i kēia mau mea ke alakaʻi i ka maʻi ʻole a me nā hōʻailona ma luna nei. Pono e ʻike ka ʻike ʻana o nā kāne wahine i loko o ke kino ma muli o ka hiki ʻana o nā kāne kāne, e hoʻololi ana iā lākou. Ka mea i ʻole o ka hele ʻana o nā kāne kāne, ʻaʻole hiki ke hana ʻia ka wahine ma ka kino o ka wahine.

Pono e maopopo i kēia, ʻoiai ʻo ka hemahema o kēia loulou e hoʻoiho ai i ka ovary polycystic.

HANOHE ANA PCOS MA AINA

I kēia mau makahiki he 20 i hala aku nei, ua hoʻokumu ʻia ʻo ka hyperinsulinemia ke kumu nui o ka polycystic ovary syndrome (PCOS) i kahi hapa nui o nā wahine. Aia kekahi mau maʻi i kahi "PC metabolic," hiki ke manaʻo ʻia he kūlana prediabetic. ʻO ka manawa pinepine, ʻo kēia mau kaikamahine i loaʻa ka momona, nā kāne hiwahiwa, a ʻo nā ʻohana hoʻi me ka maʻi maʻi.

ʻO ka hapa nui o nā wahine me ka maʻi polycystic ovary syndrome (PCOS) he kūleʻa a me ka momona o insulin. ʻO ka kaumaha nui iā ia iho ke kumu o ka haunaele o ka metabolic. Akā ʻike ʻia ka pale ʻana i ka wahine i loko o nā wahine me PCOS ʻaʻole koʻikoʻi. ʻO kēia ka hapanui ma muli o nā pae o LH a me ka testosterone free serum.

ʻO ka mea nui i hoʻopili ʻia na wahine me ka polycystic ovary ʻo kekahi mau ʻano o nā pūpuna i ke kino - ʻoi loa ka mau manawa a me nā ʻāʻī - he mau kūlohelohe paha o insulin, aʻo nā mea'ē aʻe a me nā ʻālana ʻaʻole paha. A ʻo kahi hopena, nā kelepa pituitary, ovaries a me nā poli adrenal i ka wahine me ke kū ʻana o ka insulin e pane wale aku i nā kiʻekiʻe insulin (a ʻaʻole i pane pono i nā mea maʻamau), e hoʻonui ana i ka luteinizing hormone a me androgens. Ua kapa ʻia kēia ʻano me ka "ʻōpiopio koho."

ʻO ke kumu

Ua manaʻoʻiʻo ia kekahi o nā kumu nui o ka pale ʻana i ka insulin he hoʻonui i ka nui o ka momona. Hōʻike nā haʻawina helu he nui ke kiʻekiʻe o nā momona momona i loko o ke koko e alakaʻi i ka mea pili i nā pūna, me ke ʻano o nā pūpuna o nā ʻiʻo, e kū ka pane ʻana i nā maʻi maʻamau. Hiki i kēia ma ke ʻano o nā momona a me nā metabolites o nā momona momona e ulu ana i loko o nā pūpū o ka naʻau (intramuscular fat). ʻO ke kumu nui no ka hoʻonui ʻia ʻana o nā momona momona momona e ʻai ana i ka nui o nā kalaka a ma ke kaupaona ʻana. ʻO ka overeating, ke kaupaona ʻana a me ke kau momona e pili pū i ka pale ʻana o ka insulin. ʻO ka momona o Visceral ma luna o ka ʻōpū (a puni nā ʻōpū) he pilikia nui. Hiki iā ia ke hoʻokuʻu i ka nui o nā momona momona i loko o ke koko a hoʻokuʻu aku i nā ʻōnaehana maʻi maʻi e alakaʻi ai i ka kūʻē o ka insulin.

ʻO nā wahine me ka kaupaona maʻamau (a ʻoi paha ka momona) i loaʻa paha ka PCOS a me ka kūleʻa o ka insulin, akā ʻoi loa kēia maʻi maʻamau i waena o nā kānaka momona.

Aia kekahi mau kumu kūpono ʻē aʻe o ka maʻi:

Ua hoʻopili ʻia ka intake fructose kiʻekiʻe (mai ke kō ma mua o ka huaʻai) i ka pale ʻana i ka insulin.

ʻO ka hoʻonui ʻana i ke kaumaha o ka oxidative a me ka hoʻowalewale i ke kino hiki ke alakaʻi i ka kūleʻa o ka insulin.

Hoʻopili ka hoʻoikaika kino i ka uluʻana o ka insulin, ʻoiai ʻaʻole ka lohi, ma ke ʻano ʻē, e emi ana.

Aia ma laila he maopopo e hiki i ke kipi o ke ʻano o ka maʻi i loko o ka pūpū ke hoʻomānoʻi i ka maʻi ʻaʻa, kahi e hoʻonāukiuki i ka hoʻomanawanui ʻana o ka insulin a me nā pilikia metabolic ʻē aʻe.

Eia kekahi, aia nā mea genetic a me nā mea koʻikoʻi. Ua manaʻo ʻia aia paha he 50% o ka poʻe i loaʻa i ke ʻano o kēia ʻino. Aia paha kekahi wahine i kēia pūʻulu inā he moʻolelo ʻohana kona i ka maʻi maʻamau, ka maʻi cardiovascular, hypertension, a i ʻole PCOS. Ma kekahi mea, he 50% kaʻe o ka inikua ulu ʻia ma muli o kahi meaʻai maikaʻi ʻole, ʻūlū a me ka nele o ka hoʻomaʻamaʻa.

Nā huapau

Inā kānalua ka polycystic ovary, kuhikuhi mau nā kauka i nā hoʻokolohua kū i ka insulin no nā wahine.

ʻO ka wā hoʻomaha o ka insulin kiʻekiʻe he hōʻailona o ke kū'ē.

Hoʻolālā ka hōʻike hōʻike HOMA-IR i ka hōʻailona kūʻai o ka insulin, no kēia hāʻawi i hāʻawi ʻia i kēia glucose a me ka ʻaina wikiwiki. ʻOi aku ka kiʻekiʻe, ʻoi aku ka ʻino.

Ka hoʻāʻo ʻana ka mea hoʻohaʻahaʻa glucose a me ka mau hola ʻelua ma hope o ka lawe ʻana i kekahi nui o ke kō.

Hoʻokomo ʻo Glycated hemoglobin (A1C) i ke kiʻekiʻe o ka glycemia i nā mahina ʻekolu i hala aʻe nei. Pono ka pae kūpono loa ma lalo o 5.7%.

Inā nui ka momona o ka wahine, ʻeha a me ka nui o ka momona ma kahi o kona pūhaka, a laila kiʻekiʻe loa ka manawa kūpono o ka pale ʻana i ka insulin. Pono pono e nānā ke kauka i kēia.

1. ʻEleʻele (Negroid) Acanthosis

ʻO kēia ka inoa o ke ʻano o ka ʻili e nānā ʻia ai nā wahi uliuli i kekahi mau wahi, me nā leʻaleʻa (nā lima lima, nā ʻāʻī, nā wahi ma lalo o ka umauma). ʻO kona heleʻana e hōʻike pū i ka kūʻē o ka insulin.

ʻO ka lua HDL haʻahaʻa "" maikaʻi "a me nā kiʻekiʻe triglycerides ʻelua mau hōʻailona nui e pili nui ana i ka pale ʻana i ka insulin.

ʻO ka nui o ka insulin a me ke kō ka hōʻailona me ka hōʻailona nui o ka pale ʻana i ka insulin i nā ovaries polycystic. ʻO nā hōʻailona ʻē aʻe he nui o ka momona o ka ʻōpū, hoʻokiʻekiʻe ʻia, a me HDL haʻahaʻa.

Pehea e ʻike ai e pili ana i ka kūleʻa ʻia o ka insulin

Loaʻa i kahi wahine kēia pilikia inā he ʻekolu a ʻoi aku paha kēia mau hōʻailona:

• nā kuʻi koko nui (maʻa aʻe o ka 140/90),
• ʻoi aku ka paona maoli ma mua o 7 kg a i ʻole,
• hoʻokiʻekiʻe ʻia nā triglycerides,
• kiʻekiʻe loa ka kolamu ma mua o ka maʻamau
• "Maikaʻi" cholesterol "HDL) ma mua o ka 1/4 o ka nui,
• hoʻokiʻekiʻe ka uric acid a me ka pae,
• ua hoʻonui ʻia ka hemoglobin glycated,
• hoʻokiʻekiʻe ʻia
• haʻahaʻa haʻahaʻa o ka magnesium i loko o ka plasma.

Nā hopena o ka hoʻonui ʻana i ka insulin:

• polycystic ovary syndrome,
• huehue
• hoʻoluhi
• hoʻōla
• maʻi maʻi
• nā kauā no ka ʻaila a me nā ʻalā,
• apple-type obesity a paʻakikī paʻakikī e waiho i ka paona
• koko koko kiʻekiʻe
• maʻi maʻi maʻi
• māhāla
• nā maʻi maʻi
• pilikia ʻē aʻe
• hoʻemi ʻia ka manaʻolana ola.

NA INISULIN KAANUI, PCOS A METABOLIKA MAILANUI

ʻO ka pale kūlohelohe he hōʻailona ia o nā kūlana maʻamau maʻamau - metabolic syndrome a me nā maʻi diabetes type 2. ʻO ka Metabolic syndrome kahi hui o nā hopena pili i pili i ka maʻi type 2, ka maʻi naʻau, a me nā pilikia ʻē aʻe. Pākuʻi ʻia nā ʻōmaʻa ma nā kiʻekiʻe triglycerides, haʻahaʻa HDL, ke koko kiʻekiʻe, ke ana o ke kikowaena (momona a puni ka hope, a me ke kō koko kiʻekiʻe. ʻO ke kūlohelohe insulin kekahi mea nui i ka hoʻomohala ʻana o ka maʻi type 2.

Ma ke kaohi nei i ka holomua o ka kūʻē o ka insulin, hiki i ka hapa nui o nā hihia o ka metabolic syndrome a me nā maʻi laikini 2 ʻano.

ʻO ka paleʻana i ka insulin he kuhi i ka metabolic syndrome, ka maʻi o ka naʻau, a me ka maʻi diabetes 2 ʻano, aia kēia ma waena o nā pilikia olakino maʻamau. Nui nā maʻi ʻē aʻe e pili pū ana i ka pale ʻana o ka insulin. Hoʻopili kēia i ka maʻi pāpaona momona haukapila, polycystic ovary syndrome (PCOS), maʻi a Alzheimer a me ka maʻi kanesa.

KA LAHUI E PILI ANA I KE KAI ANO I KĀNA I KA PĀHAI O KOLOHE O OVARIES

ʻOiai ʻo ka paleʻana o ka insulin he mea hōʻeha hewa loa e alakaʻi i nā hopena koʻikoʻi, hiki ke hoʻohui ʻia. ʻO ka lāʻau lapaʻau me ka metformin ka mālama koʻikoʻi i kuhikuhi ʻia e nā kauka. Eia nō naʻe, ʻo nā wahine me nā ʻano like ʻole o ka insulin e kū i ka PCOS e hiki ke hoʻōla ʻia ma ka hoʻololi ʻana i ko lākou ola.

ʻO kēia ke ala maʻalahi loa e hoʻomaikaʻi ai i ka naʻau o ka insulin. E ʻike koke ʻia ka hopena. E koho i ka hana kino āu e makemake ai a maikaʻi loa: holo, hele wāwae, ʻauʻau, ka uila. He maikaʻi e hoʻohui i nā haʻuki me yoga.

He mea nui e nalowale i ka momona visceral momona, aia i loko o ka ʻōpū a me ka puʻuwai.

Hiki i nā pīpī ke hana i ka pale ʻana i ka insulin a hoʻonāukiuki i ke kūlana ma nā wāhine me ka polycystic ovary.

1. Hoʻokiʻoki i ke kō

E hoʻāʻo e hōʻemi i ka nui o kāu kōʻai, mai nā wai momona e like me ka soda.

1. ʻAi Kaila

Pono kaʻai ʻana no nā polycystic ovary e pili ana i nā meaʻai ʻole i loaʻa. Loaʻa pū kekahi i nā nati a me ka iʻa lauʻaʻai i kāu papaʻai.

ʻO ka ʻai momona o ka omega-3 hiki ke hoʻohaʻahaʻa i nā triglycerides koko, ke piʻi pinepine ʻia nei me nā maʻi ovary polycystic a me ke kū'ē o ka insulin.

Lawe i nā mea hoʻohui e hoʻonui ai i ka naʻau o ka insulin a me ke kōpaʻa koko. Hoʻopili kēia me ka laʻi, magnesium, berberine, inositol, vitamina D a me nā mea pena e like me ka cinnamon.

Aia ma laila he hōʻike no ka nele, ʻo ka hiamoe pōkole kekahi i kumu i kū i ka insulin.

He mea nui ia no nā kaikamahine me ka polycystic ovary e aʻo pehea e hoʻokele ai i ke kaumaha, ka luhi a me ke kaumaha. Hiki i nā yoga a me nā lako lako me nā huaora B me ka magnesium hiki ke kōkua ʻia ma ʻaneʻi.

Hoʻopili nā pae kiʻekiʻe o ka hao me ka pale ʻana i ka insulin. Ma kēia kūlana, hāʻawi ka hāʻawi koko koko, ke hoʻololi ʻana mai ka ʻiʻo i ka ʻai ʻana i nā lau ʻai, a me ka hoʻopili ʻana o nā huahana ʻoi aku ka nui o ka wai i ka meaʻai e hiki ke kōkua i nā wahine postmenopausal.

ʻO ka paleʻana i ka insulin i ka wahine me ka polycystic ovary hiki ke hoʻohaʻahaʻa loa a hiki ke hōʻemi maikaʻi ʻia me nā loli ola maʻalahi, kahi e loaʻa ai ka meaʻai maikaʻi, hoʻohui, ʻokoʻa kino kino, hoʻemi kaumaha, hiamoe maikaʻi, a me ka hoʻohaʻahaʻa ʻana.

Abstract o kahi ʻepekema ʻōlelo lāʻau i ka lāʻau a me ka olakino lehulehu, ka mea kākau i kahi pepa ʻepekema ʻo Matsneva I.A., Bakhtiyarov K.R., Bogacheva N.A., Golubenko E.O., Pereverzina N.O.

ʻO Polycystic ovary syndrome (PCOS) kekahi o nā hana maʻamau o ka endocrinopathies. ʻOiai ka hoʻonāukiuki nui o PCOS a me ka mōʻaukala lōʻihi o ka noiʻi, ka etiology, pathogenesis, ka maʻi a me ka mālama ʻana i ka ʻatikala ke hoʻomau nei loa. I nā makahiki i hala iho nei, ua loaʻa ka manaʻo o nā poʻe ʻepekema i ka nīnau o ke kōkua o ka hyperinsulinemia i ka hoʻolālā ʻana o PCOS. Ua ʻike ʻia ma 50-70% o nā hihia a hui pū ʻia ʻo PCOS me ka momona, hyperinsulinemia a me nā loli o ka spidididula momona, ke hoʻonui nei i ka pilikia o ka hoʻomohala ʻana i nā maʻi cardiovascular, type 2 diabetes a alakaʻi i kahi ka hoʻemi ʻana i ka manaʻolana o ke ola maʻamau. ʻO ka nui o nā mea noiʻi e kuhikuhi ana i ka hoʻoholo genetic o nā hana kūlohelohe i PCOS, ka hōʻikeʻike i kahi e hoʻonui nuiʻia i mua o ka nui o ke kaumaha o ke kino. Ka hana i kēia manawa i ka hoʻopaʻa ʻana o ka pathogenesis o PCOS i hōʻike ʻia e ka noiʻi hohonu o ka hōʻea o ka metabolic: ka kū ʻana o ka insulin, ka hyperinsulinemia, ka momona o ka maʻi hyperglycemia, dyslipidemia, ka hana systemism, ka hoʻāʻo ʻana i kā lākou hopena kūlohelohe i ke kaʻina pili i nā ovaries, a me nā maʻi pili i like me ke ʻano o ka mellitus non-insulin-dependence a me ka cardiovascular maʻi. E wehewehe kēia i ka ʻimi no ka ʻike ʻana i kahi maʻi hou e hoʻoholo ai i kahi o nā māka e hiki ke hoʻohana i ka hana maʻamau i kēlā me kēia lā e like me ka poʻe wanana o ka metabolic a me ka puʻuwai maʻi maʻi ma nā maʻi me PCOS.

KA INAHOLO KA HUI A ME KA LAHUI E KĀNA I KA PONO O KA POLISI ALOHA

ʻO Polycystic ovarian syndrome (PCOS) kekahi o nā ʻano pinepine o ka endocrinopathies. ʻOiai ka lōʻihi o ka PCOS a me ka lōʻihi o ka manawa o ke aʻo ʻana, ʻo nā pilikia o ka etiology, pathogenesis, ka maʻi a me ka mālama ʻana i ka maʻi maʻi e hoʻomau wale nei. I nā makahiki i hala iho nei, ua loaʻa ka manaʻo o nā poʻe ʻepekema i ka nīnau o ke kōkua o ka hyperinsulinemia i ka hoʻolālā ʻana o PCOS. Ua ʻike ʻia aia ma ka 50-70% o nā hihia a hui pū ʻia ʻo PCOS me ka momona, hyperinsulinemia a me nā loli i ka kū i ka lehelehe> insulin resistance, hyperinsulinemia, obesity, hyperglycemia, dyslip> systemic inflammation, ka noiʻi ʻana i kā lākou hopena kūlohelohe i ke kaʻina pili ovaries, a me nā maʻi e pili ana i ka maʻi e like me ka insulin-kūloko kūloko mellitus a me nā maʻi cardiovascular. Hiki i kēia ke wehewehe i ka ʻimi no ka ʻike ʻana i kahi diagnostic hou e hoʻoholo ai i kahi o nā māka e hiki ke hoʻohana i loko o ka hana maʻamau i kēlā me kēia lā e like me nā poʻe wānana o nā kuʻuna metabolic a me cardiovascular i nā maʻi me PCOS.

ʻO ka kikokikona o ka hana ʻepekema ma ke kumumanaʻo "Ka hoʻonāukiuki a me ka pale ʻana o ka insulin i ka polycystic ovary syndrome"

KA INAHANAʻO KA ʻĀKAHI A ME KA HOOPONOPONO LOA

Matsneva I.A., Bakhtiyarov K.R., Bogacheva N.A., Golubenko E.O., Pereverzina N.O.

ʻO FGAOU VO ʻOi Ke Kulanui Kau Lākana o Moscow e kū nei ma hope o I.M. Sechenov (Ke Kulanui Sechenov), Moscow, Russian Federation

Hoʻohālikelike. ʻO Polycystic Ovary Syndrome (PCOS) kekahi o nā hana maʻamau o ka endocrinopathies. ʻOiai ka hoʻonāukiuki nui o PCOS a me ka mōʻaukala lōʻihi o ka noiʻi, ka etiology, pathogenesis, ka maʻi a me ka mālama ʻana i ka maʻi maʻi ke hoʻomau i ka debatable. I nā makahiki i hala iho nei, ua loaʻa ka manaʻo o nā poʻe ʻepekema i ka nīnau o ke kōkua o ka hyperinsulinemia i ka hoʻolālā ʻana o PCOS. Ua ʻike ʻia ma 50-70% o nā hihia a hui pū ʻia ʻo PCOS me ka momona, hyperinsulinemia a me nā loli o ka spidididula momona, ke hoʻonui nei i ka pilikia o ka hoʻomohala ʻana i nā maʻi cardiovascular, type 2 diabetes a alakaʻi i kahi ka hoʻemi ʻana i ka manaʻolana o ke ola maʻamau. ʻO ka nui o nā mea noiʻi e kuhikuhi ana i ka hoʻoholo genetic o nā maʻi metabolic i PCOS, ka hōʻikeʻike i kahi e hoʻonui nui ai i ke alo o ka nui o ke kaumaha o ke kino. Ka hana i kēia manawa i ka hoʻopaʻa ʻana o ka pathogenesis o PCOS i hōʻike ʻia e ka noiʻi hohonu o ka hōʻea o ka metabolic: ka kū ʻana o ka insulin, ka hyperinsulinemia, ka momona o ka maʻi hyperglycemia, dyslipidemia, ka hana systemism, ka hoʻāʻo ʻana i kā lākou hopena kūlohelohe i ke kaʻina pili i nā ovaries, a me nā maʻi pili i like me ke ʻano o ka mellitus non-insulin-dependence a me ka cardiovascular maʻi.

E wehewehe kēia i ka ʻimi no ka ʻike ʻana i kahi maʻi hou e hoʻoholo ai i kahi o nā māka e hiki ke hoʻohana i ka hana maʻamau i kēlā me kēia lā e like me ka poʻe wanana o ka metabolic a me ka puʻuwai maʻi maʻi ma nā maʻi me PCOS.

ʻO nā huaʻōlelo nui: ke kū'ē i ka insulin, nā ʻōkuhi o ka systemic, polycystic ovary syndrome, hyperinsulinemia, hyperandrogenism.

ʻO nā pilikia o ka huliʻana i ka polycystic ovary syndrome e pili pono ana i kēia manawa, ʻoiai ʻoiai ua wehewehe mua ʻia ka PCOS e Stein lāua ʻo Leventhal i ka makahiki 1935. ʻAʻole kū i nā paona pono kūpono no ka maʻi a hiki i ka 2003, i ka manawa i ʻōlelo ʻia ai nā koina Rotterdam. Ua komo kēia mau ʻōlelo:

1. Kūʻai uila / anovulation.

2. Kalima / laboratemone ka hyperandrogenism.

3. Nā pākaukau Polycystic.

Akā ʻo kēia manawa, ʻo ka hopena o ka PCOS e hōʻeha i kekahi mau pilikia, kahi hoʻokūkū pololei i hoʻokumu ʻia ma hope o ka lōʻihi a, pinepine, hoʻonāukiuki a me ka mālama ʻana. I kēia lā hiki ke wehewehe i ka makemake o nā mea noiʻi ma kēia pilikia.

Hoʻopilikia ka polycystic ovary syndrome i 2% -20% o nā wahine, a ʻo ia ka endocrinopathy maʻamau maʻamau i nā wahine o nā makahiki hānau. ʻO ka nui o ka pilikia ma ka honua he 3.5%.

I nā makahiki i hala iho nei, ua loaʻa ka manaʻo o nā poʻe ʻepekema i ka nīnau o ke kōkua o ka hyperinsulinemia i ka hoʻolālā ʻana o PCOS. Ua ʻike ʻia ʻo ka hapa nui o nā poʻe maʻi me PCOS he kū i ka insulin, a ma kahi o 50% o nā mea maʻi e hālāwai me ke kūleʻa no ka metabolic syndrome 2,3. Hoʻopili pinepine ʻia ʻo PCOS me ka B-cell dysfunction, e hoʻonui ana i ka pilikia o ka maʻi diabetes type 2. I nā wahine me PCOS, ʻoi aku ka nui o kēia pilikia ma ka hoʻohālikelike i nā wahine olakino o ka paona like a me ka nui makahiki. Hoʻokomo ʻia ka Insulin i ka hana p450c17 i nā ovaries a me nā koikoi adrenal, ke alakaʻi nei i ka hoʻonui o ka hana androgen.

Loaʻa ka pathogenesis o PCOS me ka hyperandrogenism, ka momona nui, a me ka kū'ē o ka insulin (hyperinsulinemia). Hāʻawi ka kiʻekiʻe o ka testosterone kiʻekiʻe i ka ʻōpū o ka ʻōpū, kahi e hiki ai ke pale i ka insulin. Hoʻokomo ka insulin i ka hyperinsulinemia a laila hoʻoulu i ka hoʻonui ʻia ʻana o ka huna kino o nā ovaries a me nā kūmole adrenal, pale i ka hana o ka wahine wahine hana hoʻopili globulin (SHBG), a ma laila e hoʻonui ai i ka hana testosterone. Ka pale aku ʻana o ka insulin

a me ke koʻikoʻi o ka hopena i ka hopena o ka hyperandrogenism ma PCOS e pili ana i ka hana maʻi nui a me ka hoʻonui ʻia ʻana o ka adipokines, interleukins a me nā chemokines, i hoʻonui ai i ka pilikia

ka hoʻomohala ʻana o ka maʻi diabetes a me nā maʻi cardiovascular.

Nā huaʻalani a me ka ʻike ʻole

Oihana 1. Kūʻai pōʻai ma PCOS.

KAUA MUA KEKAHI DANISHI. Endocrine a me ka metabolic hiʻohiʻona ma ka polycystic ovary syndrome. Dan med j

Ke kūlohelohe ʻia. ʻO ka paleʻana o ka insulin e pili kokoke i ka index mass body (BMI), akā aia pū kekahi i nā mea maʻi me ka kaumaha maʻamau ma PCOS. ʻAʻole maopopo ka mīkini maoli o ka pale ʻana i ka insulin ma PCOS. Ua loaʻa i nā maʻi PCOS ka like a me ka like like me ka insulin receptor i hoʻohālikelike ʻia i nā wahine olakino, a no laila, ua pale ʻia ka kū ʻana o ka insulin e nā hoʻololi ʻana i ka kaila transduction o ka hōʻailona i hoʻolilo ʻia e ka insulin receptor. Eia kekahi, ua hoʻopiʻi ka pōkole me ka ole o oxidative metabolism i loko o nā mea maʻi me PCOS i nā haʻawina me ka hoʻohana ʻana i nā hana calorimetry kūhelu. Ma kēia mau noiʻi, ua hoʻemi ʻia ka insulin-stim-non-oxidative glucose metabolism i ʻoi aku ka ikaika ma mua o ka hoʻāla glucose oxidative, e kākoʻo ana i ka emi o ka hana glycogen synthase ma PCOS. ʻO ka hana nāwaliwali o ka glycogen synthase e hōʻoia ʻia e nā noi ʻana o ka biopsy o ka mālo i nā mea maʻi. Ua hōʻike ʻia kēia mau noiʻi ua loaʻa nā maʻi me ka PCOS i ka insulin i ka hōʻailona ma o Akt a me AS160, a me ka hana o ka maʻi glycogen synthetase i hana ʻia e ka hoʻohālikelike ʻia me ka hui pū. I kekahi mau mea maʻi me PCOS, ua hoʻonui ʻia ka serine phosphoryl.

ʻO ka mea i hoʻopaʻa ʻia i ka insulin b, akā ua loaʻa pū nā wahi ʻē aʻe o ka insulin receptor cascade 6.7.

ʻO ka paleʻana i ka insulin i ka wahine me PCOS ma muli o nā ʻano genetic a i ʻole nā ​​ʻano hana adaptive e like me ka obesity a me ka hyperandrogenism. Ka loiloi hou ʻia kēia mau hana i loko o nā ʻili puʻuwai mākala i loaʻa mai nā mea maʻi me ka pale ʻana o ka insulin ma PCOS a me nā wahine olakino 8.9. Kuhi i ka hana o ka insulin, ka mea e hoʻomau nei i nā nalo i hoʻoneʻe ʻia mai ka mea waena i vivo, manaʻo ʻia o kēia mau hoʻololi ka hopena o nā mutations i nā ʻano āpau e hoʻoponopono i nā ala hoʻolaʻa hōʻailona. Ua ʻike nā ʻepekema ʻepekema me ka uptake glucose a me ka hāhā, glycogen synthesis, a me ka lipid uptake i hoʻohālikelike ʻia ma waena o nā mea maʻi me PCOS a me nā wahine olakino, a he ʻano like me ka hana mitochondrial o 6.7. Hōʻike kēia mau hopena i ka kū ʻana o ka insulin i ka PCOS me ka hopena o ka mīkini adaptive. Hoʻonui ka hoʻonui ʻia ʻana o ka moleka insulin pancreatic i wahi e uku ai no ka kū ʻana o ka insulin. Pēlā nō, ʻo ka hyperinsulinemia ma PCOS kekahi mea hiki ke hoʻomālamalama mau i ka pale ʻana o ka insulin.

Ua hōʻike ʻia nā noiʻi ua loaʻa nā mea ʻokiʻena insulin i nā ovaries maʻamau a me ka polycystic ovaries. I loko o ka synergy me LH, e hoʻoulu ana ka insulin i ka hana o p450c17 i nā ovaries a me nā aila adrenal a alakaʻi i kahi hoʻonui o ka hana o androgens. Ua hōʻoia nā haʻawina ʻo nā cell theca i nā mea maʻi me PCOS ka mea i ʻoi aku ka naʻau o ka hopena e hoʻoulu ai i ka androgen ma mua o nā ovaries maʻamau. No laila, ʻo ka insulin e hiki ke hana me ka gonadotropin, e hāʻawi ana i ka hoʻonui ʻana i ka hoʻāla ʻana o ka androgens mai nā pūnaewele loea. Eia kekahi, hōʻemi nā hyperinsulinemia i ka hana o SHBG i ka puʻuwai. Mahalo i kēia hana, hoʻonui ai i nā pae testosterone paeʻokoʻa. Eia nō hoʻi, ua hoʻolele ʻia nā pae SHBG haʻahaʻa i ka hopena o ke PCOS a hoʻopili ʻia me ka naʻau haʻahaʻa o ka insulin i nā hoʻokolohua hyperinsulinemic euglycemic.

Hiki i ka testosterone ke hoʻonui i ka pale ʻana i ka insulin a i ʻole kūlike hoʻi. Hoʻokomo ʻia ka testosterone ma ka supraphysiological doses i loko o nā wahine i ukali pū ʻia e ka pale ʻana i ka insulin, loiloi ʻia ma ka hoʻohana ʻana i ka hoʻokolokolo euglycemic. Eia kekahi, hiki i nā kiʻekiʻe o ka testosterone keʻike i ke kōmole o ka ʻōpū, hiki iā ia ke hoʻihoʻi pono i ka pale ʻana i ka insulin. Nā PCOS phenotypes me ka hyperandrogenism i ʻoi aku ka ikaika o ka insulin ma mua o nā phenotypes me ka ʻole o ka hyperandrogenism, ka mea i hōʻoia pū i ka waiwai o nā hyperandrogenism i ka pale ʻana i ka insulin ma PCOS.

ʻO ka ʻōhumu a me nā hōʻailona hōʻailona. Wahi a nā haʻawina, ma kahi o 75% o nā mea maʻi me PCOS ka momona, a ke nānā nei ke kikowaena kikowaena i nā mea maʻi me ka maʻa mau a me ke kaumaha. ʻO ka nui o ka hoʻomake ʻana o ka ʻai ʻana, he aneane 40% i loko o nā wahine me ka hansutism, a ʻoiai, me nā wahine me PCOS, ua pāhola nui ka bulimia. ʻAʻole i emi ka hua o ka metabola i nā poʻe maʻi me ka PCOS, a i nā hoʻokolohua ʻole ʻana, ʻaʻohe ʻano ʻē aʻe i hiki ke hoʻemi ka nui ma waena o nā mea maʻi me PCOS a me nā wahine olakino i ka meaʻai like. Eia nō naʻe, ʻo ka huna ʻia o ka ghrelin ma hope o kaʻai ʻana i ka mea i emi ʻia ma PCOS i hoʻohālikelike ʻia me nā wahine olakino, e hōʻike ana i ka maleʻe o ka ʻai ʻoluʻolu. Hoʻonilo nui ʻia ʻo Grelin e nā sela endocrine o ka ʻōpū. Ke hoʻonui nui nei ka pae ʻana o ka Ghrelin i ka wā pōloli a hoʻemi i ka wā ʻaina. Hoʻēmi ka sekene Grecin i ka wā hoʻoili maikaʻi o ka ikehu, e like me ka momona. Hōʻike ʻia ʻo Ghrelin i nā pūleka beta pancreatic a hiki ke pale i ka huna ʻana i ka insulin. ʻO ka ghrelin haʻahaʻa e pili pū ana i ka pale ʻana i ka insulin a me ka maʻi diabetes. ʻO ka pilina kūpono ʻo Ghrelin me

ʻo adiponectin a i hope me ka leptin. Ua hōʻike ʻia nā haʻawina mua i nā haʻahaʻa o ka ghrelin i nā maʻi me PCOS i hoʻohālikelike ʻia me nā wahine olakino.

Ua hōʻike nā noiʻi i kahi emi o ke ola o PCOS i pili me ka hoʻonui ʻana i ke kaupaona kino. ʻO ka viseral obesity e pili ana i ka pale ʻana i ka insulin a me ka morbidity hoʻonui, ʻo ka mea maʻamau i hoʻopili ʻia e kahi kūlana o ka ulu ʻana o ka luhi. Hoʻopuka a me ka hoʻokuʻu i nā kiko o Adipose i nā huina o nā protein bioactive, i hōʻiliʻili ʻia i kapa ʻia ʻo adipokins. Ma waho o ka leptin a me ka adiponectin, ʻaʻole i hana ʻia ka adipokines kūʻokoʻa wale nō e ka adipocytes, ʻike ʻia lākou e ka macrophages momona. Me ka momona nui, hoʻonui ʻia ka nui o nā macrophages momona i loko o ke kiko kikoʻī a me ka kiko adipose visceral, a me ka hoʻopuni ʻana i nā cell mononuclear i ikaika. Hoʻonui ka mea huna o ka adipokines e wānana i ka metabolic syndrome a hoʻonui i ka pilikia o ka hoʻomohala ʻana i ka maʻi diabetes.

ʻO Adiponectin ka pānaʻi huna ākea maʻamau a ʻike ʻia e ka iwi adipose kūʻokoʻa. Hoʻēmi ka huni o Adiponectin me ka momona. Ua pili pū ʻia ka adiponectin kahe liʻiliʻi me ka piʻi nui o ka pale ʻana i ka insulin a me ka hoʻomohala ʻana i ka maʻi type 2. ʻO nā hana e hoʻohālikelike ai ka adiponectin i ka hoʻomaopopo ʻana i ka insulin. Ua hōʻike ʻia nā holoholona a me nā ʻaina vitro e hoʻopili ai ka adiponectin recombinant i ka hoʻāʻo ʻana o ka muscular a me ka hepatic o ka glucose, hoʻoneʻe i ka pae o ka gluconeogenesis i loko o ka ate, a me ka hoʻolauleʻa ʻana i ka hoʻōho o nā waikawa momona i loko o ka mākala huika. No laila, hoʻemi ka nui o adiponectin i ka kiʻekiʻe o ka triglyceride a hoʻonui i ka naʻau. Hiki pū i kahi Adiponectin ka hopena pololei i ka hana ovarian. Loaʻa ka poʻe Adiponectin receptors i nā ovaries a me ka endometrium. ʻO nā selika Theca i nā mea maʻi me PCOS i ka lalo o ka hōʻike o ka receptors adiponectin i hoʻohālikelike ʻia me nā ovaries o nā wahine olakino. I nā haʻawina, pili me ka hoʻoulu ʻana o ka adiponectin me ka hoʻohaʻahaʻa ʻana i ka hana androgen production. Ua hōʻoia kēia mau hopena i ka pilina koʻikoʻi ma waena o ka momona, adiponectin, a me ka hyperandrogenism ma PCOS. I ka hoʻonui ʻana o ka testosterone i ka poʻe maʻi maʻi obese a me PCOS hiki ke hoʻopaʻa ʻia e ka hoʻemi ʻana i ka adiponectin.

ʻO Leptin ka adipokine i wehewehe mua ʻia a he waiwai koʻikoʻi i ka hoʻoponopono ʻana i ka ʻai o ka ʻai a me nā lilo o ka ikehu. Leptin kū i waho

nā adipocytes, ke pale i ka mea e kau ai i ka meaʻai a hoʻonui i ka lilo o ke kālā. Hoʻopilikia ka Leptin i ka hypothalamus a me ka hoʻopalepili pituitary a ʻaʻole hiki ke hoʻopilikia wale i ka hoʻoponopono o ka lawehala hypothalamic wale nō, akā ʻo ka syena pūnao. I nā kiʻi, hoʻomaikaʻi ʻia nā inikini leptin i ka hoʻomohala ʻana a ovarian follicle no ka mea Loaʻa nā mea i loaʻa i ka leptin i nā ovaries, e hōʻike ana he hiki paha i ka leptin ke kumu koʻikoʻi no ka hana gonad. Ua hōʻike pū ʻia nā noiʻi i nā pilina maikaʻi ma waena o leptin a me BMI, ka pale ʻana o ka hope a me nā pae o ka kūʻē o ka insulin.

No nā macrophages e hoʻomoe i ka LDL (nā lipoproteins haʻahaʻa haʻahaʻa), pono lākou e hoʻonui i ka ʻāina, hana i ka oxLDL he ʻano atherogenic o LDL. Ua hoʻonui ʻia nā pae o ka mokulele OxLDL i nā maʻi me PCOS i hoʻohālikelike ʻia me nā wahine olakino. Eia kekahi, hoʻohālikelike nā pae o ka mokulele OxLDL i nā mea maʻi me PCOS me ka maʻamau a me ke kaupaona ʻana, no laila ke kuhi nei ka hui liʻiliʻi ma waena o ke kaumaha o ke kino a me ka oxLDL o 25.26. Ua hōʻike ʻia ʻo CD36 ma ka ʻaoʻao o nā monocytes a me nā makcrophages. Hoʻomaka ʻia ka hoʻokumu ʻana o nā ʻoi aihue e ka hoʻopili ʻia ʻana o ka mea hoʻokipa o ka oxLDL i CD36, ka mea hana i ka hana CD36 i kahi pilikia no ka maʻi cardiovascular. Hiki i ke kōleo kōmoli (sCD36) ke ana i ka plasma a hiki i ke kūleʻa ʻia me ka kūleʻa o ka insulin a me ka glucose. Ua loaʻa ka hui maikaʻi ma waena o sCD36 a me insulin a me BMI. Loaʻa nā maʻi PCOS i nā kiʻekiʻe sCD36 iʻoi aku ma mua o nā wahine olakino o ka paona like.

ʻIke ʻia ʻo HsCRP e hūnā ʻia i ka pane ʻana i nā cytokines, e komo pū ana me IL-6. ʻO ka hsCRP Elevated ka ikaika nui o ka wana e hoʻohālikelike i ka hopena cardiovascular. ʻAʻole hiki i ka HsCRP ke lilo wale i hōʻailona o nā maʻi maʻi, akā hiki ke hoʻonui ʻia i ke kaʻina o ke kuni i ka hoʻōla hou ʻana i nā monocytes a me nā cell endothelial. Ua loaʻa nui nā maʻi PCOS i ka kiʻekiʻe o ka hsCRP i hoʻohālikelike ʻia i nā wahine olakino. Ma nā hōʻike-analike i kēia manawa, aia ka pae o CRP ma ka awelika 96% i hoʻonui ma PCOS e kūʻē i ka pūʻulu mana a me ka hoʻomau e hoʻonui ma hope o ka hoʻoponopono ʻana no BMI. Loaʻa ʻia ka pololei ʻana o hsCRP me nā hōʻailona o ka momona o ka DEXA

misa, ʻoiai ʻaʻole i loaʻa ka hopena nui i ka wā e ʻike ai i ka testosterone a ana ʻole i ka metabolism glucose.

Hoʻokaʻa ʻia ka Prolactin ʻaʻole e ka kelima kanalula wale nō, akā, ma nā macrophages o ke kiko adipose e pane ai i ka mumū a me ka hoʻoliʻi kiʻekiʻe. I nā hana noiʻi, ua hoʻopili ʻia ka prolactin kiʻekiʻe me ka nui o ka helu ʻana i ka nui o ke koko a me nā maʻi autoimmune. ʻO ka hypothesis e hiki ke hana ka prolactin e like me ka adipokine i kākoʻo ʻia e nā noiʻi ʻana i nā mea maʻi me ka prolactinomas. ʻO nā mea maʻi me ka prolactinoma he kū i ka insulin, hoʻonui ʻia ka naʻau o ka insulin i ka wā e mālama ai me kahi agonist dopamine. Ua ʻike ʻia nā pae Prolactin e hoʻopili ʻia me ka estradiol, ka nui o ka testosterone, DHEAS, 17-hydroxyprogesterone a me nā pae cortisol i nā maʻi me PCOS. I loko o nā helu loiloi he nui, ua hoʻopili maikaʻi ʻia ka prolactin me ka estradiol, 17OHP, a me cortisol ma hope o ka hoʻoponopono ʻana no ka makahiki, BMI, a me ke kūlana ulaula. Ma nā haʻawina e pili ana i nā pūlehu holoholona, ​​loaʻa i ka prolactin ka hopena hōʻeuʻeu i ka hoʻomaikaʻi ʻia ʻana o nā pū adrenocortical, ka mea i hāʻawi ʻia i ka hyperplasia 31.6.

Eia kekahi, i ka manawa hou, me ka polycystic ovary syndrome, kahi pālahalaha o ka mālamalama a me ka metabolic hōʻailona. ʻO kekahi o kēia mau hōʻailona me ka chemocine migration inhibition factor (MIF), monocytic chemoattractant protein (MCP) -1 a me ka protein macrophage inflammatory (MIP), visfatin a resitin, a pēlā aku nā ʻikepili ma kēia mau mākē he hopena me ka hakakā, a me ko lākou koʻikoʻi i PCOS ke hoʻomau nei i kau ʻia.

No laila, ua hōʻike nā hopena o nā noiʻi he nui kekahi pilina ma waena o nā mālamaka maʻi, ke kū ʻana o ka insulin, a me ka maʻi polycystic ovary syndrome (Papa Palapala 1).

Pono nā haʻawina hou e hoʻoholo ai i kahi o nā māka e nānā pono i nā hana i kēlā me kēia lā e like me nā mea wānana o ka hoʻokolohua metabolic a me cardiovascular i nā maʻi me PCOS.

Hiki i nā hui ma waena o nā hōʻailona hōʻailona a me nā hōʻailona o ka nui o ka momona

Mass, insulin a me testosterone pae.

Nā hōʻailona hōʻailona i PCOS.

Kahi o nā māhina Level i PCOS im / fat mass Insulin sensitivity Testosterone

Hoʻohui ʻia ʻo Adiponectin (0 i,?

Grepn Ua ho'ēmi i t- (0

Hoʻemi ʻia Prolactin (V) 0) +

SCD36, oh-LDL Hoʻonui (0 + + ʻaʻole

Hoʻonui a CRP + + ʻAʻole

Leptin I loko o nā palena maʻamau + + (+) ʻaʻole

IL-6 Kahakaha + N / A

ka t, ka pilina kūʻokoʻa, pili haki,

+ + ikaika mau haʻahaʻa, + maikaʻi inter-modulus (t) pilina pili ʻole: ʻaʻohe pilina

KAUA MUA KEKAHI DANISHI. Endocrine a me ka metabolic hiʻohiʻona ma ka polycystic ovary syndrome. Dan med j

MOKUNA MOKUNA. Ka Hoʻopiʻi a me nā Hoʻoilina o ka Reproductive wahine

Ka Nūpepa o ka hopena endocrinology a me metabolism. Tian, ​​Ye, Zhao, Han, Chen, Haitao, Peng, Yingqian, Cui, Linlin, Du, Yanzhi, Wang, Zhao, Xu, Jianfeng, Chen, Zi-Jiang. Kauia Mei 1, 2016

Glintborg D., Andersen M. He hōʻano hou i ka pathogenesis, mumū a me ka metabolism ma ka hirsutism a me ka polycystic ovary syndrome. Gynecol Endocrinol 2010.4: 281-96

KAUA MUA KEKAHI DANISHI. Endocrine a me ka metabolic hiʻohiʻona ma ka polycystic ovary syndrome. Dan Med J 2016.63 (4): B5232

Eriksen M. B., Minet A. D., Glintborg D. et al. Hana pono mitochondrial hana i myotubes i hoʻokumu ʻia mai nā wahine me PCOS. J Clin Endocrinol Metab 2011, 8: E1298-E1302.

Ka Nūpepa o ka hopena endocrinology a me metabolism. Broskey, Nicholas T., Klempel, Monica C., Gilmore, L.

Anne, Sutton, Elizabeth F., Altazan, Abby D., Burton, Jeffrey H., Ravussin, Eric, Redman, Leanne M. Published June 1, 2017

Eriksen M., Porneki A.D., Skov V. et al. ʻAʻole mālama ʻia ke kūlohelohe Insulin i myotubes i hoʻokumu ʻia mai nā wahine me PCOS. PLOS IPAIMA 2010, 12: e14469.

Cibula D., Skrha J., Hill M. et al. ʻO ka wānana o ka naʻau o ka insulin i nā wahine nonobese me ka polycystic ovary. Iune 2016

ʻO Corbould A. Nā hopena o nā androgens i ka hana insulin i ka wahine: ʻoi aku ka nui o ka androgen he hapa o ka wahine metabolic syndrome? Diabetes Metab Res Rev 2008, 7: 520-32.

Maʻa ʻvlelo Koi (Polyinstic Ovarian maʻi) (Stein-Leventhal Syndrome) Lorena I. Rasquin Leon, Jane V. Mayrin. ʻO Ke Kauka Hou ʻo Einstein. Hoʻohui hou: ʻOkakopa 6, 2017

ʻO Neuroendocrine ka hoʻoponopono ʻana i ka meaʻai i ka Polycystic Ovary Syndrome. Daniela R., Valentina I., Simona C., Valeria T., Antonio L. Reprod Sci. 2017 Jan 1: 1933719117728803. doi: 10.1177 / 1933719117728803.

Morgan J., Scholtz S., Lacey H. et al. Ka nui o ka ʻai ʻana i nā kīnā i ka wahine me ka hirsutism o ke alo: he haʻawina cohort epide-miological. Int J Kai Kuokoa 2008, 5: 427-31.

KAOLE MANAU, KAKAKAKA, a OSTEOARTHRITIS. KE KAHANA LA ADIPOKINES: KA MEA KAHU ANA O LEVEE. Francisco V., Pérez T., Pino J., López V., Franco E., Alonso A., Gonzalez-Gay M.A., Mera A., Lago F., Gómez R., Gualillo O. J. Orthop Res. 2017 Oct 28.

Ka hana o ka adipocyte mitochondria i ka mumū, lipemia a me ka hoʻoweliweli ʻana o ka insulin i nā kānaka: nā hopena o ka pioglitazone

hana Xie X., Sinha S., Yi Z., Langlais P.R., Madan M., Bowen B.P., Willis W., Meyer C. Int J Obes (Lond). 2017 Aug 14. doi: 10.1038 / green.2017.192

Chen X., Jia X., Qiao J. et al. ʻO Adipokines i ka hana hana: ka pilina ma waena o ka obesity a me ka maʻi polycystic ovary syndrome. J Mol Endocrinol 2013, 2: R21-R37.

Li S., Shin H. J., Ding E. L., van Dam R. M. ʻO Adiponectin pae a me ka pilikia o ka maʻi type o ke ʻano 2: kahi loiloi ʻōnaehana a me ka meta-analysis. JAMA 2009, 2: 179-88.

Chen M.B., McAinch A.J., Macaulay S.L. et al. Hoʻomau i hana ʻia ka AMP-kinase a me ka hoʻoneʻe momona o ka hoʻonaninani ʻia ʻana e ka adiponectin globular i loko o ka ʻiwi māhuahua o ka ʻōpiopio o ka maʻi maʻamau i ka maʻi maʻamau. J Clin Endocrinol Metab 2005, 6: 3665-72.

ʻO Comim F.V., Hardy K., Franks S. Adiponectin a me nā mea ʻae ma loko o ka ʻākena: ʻoi aku ka hōʻike hou no ka pilina ma waena o ka momona a me ka hyperandrogenism ma polycystic ovary syndrome. PLOS ANA 2013, 11: e80416.

Otto B., Spranger J., Benoit S.C. et al. ʻO nā maka he nui o ka ghrelin: nāʻike hou no ka noiʻi ʻai? Br J Nutr 2005, 6: 765-71.

Hoʻomaʻamaʻa hoʻomaʻamaʻa a me ke kaumaha kaumaha, ʻaʻole i ka male mau i ka mare: ʻo ka hoʻomaʻamaʻa ʻōpiopio hoʻāʻo e hoʻomaʻamaʻa i nā wahine me nā BMI ʻokoʻa. Jackson M., Fatahi F., Alabduljader K., Jelleyman C., Moore J.P., Kubis H.P. Apanaa Physiol Nutr Metab. 2017 Nov 2.

Barkan D., Hurgin V., Dekel N. et al. Hoʻokomo ka Leptin i ka ovulation i nā kiʻina hema-GnRH. FASEB J 2005, 1: 133-5.

Jackson M., Fatahi F., Alabduljader K., Jelleyman C., Moore J.P., Kubis H.P. Apanaa Physiol Nutr Metab. 2017 Nov 2. doi: 10.1139 / apnm-2017-0577.

Gao S., Liu J. Chronic Dis Transl Med. 2017 May 25, 3 (2): 89-94. doi: 10.1016 / j.cdtm.2017.02.02.008. eCollection 2017 Jun 25. Review.

Onyango A.N. ʻO Oxid Med Cell Longev. 2017, 2017: 8765972. doi: 10.1155 / 2017/8765972. Epub 2017 Sep 7. Hōʻike.

Nakhjavani M., Morteza A., Asgarani F. et al. Hoʻopau ka Metformin i ka pilina ma waena o ka LDL serum-oxidized a me ka pae leptin i nā maʻi maʻi maʻi 2. Redox Rep 2011, 5: 193-200.

ʻO nā hui o ka Endotoxemia Me ka hoʻonāukiuki o nā Systemic, Endothelial activation, a me ka hopena Cardiovascular ma ka huina ʻana o nā keiki. Chan W., Bosch J.A., Phillips A.C., Chin S.H., Antonysunil A., Inston N., Moore S., Kaur O., McTernan P.G., Borrows R.J. Ren Nutr. 2017 Oct 28.

Diamanti-Kandarakis E., Paterakis T., Alexandraki K. et al. ʻO nā hiʻohiʻona o ka hoʻonāukiuki haʻahaʻa haʻahaʻa ma polycystic ovary syndrome a me ka hopena maikaʻi aʻe o ka metformin. Hum Reprod 2006, 6: 1426-31.

Bouckenooghe T., Sisino G., Aurientis S. et al. ʻO Adipose Tissue Macrophages (ATM) o nā poʻe maʻi luhi e hoʻokuʻu i nā kiʻekiʻe o ka prolactin i ka wā hoʻāliʻi: ʻO kahi kuleana no prolactin i ka diabesity? Biochim Biophys Acta 2013, 4: 584-93.

ʻO nā kumu Heterogenous o ka hyperandrogenism i ka maʻi ovary o ka polycystic ovima e pili ana i ka hui kino a me ka kūʻē o ka insulin. Patlolla S., Vaikkakara S., Sachan A., Ven-katanarasu A., Bachimanchi B., Bitla A., Settipalli S., Pathiputturu S., Sugali R.N., Chiri S. Gynecol Endocrinol. 2017 Oct 25: 1-5

KA INAHANAʻO NUI KAʻI A ME KA PONO A MAU I KE KĀLA HUI

Matsneva I.A., Bakhtiyarov K.R., Bogacheva N.A., Golubenko E.O., Pereverzina N.O.

ʻO Kulanui kenekulia mua o Moscow i kapa ʻia ma hope o I.M. Sechenov, Moscow, ka Russian Federation

Hoʻohālikelike. ʻO Polycystic ovarian syndrome (PCOS) kekahi o nā ʻano pinepine o ka endocrinopathies. ʻOiai ka lōʻihi o ka PCOS a me ka lōʻihi o ka manawa o ke aʻo ʻana, ʻo nā pilikia o ka etiology, pathogenesis, ka maʻi a me ka mālama ʻana i ka maʻi maʻi e hoʻomau wale nei. I nā makahiki i hala iho nei, ua loaʻa ka manaʻo o nā poʻe ʻepekema i ka nīnau o ke kōkua o ka hyperinsulinemia i ka hoʻolālā ʻana o PCOS. Ua ʻike ʻia ma 50-70% o nā hihia i hui pū ʻia ai PCOS me ka momona, hyperinsulinemia a me nā loli o ka lipid spra o ke koko, ka mea e hoʻonui ai i ka hiki ke hoʻomohala ʻana i nā maʻi cardiovascular, type II diabetes a alakaʻi i kahi ka hoʻemi ʻana o ka manaʻo maʻamau o ke ola. . ^ E Ha yM. ʻO ka nui o nā mea noiʻi e kuhikuhi ana i ka hoʻoholo genetic o nā hana kūlohelohe i PCOS, ka hōʻikeʻike i kahi e hoʻonui nuiʻia i mua o ka nui o ke kaumaha o ke kino. Hōʻike ka mana o kēia wā i ka hōʻike ʻana o ka pathogenesis o PCOS e ka hohonu noiʻi o ka hōʻino o ka metabolic: ka kū ʻana i ka insulin, ka hyperinsulinemia, ka huapalapala, hyperglycemia, dyslipidemia, ka hanana kulekahi, ka hoʻopaʻa ʻana i ko lākou hopena i ke ʻano o ke kaʻina pili i nā ovaries. , a me nā maʻi e pili ana i ka maʻi e like me ka insulin-kūleʻa mellitus kūwaho a me nā maʻi cardiovascular.

Hiki i kēia ke wehewehe i ka ʻimi no ka ʻike ʻana i kahi diagnostic hou e hoʻoholo ai i kahi o nā māka e hiki ke hoʻohana i loko o ka hana maʻamau i kēlā me kēia lā e like me nā poʻe wānana o nā kuʻuna metabolic a me cardiovascular i nā maʻi me PCOS.

ʻO nā huaʻōlelo nui: ke kū'ē i ka insulin, nā ʻōnaehana systemic, polycystic ovary syndrome, hyperinsulinemia, hyperandrogenia.

MOKUNA MOKUNA. Ka Hoʻopiʻi a me nā Hoʻoilina o ka Reproductive wahine

Ka Nūpepa o ka hopena endocrinology a me metabolism. Tian, ​​Ye, Zhao, Han, Chen, Haitao, Peng, Yingqian, Cui, Linlin, Du, Yanzhi, Wang, Zhao, Xu, Jianfeng, Chen, Zi-Jiang. Kauia Mei 1, 2016

Glintborg D., Andersen M. He hōʻano hou i ka pathogenesis, mumū a me ka metabolism ma ka hirsutism a me ka polycystic ovary syndrome. Gynecol Endocrinol 2010.4: 281-96

KAUA MUA KEKAHI DANISHI. Endocrine a me ka metabolic hiʻohiʻona ma ka polycystic ovary syndrome. Dan Med J 2016.63 (4): B5232

Eriksen M. B., Minet A. D., Glintborg D. et al. Hana pono mitochondrial hana i myotubes i hoʻokumu ʻia mai nā wahine me PCOS. J Clin Endocrinol Metab 2011, 8: E1298-E1302.

Ka Nūpepa o ka hopena endocrinology a me metabolism. Broskey, Nicholas T., Klempel, Monica C., Gilmore, L. Anne, Sutton, Elizabeth F., Altazan, Abby D., Burton, Jeffrey H., Ravussin, Eric, Redman, Leanne M. Published June 1, 2017

Eriksen M., Porneki A.D., Skov V. et al. ʻAʻole mālama ʻia ke kūlohelohe Insulin i myotubes i hoʻokumu ʻia mai nā wahine me PCOS. PLOS IPAIMA 2010, 12: e14469.

Cibula D., Skrha J., Hill M. et al. ʻO ka wānana o ka naʻau o ka insulin i nā wahine nonobese me ka polycystic ovary. Iune 2016

ʻO Corbould A. Nā hopena o nā androgens i ka hana insulin i ka wahine: ʻoi aku ka nui o ka androgen he hapa o ka wahine metabolic syndrome? Diabetes Metab Res Rev 2008, 7: 520-32.

Maʻa ʻvlelo Koi (Polyinstic Ovarian maʻi) (Stein-Leventhal Syndrome) Lorena I. Rasquin Leon, Jane V. Mayrin. ʻO Ke Kauka Hou ʻo Einstein. Hoʻohui hou: ʻOkakopa 6, 2017

ʻO Neuroendocrine ka hoʻoponopono ʻana i ka meaʻai i ka Polycystic Ovary Syndrome. Daniela R., Valentina I., Simona C., Valeria T., Antonio L. Reprod Sci. 2017 Jan 1: 1933719117728803. doi: 10.1177 / 1933719117728803.

Morgan J., Scholtz S., Lacey H. et al. Ka nui o ka ʻai ʻana i nā kīnā i ka wahine me ka hirsutism o ke alo: he haʻawina cohort epide-miological. Int J Kai Kuokoa 2008, 5: 427-31.

KAOLE MANAU, KAKAKAKA, a OSTEOARTHRITIS. KE KAHANA LA ADIPOKINES: KA MEA KAHU ANA O LEVEE. Francisco V., Pérez T., Pino J., López V., Franco E., Alonso A., Gonzalez-Gay M.A., Mera A., Lago F., Gómez R., Gualillo O. J. Orthop Res. 2017 Oct 28.

Ka hana o ka adipocyte mitochondria i ka mumū, lipemia a me ka hoʻoweliweli ʻana o ka insulin i nā kānaka: nā hopena o ka mālama pioglitazone. Xie X., Sinha S., Yi Z., Langlais P.R., Madan M., Bowen B.P., Willis W., Meyer C. Int J Obes (Lond). 2017 Aug 14. doi: 10.1038 / green.2017.192

Chen X., Jia X., Qiao J. et al. ʻO Adipokines i ka hana hana: ka pilina ma waena o ka obesity a me ka maʻi polycystic ovary syndrome. J Mol Endocrinol 2013, 2: R21-R37.

Li S., Shin H. J., Ding E. L., van Dam R. M. ʻO Adiponectin pae a me ka pilikia o ka maʻi type o ke ʻano 2: kahi loiloi ʻōnaehana a me ka meta-analysis. JAMA 2009, 2: 179-88.

Chen M.B., McAinch A.J., Macaulay S.L. et al. Hoʻomau i hana ʻia ka AMP-kinase a me ka hoʻoneʻe momona o ka hoʻonaninani ʻia ʻana e ka adiponectin globular i loko o ka ʻiwi māhuahua o ka ʻōpiopio o ka maʻi maʻamau i ka maʻi maʻamau. J Clin Endocrinol Metab 2005, 6: 3665-72.

ʻO Comim F.V., Hardy K., Franks S. Adiponectin a me nā mea ʻae ma loko o ka ʻākena: ʻoi aku ka hōʻike hou no ka pilina ma waena o ka momona a me ka hyperandrogenism ma polycystic ovary syndrome. PLOS ANA 2013, 11: e80416.

Otto B., Spranger J., Benoit S.C. et al. ʻO nā maka he nui o ka ghrelin: nāʻike hou no ka noiʻi ʻai? Br J Nutr 2005, 6: 765-71.

Hoʻomaʻamaʻa hoʻomaʻamaʻa a me ke kaumaha kaumaha, ʻaʻole i ka male mau i ka mare: ʻo ka hoʻomaʻamaʻa ʻōpiopio hoʻāʻo e hoʻomaʻamaʻa i nā wahine me nā BMI ʻokoʻa. Jackson M., Fatahi F., Alabduljader K., Jelleyman C., Moore J.P., Kubis H.P. Apanaa Physiol Nutr Metab. 2017 Nov 2.

Barkan D., Hurgin V., Dekel N. et al. Hoʻokomo ka Leptin i ka ovulation i nā kiʻina hema-GnRH. FASEB J 2005, 1: 133-5.

Jackson M., Fatahi F., Alabduljader K., Jelleyman C., Moore J.P., Kubis H.P. Apanaa Physiol Nutr Metab. 2017 Nov 2. doi: 10.1139 / apnm-2017-0577.

Gao S., Liu J. Chronic Dis Transl Med. 2017 May 25, 3 (2): 89-94. doi: 10.1016 / j.cdtm.2017.02.02.008. eCollection 2017 Jun 25. Review.

Onyango A.N. ʻO Oxid Med Cell Longev. 2017, 2017: 8765972. doi: 10.1155 / 2017/8765972. Epub 2017 Sep 7. Hōʻike.

Nakhjavani M., Morteza A., Asgarani F. et al. Hoʻopau ka Metformin i ka pilina ma waena o ka LDL serum-oxidized a me ka pae leptin i nā maʻi maʻi maʻi 2. Redox Rep 2011, 5: 193-200.

ʻO nā hui o ka Endotoxemia Me ka hoʻonāukiuki o nā Systemic, Endothelial activation, a me ka hopena Cardiovascular ma ka huina ʻana o nā keiki. Chan W., Bosch J.A., Phillips A.C., Chin S.H., Antonysunil A., Inston N., Moore S., Kaur O., McTernan P.G., Borrows R.J. Ren Nutr. 2017 Oct 28.

Diamanti-Kandarakis E., Paterakis T., Alexandraki K. et al. ʻO nā hiʻohiʻona o ka hoʻonāukiuki haʻahaʻa haʻahaʻa ma polycystic ovary syndrome a me ka hopena maikaʻi aʻe o ka metformin. Hum Reprod 2006, 6: 1426-31.

Bouckenooghe T., Sisino G., Aurientis S. et al. ʻO Adipose Tissue Macrophages (ATM) o nā poʻe maʻi luhi e hoʻokuʻu i nā kiʻekiʻe o ka prolactin i ka wā hoʻāliʻi: ʻO kahi kuleana no prolactin i ka diabesity? Biochim Biophys Acta 2013, 4: 584-93.

Insulin-pale type o PCOS

Puka ʻano maʻamau o PCOS a ma o ka lōʻihi o ka mea i ʻike ʻia. Mea kiʻekiʻe insulin a leptin kāohi i ka ovulation a hoʻoulu i nā ovaries i intensively synthesize testosterone. ʻO ke kūlohelohe i ka inaluna e hoʻoneʻe ʻia e ka koko, ka uahi, ka contraceptives hormonal, nā momona trans a me nā meaʻala o nā kaiāulu.

ʻO nā maʻamau maʻamau ʻO ke kumu o ka PCOS ka pilikia nui me ka insulin a me ka leptin.Insulin hoʻokuʻu ʻia mai i kāu pancreas. Leptin hoʻokuʻu ʻia mai kāu momona. Hoʻopili, ua mālama kēia mau lua ʻelua i ke kō koko a me ka makemake. Hoʻopaʻa lākou i nā hormone wahine.

Kū ala ʻia ka Insulin ma hope o ka ʻai ʻana, ka mea e hoʻoulu ai i kāu mau cell e komo i ka glucose i kou koko a hoʻohuli i ka ikehu. A laila ua hina. ʻO kēia ka mea maʻamau inā "āu hoʻonaninani o ka insulin."

ʻO ka Leptin kāu hormone satiety. Ke ala nei ʻo ia ma hope o ka ʻai ʻana, a inā pū me kou momona. Ua kamaʻilio Leptin i kāu hypothalamus a kamaʻilio e pili ana i ka hoʻohaʻahaʻa i kou makemake a hoʻonui i ka hopena metabolic. Ua haʻi aku ʻo Leptin i kāu lepiha laupiha e hoʻokuʻu i ka FSH a me LH. ʻO kēia ka maʻamau ke "hoʻomaopopo i ka leptin."

Ke nānā ʻoe i ka insulin, he haʻahaʻa ʻoe a me ka liʻiliʻi o ka insulin i kāu helu ʻai wikiwiki. I ka ʻike ʻana i ka leptin, he leptin maʻamau haʻahaʻa.

I ka hihia o PCOS, ʻaʻole ʻoe i ʻike i ka insulin a me ka leptin. Kūʻē ʻoe iā lākou, ʻo ia ka mea hiki ʻole iā ʻoe ke pane pololei i loko o lākou. ʻAʻole hiki i ka Insulin ka ʻōlelo e hoʻopau kāu mau cell i ka glucose no ka ikehu, no laila e hoʻohuli ʻo ia i ka glucose i ka momona. ʻAʻole hiki i Leptin ke haʻi i kou hypothalamus e hoʻopau i ka makemake, no laila ua pōloli ʻoe i nā manawa a pau.

I ka wā āu ke kū'ē i ka insulin, he kiʻekiʻe nā kiʻekiʻe o ka insulin. A ʻai ka pale aku i leptin, he leptin kiʻekiʻe. Me kēia ʻano PCOS iā ʻoe i ka insulin a me ka pale pale leptin - ua kahea ia Ke kū'ē i ka insulin.

Ke hoʻonāukiuki ʻia ka hoʻonāukiuki ma mua o PCOS. Hiki i ka wahine ke loaʻa nā menstruation kaumaha (menorrhagia), nā kaiha, ka hakihaki, ka nui o ka progesterone, a me ka makemake e hoʻonui i ke kaumaha. Ke hoʻonui nei ka pilikia o ka hoʻomohala ʻana i ka maʻi diabetes, cancer, osteoporosis, dementia, a me ka maʻi puʻuwai. ʻO ia ke kumu e hoʻonui ai ka PCOS i ka hopena o kēia mau kūlana.

Nā kumu kumu o ke kūmole

ʻO ke kumu maʻamau o ka pale ʻana i ka insulin o ke kō, ʻo ia ka mea e pili ana i ka fructose i loko o nā mea ʻono a me nā mea momona hoʻāʻo. Palapala i ka fructose (akā, ʻaʻole i emi iho ka hopena fructose) e hoʻololi i ke ʻano o ka lolo i ka leptin. Hoʻololi kēia i ke ʻano o ka hopena o kou kino i ka insulin. Hoʻokumu pū ka fructose i kāu ʻai hou aʻe, kahi e alakaʻi ai i ka paona.
Aia kekahi mau kumu kūpono no ka pale ʻana o ka insulin. ʻO nā mea nui: predisposition genetic, ulaula, trans momona, hoʻāʻeha, pills control mana, moe moe, moeʻuhane o ka magnesium (kūkākūkā ma lalo) a me nā meaʻala kino kaiapuni. Hōʻalo kēia mau mea i ka pale ʻana o ka insulin no ka mea e hōʻino lākou i kāu mea i hoʻohuihui i ka insulin, a me ka hopena, ʻaʻole hiki ke pane pololei.

ʻO ke kaʻina o ka hōʻemi ʻana i ka ʻike palia i ka insulin

I ka wā o ka hoʻohana ʻana i nā contraceptives hormonal, ʻokoʻa synthetic, ʻokoʻa mai ka ʻike ʻana o ko lākou mau pono ponoi iho, hāʻawi mau ʻia i ke kino o kahi wahine ʻōpiopio i loko o kahi nui. Ma hope o ka hoʻopili ʻana, ʻaʻole e loaʻa ka hopena o kā lākou hormones i ke hana i nā kuli endocrine. Ka luhi o ka hoʻoponopono ʻana o ka ʻōnaehana endocrine i ka hopena.
A i ola ke kino, kūloko o nā kino āpau lilo i mea ʻole i nā hormone āpau, me na insulin.

No ke aha ke ʻano kino o ka insulin?

He mea koʻikoʻi ka pili o nā ʻili a me nā ʻōpala i ka insulin. E hoʻoholo ana i ke komo ʻana o ka pona o ka glucose a me nā mea momona ʻē aʻe. ʻO ka mea maoli, ua pōloli ka pōloli me ka insulin a me ka glucose no ke kino. ʻO ka mea hoʻohana nui o ka glucose ka mōʻī, ʻaʻole ia e hana maʻamau me ka ʻole o ka hana.
No ka laʻana, i nā mea maʻi me ka maʻi mellitus o ka maʻi mellitus, me kahi kao nui o ka glucose, hiki i ka cortex cerebral ke make i loko o kahi mau minuke (hypoglycemic state). I mea e pale ʻole ai i kēlā ʻano pilikia, hānai mau nā mea maʻi me ka maʻi maʻi i kekahi mea momona me lākou.
E hoʻomaka ka pancreas e synthesize i ka insulin ma kahi hoʻomau mau a ma ka pā kula.i mea e pale ai i ka make lolo. No laila hiki ke hoʻomaka diabetes type 2 - he pilikia a maʻi ka maʻi.

No laila, inā lawe ka wahine i ka OK, a laila ka hoʻemi ʻana a me ka ʻike pono ʻana i ka insulin. ^ E Ha yM. ʻO kēia kekahi o nā hoʻopiʻi nui i ka wā e hoʻohana ai i nā hormone synthetic. Hoʻonui nui ka hana insulin pancreas. Hoʻohāukiuki ka nui o nā insulin i kahi ʻano o nā hana metabolic a me ka endocrine, a hiki i ka hoʻomohalaʻana i ka maʻi type 2. Hele wale nō ia loli ka hopena i loko o nā ovaries - lilo lākou i hypersensitive i ka insulina laila e like nō ka hopena - wale nō me ka maʻi ʻole o ka maʻi maʻi.

ʻOi aku ʻO OK e pale i ka loaʻa ʻana o ka maʻa i nā wahine'ōpio. Hiki i kēia ke hōʻeha i ka paona a me ka emi ʻana o ke ʻano o ka naʻau o ka insulin, no laila nā koho hoʻohālikelike hormonal kahi koho maikaʻi ʻole ʻia no ka PCOS.

He aha ka pili o ka insulin i nā ovaries?

I nā ovaries, ua syntesize nā androgens, mai kahi i hana ʻia ai ka estrogens. Hoʻolāla ʻia ke kaʻina hana iā ia iho i ka insulin. Inā kiʻekiʻe kona mau kiʻekiʻe, a laila hoʻomau nui ʻia nā hormone ovarian a pau i loko o nā ovaries.
ʻO ka huaʻai hope ʻo Estrogens ka hopena hopena o ka kaulahao kūloko. Nā huahana waena - progesterone a me androgens o nā ʻano like ʻole. Hāʻawi lākou i ka nui mau hōʻailona leʻaleʻa ma PCOS.

Ka nui o ka insulin - ka nui o nā androgens i loko o nā ovaries

Hoʻololi ka nui o nā insulin i nā ovaries e synthesize androgens i ka nui. A ʻo ka wahine ʻōpiopio ma mua o ka loaʻa i nā leʻaleʻa a pau o ka hyperandrogenism: huehue, poho lauoho, hirsutism.

Hōʻike testosterone (hormonen adrenal), kapa ʻia ʻo ia ka "male" hormon, 99% aia i loko o ke kino wahine i kahi ʻano hana ʻole, huki ʻia e kahi protein nui (SHBG, SHBG). Huli ka Testoster i kahi ʻano hana - dihydrotest testosterone (DHT, DHT) me ke kōkua ʻO ka insulin a me ka 5-alpha reductase enzyme. ^ E Ha yM. ʻO ka maʻamau, ʻaʻole nui o DHT ma mua o 1%.
Hāpai ʻo Dihydrotestosterone e hōʻiliʻili i nā follicle lauohoe hoʻokau ʻana i ka pilikia nui no ka hiʻohiʻona o ka wahine: lilo ka lauoho i ka palauwili, ʻāwili a hoʻomaka ke hāʻule ʻana i lalo, ma muli o kahi hopena e hiki ai i ka ʻōhule.
ʻO kekahi hapalua hoʻi o DHT i loko o ke koko e hoʻopilikia pū me ka ʻili: ʻoi aku ka nui o ka momona momona, nā aʻa. A hele ka ʻolua a huli hoʻi ka metabolism.

ʻO ka mea hope loa, he nui ka insulin Hoʻokomo i kou keliʻi pituitary e synthesize ʻoi aku ka luteinizing hormone hou (LH), kahi e hoʻoulu hou ai i ka androgens a me nā poloka o ka ovulation.

No laila, he kiʻekiʻe ka kiʻekiʻe o ka insulin i ke koko hoʻonui i nā manaʻo i nā androgens hoʻoikaika. Hoʻolima ʻo Androgens ʻaʻole i loko o nā ovaries wale nō, akā hiki nō i nā kelepa adrenal, nā pepona, nā pēpē, a me nā kiko adipose. Akā ʻo nā ovaries ka pilina nui loa i ka hoʻomohala ʻana o ka PCOS.

ʻO nā hawewe-Apple ʻona

E makaʻala i ka hōʻailona pilikino o ke kau momona i ke ʻano o kahi ʻōpala (e lawe ana i ka paona nui ma mua o kou ʻāʻī.
E hoʻohana i kahi ana lipine e hoʻopaʻa i kou ʻāʻī ma ke poʻo. Inā ʻoi aku ka nui o kou mau ʻūhā ma mua o 89 cm, a laila he maʻi ʻokoʻa ka kū i ka insulin. Hiki ke helu pono i kēia ma ke ʻano o ka pilina o ka ʻūhā i ke kiʻekiʻe: Pono e pale i kou ʻōpū ma lalo o ka hapalua o kou kiʻekiʻe.
ʻO ke kaupaona ka Apple he hōʻailona hōʻailona o ka pale ʻana o ka insulin. ʻOi aku ka nui o kou ʻūhā, ʻoi aku ka nui o kou PCOS i kahi ʻano kūlia insulin.

ʻO ka insulin kiʻekiʻe ka mea paʻakikī ka kaumahaa hiki i kēia ke lilo i ka pōʻino wela: ʻo ka momona o nā mea hoʻonāukiuki i ka insulin, e hoʻonāukiuki i ka hakihiki, kahi e hoʻomau i ka pale ʻana i ka insulin. ʻO ka hoʻolālā maikaʻi kaui maikaʻi loa ka hoʻoponopono ʻana i ka pale ʻana o ka insulin.

Nui! Hiki i ke kūloʻi insulin ka mea i hiki i ka poʻe i loko o ka poʻe. Pono ʻia kahi hoʻokolohua koko.

ʻO ke ʻano koko no ke kū ʻana i ka insulin

E noi i kāu kauka i nā kuhikuhi i kekahi o nā koho hoʻokolohua:

• Hōʻike no ke ahonui glucose a me ka insulin.
  Me kēia hoʻokolohua, hāʻawi ʻoe i kekahi mau helu koko (ma mua a ma hope o ka inu ʻana i kahi mea momona). Hōʻalo ka hōʻike iā ʻoe i ka wikiwiki o ka hoʻomaʻemaʻe ʻana i ka glucose mai ke koko (e hōʻike ana i kahi pane maikaʻi i kāu insulin). Hiki iā ʻoe ke hoʻāʻo i ka leptin, akā ʻaʻole ka hapa nui o nā laboratories.
• Hōʻike koko ma lalo o ka helu HOMA-IR.
  ʻO ka hoʻohālikelike ma waena o ka insulin ʻaʻa wikiwiki a me ka glucose wikiwiki. ʻO ke kumu kiʻekiʻe o ka insulin ka mea e pale ai ka insulin.

Inā loaʻa iā ʻoe ke kūleʻa o ka insulin, pono ʻoe i nā lāʻau e kūkā ai mākou ma hope aʻe.

Ka hōʻole ʻia o ke kō

ʻO ka mea mua e hana ai e hoʻopau i ka ʻai ʻaina a me nā mea inu momona. Ua ʻoluʻolu wau i ka mea nāna e lawe i ka lono maikaʻi, akā ke hoʻōki nei au. ʻAʻole au e ʻōlelo e hoʻi wale ana i ka pie. Inā kū ʻoe i ka insulin, ʻaʻohe āu e loaʻa ai i "hormonal" noʻu e hoʻomoʻa i ka ʻono. I kēlā me kēia manawa e ʻai ʻoe i ka mea ʻono, e paipai iā ʻoe a hohonu aʻe hoʻi i ka pale ʻana o ka insulin (a hohonu hoʻi i loko o ka PCOS).
ʻIke wau he paʻakikī ke haʻalele i ke kō, ināʻoi aku inā kaukaʻina ʻoe. ʻO ka hāʻawi ʻana i ke kōʻai hiki ke maʻalahi a maʻalahi hoʻi ma mua o ka haʻalele ʻana. ʻO ka weheʻana i ke kō mai ke kino e koi i kahi hoʻolālā akahele.

Pehea e hoʻoikaika ai i ke kaʻina o ka hōʻole i ke kō:

• Loaʻa ka hiamoe nui (no ka mea ke hiamoe i ka hiamoe ke kumu o ka cravings gula).
• Eʻai i nā meaʻai piha pono e pili ana i nā ʻekolu macronutrients: ʻona, kōpana, a me ka momona.
• Mai ho'āʻo e kaupalena i kāu meaʻai i nā ʻano meaʻai ʻē aʻe i ka wā e hoʻolei ana i ke kō.
• E hoʻomaka i kahi papaʻai i ka wā haʻahaʻa haʻahaʻa i kou ola.
• E makaala e nalowale ana nā kuko ikaika no nā lepe i 20 mau minuke.
• E hoʻomaopopo i ka minamina pinepine ʻia i loko o nā hebedoma ʻelua.
• Hoʻohui i ka magnesium no ka mea e hōʻemi i nā cravings gula.
• E aloha iā ʻoe iho. E kala iā ʻoe iho. E hoʻomanaʻo, ua hana ʻoe iā ʻoe iho!

ʻOkoʻa ka hāʻawi ʻana i ke kō i ka meaʻai liʻiliʻi. I ka ʻoiaʻiʻo, ʻoi aku ka maʻalahi o ka hāʻawi ʻana i ke kō inā ʻaʻole ʻoe e pale i ka mākēkē, e like me ka ʻuala a me ka laiki, no ka mea hoʻihoʻi nui ka mōʻī i nā cravings. Ma kahi ʻaoʻao ʻē aʻe, ʻoi aku ka paʻakikī o ka haʻalele ʻana i ka hānai inā e ʻai ʻoe i ka meaʻai maʻi e like me nā palaoa a me nā huahana waiana. ʻO kēia no ka mea maʻamau nā meaʻai meaʻai i nā hōʻailona maʻamau o nā meaʻai aʻai.
E hiki mai ka manawa e hana maʻamau ai kāu insulin a laila hiki iā ʻoe ke hauʻoli i kahi kaila manuahi. Maʻalahi loa, ʻo wau kahi manawa hoʻokahi i ka malama.

Nā hoʻomaʻamaʻa

Hoʻomaʻamaʻa mau ka hoʻomaʻamaʻa i ka ʻiʻo i ka insulin. I ka ʻoiaʻiʻo, he mau hebedoma ikaika o ka hoʻomaʻamaʻa ʻana i hōʻike i ka nui o ka naʻau o ka insulin o 24%. E hele inoa i kahi ʻenehana, ʻoiai me kahi liʻiliʻi ʻoi aku ʻoe e ʻike hou ai i kahi hoʻomaikaʻi. E hele a puni ka poloka. E piʻi i nā ʻōpū. Koho i ke ʻano o ka hoʻomaʻamaʻa āu e makemake ai.

KĀNANA NO KA MANA NOHO NO KA ʻĀNUI

Hoʻolālā ʻia ka regimen ʻaʻole e hoʻonui wale i ka naʻau o ka insulin i nā wahine me PCOS, akā no ka poʻe āpau i kiʻekiʻe i ka maʻi diabetes.

Magnesium taurate

Berber *

Inositol Powder, 227 g

Maika GTF

Nā wahi pakuhi

* Berberine mai hui pū i nā lāʻau lapaʻau ʻē aʻe: antidepressants, beta blockers, a i ʻole immunosuppressants (no ka mea hiki ke hoʻololi i ke koko o kāu mau lāʻau lapaʻau). Contraindicated i ka wā hāpai a me ka lactation.
Mai hoʻohana pinepine mau ma mua o ʻekolu mau mahina no ka mea he antimicrobial a hiki ke hoʻololi i ka hoʻonohonoho ʻana o nā maʻi o ka huina. Hoʻohuli iā 3 mau mahina me ka berberine me curcumin.

** ʻAka Lipoic Lipoic palekana maʻamau, akā ma nā inika kiʻekiʻe (ʻoi aku ma mua o 1000 mg) hiki iā ia ke hoʻohaʻahaʻa i nā hormone thyroid.
ʻO ka waiona Alpha-lipoic, he thiol, ʻaʻole ia e hui pū me ka vitamin B12, no ka mea loaʻa pū lākou i ka hopena antitumor, akā lilo i mea olakino i ke kino o ke kanaka olakino. No laila, inu ʻokoʻa mākou i nā lāʻau lapaʻau i kahi i kū ai ka B12, ma ke ʻano he papa ʻaina (ʻaʻole hiki iā mākou ke hāʻawi iā lākou i ke ao).
Lawe i kahi kaʻawale mai ka magnesium, ka hao a me ka calcium, ʻoiai komo i loko o kahi ʻano me lākou, i loko o ka ʻai ʻē aʻe, mai hui pū me ka waiʻona.

*** Kauahi Chrome mai hui pū me nā antidepressants, beta-blockers, H2 blockers, proton pump inhibitors, corticosteroids, NSAIDs.

Progesterone

ʻO ka paleʻana i ka insulin he kumu no ka hemahema o ka progesterone a me nā nui kaumaha.
ʻO ka pilikia kumu nui me PCOS ka nele o ka synthesis o progesterone no ʻelua pule i kēlā me kēia mokulā. ʻO ka hemahema o ka progesterone e alakaʻi i kahi hemahema i loko o ovaries, hoʻoikaika i nā androgens, a alakaʻi i nā lehelehe i ʻole. I kēlā manaʻo e hoʻoponopono i kēia kaulike ma ka hoʻāla hou ʻana i ka progesterone (ma mua o ka duphaston), hāʻawi wau i 2 i koho e koho ai:

ʻĀnō Nāʻaina, Nā Pele Progesterone Kumuhana

• me kahi neʻe maʻamau o ka menstrual - hoʻomaka mai ka 14 a 25 mau lā o MC (ka lā mua o ka ʻūhū ʻana i kaʻaila pono e pili me ka lā o ovulation.)
• i ka hala ʻana o kahi pōkole - kau i nā lā 25 me kahi hoʻomaha o 5 mau lā.
• me ka progesterone haʻahaʻa a i ʻole testosterone kiʻekiʻe loa - e hoʻopili i ka malama mua i ka hoʻomau, a mai ka wā aʻe - i ka lua o ka hana.

GUNA, Potentiated Progesterone Drops

E ʻike ʻia kahi hopena lōʻihi ma hope o 1 mahina o ka hoʻohana.
Ke ʻano o ke hoʻohana ʻana:
Ma ka 20 hāʻule i 2 mau manawa i kahi lā ma kahi ʻōpū ʻāwā 20-30 mau minuke ma mua o ka ʻai ʻana i hoʻokahi hola ma hope o ka ʻai ʻana, e hoʻohana ai i kēia hoʻolālā:

• me kahi neʻe maʻamau o ke kāne - hoʻomaka mai ka 14 a 25 mau lā o MC (ka lā mua o ke komo ʻana e pono me ka lā o ovulation.)
• i ka hala ʻana o kahi pōkole - lawe i 25 mau lā me kahi wā o 5 mau lā.
• me ka progesterone haʻahaʻa a i ʻole testosterone kiʻekiʻe loa - e hoʻopili i ka malama mua i ka hoʻomau, a mai ka wā aʻe - i ka lua o ka hana

Hōʻike ʻia ka progesterone potentiated no ke hoʻohana ʻana me indoger progesterone inducer - GUNA ALOHA (G3)no laila ke hoʻomau nei ke kino i kēia hana.
Ma ka 20 hāʻule i 2 mau manawa i kahi lā ma luna o kahi ʻōpū o 20-30 mau minuke ma mua o ka papaʻaina a i hoʻokahi hora ma hope, e hoʻomau mau no ka mahina. Hiki ke hoʻohui ʻia nā lāʻau ʻelua i loko o kahi kīʻaha wai a inu lohi.

• I kūʻai Progesterone Guna ma eBay me ka hoʻokele honua
• I kūʻai ʻO Guna Palaka ma eBay me ka hoʻokele honua

Hoʻomaka ka hoʻomākaukau ʻana ʻo Progesterone ma ka inika insulin no nā mahina 3-4.

Hiki i ka Hyperandrogenism ke alakaʻi i ka hyperestrogenism a i ʻole nā ​​wīwī i ka hemahema o estrogen.
I kahi hihia o ka emi ʻana o ka synthen estrogen, hoʻohui mākou i ka hoʻohui phytoestrogens a i ʻole ka haneli estrogens paha koho ana.
ʻO Phytoestrogens keʻano like me ke kanaka o ka estrogen, akā, ma ke ʻano he kānāwai, nāwaliwali loa. Loaʻa i nā mea kanu Phytoestrogenic nā pūhui like ʻole, kēlā me kēia, e pili ana i ke kino ma nā ʻano like ʻole. Hiki iā lākou ke lawe mai i nā pōmaikaʻi hou o ke olakino: mālama i ka pale ʻana, hoʻomaikaʻi i ka kaʻe ʻana o ke koko i ka pelvis, hoʻēmi i ka maʻi ʻaʻa, etc.

Ke Alanui o ke ʻano, Red Clover

• me kahi manawa kūlohelohe maʻamau - hoʻomaka mai 5 a 14 mau lā o MC
• Inā ulu maikaʻi ka endometrium, a laila mai 5 a 25 lā no ka MC

GUNA, Potentiated Estradiol Drops

• me kahi neʻe maʻamau o ke kāne - hoʻomaka mai ka 14 a 25 mau lā o MC (ka lā mua o ke komo ʻana e pono me ka lā o ovulation.)
• Inā ʻaʻole e ulu maikaʻi ka endometrium - mai 5 a hiki i 25 mau lā o MC

Hoʻoikaika ʻia ka estradiol no ka hoʻohana ʻana me Pūnaewele Inoa ʻO estradiol - GUNA FEM, nāna e hoʻopuni i ka ʻōnaehana endocrine holoʻokoʻa a me ke kino ponoʻī i kēia kaʻina hana.
Ma ka 20 hāʻule i 2 mau manawa i kahi lā ma luna o kahi ʻōpū o 20-30 mau minuke ma mua o ka papaʻaina a i hoʻokahi hora ma hope, e hoʻomau mau no ka mahina. Hiki ke hoʻohui ʻia nā lāʻau ʻelua i loko o kahi kīʻaha wai a inu lohi.

Loaʻa nā homa homopona homeopathic no Ukraine wale nō, no ka mea minamina ʻole lākou i hāʻawi pololei ʻia i nā mea hana mai Rusia. Ua hoʻomaka kekahi mau lāʻau lapaʻau ma Amazon.

• I kūʻai Guna fem ma eBay me ka hoʻouna moku honua.
• I kūʻai Guna estradiol ma eBay me ka hoʻouna moku honua.

E waiho i kahi kauoha i ka hale kūʻai o Ukrainian distributor o Guna, pono ʻoe i kahi helu palapala o ka loea i hoʻomaʻamaʻa ʻia me lākou - 1781 (Hiki ke holoi ʻia ka inoa piha). Hoʻolaha ʻia ka lawe ma waena o Ukraine ma ka leka uila hou, kālā ma ka hoʻopuka.