Nā hopena o ka hoʻohana ʻana i ka sibutramine

ʻO ka ʻokoʻa ka hiki ʻana o ka metformin i loko o nā papa, he nui ka hoʻēmi ʻana a me nā waiwai momona.

No laila, ua kuhikuhi ʻia ka lāʻau lapaʻau i ka mālama ʻana i ka momona, i hoʻouka ʻia me ka maʻi diabetes.

ʻO kahi mea e uku kūpono ai no reduxin.

ʻO ka mea hana he waika linoleic, e hoʻōla maikaʻi ana i ke kaʻina hoʻoneʻe ʻana i ka momona.

Wahi a nā loiloi o ka pohō kau kaumaha, ʻoi aku kēia mau paila i ka hoʻohaʻahaʻa ʻana, a ʻoi hoʻi ka wikiwiki o ka momona.

ʻO ia ka mea kikowaena maikaʻi loa o ka reduxin mai kahi mea hana huahana.

Hoʻokuʻu i nā puka - nā papa, nā mea āpau, nā mea ʻoniʻoni, nā ʻili, nā hui, nā puna, nā teas, nā granule, nā lole ʻuma.

He pani pani kokoke no ka kukui reduxin.

E like me ke noi ʻana o nā mea hana, hoʻomaikaʻi ka turboslim i ka ʻōnaehana nūhou, e hoʻomaikaʻi ana i ke kaʻina o ke kūnaʻi ʻana, a e hoʻomaikaʻi i ka pale ʻana.

Nā mea hoʻohalike o Ukrainian

I waena o nā lāʻau lapaʻau o ka hana o Ukraine, hiki iā ʻoe ke loaʻa hoʻi i ka lāʻau lapaʻau e kōkua e pane i ka nīnau no ka mea e hoʻohuli ai i reduxin me ka.

• Styfimol . ^ E Ha yM. E hoʻokuʻu i nā puka - nā ʻopi. ʻO ka ʻāpana pill maʻamau ka Garcinia Cambogia Extract, kahi i ʻike lōʻihi ʻia no kāna hana meaʻai. ʻO ka lawe ʻana i ka lāʻau lapaʻau e hōʻemi i ka kolamu, hoʻēmi i ka momona, a hoʻoponopono i kaʻohi glucose. ʻO ka kumukūʻai kumukūʻai ʻo 560-750 rubles.

Generics Belarusian

Aia ka papa i kahi papa inoa o ka Belarusian generu reduxin, i hoʻohana nui ʻia i ka mālama ʻana i ka momona, a i ʻole i kahiʻaoʻao o nā ana no ka nalowale i ke kaumaha.

ʻO nā kaulike'ē aʻe ʻē aʻe

Hiki ke loaʻa i nā mea hoʻohui ʻia o kēia mau lā i ka reduxin ma ke ʻano o nā lāʻau lapaʻau, a me nā mea kūʻai nui. E noʻonoʻo i ka mea pono nui o lākou.

• Lindax . ^ E Ha yM. Hoʻolālā ʻia ka lāʻau lapaʻau Anorexigenic e hoʻoikaika i ka manaʻo o ka piha. ʻO ka'āina kahi - Czech Republic. ʻO ka awelika kumukūʻai he 1700-6800 rubles.
• Slimia . ^ E Ha yM. Hana ʻia ka lāʻau lapaʻau ma India. ʻO kaʻelima maʻalahi loa ka hopena o ka reduxin. Hana ʻia ia ma ke kumu o ka sibutramine a loaʻa i nā capsules. Hoʻohana wale ia no nā kumu olakino ma ka mālama ʻana i ka momona. ʻO ka kumu kumukūʻai o 140-350 rubles.
• Meridia . ^ E Ha yM. ʻO ka lāʻau e hōʻemi i ke kaumaha o ke kino, hana ma ke ʻano he hoʻoponopono regalona. ʻO ka'āina mai - Kelemānia. ʻO ka awelika kumukūʻai he 2500–3500 rubles.
• Zepuia . ^ E Ha yM. ʻO ka hopena no ka momona. ʻO ka'āina mai - Polani. ʻO ka kumukūʻai kumukūʻai ʻo 1800-2500 rubles.
• Mālama . ^ E Ha yM. Loaʻa ka huahana i ke ʻano o nā kapsul. No nā hui o nā anorexigens. ʻO ka'āina kahi - India. ʻO ka awelika kumukūʻai he 780–950 rubles.

ʻO Sibutramine a me kona mau mea hoʻohui i nā mea psychotropic ikaika e hiki ai ke pale i ka pūnao o ka hale waena. Ke kumu o ka hopena ncotic, hiki i kēia mau papa ke hōʻeha i ka hilinaʻi i nā mea maʻi.

Aia kekahi mau hiʻohiʻona e make ma hope o kahi kūʻokoʻa kūʻokoʻa o kēia mau lāʻau i mea e hoʻohemo ʻia ai ke kaumaha ʻo "ka nui".

Eʻoluʻolu e pili ʻole ka lawe ʻana i nā lāʻau anorexigen me ka pahuhopu aesthetic o ke kaumaha koʻikoʻi. Hiki ke hoʻohana ʻia i nā lāʻau hoʻopau i ka momona e hoʻomaʻamaʻa i ka momona, e like me ke kauoha a ke kauka.

Ua hoʻāʻo mua ʻia ʻo Sibutramine e hana i mea no ka hōʻeha ʻana i ke kaumaha, akā naʻe, ʻaʻole i loaʻa kahi hopena maikaʻi. Akā i ka wā o ka hoʻokolohua, ua ʻike ʻia kona hiki ke hoʻohiolo. Mai ia manawa, ua hoʻohana ʻia nā sibutramine. Nui nā mau ʻāina i pāpā ʻia ai ka lāʻau. No laila, ua kāpae ʻia ka hāʻawi ʻana i nā ʻāina CIS.

ʻO ka hoʻohanaʻana i ka lāʻau lapaʻau ka hopena paha i nā hana ʻē aʻe no ka lilo ʻana o ka paona i hāʻawi i kahi hopena. Hoʻohana ʻia ka Sibutramine i ka hui pū me ka hana a me ka hana kino. No laila e loaʻa mai ai nā hopena hou aʻe:

• ʻOhi ʻaū
• Hoʻomaka kūlohelohe i ka momona kino,
• Ka hana ana o ka hana serotonin, e kōkua ana i ka maikaʻi leo,
• Hoʻemi i ka salivation a me ka mākaukau e hoʻomohala i nā ʻoka,
• Ma ka hopena o ka hopena maikaʻi, hōʻemi ka paona mai 7 a 15 kg i ka malama.

He aha nā lāʻau lapaʻau e loaʻa ai?

Aia kekahi mau lāʻau lapaʻau e loaʻa ai nā sibutramine, eia kekahi o lākou:

• Meridia (hana Kelemānia),
• Lindaksa (hana Ceko),
• Reduxin (hana i Lūkia),
• , Sliema (hana ʻana i India).

ʻO kēia mau lāʻau āpau ua loaʻa i ka sibutramine a me nā lāʻau lapaʻau kōkua ʻē aʻe. Loaʻa iā Sibutramine nā analogue, hoʻohālikelike lākou i ka hoʻemi ʻana i ke kaupaona, akā ua palupalu ko lākou hopena ma ke kino a ʻaʻole ʻino. Nā papa like: denfluramine, dexfenfluramine, lorcaserin. I waena o nā mea kikoʻī e hoʻohālikelike ai i ka hōʻemi hou o ka serotonin.

Ke keu

Nā hōʻailona: hoʻonui i ka nui o nā hopena hopena. ʻO ka mea maʻamau ka nui o ke koko kiʻekiʻe, ka puʻuwai naʻau, migraine a me ka dizziness. Hiki ke hana i kēia mai kekahi overdose hiki ʻole ke lawelawe, a mai kahi kūikawā.

ʻO ka maʻi overdose: kāhea i ke kauka, nāna hoʻi e kuhikuhi i kahi hana hōʻeha a hiki i ka hoʻokō ʻana.

Ke noi

Hoʻoikaika nā papa papa inoa Sibutramine no ka hoʻohana ʻana. ʻAʻole pono ka make o ka lāʻau mua ma mua o 10 mg no ka lā. Inā loaʻa i ka lāʻau lapaʻau nā pulupulu, a laila pono ke lawe ʻia i nā kapia i ke kakahiaka me ka nui o ka wai. Inā hala ʻia kahi papa hoʻokahi, a laila e pāpālua i ka hopena ma hope. Inā ʻaʻohe mea like i ka wai e hiki ai i ka malama hoʻokahi, a laila hiki iā ʻoe ke hoʻonui i ke ʻano i ka 15 mg i kēlā me kēia lā, akāʻaʻohe. Akā wale nō me ka hoʻomehana kūpono o ka lāʻau lapaʻau.

ʻO ka lōʻihi o ke lawe ʻana i ka sibutramine, ʻokoʻa nā manaʻo i ʻaneʻi. Akā, ʻaʻole ʻoe e lawe iā ia no kahi o hoʻokahi makahiki. ʻOiai, ʻaʻohe hilinaʻi i ka palekana a me ka pono o ka lāʻau lapaʻau no ka manawa lōʻihi. Inā ʻaʻohe kaulea maikaʻi i ka emi ʻana o ke kino o ke kino ma ka liʻiliʻi o 5% o ka nui o ka paona i nā mahina ʻekolu o ka hoʻohana mua ʻana, a laila pono ʻoe e hoopo i ka lawe ʻana i ka lāʻau.

ʻO nā mea mālama palekana

Pono e hoʻomaopopo ʻia e lawe mai i ka lāʻau lapaʻau ka hopena maikaʻi i ke hui pū me ka meaʻai. Ke lawe nei i kēia huahana, pono ʻoe e hahai i nā lula, e ka nānā ʻana i hiki iā ʻoe ke pale i nā hopena maikaʻi ʻole.

Eia nā mea nui:

• Ke kaʻa ʻana me ke kaʻa
• ʻO ka hoʻohana like ʻana o ka sibutramine a me nā mea hoʻohana anorexigenic,
• Mai lawe i ka waiʻona me ka sibutramine,
• ʻAe ma hope o 65 mau makahiki.

ʻAʻole ia e kauoha ʻia e lawe i ka sibutramine i ka wā hāpai a me ka lactation, no ka mea ʻaʻole i lawe ʻia nā haʻawina. ʻAʻole kaulana ʻia paha ka mea i loaʻa i ka lāʻau a me nā mea metabolic i loko o ka waiū umauma.

ʻO Sibutramine kahi hana lapaʻau e loaʻa ai nā mea hou a me nā maʻi. Ke hoʻoholo nei i ka hoʻolilo ʻana i ke kaupaona ʻana me nā paila e pili ana i ka sibutramine, e noʻonoʻo pono e kamaʻilio mua me ke kauka, heluhelu i nā ʻōlelo i pili no ka hoʻohana ʻana a mālama i nā loiloi o ka poʻe e lawe ana i kēia mau kālā. Hoʻomaka maikaʻi aʻe me nā mea ʻai, me nā haʻuki. I nā hihia koʻikoʻi, aia kekahi mau meaʻaiʻai e hoʻopalulu ai i ka momona, akā ʻoi aku ka pōʻino.

ʻO kou manaʻo i ka ʻatikala:

Ka lāʻau Kahalawai i hoʻohana ʻia ma ke ʻano he kōkua ʻana i ka hakakā me ka pohō. Hoʻohana ʻia ka lāʻau lapaʻau i ka hui pū me kahi meaʻai mālama kūpono a hoʻonui i nā hana kino. Kahalawai hōʻike wale ʻia i nā mea maʻi me kahi kikoʻī (a ke koʻikoʻi o ka pehu o ke kino (BMI) o nā liʻiliʻi he 30 a me nā mea maʻi me ka BMI o ka oi aku ma mua o 27 a me nā mea e ola ai e like me ka maʻi diabetes a i ke koko kiʻekiʻe.

Sibutramine: data ikehu

Me ka hoʻomalahala o ka sibutramine i ʻAmelika a me ʻEulopa, ke ulu nui nei nā hōʻike e pili ana i ka lawe ʻana i nā paila i kau ʻia ma ia alakaʻi i ka piʻi nui ʻana o nā hihia hoʻomakeke, hoʻopiʻi ka naʻau a me nā hōʻeha, nā mea nui o kāna mau mea hoʻohana "noho iho" ma sibutramine.

Ua hana aku kēia i nā mea hana e noiʻi piha i ka sibutramine a pāpā i kona kūʻai ʻana, e hoʻopili ana i ka sibutramine i ka hui o nā psychotropics potent e like me nā lāʻau lapaʻau maʻamau.

Ma ke kānāwai Lūkia, ua hāʻawi ʻia ka sibutramine a me nā mea i hoʻopaʻa ʻia i ka pūʻulu o nā lāʻau lapaʻau a pāpā ʻia ʻo ia e kūʻai aku ʻole iā lākou me ka loaʻa ʻole o ke kauka lāʻau lapaʻau kūikawā.ʻO nā mea ʻē aʻe nā hihia o kahi kiʻekiʻe o ka momona a me ka hikiʻole ke hoʻohana i nā ala ʻē aʻe, ʻoi aku ka maikaʻi o ka hōʻemi ʻana i ka hopena o ke kino.

Na wai nā sibutramine

Ma ka nui o nā annotations o nā lāʻau lapaʻau e loaʻa ana i ka sibutramine, ʻaʻohe hōʻailona e hōʻike ʻia (a ʻano iki ka palaka a ʻole i piha) o nā hopena ʻaoʻao a me nā contraindications. Hūnā nā mea hana iā lākou, no ka mea e pili pono kēia i nā kūʻai ʻana o nā lāʻau i loaʻa sibutramine.

Eia nō naʻe, he ākea ka papa inoa o nā contraindications. E pili ana kēia:

• maʻi a me nā maʻi maʻi (hypertension, maʻi ʻeha coronary, puʻuwai naʻau),
• kaʻeha cerebrovascular,
• maʻi o ka noʻonoʻo a me ka neurological me ka bulimia a i ʻole anorexia,
• maʻi ʻaʻai a ʻōpio paha
• nā maʻi hōʻiliʻili
• maʻi maka (glaucoma, myopia),
• ʻōpū o ka epilepsy, hoʻomālamalama.

Eia kekahi, ua pāpā ʻia ka sibutramine e hoʻohana pū me ka hui ʻana me nā mea ʻai he nui - nā lāʻau lapaʻau no ka mālama ʻana i ka ʻōnaehana nīnao, nā antibiotika, nā lāʻau lapaʻau e hoʻopilikia ai i ka coagulation koko.

ʻAʻole kūpono ka lāʻau lapaʻau i ka waiʻona, pāpā paʻa loa ia i ka wā o ka hapai a me ka lactation, ma lalo o nā makahiki he 18 a ma hope o 60 mau makahiki. A ʻaʻole i pau nā palena a me nā pāpā ʻana.

ʻO Sibutramine: nā hopena maikaʻiʻole

Ma hope o ka lawe ʻana i ka sibutramine, nui nā hopena maikaʻiʻole. ʻO ka mea mua, ʻo ka lawe ʻana i nā lāʻau lapaʻau e pili ana i kēia waiwai e hāʻawi i kahi ʻano like me ka hilinaʻi. Ke hoʻopau ʻoe i ka mea, hele mai:

• e holomua ana ka ʻōpū e like me ka neʻe ʻana,
• huhū, hoʻāla
• ʻeha, poʻomana,
• ka hoʻoweliweli ʻana, nawaliwali.

Ma nā hihia koʻikoʻi, pilikia ka ihu a ka luaʻi, ka ʻōpū, ka ʻeha o ka puʻuwai, ka ʻike hōʻeha, ka ʻeha o hope, paʻakikī ka hanu, ka ʻeha, ka kūwili ʻana o ka huina, ka anorexia, ka hana hewa, ka huakaʻi, nā pilikia o ka ʻili.

A ʻaʻole ʻo kēia nā hopena maikaʻi ʻole a pau o ka lawe sibutramine. ʻAʻole mea nui ka mea nui i ka wā o nā hoʻokolohua ma luna o nā holoholona, ​​ua ʻike ʻia kahi hopena teratative o ka sibutramine, i mea e hoʻohālikelike ai i ka maʻi fetal.

He paʻakikī loa ke kaʻina o ka pohō ke kaumaha a hiki i kekahi ke kōkua me ka maikaʻi. Hoʻopau kēia i nā lāʻau lapaʻau. Pono ka waiwai o Sibutramine a me nā mea hoʻohālike i waena o ka poʻe e nalowale i ka paona. Ua kūʻai mua ʻia kēia huahana ma ka ʻāina o ka Lūkini Lūkini a kūʻai ʻia aku e ka preseta, e like me ka hōʻike ʻia e nā kuhikuhi no ka hoʻohana ʻana iā Sibutramine. Akā i kēia manawa, i loko o nā hale kūʻai, ʻaʻole i ʻike ka lāʻau me kēia inoa. Aia wale nō kāna mau analogues i loaʻa i ka sibutramine ma ke ʻano ikaika.

ʻO ia i hana me he antidepressant kahi i hoʻomohala ʻia ke ʻano o ka paʻakai sibutramine hydrochloride. Lawe ʻia kāna hana synthes e nā ʻepekema ʻAmelika. I ka wā o nā hoʻokolohua o ka lāʻau lapaʻau, ua ʻike ʻia he lawe ʻole ia no ke kumu i manaʻo ai - he nui loa nā hopena a me nā pilikia i ka hoʻohui pū ʻana me nā lāʻau lapaʻau. Ma ke kaʻina noiʻi, ʻike ʻia kahi hopena anorexigenic no sibutramine - ka hiki ke hoʻokaʻawale i ka makemake ma ke pae o ka ʻōnaehana ma waena o ka pūnaehana, a ma hope o ka lāʻau i manaʻo ʻia he ala no ka nalowale kaupaona.

Ka haki o ka Dietetics

I kēia manawa, ʻo ka sibutramine i nā lāʻau lapaʻau ke kiʻi ʻia i ka 10 a me 15 mg. I ka wā o ka hoʻāʻo ʻana i ka lāʻau lapaʻau, ua hoʻohana ʻia nā dosage ua ʻoi aku ke kiʻekiʻe o ka nui o nā kaila o kēia manawa. ʻO ka hopena - maʻalahi ka wikiwiki. Ua aneane pau loa ka makemake o ka mea maʻi, a ua hoʻolōʻihi ʻia nā ʻai momona i ʻelua mau manawa ma ke ʻano he ikaika, no ka mea, ʻo ka pono o ke olakino e hōʻoluʻolu mau ai.

Ua hoʻohuli ʻo Sibutramine i ka maikaʻi no ke kaumaha nui o ka pathological, i ka manawa i hele ai ka nui o ke kino kikoʻī o ke kino ma kahi o ka nui o ka 30. Hiki ke kapa ʻia nā noiʻi he ʻano maoli i loko o ka pāʻai, inā ʻaʻole no ka hopena o ka lāʻau.Ua hele pū ʻia ka hoʻohana nui ʻana me ka nui o nā hopena he nui, ʻo ia hoʻi.

• puʻuwai a me nā hahau,
• nā nāʻeʻeha o ka naʻau
• gastrointestinal mukosa lesi,
• nā maʻi hōʻeha
• nā manaʻo noʻonoʻo.

No laila, i kēlā kahua i hiki ʻole iā lākou ke hoʻolaha i ka lāʻau lapaʻau i ka hoʻohana nui ʻana. Loaʻa i nā dole therapeutic liʻiliʻi loa, loaʻa nā ʻepekema i ka dinamics maikaʻi i ka hoʻohaʻahaʻa ʻana i ka hopena o nā hopena ʻaoʻao, kahi hiki ke hoʻopaʻa inoa i ka lāʻau lapaʻau e like me ka lāʻau no ka mālamaʻana i ka momona.

Ua hoʻomaka ka nui o nā ʻoihana lapaʻau e hana i ke ʻano a me nā kūmole. Akā, ʻaʻole ia he hanana holomua nui loa, e like me nā leka e pili ana i nā hopena hou ʻole i makemake ʻia. I ka hopena, ʻo ka makahiki 2010, ua hoʻokomo ʻo ʻAmelika a me ʻEulopa i ka sibutramine i ka papa inoa o nā lāʻau lapaʻau i pāpā ʻia. ʻO kekahi mau'āina, no ka laʻana ʻo Russia, ua komo iā ia i loko o ka papa inoa o nā lāʻau lapaʻau i hiki ke nui i ka hopena o ka lāʻau lapaʻau ponoʻī iā lākou.

Ka mīkini hōʻemi

ʻO "Sibutramine" a i kāna mea e hoʻopili ai e kuhikuhi ana e nā mea hoʻomaʻamaʻa a i ʻole psychiatrists i nā poʻe me ka maʻi hānai a me nā pilikia ʻai. Hoʻoh ʻo pinepine i ka manawa inā pono nā ʻano ʻē aʻe e hōʻemi ai i ka paona. Ke hana nei ʻo Sibutramine ma ke kino e like me kēia:

• ālai ka hoʻopaʻa ʻia ʻana o ka serotonin neurotransmitter,
• ālai ka hoʻopaʻa ʻana o ka neurotransmitter norepinephrine,
• i kahi mea liʻiliʻi loa e pale aku i ka piʻi ʻana o dopamine.

ʻO ka hanaʻinoʻole a me ka hoʻololi ʻana o nā mea hoʻopihapiha ma ke kikowaena olakino ma mua e alakaʻi i ke kūkulu ʻana i nā hana like i loko o nā kino āpau a me nā kiko. ʻO nā hopena o ka lawe ʻana i ka sibutramine:

• ka momona - ke ʻano nui o ka pololi o ka mea maʻi, ʻaʻole paha ʻo ia e ʻike hou ʻole ai, ʻoiai inā ʻaʻole lā mea ʻai i ka lā hoʻokahi,
• metabolism - ma muli o ka hopena i ke vascular tone, hoʻonui ʻia i ka wela, hoʻoneʻe ke kino i ka nui aku i ka ikehu, e hoʻohana ana i kona mau nā kānaka mai ka depot,
• ʻā ʻana o ka momona - e pili ana i ka hopena ma mua, ʻo ka hoʻemi ʻia ʻana o ka ikehu o waho
• satiation - ma muli o ka hune o ka makemake, ʻoluʻolu piha o ka mea maʻi i ka manawa koke o ka hoʻomaka ʻana o ka ʻina
• kūwili ka uku - hoʻomaikaʻi nui ma muli o ka hoʻonui ʻana o ka hoʻokaʻina serotonin i nā membous mucous o ka gastrointestinal tract (GIT), peristalsis a me ka hoʻoulu wai i ka hoʻomaikaʻi,
• ka maikaʻi - hoʻomaikaʻi ma muli o ka hoʻonui ʻana i ka pae o "ka holi o ka hauʻoli", ʻoliʻoli ka mea maʻi inā ʻoiai ke pili ʻana o ka meaʻai,
• ka hana - e hoʻonui ana ma muli o ka hoʻonui ʻia o ka hoʻoulu ʻana o ka pūnaehana sentral, ʻike nui ka mea maʻi i ka neʻe ʻana o ka ikaika, ikaika, mākaukau no ka hana ma ke ao.

ʻO kekahi o nā hoʻololi i ka hana o ka lolo i hoʻonāukiuki ʻia e ka hoʻohana ʻana o sibutramine i hōʻemi i ka hoʻolilo ʻana i nā paona i nā pae āpau: ke kino, naʻauʻai, hormonal. ʻO kahi hiʻohiʻona o ka lāʻau lapaʻau ka hiki ke hoʻoikaika i ka puhi ʻana i nā momona "brown". ʻOiai aia kēia mau hōʻuluʻulu i loko o nā liʻiliʻi liʻiliʻi i ke kino o ke kanaka, hana lākou i ka hana koʻikoʻi i ke kaʻina o ka thermoregulation. A ke hoʻokaʻawale nei kā lākou hōʻili ʻana i ka hoʻopau ʻana i ka "momona keʻokeʻo", kahi keu o ia mea i hui pū ʻia.

He mea maʻamau nō hoʻi nā sibutramine e hoʻoponopono i ke kaulike o ka momona ma ke kino. I ka kikoʻī, hoʻōla i ka lāʻau lapaʻau i ka hana a me nā mea huna o ka hua bile. No kēia kumu, nā hōʻailona no ka hoʻohana ʻana i ka lāʻau lapaʻau e pili ana i ka momona i ka type 2 diabetes mellitus a me nā maʻi lipid metabolism. ʻO ke kūlana no ke koho ʻana i ka sibutramine i kēia mau hihia, ʻo ia ka nui o ka nui o ka pehu o ke kino o ke kino o 27.

Nā ʻōkuhi no ka hoʻohana sibutramine

Aia ʻo Sibutramine i ka hui o nā lāʻau mālama momona i manaʻo ʻia "ma kahi hope loa". ʻO ka loaʻa ʻana o nā kālā e pono ke ʻae me ka kauka e hōʻoia i nā hana a pau e hoʻoponopono ai i ke kaumaha o ke kino. Pono ke kūpono o kēia ala no ka hopena nui o ke olakino e hoʻopuni nei me ka hoʻowalewale i ka hana o ka ʻōnaehana piʻina.

Hoʻomaka pinepine, hoʻomaka kahi hoʻokomo i ka hapa liʻiliʻi o 10 mg. Lawe ʻia kahi papa o ka dosage kūpono no ke kuʻi ʻana me ka nui o ka wai. ʻO ka lawe ʻana i ka lāʻau lapaʻau ʻaʻole ia e hilinaʻi ʻia i ka manawa o ka pāʻina, akā ua ʻōlelo ke kauka i ka inu ʻana i nā papa i ke kakahiaka ma kahi ʻōpū ʻole ma hope o ke ala ʻana e hōʻoia i nā manaʻo o ka nui o ka lāʻau i ke koko ma ke kakahiaka.

E hoʻomohala ʻia ka hana e like me kēia:

• 80% o nā ʻike o ka papa i kau ʻia ma ka ʻōpū liʻiliʻi,
• nā kahe neʻe o ka sibutramine neʻe - hoʻokuʻu ʻia i loko o ke koko a hoʻopaʻa i kona mau protein,
• piʻi ka nui o ke koko i kahi kiʻekiʻe - ʻekolu a ʻehā mau hola ma hope o ka nānā ʻana,
• nā kaisa o ka lāʻau lapaʻau - ua hoʻokaʻawale ʻia ma ke kino holoʻokoʻa, e hōʻiliʻili ana i nā hui synaptic,
• ma hope o ka lawe ʻana i ka papa ʻehā, ua paʻa ka hoʻokō paʻa o ka lāʻau i loko o nā ʻāpana.

ʻAʻole pono ke hoʻokipa me ka meaʻai. ʻO ka ʻoiaʻiʻo o ka hoʻopili ʻana o ka lāʻau mai ka palaka ʻana i nā meaʻai, ua hoʻēmi ia e kahi hapakolu. Hoʻopau ʻia ka waiwai mai ke kino e nā keiki. Loaʻa nā hapa o nā metabolites i loko o nā lau no kahi mahina hoʻokahi mahina, akā ko lākou nānā ma hope o ka pau ʻana o ka hoʻokō e lawe ʻole i ka hopena therapeutic.

Hiki ke lawe ʻia nā lāʻau ʻai Sibutramin i hoʻokahi makahiki. I kēia manawa ua inu lākou i nā analogues. Inā lawa ka waiʻala liʻiliʻi maʻa loa o 10 mg, koe e mau ana a hiki i ka hopena o ka mālama ʻana. Ke koi nei ka hoʻonui ʻana i ka dosage inā i loko o ʻelua a ʻekolu mau mahina ma hope o ka hoʻomaka ʻana o ka hana, ʻo ka "ʻāpala" o ka mea maʻi e 3% o ka nui o ke kaumaha o ke kino. A laila pili ka sibutramine i loko o kahi waihona o 15 mg. I ka mea e hōʻemi iki ka laina plumb, ua kāpae ʻia ka lāʻau lapaʻau ma muli o ka hoʻopiʻi ʻole. ʻO nā hoʻoholo āpau e pili ana i ka dosage, a me ka manawa o ka mālama ʻana, hana ʻia e ke kauka.

Nā Kuhi Harm

Loaʻa i ke kōkua piha o ka lāʻau lapaʻau i ke kaʻina o ka hōʻemi ʻana o ka paona, ua kū mai ka nīnau: "He aha kaʻu e uku aku ai i ke kākoʻo maoli i ke ala e kū like ai?" Loaʻa ka pane i loko o nā hualoaʻa o nā noi ʻana o ka waiwai, e kākau inoa i nā hopena ʻona. Akā ke nānā nei i nā loiloi o ka lawe ʻana i ke kaupaona ʻana, hiki iā mākou ke ʻōlelo i hiki ke hoʻomanawanui pinepine ʻia ka lāʻau lapaʻau. ʻO kekahi mau hopena leʻaleʻa e loaʻa ana i ka hoʻomaka ʻana o ka hopena e nalowale ana i ka ikaika a i ʻole nā ​​nalo inā ka lawe pololei ʻana ʻo sibutramine. ʻO nā hopena ʻokoʻa maʻamau:

• ka malo maloʻo
• ka kue ana i ka papaa
• hoʻoholomua
• poʻomanaʻo
• puʻuwai puʻuwai
• ʻōpala
• nele i ka momona,
• ka hoʻonui iki ʻana i ke koko.

ʻO ka hopena o ka sibutramine, e like me nā lāʻau lapaʻau ʻē aʻe, e loaʻa paha ka hopena o ka hopena alaka, i hōʻike ʻia e urticaria a me pruritus. I kēia hihia, ua kāpae ʻia ka lāʻau lapaʻau.

ʻO nā hopena ʻino hou loa o ka lāʻau lapaʻau ka mea e hoʻohui a hoʻihoʻi hoʻi. ʻAʻole paʻa ka hilinaʻi o nā lāʻau lapaʻau, akā ʻo ka manawa mua ma hope o ka hoʻokuʻu ʻana o ka mālama ʻana, e piʻi nui paha ka kūlana noʻonoʻo o ka mea maʻi, ka mea e hoʻonāukiuki i ka hoʻi ʻana mai i ka hana ʻai kahiko. No ka hōʻemi ʻana i ka ikaika o kēia mau hopena, kaukaʻi nā kauka i ka hoʻōki ʻana i ka mālama ʻana, a hōʻemi iki ʻia ka nui o ka lāʻau.

Hoʻokomo ʻia nā hopena i makemake ʻole ʻia:

• nā maʻi noʻonoʻo (a me ke ʻano suicidal),
• ʻai ʻaola (bulimia, anorexia),
• hooulu o ka hopohopo o ka naau,
• ʻōpala
• hoʻonui koʻikoʻi i ke koko,
• tachycardia
• mai nāwaliwali
• ka neʻe o ka pōkole peripheral.

Kuhi i ka mea hiki ke kūʻai ʻia ma mua me ka loaʻa ʻole o ka sibutramine, ʻaʻole paha i hoʻopaʻa inoa ʻia kekahi mau ʻaoʻao e ka mea hana a ʻike ʻole ʻia i nā ʻōlelo kuhikuhi. Kaukaʻi nā kauka i ka nānā i nā mea e nalowale nei i ke kaupaona ʻana no ka pono o ka lāʻau lapaʻau loea. Ma kēia ala wale nō ke emi nui nei ka hopena o nā hopena ʻokoʻa.

Kauʻikahi (Orlistat, Orlistatum)

• Loaʻa kahi hopena peripheral
• Hoʻolima ka ʻano hana o ka hana ma ka ʻano o ka triglycerides i ka wā o nā molekika o ka gastricatic a me ka pancreatic lipase paʻa, ʻaʻole ʻae iā lākou e launa me nā lipids. I nā huaʻōlelo aʻe, ʻaʻole hiki i nā enzyme gastric ma lalo o ka mana o ka orlistat ʻaʻole hiki ke "hoʻopili" i nā momona, kahi e pau nei i ke kino kūlohelohe (ʻo ia me nā feces) ma loko o ke kaʻina hana o ka kūwili kūwaho (gastrointestinal tract).
• ʻAʻole maikaʻi ka waiwai mai ka gastrointestinal tract, i.e. ʻaʻole e komo i ke kino (ka nui o ka excreted ma hope o 3 - 5 mau lā, a ma kahi o 2% e hoʻopili ʻia ma o nā keiki)
• Nā LDL Haʻahaʻo (nā Lopopopo Wawa liʻiliʻi Hoʻopau)
• Hoʻonuiʻia HDL (High Density)
• Hoemi i ke koko (ke koko)
• Hoʻopau i ka wikiwiki
• Hoʻohana ʻia lākou i ka mālama ʻana, a ma muli me kēia ʻano waiwai uku o ka hiki ʻana i nā mea hoʻoliʻoliwa
• Ke kuhikuhi nei Dosis: 1 mau kapihi (120 mg) 3 mau lā i kēlā me kēia papa

• Hoʻopili, ʻaihue lau
• Rectal aila pi
• Ka huhū ʻo Fecal
• Hoʻēmi i ka lawe ʻana o nā momona-soluble o ka momona (i hōʻike ʻia kahi intivitamin intake)

Sibutramine (Sibutramine, sibutramine hydrochloride monohydrate)

• Loaʻa ia i ka hopena waena
• He anorexigenic e hoʻemi ana i ka makemake (ma hope o ka mea e hoʻomaka ai ke kanaka e hoʻopau i ka meaʻai liʻiliʻi)
• Hoʻonui i ka manaʻo piha
• Hoʻonui i nā thermogenesis (hoʻonui i ke ʻano o ke kino)
• Hoʻonui nā HDL
• Hoʻemi i ka LDL, triglycerides, hōʻemi kolamu, ka uric acid
• Hoʻonui i ke koko a hoʻonui i ka puʻuwai, i kekahi manawa i kahi nui ("wahaheʻe" ʻike ʻia)
• Hoʻopili ʻia i loko o ke kino e 77%
• ʻO kona hopena kiʻekiʻe e loaʻa 1,2 mau hola ma hope o ka lawe ʻana i ka lāʻau lapaʻau
• Hoʻohana ʻia i ka mālamaʻana i ka momona me kahi BMI o 30 kg / m 2 a i ʻole a i ʻole me ka BMI o 27 kg / m 2
• E pili paha i ka hana platelet

• Insomnia
• Nā Aliʻi
• ʻʻAla
• Ponoʻeha
• Ka hopohopo
• Paresthesia (ʻike ka ʻike ʻole o nā ʻano ʻāpana o ke kino)
• Hoʻololi ka hopena
• ʻO ka psychosis a me ke kahakaha i nā hihia kaʻawale
• Tachycardia
• Palpitations puʻuwai
• Hoʻonui i ke koko
• Hoʻokomoʻi (ʻoi i ka hyperemia me ka ʻike ʻana o ka mahana)
• ʻO ka maʻi Shenlein-Genoch a me thrombocytopenia i nā hihia kaʻawale
• Putu maloʻo
• Kau ka momona
• Kaaudeana
• Nā maʻi maʻi
• Kahula
• Hoʻonui o nā hemorrhoids

I nā huaʻōlelo ʻē aʻe, ʻoi aku kēia mau mea e pili i nā kikowaena kūloko a me nā ʻōnaehana cardiovascular. No laila, ʻaʻole hiki ke hoʻohana pū i ka hui pū me nā lāʻau ʻē aʻe e hana ana i ka ʻōnaehana kelepona (antidepressants, antipsychotics, tryptophanes). Hoʻonui ia i ka kau ma luna o nā pepi a me nā pōpoki, ʻoiai e hoʻohuihui ʻia a komo i loko o ke kino ma o ka huina.

ʻOiai, ʻae ʻia kona hoʻohana wā lōʻihi no ka 1 makahiki!

Lapaʻau

Ke hana lāʻau lapaʻau - anorexigenic.

Mālama i ka reuptake o nā neurotransmitters - serotonin a me norepinephrine mai ka ʻāpana synaptic, hoʻokaʻawale i nā pili o ka synergistic o ka waena o ka norepinephrine a me nā ʻōnaehana serotonergic. Hoʻemi i ka momona a me ka nui o nā meaʻai i hoʻopau (hoʻonui i ka manaʻo o ka piha), hoʻonui i ka thermogenesis (ma muli o ka hana kūlohelohe o nā beta3-adrenergic receptors), he hopena i ka lipine adipose brown. Kūkulu ʻia ia mau metabolites ikaika i loko o ke kino (ma mua a me nā ʻōmua piha), keu loa i ka sibutramine ma kona hiki ke pale aku i ka reuptake o serotonin a me norepinephrine. I loko o nā haʻawina vitro, hoʻohālikelike ka metabolites ikaika i ka hoʻihoʻi hou ʻana i ka dopamine, akā 3 mau manawa nāwaliwali ma mua o 5-HT a me norepinephrine. ʻAʻole ʻo ka sibutramine a me nā mea hoʻonaninani keu e pili ana i ka hoʻokuʻu ʻana o nā monoamines a me nā hana MAO, ʻaʻole i launa pū me nā loiloi neurotransmitter, e pili ana i ka serotonergic, adrenergic, dopaminergic, benzodiazepine a me ka glutamate (NMDA), a ʻaʻohe hopena anticholinergic a me antihistamine. Ke hōʻike nei i ka uptake 5-HT platelet a hoʻololi i ka hana platelet.

ʻO ka emi ʻana o ke kaumaha o ke kino me ka piʻi ʻana o ka ʻike o HDL i ka serum a me ka hoʻohaʻahaʻa ʻana me ka nui o ka triglycerides, ka nui o ka kolamu, LDL a me ka uric acid.

I ka wā o ka mālama ʻana, he liʻiliʻi iki i ke kahe o ke koko ma ka hoʻomaha (e 1-3 mmHg) a me ka hoʻonui ʻana o ka maʻi pākahi o nā manawa (e 3-7 beats / min), akā i nā hanana kaawale i hiki ke hoʻololi ʻia nā loli. Me ka hoʻohana like me ka microsomal oxidation inhibitors, hoʻonui ʻia ka puʻuwai (ma ka 2.5 bpm) a me ka palena o ka QT (hoʻonui ʻia e 9.5 ms).

I nā makahiki 2 o nā kaila a me nā mau wai ka wā e hoʻohana ai i nā doses, ma muli o kahi i ʻike ai i ka nui o ka wahi i ʻike ʻia ma lalo o nā ʻūlū ʻana o ka manawa (AUCs) no ʻelua mau metabolites ikaika ʻo 0.5-21 mau manawa i ʻoi aku ma mua o ka MRI, ua hoʻonui i ka ulu o nā ʻōpū o benign. testicular interstitial tissue e hele nui i ka nui kāne kāne. ʻAʻole i ʻike ʻia ka hopena carcinogenic i nā kiʻino a me nā mauʻu wahine. ʻAʻohe o kahi hopena mutagenic, ʻaʻole pili i ka ulu. I ka hāʻawi ʻia ʻana o nā lālani, AUCs o nā metidite ikaika no 43 mau manawa i ʻoi aku ma mua o nā mea i ʻike ʻia me MRI, ʻaʻohe ʻike maka teratogenic. Eia nō naʻe, ma nā haʻawina i hana ʻia ma nā Keleti Belted Keleti ma lalo o nā kūlana i loaʻa aku ai nā AUCs o nā metabolites ikaika o sibutramine he 5 mau manawa nui ma mua o ka hoʻohana ʻana i MRI, ua ʻike ʻia nā anomalies o ka hoʻomohala kino i nā keiki (nā loli i ke ʻano a i ʻole ka nui o ka muzzle, auricle, tail, a me ka mānoanoa o ka iwi. )

Ma hope o ka lawelawe waha, ua hoʻoiho koke ʻia mai ka hana a ka digestive ma kahi o 77%. I ka "hele mua" ma o ka puʻu, ka mea e hoʻomōhala ia i ka biotransformation ma lalo o ka mana o CYP3A4 isoenzyme o ka cytochrome P450 me ka hoʻokumu ʻana o nā metabolites mākeke (mono- a me didemethylsibutramine). Ma hope o ka lawe ʻana i ka pā hoʻokahi o 15 mg o Cmax, monodesmethylsibutramine he 4 ng / ml (3.2–4.8 ng / ml), a ʻo ka didesmethylsibutramine he 6.4 ng / ml (5.6-77 ng / ml). Loaʻa ka Cmax ma hope o 1,2 mau hola (sibutramine), 3-4 mau hola (nā metabolites ikaika). ʻO kahi pāʻina like me ka hoʻohaʻahaʻa i ka Cmax o nā metabolites ma 30% a hoʻonui i ka manawa e hōʻea iā ia i ka 3 hola me ka ʻole o ka hoʻololi ʻana iā AUC. Hāʻawi koke ʻia ia ma nā lole. ʻO ka mana o ka protein e 97% (sibutramine) a me 94% (mono- a me didesmethylsibutramine). Loaʻa ka pālākiō kūlike o nā metabolites ikaika i ke koko i loko o 4 mau lā ma hope o ka hoʻomaka ʻana o ka hoʻomaʻamaʻa a ua like me 2 mau manawa nui aʻe ma mua o ka pae o ka plasma ma hope o ka lawe ʻana i hoʻokahi pāʻai. T1 / 2 o nā sibutramine - 1,1 mau hola, monodemethylsibutramine - 14 mau hola, didesmethylsibutramine - mau hola 16. Nā metala metabolite e hana ana i ka hydroxylation a me ka konohiki me ka hoʻokumu ʻana o nā metabolite hana ʻole, ka mea i hoʻopiʻi ʻia e nā ʻōpū.

He aha ka sibutramine?

ʻO ka Sibutramine kahi lāʻau lapaʻau. I ka mua, ua hoʻomohala ʻia a hoʻokolohua ʻia me he antidepressant, akā ua ʻike nā kānaka ʻepekema he mana ikaika anorexigenic, ʻo ia hoʻi, hiki iā ia ke hōʻemi i ka momona.

Mai ka makahiki 1997, ua hoʻohana ʻia ma ka United States a me nā aupuni ʻē aʻe i ala ala e hoʻemi ai i ke kaupaona, e kuhikuhi ana i nā poʻe me nā ʻano maʻi like ʻole. ʻAʻole lōʻihi nā hopena ʻaoʻao i ka wā e hiki mai ana.

Ua hoʻohuli hou ʻia ka sibutramine a me ke kaumaha, kahi hiki ke hoʻohālikelike ʻia me kahi lāʻau lapaʻau. Eia kekahi, hoʻonui ʻo ia i ka pilikia o ka maʻi cardiovascular, nui ka poʻe i hōʻeha i ka hōʻeha a me ka puʻuwai puʻuwai ma ke lawe ʻana. ʻAʻohe mea hōʻoia ʻole i ka hoʻohana ʻana o ka sibutramine i mea i make ai ka poʻe maʻi.

Ke papa ʻia i ʻole nā ​​kālā

ʻO nā lāʻau lapaʻau kahi Sibutramine kahi papa inoa maikaʻi loa o nā contraindications koʻikoʻi. ʻO nā mea nui nui ka mau hewaʻole ma ka hana o ka puʻuwai, nā ʻōpū a me nā ʻōpū, ʻo ka mea hana ka waiwai nui i kēia mau kino.

ʻOi aku ka ulu ʻana o ka lāʻau lapaʻau inā ʻike nui inā ʻaʻole o ke ahonui ke laʻa, akā ʻo ka lua. ʻO ka hapanui pinepine, nā maʻi metabolic a me ka hana a nā kino kino i ke alakaʻi.Hoʻomaopopo ka hana lapaʻau i ka pono o ka sibutramine i kēlā mau kūlana. ʻO nā contraindications ʻē aʻe no ka lawe ʻana i ka lāʻau.

• malalo o 18 makahiki
• ma hope o 65 mau makahiki
• me ka bulimia,
• me ka anorexia,
• nā manaʻo noʻonoʻo
• pālahalaha
• haehae maʻi
• prostate adenoma
• glaucoma
• hana hōʻino mea
• hilinaʻi i ka lāʻau
• waiʻona.

Pono ka mālama nui ʻana i ka koho ʻana o ka sibutramine i ka epileptics a me ka poʻe i loaʻa i ka lehelehe, me ka poʻe i loaʻa hematopoiesis pōkole a i ʻole ke kipi koko.

Hāʻawi ʻia i ka nui o ka loaʻa o ka maʻi nui a me nā hoʻopiʻi, pono e haʻalele ʻia i ka wai i ka wā o ka mālama ʻana. I mea e wehe ai i ke kino kahi lāʻau lapaʻau i nānā nui ʻole a i ʻole hōʻino ʻia, pono ke lawe ʻia ka nui o ka gastric, e lawe ʻia he adsorbent a laila e kāhea ʻia kahi ambulance.

ʻO wai nā lāʻau lapaʻau momona kiʻekiʻe.

Ua hiki mai ka manawa e lawe i nā hopena liʻiliʻi a koho i nā liʻiliʻi liʻiliʻi ʻelua (inā paha hiki ke hana ʻia kēia mea).

ʻAʻole mākou e minamina i ka hoʻomanaʻo ʻana i ka poʻe heluhelu e ʻoi aku ka maikaʻi o ka hāʻawi ʻana i nā mea kūlohelohe maoli ʻole me ka ʻole o ka hoʻohana ʻana i nā lāʻau lapaʻau a lawelawe i kā lākou kōkua wale i ka manawa koʻikoʻi inā hiki ʻole ke hoʻōla hou ʻia me ka ʻole o lākou. ʻOi aku ka maikaʻi o ka hoʻopiʻi ʻana i nā mea i kūkulu ʻia i loko o nā wā Soviet a i kēia manawa, ʻaʻole i hana nā mea mālama ola hou i nā loli nui i ka ʻōnaehana o ka pono olakino.

Akā no ka mea ua kauoha mai ke kauka iā ia, a laila e noʻonoʻo e ʻike i nā mea hana ʻelua e ʻona nui loa?

Hoʻomaopopo a ʻaʻohe kumu hoʻokolohua kūpono no ka hōʻoia ʻana i ka lāʻau a hiki i kēia lā. Hoʻokumu ʻia nā ʻikepili e pili ana i ka palekana o ko lākou mau pili aloha i nā holoholona i lawe ʻia ma luna o nā holoholona, ​​a ʻo kēia ke hana i ka hopena o ka hopena. Akā e haʻi aku iā ʻoe i kahi mea huna, ʻo ka hapa nui o nā lāʻau lapaʻau i kūʻai ʻia i loko o nā lāʻau lapaʻau o ka Lūkini Russian kūleʻa ʻaʻole i loiloi maikaʻi ʻia (ʻo ka hapa nui ʻaʻole hiki ke kapa ʻia he "lāʻau lapaʻau", no ka mea ke kālele ʻia nei lākou ʻaʻole e pili ana i ka mālama ʻana, akā ma ka hoʻoili ʻana i nā hōʻailona nui o ka maʻi). ʻO ka mea nui i nā lāʻau o kēia wā he "hana" lākou, a pehea hoʻi he kekekona a ʻaʻole koʻikoʻi ka mea nui.

He aha nā ʻokoʻa ma waena o kēia mau mea he ʻelua?

E noʻonoʻo mākou iā lākou mai ka hoʻomaka ʻana o ke kaʻina hana assimilation a me ke ʻano o ka hoʻolaha ʻana, ʻoiai inā he mea hiki ke hoʻihoʻi ʻia kahi mea mai ke kino, a laila ʻo ia, ʻoiai me ke kaʻe, hiki ai ke kapa ʻia ʻaʻole kīnā ʻole.

ʻO ka hapa nui o ka sibutramine ma hope o ka lawe ʻana i ka waha e ka kino o ko mākou kino, a he nui loa kona mau ʻaoʻao, ʻoi aku ka maikaʻi o ka haʻalele ʻana i kona hoʻohana ʻana no nā poʻe i pilikia pilikia me ka puʻupaʻa a me nā aʻa. Eia kekahi, e hana ana i ka ʻōnaehana nūnaehana, hōʻemi i ka hoʻoliʻiliʻi ʻana, hana i nā poʻe makaʻala ʻole makaʻalili, hūnā, a me ka hiamoe. ʻAʻole makemake ʻia no nā poʻe e alakaʻi kaʻa i kēlā me kēia lā a kaʻa paha i kahi kaʻa o kēlā me kēia kaʻa.

Ua pālahalaha loa ka kiko o ke hana o kēia ʻano, no laila, ʻoi aku ka maikaʻi o ka hoʻopili ʻana i ka orlistat, kokoke loa loa ke ʻoki ʻia mai ke kino. Me ia, e hoʻolako i kahi lawelawe koʻikoʻi i ke kino, ʻoiai ʻo ia e hoʻomaʻemaʻe "i nā meaʻai a pau e komo ana i ka ʻōpū mai ka momona, akā aia pū kekahi no kā mākou lawelawe, no ka mea, ʻo nā mea maʻi āpau e lawe ana i nā hoʻomākaukau orlistat e hele pū me ka maʻi a me nā pilikia ʻē aʻe. ka ʻōpū. He ʻoi aku ka maikaʻi ma mua o sibutramine, no laila ʻo ka paʻa ʻana i loko o hoʻokahi kapsul e ʻoi aku ma mua o 100 mg (mai 120 mg).

ʻO kēlā me kēia lāʻau āu e koho ai, e hoʻomanaʻo mau ʻaʻole ia i aʻo ʻia e hoʻohana iā lākou me ke ʻole ke kūkā ʻana i kahi kauka!

Aia mau ka koho i kāu mau, akā ʻoi aku ka maikaʻi o ka hāʻawi ʻana i ke aloha i ka haʻuki a me ka meaʻai kūpono.

Kia olakino a hauʻoli.

Me ka pahuhopu e hoʻolilo i ka paona, nui nā kaikamahine a me nā wahine i nā lāʻau lapaʻau kūikawā e hoʻohemo i ka paona. Aia kēia mau papa i loaʻa ka sibutramine. Ma mua o ka hoʻomaka ʻana e lawe i kēlā mau hoʻomākaukau lāʻau lapaʻau, pono ʻoe e heluhelu i nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana i ka sibutramine i hāʻawi ʻia ma lalo nei.

Hōʻike ʻia i ka wā hāpai a me ka lactation

Hoʻololi ka poʻe loea i ka lawe ʻana i ka lāʻau lapaʻau i nā wahine i hiki i ka manawa hāpai a lactation paha. I kēia mau hihia, ʻaʻole e hoʻopili ʻia nā hopena o nā papa no ka makuahine wale nō, akā no kona wahine hoʻi. ʻAʻole hiki ke hoʻopoina ʻia kēia ʻōlelo aʻo, no ka mea ua ʻike ʻia nā maʻi he nui me ka olakino maikaʻi a ʻoiai i make.

Nā hopena hopena

ʻOiai e lawe ana i ka lāʻau lapaʻau e hōʻemi i ke kaumaha, hiki i kekahi mau hopena. Hiki iā lākou ke ʻelua o ka manawa pōkole a lōʻihi. Inā loaʻa he mea pono, pono ʻoe e hoʻomaopopo i ke kauka e pili ana iā ia, no ka mea, he pilikia o ka hoʻokaumaha ʻana i kou kūlana inā hoʻomau ʻoe e lawe i nā lāʻau.

ʻO ka papa inoa o nā hopena ʻaoʻao e pono ke komo:

• constipation
• lilo ka momona
• aloha
• ninini
• koko koko kiʻekiʻe
• poʻomanaʻo
• hopu hoʻohiwahiwa
• thrombocytopenia
• hoʻoholomua
• hoʻololi loli
• hopohopo
• āhāhuʻe
• ʻulaʻula i nā wahi like ʻole o ka ʻili,
• nephritis interstitial.

Hoʻopili pū me nā lāʻau ʻē aʻe

Loaʻa i nā loiloi o ka poʻe e nalowale ana i ka paona e pili ana iā Sibutramine e pili ana i kona pilina me nā lāʻau lapaʻau ʻē aʻe. I ka wā o ka mālamaʻana me kēia ʻaihue, ʻike pono i ka wā e hoʻohana ʻia ai nā papa like me ka erythromycin, ketoconazole, cyclosporine a me nā lāʻau lapaʻau ʻē aʻe e hoʻokaʻawale i ka hana o CYP3A4, hiki ke hoʻonui nui ʻia nā hōʻola o nā metabolits i ka plasma.

E hoʻonui ʻia ka loaʻa ʻana o ka maʻi serotonin syndrome i ka wā e lawe ai i ka Sibutramine a me nā lāʻau lapaʻau e like me kēia.

• opioid analgesics,
• Paroxetine
• Hoʻolālā
• pūnaʻuhū pio,
• "Citalopram".

E hoʻohana ma waho i waho

Hoʻohana nui ʻia nā lāʻau Sibutramine a me nā lāʻau like ʻole ma Russia wale nō. ʻO ka laʻana, ma nā United States nā huahana like mai ma lalo o ka inoa inoa "Meridia" a kūʻai wale ʻia aku e like me ke kuhikuhi e ke kauka. ʻO ka poʻe loea kūloko, kahi i hoʻokūkū i nā hoʻokolohua he nui i nā mea hana kauka me nā pae o ka ʻōpiopio. No kēia kumu, ʻae ʻia lākou e lawe ʻia i nā papa e nā poʻe maʻi maʻi ʻole i loaʻa nā pilikia olakino, ʻoi aku hoʻi me ka pūnaehana cardiovascular.

I ka European Union, ua hoʻokuʻu ʻia ka hoʻokuʻu ʻana o Sibutramine. ʻO ke kumu o kēia loaʻa ʻana e nā loea o ka hopena maikaʻi ʻole i ka hana o ka puʻuwai a me nā kīʻaha koko. I mea e wehewehe ai i kēia, ua loaʻa nā noiʻi like ʻole i nā poʻe e loaʻa ana i nā maʻi o kēia mau kino, kahi i ʻole hōʻoluʻolu ʻia nā hopena.

ʻAʻole hiki i kekahi poʻe ke kūʻai iā "Sibutramine", no laila ke noi nei lākou i nā lāʻau e like me ia i ka hōʻailona a me ka hana. ʻO ka mea pōmaikaʻi, he nui nā huahana like. Akā i ka manawa like, pono e hoʻomanaʻo ʻo ia nā kālā e loaʻa nei i nā sibutramine ua kūʻai wale ʻia ma ka hopena. ʻO ka mea kaulana loa o lākou:

1. Meridia Ke manaʻo nei i kahi lāʻau lapaʻau Kelemania i hoʻemi ʻia e ke kaumaha a hoʻomaʻamaʻa i nā kūlana psycho-emotional ka mea maʻi. Hoʻohana ʻia ia ma kahi kiko ma palena iki, ʻoiai e pono ia i kahi aho lōʻihi. Aia ka papa i kahi papa inoa he nui loa o nā hopena a me nā contraindications e hoʻopili ʻia ana i ka pilikia o ke ola o ke kanaka.
2. Slimia. Kūkulu ka lāʻau maikaʻi i ka hoʻemi ʻana i ke kaumaha o ke kino. Hiki iā ia ke hoʻolōʻihi i ka hoʻoliʻi lipid a hoʻopakele i ka mea maʻi i ka hilinaʻi ʻana i ka meaʻai. He kūpono loa ka lāʻau, akā ʻo ka papa o ke ʻano maʻi ma mua o ʻeono mau mahina.
3. "Obstat." He hāmeʻa i hoʻolālā ʻia e hoʻomau i ka paona, hana wale nō i kāna hana nui wale nō, akā i kekahi o nā mea hou aʻe. Hoʻopake ʻo ia i nā mea ʻai a hoʻohana ʻia wale no ka mālama ʻana i ka momona o morbid.
4. Lindax. Kūʻai nā kānaka i nā paila e hōʻemi i ka hilinaʻi ʻai. Kuhi nā kauka i kēia lāʻau lapaʻau e hana i nā loli i ka nohona ʻai inā hiki ʻole ke hoʻokipa i ka pōloli ma nā ala ʻē aʻe. Kahi ua mea ole raina ke mai a ʻaʻole ia e ae i ka hana o ke hilinaʻi i kāna mau ʻāpana.
5. ʻO Reducil. Hoʻohana nui ʻia kēia mea hana i kekahi mau'āina, akā e like me ka kuhikuhi a ke kauka. Kōkua ia i ka hakakā nui i nā paona ʻē aʻe, me ka hoʻoluhi ʻole ʻana.

ʻO ka hui ʻana o nā loiloi "Sibutramine" loaʻa pū kekahi. Kupanaha loa, i waena o lākou ʻaʻohe ʻōlelo no ka poʻe kūʻai aku, no ka mea, ua māʻona ka poʻe me kā lākou hana. ʻOiai paha nā hopena hopena, kūleʻa wale ka hopena o nā lāʻau lapaʻau. Mahalo i kēia, ʻaʻole like nā lihi o nā Sibutramine analogues. Loaʻa ʻia lākou a hoʻohana ikaika ʻia e nā poʻe ma nā ʻāina ʻē aʻe, e loaʻa ana nā hopena kupaianaha.

He pane kūpono

I kēia lā he mau ʻano loiloi e pau ana ka nui e pili ana iā Sibutramin. Ke waiho nei lākou e nā poʻe o nā makahiki like ʻole i loaʻa a i ʻole e hana ʻana i kēia lāʻau kūleʻa.ʻO nā mea kūʻai aku ma kā lākou ʻōlelo, hōʻike i kekahi mau hiʻohiʻona e hoʻokaʻawale i kēia mau peni mai nā lāʻau hoʻokūkū, me ka hana kūpono.

ʻO ka manawa pinepine, ua waiho ʻia nā loiloi e kēlā poʻe kūʻai mai ua loaʻa i ke kālā he nui a ʻaʻole hiki ke loaʻa ka hopena i makemake ʻia mai lākou. Hōʻike lākou ua hoʻemi wikiwiki ʻo Sibutramin i kā lākou makemake a kōkua i ka hōʻemi o nā paona mua mua loa i ke komo ʻana. ʻ saylelo aku nā mea hoʻohana pū, ʻaʻohe o nā hopena ʻaoʻao i ka hopena a i hōʻike ʻia no ka manawa pōkole, no laila ʻaʻohe kumu no ka hopohopo.

Kūʻai pinepine, hōʻike nā kānaka ma hope o ke ʻano o ka papa lapaʻau, ke kaumaha a me ka makemake ikaika ʻaʻole hoʻi e hoʻi. Mahalo i kēia, me ka nui o ka hoʻoikaika ʻole hiki iā ʻoe ke mālama kūpono a hoʻokō hoʻi i nā hopena hou, akā me ka ʻole o ka hoʻolilo kālā ma nā paila.

ʻO nā hopena ʻaoʻao o ka waiwai Sibutramine

Ma kahi noiʻi paʻa i ka pletebo, 9% o nā mea maʻi e loaʻa ana i ka sibutramine (n = 2068) a me 7% o nā mea maʻi e loaʻa ana i ka placebo (n = 884) i ka hoʻomau ʻia nei ka hana ma muli o nā hopena ʻaoʻao.

I nā haʻawina hoʻomokela i ka placebo, ʻo ka hopena maʻamau loa ka hopena o ka waha maloʻo, anorexia, insomnia, constipation, a me ke poʻo.

ʻO nā hopena hope loa i nānā ʻia i nā mea maʻi e lawe ana i ka sibutramine, me ka loaʻa o ka ≥1% a me nā manawa pinepine ma mua o ka hui pletebo. ʻO ka ʻike pinepine ʻia o kēia hopena hopena i ka hui e lawe ana i ka sibutramine i hōʻike ʻia ma ka inoa o ka inoa, ka ʻikepili like ʻole i ka hui placebo i loko o nā pūʻulu.

• ʻO ke kino holoʻokoʻa: hōʻeha - 30,3% (18.6%), ʻehaʻeha - 8,2% (5.5%), maʻi like ʻana o ka maʻi maʻi - 8,2% (5.8%), hōʻeha kūwaho - 5.9% (4.1%), asthenia - 5.9% (5.3%), ʻehaʻeha - 4.5% (3.6%), ʻehaʻeha - 1,8% (1,2%), ʻeha i ka ʻāʻī - 1,6% (1.1%), nā hopena kūlohelohe - 1,5% (0.8%).
• Mai ka pūnaehana cardiovascular a me ke koko (hematopoiesis, hemostasis): tachycardia - 2,6% (0.6%), vasodilation (ka holo ʻana o ka ʻōpū me kahi manaʻo o ka mahana) - 2.4% (0.9%), migraine - 2.4% (2.0%), hypertension / hoʻonui i ke koko - 2.1% (0.9%), puʻuwai puʻuwai - 2.0% (0.8%).
• Mai ka hāliʻi ʻana o ka huina: anorexia - 13.0% (3.5%), constipation - 11.5% (6.0%), hoʻonui nui momona - 8.7% (2.7%), nausea - 5.9% (2.8 %), dyspepsia - 5.0% (2.6%), gastritis - 1,7% (1,2%), make wai - 1,7% (0.9%), huʻi - 1,5% (1 , 4%), exacerbation o nā ʻōpū - 1,2% (0.5%).
• Mai ka ʻōnaehana musculoskeletal: arthralgia - 5.9% (5.0%), myalgia - 1,9% (1.1%), tendosynovitis - 1,2% (0.5%), nā maʻi hui - 1.1% (0.6 %).
• Mai ka pūnao a me ka hoʻonaninani naʻauao: hau maloʻo - 17.2% (4.2%), insomnia - 10,7% (4,5%), dizziness - 7.0% (3.4%), nā huhū - 5.2% (2, 9%), hopohopo - 4.5% (3.4%), ke kaumaha - 4.3% (2,5%), paresthesia - 2,0% (0.5%), ka hiamoe - 1,7% 0.9%), ʻala - 1.5% (0.5%), ka hana naʻau - 1,3% (0.6%), he hoʻololi i ka ʻono - 2.2% (0.8%), nā maʻi pepeiao. 1.7% (0.9%), kaʻimi pepeiao - 1.1% (0.7%).
• Mai ka papa hana hanu: rhinitis - 10,2% (7.1%), pharyngitis - 10,0% (8.4%), sinusitis - 5.0% (2.6%), hoʻonui pāhau - 3.8% (3.3 %), laryngitis - 1,3% (0.9%).
• Ma ka ʻāpana o ka ʻili. kalohi - 3.8% (2,5%), honu - 2,5% (0.9%), Herpes simplex - 1,3% (1.0%), huihui - 1.0% (0.8 %).
• Mai ka pae genitourinary: dysmenorrhea - 3,5% (1,4%), maʻi maʻi urinary - 2.3% (2.0%), candidiasis vaginal - 1.2% (0.5%), metrorrhagia - 1.0% (0 , 8%).
• Nā ʻili: ʻO ka edema maʻamau - 1.2% (0.8%).

ʻO ka hoʻomaʻamaʻa ma mua, i ka wā a ma hope o ka wā hāpai

I kekahi manawa ʻo ke kīpopeka ke kumu o ka nānā ʻana o ka hormonal i nā wahine, ke pale aku i ka wahine hāpai, hapai a me ka hānau ʻana o kahi pēpē maikaʻi. Pono ke kūlana i ka mālama ʻana i ka meaʻai a me ka hoʻōla ʻana. Inā ʻaʻole pono nā ʻano ʻē aʻe o ka hoʻoponopono ʻana i ka paona, hiki ke kuhikuhi ʻia ka sibutramine ma mua o ka wā hapai. Pono ia e noʻonoʻo pono ka hopena o ka lāʻau i ka hopena teratogenic, ʻo ia hoʻi, e hiki ke hoʻonāukiuki i nā anomalies i ka hoʻomohala ʻana o ka pūpū.

No ka manawa holoʻokoʻa o ka mālama ʻana, pono ka wahine i hāʻawi i ka ʻukena ʻokoʻa. Mai ka hopena o ka papa o ka mālama ʻia a hiki i ka manawa kūpono, a ʻelua mau mahina e hala. I ka wā hana o kēia manawa, e hoʻopau ke kino i ke koena o ka waihona lāʻau. Kūʻai ʻia me ka lāʻau lapaʻau i ka wā hāpai a me ka umauma.

ʻO nā huaʻelima piha o Sibutramin he mau lāʻau lapaʻau:

ʻO nā puka holomua o Sibutramine he Goldline Plus a me Reduxine Met.Ma kahi o ka mea hana, hoʻopili ʻia ka cellulose microcrystalline i kā lākou hui, ka mea e hoʻoikaika ana i ka hopena anorexigenic o sibutramine. Hoʻopili pū kekahi ʻo Reduxin Met i ka metformin, he mea hōʻeuʻeu i ka ʻike ʻana o nā ʻōpū o ke kino i ka insulin.

Pōʻino nā mea āpau āpau i nā ala like ʻole e hōʻino ai ka sibutramine, loaʻa nā contraindications like a me nā hopena ʻaoʻao. ʻAʻole he kīhāpai kaiʻai ʻo Goldline Light i ka sibutramine, no laila ʻaʻole hiki ke hoʻohālikelike ʻia me ka lāʻau lapaʻau mua.

Ma waena o nā mea pono no ka sibutramine, ʻo Xenical ka mea kaulana loa. ʻO kāna ʻano kūpono, orlistat, ʻo ia ka nui o ka lāʻau lapaʻau loiloi no ka hoʻolilo ʻana i ka momona me ka palekana a me ka hana pono. Hoʻohana wale ka mea i loko o ka lumen intestinal, kāohi i ka hoʻopili ʻana o nā momona, a ʻaʻole i hoʻopilikia i ka pūnaehana nū waena.

Nui ka nui o nā poʻe no kahi kumu hoʻokahi a maʻi ʻē aʻe paha i ka kaumaha nui. ʻAʻole maʻalahi ka maʻalahi e haʻalele iā ia. ʻO ke ʻano, ʻaʻole ke koho maikaʻi ʻana nā meaʻai. Eia kekahi, he mea i hoʻopiʻi ʻia e pono i hiki mai i nā ʻōlelo me kekahi mau palena, a e hoʻolako pū kekahi i kekahi manawa i kēia kaʻina hana, pono e loaʻa i ka makemake makemake. ʻO ia ke kumu i hoʻolohe ai i nā poʻe he nui i nā lāʻau lapaʻau, kūikawā, ka lāʻau lapaʻau Hoʻopauwa Lokalaka .

Ke ulu nui nei ka nui o nā poʻe e luhi i kēlā me kēia makahiki. Ka mea, ke hoʻonui nei o ka pilikia. ʻAʻole ke kau momona nui wale nō ka pilikia o nā hiʻohiʻona. Hoʻopilikia kēia i nā meaʻeha ʻole e kūlohelohe ai: hoʻohui pū kekahi ke pili i kāna kiʻi. Ua mamao loa ia no ka hiki ʻana i ke kau ʻana i ke kau nui, ʻoiai inā ʻoe e komo i ke ʻano haʻuki i kēlā me kēia lā a ʻai pololei. ʻO ia ke kumu e kaukaʻi ai nā kauka i nā lāʻau lapaʻau, kūikawā, ʻo Sibutramine.

Ua kau ʻia ʻo Sibutramine i nā poʻe e ʻeha a kaumaha loa i nā momona. Ma kēia hihia, ʻo kekahi o nā kūlana koʻikoʻi ʻo ia ka nele o nā hopena i ka wā e hoʻohana ai i nā hana ʻē aʻe o ka nalowale ʻana o ka paona, no ka laʻana, e pili ana i ka meaʻai kūpono, nā meaʻai, i ke ʻano hana maʻamau a me ka hana kino. ʻOiai ka hana kūpono o ka lāʻau Sibutramine a ma hope o kāna papa ke ʻike ʻia kahi hopena maikaʻi, pono ia e hoʻomaopopo pono he mau lāʻau maikaʻi kēia mau papa.

Eʻoluʻolu: E like me nā maʻi'ē aʻe he nui, ʻo Sibutramine kona mau hopena a me kekahi mau contraindications.

Hoʻohana wale ʻia ʻo Sibutramine, e like me kekahi lāʻau lapaʻau, ma hope o ke kūkā ʻana me ke kauka alakaʻi, ʻo ka hoʻohana ʻana iā ia me ka hiki ʻole ke alakaʻi i nā hopena ʻaoʻao a me kahi overdose. Ma ka holoʻokoʻa, he nui nā loiloi o ka lawe ʻana i ka momona e pili ana iā Sibutramine. Ma hope o nā mea āpau, e like me nā lāʻau lapaʻau he nui, ʻaʻole kūpono ia i kahi kanaka.

Hoike ʻike

Ua puka aku kēia lāʻau lapaʻau ma mua o ʻelua mau makahiki i hala. He hopena koʻikoʻi ʻo Sibutramine no ka mālamaʻana i ka momona a me ke kaumaha. Pono ia e hoʻomaopopo no ka nalowale ʻana o ke kaupaona ʻana wale nō ke lawe ʻia kēia mau peni. Hāʻawi ʻia ʻo Sibutramine e hoʻohana wale ʻia me ka hui pū me kahi loina maʻamau i mālama ʻia, a me ke ʻano maʻamau a hoʻonui pinepine i ka hoʻoikaika kino.

ʻO ka mea mua i manaʻo ʻia ma hope o ka lawe ʻana i nā papa Sibutramine he ʻano o ka piha piha. ʻOiai inā ʻoe e ʻai i kahi liʻiliʻi o ka meaʻai, ua lawa ia no ke kino a e piha. - ʻO ia kekahi o nā mea nui a Sibutramine. Hana ʻia kēia ma muli o kona hopena i ka ʻāpana o ka lolo i kuleana no ka satiety. Ka mea, ke alakaʻi nei kēia i ka mea eʻai nui ka mea maʻi i ka meaʻai, ua ʻili ʻia nā mālama a me nā momona o ke kino.

Hoʻohana lākou iā lākou e hoʻohana i kēia lāʻau lapaʻau i ka hopena ʻaʻole i loaʻa nā hopena ʻē aʻe i ka nalo ʻana. Aia i kēlā mau hihia kūʻokoʻa i aʻo ʻia e nā kauka ke lawe i nā papa Sibutramine. I ka wā o ka papa mālama lapaʻau holoʻokoʻa, pono ka mea maʻi ma lalo o ka mākaʻikaʻi o ke kauka i loea i nā pilikia ʻeha.

Eia kekahi, pono e hoʻihoʻi ʻia i kēia mau hana:

• nā meaʻai pilikino kūʻokoʻa,
• hoʻoponoponoʻia o ke ʻano ola a me kekahi mau hana,
• hoʻonui i ka hana kino, haʻuki.

Ka Hoʻomaka Kaila

I ka wā mua, ua hana ʻia kēia lāʻau lapaʻau ma ʻAmelika Huipū ʻia, akā i kēia lā ua pāpā ʻia no ka hoʻohana ʻana ma nā ʻāina e like me Kanada, Europe, Australia, ʻAmelika Hui Pū ʻIa. ʻO kēia no ka hopena o ka hopena maikaʻi o ka sibutramine ma ka ʻōnaehana cardiovascular i hōʻoia ʻia. I Lūkini, kahi lāʻau lapaʻau, e like me kona analogues, hiki ke kūʻai ʻia i ka hale kūʻai ma o ka lāʻau lapaʻau wale nō. E hana ʻo ia i ka papa inoa o nā lāʻau lapaʻau. Eia nō naʻe, ua kuhikuhi ʻia i ka waiho wale ʻana o ka hopena o ka lāʻau a me ka hana kino.

Hoʻololi paha nā kaikamahine i kēia mau wā i ka kaumaha a loaʻa nā hope. Ke hele ʻole nei i ka pahuhopu, ʻaʻole ia he mea maʻalahi loa, akā ʻo nā ʻano lāʻau like ʻole nā ​​mea kōkua maikaʻi loa i ia mea. Hōʻike nā loiloi i ka emi ʻana o ka kaumaha ma "Sibutramine" e hōʻoia maikaʻi ana kēia mau paila. E kōkua ana kēia mea hana e nalowale i ke kaumaha me ka wikiwiki, akā aia wale nō i ke kānāwai no kona hoʻohana a mālama a.

Ma ke aʻo ʻana e pili ana i ka hopena o ka lāʻau lapaʻau, makemake nui nā kānaka i nā ʻōlelo a me nā loiloi e pili ana i ka "Sibutramine." I ka ʻoiaʻiʻo, ʻokoʻa ia mai kona hoʻokūkū i kekahi mau hiʻohiʻona i hōʻike ʻia i ka noi. Inā ʻole ʻoe e hoʻokō i nā lula i ʻōlelo ʻia i loko o nā ʻōlelo kuhikuhi, ʻaʻole pono ʻoe e helu i kahi hopena kūpono, akā hiki koke iā ʻoe ke hōʻemi i kou olakino ponoʻī ma kēia ala.

Ma ka ʻatikala e hiki ke loaʻa i ka ʻike e pili ana i ka mea hea ka lāʻau lapaʻau. Nā Kūmole o Sibutramina, nā ʻōlelo no ka hoʻohana ʻana a me nā loiloi - e ʻoluʻolu kēia a pono no nā wahine a me nā kāne ʻaʻole i ʻoluʻolu me ko lākou kiʻi.

Nā ʻōlelo kikoʻī

Hiki ke noi ʻia i nā hihia wale nō kahi hana pono ʻole e hōʻemi i ke kino. Pono e mālama ʻia ka lāʻau lapaʻau ma lalo o ka mākaʻi o ke kauka me ka ʻike ma ka hoʻoponopono ʻana i ka momona me he ʻāpana o ke ʻano paʻakikī (kaʻai, ke hoʻololi ʻana i ka ʻai a me nā ʻano hana, hoʻonui i ka hana kino). Pono ka palena o 15 mg i ka manawa.

ʻO ka hopena o ka sibutramine ma ke kino

Hoʻohālike ka Sibutramine me ka amphetamines, ʻoiai ʻaʻole ia i hāʻawi ʻia me ko lākou mau mea ola. He centrally hana ia, he mea hoʻomalu i ka reuptake o serotonin, norepinephrine a me dopamine.

No laila, ʻo ka hopena o ka sibutramine ma ke kino e hōʻemi ana i ka hoʻopau ʻana i ka pōloli ma o ka hoʻonui ʻana i ka ʻike o ka serotonin i loko o ke kino. ʻO ka lawe ʻana i nā lāʻau me ka sibutramine e hoʻopau ai i ka momona, hoʻāla i ka naʻau wikiwiki, hōʻemi i ka pono o nā huapalapala, ke wikiwiki ʻana i nā kaʻina metabola - ʻo ke kino hoʻomaka ka hoʻohana ʻana i kāna mau momona momona, a hoʻāla pono ka pūnao i nā glucose.

Ma hope o ka lawe ʻana i ka sibutramine, ua hoʻopili maikaʻi ʻia i ka hoʻopili ʻana a me ka hoʻoliʻiliʻi i loko o ka ate me ka hoʻokumu ʻia o nā mea ikaika. ʻO ka ʻike nui loa o ka waiwai ikaika i ka plasma ua hoʻomaopopo ʻia i hoʻokahi a me ka hapa mau hola ma hope o ka lawe ʻana i ka lāʻau lapaʻau, nā metabolites ikaika - ma hope o ʻekolu mau hola.

ʻO nā waiwai Pharmacological

Hoʻopili ʻo Sibutramine i ka hana hou o ka neurotransmitters (norepinephrine a me serotonin) mai nā kāpae synaptic, hoʻomaikaʻi i nā hopena synergistic o ka pūnaehana serotonergic a me nā norepinephrine pūnao. Hoʻemi i ka nui o nā meaʻai i hoʻopau ʻia a me ka makemake (e hoʻonui ai i ka ʻōpū piha), pili i ka kiko adipose brown, hoʻonui i ka thermogenesis (ma muli o ka hana kūlohelohe o nā mea hoʻonā beta3-adrenergic). Hoʻokumu ka Sibutramine i nā metabolites ikaika i loko o ke kino, ʻo ia ka mea e keu nui ai i kona hiki ke pale aku i ka reuptake o norepinephrine a me serotonin. Eia kekahi, hoʻopaʻa ʻia kēia mau metabolites i ka hoʻomaʻemaʻe ʻana o ka dopamine, akā 3 mau manawa nāwaliwali ma mua o norepinephrine a me serotonin. ʻAʻole hoʻopilikia ʻo Sibutramine me nā metabolites ikaika i ka hana a MAO a me ka hoʻokuʻu i nā monoamines, ʻaʻohe hopena antihistamine a me nā anticholinergic hopena, a ʻaʻole i launa pū me nā neurotransmitter receptors (me ka adrenergic, serotonergic, benzodiazepine, dopaminergic a glutamate). Hoʻopili ʻo Sibutramine i ka hana ʻana o ka sereletonin a hiki ke loli i ka hana o ka platelet. Me ka hoʻohaʻahaʻa ʻana i ke kaupaona o ke kino i ka serum koko, hoʻonui ʻia ka maʻi HDL a me ka nui o ka nui o ka kolamu, triglycerides, uric acid a me LDL e hoʻemi ana.

I ka wā sibutramine therapy, hoʻomaha iki i ke kahe koko (e 1-3 mm Hg) a me ka pulse nui me ka nui (e 3-7 beats / min), akā i kekahi mau manawa i ʻōlelo ʻia ai kēia mau loli. Ke hoʻohana nei i ka sibutramine me nā mea paʻa o ka microsomal oxidation, ke hoʻonui nei ke kiko QT (e 9.5 ms) a me ka nui o ka pulse (e 2.5 bpm) i hoʻonui.

ʻAʻole hōʻike ʻia kahi hōʻike ma nā kiʻi a me nā kahe o ka carcinogenic, mutagenic, teratogen effects a me nā hopena e pili ana i ka hoʻouka sibutramine, ua hoʻonui ʻia ka ulu ʻana o nā hua benign o ke ʻano interstitial o nā hōʻike. Akā i nā haʻawina e pili ana i nā huaʻilaka, ua hōʻike ʻia nā hua e anomalies i ka ulu kino (hoʻololi i ka nui a i ʻole ke ʻano o ka huelo, auricle, muzzle, mānoanoa o ka iwi).

Ke lawe waha ʻia, lawe koke ʻia ka sibutramine i ka ʻeha gastrointestinal ma kahi o 77%. I ka "papa mua" ma o ka puʻuwai, biotransformed ka lāʻau me ke komo ʻana o ka isoenzyme CYP3A4 o ka cytochrome P450 me ka hoʻokumu ʻana o nā metabolites mākaʻi (di - a me monodesmethylsibutramine). Ke lawe nei i 15 mg o ka lāʻau lapaʻau, ʻike nui ʻia ka nui o ka monodesmethylsibutramine ma aneane 4 ng / ml, didesmethylsibutramine kahi awelika o 6.4 ng / ml. Loaʻa ka ʻike nui o ka sibutramine ma hope o nā hola 1.2, ʻo kāna mau metabolite hoʻonaninani ma hope o 3-4 mau hola. Co-hoʻokele o ka lāʻau lapaʻau me ka meaʻai e hōʻemi i ka nui o ke kaila o nā metabolites ma o 30% a hoʻonui i ka manawa e hōʻea iā ia i nā hola 3, ʻoiai ʻaʻole i loli ka AUC. ʻO ka kūlike o ka kūlike i loko o ke koko o nā metabolites ikaika o ka sibutramine i loaʻa i loko o 4 mau lā ma hope o ka hoʻomaka ʻana o ka lapaʻau ʻana a ma kahi o 2 mau manawa nui aʻe ma mua o ka maʻi o ka plasma ma hope o ka lawe ʻana i hoʻokahi maʻa. Hoʻolaha nui ʻo Sibutramine i nā kiko āpau. Hoʻopili ka Sibutramine i nā protein protein ma 97%, kāna mau metabolite kūlohelohe - e 94%. ʻO ka hapalua o ka ola sibutramine ʻo 1,1 hola, didesmethylsibutramine - 16 mau hola, monodesmethylsibutramine - 14 mau hola. Hoʻokomo ka metabolites ola i ka conjugation a me ka hydroxylation me ka hoʻokumu ʻana o nā metabolites i ʻole e hana ʻia, ka mea i hoʻopili ʻia e nā keiki.

Hoʻolohe Mai 2010, sibutramine a me nā hoʻomākaukau e pili ana i ia mea ua pāpā ʻia i ke kūʻai aku ma ʻEulopa, ka USA, Kanada a me Australia ma muli o ka hōʻoia i ka hopena pathogen ma ke ʻano o ka ʻōnaehana pili. Manaʻo ʻo EMEA e kuhikuhi i nā kauka i nā mea hou aku i ka sibutramine, ʻaʻole i hoʻokuʻu nā mea lāʻau lapaʻau, a makemake koke nā poʻe maʻi e ʻike i ke kauka no ka hoʻololi i ka lāʻau lapaʻau.

ʻO ka launa kākoʻo kākoʻo piha loa no ka poʻe maʻi e kauhuhu i ka momona alimentary me ka body mass index o 30 kg / m2 a i ʻole a i ʻole a me kahi kiko kino kino o 27 kg / m2 a i ʻole, akā i mua o nā mea'ē aʻe e pili i ka nui o ke kaumaha o ke kino ( dyslipoproteinemia, type 2 diabetes mellitus).

Nā Hoʻohui

Hypersensitivity, bulimia nervosa a anorexia nervosa, ka hele mai o nā kumu kūlohelohe o ka momona, Gilles de la Tourette syndrome, maʻi maʻi kanaluna, peripheral, hana hewa ka naʻau, ʻeha noʻonoʻo, maʻi maʻi coronary, puʻuwai naʻau congenital, arrhythmia, tachycardia, hipertension o ka pehu / 90 mmHg), maʻi maʻi cerebrovascular (transient cerebrovascular accident, stroke), hōʻemi nui ʻana i ka hana ma ke ʻano o ka palaki a i ʻole nā ​​puʻupuʻu, nā maka coma, hyperthyroidism, pheochromocytoma, benign prostatic hyperplasia, i hui pū ʻia me ka piha ʻana o ka urine i waiho ʻia, ka lāʻau lapaʻau, ʻona a me ka hilinaʻi waiʻona, kaʻana a i ʻole he manawa liʻiliʻi ma mua o 2 mau pule ma hope o ka hoʻihoʻi ʻana o ka MAO inhibitors a iʻole nā ​​lāʻau lapaʻau e hana ana i ka pūnaehana nūnū. a me nā antidepressants, antipsychotics, tryptophan), a me nā lāʻau ʻē aʻe e hōʻemi i ke kaumaha o ke kino.

ʻO nā inoa kalepa no nā lāʻau lapaʻau me nā mea waiwai sibutramine

ʻO Sibutramine, a me kona mau kikoʻī nīna i nā ʻatikala like ʻole me ka hopena psychoactive, i loko o ka "papa inoa o nā mea waiwai nui no nā kumu 234 a me nā ʻatikala e pili ana i ka Criminal Code of the Russian Federation", i ʻāpono ʻia e Nā Decree of the Government of the Russian Federation of December 29, 2007 N 964. ʻO ka Manaʻo i ka papa inoa e hōʻike nei. ua helu ʻia nā ʻano āpau āpau, no ka mea (inoa) ka inoa a lākou i koho ʻia, ke komo pū ʻia me nā mea pili i kēia papa inoa i hui pū ʻia me nā mea hoʻohana ʻole i ka lāʻau lapaʻau. ko papa inoa. Ma Lūkini, hiki ke kūʻai ʻia nā lāʻau lapaʻau ma ke ʻano me ka papa lāʻau a ka lāʻau lapaʻau wale nō inā he laikini lākou no nā hana lapaʻau me ka pono e hana me nā mea momona a me nā mea momona, e like me nā papa PKKN.

ʻO ke papa o ka lawe ʻana i nā lāʻau lapaʻau e pili ana i ka sibutramine waiwai

Pono ka Sibutramine no ka hoʻolilo kau ʻana e hana ma muli o nā ʻōlelo kuhikuhi. Wahi a nā mea hana mai nā lāʻau lapaʻau e makemake i ka minamina dull, lawa ka lawe he 10 mg o ka sibutramine i kēlā me kēia lā. I ka manawa like, ʻōlelo lākou e hoʻemi i ka helu calorie intake i kēlā me kēia lā e 20% a hana i ka hana pilikino i kekahi manawa i ka hebedoma.

ʻO ke kumu o ka lawe ʻana i nā kālā e pili ana i kēia hana ikaika - he lōʻihi a mai ka ʻekolu a ʻeono mau mahina, i kekahi mau kūlana ua hiki i hoʻokahi makahiki. Hiki ke hoʻohana ʻia ka sibutramine i nā hihia ʻaʻole hiki i ka mea maʻi ke hōʻemi i ka paona me ke kōkua o ke olakino a me ka meaʻai. ʻO ka maʻamau, ma mua o ka koho ʻana i nā lāʻau lapaʻau e hoʻoikaika i ka hana o ka serotonin, kau ka mea maʻi i ka papaʻai, nānā iā ia no kekahi manawa. Inā ʻaʻole maikaʻi ka hoʻololi i kaʻai ʻana no ka pau ʻana o ka paona, ua kau ʻia kahi lāʻau lapaʻau me ka sibutramine.

He aha ka sibutramine pilikia: nā hopena a me nā hopena

ʻO Sibutramine no ka hoʻolilo kauʻana he mea lapaʻau maʻamau maʻamau, eia naʻe, ma nā loiloi he nui, pau nā kaikamahine momona a me nā loea lapaʻau e kapa i kēia mea ʻona a me ka lāʻau ikaika. ʻO nā mea hana i kēia huahana pharmacological ma nā ala āpau e hōʻole i kēia ʻike a ka lehelehe i ka sibutramine ma ke kānāwai ma lalo o nā inoa kālepa like ʻole.

He aha ka pilikia o ka sibutramine a he hopena maikaʻi paha ia i ke kino o ke kanaka? Hoʻomaopopo i ka manaʻo o ka mea ikaika e hoʻopili i ka lolo, hiki i ka hopena hopena o kēia ala ke emi ai ka kaumaha.I waena o nā hopena koʻikoʻi maʻamau o sibutramine, kāhea ka poʻe loea i ka maʻi cardiac a me ka noʻonoʻo. ʻO ka pōpilikia a me ka hopena kānalua o ka huahana a me ka hoʻopihapiha e like me ka hoʻopili ʻana i hōʻoia ʻia e ka mea i pāpā ʻia i ka nui o nā ʻāina ʻEulopa.

Ua hoʻāʻo mua ʻia ʻo Sibutramine e hana i mea no ka hōʻeha ʻana i ke kaumaha, akā naʻe, ʻaʻole i loaʻa kahi hopena maikaʻi. Akā i ka wā o ka hoʻokolohua, ua ʻike ʻia kona hiki ke hoʻohiolo. Mai ia manawa, ua hoʻohana ʻia nā sibutramine. Nui nā mau ʻāina i pāpā ʻia ai ka lāʻau. No laila, ua kāpae ʻia ka hāʻawi ʻana i nā ʻāina CIS.

ʻO ka hoʻohanaʻana i ka lāʻau lapaʻau ka hopena paha i nā hana ʻē aʻe no ka lilo ʻana o ka paona i hāʻawi i kahi hopena. Hoʻohana ʻia ka Sibutramine i ka hui pū me ka hana a me ka hana kino. No laila e loaʻa mai ai nā hopena hou aʻe:

• ʻOhi ʻaū
• Hoʻomaka kūlohelohe i ka momona kino,
• Ka hana ana o ka hana serotonin, e kōkua ana i ka maikaʻi leo,
• Hoʻemi i ka salivation a me ka mākaukau e hoʻomohala i nā ʻoka,
• Ma ka hopena o ka hopena maikaʻi, hōʻemi ka paona mai 7 a 15 kg i ka malama.

Pehea e hoʻohuli ai i sibutramine

ʻO nā lāʻau lapaʻau no ka pohō kaumaha: