ʻO Diroton a i Lisinopril paha - ʻoi aku ka maikaʻi? Nā mea huna hope!

Nā Diroton - he mau papa kēia e hōʻemi i ka hoʻokumu ʻana o ka angiotesin II mai angiotensin I, e hoʻemi ana i ka hōʻemi o ka bradykinin a hoʻonui i ka synthesis o prostaglandins. Kēia hopena hopena o ka lāʻau lapaʻau ma ke kino e kōkua i ka hōʻemi ʻana i ka OPSS, ke koko, ka mana a me ka paipai i nā pulillary pulmonary. Hoʻohui, hiki i ka lāʻau lapaʻau ke hōʻeha i ka nui o ka minuke o ke koko a hoʻonui i nā ʻāpana.

Hiki i ka Diroton, e like me kona analogue, hiki ke hoʻolōʻihi i ke ola o nā mea maʻi me ka puʻuwai naʻau maʻi a hoʻolohi i ka hoʻomohala ʻana o ka hana hōʻino hema hema i loko o nā mea maʻi ma hope o ka infococote myocardial.

ʻO ka mea hana ikaika ma ka ʻano hana o Diroton ʻo lisinopril. Nui ka hoʻohālikelike o ka lāʻau lapaʻau no ka mea ikaika. ʻO ka nīnau: "He aha ka mea e hoʻololi ai iā Diroton?" Kū pinepine ke ala i ka poʻe maʻi a contraindications no ka lawe ʻana i ka lāʻau lapaʻau, no laila e kamaʻilio mākou e pili ana i nā mea kūlike.

He like a like me ka Lisinopril a me Diroton. Hoʻokuʻu ʻia lākou ma nā ʻano like - nā papa o 5 mg, 10 mg a me 20 mg, a lawe ʻia i hoʻokahi manawa i ka lā, me ke ʻano o ka komo ʻana o ka meaʻai. Akā ʻo Diroton wale nō e hoʻopau i ʻelua mau manawa he nui - 10 mg hoʻokahi manawa i ka lā, a me Lisinopril wale nō 5 mg. I nā kūlana ʻelua, loaʻa ka hopena piha i ka pule ʻelua a ʻehā paha.

ʻO nā ʻokoʻa nui he contraindications, no ka mea ua pāpā ʻia ʻo Diroton no ka poʻe maʻi me ka edema mehana ʻo Quincke, a me Lisinopril no ka poʻe maʻi maʻi intolerant lactose, me ka hapa o ka lactose, a me ka malabsorption glucose-galactose hoʻi. ʻO ke koena o nā contraindications e lawe i ka lāʻau lapaʻau e like nō ia.

• hapai
• lactation
• ka moolelo o ke angioedema,
• hypersensitivity i ka lāʻau.

ʻO ka waiwai kumu i enalapril he enalapril - ʻo ia ka mea nui i waena o nā lāʻau. Eia kekahi, loaʻa i ka lāʻau lapaʻau ka kikoʻī liʻiliʻi o nā hopena, ʻaʻole like me Diroton e hoʻohana wale ʻia nō nā maʻi ʻelua.

• haehae maʻi
• nāwaliwali o ka puʻuwai.

ʻAʻole hiki ke paʻa hewa i ka hoʻohana ʻana i ka hana like ʻole o ka hana lōkia, ma hope o ka hoʻololi ʻana i ka pēpē lace a me ka hyperaldosteronism primer. ʻO nā contraindications i koe ke kūlike me Diroton.

ʻOkoʻa ʻo Diroton lāua ʻo Lozap i ka mea ikaika, no ka mea, aia ʻo Lozartan. No ka mea, ua hoʻohana ʻia ka lāʻau lapaʻau e mālama i nā mamao o nā maʻi āpau, akā me ka hypertension a me ka pohō o ka naʻau. I kēia hihia, ua like nā contraindications o nā lāʻau. No laila, hoʻololi ʻia ʻo Diroton e Lozap i nā hihia i ʻike ʻia ai ka maʻi maʻi i ka lisinopril.

Ma ka hōʻuluʻulu ʻana, hiki iā mākou ke ʻōlelo pono i kēlā me kēia lāʻau lapaʻau pono iho. Hoʻohālikelike ʻia nā kikoʻī o Diroton e nā contraindications a i ʻole ka mea kaha a lilo, ʻo ia ka mea i lilo ka mana koʻikoʻi i ka koho ʻana i kahi lāʻau.

Wahi a ka papa helu laila ʻo ka lāʻau lapaʻau, aia ʻo Diroton i ka hui o ka angiotensin-e hoʻohuli nei i ka hoʻohui o enzyme, a i ʻole nā ​​mea i hoʻopaʻa ʻia ka ACE inhibitors.

Hoʻohana ʻia lākou no nā pālahalaha o nā maʻi like, e komo pū ana me ka atherosclerosis asymptomatic, hana heʻōmaʻomaʻo, kahi mea i hōʻike ʻia e ka albuminuria.

Akā ʻo nā hōʻailona kumu nui no ke koho ʻana i kēia mau lāʻau lapaʻau nā ala āpau o ke ʻano o ka pūnaʻi cardiovascular, i hele pū me ka hypertension arterial me ka pōʻino o ke koko peripheral, arrhythmias

ʻAʻole ia e like me nā lāʻau lapaʻau ʻē aʻe i kuhikuhi ʻia e nā cardiologists no ka mālama ʻana i kēlā mau maʻi, ʻo Diroton, e like me nā ʻili a nā kūloko a me nā haole ʻokoʻa mai ka hui o ACE inhibitors, ʻaʻole ia i hoʻopaʻa ʻia i ka hypoglycemia, no laila hiki ke palekana palekana no ka maʻi maʻi maʻi.

No ka hoʻomaopopo ʻana i ka kaina o ka hana a ka lāʻau lapaʻau, e noho mākou ma nā hana o ka ʻōnaehana renin-angiotensin-ald testosterone a me kāna hana i ka hoʻoponopono o ke koko.

E like me ka inoa o ka hui lāʻau lapaʻau e pili ana iā Diroton, ʻo kāna hana loina lisinopril e hōʻemi nei i ka hōʻemi o ke kiʻekiʻe o ka ACE i nā kaila a me nā ʻili a pale i ka hoʻololi ʻana o ka angiotensin I kahi kūlana hoʻoikaika, angiotensin II, e hoʻolei nei i ka kahe o nā hopena i hōʻike ʻia ma luna nei.

No laila, ʻo Diroton ka ʻōlelo kikoʻī o ka hana e hoʻemi i ka hōʻike ʻana o ka hypertension arterial, maʻi naʻau coronary, ʻehaʻeha naʻau.

Hāʻawi kāna waiwai lisinopril i ka hopena aʻe o ka lāʻau lapaʻau ma ke kino:

• Antihypertensive.
• ʻO ka Vasodilating a me ka pleiotropic. ^ E Ha yM. Hoʻopili ka Diroton i ka hana o ka hoʻoneʻe o ka kinase II a hoʻonui i ke kao o ka bradykinin. Hoʻopili kēia i ka normalization o ka endothelium moku koko, hoʻonui i ke kāpiliʻana o ka nitric oxide. Ke loaʻa pū ka lāʻau lapaʻau i ka hopena anti-inflammatory, e hōʻemi i ka pae o ka protein C-reactive a me fibrinogen.
• Hoʻopau i nā kahe koko i loko o ka puʻuwai a me nā kino ʻē aʻe, kahi e hōʻemi nui ai i nā hōʻeha o nā hoʻopiʻi me ka hypertension arterial.
• Cardioprotective. ^ E Ha yM. ʻO ka inhibitor ACE e hoʻoulu i ka hoʻoulu hou ʻana o ka hypertrophy ventricular hema o ka puʻuwai, a me kēia hōʻailona he mau lela no kahi hoʻomaʻemaʻe ʻole makemake o nā pathologies cardiovascular. Hoʻonui hoʻi ʻo Diroton i ka pīhoihoi a me ka nui o ke koko, e hoʻoneʻe i ka pre- a ma hope o ka myocardium, e kōkua ana e hoʻihoʻi i kona ikehu a me ka hana ʻana me ka ʻole o ka hoʻonui ʻana i ka puʻuwai. Hoʻonui kēia i ka holomua o ka hiki ʻole o ka naʻau puʻuwai ma kahi maʻi a hoʻonui i ka pale ʻana i ka hoʻoikaika kino.
• Diuretic. ^ E Ha yM. Hoʻokuʻu ʻo Diroton i ka nui o ka wai a me ka me ka sodium mai ke kino, ʻo ia kekahi o ka hanaʻenehana no ka hoʻohaʻahaʻa i ke koko.

ʻO Lisinopril kekahi o nā mea i ʻike ʻia e hoʻopaʻa ʻia ʻo ACE inhibitors. ʻO kona palapala kikoʻī, ʻo ia hoʻi nā kikoʻī o ka hui carboxyl, e hoʻoholo i kahi hopena lōʻihi loa a ʻoi aku ka maikaʻi i ka hoʻohālikelike ʻia ʻana i nā mea ʻē aʻe o kēia hui.

Wahi a ka annotation, ʻo ka bioavailability o Diroton mai 25-50%, a ʻaʻole pili ka ʻai i ka meaʻai ma kēia uaki. ʻO ka ʻike kiʻekiʻe o ka lisinopril i ka plasma ka mea ma hope o 6 mau hola. Hoʻopuka ʻia ka lāʻau lapaʻau ma nā ʻāpana he ʻelua. ʻO ka mea mua - ma hope o nā hola 12, ʻo ka lua - ma hope o 30 mau hola, i pili i ka manawa o ka pilina me ka angiotensin-hoʻohuli o ka enzyme.

Ma kēia mea e loaʻa ai kahi hopena hypotensive paʻa, lawa ʻo Diroton e lawe i ka manawa 1 i kēlā me kēia lā (ua kuhikuhi ʻia kēia ma nā kuhikuhi i ka lāʻau lapaʻau). Ke kahe mau nei o ka lisinopril ma ke koko e loaʻa ana i ka lā 2 o 3 ka lā o ka lawe ʻana i nā papa, a me ka hopena mau ma ka hopena mau - 2 mau pule ma hope o ka hoʻohana ʻana.

Ua hala ʻo Diroton i ka pale koko-lolo a hiki ke pā i ke kikowaena hanu e kū nei i loko o ka lolo. ʻO ka hopena ʻaoʻao e like me ka wīwī e pili pū me kēia ʻano o ka lāʻau lapaʻau. Eia kekahi, komo ka lisinopril i ke kahe o ka wai plasenta, i mea e pau ai kona hoʻohana ʻana i ka wā hāpai.

Hāʻawi ʻia i ka hoʻohālike o kēia ʻelele o nā inhibitors o ACE me ka diuretics, ua hoʻomohala ʻia ka hoʻomākaukau ʻana Co-Diroton. Ma kahi o lisinopril, aia pū kekahi me ka diuretic sangkap hydrochlorothiazide. Hoʻoikaika kēia mau mea i kēlā me kēia hopena hypotensive o kēlā me kēia.

Wahi a nā kauka, ʻaʻole ka hana liʻiliʻi ma ka hanana nui o Diroton e hoʻokani ʻia ma kāna kumu haʻahaʻa. Hāʻawi kēia iā ʻoe e hana i nā papa lōʻihi o ka lāʻau lapaʻau me ka makaʻu ʻole e hoʻomāʻeha wale i ka mea maʻi ma muli o ka loaʻa ʻole o nā kālā.

ʻO ka lāʻau Diroton ka mea i hoʻokumu ʻia e ka hui Hungarian ʻo GEDEON RICHTER (Gideon Richter). Hoʻonui ʻia ka lāʻau lapaʻau ma ke ʻano o nā papa i loko o kahi waihona o 2.5, 5, 10 a me 20 mg. Hiki i nā blisters ke helu i ka helu, ʻo ka huina o nā pills he 14, 28 a me 56 mau ʻāpana.

ʻO nā ʻōkuhi no ka koho ʻana i nā papa Diroton nā ʻano ala.

• haehae maʻi
• ka huhū puʻuwai hemahema, maʻamau me nā maʻi like ʻole, e hoʻohana ʻia ka lāʻau lapaʻau me ka hui pū me nā lāʻau ʻē aʻe,
• infarction myocardial waha ʻole, me nā ʻōhua hemodynamic paʻa, ka lawe ʻana i nā papa paʻi mai ke kumu ʻo Diroton hoʻomaka i ka lā mua ma hope o kahi hoʻouka ʻana,
• hana ʻino i ka pā kūloko a me ke kiko o ka pūpū (nephropathy) i hoʻokumu ʻia e ka maʻi maʻi.

Hoʻopili ʻia ka hoʻohana ʻana o lisinopril i kēia mau helu:

• ka hele ʻana o kahi hopena alaka i ka lisinopril iho a i nā mea ʻē aʻe o nā papa,
• kekahi mōʻaukala o ka angioedema ma ka mea maʻi ma mua a i ʻole he predisposition hoʻoilina (ʻo ka ʻoi loa ka ʻike a kaulana loa ka inoa ʻo Quincke).
• bilateral renal aren stenosis a i ʻole stenosis kahi o ka hoʻokahi hana hana,
• maʻi pākaha,
• stenosis aortic kino,
• hyperkalemia (pāhaʻi o ka paʻakai ma luna o 5.5 mmol / l).

Me ka mālama akahele, ua kuhikuhi ʻia nā papa kuhikuhi Diroton ma hope o ka hoʻololi ʻana i ka maʻi o ka maʻi, i mua o nā palapala hoʻohālikelike a i ʻole e pae ʻana i ke ʻano o ka hoʻokahe ʻana i ke koko mai ka ventricle hema, leukopenia, anemia. Pono ka nānā ʻana i ke kūlana o ka mea maʻi e pono ai nā maʻi ʻōnaehana o ka kiko hoʻohui.

Pono pono ka nānā ʻana i nā maʻi me ka pilikia ʻole o ka māla. Ma hope o ka kuhikuhi ʻana i nā papa no ke kaomi, ua mālama mau ʻo Diroton i ka pae o ka creatinine a me ka serum potassium potassium. Me ka hoʻohaʻahaʻa ʻana i ka nui o ka filtration glomerular e emi mai ma lalo o 60 ml / min, ua hōʻemi ʻia ka nui o ka lisinopril, ma lalo o 30 ml / min - e ¾.

Me ka iho ʻana i ka hana o ka pēpē, ua paipai ʻia e koho i kekahi inhibitor ACE e hoʻokūkū ana i ka puʻuwai. Pono e hoʻomanaʻo ʻia i hāʻawi ʻia i ka vasodilator a me ka hopena hypotensive o nā papa Diroton, ʻoi aku ka maikaʻi ma ka lā i ke kakahiaka, akā i ke ahiahi, ʻoi loa i ka wā like.

Hiki paha ke ʻano o ka nui o ka lāʻau Diroton ma muli o ka maʻi. No laila, ʻo ka nui mua no ka hypertension pono koʻikoʻi pono he 10 mg i kēlā me kēia lā. Inā hoʻomanawanui maikaʻi ka mea maʻi i ka lisinopril, a laila hoʻonui ʻia i 20 mg. Me ka emi ʻole o ka hopena, ua lawe ʻia ka lāʻau Diroton ma ke 40 mg i kēlā me kēia lā. Eia nō naʻe, ʻoi aku kēia nui o kēia kaieka, ʻo ka mea nui he pōpilikia.

Inā i mālama mua ʻia ka mea maʻi me nā lāʻau lapaʻau ʻē aʻe (ma ka mea maʻamau, diuretics a me nā vasodilator), pono lākou e hoʻokuʻu i nā hola he 24 (ʻoi aku ka lā 2-4 lā ma mua o ka hoʻomaka lisinopril. Inā hiki ʻole kēia no kekahi kumu, ʻaʻole pono ka nui o ka Diroton eʻoi aku ma mua o 5 mg i ka lā.

I kēia hihia, pono e mālama i ka pae o ke kaila o ke koko. ʻO ka manawa pōpilikia loa he 6 mau hola ma hope o ka hopena mua. A laila, ua koho pono ʻia ka paila maikaʻi o ka lisinopril a i ʻole kahi hui kūpono i nā lāʻau lapaʻau.

E like me ka mea i ʻōlelo ʻia ma luna nei, ʻoi aku ka maikaʻi iā Diroton i ke ahiahi. No laila, ke kahe ʻana o ke koko kakahiaka i ka ʻōpala, kahi mea maʻamau no ka maʻi maʻi maʻi.

ʻO ka hoʻohanaʻana i ka lāʻau Diroton no ka hypertension i kumu ʻia e ka disfunction o ka renin-angiotensin-ald testosterone e hoʻomaka me ka liʻiliʻi haʻahaʻa o 2.5-5 mg. Kahi manawa 3 mau lā, e hoʻonui iki ʻia ka 10 mg i kēlā me kēia lā a i ʻole ka ʻanu ʻia. I loko o kēia manawa, nānā ʻia ka hana o ka pēpē, ke koko, a me ke kiʻekiʻe o ka paʻakai a me ka sodium ma ka plasma koko.

Ma kahi hikiʻole i ka puʻuwai, ua lawe ʻia ʻo Diroton me kahi dosis o 2.5 mg, kahi i hoʻonui ʻia ai ka 5-20 mg ma mua o 5 mau lā. Ke koho ʻana i ka nui o ka lā lisinopril i loko o nā mea maʻi me ka nephropathy i ka maʻi mellitus i loko o ke ala like. ʻAʻole iʻoi aku ka nui o ke kahe koko diastolic i kēia hihia ma luna o 85-90 mm Hg.

Ke kuhikuhi nei iā Diroton ma hope o ka myocardial infarction e hōʻike ʻia no nā mea maʻi me ka ʻole o nā hōʻailona o ka hypotension.I ka lā mua a me ka lua o ka lā ma hope o ka hoʻouka ʻana, kuhikuhi ʻia kahi hoʻomākaukau o 5 mg, a laila lawe ʻia ka 10 mg. Lawe ʻia ʻo Lisinopril ma kahi o 6 mau pule. Me ka hoʻohaʻahaʻa ʻana i ke koko, ua hoʻokaʻawale ʻia kēia kaha.

Pono e nānā ʻia he ala kūpono o ka lāʻau lapaʻau Diroton pathologies o ke ʻano cardiovascular ma ka wā kamaliʻi. Wahi a nā kauka, ʻaʻohe i ʻike ʻia nā hoʻokolohua lapaʻau i ka hopena o ka lisinopril ma ke keiki. Ma kēia hana, ʻaʻole i kuhikuhi ʻia ka lāʻau lapaʻau a hiki i ka makahiki 18, ʻoiai no nā kumu olakino.

Ua hoʻohana ʻia ka hoʻohana ʻana i ka lāʻau Diroton i ka wā hāpai. Ka neʻe ʻo Lisinopril i ka papale placental a pili paha i ka hoʻoulu ʻana i ka hypoplasia a me ka hopena ʻole o ke akepaʻa i loko o ka pūpū, ka huinakū ʻana o ka huina, a me ka hoʻōki wai-electrolyte. ʻAʻole kūpono nā ʻano like i kēia me ka hoʻomohala hou.

Inā ua ʻike ʻia ka wā hapai i ka wā o ka mālama ʻana me Diroton, pono e hoʻokuʻu ʻia ka lāʻau ma ka hiki koke, a ma hope o ka hānau ʻana, pono ke nānā pono i ke ʻano o ke keiki. No ka mea, ʻaʻohe data o ka cardiologists ma ke komo ʻana o lisinopril i ka waiū umauma. Eia naʻe, ʻaʻole i aʻo ʻia kona hoʻohana e kūʻē i ka lactation.

ʻO nā hopena ʻaoʻao o ka lāʻau Diroton i loko5-6%nā mea maʻi e hoʻomaopopo:

• lie kanikela
• āhāhuʻe
• maloʻo, lōʻihi ke kau ʻana
• kahi emi o ke kahe koko me ka loli i ke kūlana o ke kino,
• ka walaʻau a ka luaʻi ʻole
• ʻeha ka ʻōpū
• ʻili kino ʻili.

ʻO nā hopena ʻē aʻe e pili pū ana me kahi hopena ma ka hana o aldosterone a līkahi.

Hoʻopiʻi paha nā maʻi i kēia mau ʻōuli:

• ireliaia,
• ka malo maloʻo
• a me nā mea hoʻowalewale ʻole (ka nele o ka makemake, nā hana hoʻokipa, hōʻeha kino),
• hoʻonui hoʻonui ʻia
• mahanahana i ka la,
• ʻO ka luhiluhi, nele i ka nānā, e pono e noʻonoʻo i ka wā e lawe ana i ka kaʻa, etc.
• moena puʻu
• nā maʻi hanu
• kūloko maʻamau
• ka haki ʻana o ka ʻōnaehana hematopoietic (he hāʻule i ka pae o leukocytes, hemoglobin, platelets, neutrophils a me nā mea i hoʻokumu ʻia o ke koko),
• hoʻemi ʻia ʻo ia iho
• nā maʻi urination e pili ana i ka hana renal impaired,
• māhā, hoʻohui ka naʻau, exacerbation of gout.

Me ka ʻike o kēlā mau ʻōloli, ʻaʻole hiki ke hoʻopau koke ʻia ka lāʻau lapaʻau ma muli o ka loaʻa ʻana o ka pilikia i ka nui o ka puʻuwai o ka naʻau.

Ke hoʻokuʻu nei i kēlā me kēia lā o ka hopena ʻo Diroton i ka pōʻino ma o ke kahe nui o ke koko a me ka nānā ʻole. Hoʻopili i nā hōʻailona hōʻailona, ​​lavage lavage a me nā adsorbent, hemodialysis ma kahi "keiki kūlohelohe" e kōkua i ke kāpaeʻana i nā mea ikaika o ka lāʻau lisinopril.

ʻO ka lāʻau Diroton i kahi pae āpau a i ʻole kekahi hopena i nā mea āpau a me nā ʻōnaehana, no laila ʻo ka hoʻokele o nā lāʻau lapaʻau hou e pono ke ʻae me ke kauka. No laila, inā he hana renal impaired i loko o ka mea maʻi, pono nui ka akaʻi ʻana i ka wā e hoʻohui ʻana i ka diuretics pākeleka (Veroshpiron, Aldacton) me ka lisinopril ma muli o ka loaʻa ʻana o ka hyperkalemia.

Hoʻonui nā lāʻau lapaʻau aʻe i ka hopena hypotensive o Diroton:

• mau poloka beta,
• nā antagonis kalona
• hoʻoiho
• kahawai, antidepressants,
• wīwī

ʻO ka hui pūʻana o Diroton me nā mea inu waiʻona e hiki ke alakaʻi i ka hypotension koʻikoʻi.

ʻO ka hana ikaika o ka laʻa Diroton lisinopril e nalo aku nei i kona mau ʻoiai e lawe pū ana me nā lāʻau lapaʻau aʻe:

• ole-anti-lauleia anti-inflammatory,
• Hoʻomākaukau lithium
• nā antacids (e hoʻēmi i ke kao ʻana o ka lisinopril i ka ʻāpana gastrointestinal).

Eia kekahi, pono ka hoʻoponopono ʻana o nā maʻi maʻi hypoglycemic no nā mea maʻi me ka maʻi mellitus.Pono nā wahine e ʻike pono i ka lāʻau Diroton e hōʻemi i ka hopena o ka hopena o ka lāʻau hormonal waha e pale aku ai i ka male ʻana.

ʻAʻole ʻokoʻa loa ka ʻaʻai Hungarian Diroton i nā kumukūʻai.

ʻO ke kumukūʻai o ka hoʻokomo ʻana i nā papa o nā papa he 28 ma ka helu o nā ʻenehana ikaika:

• 2,5 mg - 120 mau rubles,
• 5 mg - 215 rubles,
• 10 mg - 290 mau rubles.

Nā inoa o ka lāʻau Diroton ʻo Lisinopril, Lisinopril Teva, Iramed, Lisinoton, Diropress, Lysigamma, Lizoril, Listril, Liten.

Hōʻike nā hōʻike o nā cardiologists i ka Diroton lāʻau hoʻolako i ka hopena antihypertensive paʻa a me ka pale o nā mea maʻi e hōʻeha nei i ka puʻuwai naʻau. Eia kekahi, ʻo nā mea kūikawā kūikawā o ka lāʻau lapaʻau e ʻae ʻia e hōʻike ʻia no kahi ākea o nā mea maʻi e loaʻa ana i ka hypertension me ka hakakā kūlū me ka hōʻeha o ka ate.

Kūpono ʻia ma ka nūpepa:
"Hypertension System", 2010, Helu 3, p. 46-50

A.A. Abdullaev, Z.Yu. Shahbieva, U.A.Islamova, R.M. Gafurova
ʻO Dagestan State Medical Academy, Makhachkala, Rusia

A.A. Abdullaev, Z. J. Shahbieva, U. A. Islamova, R. M. Gafurova
ʻO ka wahine hoʻokele olakino ʻo Dagestan, Makhachkala, Rusia

Hoʻāla manaʻo
Kumuhana: e hoʻohālikelike i ka holomua, palekana a me ka hoʻonaʻauao pharmaco-ʻekekema o ka mālama ʻana me ka laikini a me ka generic ACE inhibitors lisinopril (Irumed (Belupo) a me Diroton (Gideon Richter) e like me ka monotherapy a me ka hui pū me ka hydrochlorothiazide i nā mea maʻi me ka helu 1-2 arterial hypertension.
Nā pono hana a me nā ʻano: Ua hoʻokomo ʻia nā mea maʻi he 50 me AH o ka 1-2 tbsp ma kahi paʻa no ka hoʻopaʻa ʻia ʻana. (22 kāne a 28 wahine) 35-75 mau makahiki keu, me ka lōʻihi o ka hypertension o 7.1 ± 3.3 mau makahiki. ʻEono mau mea maʻi i haʻalele i ke aʻo ʻana: 2 ma ke kua o ke ʻano maʻi me Irumed a me 4 ma ka ʻaoʻao o ke ʻano me ka Diroton. Ua mālama ʻia ka ʻike ʻana i kēlā me kēia lā i ke koko (BPM) me ka hoʻohana ʻana i nā mea hana SL90207 a me 90202 (SpaceLabsMedical, USA).
Nā hopena: hana me Iramed i alakaʻi i ka nui o ke kahe nui o ke koko (-27.8 ± 8.6 / -15.1 ± 6.9 mm Hg) hoʻohālikelike me Diroton (-21.1 ± 6.9 / -9.0 ± 5.9 mmHg), pHopena: Hōʻike ʻia me ka maʻi ʻĀina i loko o nā poʻe maʻi me ka AH o ka 1-2 koʻikoʻi o ka hopena antihypertensive maikaʻi loa a ʻoi aku ka maikaʻi o ka pharmacoeconomically ma mua o ka Diroton therapy.
Huaʻōlelo kī: hypertension arterial, lisinopril, Irumed, Diroton.

Koi: e hoʻohālikelike i ka hana pono a me ka ʻae ʻana o ka laikini mālama lapaʻau a me ka licin licin Ain inhibitor lisinopril (Irumed, Belupo a me Diroton, Gedeon Richter) i ka monotherapy a me ka hui pū me ka hydrochlorothiazide ma nā mea maʻi me ka hypertension arterial (AH).
Nā pono hana a me nā ʻano: ua wehe ʻia ka hoʻokūkū manuahi noiʻi ʻia he 50 mau mea maʻi me ka AH (22 kāne a me 28 mau wahine he 35-75 mau makahiki) o ka lōʻihi o ka manawa 7.1 ± 3.3 mau makahiki. Ua haʻalele ka mea maʻi 6 i ka noiʻi (Irumed -2 ​​a me Diroton - 4). Ua nānā ʻia ka neʻe koko (BP) no 24 mau hola me ka polokalamu SL 90207 a me 90202 (SpaceLabs Medical, USA).
Nā hopena: ʻOi aku ka nui o ka hōʻemi i ka haukapila o ka BP (-27.8 ± 8.6 / -15.1 ± 6.9 mm Hg) ma mua o Diroton (-21.1 ± 6.9 / -9.0 ± 5.9 mm Hg ), pHopena: Hoʻomaʻamaʻa ka hopena Iruming i ka hopena maikaʻi loa a me ka uku hoʻēmi ma mua o ka lāʻau Diroton i nā maʻi me nā pae 1-2 arterial hypertension.
Huaʻōlelo nui: hypertension arterial, lisinopril, Irumed, Diroton

ʻIkepili e pili ana i nā mea kākau
Abdullaev Aligadzhi Abdullaevich - Kauka med. ʻepekema, poʻo. Ke Keʻena ʻOihana Ola Lapaʻi, Cardiology a me nā Kauka Hoʻolapa Nui
ʻO GOU VPO Dagestan State Medical Academy
ʻO Shakhbieva Zarema Yusupovna - haumāna haumāna o ia keʻena like
ʻO Islamova Ummet Abdulhakimovna - Cand. meli ʻepekema, kōkua i ke ʻano ʻoihana like ʻole. 367030, RD, Makhachkala, I. Shamily Ave., 41, apt. 94.
Gafurova Raziyat Magomedtagirovna - Cand. meli ʻepekema, kōkua i ke ʻano ʻoihana like ʻole. 367010, RD, kulanakauhale o Makhachkala, ul. Mendeleev, d.12.

Hoʻomau
ʻO ka hana maʻi o nā poʻe maʻi me ka arertial hypertension (AH) i kahi hana i kēia manawa, no ka mea e hiki ke hōʻea i ka make cardiovascular (SS) ma kahi o 40%, a me ka lawa kūpono kūpono a me ka palekana, e pili ana ia i nā mea pilikia e hoʻololi ʻia no ka hoʻomohala ʻana i ka maʻi naʻau coronary ( IHD) a me nā maʻi SS ʻē aʻe. Ua hōʻike ʻia nā hopena o nā haʻawina he nui wale ka monotherapy i kahi ʻāpana liʻiliʻi (e pili ana i 30%) o nā mea maʻi me ka hypertension. ʻO ka hoʻohana ʻana i nā lāʻau lapaʻau ʻelua e hiki ai iā ʻoe ke hoʻokō i ka pae o ke kaila o ke koko (Ma hope o ka pau ʻana o ka manawa o ka pale patent, hiki i kekahi hui lāʻau lapaʻau ke hana a kūʻai aku i ka lāʻau lapaʻau. Loaʻa nā pono āpau i ka lāʻau, i hōʻike ʻia i nā hoʻokolohua lapaʻau manuahi manuahi. a me nā lāʻau hana i hana ʻia ma lalo o ka laikini.Pono nā lāʻau lapaʻau e hōʻike i ka hoʻohālikelike i ka hopena i loko o kahi hoʻokolohua lapaʻau i hoʻohālikelike ʻia me ka mea mua. I kēia hihia, hiki iā mākou ke ʻōlelo e like me ka nui o ka lāʻau lapaʻau e ola pono a me ka palekana e like me ka mea maʻamau, a me ka ʻike i loaʻa i ka lāʻau lapaʻau maoli hiki ke hāʻawi ʻia iā ia. ʻO ka mea pōʻino, me kahi helu liʻiliʻi o nā lāʻau lapaʻau, ua hoʻokō ʻia nā noiʻi like like.

I kēia mau makahiki i hala iho nei, ua manaʻo nui ʻia nā kihi waiwai i loko o ka lāʻau lapaʻau. Maʻalo ʻia kēia e ke kālā palena o nā ʻoihana olakino a ma ka hapa nui loa, nā kumuwaiwai waihona o ka mea maʻi iā ia iho. Ke hoʻopau nei i kēia pilikia i ke kūlana i kēia manawa, pono ia e noʻonoʻo pono ʻaʻole i nā hopena lapaʻau a me ka palekana o kahi lāʻau lapaʻau wale nō, akā ʻo ka hopena ʻonaʻāina hoʻi i ka mea maʻi a me ka mālama olakino. Pono e hoʻoponopono i ka pharmacotherapy kūpono ʻole o kekahi maʻi i ka pharmacoeconomics.

ʻO ke kumu noiʻi - hoʻohālikelike i ka hana pono, palekana a me ka hōʻoia o ka pharmacoeconomic o ka mālamaʻana me ka laikini a me ka laikini ACE inhibitors lisinopril (Irumed (Belupo) a me Diroton (Gideon Richter) i ke ʻano o ka monotherapy a me ka hui pū me ka hydrochlorothiazide i nā mea maʻi me ka pae o ka hypertension 1-2 arterial.

Mea hana a me nā ʻano: nā haʻawina i komo ai i nā maʻi he 50 me ka hypertension o 1-2 koʻikoʻi, he 6 nā poʻe maʻi i hoʻokuʻu i ka wā o ka hahai ʻana: 2 i ka wā e mālama pū ai me Irumed a me 4 i ka wā mālama me Diroton. Loaʻa kahi 44 o nā mea maʻi i hoʻopau i ka noiʻi I ka mua, ʻaʻole i like nā hui i nā ʻokoʻa i ka wā o ka makahiki, nā kāne, a me nā ʻano ʻē aʻe (Papa Papa 1). Ke komo pū nei ka haʻawina i nā maʻi 18-75 mau makahiki me ke maʻi hypertension hou a i ʻole mau i lawe i ka lāʻau antihypertensive i loko o ka mahina i hala. I ka manawa hoʻokomo, ʻo ka hui o ka hui o ka systolic blood pressure (SBP) ma ke kūkaʻi (papa) he 158.5 ± 7.5 mm Hg. Art., Ke dihe koko diastolic (DBP) C. 97.5 ± 5.0 mmHg. Art., Puʻuwai puʻu 74.7 ± 8.8 mau kui / min. ʻO nā kumu o ka wehe ʻana: nā puka pae lua o ke hypertension, ʻo ka ulia o ka cerebrovascular ulia, ka hala o ka myocardial infarction i nā mahina 6 hope loa, ka angina pectoris II-III FC, ka puʻuwai puʻuwai, ka arrhythmias cardiac, nā ate a me ka hana.

Papa 1. ʻO ke ʻano lapaʻau mua a me ka demographic a me nā hiʻohiʻona o nā hui

Hoʻolālā: ka hana noiʻi manuahi, wehe ʻia i mua, koho, a hana ʻia e like me nā kānāwai GCP (Maikaʻi Kino Hana Kūleʻa) a me ka 2000 Helsinki hoʻolaha. ʻO ka lōʻihi o ka nānā ʻana he 24-25 mau pule. Ma mua o ke komo ʻana i ka noiʻi ʻana, ua hōʻiliʻili ʻia ka mōʻaukala olakino holoʻokoʻa i nā maʻi āpau, ua hoʻokō ʻia kahi hōʻike kino, ʻike ʻia ke koko e ke ʻano ʻo Korotkov, a ma hope e ʻike i nā mea maʻi i ʻike ai i nā paʻa o ke komo ʻana a ʻaʻole i loaʻa nā laʻa i hoʻohiki paʻa ʻia i nā hui like like, ʻo ka mea mua i hoʻomaka i ka mālama ʻana me Iramed a me ka lua me Diroton ma kahi kūpono o 10 mg / lā. Ma hope o 2 mau pule, i ka loaʻa ʻole i ka pae o ka pae koko o ka nui (ua hoʻākāka ʻia ke koko o ke olakino e like me ka awelika o 3 mau ana o ke kao o ke koko me ka sphygmomanometer manual ma kahi kūlana e noho ana ma hope o nā minuke 10-15 o ka hoʻomaha, a kū pū nō hoʻi, 1 mau minuke ma mua o ka lawe ʻana i ka lāʻau lapaʻau i ka lā o ka kipa. no nā koina koko AD, lawe lākou i ka hōʻemi ma nā pūʻulu DBP ma o 10% ko 10 mm mau mau Hg a me nā huaʻelima GARDEN e 15 mm Hg mai ka pae mua. hōʻano uila papahana ʻo Statistiсa 6.0 (Statsof t, USA) hoʻolako ʻia no ka hiki ʻana o ka parametric a me ke ʻano nonparametric.ʻO ka manaʻo i manaʻo ʻia he mea nui i ka pNā hopena a me nā kūkākūkā

ʻO nā lāʻau ʻelua i hoʻopaʻa ʻia me ka hopena antihypertensive maikaʻi, i hoʻonui ʻia e ka neʻe ʻana o nā mea maʻi e hui pū ai i ka maʻi. Hōʻike nui ʻia i ke kahe koko nui e like me ka cl. HELL, a e like me ka Smad. Ma hope o 2 mau pule o ka lisinopril ma kahi o 10 mg / lā i loko o ka hui Irumed, hōʻemi ke koko i ka 158.4 ± 7.4 / 98.2 ± 4.4 mm Hg. ʻAniā. a hiki i 146.1 ± 9.1 / 93.1 ± 6.1 mmHg. ʻAniā. (pPalapala 2. Nā kumukanawai o ke koko. i ka wā o ka mālama ʻana me Irumed a me Diroton.

ʻOi aku ka maikaʻi o lisinopril a i ka diroton? Poke? I? O man?

Mākaukau e pili ana i ka Lisinopril Lisinopril, ATX code ATC C09AA03 E hālāwai pinepine me nā puka hoʻokuʻu no nā mea he 100 ʻoi i loko o nā hale kūʻai kūʻai ma Moscow, ʻo Diroton Diroton.

Kokoke like kēia like. Aia nā contraindications (he nui). E ʻōlelo me kekahi kauka ma mua o ka lawe ʻana.
ʻO nā ʻokoʻa nui he contraindications, no ka mea ua pāpā ʻia ʻo Diroton no ka poʻe maʻi me ka edema mehana ʻo Quincke, a me Lisinopril no ka poʻe maʻi maʻi intolerant lactose, me ka hapa o ka lactose, a me ka malabsorption glucose-galactose hoʻi.

He mau lāʻau lapaʻau like maoli kēia.
ʻO Diroton kekahi o nā inoa kālepa no ka lisinopril
Ka ʻokoʻa wale ka ʻokoʻa i ka mea hana a me ka uku

Kōkua kēlā. He hana like ʻole nā ​​lāʻau lapaʻau ma luna o nā mea āpau

ʻO nā huaʻōlelo nui a ka maʻi hypertension, lisinopril, Irumed, Diroton.If monotherapy me lisinopril Irumed a ʻaʻole i ʻae ʻia ʻo Diroton e hiki aku ai i ka pehu koko o ka hopena, a laila ma hope o 2 mau pule, ua hoʻohui ʻia ka hydrochlorothiazide hydrochlorothiazide GCT he 12.5 mg i hoʻokahi lā me ka hui pū ʻana.

ʻAʻole wau i hoʻokomo kūpono i kēlā a me kēia mea'ē aʻe ... ʻaʻohe hopena

ʻO ke kumu o ka laikini ʻo lisinopril dihydrate, a ʻo ka ʻokoʻa i nā mea hou aʻe, ʻo ia ka inoa me ka helu mua ma Latin Teva, Actavis, Ratiopharm, Stada, a me kekahi pūʻulu o nā ʻano kaawale o ka hoʻokuʻu ʻana i ka Indapamide, Diroton, Irumed, Dapril, Captopril, Sinopril ...

ʻAe, ua pupule paha ʻoe. E lawe i ka hoʻohālike i kā mākou aspirin, a me ka aspirin mai USA a hoʻokahi a he like ia, a he ʻokoʻa ka hopena. Hana wau i loko o ke kīhāpai, no laila ua kamaʻāina wau i ke kūlana

Kaukuhi ʻo Diroton lisinopril Producer Richter Gedeon Ltd, ʻo Hongikona. ʻO wai ka mea i hōʻike ʻia ʻo Diroton. Hypertension arterial i loko o ke ʻano o monotherapy a i hui pū me nā lawena antihypertensive.

Kūpono kēlā. Holoi mākou i loko o ke kupuna.
Kūʻai mākou no ka hoʻolaha, no ka hoʻopiha paʻa.

Manaʻo wau e, i kēia ka poʻe maʻa mau o ka poʻe Kina, ua hoʻohana lākou i ka lāʻau lapaʻau kuʻuna no nā makahiki he mau makahiki, ʻaʻole naʻe lākou e hoʻokuʻu iā lākou !!

E nānā pono. Aia ʻekolu ʻaoʻao o ka paʻakai: ka papaʻaina, ke kai, a me ka ʻenehana. ʻO Fomula kahi mea sodium klorida. Akā ʻokoʻa ka haumia ... e ninini ana i ka paʻakai ʻenehana i loko o kāu pāʻai? Pēlā nō i nā lāʻau lapaʻau. ʻoi aku ka hau o ka hana. No ka mea, he ʻoi aku i ka mana hoʻokūkū.

Aia kekahi lāʻau lapaʻau. Loaʻa ʻo Duphaston e pili ana i 500 rubles, aia kahi Lūkini Lūkini (poina inoa) -120 mau rubles. - ʻaʻohe ʻokoʻa. Akā i ka manawa like, ʻaʻole kōkua kā mākou acyclovir, ʻoiai ke kumukūʻai o kekahi penikala, a kōkua koke ʻole ʻo ia ka impartial-170p.

ʻAʻole wau e ʻōlelo ʻaʻole e kōkua ka acyclovir, akā aia nā ʻokoʻa i ka ʻokoʻa o hoʻokahi maʻi, ua kōkua ʻo ia i kekahi manawa, a me kekahi ʻaʻole pololei.
Akā! ʻOluʻolu wau he diroton (import), hoʻololi i kā mākou lisinopril (ʻo ka lisinopril ka mea ikaika e hana nei, ʻae hoʻokahi) -effect 0. Aia kahi ʻokoʻa, ʻoiai he 30% ka hopena i makemake ʻia e hoʻōla i ka home ma mua o ka hoʻokomo

A ʻoi aku ka maikaʻi diroton a i ʻole ka prestarium, ʻo ka mea ʻokoʻa ma waena o nā lāʻau lapaʻau .. ʻO Diroton lisinopril kekahi o nā mea paʻa o ka ACE. ʻO ka Prestarium perindopril kekahi lāʻau lapaʻau mai ka hui like.

Hiki iā wau ke haʻi i ka waika Acetylsalicylic o kā mākou hana a me Bayer (ʻaʻole wau ʻike e pili ana i ka USA): ka ʻāmaku he racemate (hui) o 2- (Acetyloxy) ka waikiko benzoic a me 4- (Acetyloxy) benzoic acid, a ua hoʻopiha ka mea Kelemania iā 4- (Acetyloxy ) ʻōpiopio benzoic, a no laila eʻoi aku ka maikaʻi. (No laila ua haʻi mai iaʻu ke kauka lāʻau lapaʻau i nā mea ʻepekema kula).
A laila aia he mau lāʻau loea Generic a me nā mea mua (Generic paha loaʻa nā koho ʻē aʻe ma mua o ka mea maoli - a me nā mea āpau āpau ke loaʻa nā mea hoʻonani i loko o ka nui e pili ana i ka hana o nā lāʻau lapaʻau lāʻau (hōʻemi i ka wae ʻana (hoʻonui / hoʻemi), a me nā mea ʻē aʻe)
ʻO ka lāʻau lapaʻau kumu mua: hoʻomohala ʻia, e lawaiʻa i nā noiʻi a pau, me ka make ... (he uku kālā ke ....) a hoʻohua ʻia ka generic ma hope o ka pau ʻana o ka mana o ka ʻenekine a i ʻole a ma kahi o ke hoʻololi ʻana iā Aux.
No laila, ua hula mākou, ʻoi aku ka maikaʻi….

Pono kahi kūleʻa kālā. Na wai e uku no ia inā ʻaʻole mākou?

I kēia ke koi ʻana, pono ʻoe e kāhea i kahi ambulance, inā ʻole hiki iā ʻoe ke neʻe i ka lio

Nā kuhikuhi o nā papa Diroton. Nā papa kuhikuhi Diroton ʻO ka helu helu balota 8. ʻO ka mea hana ʻo Gideon Richter Hoʻolaha pepa e loaʻa nā mea hou aku o nā papa Diroton. Nā papa Lisinopril ʻOi aku ka helu o nā balota 18. ʻO ka analogue ka mea liʻiliʻi loa mai ka 60 mau rubles.

E hoʻāʻo a LYSINOPRIL 10 a 20 paha inā ʻaʻole ʻoe e lawe 10. E inu i 1 papa i ka pō.

No laila pono ʻoe e haʻi i ke kauka a koho i nā mea hou aʻe, me ka mea pono e inu i ka diuretics

ʻO Ambulance, e hāʻawi lākou i nā injections. Pono ka wikiwiki e hōʻoluʻolu i ka neʻe ʻana, no laila, ʻaʻole pono nā hanana ponoʻī iā ʻoe iho.

ʻO ka ʻaoʻao koʻikoʻi o Diroton ka lisinopril ʻO ke kumukūʻai o Diroton 20 mg he 600 rubles. ʻO nā analogues o Diroton kūpono me ka lisinopril kumu nui.

ʻO ke kīpē i paʻu ʻia i ka captopress (kapoten) - 1 papa a ma lalo o ka alelo (e hoʻomāloo koke ʻia ia a hana ʻia. A ma hope o 30 mau minuke ke ana ʻia - a hilinaʻi ma kēlā me kēia - papa ʻē aʻe. Akā, ʻo kēia lāʻau lapaʻau ka kūpono wale nō no nā pōpoki, ʻaʻole kūpono ia no ka lāʻau, no laila he pokole ia aole oia e paa i ka hooikaika ana no ka manawa loihi.
Inā ʻoe i hoʻohālikelike ʻia i nā lāʻau lapaʻau, a laila e loiloi ʻia ko lākou hopena ma hope o 2 mau pule wale nō, a i ka nui - ma hope o 4 hebedoma. No laila e holo wikiwiki i nā manaʻo.

I ke kauka, a inā ʻaʻole kōkua aku nā penikala, a laila pono ʻoe e hoʻāʻo i nā poʻe ʻē aʻe. hana nā kānaka āpau!

ʻOooooh a pehea paha ʻoe iho! I ka hiki ke kūpaʻa pinepine ʻia ma lalo o ka lehelehe, volidol a i ʻole nitroglycerin ma lalo o ka alelo a me ke kelepona ʻana iā ia he ambulance !! ! Pono ʻoe e kau ʻia ma loko o ke keʻena therapeutic a i ʻole ma ke ʻano cardiology! ʻAʻole naʻe i kēia manawa i ka maʻamau !! ! Maopopo wau inā he wahine makua !! ! Akā ʻaʻole i kēlā makahiki

I kēia neʻe nui, pono ʻoe e hoʻoili i ka dibazole me ka papaverine (he halepule kēia)

Ёёёёё….
ʻO ka Diroton helu 10, hiki iā ʻoe ke helu 5
i nā pilikia pilikia, e hana nā ʻauʻau lima wela ma ka pulima, ʻaʻole iʻoi aku ma mua o 5 mau minuke - e hoʻonui wikiwiki nā moku, e emi ana ke kaumaha a hele ka huakaʻi ...
Ua nānā ʻia ʻoe? pono ʻoe e ʻike i ka pilikia o ka pilikia.

ʻAʻole kuhikuhi ʻo Diroton i ka lisinopril. ʻO Gideon Richter ka mea nāna e hana, he mea kanu ʻo ia ma Hungary, kahi lākou e lawe ai i ka waiwai aʻu i ʻike ʻole ai.Kanuʻu loa wau i ka mea i manaʻo ʻia ʻo Mikhail Yuryevich e hiki ke hūnā i hoʻokahi a ʻelua mau atom wai e hūnā i kahiʻokoʻa nui!

Palapala hoʻohālikelike a me nā kumukūʻai

Diroton (Lisinopril) - ʻōlelo aʻoaʻo no ka hoʻohana (abstract)

He palapala a ka mea kākau o ke kahua, he kanaka lapaʻau, ma ka mālama ʻana o ka maʻi hypertension

ʻO nā pili āpau āpau

Aia kekahi mau contraindications. E ʻōlelo me kekahi kauka ma mua o ka lawe ʻana.

Nā inoa kūʻai aku ma waho (ma waho) - Acebitor, Acemin, Acerbon, Acinopril, Carace, Cipril, Coric, Diotril, Hipril, Lanatin, Linoxal, Lipril, Lisihexal, Lisinostad, Lisitec, Lisodura, Lisotec, Nivant, Novatecos, Odace, , Prinivil, Ranopril, Renotens, Secubar, Sedotensil, Sinopren, Tensiphar, Tensopril, Tevalis, Tobicor, Trupril, Vivatec, Zestomax, Zestril.

Aia kekahi ʻanakui ACE ʻē aʻe.

Aia nā lāʻau āpau i hoʻohana i ka cardiology ma aneʻi.

Hiki iā ʻoe ke nīnau i kahi nīnau a waiho paha i kahi loiloi e pili ana i ka lāʻau lapaʻau (eʻoluʻolu e poina e haʻi i ka inoa o ka lāʻau i loko o ka memo leka uila) ma aneʻi

Hoʻomoe a loaʻa ka lisinopril (Lisinopril, ATX code (ATC) C09AA03):

Iʻoi aku ka maikaʻi o ka generic?

Nā lāʻau lapaʻau a me ka lāʻau lapaʻau:

ACE Inhibitor (Angiotensin Convertting Enzyme)

ʻO ka pale o ACE, e hōʻemi i ka hoʻokumu ʻana o ka angiotensin II mai angiotensin I. ʻO kahi hoʻoneʻe i loko o nā kiko o ka angiotensin II e alakaʻi i kahi lae i ka hoʻokuʻu ʻana o ka aldosterone. Hoʻemi i ka hōʻemi o ka bradykinin a hoʻonui i ke ʻano o ka prostaglandins. Hoʻemi ia i ka OPSS, ke koko, preload, kaomi i ka pulillary pulmonary, e hōʻemi i ka nui o ke kaila o ke koko a hoʻonui ʻia i ka hoʻokuu myocardial i ke kaumaha i loko o nā poʻe maʻi me ka hoʻopiʻeha o ka naʻau. E hoʻonui i nā arela i ka nui aʻe o nā veins. Ua wehewehe ʻia kekahi mau hopena e ka hopena ma ka ʻimi renin-angiotensin. Me ka hoʻohana ʻana i ka lōʻihi, ua emi nā hypertrophy o ka myocardium a me nā paia o nā ʻāpana o ke ʻano o ka mea pale. Hoʻomaikaʻi i ka hāʻawi ʻana i ke koko i ka myocardium ischemic.

Hoʻonui ʻo ACE inhibitors ola i ka manaʻolana i ka poʻe maʻi me ka puʻuwai puʻuwai, e lohi i ka holomua o ka hōʻolo ʻana o ka ventricular hema i loko o nā mea maʻi ma hope o ka myocardial infarction me ka hōʻike ʻole ʻana i nā kauka o ka puʻuwai ʻole.

ʻO ka hoʻomaka ʻana o ka lāʻau - ma hope o ka hola 1, hiki i ka lōʻihi ma hope o nā hola 6-7 a lōʻihi i nā hola 24. ʻO ke lōʻihi hoʻi o ka hopena e hilinaʻi ʻia ana i ka nui o ka hopena i lawe ʻia. Me ka hypertension arterial, ua hōʻike ʻia ka hopena i nā lā mua ma hope o ka hoʻomaka ʻana o ka mālama ʻana, hoʻomohala kahi hopena ma hope o 1-2 mau mahina. Me kahi hana hoʻihoʻi i ka lāʻau lapaʻau, ʻaʻohe mea i ʻike ʻia ka nui o ke kahe koko.

Hoʻemi ka Diroton® i ka albuminuria. I ka poʻe maʻi me ka hyperglycemia, kōkua ia i ka hoʻohālikelike i nā hana o ka endothelium glomerular iʻino. ʻAʻole pili i ka luhi o ke kaila koko i loko o nā poʻe maʻi me ka maʻi mellitus a ʻaʻole i alakaʻi i ka hoʻonui ʻana i nā hihia o ka hypoglycemia.

Ma hope o ka lawe ʻana i ka lisinopril i loko, ua hōʻea ʻo Cmax ma hope o nā hola 7. ʻO ka awelika o ka absorption o lisinopril ma kahi o 25%, me ka nui o ka interindividual variability (600060%). ʻAʻole ʻai i ka ʻai i ka hoʻopili ʻana o ka lisinopril.

Hoʻopili maikaʻi ʻo Lisinopril i nā protein plasma. Hōʻike ʻia ka mana holoʻokoʻa ma o BBB a me ka loaʻaʻana o ka placental.

Laminopril ʻaʻole metabolized.

Hoʻopili wale ʻia ia e nā keiki i loli ʻole. Ma hope o ka hoʻokele ʻana, ʻo ka T1 / 2 pono ka 12 hola.

I nā poʻe maʻi me ka paʻa ʻole o ka naʻau, ua hoʻemi ʻia ka ʻili ʻana a me ka hoʻomaʻa i ka lisinopril.

Hola i ka hana renalaries i alakaʻi i ka hoʻonui i AUC a me T1 / 2 o lisinopril, akā ke lilo nei kēia mau hoʻololi i ka nui inā paha i ka wā o ka glomerular filtration rate ma mua o 30 ml / min.

I nā poʻe maʻi ʻelemakule, ʻo ka neʻe o ka lāʻau i loko o ka plasma a me AUC he 2 mau manawa kiʻekiʻe ma mua o nā maʻi ʻōpio.

Hoʻopau ʻia ʻo Lisinopril e ka hemodialysis.

Ka hoʻoponopono ʻia ʻana

Lawe ʻia ka lāʻau make i ka manawa 1 i kēlā me kēia lā, no nā hōʻailona āpau, me ka pili ʻana o ka meaʻai, makemake ʻia i ka manawa like o ka lā.

Me nā hypertension koʻikoʻi, ʻaʻole nā ​​mea maʻi e loaʻa ana nā lāʻau antihypertensive e like me 10 mg i hoʻokahi i kēlā lā. ʻO ka dosis lapaʻau maʻamau maʻamau i kēlā me kēia lā he 20 mg. ʻO ka pae ʻauʻau nui loa ʻo kēlā me kēia lā he 40 mg.

Hoʻohālikelike ka hopena piha ma hope o nā hebedoma ʻo 2 mai ka hoʻomaka ʻana o ka mālama ʻana, pono e lawe ʻia i ka wā e hoʻonui ana i ka ʻai. Me ka hopena ʻole o ka lāʻau lapaʻau, hiki ke hoʻohui i ka lāʻau lapaʻau me nā lāʻau lapaʻau antihypertensive ʻē aʻe.

Inā loaʻa i ka mea maʻi ka hoʻomaʻamaila mua me ka diuretics, a laila hiki ke hoʻokipa ʻia kā lākou hoʻokipa i ka lā 2-3 ma mua o ka hoʻomaka ʻana o ka hoʻohana ʻana iā Diroton. Inā hiki ʻole ke kāpae i ka diuretics, a laila ʻaʻole pono ka lāʻau mua o Diroton eʻoi aku ma mua o 5 mg i kēlā me kēia lā. Ma kēia hihia, ma hope o ka lawe ʻana i ka maʻi mua, ua mālama ʻia ka nānā ʻana i nā mea lapaʻau no kekahi mau hola (ʻo ka hopena ʻoi loa ka hopena ma hope o ka 6 mau hola), no ka mea hiki i kahi emi o ke kō koko ke ulu.

I ka hihia o ka renovascular hypertension a i ʻole nā ​​kūlana ʻē aʻe me ka hoʻonui ʻana i ka hana RAAS, ʻoi ʻia hoʻi e kuhikuhi i kahi helu haʻahaʻa haʻahaʻa o 2.5-5 mg i kēlā me kēia lā ma lalo o ka hoʻomohala ʻana i ke olakino (e hoʻolilo i ke koko, hana o ka hana, ka paʻū o ka serum potassium). Pono e hoʻoholo ʻia ka mālama mālama ʻia e pili ana i ka dinamics o ke koko.

Ma ka renal ka maikaʻi ʻana, ma muli o ka lisinopril ua hoʻopili ʻia e nā ʻōpū, pono ke hoʻoholo ʻia ka ʻōlelo mua ma muli o ke kaʻe ʻana o KK, a laila, e like me ke ʻano o ka hopena, pono ke kūkulu ʻia kahi mālama mālama ma lalo o nā kūlana o ka mālama pinepine ʻana i ka hana o ka renal, ke kāʻei o ka paʻakai a me ka sodium i loko o ka serum.

Ma kahi hana pohihihi, hiki ke hoʻonui ʻia ka nui o ka maʻi ma mua o 2,5 mg 1 mau manawa i kēlā me kēia lā, hiki ke hoʻonui iki i 3-5 mau lā i ka mea maʻamau, e kākoʻo ana i ka helu i kēlā me kēia lā o 5-20 mg. ʻAʻole pono ʻo ka pona ma mua o ka nui o kēlā me kēia lā o 20 mg. Me ka hoʻohana like ʻana me ka diuretics, pono ke hoʻohaʻahaʻa ʻia ka nui o ka diuretic ma mua, inā hiki. Ma mua o ka hoʻomaka ʻana i ka mālama ʻana me Diroton® a ma hope iho, i ka wā o ka mālama ʻana, ke kahe o ke koko, ka hana ʻana o ka maʻi, ka paʻakai a me ka sodium i loko o ke koko e nānā mau ʻia e pale aku i ka hoʻomohala ʻana o ka hypotension arterial a me ka hana o ka maʻi pili.

In myocardial infarction (ma ke ʻano o ka hoʻohui ʻana i ke ʻano lāʻau), 5 mg e kuhikuhi ʻia i ka lā mua, 5 mg ma ka lua o ka lā, 10 mg ma ke kolu o ka lā, a me kahi mālama mālama o 10 mg hoʻokahi i ka lā. I nā maʻi me ka maʻi myocardial infarction, pono ke hoʻohana ʻia ka lāʻau lapaʻau no ka liʻiliʻi loa he 6 mau hebedoma. Me ka haʻahaʻa koko systolic haʻahaʻa (emi iho ma lalo o 120 mm Hg. Art.), Hoʻomaka ka mālama maʻi me kahi haʻahaʻa haʻahaʻa (2.5 mg /). I ka hihia o ka hoʻomohalaʻana o ka hypotension arterial, i ka nui o ke kaomi koko systolic e emi mai ma mua o 100 mm Hg. Art., Hoʻemi ʻia ka nui o ka mālama ʻana i 5 mg i kēlā me kēia lā, inā pono, hiki iā ʻoe ke koho iki i ka 2.5 mg i ka lā. Ma ka hihia o kahi hoʻohaʻahaʻa lōʻihi i hoʻokahe nui i ke koko (systolic blood pressure ma lalo o 90 mm Hg. Art. ʻOi aku ma mua o ka 1 hola), pono ia e hooki i ka mālama ʻana me ka lāʻau lapaʻau.

I loko o ka nephropathy maʻi maʻi i nā maʻi me ka mellitus diabetes i hilinaʻi ʻia, hoʻohana ʻia ʻo Diroton® ma ke ʻano o ka 10 mg hoʻokahi i ka lā.Inā pono, hiki ke hoʻonui ʻia i kēia maʻa i 20 mg hoʻokahi i ka lā i ka mea e hoʻokō ai i nā hoʻololi koko diastolic ma lalo o 75 mm Hg. ʻAniā. i kahi noho. I ka poʻe maʻi me ka diabetes-mellitus non-insulin-kumu, i kuhikuhi ʻia ka lāʻau lapaʻau i loko o ka hopena like, e hiki ai ke hoʻokō i nā koina koko diastolic ma lalo o 90 mm Hg. i kahi noho.

ʻO ka hopena maʻamau ka hopena o ka dizziness, headache (5-6%), nāwaliwali, ke nānā ʻana, ka wai maloʻo (3%), ka luaʻi, ka luaʻi, ka orthostatic hypotension, rash skin, heart pain (1-3%).

ʻO ka lōʻihi o nā hopena kū'ē'ē aʻe ma mua o 1%.

Mai ka pūnaehana cardiovascular: ka hōʻailona hōʻemi i ke kahe o ke koko, ka ʻeha ʻeha, ka liʻiliʻi - hypotension orthostatic, tachycardia, bradycardia, ka helehelena o nā hōʻailona o ka pohihihi o ka naʻau, ka hoʻopiʻi ʻana o AV, ka myocardial infarction.

Mai ka pūnaehana ʻana: ka mualea, ka luaʻi, ka ʻōpū o ka ʻōpū, ka malo maloʻo loa, nā maʻi ʻeha, ka dyspepsia, anorexia, ʻōpū ʻono, ʻōpū, ʻeliʻoki, hepatitis (hepatocellular a me cholestatic), ka maʻi āpau (hepatocellular a cholestatic), hyperbilirubinemia.

Ma ka ʻāpana o ka ʻili: urticaria, hoʻonui nui ʻana, photosensitivity, ʻeha, hōʻiliʻili lauoho.

Mai ka ʻaoʻao o ka pūnaehana nīnū o ka pokela: ka hana o ka hanu, paʻa i ka hopohopo, paresthesia, nui ka momona, ka hiamoe, hoʻomāhaʻaka ʻo nā hoilo o nā ʻāʻī o nā limahana a me nā lehelehe, ʻaʻole ka maʻi - asthenic syndrome, plue.

Mai ka pūnaehana hanu: dyspnea, kōloʻo maloʻo, bronchospasm, apnea.

Mai ka pūnaehana hemopoietic: leukopenia, thrombocytopenia, neutropenia, agranulocytosis, anemia (kahi hoʻoliʻoli ʻana o ka hemoglobin, hematocrit, erythrocytopenia), me ka mālama mau loa, he hōʻemi hoʻemi i ka hemoglobin a me ka hematocrit hiki, i kekahi mau kūlana - agranulocytosis.

Nā hui kūloko: angioedema o ke alo, nā wāwae, nā lehelehe, ka huaʻōlelo, ka epiglottis a me / a i ʻole larynx, kaʻōpōlani ʻōpula, vasculitis, mau hopena kūpono i nā antibodies antinuclear, hoʻonui i ka ESR, eosinophilia, i nā hihia lola - interstitial angioedema (pulmonary edema me ke interstitial tissue puka o ka transudate i loko o ka lumen o ke alveoli).

Mai ka pūnaehana genitourinary: uremia, oliguria, anuria, functioning renal impaired, kaulike ʻole o ka pale renal, i hōʻemi ʻia ka potency.

Nā hōʻailona labana: hyperkalemia a / a i ʻole hypokalemia, hyponatremia, hypomagnesemia, hypochloremia, hypercalcemia, hyperuricemia, hoʻonui i ka urea plasma a me ka hana ʻana, hypercholesterolemia, hypertriglyceridemia, hoʻemi i ka hoʻohaʻahaʻa glucose.

ʻO nā mea'ē aʻe: arthralgia, arthritis, myalgia, fever, exacerbation of gout.

Me ka makaʻala, pono ke ʻano o ka lāʻau lapaʻau no ka stenosis renalal renal o ka stenosis a i ʻole ka stenosis o ke aʻa o ke keiki hoʻokahi, ka maʻi ma hope o ka hoʻololi ʻana i ka huehue, ka pilikia ʻole (CC ma mua o 30 ml / min), stenosis o ka orifice aortic, hypertrophic obstract cardiomyopathy, primer hyperaldosteronism, hypotension arterial, cerebrovascular komo pū me ka cerebrovascular insufficiency), maʻi maʻi coronary, ʻano ʻano nui o ke ʻano maʻi mellitus, hōʻeha puʻuwai paʻakikī, nā maʻi ʻōnaehana kao (me ka scleroderma, systemic lupus erythematosus), inhibition of bone marve hematopoiesis, hypovolemic kaayaan (me ke ʻano o ka maʻi ʻaʻai, ka luaʻi), hyponatremia (i nā mea maʻi ma ka liʻiliʻi-paʻakai a i ʻole ka paʻakai paʻakai, ua nui ka hopena o ka ulu ʻana i ka lāʻau hypotension), nā mea maʻi maʻi me nā hemodialysis e hoʻohana ana i nā membraes dialy-kiʻekiʻe (AN69®).

Hoʻopili ka hoʻohana ʻana o Diroton i ka wā hāpai. Hiki ʻo Lisinopril i ke kālai placental. Ke paʻa nei ka hapai, pono e hoʻokuʻu ʻia ka lāʻau i ka hiki. ʻO ka ʻae ʻana o nā mea paʻa o ka ACE ma II a me III trimesters o ka hapai i loaʻa ka hopena maikaʻi loa i ka ʻōpio (kahi i hoʻohaʻaha ʻia ka nui o ke koko, ka hiki ʻana o ka pilikia, hyperkalemia, hypoplasia cranial, hiki i ka make intrauterine).ʻAʻohe ʻikepili i ka hopena maikaʻi o ka lāʻau lapaʻau ma ka fetus inā hoʻohana ʻia ma ka trimester mua. No nā pēpē a me nā pēpē e hana nei i ka ʻike intrauterine i ka pale ʻana i ka ACE, e hāmama ʻia e mālama pono i ka nānā ʻana i ka manawa kūpono e ʻike ai i kahi emi o ke koko, oliguria, hyperkalemia.

ʻAʻohe ʻikepili i ka pā ʻana o ka lisinopril i ka waiū umauma. Inā kūpono, ʻo ke koho ʻana o ka lāʻau i ka wā lactation, ʻo ka hōʻuluʻulu ʻana o ka waʻa e hoʻopau ʻia.

I ka hihia o ka renal ka hopena, ma muli o ka lisinopril e hoʻopili ʻia ma o nā ʻōpū, pono e hoʻoholo ʻia ka ʻōlelo mua ma muli o ka cleince cleinine, a laila e like me ka hopena, pono e kūkulu ʻia kahi hana mālama ma lalo o nā kūlana o ka nānā pinepine ʻana i ka hana renal, potassium a me ka sodium concentration i loko o ka serum koko.

Me ka makaʻala, pono ke kuhikuhi ʻia ka lāʻau lapaʻau no ka hoʻopiha ʻana i ka pilikia o ka pilikia, bilateral renal aren stenosis a i ʻole ke ala o ka stenosis o ke keiki hoʻokahi me ka azotemia holomua, ke ʻano ma hope o ka hoʻohuli ʻana i ka maʻi, renal failed, azotemia.

ʻO ka pinepine, ʻo ka hoʻohaʻahaʻa pane ʻana i ke kahe o ke koko e loaʻa me ka hoʻohaʻahaʻa ʻana i ka nui o ka wai i hoʻihoʻi ʻia e ka diuretic therapy, kahi hōʻemi ʻana i ka paʻakai i ka meaʻai, ka dialysis, ʻōpū, a i ʻole ka luaʻi. I ka hiki ʻana o nā puʻuwai pale me ka hiki ʻole o ka renal a i ʻole ʻole me ka mea, hiki ke hōʻemi ʻia kahi hōʻailona o ke koko. Hōʻike ʻia ka emi ʻana o ke kahe o ke koko i loko o nā mea maʻi me kahi ʻeha o ka puʻuwai o ka puʻuwai, ma muli o ka hoʻohana ʻana o ka diuretics i nā kuleana kiʻekiʻe, hyponatremia, a i ʻole hana i ʻole ke kauā. I kēlā mau mea maʻi, pono e hoʻomaka ʻia ka mālama ʻana me Diroton ma lalo o ka mākaʻikaʻi koʻikoʻi o kekahi kauka (me ka makaʻala, koho i kahi ʻano o ka lāʻau a me ka diuretics).

Pono e mālama ʻia nā lula like ʻole i ka kuhikuhi ʻana iā Diroton i nā mea maʻi me ka maʻi ʻalopona coronary, hiki ʻole i ka cerebrovascular, ma ke ʻano o ka hōʻemi o ke koko e hiki ai i ka infoction myocardial a stroke.

ʻO kahi pane transit hypotensive ʻaʻole ia he contraindication no ka lawe ʻana i ka hopena hou o ka lāʻau.

Ma mua o ka hoʻomaka ʻana i ka mālama ʻana me Diroton, inā hiki, e hoʻokaʻawale i ka hoʻohuihua a me / a i ʻole no ka pau ʻana o ka wai o ka wai, mālama pono i ka hopena o ka hopena mua o Diroton ma ke koko o ka mea maʻi.

ʻO ka mālama ʻana i ka hypotension araticial symptomatic kahi o ka hāʻawi ʻana i ka hoʻomaha o ka moena a, inā pono, iv ka hoʻokele wai (saline infusion). ʻO ka hypotension arential he contraindication no ka mālama ʻana me Diroton®, akā naʻe, hiki ke koi iki i kahi manawa iki, a i ʻole ka hōʻemi ʻia ʻana iho.

ʻO ka maʻi Diroton® e contraindicated ma ka hihia o ka ʻano cardiov a me ka mahele myocardial infarction, inā he koho nui ʻia ka vasodilator e hiki ke hoʻonui i ka hemodynamics, no ka laʻana, ka nui o ke koikoi o ka systolic ʻaʻole iʻoi aku i ka 100 mmHgg. ʻAniā.

I ka poʻe maʻi me ka maʻi myocardial akala, kahi hōʻemi i ka hana renal (plasma creinine concentrations ʻoi aku ma mua o 177 μmol / L a me / a proteinuria paha o 500 mg / 24 h) he contraindication no ka hoʻohana ʻana o ka lāʻau Diroton®. I ka hihia o ka hiki ʻana o ka hana ʻole i ka wā o ka mālama ʻana me ka lisinopril (ʻo ka ʻike ʻana o ka creatinine i loko o ke koko koko he ʻoi aku ma mua o 265 μmol / L a ʻelua paha o ka hoʻomaka mua ʻana), pono ke kauka ke hoʻoholo i ka pono o ka ʻohi ʻana i ka mālama ʻana.

Me ka stenosis renal bilal aals stenosis a me ka stenosis hana ʻole o ka pūpū hoʻokahi, a me ka hyponatremia a / a me ka hoʻemi ʻana i ka bcc a i ka holo ʻole ʻana, na hypotension arterial i kumu o ka lawe ʻana i ka lāʻau ʻo Diroton® hiki ke alakaʻi i ka hana hana ʻole me ka hoʻomohala ʻana i hope (ma hope o ka hōʻemi ʻia ʻana) nele. Ka liʻiliʻi iki o ka hoʻonui ʻana i ka urea i ka koko a me ka mea hana i ʻike ʻia i loko o nā hihia o ka hana renal impaired, ʻo ia hoʻi e kū'ē i ke kumu o ka hoʻomohala ʻano me ka diuretics.I nā hihia o kahi hōʻemi nui o nā hana renal (CC ma mua o 30 ml / min), e mālama ʻia a mālama pono i ka hana ʻoi.

ʻO Angioedema o ka maka, nā wāwae, nā lehelehe, ka alelo, ka epiglottis a me / a i ʻole larynx i loaʻa i ka poʻe maʻi nā maʻi me A inhibitors, me ka laʻa ʻo Diroton®, hiki ke loaʻa i kēlā me kēia manawa i ka wā mālama. Ma kēia hihia, pono e hoʻōki i ka mālama ʻana me Diroton® i ka wā hiki loa a nānā pono ʻia ka mea maʻi a hiki i ka hōʻoli ʻana o nā hōʻailona. I nā hihia i loaʻa ai ka ʻano o ke alo wale nō o ka maka a me nā lehelehe, e hele pinepine aku ke kūlana me ka loaʻa ʻole o ka mālama ʻana, akā naʻe, hiki ke kahakaha nā antihistamines. ʻO ka edion Angioneurotic me ka laryngeal edema e hiki ke make. Ke uhi ʻia ka alelo, a me epiglottis a i ʻole larynx, hiki i ka ala ke ala, no laila, e lawe koke ʻia ka lāʻau kūpono (0.3-0.5 ml o ka epinephrine (adrenaline) i ka hopena 1: 1000 s / c, ka hoʻokō ʻana o GCS, antihistamines) a me / a i ʻole nā ​​hana e hōʻoia i ka ala o ke ala. ala. I ka poʻe maʻi me ka mōʻaukala o ka angioedema i hoʻopili ʻole ʻia me ka mālama mua ʻana me ka ACE inhibitors, e hoʻonui ʻia ka nui o kona hoʻomohala ʻana i ka wā o ka mālama ʻana me kahi ACE inhibitor.

Ua ʻike ʻia ka hopena anaphylactic i loko o nā mea maʻi e hana ana i ka hemodialysis e hoʻohana ana i nā membraes dialy high-flow (AN69®), ka mea hana i ka Diroton®. I kēlā mau hihia, pono e noʻonoʻo ʻia e hoʻohana i kahi ʻano ʻokoʻa o ka dialysis membrane a i ʻole nā ​​mea antihypertensive aila ʻē.

I kekahi mau pilikia desensitization e pili ana i nā arensropod allergens, e mālama ʻia ana ka mālama ʻana me ACE inhibitors e nā ʻano like hypersensitivity. Hiki ke pale aku kēia inā pale iki ʻoe i ka lawe ʻana i ka pale ACE.

I nā mea maʻi me ka hoʻomanawanui ākea a i ʻole ma ka anesthesia aoao, hiki i nā mea paʻa ACE (ke ʻano, lisinopril) hiki ke kāohi i ka hoʻokumu ʻana o ka angiotensin II. ʻO ka emi o ke kahe o ke koko i pili me kēia hana o ka hana i hoʻoponopono ʻia e ka hoʻonui ʻana o ka bcc. Ma mua o ka wehe ʻana (e komo pū ana me ka dentist), pono e hoʻoponopono ʻia i ka anesthetist e pili ana i ka hoʻohana ʻana i ka lāʻau Diroton®.

ʻO ka hoʻohana ʻana i nā pona ʻāpono i hōʻike ʻia i nā mea maʻi ma nā poʻe maʻi hiki ke hele pū me ka piʻi o ka neʻe ʻana o ka lisinopril i ke koko, no laila ke koho pono ʻia nei e kūlohelohe a lawe ʻia e pili ana i ka hana a ke kanaka maʻi a me ke koko. Eia nō naʻe, i ka poʻe maʻi a me nā poʻe ʻōpio, ʻo ka hopena antihypertensive o ka Diroton® ka huaʻōlelo.

Ke hoʻohana nei i ka hana ACE inhibitors, i ʻike ʻia ka pākaukau (maloʻo, lōʻihi, e nalo ana ma hope o ka mālama ʻana me ACE inhibitors. Me kahi maʻi hoʻololi ʻana o ka ʻōpala, pono e noʻonoʻo ʻia ka make e ka hoʻohana ʻana o nā inhibitor ACE.

I kekahi mau hihia, ua hoʻomaopopo ʻia ka hyperkalemia. Hoʻokomo ʻia nā mea pilikia no ka hoʻomohala ʻana i ka hyperkalemia i ka male ʻana o ka pōʻaiʻai, ka maʻi mellitus, ke kīhū ʻakai, a me nā lāʻau lapaʻau e hoʻonui ai i ka paʻakai koko (e like me ka heparin), aemaise i nā mea maʻi me ka hana pūpū maʻi.

I ka wā o ka mālama ʻana me ka lāʻau lapaʻau, mālama pono ka paʻū o ka potassium, glucose, urea, lipids i ka plasma koko.

I ka wā o ka mālama ʻana, ʻaʻole i kuhikuhi ʻia e inu i nā ʻawaʻawa, ʻoiai hoʻonui ka ʻākena i ka hopena hypotensive o ka lāʻau lapaʻau.

Pono e mālama pono i ka wā mālama i ka hoʻomaʻamaʻa kino ʻana i ka wā wela (ʻo ka ʻeha o ka puʻe ʻana a me ka nui o ke kaʻe o ke koko ma muli o ka emi ʻana o ka bcc).

Ma muli o ka hiki ʻana o ka mehe e pili ana i ka agranulocytosis i ʻole e hoʻoholo ʻia, koi ʻia ka nānā ʻana i ka manawa koko.

Inā hele mai nā hopena ʻino mai ka kikowaena o ka nūnaehana kikowaena, ʻaʻole ʻia ke alakaʻi i nā kaʻa a hana i ka hana i pili pū ʻia me ka nui o ka piʻi.

Nā hōʻailona: hōʻailona hōʻailona i ka hoʻokahe nui o ke koko, ka malo maloʻo, ka lūlū, ka mālama ʻana i ka urinary, constipation, hopohopo, hoʻonui i ka huhū.

Hoʻomaʻamaʻa: lavage gastric, lawe i ka charcoal hoʻōla, hāʻawi i ka mea maʻi i kahi kūlana e kū pono ana i nā wāwae i hāpai ʻia, hōʻano hou i nā bcc (iv ka hoʻokō ʻana i nā ʻōnaehana plasma-hoʻololi), nā hōʻailona maʻi, ka nānā ʻana i nā hana o nā ʻōkole cardiovascular me ka hanu, bcc, urea, nā mea hana a me nā electrolytes serum. me nā diuresis. Hiki ke huki i ka Lisinopril mai ke kino ma o hemodialysis.

Me ka hoʻohana like pū me ka diuretics potassium-sparing (spironolactone, triamteren, amiloride), mākaukau pākui, nā paʻakai paʻakai e loaʻa ana i ka potassium, ka piʻi ʻana o ka hoʻoulu ʻana i ka hyperkalemia hoʻonui, keu i nā mea maʻi me ka hana pūpū maʻi ʻole. No laila, hiki i ke kākau inoa ʻana ke hiki wale ma ka papa o ka hoʻoholo a kahi kanaka iho me ka nānā pinepine ʻana i ka serum potassium a me ka hana ʻana o ka pūpū.

Me ka hoʻohana like pū me nā beta-blockers, nā laka hāleo palaka lemu, diuretics a me nā lāʻau antihypertensive, he hoʻonui i ka hopena hypotensive o ka lāʻau.

Me ka hoʻohana pū ʻana o ka ACE inhibitors a me nā hoʻomākaukau gula (sodium aurothiomalate) iv, ua hōʻike ʻia kahi hōʻailona koʻikoʻi, e komo pū ana me ka maka, ihu, ka luaʻi, a me ka hypotension arterial.

Me ka hoʻohana like pū me nā vasodilators, barbiturates, phenothiazines, antidepressants tricyclic, ethanol, hoʻonui ʻia ka hopena hypotensive o ka lāʻau lapaʻau.

Me ka hana like me nā NSAIDs (me nā mea koho COX-2 pipili), nā estrogens, a me nā agonist adrenergic, kahi i hoʻemi ʻia ka hopena antihypertensive o ka lisinopril.

Me ka hoʻohana like ʻana me ka hoʻomākaukau lithium, ka hoʻopau ʻana o ka lithium mai ke kino i ka haʻahaʻa (piʻi i ka hopena cardiotoxic a me ka neurotoxic lithium).

Me ka hoʻohana like ʻana me nā antacids a me colestyramine, hoʻemi ʻia ka pale ʻana i ka pānaʻi ʻana.

Hoʻonui ka lāʻau lapaʻau i ka neurotoxicity o nā salicylates, nāwaliwali i ka hopena o nā aihue hypoglycemic no ka hoʻopuka waha, norepinephrine, epinephrine a me nā lāʻau anti-gout, hoʻonui i nā hopena (e komo pū ana i nā hopena ʻaoʻao) o ka glycosides cardiac, ka hopena o nā hoʻomaha sela pelipalal, a me ka hōʻemi ʻana i ka excretion o quinidine.

Hoʻemi i ka hopena o nā mea hoʻohālikelike waha.

Me ka hoʻomohala pinepine ʻana o ka methyldopa, e piʻi aʻe ka ʻalā o ka ulu ʻana o ka hemolysis.

Ke kūleʻa aku nei ka lāʻau lapaʻau.

Papa inoa B. Pono e mālama ʻia ka lāʻau lapaʻau mai ka hiki ʻana o nā keiki i ka mahana mai ka 15 ° a 30 ° C. ʻO ka lā kau - 3 mau makahiki

Lisinopril a me Diroton, he aha kaʻokoʻa?

ʻO Lisinopril kahi lāʻau lapaʻau i loaʻa ka natriuretic (kahi kinai o nā sodium sodium mai ke kino e ka ʻōpū), cardioprotective (pale i ka naʻau naʻau) a me ka hypotensive (hoʻohaʻahaʻa i ke koko) ka hopena.

ʻO ka Diroton kahi lāʻau lapaʻau me ka peripheral (mamao) kahi vasodilating (ka hoʻomaha ʻana i nā māla neʻe o nā paia o nā kīʻaha koko) a he hopena hypotensive ma ke kino o ke kanaka.

• Lisinopril - ʻo ka mea whakakeke i kēia lāʻau lapaʻau ka lisinopril dihydrate. Hoʻohui maikaʻi, ka hoʻohui ʻia ʻana o nā mea pono e hāʻawi ai i ke ʻano o ka hoʻokuʻu i ka leo. ʻO ka lāʻau lapaʻau i hana ʻia e nāʻoihana lāʻau lapaʻau Lūkini.
• Diroton - ka mea hana hoʻomehana i kēia lāʻau lapaʻau ʻo lisinopril. Eia kekahi, e hāʻawi i ke ʻano o ka ʻoi aku i ka lapaʻau, hiki i nā mea hoʻohui loa ke hoʻohui ʻia. Hoʻohana ʻia ka lāʻau lapaʻau e ka hui apotekineka ʻo ʻo Rich Richter (Hāpai).

Nā hana hana i ka hana

Lisinopril - ka waiwai hana o kēia lāʻau lapaʻau, hōʻemi i ke kaʻina hana e hoʻokuʻu ai i ka aldosterone (he hormone adrenal nona ke kuleana wai a me ka meona, me ke koʻīwī ʻana o nā moku peripheral), e hōʻemi ana i ka nui o nā sodium i nā wai i ka wai i loko o ke kino o ke kanaka, e hoʻopiʻi ai i ka nui o ka bcc ( ka nui o ke kahe huakaʻi) e hoʻonui nui i ka luhi ma ka puʻuwai. Eia kekahi, hoʻomaha ka lisinopril i nā mākia maʻa o nā paia o nā kīʻaha koko, e hōʻemi ana i ke koko.

Diroton - ʻoiai ma kēia lāʻau lapaʻau, ka lisinopril is the activeanthation, ua ʻano like kona ʻano hana me ka lāʻau lapaʻau i luna aʻe.

• Hypertension arterial (kahi maʻi i hōʻike ʻia e ka hoʻomau mau o ka neʻe koko),
• Hoʻopau ʻole nā ​​puʻuwai naʻau
• E like me ka mahele o ke ʻano paʻakikī, i ka mālama ʻana i ka maʻi myocardial nui ʻole.
• ʻO Nepropathy (pōʻino hōʻino ma muli o ka maʻi maʻi).

• Hoʻohālikelike nā ʻōmole i ka lāʻau o luna.

Nā Hoʻohui

• Hypersensitivity i nā māhele o ka lāʻau lapaʻau,
• Ka lule a lactose.

• Ke hoʻomanawanui ʻole ʻana o nā mea āpau o ka lāʻau,
• ʻLelo ʻia a me ka lactation,
• He predisposition hope loa i ka Quincke edema (kūkaʻi maʻi kūlohelohe, hōʻike ʻia e ka edema o ka ʻōpū hanu kiʻekiʻe),
• ʻAno (ʻaʻole i hoʻouna ʻia i nā keiki ma lalo o 18 mau makahiki).

Nā hopena hopena

• Nā kumumua pā (Allness, rash, and itching on the skin),
• Nā kuʻuna o ka dyspeptic (hoʻomehana, ka luaʻi, ka ʻeha a i ka constipation, flatulence a me ka pua ʻana, i ke ʻeha i loko o ka ʻōpū),
• Puhi, pale,
• ʻO ka hoʻomohala ʻana o ka infococote myocardial (inā ua nui ke kaʻi i nā mea maʻi me ka maʻi ʻōpū coronary).
• ʻO ka luhiluhi, luhi,
• ʻEha ma hope o ka sternum
• Hoʻopili iki i ka hanu
• Kāmole maloʻo
• ʻO Tachycardia (hoʻonui i ka nui o ka puʻuwai) a i ʻole ka bradycardia (hoʻemi i ka helu puʻuwai),
• Kau ka momona
• Hoʻonui kaho
• ʻO ka lauoho lauoho
• Hōʻailona Erectile (male makemake) i nā kāne,
• ʻEha ka naʻau
• Photophobia.

• Hoʻohālikelike nā hopena ʻaoʻao i ka lāʻau o luna.

E hoʻokuʻu i nā palapala a me ke kumukūʻai

• 5 mg papa, 30 pcs, - "mai 89 r",
• 10 mg papa, 30 pcs, - "mai 115 r",
• 10 mg papa, 60 pcs, - "mai 197 r",
• Nā papa o 20 mg, 30 pcs, - "mai 181 p."

• 2,5 mg papa, 28 pcs, - "mai 105 r",
• 5 mg papa, 28 pcs, - "mai 217 r",
• 5 mg papa, 56 pcs, - "mai 370 r",
• 10 mg papa, 28 pcs, - "mai 309 r",
• 10 mg papa, 56 pcs, - "mai 516 r",
• 20 mg papa, 28 pcs, - "mai 139 r",
• Nā papa o 20 mg, 56 pcs, - "mai 769 p."

ʻO Diroton a i Lisinopril paha - ʻoi aku ka maikaʻi?

I mea e hoʻoholo ai ʻo wai ka lāʻau antihypertensive ʻoi aku ka maikaʻi, pono e hoʻomaopopo i kā lāua mau ʻokoʻa, ʻoiai ʻo kēia mau lāʻau ke loaʻa ka ʻano like o lākou, a e like me nā ʻike a me nā hopena like.

Nui ka poʻe i manaʻo kuhihewa i kēia mau lāʻau i nā analogues (nā lāʻau me nā mea ikaika like ʻole, akā ʻo nā hōʻailona like), pololei ia e kapa ʻia lākou he generics (ʻo ka mea ola like ʻole, nā inoa kālepa like ʻole).

Ma keʻano holoʻokoʻa, ʻo ka ʻokoʻa ma waena o nā lāʻau lapaʻau ka contraindications. ʻAʻole pono e hāʻawi ʻia ʻo Lisinopril i ka poʻe me ka intolerance lactose. Ma ka huli ʻana, ua pāpā ʻia ʻo Diroton i nā kānaka me ka makemake hoʻoilina no ka edema Quincke.

Hana ʻia ʻo Lisinopril e nā hui ʻo Lūkia, a ua hana ʻia ʻo Diroton ma Hungary, no laila ʻoi aku ka kiʻekiʻe o kāna kumukūʻai. Akā ʻaʻole pili kēia i ka hana pono.

Lisinopril a i ʻole Diroton - ʻoi aku ka maikaʻi? Hoike Mai

Ma muli o nā loiloi e pili ana i kēia mau lāʻau, hiki iā ʻoe ke loaʻa kahi kiʻi hoʻohālikelike o ʻoi aku ka maikaʻi o ka lāʻau lapaʻau.

• ʻO ke kumu kūʻai haʻahaʻa
• ʻO ka wikiwiki o ka hopena therapeutic.

• ʻAʻole kūpono no nā poʻe me ka intolerance lactose.

• Nā liʻiliʻi contraindications
• ʻOi kūpono.

ʻO ka hana o ka laikini mālama kino a me ka lisinopril generic i ka monotherapy a me ka hui pū me ka hydrochlorothiazide i nā mea maʻi me ka hypertension arterial

A.A. Abdullaev, Z. J. Shahbieva, U. A. Islamova, R. M. Gafurova
ʻO ka wahine hoʻokele olakino ʻo Dagestan, Makhachkala, Rusia

Hoʻāla manaʻo
Kumuhana: e hoʻohālikelike i ka holomua, palekana a me ka hoʻonaʻauao pharmaco-ʻekekema o ka mālama ʻana me ka laikini a me ka generic ACE inhibitors lisinopril (Irumed (Belupo) a me Diroton (Gideon Richter) e like me ka monotherapy a me ka hui pū me ka hydrochlorothiazide i nā mea maʻi me ka helu 1-2 arterial hypertension.
Nā pono hana a me nā ʻano: Ua hoʻokomo ʻia nā mea maʻi he 50 me AH o ka 1-2 tbsp ma kahi paʻa no ka hoʻopaʻa ʻia ʻana. (22 kāne a 28 wahine) 35-75 mau makahiki keu, me ka lōʻihi o ka hypertension o 7.1 ± 3.3 mau makahiki. ʻEono mau mea maʻi i haʻalele i ke aʻo ʻana: 2 ma ke kua o ke ʻano maʻi me Irumed a me 4 ma ka ʻaoʻao o ke ʻano me ka Diroton. Ua mālama ʻia ka ʻike ʻana i kēlā me kēia lā i ke koko (BPM) me ka hoʻohana ʻana i nā mea hana SL90207 a me 90202 (SpaceLabsMedical, USA).
Nā hopena: hana me ka Iramed i alakaʻi i kahi nui o ke kahe nui o ke koko (-27.8 ± 8.6 / -15.1 ± 6.9 mm RT.Art.) Hoʻohālikelike me Diroton (-21.1 ± 6.9 / -9.0 ± 5.9 mm Hg), pHopena: Hōʻike ʻia me ka maʻi ʻĀina i loko o nā poʻe maʻi me ka AH o ka 1-2 koʻikoʻi o ka hopena antihypertensive maikaʻi loa a ʻoi aku ka maikaʻi o ka pharmacoeconomically ma mua o ka Diroton therapy.
Huaʻōlelo kī: hypertension arterial, lisinopril, Irumed, Diroton.

Koi: e hoʻohālikelike i ka hana pono a me ka ʻae ʻana o ka laikini mālama lapaʻau a me ka licin licin Ain inhibitor lisinopril (Irumed, Belupo a me Diroton, Gedeon Richter) i ka monotherapy a me ka hui pū me ka hydrochlorothiazide ma nā mea maʻi me ka hypertension arterial (AH).
Nā pono hana a me nā ʻano: ua wehe ʻia ka hoʻokūkū manuahi noiʻi ʻia he 50 mau mea maʻi me ka AH (22 kāne a me 28 mau wahine he 35-75 mau makahiki) o ka lōʻihi o ka manawa 7.1 ± 3.3 mau makahiki. Ua haʻalele ka mea maʻi 6 i ka noiʻi (Irumed -2 ​​a me Diroton - 4). Ua nānā ʻia ka neʻe koko (BP) no 24 mau hola me ka polokalamu SL 90207 a me 90202 (SpaceLabs Medical, USA).
Nā hopena: ʻOi aku ka nui o ka hōʻemi i ka haukapila o ka BP (-27.8 ± 8.6 / -15.1 ± 6.9 mm Hg) ma mua o Diroton (-21.1 ± 6.9 / -9.0 ± 5.9 mm Hg ), pHopena: Hoʻomaʻamaʻa ka hopena Iruming i ka hopena maikaʻi loa a me ka uku hoʻēmi ma mua o ka lāʻau Diroton i nā maʻi me nā pae 1-2 arterial hypertension.
Huaʻōlelo nui: hypertension arterial, lisinopril, Irumed, Diroton

ʻIkepili e pili ana i nā mea kākau
Abdullaev Aligadzhi Abdullaevich - Kauka med. ʻepekema, poʻo. Ke Keʻena ʻOihana Ola Lapaʻi, Cardiology a me nā Kauka Hoʻolapa Nui
ʻO GOU VPO Dagestan State Medical Academy
ʻO Shakhbieva Zarema Yusupovna - haumāna haumāna o ia keʻena like
ʻO Islamova Ummet Abdulhakimovna - Cand. meli ʻepekema, kōkua i ke ʻano ʻoihana like ʻole. 367030, RD, Makhachkala, I. Shamily Ave., 41, apt. 94.
Gafurova Raziyat Magomedtagirovna - Cand. meli ʻepekema, kōkua i ke ʻano ʻoihana like ʻole. 367010, RD, kulanakauhale o Makhachkala, ul. Mendeleev, d.12.

Hoʻomau
ʻO ka hana maʻi o nā poʻe maʻi me ka arertial hypertension (AH) i kahi hana i kēia manawa, no ka mea e hiki ke hōʻea i ka make cardiovascular (SS) ma kahi o 40%, a me ka lawa kūpono kūpono a me ka palekana, e pili ana ia i nā mea pilikia e hoʻololi ʻia no ka hoʻomohala ʻana i ka maʻi naʻau coronary ( IHD) a me nā maʻi SS ʻē aʻe. Ua hōʻike ʻia nā hopena o nā noiʻi he pono ka maʻi monotherapy ma kahi ʻāpana liʻiliʻi (e pili ana i 30%) o nā mea maʻi me ka hypertension 2, 3. ʻO ka hoʻohana ʻana o nā lāʻau ʻelua ke hiki ke loaʻa i ka pae o ka nui o ke koko (Ma hope o ka pau ʻana o ka manawa ʻoihana pale, hiki i kekahi hui lāʻau lapaʻau ke hana a kūʻai aku i ka lāʻau lapaʻau. I ka hopena, pono ke kūʻai ʻia i nā lāʻau like ʻole o nā mea hana i loko o nā lāʻau lapaʻau, a hiki ke hōʻeha maoli kēia mau lāʻau i ka pono a me ka palekana. ka waiwai o ka lāʻau lapaʻau, hōʻike ʻia i loko o nā hoʻokolohua lapaʻau lapaʻau e ʻike ʻia, e pili ana i nā lāʻau lapaʻau mua a me nā lāʻau lapaʻau i hana ʻia ma lalo o ka laikini. Pono nā lāʻau lapaʻau e hōʻoia i ka hopena e like me ka hoʻohālikelike mua ʻana me nā mea mua. ua malu ia, e like me ka mea ma mua, a hiki iā ʻoe ke puʻunaue i ka ʻikepili i loaʻa ma ka lāʻau lapaʻau mua iā ia. ʻO ka mea pōʻino, me kahi helu liʻiliʻi o nā lāʻau lapaʻau, ua hoʻokō ʻia nā noiʻi like like.

I kēia mau makahiki i hala iho nei, ua manaʻo nui ʻia nā kihi waiwai i loko o ka lāʻau lapaʻau. Maʻalo ʻia kēia e ke kālā palena o nā ʻoihana olakino a ma ka hapa nui loa, nā kumuwaiwai waihona o ka mea maʻi iā ia iho. Ke hoʻopau nei i kēia pilikia i ke kūlana i kēia manawa, pono ia e noʻonoʻo pono ʻaʻole i nā hopena lapaʻau a me ka palekana o kahi lāʻau lapaʻau wale nō, akā ʻo ka hopena ʻonaʻāina hoʻi i ka mea maʻi a me ka mālama olakino. Pono ke ʻano ʻoihana lapaʻau kūpono e pili ana i ka maʻi ma muli o pharmacoeconomics 7, 8

ʻO ke kumu noiʻi - hoʻohālikelike i ka hana pono, palekana a me ka hōʻoia o ka pharmacoeconomic o ka mālamaʻana me ka laikini a me ka laikini ACE inhibitors lisinopril (Irumed (Belupo) a me Diroton (Gideon Richter) i ke ʻano o ka monotherapy a me ka hui pū me ka hydrochlorothiazide i nā mea maʻi me ka pae o ka hypertension 1-2 arterial.

Mea hana a me nā ʻano: nā haʻawina i komo ai i nā maʻi he 50 me ka hypertension o 1-2 koʻikoʻi, he 6 nā poʻe maʻi i hoʻokuʻu i ka wā o ka hahai ʻana: 2 i ka wā e mālama pū ai me Irumed a me 4 i ka wā mālama me Diroton. Loaʻa kahi 44 o nā mea maʻi i hoʻopau i ka noiʻi I ka mua, ʻaʻole i like nā hui i nā ʻokoʻa i ka wā o ka makahiki, nā kāne, a me nā ʻano ʻē aʻe (Papa Papa 1).Ke komo pū nei ka haʻawina i nā maʻi 18-75 mau makahiki me ke maʻi hypertension hou a i ʻole mau i lawe i ka lāʻau antihypertensive i loko o ka mahina i hala. I ka manawa hoʻokomo, ʻo ka hui o ka hui o ka systolic blood pressure (SBP) ma ke kūkaʻi (papa) he 158.5 ± 7.5 mm Hg. Art., Ke dihe koko diastolic (DBP) C. 97.5 ± 5.0 mmHg. Art., Puʻuwai puʻu 74.7 ± 8.8 mau kui / min. ʻO nā kumu o ka wehe ʻana: nā puka pae lua o ke hypertension, ʻo ka ulia o ka cerebrovascular ulia, ka hala o ka myocardial infarction i nā mahina 6 hope loa, ka angina pectoris II-III FC, ka puʻuwai puʻuwai, ka arrhythmias cardiac, nā ate a me ka hana.

Papa 1. ʻO ke ʻano lapaʻau mua a me ka demographic a me nā hiʻohiʻona o nā hui

Hoʻolālā: ka hana noiʻi manuahi, wehe ʻia i mua, koho, a hana ʻia e like me nā kānāwai GCP (Maikaʻi Kino Hana Kūleʻa) a me ka 2000 Helsinki hoʻolaha. ʻO ka lōʻihi o ka nānā ʻana he 24-25 mau pule. Ma mua o ke komo ʻana i ka noiʻi ʻana, ua hōʻiliʻili ʻia ka mōʻaukala olakino holoʻokoʻa i nā maʻi āpau, ua hoʻokō ʻia kahi hōʻike kino, ʻike ʻia ke koko e ke ʻano ʻo Korotkov, a ma hope e ʻike i nā mea maʻi i ʻike ai i nā paʻa o ke komo ʻana a ʻaʻole i loaʻa nā laʻa i hoʻohiki paʻa ʻia i nā hui like like, ʻo ka mea mua i hoʻomaka i ka mālama ʻana me Iramed a me ka lua me Diroton ma kahi kūpono o 10 mg / lā. Ma hope o 2 mau pule, i ka loaʻa ʻole i ka pae o ka pae koko o ka nui (ua hoʻākāka ʻia ke koko o ke olakino e like me ka awelika o 3 mau ana o ke kao o ke koko me ka sphygmomanometer manual ma kahi kūlana e noho ana ma hope o nā minuke 10-15 o ka hoʻomaha, a kū pū nō hoʻi, 1 mau minuke ma mua o ka lawe ʻana i ka lāʻau lapaʻau i ka lā o ka kipa. no nā koina koko AD, lawe lākou i ka hōʻemi ma nā pūʻulu DBP ma o 10% ko 10 mm mau mau Hg a me nā huaʻelima GARDEN e 15 mm Hg mai ka pae mua. hōʻano uila papahana ʻo Statistiсa 6.0 (Statsof t, USA) hoʻolako ʻia no ka hiki ʻana o ka parametric a me ke ʻano nonparametric.ʻO ka manaʻo i manaʻo ʻia he mea nui i ka pNā hopena a me nā kūkākūkā

ʻO nā lāʻau ʻelua i hoʻopaʻa ʻia me ka hopena antihypertensive maikaʻi, i hoʻonui ʻia e ka neʻe ʻana o nā mea maʻi e hui pū ai i ka maʻi. Hōʻike nui ʻia i ke kahe koko nui e like me ka cl. HELL, a e like me ka Smad. Ma hope o 2 mau pule o ka lisinopril ma kahi o 10 mg / lā i loko o ka hui Irumed, hōʻemi ke koko i ka 158.4 ± 7.4 / 98.2 ± 4.4 mm Hg. ʻAniā. a hiki i 146.1 ± 9.1 / 93.1 ± 6.1 mmHg. ʻAniā. (pPalapala 2. Nā kumukanawai o ke koko. i ka wā o ka mālama ʻana me Irumed a me Diroton.