Lisinopril - he aha kēia mau peni? Nā ʻōkuhi no ka hoʻohana, nā analogues, nā loiloi

Nā ʻōkuhi no ka hoʻohana:

Nā kumukūʻai ma nā lāʻau lapaʻau pūnaewele:

ʻO Lisinopril kahi hoʻomehana hoʻohālikelike i ka hoʻoneʻe ʻana i nā enzyme (ACE) e hōʻemi ana i ka hoʻokumu ʻana o ka angiotensin II mai nā angiotensin I.

E hoʻokuʻu i ke ʻano a me ka ʻano

Ka ʻano ʻai o ka Lisinopril - papa: pālahalaha, pōʻai, a me nā kihi beveled, me ka pilikia o kekahi ʻaoʻao (10 mau p. In blisters, in a cardble 2, 3, 4, 5 or 6 packets, 14 pcs. pūpū ʻai, i kahi ʻāpana kāleka o 1, 2, 3 a i ʻole 4 kīʻaha paha).

ʻO ka mea hana ikaika o ka lāʻau lisinopril i ke ʻano o kahi dihydrate. ʻO kona mea i loko o nā papa, e pili ana i ke kala:

• Kūmole ʻeleʻele 2.5 mg
• ʻĀuki 5 mg
• Kāpuka - 10 mg
• Keokeo paha keʻokeʻo paha - 20 mg.

ʻO nā mea kōkua: lactose monohydrate, mais starch, methylene chloride, povidone, magnesium stearate. Ma nā papa o 2,5 a me 5 mg, ma kahi, nā kahe o ka lā ma lalo o ka wai i loko o nā papa he 10 mg - dye azorubine, i loko o nā papa o 20 mg - titanium dioxide.

Nā hōʻailona no ka hoʻohana ʻana

• Hoʻomaka (ma nā hola 24 mua) ka mālama ʻana i ka maʻi myocardial akene i ka poʻe maʻi me nā neʻe hemodynamic mau (ma ke ʻano he hui hoʻohui i mea e mālama ai i kēia mau kuhikuhi a pale aku i ka hāʻule ʻole o ka naʻau a haʻalele i ka disopunction ventricular)
• Hōʻeha ka puʻuwai hōʻeha (ma ke ʻano o ka hōʻeha paʻakikī),
• ʻO ka renovascular a me ka pono arertial hypertension (ʻoiai me ka lāʻau hoʻokahi a i hui pū ʻia me nā lāʻau antihypertensive),
• ʻO nephropathy Diabetic (e hōʻemi i ka albuminuria i nā mea maʻi me ka type i ke ʻano maʻi diabetes mellitus me ke ʻano o ke koko maʻamau a me nā mea maʻi me ka maʻi diabetes mellitus type II me ke ʻano o ka arterial hypertension).

Nā Hoʻohui

• Hema malia idiopathic edema a i Quincke angioedema,
• ʻO ka mōʻaukala o ke angioedema, ʻo ia hoʻi ma muli o ke hoʻohana o nā inhibce ACE,
• Ka lactose intolerance, glucose-galactose malabsorption, hemahema lactase,
• Ke lalo o 18 mau makahiki
• Kahawai
• Hoʻokaumana
• Hypersensitivity i nā mea o ka lāʻau lapaʻau a i ʻole nā ​​mea ʻē aʻe o ACE inhibitors.

Pili (mālama pono)

• Mamua
• Hypertrophic obstructive cardiomyopathy,
• Stenosis o nā aific aortic,
• Hipotina arterialia,
• ʻO ka huhū o ka puʻuwai koʻikoʻi,
• ʻO ka maʻi ʻeha Coronary
• ʻO ka maʻi cerebrovascular (me ka haʻahaʻa o ka cerebrovascular)
• Hōʻailona o ka iwi heula hematopoiesis,
• Palapala Kahuna,
• Naʻi maʻi mellitus
• ʻO nā maʻi ʻōnaehana o ka kiko huina (me ka scleroderma a me ka systemus lupus erythematosus),
• Hyperkalemia
• Hyponatremia,
• Nā kūlana Hypovolemic (me ka hoʻopili ʻana a me ka luaʻi)
• ʻO ka molateral o ka hāmeʻe o ka lua a me ka stenosis o ka lāʻau o ka mōʻī hoʻokahi kūʻai, hōʻeha nui o ka renal (ʻoi aku ka hana o ka hana ma lalo o 30 ml / min), ke ʻano ma hope o ka hoʻololi ʻana o ka huehue,
• ʻO Hemodialysis, e hoʻohana ana i nā membra dialy high-flow (AN69).

ʻLoe a me ke kākele

Pono ka lā i lawe ʻia ʻo Lisinopril i ka manawa i ka lā i kēlā me kēia lā, no ka ʻai ʻana o ka meaʻai, akā maikaʻi ʻia i ka manawa like o ka lā.

Hoʻomaka ka mālamaʻana i ka maʻi hypertension maʻamau i kēlā me kēia lā no 10 mg. ʻO ka dosis mālama ka 20 mg, ʻo ka nui o kēlā me kēia lā he 40 mg. Me ka hoʻonui nui o ka waiū, he mea nui e noʻonoʻo e hoʻomohala ʻia kahi hopena hypotensive ma hope o 1-2 mau mahina o ka lapaʻau. Inā lawe ʻoe i ka ʻai nui o kēlā me kēia lā ma ka hopena o ka laʻana, ʻaʻole hiki i ka lāʻau hou ke hoʻonui aku i kekahi laikini antihypertensive. ʻO nā mea maʻi i loaʻa i ka diuretics ma mua, 2-3 mau lā ma mua o ka wā i koho ʻia ai kēia lāʻau lapaʻau, pono lākou e hōʻa ʻia. Inā hiki ʻole kēia, a laila ʻaʻole pono ka lāʻau mua o Lisinopril i ka 5 mg i kēlā me kēia lā.

ʻO ka maʻi kumu mua no ka hypovension renovascular a me nā kūlana ʻē aʻe me ka nui o nā hana me ka renin-angiotensin-aldosterone system is 2.5-5 mg i kēlā me kēia lā. Hoʻopau ʻia ka hana ma lalo o ka kaohi o ka hana renal, koko i ke koko (BP), kāmele serum. E hoʻoholo ke kauka i ka mālama mālama ʻia e pili ana i ke kahe o ke koko. I ka hopena o ka renal pilikia ʻole, e hoʻoholo ʻia ka nui o ka lā ma ke ʻano o ka cleince hana (CC): me CC 30-70 ml / min - 5-10 mg, me CC 10-30 ml / min - 2.5-5 mg, me CC me ka emi mai o 10 ml / minute a me nā mea maʻi e hele ana i ka hemodialysis - 2.5 mg. Hoʻokumu ka dosis mālama i ka neʻe koko.

Hoʻomaka ka hoʻouluʻana o ka puʻuwai naʻau me ke ʻano he 2.5 mg i kēlā me kēia lā (i ka manawa like me ka glycosides cardiac a me / a me diuretics) paha. Ma nā laha o 3-5 mau lā, e hoʻonui pinepine ia - e 2,5 mg - a hiki i ka pae mālama mālama ʻia ʻo 5-10 mg i kēlā me kēia lā. ʻO ka 20 mg ʻea loa i ʻāpono ʻia i kēlā me kēia lā. Inā hiki, pono e hoʻemi ʻia ka nui o ka diuretic ma mua o ka lawe ʻana iā Lisinopril.

I nā poʻe kahiko, ʻoi aku ka maikaʻi o ka hopena hypotensive wā lōʻihi, no laila e hōʻike ʻia ka mālama ʻana e hoʻomaka me ka wai ma kēlā me kēia lā he 2.5 mg. In myocardial infarction, ʻo 5 mg i kuhikuhi ʻia i nā hola 24 mua, 5 mg i ka lā, 10 mg i ʻelua mau lā a laila 10 mg hoʻokahi manawa i ka lā, ʻo ka papa haʻahaʻa o ka mālama kino he 6 mau pule. I ka hihia o ka emi ʻana o ka hoʻohaʻahaʻa systolic i 100 mm RT. ʻAniā. a ua hoʻemi ʻia ka lāʻau haʻahaʻa ma 2.5 mg. Me kahi lōʻihi (ʻoi aku ma mua o 1 mau hola) i hōʻemi ʻia i ka hoʻohaʻahaʻa systolic ma lalo o 90 mm RT. ʻAniā. hoʻopau ʻia ka lāʻau. No nā mea maʻi me ka hoʻohaʻahaʻa haʻahaʻa haʻahaʻa (120 mmHg. Art ma lalo), ua ʻōlelo ʻia he 2.5 mg ma ka 3 mau lā mua ma hope o ka hua ʻaila myocardial a i ʻole ka hoʻomaka ʻana o ka lapaʻau.

ʻO ka maʻa mua no ka nephropathy maʻi maʻi he 10 mg i kēlā me kēia lā. Inā pono, hoʻonui ʻia ia i 20 mg: i mea no nā poʻe maʻi me ka type I diabetes mellitus e hōʻea i kahi hōʻailona o ka diastolic pressure ma lalo o 75 mm Hg. Art., A i loko o nā mea maʻi me ka diabetes II mellitus type - ma lalo o 90 mm RT. ʻAniā. (ka ana ʻia ke kaumaha ma kahi kūlana.

Nā hopena hopena

ʻO nā hopena maʻamau ka hopena: ka nui o ka hōʻeha, ke poʻo, ka hōʻeha, ka ʻōpū, ke kuʻi, ka ʻōpū maloʻo.

• Pūnaehana Cardiovascular: ka hōʻailona hōʻemi i ke kahe o ke koko, bradycardia, tachycardia, palpitations, ʻeha ʻeha, kahi hōʻeha o ka atrioventricular, ke ʻano a i ʻole ka luhi ʻana i nā hōʻailona o ka hoʻopiʻi ʻana i ka puʻuwai, orthostatic hypotension, myocardial infarction,
• Pūnaehana neʻe waena: ka poʻohiwi puʻupuʻu e pili ana i nā lehelehe a me nā mea āpau o nā wāwae, paresthesia, asthenic syndrome, luhi i ka nānā ʻana, nui ka ʻōpū, ka hana naʻau, ke hiamoe ʻana, ka hilahila,
• Pūnaehana digestive: nā hoʻololi i ka pona, nā mukosa maloʻo, ʻeha o ka ʻōpū, dyspepsia, anorexia, jaundice (cholestatic a hepatocellular), pancreatitis, hepatitis,
• Pūnaehana genitourinary: anuria, oliguria, proteinuria, uremia, hana ʻole o ka mālamalama, hana i ʻole ke kaulike, hoʻemi ʻia ka potency,
• Pūnaehana lawelawe ʻana: ka maloo maloʻo, dyspnea, bronchospasm,
• Hematopoietic ʻōnaehana: agranulocytosis, neutropenia, thrombocytopenia, leukopenia, anemia (erythropenia, hoʻemi i ka manaʻo hemoglobin, hematocrit),
• ʻIli: photosensitivity, alopecia, hoʻonui nui, nāwaliwali,
• Nā kūmole pale: angioedema o nā mea hohonu, ke alo, nā lehelehe, ka huaʻōlelo, ka epiglottis a me / a i ʻole larynx, rashes o ka ʻili, urticaria, hoʻonui i ka ESR, ka ʻala, ka eosinophilia, nā hopena hōʻike maikaʻi no ka antibodies antinuclear, leukocytosis, angioedema intestinal,
• Nā mea'ē aʻe: arthralgia / arthritis, myalgia, vasculitis,
• Nā hōʻailona Laboratory: hoʻonui i ka hana o ka transaminases hepatic, hyperbilirubinemia, hyponatremia, hypercreatininemia, hyperkalemia, hoʻonui i ka ulu o urea.

Me ka hana like o kahi hoʻomākaukau gula (sodium aurothiomalate) intravenously me kahi mea hoʻokiʻʻo ACE, ua wehewehe ʻia kahi hōʻailona maʻi, e komo pū ana ka nausea a ka luaʻi, ka maka ihu, ka puʻu ʻulaʻa, ka hypertension arterial.

Nā ʻōlelo kikoʻī

Lisinopril ua contraindicated ma ka pīhoihoi cardiogenic a me ka hoʻōla o myocardial akene, inā ʻo ka vasodilator hiki ke hoʻopilikia kino i nā ʻāpana hemodynamic, no ka laʻana, i ka manawa o ke kahe koko systolic ʻaʻole iʻoi aku ma mua o 100 mm Hg. ʻAniā.

ʻO ka hoʻohaʻahaʻa ʻia o ke kahe o ke koko i ka wā e lawe nei i ka lāʻau lapaʻau pinepine i ka hopena i ka hōʻemi o ka nui o ke kahe mau o ke koko (BCC) i kumu o ka hoʻohana ʻana o ka diuretics, nā maʻi a me ka palaho, ka hemodialysis, a me kahi kaila o ka nui o ka paʻakai i ka meaʻai. ʻO ka maʻi me ka puʻuwai puʻuwai e loaʻa pū kekahi i ka hōʻemi i hōʻemi ʻia i ke koko. Hōʻike pinepine ʻia i nā mea maʻi me ka maʻi nui o ka hana ʻole o ka puʻuwai kani ʻole ma muli o ka hyponatremia, he hopena renal functioning a lawe ʻole i ka diuretics i nā dosis kiʻekiʻe. ʻO nā ʻano i wehewehe ʻia o nā mea maʻi ma ka hoʻomaka ʻana o ka mālama ʻana, pono e nānā ma lalo o ka mākaʻi ʻana o ka lāʻau lapaʻau, ke koho ʻana i nā pona o Lisinopril a me ka diuretics e hana ʻia me ka makaʻala nui. Pono e mālama pono nā lula like i ka lawe ʻana i ka lāʻau lapaʻau i nā mea maʻi me ka maʻi naʻau coronary a me ka cerebrovascular insufficiency, ma kahi hōʻemi o ke kaʻe koko ke alakaʻi i kahi hōʻeha a i ʻole myocardial infarction. Ma mua o ka hoʻomaka ʻana i ka maʻi, ua hoʻolako ʻia e hoʻoponopono hou i ka hoʻohuihui o ka sodium i loko o ke koko a / a hoʻohui hou i ka bcc, a laila nānā pono i ka hopena o ka hopena mua o ka lāʻau.

I ka mālamaʻana i ka hypotension araticial hōʻailona, ​​pono e hāʻawi ʻia ka hoʻomaha o ka moena, inā pono, hoʻomālamalama ʻia intravenous i kahi wai (saline). ʻO ka hypotension arterial transputtion ʻaʻole ia he contraindication iā Lisinopril, akā makemake paha i ka hoʻemi haʻahaʻa ʻana a i ʻole ka hōʻemi i ka lāʻau.

Hola renal hana (plasma creinine i ʻoi aku o ka 177 μmol / L a / a i ole proteinuria ma mua o 500 mg / 24 mau hola) i nā mea maʻi me ka maʻi myocardial infarction he contraindication i ka hoʻohana ʻana o Lisinopril. Me ka hoʻomohala ʻana o ka hiki ʻole o ka renal (plasma creinine concentrations ma mua o 265 μmol / L a i ʻole 2 mau manawa i ʻoi aku ma mua o ka pae o ka mua) i ka wā e mālama ai me kēia lāʻau lapaʻau, ua hoʻoholo ke kauka pehea e hoʻōki i ka mālama ʻana.

ʻO Angioedema o nā meaʻoi loa, ka maka, ka ʻuhane, nā lehelehe, ka epiglottis a me / a larynx ka lelo, akā hiki ke loaʻa i kēlā me kēia manawa i ka wā o ka lapaʻau. I kēia hihia, pono e hooki ʻia ka mālama ʻana a mālama pono i ka nānā ʻana i ka mea maʻi a hiki i ka hōʻailona ʻana i nā hōʻailona. Lalengeal edema hiki ke laka. Inā ka larynx, epiglottis, a i ʻole e uhi ʻia ka alelo, hiki i ka alaloa ʻana he ala, no laila, pono ke ʻano kūpono e lapaʻau ʻia a / a i ʻole nā ​​hana e hōʻoia ai i ka pono o ke ala.

Ke mālama ʻia nei me ka pale o ACE, hiki i ka hopena ke piʻi i ka agranulocytosis, no laila pono pono e mālama i ke kiʻi o ke koko.

Ma ka hihia o ka hana e hoʻonui ai i nā transaminases hepatic a i ʻole ke ʻano o nā hōʻailona o ka cholestasis, pono e oki ʻia ka lāʻau lapaʻau, no ka mea aia kahi hopena o ka hoʻomohala kū i ka jaundice cholestatic, e holomua ana i ka necrosis ngalima fulminant.

E pale pono i ka manawa holoʻokoʻa o ka hoʻohana ʻana i ka lāʻau ʻawaʻawa, ae makaʻala hoʻi i ka wā wela a i ka wā e hoʻokō ai i nā hoʻomaʻamaʻa kino, e like me hiki ke hōʻemi a me ke emi ʻana i ke kahe o ke koko ke hiki.

Wahi a nā haʻawina epidemiological, ʻo ka hoʻohana pinepine ʻana o ka ACE inhibitors me ka insulin a i ʻole ka waha hypoglycemic a hiki ke alakaʻi i ka hoʻomohala ʻana o ka hypoglycemia, ma mua o nā hebedoma mua o ka hui hoʻohui ʻana, me ka poʻe hoʻi i nā mea maʻi me ka hana pūhaʻi ʻole. No kēia kumu, pono e nānā pono nā mea maʻi me ka maʻi diabetes i ka glycemia, ʻoi aku ka malama mua o ka hoʻohana ʻana iā Lisinopril.

Ma ka hopena o nā hopena kūpono mai ka pūnaehana nū o ka pokela ololi, ua ʻoi ʻia e hōʻemi i ka hoʻokele ʻana i nā kaʻa a hoʻokō i nā ʻano pilikia o ka hana.

Hoʻohui nūhou

Hoʻopau nā beta-blockers, diuretics, nā mālani hāpana kalepa a me nā mea kanu antihypertensive e hoʻoikaika i ka hopena hypotensive o Lisinopril.

Me ka hana like o ka hoʻomākaukau ʻana i ka paʻakai, nā paʻakai paʻakai e loaʻa ana i ka potasi pālima aiʻa a i ʻole potassium-sparing diuretics. No kēia kumu, pono ke kauka kauka kau i kahi hui ʻana, a pono e mālama ʻia ka lāʻau ma lalo o ka mālama mau ʻana o ka hana a me ka neʻe o ka potassium serum.

Me ka hoʻohana like ʻana o nā vasodilators, barbiturates, antidepressants tricyclic, phenothiazine a me ka ethanol, ka hopena antihypertensive o Lisinopril. ʻO nā Antacids a me colestyramine e hōʻemi i kona laweʻana mai ka gastrointestinal tract.

ʻO nā lāʻau anti-inflammatory nonsteroidal (e komo pū ana me ka inhibitors cyclooxygenase-2), nā adrenostimulants a me nā estrogens e hōʻemi i ka hopena hypotensive o ka lāʻau.

Me ka hoʻohana like o lisinopril, e hoʻolei ana i ka hoʻopihapiha ʻana o ka lithium mai ke kino, ma muli o kāna e hoʻomaikaʻi ʻia ai nā hopena cardiotoxic a me ka neurotoxic.

Hiki ke hoʻohana pū me ka methyldopa i ka hoʻomohala ʻana o ka hemolysis, me nā selotonin reuptake selektif - ka hyponatremia koʻikoʻi, me cytostatics, procainamide, allopurinol - i leukopenia.

Hoʻonui ka Lisinopril i ka hana o nā hoʻomaha hoʻomaha peripheral, hoʻemi i ka hopena o nā ʻōpū o ka waha, hōʻemi ʻia ka quinidine excretion, hoʻomaikaʻi i ka neurotoxicity o salicylates, hoʻonāwaliwali i nā hopena hopena o ka lāʻau hypoglycemic oral, epinephrine (adrenaline), norepinephrine (norepinephrine) a me nā hopena anti-gout) . ^ E Ha yM.

Me ka hoʻohana like ʻana o Lisinopril me ka mākaukau gula, hiki ke hoʻomohala i ka hyperemia facial, nausea a me ka luaʻi, a me ka hypertension arterial.

Loaʻa nā hopena ʻaoʻao

I kekahi hihia, pono ia e mālama pono i nā papa Lisinopril. Ke hōʻike nei ke aʻo i ka hiki o nā hopena ʻaoʻao ʻē aʻe:

• nāliʻi, ʻeha,
• kauā kala wale, huʻi,
• luhi, luhi
• maloʻo maloʻo.

Kuhi loa paha ʻike ʻia nā hopena like ʻole o ka lāʻau lapaʻau.

1. Heʻeha, haunaele.
2. ʻEhaʻeha ʻeha, pōkole o ka hanu, bronchospasm.
3. Bradycardia
4. Ka haki nui ʻana o ke kahe koko.
5. Hoʻonui kaho.
6. ʻEha ka ʻōpū, nā puʻupuʻu, nā palaka.
7. ʻO ka lilo lauoho lauoho.
8. Hypersensitivity i ka radiation ultraviolet.
9. Allergic hopena pili.
10. Hoʻololi nā helu koko.

Ma mua o ka hoʻohana ʻana i ka lāʻau lapaʻau, e nīnau aku i kāu kauka. E koho ʻo ia i ka dosage kūpono no ʻoe. E kōkua kēia i ka hōʻemi o ka hopena o nā hopena pili.

Ka hana lāʻau lapaʻau

Hoʻonui ʻo Lisinopril i ka leo o nā moku peripheral a hoʻonui i ka ʻōlelo huna adrenal o aldosterone. Mahalo i ka hoʻohana ʻana i nā papa, ua hoʻemi nui ʻia ka hopena vasoconstrictor o ka angiotensin hormone, ʻoiai ke emi nei ka emi ʻana o ke aldosterone i loko o ke koko koko.

ʻO ka lawe ʻana i ka lāʻau lapaʻau e kōkua i ka hoʻohaʻahaʻa ʻana i ke koko, a me ka nānā ʻole i ke kūlana o ke kino (kū, wahahee). Hōʻalo ʻo Lisinopril i ka loaʻa ʻana o ka tachycardia reflex (hoʻonui i ka nui o ka puʻuwai).

ʻO ka emi ʻana o ke koko i ka wā o ka mālama ʻana i kahi lāʻau lapaʻau ka mea hiki i kahi mea haʻahaʻa loa o ka renin i loko o ke koko koko (kahi hormone i kūkulu ʻia i loko o nā keiki).

Nā waiwai o ka lāʻau

E ʻike ʻia ka hopena o kēia lāʻau lapaʻau ma loko o hoʻokahi hola ma hope o kāna lawelawe waha ʻana.ʻO ka hopena loa o Lisinopril e nānā ʻia i nā hola 6 ma hope o ka hoʻokele ʻana, ʻoiai e hoʻomau ka hopena o kēia hopena i loko o ka lā.

ʻAʻole ke koʻikoʻi o kēia lāʻau lapaʻau i ka piʻi wikiwiki ʻana i ke kahe o ke koko, hiki ke hoʻonui ʻia ka nui i hoʻohālikelike ʻia i ka pae ma mua o ka hoʻomaka ʻana o ka lāʻau.

Inā hoʻohana ʻo Lisinopril e nā maʻi e hōʻeha ana i ka puʻuwai naʻau, e like me ka digitalis a me ka diuretic therapy, loaʻa ia i kēia hopena: e hoʻemi ana i ka kūʻē ʻana o nā kīʻaha peripheral, hoʻonui i ke koko a me ka nui o ke koko (me ka hoʻonui ʻana i ka puʻuwai o ka puʻuwai), e hoʻemi ana i ka luhi ma ka puʻuwai, a hoʻonui i ke ahonui i ke kino i ke kaumaha kino . ^ E Ha yM.

Hoʻonui nui ka lāʻau i ka dinamika intrarenal. ʻO ka komo ʻana o kēia lāʻau lapaʻau mai ka gastrointestinal tract, ʻoiai ke nānā ʻia nei ka pae kiʻekiʻe loa o ke koko i ka pae mai 6 a 8 mau hola ma hope o ke lawelawe ʻana.

Nā ʻōkuhi no ka hoʻohana

Lisinopril (hōʻike ʻia nā mea e lawe ai i nā ʻano like ʻole o ka lāʻau) i loko o nā papa i loaʻa ka 2.5 mg, 5 mg, 10 mg a me 20 mg o ka mea hana. E lawe i ka ʻōlelo Lisinopril i hoʻokahi lā i kahi lā, ʻoluʻolu i ka manawa like.

Hoʻomaka ʻia ka lilo o ka lāʻau lapaʻau no ka hypertension koʻikoʻi me 10 mg i kēlā me kēia lā, ukali ʻia e kahi neʻe ʻana i ka mālama mālama ʻia o 20 mg i kēlā me kēia lā, ʻoiai i nā hihia koʻikoʻi, ʻae ʻia ka nui o kēlā me kēia lā o 40 mg.

ʻO nā hōʻike e pili ana i ka lisinopril ke hōʻike nei i ka hopena piha o ka lāʻau lapaʻau e hiki ke hoʻomohala i nā hebedoma 2 wiki ma hope o ka hoʻomaka ʻana o ka mālama ʻana. Inā ma hope o ka hoʻokomo ʻana i ka nui o nā lāʻau lapaʻau ʻaʻole i loaʻa nā hopena i manaʻo ʻia, hāʻawi ʻia ka hoʻohana hou ʻana o nā lāʻau antihypertensive hou.

ʻO nā mea maʻi e lawe nei i nā diuretics, 2-3 mau lā ma mua o ka hoʻomaka ʻana o ka hoʻohana ʻana iā Lisinopril, pono ʻoe e hoʻōki e lawe. Inā no kekahi kumu hiki ke hoʻopau ʻia i nā diuretics, ʻaʻole hiki ke hoʻohaʻahaʻa ʻia ka nui o ka lisinopril i kēlā lā i kēia lā.

I nā kūlana me ka hoʻonui ʻana o ka hana o ka ʻōnaehana renin-angiotensin-ald testosterone e hoʻoponopono ana i ka nui o ke koko a me ke koko, hoʻokaʻa ʻia ʻo Lisinopril i ka hoʻohana ʻana o kekahi laʻana i kēlā me kēia lā o 2.5-5 mg. Hoʻomoe ʻia ka mālama ikiʻana i ka lāʻau no kēlā mau maʻi like me ka waiwai o ke koko.

Pehea e lawe ai me nā maʻi

In renal gagal, kela i ka la i ka la lisinopril kela la i ka cleince hana a hiki ke loli i 2.5 a 10 mg o kela la.

Ke hoʻomaka nei ka hypertension arterial e lawe i ka 10-15 mg no ka lā no kahi manawa lōʻihi.

ʻO ka lawe ʻana i ka lāʻau no ka hōʻeha o ka puʻuwai naʻau e hoʻomaka me ka 2.5 mg i ka lā, a ma hope o nā lā he 3-5 ka nui i ka 5 mg. ʻO ka papa mālama mālama no kēia maʻi he 5-20 mg i kēlā me kēia lā.

No ka nephropathy maʻi maʻi, ua hōʻike ʻo Lisinopril e lawe i ka 10 mg i 20 mg o kēlā me kēia lā.

ʻO ka hoʻohana ʻana i ka maʻi myocardial akala e pili ana i ka hōʻeha maʻi a lawe ʻia e like me ka papa hana penei: ma ka lā mua - 5 mg, a laila like ka nui i hoʻokahi manawa i ka lā, a laila e pālua ʻia ka nui o ka lāʻau a lawe ʻia i hoʻokahi manawa i kēlā me kēia lā ʻelua, ʻo ka pau hope he 10 mg. i ka maka? i. Lisinopril, ʻike ʻia ka hoʻoholo ʻana i ka lōʻihi o ka mālama ʻana, no ka maʻi myocardial infarction e lawe ma kahi o 6 wiki.

ʻLoe a me ke kākele

I loko. I hoʻokahi lā lā, me ke ʻano o ka kau ʻana o ka meaʻai. Ma ka hihia o ka hypertension arterial, ʻike ʻia nā mea maʻi ʻaʻole i loaʻa nā lāʻau antihypertensive i hoʻokahiʻano 5 mg i hoʻokahi lā i ka lā, ʻo ka mālama mālamaʻana he 20 mg / lā. ʻO ka pae ʻauʻau uʻi ʻoi loa he 40 mg. Hoʻopilikia pinepine ka hopena piha ma hope o 2 a 4 mau pule mai ka hoʻomaka ʻana o ka mālama ʻana. Me ka hopena ʻole o ka lāʻau lapaʻau, hiki i ka hui pū ʻana o ka lāʻau me nā lāʻau lapaʻau antihypertensive ʻē aʻe.

Inā loaʻa i ka mea maʻi ka hoʻomaʻamaila mua me ka diuretics, a laila pono e hoʻokaʻawale ke kau i ka lāʻau lapaʻau i nā lā 2-3 ma mua o ka hoʻomaka ʻana o Lisinopril. Inā ʻaʻole kūpono kēia, a laila ʻaʻole pono ka hopena mua o ka lāʻau ma mua o 5 mg i ka lā. Ma kēia hihia, ma hope o ka lawe ʻana i ka ʻai mua, ʻōlelo ʻia ke nānā ʻana i nā hola he nui (ʻo ka hopena ʻoi loa ka hopena ma hope o ka 6 mau hola), ʻoiai e loaʻa ana kahi hōʻailona o ka neʻe koko.

I ka hiki ʻana o ka puʻuwai ulu - hoʻomaka me 2.5 mg hoʻokahi manawa, e ukali ʻia e ka hoʻonui pālua o 2.5 mg ma hope o 3 a 5 mau lā. ʻO ka 20 mg kiʻekiʻe loa i kēlā me kēia lā.

Acoc myocardial infarction (ma ke ʻano he hui hoʻohui i nā hola 24 mua me ka hemodynamics paʻa): i nā hola 24 mua - 5 mg mg, a laila 5 mg ma hope o ka lā 1, 10 mg ma hope o ʻelua mau lā a ma ka 10 mg hoʻokahi i ka lā. ʻO ka papa hana o ka lapaʻau ma kahi o 6 mau pule.

I ka poʻe elemakule, ʻike pinepine ʻia ka hopena hypotensive wā lōʻihi, kahi i pili ʻia me ka hoʻēmi ʻana o ka helu lisinopril excretion (ua ʻōlelo ʻia e hoʻomaka i ka mālama ʻana me ka 2.5 mg / lā).

I nā mea maʻi me ka hana pūnāwai paʻa ʻole kau ke kumu i kau ʻia ma luna o nā waiwai o QC.

70 - 31 (ml / min) (creatinine serum

Loaʻa ka hopena

Mai ka pūnaehana cardiovascular: ka hoʻohaʻahaʻa i ke koko, arrhythmias, ʻehaʻeha, ʻeha - orthostatic hypotension, tachycardia.

Mai ka ʻōnaehana hoʻonāukiuki: ʻeha, hōʻeha, luhi, luhi, kuuluu, nā māmina o nā ʻōpū o nā wāwae a me nā lehelehe, ka hopena - ka asthenia, ke kaumaha, ka hilahila, ka ʻōpū, ka luaʻi.

Mai ka pūnaehana hana ʻana: ninoa, luaʻi, ʻōpū, dyspepsia, hōʻemi i ka makemake, ʻokoʻa ka hoʻololi, ʻeha o ka ʻōpū, ka waha maloʻo.

Nā maʻi kūwaha: angioedema (edema kūloko o ka ʻili, ka ʻōpala subcutaneous a me / a me nā memu mucous i hui pū ʻia me urticaria a i ʻole ia,) ka ʻupihi o ka ʻili, ka haki.

Nā ʻili: ʻO ka umauma "hōʻemi, hoʻemi ʻia ka potency, kahi liʻiliʻi - ka maʻi, ka pupuhi (ka alelo, nā lehelehe, nā wāwae.)

Ke keu

ʻAʻole loaʻa nā ʻikepili maʻi ma luna o kahi helu lisinopril i kanaka.

Nā hōʻailona paha: haehae maʻi.

Lāʻau: e hāʻawi ʻia ka mea maʻi i kahi kūlana i luna me nā wāwae i hāpai ʻia, inā pono, e paʻi ʻia ka paʻakai intravenously, hana ʻia ka hemodialysis.

Hoʻopili pū me nā lāʻau ʻē aʻe

Alcohol, diuretics and other antihypertensive agents (blockers of α- and β-adrenergic receptors, calcium antagonists, etc.) potentiate the hypotensive effects of lisinopril.

ʻO nā lāʻau lapaʻau anti-inflammatory nonsteroidal, estrogens, adrenostimulants e hōʻemi i ka hopena hypotensive o ka lāʻau.

Me ka hoʻohana like ʻana me ka diuretics, ke emi ʻana o ke kaʻe o ka pā o potassium.

Ke hoʻohana nei i nā lāʻau lapaʻau e loaʻa ai ka lithium, hiki ke hoʻolōʻihi i ka hoʻoneʻe ʻana o ka lithium mai ke kino a, e like me ia, e hoʻonui ai i ka hopena o ka hopena o ka hopena. Pono e kiaʻi pono i ka pae o ka lithium i ke koko.

Hoʻohui me ka hoʻohana pū ʻana me nā beta-blockers, nā alapine palika pālua pale, diuretics a me nā lāʻau antihypertensive e hoʻonui i ka nui o ka hopena hypotensive.

ʻO nā Antacids a me colestyramine e hōʻemi i ka hoʻopili ʻana o ka lisinopril i ka gastrointestinal tract.

Nā hiʻohiʻona noi

Me ka akahele, pono e hoʻohana ʻia ʻo Lisinopril i nā mea maʻi me ka maʻi arterio coronary a i ʻole nā ​​maʻi cerebrovascular e pale ai i kahi kahe nui o ke kahe koko i loko o kēia mahele o nā maʻi.

Me ka mālama aka, ua kau ʻia ʻo Lisinopril i nā mea maʻi me ka hana ʻole o ka pilikia ma hope, ma hope o ka hōʻola ʻana o ka pēpē, me ka bilateral renal artery stenosis a i ʻole ka stenosis o hoʻokahi kōiwi keiki, ka maʻi o ka arterial, ʻokoʻa o ka laha cerebral, nā maʻi ʻōnaehana autoimmune, a me nā mea ʻē aʻe.

ʻO ka hypotension arential ʻaʻole he contraindication e hoʻohana hou aku i ka lāʻau ma hope o ka hoʻomau ʻana o ke kahe koko. Me ka hoʻohaʻahaʻa ʻana i ke koko, pono ia e hōʻemi i ka puʻupuʻu a kāpae paha i ka lawe ʻana iā Lisinopril a i kahi diuretic.

I ka poʻe maʻi me ka puʻuwai puʻuwai koʻikoʻi, hiki i ka hoʻohana ʻana o nā inhibitor ACE ke alakaʻi i ka hoʻololi hou ʻana i ka maʻi haneli. I kekahi mau mea maʻi me ka hypertension arterial, i hui pū ʻia me ka stenosis aralula paleka bilateral a i ʻole stenosis artery o hoʻokahi keiki, pae pae plasma o urea nitrogen a me ka creatinine e hoʻonui.

I nā maʻi me ka puʻuwai ulu ʻole me ka hoʻokahe koko wīwī a hōʻemi paha, e lawe iā Lisinopril e hōʻemi hou i loko o ke koko, akā ʻaʻole kēia ke kumu no ka pau ʻana o ka mālama ʻana.

I ka wā o ka hōʻiliʻili o ka hoʻohana ʻana i ka hoʻohana ʻana i nā lāʻau me ka hopena hypotensive no ka anesthesia, hiki i ka uku hoʻolimalima o renin. ʻO ka hypotension arterial ma muli o kēia mau hana i kāpae ʻia e ka hoʻonui nui ʻana o ka nui o ke koko kahe.

Hiki i ka hoʻomohala ʻana o ka hyperkalemia i nā mea maʻi me ka hiki ʻole o ka pale, diabetes mellitus, concomitant therapy me ka potassium-sparing diuretics (spironolactone, triamteren, amiloride) a me nā paʻakai paʻakai. Me ka hoʻohana pū ʻana o ka lisinopril me nā lāʻau lapa i luna, e nānā pinepine ʻia ka ʻike ʻana o ka pāhana i ka pāpapa ma loko o ka serum koko.

Me ka wikiwiki o ka lawe ʻana iā Lisinopril, ʻaʻohe wikiwiki a koʻikoʻi nui paha ka piʻi ʻana o ke koko i hoʻohālikelike ʻia me kona pae ma mua o ka lawe ʻana i ka lāʻau.

ʻO ke kūʻokoʻa a me ka palekana o Lisinopril ke kūʻokoʻa i ka makahiki o ka mea maʻi.

ʻŌpū a me ka lactation

Laminopril ua contraindicated i ka wā hāpai a me ka lactation (umauma maʻi).

ʻO ka hoʻohanaʻana i ka lāʻau lapaʻau i ka trimester II a me III o ke kōmala hiki ke alakaʻi i ka hōʻemi o ka nui o nā wai amniotic, nā hōʻailona o ka anuria, ka hypotension arterial a me ka pohō ʻana o nā iwi o ka ulupō.

Hoʻokomo i ka hiki ke alakaʻi i kahi kaʻa a hana pū me nā mīkini.

I ka wā o ka mālama ʻana, pono e pale i ka hana a me ka hana i nā hana ʻehaʻeha e koi ai i ka hoʻoulu ʻana a hoʻonui nui i ke ʻano o ka psychomotor ʻano, no ka mea ʻoi ʻia ka maʻi hakahaka, aemaise i ka hoʻomaka ʻana o ka ʻoihana.