Neurontin - nā ʻōlelo aʻoaʻo maʻamau no ka hoʻohana ʻana

Loaʻa ka lāʻau lapaʻau Neurontin i loko o kēlā mau ʻano:

• 100 mg, 300 mg a me 400 mg mau pālapa, ma waho o nā ʻōpū ke keʻokeʻo (100 mg), ka melemele kukui (300 mg) a i ʻole hina-ʻulaʻula (400 mg), i kapa ʻia he uliuli a hina paha (ka inoa o ka lāʻau lapaʻau, ka nui o nā mea ikaika a me "PD "), I loko o kahi papa keʻokeʻo a i ʻole keʻokeʻo keʻokeʻo.
• 600 mg a me 800 mg nā papa i keʻokeʻo keʻokeʻo, elliptical, ke kāʻei ʻeleʻele (600 mg) a i ʻole (800 mg).

Hoʻopili ʻia nā ʻiole ʻelua a me nā papa o 10 mau ʻāpana i nā pūʻulu blister. Hoʻonoho ʻia nā kāpala i nā pā kāleka o 2, 5 a i ʻole 10 mau ʻāpana.

Lapaʻau lāʻau

Gabapentin, he mea ikaika o Neurontin, hiki iā ia ke pale aku i ka hoʻokauhewa.

Ka like i ke ʻano o ka gabapentin e like me GABA, akā ʻaʻole ia i pili i kona metabolism. Kahi i ke kino, ua hui pū me ka alpun-2-beta subunits o nā kaila calcium-hilinaʻi kūwaho, e alualu i ka emi ʻana o ke kahe o nā hua. kalaiulaa hōʻemi i ka hopena o ka hoʻomohala ʻana ʻeha kaho ʻana.

ʻO ka Gabapentin e hōʻemi ana i ka nui o ka make o ka glutamate-hilinaʻi o nā sela nerve, hoʻonui i ka hoʻokumu ʻana o GABA, a hōʻemi i ka hoʻokuʻu ʻana o nā neurotransmitters o ka hui monoamine.

Lapaʻau lāʻau

ʻO ka pae bioavailability kiʻekiʻe loa he 60%, akā ua emi me ka hoʻonui ʻana i ka nui. Loaʻa ka ʻōpala plasma kiʻekiʻe loa ma hope o nā hola 2-3 ma hope o ka lawe ʻana i ka lāʻau lapaʻau. ʻAʻole pili loa ʻo Gabapentin i nā protein plasma (ʻaʻole iʻoi aku ma mua o 3%).

ʻO ka hapalua hapalua kahi e pili ana i nā hola 5-7, me kahi o ka hopena i lawe ʻia. Hoʻokuʻu ʻia ia i nā loli ʻokoʻa ma muli o ka hana o nā keiki.

Nā hōʻailona no ka hoʻohana ʻana

Hoʻouna ʻia ka hoʻohana ʻana o Neurontin i kēlā mau kūlana:

• ʻeha kaho ʻana (Hiki i nā lāʻau lapaʻau ke kau wale i nā poʻe he 18 a ʻoi aku nā makahiki).
• ʻāpana nahoa, ʻaʻohe o ka hele ʻana o ka generalization o ka lua (hiki ke lawe ʻia mai ka 3 mau makahiki he hoʻohui i ka mālama koʻikoʻi, mai 12 e like me ka monotherapy).

Nā hopena hopena

Hoʻopilikiaʻia ka hana me Neurontin i nā hopena ʻaoʻao mai ka hapa nui o nā ʻōpū a me nā ʻōnaehana o ke kino:

• hoʻoweliweli nenoai: kahi hana kīnā ʻole, he ʻano hūnāmanaʻoninini a utukaka waha maloʻo, ʻeha i loko o ka ʻōpū, ka maʻi dental, he hōʻemi a e hoʻonui paha i ka makemake,
• ʻano maʻamau: nāwaliwali, poʻomanaʻo, maʻiʻo-lepe maʻi, ʻeha ma nā ʻāpana like ʻole o ke kino, edema ma nā ʻāpana o ka lula a me ka helehelena, kaupaona ʻana,fivaho'ēmi i ka pale ʻana i nā maʻi maʻi viral,
• Pūnaehana saraf: lēʻaʻo ka memo, kamaʻilio, noʻonoʻo, gait, ʻike naʻau, hilahila, hiamoe, āhāhuʻe, hāpau, manaʻo ʻino, hele wāwae, ʻōpalahūʻike
• ea kalepa: ʻaʻano pōkolehopohopo e hoʻopilikia i nā maʻi o nā ʻōnaehana,
  ʻili: ʻili, ʻōwili. huu,
• ʻōnaehana cardiovascular: hoʻopihakoko koko kiʻekiʻe
• hematopoietic ʻōnaehana: leukopenia, wili, purpura,
• musculoskeletal ʻōnaehana: ʻeha i nā ʻōpū, hoʻopīpī, nā mākala, nā ʻāʻī o nā pilikia.

Neurontin, nā ʻōlelo no ka hoʻohana ʻana (Ke ʻano a me ke ʻano)

Lawe ʻia ka lāʻau lapaʻau me ka meaʻai a i kēlā me kēia manawa.

ʻO ka hoʻoponopono hoʻoponopono no ka maʻi neuropathic i nā pākeke.

• ka lā mua - 1 dosis o 300 mg o ka lāʻau,
• ka lā ʻelua - 2 mau kukuna o 300 mg,
• ke kolu o ka lā - 3 mau palena o 300 mg, i kekahi mau mea i kuhikuhi ʻia kēia kaila mai ka hoʻomaka ʻana,
• nā lā aʻe i kau aku nei - ke hilinaʻi ka hopena i ka hopena a me ke kūlana o ke kino - a waiho ʻia a loli iki a i ʻole e hoʻonui iki i ka nui (kiʻekiʻe loa - 3.6 g i kēlā lā).

ʻĀpana Māhele hopu i nā poʻe maʻi mai ka 12 mau makahiki, ua koho ʻia e like me kahi hoʻolālā i like me ka mea i hōʻike ʻia ma luna nei. I mea e pale ai i ka hana houhopu pono ia e hōʻoia i ka ʻaʻa o waena o nā lāʻau lapaʻau ma mua o 12 mau hola.

Nā hiʻohiʻona o ka mālama pōkole o nā hapa make i nā keiki 3-12 mau makahiki.

• luhi ka ʻia e like me ke kaumaha o ke keiki,
• mai ka lā mai kahi i koho ʻia ai he manawa ʻekolu manawa, me nā wā ʻaʻole iʻoi aʻe ma mua o 12 mau hola.
• huahelu mua - 10-15 mg / kg i kēlā me kēia lā,
• i loko o nā lā ʻekolu, e hoʻonui ʻia ka hopena mai ka hoʻomaka.
• ka hopena kaha: ma 3-5 mau makahiki - 40 mg / kg i ka lā, i ka makahiki 5-12 - 25-35 mg / kg / lā.

Kumuhana i loaʻa pilikia kūloheloheHiki ke hōʻemi ʻia ka dosage. Ke hoʻoholo nei, pono ke kau pono i ka māka kuhikuhi mea hana.

Ke keu

Hōʻike paha ke ʻano o kēlā mau ʻōuli he overdose.

• āhāhuʻe,
• kamaʻilio maopopo a mākaʻikaʻi paha.
• ʻike wua
• hiamoeʻoiai ma ka hoʻomohala ʻana hiamoe hiamoe,
• nā ninia.

I ka hihia o kahi overdose, pono pono nā hana hana e hoʻomaha ai i nā hōʻailona. Inā ʻaʻole hana maikaʻi kekahi kanaka, ʻoi aku hoʻi i nā hana koʻikoʻipilikia kūlohelohei hōʻike ʻia hemodialysis.

Hoʻohui

ʻO ke alakaʻi hui ʻana o Neurontin me nā lāʻau lapaʻau ʻē aʻe ʻaʻole e lilo i nā hopena koʻikoʻi o nā maʻi mai ke kino a i ʻole nā ​​loli i ka hana o ka lāʻau lapaʻau.

Inā ka mea e lawe i nā antacids e loaʻa i ka alumini a me ka magnesium, pono ke mālama i kahi ākea o nā liʻiliʻi he 2 ma waena o ka lawe ʻana i kēia lāʻau lapaʻau a me Neurontin. Inā ʻaʻole, hiki i ka bioavailability o gabapentin ke emi iho ma kahi o 20%.

Me ka hoʻohana pū ʻana me Moramona he hiki ke hoʻonui paha i ka paepae ʻeha, akā ʻaʻole i ʻike nui ka maʻi iki. Noho pinepine loa me kēia hui ʻana, inā e kūpaʻa ʻia ke ʻano Moramona a kiʻekiʻe ke neurontin, ʻike ʻia hiamoe. ^ E Ha yM. I kēia hihia, pono ia e hōʻemi i ke ʻano o kekahi o nā lāʻau.

Nā ʻōlelo kikoʻī

I ka hana ana i ka poʻe kahiko a me nā mea maʻi me nā mālamalama maikaʻi ʻole e pono ʻia e hōʻemi i ka dosage. Inā hiki i ka manawa like ka mea maʻi hemodialysis, pono e hoʻomaopopo ʻia me kēia kaʻina hana, ua hoʻopili maikaʻi ʻia ka gabapentin mai ka plasma, no laila, pono paha ka hoʻoponopono hoʻoponopono.

He mea pono ʻole e lawe i nā kaʻa a hana paha me nā mīkini e neʻe ai i ka wā o ka maʻi me Neurontin.

Hoʻopae i ka lāʻau lapaʻau a hōʻemi paha i ka make me ka lohi. ʻO ka hōʻemi iki ʻana i ka momona o ka hapa he nui nā kumuʻōpala, kaohuu, hopohopoʻeha ʻeha, ʻeha i nā ʻāpana like ʻole o ke kino, i kekahi manawa nahoa.

I ka wā hāpai a me ka lactation

ʻO ka ikehu palekana a me ka pono o ka hāpai ʻana a i ʻole a lawa ʻole ka nui o ka hoʻouka ʻana i hiki ai i kahi hopena hope loa. No laila, ua kuhikuhi wale ʻia aku i ka wā e loaʻa ai ka hopena kiʻekiʻe loa no ke olakino wahine.

I ka umauma waiū o nā wahine e mālama ʻia me Neurontin, loaʻa ka gabapentin. Pehea kona hopena ai i ka pēpē ʻaʻole ʻike ʻia, no laila e hoʻōki ka hānai.

Nā Hoʻohui

Wahi a nā ʻōlelo aʻo, ua kau ʻia ʻo Neurontin i nā keiki ma lalo o ʻekolu makahiki o kona mau makahiki. ʻAʻole pono ka lawe i ka lāʻau lapaʻau i nā mea maʻi me ka hypersensitivity i nā mea o ka lāʻau. Hōʻike ka loiloi o Neurontin e pono e lawe i kēia lāʻau lapaʻa me ka mālama aka ʻole o ka maʻi kumu ʻole.

ʻLoe a me ke kākele

E like me nā ʻōlelo i hiki ke hoʻohana ʻia, hiki ke hoʻohana ʻia ʻo Neurontin e pili ana i ka ʻai ʻana o ka meaʻai. Inā pono ʻoe e hoʻololi i ka dosage, a laila hoʻololi ʻia nā loli a pau. Me nā ʻeha neuropathic, ʻo ka hoʻomaka mua ʻana o Neurontin he 900 mg i kēlā me kēia lā, pono ia e māhele ʻia ʻekolu ʻekolu. Inā pono, hoʻonui pinepine ʻia ka lāʻau i ka 3.6 g i kēlā me kēia lā. Me nā ʻāpana kikowaena, like like ka pāʻana - mai 900 mg a 3.6 g i kēlā me kēia lā. Pili ka pili i nā mea maʻi a me nā keiki mai nā makahiki he ʻumikumamālua. ʻO ka maʻamau ka mahele i ka ʻekolu i ʻekolu manawa, akā ʻo ka palena ma waena o nā hopena o ka lāʻau e pono ai e ʻoi aku ma mua o nā hola he ʻumikumamālua e pale i nā hoʻopaʻi mau.

No nā keiki mai ʻekolu mau makahiki a me ʻumikūmālua, pono ka nui o ka make ma 10-15 mg no 1 kg o ka paona o ke kino i kēlā lā. Eia nō hoʻi, ʻoi aku ka lāʻau lapaʻau Neurontin ʻekolu mau manawa i ka lā, e hoʻonui iki ʻia ka pākēneka, i ka liʻiliʻi no nā lā ʻekolu.

ʻO nā mea maʻi me ka hala ʻole pono e hoʻohana i ka liʻiliʻi liʻiliʻi ma ka liʻiliʻi. Pono ka mālama ʻana e ka lāʻau lapaʻau.

Nā kikowaena o Neurontin

Kāhea ʻia nā ʻōmaka i nā lāʻau lapaʻau e like ka like me nā pūnaehana like. I kēia lā, ke hōʻike nei nā mea kikoʻī o Neurontin i loko o ka mākeke lāʻau o ka home.

• Gabagamma
• Gabapentin
• Hapentek
• Katena
• Convalis
• Lepsitin
• Tebantin
• Egipentin
• Eplirontin.

Hoʻohui nūhou

ʻO ka hoʻohana like ʻana o Neurontin me nā konane me ka konane me nā konane me ka magnesium e hoʻopili ʻia nei me ka hoʻēmi ʻana i ka bioavailability o gabapentin.

Ke hui pū ia me ka hydrocodone, ʻike liʻiliʻi i ka emi ʻana o ka make ma loko o kona Cmax (ka uʻi nui i loko o ke koko) a me AUC (ʻo ke ʻano holoʻokoʻa o ka lāʻau i ka plasma koko) e nānā ʻia i ka hoʻohālikelike ʻana me ka monotherapy hydrocodone.

Nā palapala ʻano:

pani ʻ -lelo ʻlelo

1 600 mg papa pili:

Mea waiwai: 600.0 mg gabapentin.

Nā mea hoʻoweliweli: Poloxamer 407 80.0 mg, copovidone 64.8 mg, kōpō palaoa 49.2 mg, magnesium stearate 6.0 mg, make a film opadra keʻokeʻo YS-1-18111 24.0 mg talc 17.4 mg, hyprolose 6.6 mg, wax herbal (candelila) 0.6 mg.

1 papa o 800 mg mau:

Mea waiwai: 800.0 mg gabapentin.

Nā mea hoʻoweliweli: Poloxamer 407 106.7 mg, copovidone 86.4 mg, kōpana

palaoa 65.6 mg, magnesium stearate 8.0 mg, kiʻiʻoniʻoniʻili: opadra keʻokeʻo YS-I-18111 32.0 mg talc 23.2 mg, hyprolose 8,8 mg, wax herbal (candelila) 0.8 mg.

Wahi a 600 mg: nā kelepona i ulana ʻia a elliptical keʻokeʻo, i kahakaha ʻia me "NT" a me "16". notch ma waena ka kahakaha ma kekahi ʻaoʻao a notch ma kekahi ʻaoʻao.

Wahi a 800 mg: nā kelepona i ulana ʻia a elliptical keʻokeʻo, i kahakaha ʻia me "NT" a me "26". notch ma waena ka kahakaha ma kekahi ʻaoʻao a notch ma kekahi ʻaoʻao.

ʻO nā waiwai Pharmacological

Lapaʻau lāʻau

Hoʻopili maʻalahi ʻo Gabapentin i ka lolo o ka lolo a pale i ka hoʻomohala ʻana o ka make i nā ʻano holoholona like ʻole o ka epilepsy. ʻAʻohe mea a Gabapentin e pili ai i nā mea hoʻokipa GABA_A (gamma-aminobutyric acid) a me GABA a ʻaʻole i hoʻopā i ka metabolism o GABA. ʻAʻole nakipili ʻo Gabapentin i nā receptors o nā neurotransmitters e kū aʻe i loko o ka lolo a ʻaʻole e hoʻopilikia i nā kanika sodium.

He pilina nui ka Gabapentin a nakinaki aku i ka subunit α-2-δ (alpha-2-delta) subunit o ke kanalā kōpaona e hilinaʻi kūwaho a ua manaʻo ʻia ʻo ka hui o gabapentin me ka subunit α-2-δ pili i ka hana o ka hopena anticonvulsant i nā holoholona. Ke kaʻi nei i kahi pūʻulu nui o nā molekele waiwai no kēia lāʻau lapaʻau, hōʻike ʻia ia i ka subunit a28 wale nō kāna pahuhopu. Hōʻike nā hopena i loaʻa i loko o kekahi mau helu preclinical e hiki ke ʻike ʻia ka hana o ka lāʻau lapaʻau ma ka gabapentin ma o ka hoʻopaʻa ʻana i ka subunit α-2-inhib ma ka pale ʻana i ka hoʻokuʻu ʻana o ka neurotransmitters excitatory ma kekahi mau wahi o ka papa hana waena. Kēia mau hana i lalo i ka hopena anticonvulsant o ka gabapentin. ʻO ka pilina o kēia mau hana o ka hana o ka gabapentin no kona mau hopena anticonvulsant i nā kānaka e pono ke hoʻokū ʻia. Hōʻa ʻia ka hopena o ka gabapentin i loko o kekahi mau noi preclinical i loko o nā holoholona holoholona o ka ʻeha. Manaʻo ʻia e alakaʻi i ka hoʻopili kūikawā o ka gabapentin i ka subunit α-2-δ i nā hopena like ʻole e kū ai ke kuleana o ka analgesic i nā hiʻohiʻona holoholona. Hiki i ka hopena analgesic o ka gabapentin ke kau i ka pae o ka spinal cord, me ke kaʻe o nā kikowaena kiʻekiʻe o nā lolo ma o nā hōʻuluʻulu ʻana me nā ala e iho ana e hoʻopaʻa ana i ka lawe ʻia ʻana o ka maʻi impulses. ʻAʻole maopopo ka ʻike nui o kēia mau wahi gabapentin i hōʻike ʻia i nā ʻimi preclinical.

He mākaukau me ka palekana

Ma ke ʻāpana o ka hoʻokolohua lapaʻau e pili ana i ka hoʻokaʻawale o nā ʻekahi hapa i nā keiki i nā makahiki 3 a hiki i ka 12 mau makahiki, ka ʻike ʻana i ka quantitative, akā hiki ke kūleʻa a ʻo nā helu kūloko. Ka hoʻākāka hou ʻana i ka pinepine o ka pane ʻana i ka therapy ma muli o ka makahiki (i ka wā e noʻonoʻo ai i ka makahiki he ʻano loli mau a i ʻole i wehe ʻia nā makahiki he ʻelua mau makahiki: 3-5 mau makahiki a me 6-12 mau makahiki) ʻaʻole i hōʻike i kahi hopena koʻikoʻi o ka makahiki ma ka hopena o ka hopena. Hōʻike ʻia nā hopena o kēia noiʻi hou aʻe i ka papa ma lalo nei.

* ʻO ka "loli" maikaʻi "hoʻololi" (MITT) i wehewehe ʻia ka nui o nā maʻi āpau i hoʻololi ʻia i ka hui noiʻi noiʻi ʻana a me nā mea hoʻohālikelike loiloi e loiloi ʻia no nā manawa 28 o ka manawa mua a me ka lua o ka lua.

Lapaʻau lāʻau

Ma hope o ka lawelawe waha, ua loaʻa ka nui o ka gabapentin i ka plasma i loko o nā hola 2-3. ʻO ka bioavailability o gabapentin e hoʻohiki me ka hoʻonui nui i ka nui. Loaʻa ka bioavailability pololei i ka wā e lawe ai i nā kapika he 300 mg kahi ma kahi o 60%. ʻO nā meaʻai, me nā mea i loaʻa ka momona momona, ʻaʻole i loaʻa ka hopena koʻikoʻi i nā pharmacokinetics o gabapentin. ʻAʻole loli i nā pharmacokinetics o gabapentin me ka hoʻokele hou ʻana o ka lāʻau. ʻOiai ka mea ma ka hoʻāʻo ʻana i ka lāʻau lapaʻau, ua ʻokoʻa ka neʻe o ka gabapentin i ka plasma i loko o ka awelika o 2-20 ,g / ml, ʻaʻole nō ia i wānana i ka hopena a i ʻole ka palekana o ka lāʻau. Ke hōʻike ʻia nei nā hiʻohiʻona pharmacokinetics i ka papa ʻaina.

Pākaukau.

Ka awelika haʻawina (CV,%) pharmacokinetics o gabapentin i ke kūlikeila me nā nui helu me nā pawahe ʻewalu o nā hola he ʻewalu.

ʻAʻole nakipili ʻo Gabapentin i nā protein protein, a ʻo kona puʻupu māhele e 57.7 lita. I ka poʻe maʻi me ka epilepsy, ʻo ka ʻike o ka gabapentin i ka cerebrospinal fluid (CSF) ma kahi o 20% o ka liʻiliʻi o ka hoʻokūkū plasma kūlike. Hoʻokomo ʻo Gabapentin i ka waiū waiū o nā wahine hānai.

ʻAʻohe ʻikepili i ka metabolism o gabapentin i ke kino o ke kanaka. ʻAʻole ʻo Gabapentin e hoʻonāukiuki i ka ʻaina o nā maʻi o ka pōpoki manuahi nonohina pili i ka metabolism lāʻau.

Hoʻopili ʻia ʻo Gabapentin i ke hoʻololi ʻole ʻia e ka renal excretion. ʻO ka hapalua hapalua o gabapentin he kūʻokoʻa ma kahi o ka pau i lawe ʻia a me nā waiwaena 5 a 7 mau hola.

I ka poʻeʻelemakule a me nā mea maʻi me nā hana renal impaired, hoʻopau ʻia ke kīpē o ka gabapentin mai i ka plasma. ʻO ka hoʻopau ʻana, ka hana ʻana i ka plasma a me ka hoʻomaʻemaʻe wehe o ka gabapentin i hoʻohālikelike mau ia i ka hoʻomaʻamaʻa creatinine.

Hoʻokuʻu ʻia ʻo Gabapentin mai ka plasma e nā hemodialysis. ʻO nā mea maʻi me ka hana renal impaired a i ʻole nā ​​mea ma ka hemodialysis e ʻōlelo e hoʻoponopono i ka hopena o ka lāʻau (e ʻike i ka ʻāpana "Dosage and Administration").

Ua aʻo ʻia nā pharmacokinetics o gabapentin i nā keiki i 50 mau mea ola olakino ʻoi aku ka makahiki 1 a hiki i ka 12 mau makahiki. Ma keʻano holoʻokoʻa, ʻo ka neʻe o ka gabapentin i ka plasma o nā keiki ma mua o 5 mau makahiki he mau like ia me nā mea pākeke ke hoʻohana ʻana i ka lāʻau lapaʻau ma kahi o ka nui e pili ana i ka helu ʻana o ka paona kino o mg / kg.

Ma ka noiʻi o pharmacokinetics i nā keiki olakino 24 a keu 1 a 48 mau mahina, ʻo ka nui o nā kiko o ka lāʻau (AUC) ma kahi o 30% haʻahaʻa, C_mah- ka hoʻomaʻamaʻa haʻahaʻa a kiʻekiʻe a kiʻekiʻe paha ke kikoʻī o ke koʻikoʻi o ke kino a hoʻohālikelike ʻia me nā ʻike i paʻi ʻia ma nā kinetics o ka lāʻau i nā keiki ma mua o 5 mau makahiki.

Hoʻonohonoho / kaua lihilihi o nā ʻalemai pharmacokinetics

Hoʻololi ka bioavailability o gabapentin me ka hoʻonui nui ʻana i ka wai, ka mea e hoʻopili ai i ka laina o ka lula o pharmacokinetic o nā hiʻohiʻona, ʻo ia hoʻi ka indexation bioavailability (F), no ka laʻana, Ae%, CL / F, Vd / F. Hoʻokuʻu ʻia ka pharmacokinetics (nā kāʻei ʻikepili ʻaʻole me F, e like me CLr a me T1 / 2) i mea maikaʻi ʻia e ka hoʻohālike laina.

He kūlike nā paʻila plasma o ka hoʻokele ʻana o ka gabapentin e pili ana i ka ʻikepili kinetics me kahi pākahi.

Hoʻohana i ka wā hāpai a i ka wā o ka umauma

ʻAʻohe ʻikepili i ka hoʻohana ʻana o ka lāʻau lapaʻau i nā wahine hāpai.

ʻO ka hopena maʻamau e pili ana i ka lāʻau epilepsy a me nā lāʻau antiepileptic

Hōʻalo ka hānau ʻana i nā keiki me nā anomalen congenital i loko o nā makuahine i mālama ʻia me nā anticonvulsant e hoʻonui ʻia i 2-3 mau manawa. ʻO ka pinepine pinepine ka holoi ʻana i ka lehelehe ma luna a me ka palate, nā kuhihewa o ka ʻōnaehana cardiovascular a me nā hemahema o ka neural tube. Eia kekahi, lawe aku i kekahi mau anticonvulsants e pili me ka nui aʻe o ka nui o ka hana ʻino ma mua o ka hihia o ka monotherapy. No laila, inā hiki, pono e hoʻohana kekahi o nā anticonvulsants. ʻO nā wahine o ka wā hānau keiki, a me nā wahine a pau paha i hāpai ʻia, pono ke kūkākūkā me kahi loea. Inā hoʻolālā ka wahine i kahi hapai, pono e loiloi hou ʻia ka pono no ka maʻi anticonvulsant therapy. I ka manawa like, ʻaʻole pono e hoʻopau koke i ka anticonvulsants, no ka mea hiki i kēia ke alakaʻi i ka hoʻomaka hou ʻana o nā mea hopu me nā hopena koʻikoʻi no ka makuahine a me ke keiki. I nā hihia pinepine, i nā keiki i loaʻa ai ka mau makuahine i ka epilepsy, ua nānā ʻia ka lohi ʻana. Eia naʻe, hiki ʻole ke hoʻoholo inā pili paha ka lohi ʻana i ka hoʻomohala pili i nā genetic a i ʻole nā ​​pili pili kino, nā maʻi ʻono, a i ʻole ka maʻi anticonvulsant.

Hoʻopilikia ka Gabapentin

I nā hoʻokolohua holoholona, ​​ua hōʻike ʻia ka huikala o ka lāʻau i ka fetus. E pili ana i ka pilikia kūpono, ʻaʻohe ʻikepili o nā kānaka. No laila, pili ʻo gabapentin i ka wā hapai inā inā pono ka manaʻo i ka makuahine ke ʻāpono i ka hiki ke hoʻopili i ka wahine.

ʻAʻole hiki ke hana i kahi manaʻo ʻoi loa e pili ana i ka pilina o gabapentin me ka piʻi nui o ka nui o nā anomenies congenital i ka wā e hoʻohana ai i ka wā hapai ma ke ʻano o ka epilepsy ponoʻī a me ka hoʻohana like ʻana o nā lāʻau antiepileptic i kēlā me kēia hihia hoʻopaʻa.

Hoʻopili ʻia ʻo Gabapentin ma ka umauma umauma, ʻaʻole ʻike ʻia kona hopena i ka pēpē hānai. No laila, i ka wā o ka hoʻoulu ʻana, e kauoha ʻia ʻo Neurontin wale nō inā he pōmaikaʻi ka nui o ka makuahine i ka hopena o ka pēpē.

ʻAʻole mālama nā aʻo holoholona i nā hopena o ka gabapentin e hānai i ka ulu.

ʻLoe a me ke kākele

No nā hōʻailona āpau, hōʻike ʻia ke ʻano hoʻohālikelike o ka wai hoʻomohala i ka lāʻau lapaʻau i ka papa helu 1. Hāʻawi ʻia kēia hana no ka poʻe maʻi a me nā ʻōpio ʻo nā makahiki he 12 a keu aku. Hōʻike ʻia ke kumuhana titration no nā keiki ma lalo o nā makahiki he 12 i lalo o kahi huaʻōlelo kaʻawale.

Papa Helu 1 1 Kiʻi o ka titration o ka hopena o ka lāʻau lapaʻau i ka hoʻomaka ʻana o ka maʻi

300 mg hoʻokahi i kēlā me kēia lā

300 mg 2 mau manawa i kahi lā

300 mg 3 mau manawa i kahi lā

Ke kuhi nei i nā lāʻau gabapentin

Wahi a ka hoʻomaʻamaʻa hou ʻana i kēia manawa, inā pono e hoʻopau i ke ʻano gabapentin, pono e hana iki ia i ka lōʻihi o ka manawa he hoʻokahi, ma kahi o nā hōʻailona.

Me ka epilepsy, mālama pinepine ʻia ka mālama lōʻihi. Hoʻoholo ʻia ka nui o ka lāʻau lapaʻau e ka mea hele i ke kauka e hilinaʻi ana i ka hoʻomanawanui ʻē aʻe a me ka hana pono o ka lāʻau.

Nā pākeke a me nā keiki ma mua o 12

i nā haʻawina loea, mai ka hopena kūpono mai 900 a 3600 mg / lā. Hiki ke hoʻomaka ka Therapy e like me ka hoʻolālā i hōʻike ʻia ma luna o ka papaʻaina 1 a i ʻole me kahi dosis o 300 mg 3 mau manawa i ka lā ma ka lā mua. Ma hope iho, e pili ana i ka pane o ka mea maʻi i ka hoʻomohala a me ka ʻoluʻolu o ka lāʻau lapaʻau, hiki ke hoʻonui ʻia ka lāʻau lapaʻau ma ka 300 mg / lā i kēlā me kēia lā 2-3, a hiki i ka 3600 mg / lā. I kekahi mau mea maʻi, he kūpono paha ka hoʻonui ʻana iho e pae. ʻO ka manawa haʻahaʻa e hiki ai iā ʻoe ke hoʻonui i ka lāʻau i ka 1800 mg / lā he 1 pule, 2400 mg / lā - 2 mau pule, a hiki i ka nui o nā lā he nui o 3600 mg / lā, liʻiliʻi ʻia 3 mau pule e koi ʻia. Ua hōʻike ka Diltelnyh i nā hoʻokolohua olakino maikaʻi e hiki ke hoʻopaʻa i ka lāʻau i loko o nā inapo a hiki i ka 4800 mg / lā. Pono ka ʻāpana kūhelu i kēlā me kēia lā i ʻekolu. ʻO ka lōʻihi loa ma waena o nā pona me ka hapa ʻekolu o nā lāʻau e pono ai e hānai i nā hola 12 i mea e pale ai i ka hoʻomaha hou ʻana i nā waiwai.

Mua keiki i ka makahiki 3-12: ua hoʻohālikelike ʻia ka hopena mua o ka lāʻau mai ka 10 a hiki i ka 15 mg / kg / lā, i kuhikuhi ʻia ma nā kaulike like he 3 mau manawa i ka lā a ua hoʻonui ʻia ma ka hana i loko o 3 mau lā. ʻO ka hopena e pili ana i ka gabapentin i nā keiki he 5 mau makahiki a ʻoi aku ka 25-35 mg / kg / lā ma nā kaulike like ʻole ma 3 mau puʻupuʻu i hoʻokaʻawale ʻia. ʻO ka hopena e pili ana i ka gabapentin i nā keiki he 3 a hiki i 5 mau makahiki he 40 mg / kg / lā ma nā kaulike like ʻole ma 3 mau puʻupuʻu i hoʻokaʻawale ʻia. Hoʻomaopopo ka maikaʻi o ka lāʻau lapaʻau a hiki i 50 mg / kg / lā me ka hoʻohana lōʻihi. Pono ka lōʻihi loa ma waena o nā pona o ka lāʻau lapaʻau ma mua o 12 mau hola e pale ai i ke ʻano hou ʻana o nā waiwai.

ʻAʻohe pono e kāohi i ka ʻike ʻana i ka gabapentin i ka plasma. Hiki ke hoʻohana pū i ka hui me nā anticonvulsants ʻē aʻe me ka ʻole e hoʻokomo i nā loli i kona neʻe ʻana i ka plasma a i ʻole ka hoʻoliina ʻana o nā anticonvulsants o serum.

Hiki ke hoʻomaka ka Therapy e like me ka hoʻolālā i hōʻike ʻia ma luna o ka papa helu 1. ʻO kahi ala hou aʻe o ka hōʻaole - ʻo ka inua mua ʻo 900 mg / lā i ʻekolu mau puʻupu i hoʻokaʻawale. Ma hope iho, e pili ana i ka pane o ka mea maʻi i ka hoʻomohala a me ka ʻoluʻolu o ka lāʻau lapaʻau, hiki ke hoʻonui ʻia ka lāʻau lapaʻau ma ka 300 mg / lā i kēlā me kēia lā 2-3, a hiki i ka 3600 mg / lā. I kekahi mau mea maʻi, he kūpono paha ka hoʻonui ʻana iho e pae. ʻO ka manawa haʻahaʻa e hiki ai iā ʻoe ke hoʻonui i ka lāʻau i ka 1800 mg / lā he 1 pule, 2400 mg / lā - 2 mau pule, a hiki i ka nui o nā lā he nui o 3600 mg / lā, liʻiliʻi ʻia 3 mau pule e koi ʻia.

I ka loaʻa ʻana o ka mamae neuropathic peripheral, i nā kūlana e like me ka ʻano hana hōʻeha o ka maʻi neuropathy diabetic a me ka postherpetic neuralgia, ka hopena a me ka palekana o ka lāʻau lapaʻau no kahi manawa lōʻihi ma mua o 5 mau mahina ʻaʻole i aʻo ʻia i nā haʻawina ma ke ʻano. Inā pono ka mea hoʻomau e hoʻomau i ka mālama ʻana i ka mamae neuropathic peripheral i ʻoi aku ma mua o 5 mau malama, pono e loiloi ke kauka hele i ke kūlana o ka mea maʻi a hoʻoholo i ka pono o ka lāʻau hou.

No nā ʻōlelo aʻo

I nā maʻi i nā maʻi koʻikoʻi, no ka laʻana, ma ka hopena o ka hoʻemi ʻana o ke kino kino, ma hope o ka hoʻololi ʻana i ke kino, a me nā mea ʻē aʻe, me ke ʻano nui, e hoʻolōʻihi ʻia ka nui o ka make ʻana, me ka hoʻohana ʻana i nā ʻaina haʻahaʻa a i ʻole ka lōʻihi o ka wā ma mua o ka hoʻonui ʻana i ka nui.

Hoʻohana i nā mea maʻi maʻi (ma mua o 65 mau makahiki)

Ma muli o ka emi ʻana o nā makahiki i ka hana o ka renal, pono paha i nā poʻe maʻi kahiko ke hoʻoponopono ʻia (no ka ʻike hou aku e ʻike i ka papa 2). ʻO ka ʻehaʻawa, ke edema peripheral a me ka asthenia i nā maʻi maʻi e ulu pinepine pinepine.

Hoʻohana i ka poʻe maʻi me ka hiki ʻole o ka pale

ʻO ka poʻe maʻi me ka hana renal maʻi ʻole a i ʻole a i ʻole i nā mea maʻi ma ka hemodialysis e kuhikuhi ʻia e hōʻemi i ka nui o ka gabapentin e like me ka papa helu 2.

Papa helu 2. Ka make ʻana o ka gabapentin i nā maʻi maʻi makua ma muli o ka hanaʻōpala