Nā papa Hypoglycemic Glybomet: nā ʻōlelo no ka hoʻohana ʻana

Hana ʻia kēia lāʻau lapaʻau hypoglycemic ma ke ʻano o ka dragees a puni ka pā uhi. Aia i kēlā me kēia papa Glibomet ka hoʻopiha ʻana i ka metformin hydrochloride a me ka glibenclamide, e hana nei he mau lālā ikaika. ʻO nā mea kōkua e mālama ai i ka gelatin, MCC, ua pale ʻia i ka silica ʻano, ka pauka palaoa, magnesium stearate, glycerin, diethyl phthalate, cellulose acetate phthalate a me talc.

No ka lawe ʻana i ka lāʻau lapaʻau hypoglycemic Glybomet, ʻo nā ʻōlelo aʻo e hoʻohana ka ʻānō inā he monotherapy me nā lāʻau lapaʻau a i ʻole ka hōʻola ʻana i ka maʻi ʻaina ʻole maikaʻi loa no ka mālama ʻana i ke ʻano o ka diabetes non-2 mellitus. Eia kekahi, ua hāʻawi ka mea hana i ke kuhikuhi ʻana i kēia mau papa me ka hoʻohaʻahaʻa ʻana i ka sulfonylureas ma muli o kā lākou hoʻohana lōʻihi ʻana.

ʻO nā hopena no ka maikaʻi ʻole a me nā hopena paha, hiki ke hōʻike ʻia ke ʻano o nā hiʻohiʻona ma ka lawe ʻana i nā papa Glybomet, ka hōʻeuʻeu o ka hypoglycemia, jaundice cholestatic a i ʻole hepatitis e hōʻike mua ma mua. Eia kekahi, hiki i kekahi poʻe ke hoʻohana i kēia mea hana e ʻike i nā kūlana e like me ka luaʻi, ke poʻo, ka nāwaliwali, kaʻeha sensory, nā hives, paresis, nā ʻeha lipoli, megaloblastic a hemolytic anemia, ʻeha pūpū.

Glybomet - kaʻili

ʻO ka hui pū i kēlā me kēia papa o ka pūnaehana ikaika ʻelua - metformin hydrochloride (400 mg) a me glibenclamide (2.5 mg) hiki i ka hiki ke kāohi wale i ka glycemia, akā ke hōʻemi nei hoʻi i ka maʻi o kēia mau ʻāpana. Inā ua hoʻohana ʻia kēlā me kēia nona i ka monotherapy, e kiʻekiʻe loa ka nui o ka nui.

Loaʻa ia i ka pula a me nā mea loaʻa i ke ʻano o ka cellulose, starch corn, colloidal silicon dioxide, gelatin, glycerin, talc, magnesium stearate, acetylphthalyl cellulose, diethyl phthalate.

Nā hiʻohiʻona Pharmacological

ʻO kekahi o nā mea hana ikaika, ka glibenclamide, kahi lāʻau lapaʻau hou o ka papa o ka sulfonylurea, e waiho nei i ka papa inoa o nā mea ola nui me ka pancreatic a me nā mana o ka pancreatic.

ʻAʻole ia e hoʻoulu wale i ka hana o ka pancreas holoʻokoʻa, akā e hoʻonui pū i ka hana o ka insulin endogenous. Kūkulu ka hana o kā lākou hana i ka pale o ka pancreatic β-cells i hoʻopau ʻia e ka glucose hoʻonāukiuki, e hoʻoholo ai i ka holomua o ka maʻi diabetes, a me ka hoʻoulu ʻana i ka naʻau o ka insulin o nā cell target.

ʻO ka lawe ʻana i Glibomet i kahi kuʻikahi me ka mana glycemic e hoʻomaikaʻi i ka hana lipid metabolism a hoʻemi i ka hopena o nā koko koko. Hoʻonui ka hana o ka insulin, a me ia mea ʻo ka unuhi ʻana o ka glucose e nā io ʻoi a me nā ʻāʻī. Hoʻohana ka lāʻau lapaʻau i ka lua o ka hana o ka hana hana i ka insulin.

Aia ka Metformin no ka biguanides - kahi papa o nā mea hoʻonāukiuki e hōʻemi ana i ka insensitivity o nā selela makapō i kā lākou iho ponoʻī. ʻO ka hoʻihoʻi ʻana i ka naʻauao, ʻaʻole iʻoi aku ka mea nui ma mua o ka hoʻomaikaʻi ʻana i ka mea huna o ka hormone, no ka mea me ka maʻi diabetes type 2, hoʻohālikelike ka pancreas iā ia me ka keu.

Hoʻonui ka Metformin i ka pilina o nā mea paʻi a me ka insulin, hoʻonui i ka hoʻoponopono o ka postreceptor o ka hormone. I ka make ʻole o ka insulin i ka kahe koko, ʻaʻole i hōʻike ʻia ka hopena therapeutic.

Loaʻa i nā mea waiwai ka Metformin:

Ke hoʻolōʻihi nei i ka komoʻana o nā glucose e nā paia ʻeha a kōkua i kona hoʻohana ʻana i nā ʻiʻo.
Ke hōʻike nei i ka gluconeogenesis,
Mālama i ka b-cell mai ka wikiwiki apoptosis,
Hoʻēmi i ka pilikia o kekahi ʻano o ka waikawa a me nā maʻi koʻikoʻi,
Hoʻomaikaʻi i ka microcirculation o nā lolo, ka hana endothelial a me ka momona o ka momona (e hoʻemi ana i ke kāʻei o ka "hōʻeha" kolesterol a me ka triglycerol i ke koko),
Mālama i ka hoʻolilo kaupaona - kahi kūlana koʻikoʻi no ka mālama glycemic maikaʻi i ka ʻano 2 DS,
Hoʻemi i ka hoʻokaʻawale koko a me ke kaumaha o ka oxidative,
Loaʻa iā ia kahi hopena fibrinolytic ma ka lawe ʻana i ka mea hoʻopihapena plasminogen kiko,
Mālama i nā ʻōnaehana oncological (ma ka laulā, hoʻonui ka maʻi diabetes i ka nui o ka oncology ma ke 40%),
Hoʻemi i ka pilikia o ka make mai nā hanana cardiovascular.

Ua nānā ʻia kahi hōʻike hoʻohālikelike o ka maʻi maʻi maʻi 5800 me ke ʻano maʻi type 2 i Kina. Ua loaʻa nā mea komo i ka hoʻokalakupua me ka metformin i hui pū me nā loli ʻano. I ka hui hoʻomalu, ua hoʻoponopono nā mea hana hou i ko lākou ola. No 63 mau mahina, ma ka hui mua, he 7.5 mau kānaka ma kahi 1000 o nā kānaka / mau makahiki, ma ka lua - no 45 mau mahina, e like me 11 nā kānaka.

Hoʻomaka ka lāʻau lapaʻau e hana i ʻelua mau hola ma hope o ke komo ʻana i ka esophagus, ua hoʻolālā ʻia kona pono no nā hola 12. ʻAʻole hoʻokomo ʻo Metformin i kahi hoʻoweliweli hypoglycemic. ʻO ka lāʻau lapaʻau me kahi waihona hōʻike ʻoi nui, ua hala i kahi hōʻike paʻa mau o ka manawa a koi i ka maʻi maʻi i nā manawa a pau o ka hoʻonui ʻana i ka ʻoihana.

I kēia mau lā, hāʻawi ke kūʻai aku i ka lāʻau lapaʻau i nā papa he 10 o nā lāʻau antidiabetic, akāʻo ka metformin ka mea kaulana loa no ka mālama ʻana i ka maʻi type 2 i kēlā me kēia manawa o ka maʻi.

ʻO ka hui pūʻohu synergistic o nā mea hana ʻelua o Glibomet ka hopena paʻakikī i ke kino.

Ka hopena pancreatic - ʻo ka lāʻau lapaʻau e hōʻemi i ka "makapō" o nā cell, hoʻoulu i ka ʻōheu ʻana o kāna iho i ka insulin, a mālama i nā ʻoihana b.
Hoʻopilikia ka hopena o ka pancreatic - ka maʻi biagudin e hoʻopili pinepine i ka huina a me ka momona momona, hōʻemi i ka gluconeogenesis, e hoʻonui i ka pākēneka o ka holohū glucose piha.

ʻO ka palena kiʻekiʻe o nā kikoo ikaika o nā mea ikaika e hiki ke hoʻoponopono nui i ka nui o ka lāʻau. No nā b-cell, he mea nui loa ka hoʻoulu ʻana o ka sparing: hoʻonui i ka palekana i ka lāʻau lapaʻau, hōʻemi i ka hōʻemi ʻana o ka hana hana, a hoʻemi i ka hopena o nā hopena like.

Hiki i nā maʻi Pharmacokinetic

Hoʻopili ʻia ʻo Glybenclamide mai ka gastrointestinal tract a hoʻoiho ʻia a hoʻokau maikaʻi loa ʻia - ma ka 84%, hiki ke nānā ʻia ka hopena nui o ka lāʻau lapaʻau ma hope o 1-2 mau hola. Hoʻopili ka māhele i nā ʻōnaehana koko ma 97%.

Hoʻolaha ka metabolible Glibenclamide i loko o ke akea, kahi e hoʻohuli ʻia i loko o nā mea i hana ʻole ai ka metabolites. ʻO ka hapalua o nā mea i hoʻopau ʻia e hele i nā ʻōpū, ʻo kekahi ʻaoʻao ma o nā kumu o ka bile. ʻO ka hapalua hapalua ke ola i nā hola 10.

Hoʻopau piha ka Metformin i ka ʻōnaehana kūwili, lawe koke ʻia i nā ʻāpana a me nā io, ʻaʻole paʻa i nā palekō i ke koko a pau. ʻO ka bioavailability o ka māhele mai 50-60%.

Ka laulā maʻamau, ka lōʻihi o ka minamina o nā mea o ke ʻano o ke ʻano i loko o ke koko e loaʻa i hoʻokahi hola a i ʻole ʻelua ma hope o ka lawe ʻana i ka paila.

Nā hōʻailona no ka mālama ʻana me Glybomet

Ua hōʻike ʻia nā ʻōkuhi koʻikoʻi e kuhikuhi ʻia ka lāʻau lapaʻau no ka maʻi maʻamau o ka lā 2, me ka maʻi diabetes-hilinaʻi, inā he meaʻai kūikawā, ka hana kino dosed a me nā hopena hypoglycemic hāmama ʻaʻole i hāʻawi i ka hopena i hoʻolālā ʻia.

He nui nā hopena lapaʻau he nui inā pane ʻole ke kino i ka lāʻau lapaʻau, hoʻololi lākou i ka algorithm lapaʻau e ka kuhikuhi ʻana iā Glibomet i nā papa.

Ka mea, ua hoʻonoho ʻia o ka hopena

Mai ka hopena o ka lāʻau lapaʻau ka hopena paʻakikī o ka pilikia, ʻaʻole ia he mea kupanaha no ka loaʻa ʻana o nā mea paʻa i ka hoʻokomo.

Hiki i ka lāʻau lapaʻau ke pilikia:

Me ka maʻi maʻi maʻi gestational,
Inā loaʻa ka maʻi i ka maʻi kiʻekiʻe o nā mea o nā ʻano,
ʻO ka maʻi diabetes me ke ʻano maʻi mua ʻole,
Me ka maʻi maʻi coma a me nā palena palena, Pehea e lawe ai iā Glibomet

Ke kau nei nā kau palena iā Glibomet:

Me nā pathologies o ka nui o ka glandula,
Inā loaʻa ka maʻi maʻi,
I ka manawa o ka mōʻaukala o ka hypofunction o ka cortex cuitex a me nā kelepa adrenal.

Hoʻoholo ʻia ka dosage e ka endocrinologist e like me nā makahiki a me nā mea maʻi a nā maʻi, akā ua hōʻike ka mea hana e hoʻomaka me ʻelua papa i kēlā me kēia lā, hopu mau i ka lāʻau. ʻO ka nui loa o ka lāʻau lapaʻau ka 2 g / lā. Hoʻomaopopo ʻia e ka hāʻawi ʻana i ka hoʻokipa i nā manawa maʻamau. Inā ʻaʻole i loaʻa kēia kālā i ka hopena i manaʻo ʻia, ʻōlelo ʻia ka hoʻomaʻemaʻe ʻana me ka hoʻohui ʻana i nā lāʻau ikaika ikaika.

Nā hopena ʻaoʻao a me ka overdose

He nui nā hopena kūpono ʻole e hiki mai ma hope o ka lawe ʻana i Glibomet, akā ʻaʻole pono ia ke kumu no ka hōʻole ʻana i ka lāʻau lapaʻau, no ka mea, ʻo ka hopena ʻeha i hōʻea i ke kino e ka uncompensated maʻa he nui loa ka kiʻekiʻe ma mua o ka hopena o ka hopena o ka hopena.

I mea e pale aku ai i kēlā mau kūlana, he mea nui e helu pololei i kāu maʻa. Inā overestimated ka maʻamau, hoʻāla ka maʻi diabetes i ka pōloli pōloli, ka nalowale o ka ikaika, ka huhū, lima nui.

Hiki ke ʻano o ka hōʻailona o ka overdose ke tachycardia, ke kīwaha ʻana o ka ʻili, hoʻonui nui ʻia, nāwaliwali.

ʻO nā hopena koʻikoʻi loa ma hope o ka lawe ʻana iā Glibomed, hypoglycemia e hōʻehaʻeha loa i kēia kūlana no nā poʻe maʻi e nawaliwali nei i kahi maʻi maʻi, maʻi diabetes, ʻo nā makahiki pākeke me nā maʻi lōʻihi, nā mea inu wai, ka poʻe i komo i ka hana kino paʻakikī, a me nā mea a pau e noho nei i ka hapalua nā ʻālunu. ua emi loa ma 1000 kcal / lā.) nā meaʻai.

ʻO nā hōʻailona maʻamau, ka mea maʻamau.

Nā Aliʻi
ʻO ka huakaʻi o ka Epigastric,
Nā maʻi Dyspeptic
Nā ʻano like ʻole o nā ʻano kūlohelohe.

Inā hele mai kaʻoluʻolu pōkole o ka pōpilikia ma hope o ka lawe ʻana i nā papa, hiki ke hoʻopau ʻia e ka hōʻailona hōʻailona. Inā hōʻeha nā hōʻailona a hōʻailona ʻole nā allergy, a laila pono ʻoe e koho i nā analogues no Glibomet.

Nā hopena hoʻopuka lāʻau lapaʻau

ʻO ka hoʻonui ʻana i ka hopena hypoglycemic o Glybomet i nānā ʻia i ka wā e pili ana i ka hopena me nā mea kikoʻī o ka decumarol, phenylbutamazone, β-blockers, oxytetracycline, allopurinol, cimetidine, ethanol, sulfinpyrazone i nā wai nui, probenecid, chloramphenicol, ka lāʻau nui, . ^ E Ha yM.

ʻO ka hui hoʻohui me nā hormones no ka thyroid gland, oral contraceptives, barbiturates, thiazide diuretic drug pale i ka hiki o Glibomet.

Nā ʻōlelo kikoʻī

Hoʻomaʻamaʻa koke ka hoʻohana ʻana o Glibomet i ka wā e loaʻa ai nā hōʻailona o ka acidosis lactic: nāwaliwali koʻikoʻi, luaʻi a me ka hōʻeha, ka naʻau o ka ʻeha o ka ʻōpū. Pono ka mea i hili i ka hoʻokaho.

Kauka ke aʻo i ka mālama ʻana me Glybomet e hele pū me ka nānā ʻana o ka creatinine i nā hōʻike koko. No nā mea maʻi me nā pēpē olakino, pono ia mea e pono ai ka hoʻokolohua i hoʻokahi manawa i hoʻokahi makahiki, nā poʻe maʻi e ʻike pono ana ka nui o ka creatinine i ka palena palena kiʻekiʻe o ka maʻamau, a pono e hoʻāʻo ʻia nā maʻi maʻi ʻo 2-4 mau manawa i kēlā me kēia makahiki.

ʻElua mau lā ma mua o ka hoʻolālā ʻana o ka hoʻomaʻamaʻa ʻana, kahi ke hoʻohana nei i ka anesthesia spinal a epidural paha, e lawe ana i Glibomet a kāpae ʻia a hoʻololi ʻia ka maʻi maʻi i ka insulin. ^ E Ha yM. Hiki iā ʻoe ke hoʻihoʻi i ka papa o ka mālama ʻana me Glybomet ma hope o ka ʻae ʻana i ka mea maʻi i nā meaʻai kūpono. ʻOiai me nā pēpē maʻamau e hana ai, ke hoʻoholo nei ke kauka i kēia hoʻoholo ma mua o ʻelua mau lā ma hope o ka hana.

Pono ka mālama ʻana i nā paila e mālama ʻia i ka wā e hoʻokau nei i nā hana i hiki i ke ola i ke ola a me ke olakino, like pū me ke kaʻa ʻana i nā kaʻa. Hoʻopili kēia i ka pilikia o ka hypoglycemia, kahi emi o ka hopena o ka hopena psychomotor a me ka hiki ke hoʻoikaika.

ʻO nā hopena o ka mālama ʻana me Glybomet e hilinaʻi nui loa i ka pololei o ka hoʻokō ʻana i nā ʻōlelo aʻoaʻo i ʻōlelo ʻia i nā ʻōkuhi a me nā ʻōlelo a ka endocrinologist: ka meaʻai a me ka hiamoe a me ka hoʻomaha ʻana, ka hana kino pilikino, ka mana o ka glycemic systematic, me ka home.

Ke hoʻohana ʻana i ka lāʻau lapaʻau, pono e hoʻokaʻawale i ka hoʻohana ʻana i ka wai ʻona ma mua o ka nui (ʻo ke ʻano he aniani o ka ʻulaʻula maloʻo hoʻokahi i ka hebedoma), no ka mea, e hoʻonāukiuki ana ka eʻai ʻana i ka hoʻomohala ʻana i ka glycemia, a me nā maʻi like ʻole a disulfiram - ʻeha i ka ʻāpaʻā epigastric, nā maʻi dyspeptic, pākaha wela i loko o ke kino ma luna a me ke poʻo, pau. coordination, headache, palpitations.

He kumukūʻai o nā lāʻau lapaʻau a me nā lula mālama

Loaʻa iā Glybomet ma ke kaulahao kūʻai? Wahi a ka moku'āina, hiki ke kūʻai ʻia ka lāʻau lapaʻau no 200-350 rubles. ʻO kēlā me kēia pūʻulu o Glibomet, ke kiʻi o ke kiʻi e ʻike ʻia ma kēia ʻāpana, aia iā 40 papa.
No ka nalowale ʻana o ka lāʻau lapaʻau ka hana pono ʻana, pono ia e pale ʻia mai ka lā pololei a me ka haʻahaʻa kiʻekiʻe.

Nā lāʻau like ʻole

Inā ʻo Glibomed ma loko o ka loaʻa ʻana o ka pela paʻakai, ʻaʻole ia e hāʻawi i ka hopena i makemake ʻia, he allergy a i ʻole nā hopena koʻikoʻi koʻikoʻi, ua hoʻololi ʻia ka lāʻau lapaʻau me nā mea hoʻomehana me kahi mea kūpono kūpono.

No Glibomed, hiki i nā lāʻau lapaʻau ke kau i nā papa Diabeton, nā mea hoʻomohala nui i ka glyclazide, a i Dimaril paha, aia ka ʻano hana like me nā mea like o Glibomed, glimepiride.

ʻO nā lāʻau lapaʻau antidiabetic e like me ka hopena like, ʻo Gluconorm, Bagomet Plus, Glucovans, Glibenclamide i hui pū me Metformin, ua kauoha ʻia ʻo Glyukofast.ʻO ka poʻe endocrinologist kahi mea e hoʻololi ai, nāna nō e helu i ka dosage. Hiki ke loli ka hoʻoponopono ʻia ʻana: ʻoi aku ke ʻano o nā analogues ma ke ʻano paʻakikī a me ke ʻano o ka monotherapy, ma ka hoʻohui i ka ʻai haʻahaʻa a me ka hana kino.

ʻAʻole hiki i 100% hiki ke wānana i ka hopena o ke kino i nā lāʻau hou, no laila ua pono ka manawa mua hoʻolohe i nā ʻōmole a pau a haʻi i ke kauka e pili ana i ka loli wikiwiki ʻana i ke kaumaha, anu malaise ākea, nā hopena o ka hōʻike glycemia me kahi glucometer a me nā mea ʻē aʻe i ka manawa o ka hoʻololi ʻana i nā ʻano kumu ʻē aʻe o nā hanana.

Hōʻikeʻike i nā hiʻohiʻona o Glibomet

E pili ana i nā loiloi o Glycomet e pili ana i nā maʻi maʻi i ka algorithm o kāna noi ma mua o ka hana pono.

Inā koho pololei ʻia nā dosage, he kūpono nā pane, i kekahi manawa aia nā mau kuhikuhi e pili ana i nā hopena ʻaoʻao. Akā no ka mea hoʻokahi kanaka kēia helu helu, hoʻokumu ʻia e pili ana i nā loiloi a me nā ʻano o ke ala o ka maʻi i kahi maʻi hoʻomanawanui, ʻo ka hoʻololi o ke ʻike i kēia ʻano he mea ʻole, a hiki i kekahi manawa kūpono ʻole ka hōʻino.

Ma ka hōʻuluʻulu ʻana i nā ʻōmaka āpau, hiki iā mākou ke manaʻo i ka Glibomed ke koho mua ʻana no ka laʻa type type 2 no ka monotherapy o ke kumukūʻai: kūpono ke kumukūʻai, kūpono ke kiʻekiʻe ʻana o ka palekana, ka neutrality me ka mahalo i ke kaumaha o ke kino, ka hopena maikaʻi i ka hopena cardiovascular a me ka hopena oncological.

ʻOiaʻiʻo, ʻaʻole hiki ke hoʻohana ʻia nā mea āpau (e like me nā lāʻau hypoglycemic ʻē aʻe) akā, kūlike ka lāʻau lapaʻau me nā kūlana o kēia mau kūlana a me ke kūpono.

Lapaʻau

Hoʻohui pū i ʻelua mau pūmole wahaʻōlelo hypoglycemic o nā ʻano lāʻau lapaʻau like ʻole: glibenclamide a me metformin.

Metformin nona nā hui o ka biguanides a hōʻemi i nā kiko o ka basal a me ka postprandial glucose i loko o ke koko koko. ʻAʻole ia e hoʻoikaika i ka metformin i ka huna ʻana i ka insulin a no laila ʻaʻole e kumu i ka hypoglycemia.He 3 mau mea hana o ka hana: ke hōʻemi nei ia i ka hana o ka glucose ma o ka ʻohi e ka pale ʻana i ka glucoseoneogenesis a me ka glycogenolysis, hoʻonui i ka ʻike ʻana o nā ʻoni ʻaina peripheral insulin, ka hoʻohana ʻana a me ka hoʻohana ʻana o ka glucose i nā ʻōpala i loko o nā uaua, a ke waiho nei i ka lilo ʻana o ka glucose i loko o ka pānaʻi ʻana. Mālama a hoʻoikaika paha i ke kaumaha o ke kino i nā mea maʻi me ka maʻi diabetes.

He hopena maikaʻi hoʻi kona i ka hoʻopili ʻana o ka lipid hoʻopili o ke koko, e hoʻemi i ka kolamu holoʻokoʻa, LDL a me ka triglycerides.

He hana like ka metformin me ka glibenclamide hana like, akā hoʻopiha pū kekahi i ka hana hypoglycemic a kekahi. ʻO ka hui pūʻana o nā ʻaihue hypoglycemic ʻelua he hopena synergistic ma ka hoʻemi ʻana i ka glucose.

ʻO Glibenclamide. Ke hoʻokau ʻia, mālamaʻia mai ka gastrointestinal tract ma mua o 95%. T max - 4 hola, V d - e pili ana iā 10 lita. ʻO ke kamaʻilio me nā protein plasma he 99%. Ua aneane holoʻokoʻa ia i loko o ke akea me ka hoʻokumu ʻana o ʻelua mau metabolites hana, a hoʻopiʻi ʻia e nā keiki (40%) a ma waena o nā mau palaka (60%). T 1/2 - mai 4 a 11 mau hola

Metformin ma hope o ka hoʻomoʻa waha ʻana, ua hoʻoneʻe ʻia mai ka ʻeha gastrointestinal piha loa, ua hōʻea ʻia ʻo C max i ka plasma i loko o nā hola 2.5. ʻO ka bioavailability piha loa mai 50 a 60%. Me nā ingestion like ʻole, ua hoʻemi ʻia a emi aʻe ke ʻano o ka hoʻopili ʻana o ka metformin. Hoʻolaha koke ʻia ʻo Metformin i loko o nā pā, hoʻomaʻamaʻa ʻole ia i nā protein plasma. Hoʻomili ʻia ia i kahi pae palupalu loa a hoʻopā ʻia e nā keiki. ʻO ka hoʻomaʻamaʻa o ka metformin i nā kumuhana olakinoʻo 400 ml / min, e hōʻike ana i ka hele ʻana o ka ʻoni kōheo ikaika. Ma kahi o 20-30% o metformin e hoʻopili ʻia ma o ka ʻōpū o ka loli. ʻO T 1/2 ka awelika o 6.5 mau hola. Ma ka ulia o kahi hana renal impaired, hōʻemi ka wehe ʻana o ka renal, e like me ka hoʻomaʻemaʻe ʻana o ka loina, aʻo ka māhuahua o T 1/2, ka mea i alakaʻi i ka pakanui plasma me ka ʻike ʻana. ʻO ka metformin a me glibenclamide i loko o kahi papa hoʻokahi i like ka bioavailability like me nā papa i loaʻa i ka metformin a i ʻole glibenclamide i ka hoʻokaʻawale. ʻO ka bioavailability o ka metformin i hui pū me ka glibenclamide ʻaʻole i loaʻa i ka ʻai kai, me ka bioavailability o glibenclamide. Eia nō naʻe, piʻi ka nui o ka emi ʻana o ka glibenclamide me ka ʻaina meaʻai.

ʻO ka hoʻohana nui ʻana o nā mea waiwai Glibenclamide + Metformin

ʻO ka type diabetes diabetes mellitus i ka pākeke me ka hiki ʻole o ka mālama ʻana i ka ʻaʻai papa, ka hoʻomaʻamaʻa kino a me ka monotherapy o mua me ka metformin a i ʻole ka hopena o ke kōmūlūlani, nā mea hoʻoneʻe i ka mua o nā maʻi me nā lāʻau lapaʻau ʻelua (metformin a me sulfonylurea derivative) i nā mea maʻi me ka pae hoʻomau a paʻa i ka maʻi glycemia.

Nā Hoʻohui

Hypersensitivity to metformin, glibenclamide or other sulfonylurea derivatives, type 1 diabetes mellitus, diabetes ketoacidosis, diabetic precoma, diabetic coma, renal failed or impaired renal function (creatinine Cl awe ma mua o 60 ml / min), mau maʻi koʻikoʻi e hiki ai ke alakaʻi i kahi loli nā pēpē: huehue, maʻi hōʻeha, nā haʻalulu, ka hoʻokalakupua intravascular o nā ʻāpana ʻokoʻa a iodine (e ʻike i nā "Hoʻomake i ʻole"), nā maʻi aʻeha paha e hele pū ʻia me ka hypoxia nā io: nā puʻuwai a me nā ʻole i ka hanu, ka wā o ka hala ʻana o ka maʻi myocardial, ka hōʻeha ʻana o ka ate, ka porphyria, ka hoʻohana ʻana i ka miconazole, nā maʻi hopohopo, nā hana hōʻiliʻili nui, nā hōʻeha, nā wela ākea a me nā kūlana ʻē aʻe e koi ana i ka hana ʻana i ka insulin, ʻokiʻoki i ka waipuna, ka hoʻohuʻihuʻi ʻana o ka ʻōpū, ka pakanika lactic ( komo i ka anamnesis), pili i ka meaʻai haʻahaʻa-emi (emi iho ma mua o 1000 kcal / lā), ka hapai, ka manawa o ka hānai, nā keiki ma lalo o 18 mau makahiki o kona mau makahiki.

ʻŌpū a me ka lactation

I ka wā hāpai, ua contraindicated ka hoʻohana. Hoʻomaʻamaʻa ʻia ka mea maʻi i ka wā o ka mālama ʻana me ka hui pū o nā glibenclamide + metformin, pono ia e hoʻomaopopo i ke kauka e pili ana i ka hāpai ʻana a me ka hoʻomaka ʻana o ka hapai. I ka wā e hoʻolālā ana i ka wā hāpai, ʻo ia hoʻi no ka hāpai ʻana i ka wā hāpai i ka wā e lawe ai i ka lāʻau lapaʻau, pono ia e hōʻaau, a ʻōlelo ʻia ke ʻano o ka insulin.

Ua hoʻohālikelike ʻia i ka wā o ka hōʻuluʻulu ʻana, no ka mea ʻaʻohe ʻikepili i hiki i ka hui pūpili glibenclamide + metformin e komo i loko o ka waiū umauma. Inā pono, e hoʻohana i ka wā o ka ʻōpiopio e hoʻololi i ka wailana o ka insulin a e hōʻoki paha i ka pale umauma.

Metabolism a me ka hoʻopā ʻana

Hoʻoweliweli a komo i loko o ka ate. ʻO ka hapa mua o ka hāpana e puka mai me ka urine, a ʻo ka lua o ka 50% e puka me ka bile. T1 / 2 - 3-16 hola.

Hoʻopuka a hoʻoili

Koho ʻia mai ka gastrointestinal tract e ka aneane 50%. ʻO ka bioavailability piha he 50-60%. Hoʻomaka koke ʻia i nā kiko, aneane ʻaʻole pili me nā protein plasma.

Metabolism a me ka hoʻopā ʻana

He palupalu nā metabolism, ua hoʻopuka ʻia mai ke kino me ka urine (kokoke i loko o kāna ʻano kumu) a me kahi hapa me nā feces. T1 / 2 - 9-12 hola.

Nā hōʻailona no ka hoʻohana ʻana

Hoʻololi ʻia kahi glibomet e ke kauka i ka mea maʻi e maʻi ana i ka maʻi type kīkē 2 i ka hihia inā he kīnā ʻole kaʻai ʻana, nā haʻuki a me ka hoʻomaʻamaʻa mua ʻana me ka glibenclamide a i ke metformin. Eia kekahi, hōʻike ka lāʻau lapaʻau no ka hoʻohana ʻana ma ke ʻano he hoʻololi pono no nā poʻe maʻi e loaʻa kahi ʻano o ka glycemia a me ka loli ʻole.

Hoʻolālā ʻia ka nui o ka pauku a me ka lōʻihi o ke kau ʻana, e hilinaʻi ke kauka i ka ʻāina o ka mea i hoʻoliʻoliʻiola ʻia o nā puʻukū a me ka pae o ka glucose i loko o ke koko.

ʻO ka hapa liʻiliʻi maʻa mau he 1 a 3 papa i kēlā me kēia lā. A laila koho ʻia ka nui o ka dosage a hiki i ka hopena kiʻekiʻe.

ʻO ke kānāwai, lawe ʻia nā papa ʻelua i kēlā me kēia lā i ke ahiahi a me nā hola o ke kakahiaka i ka wā o ka pāʻina.

ʻO ka palena kiʻekiʻe o kahi lāʻau glybomet ka nui o 5 papa i kēlā me kēia lā.

Nā hopena hopena

E pili ana i nā kaʻina metabolic, ka ulu ʻana o ka hypoglycemia a me ka hoʻonui ʻana o ka lactate koko. E pili ana i ka hoʻowalewale ʻana, hōʻike nā loiloi e loaʻa ka ʻono o ka "metala" i loko o ka waha, puʻu nui, ʻōpū a me ka nele o ka momona.

I kekahi mau hihia, ʻo ka hoʻohana ʻana o ka glibometa e hōʻeha ai i ka hepatitis, jaundice cholestatic a me ka hyperreactivity o nā enzyme o ka naʻau. Hiki i ka lāʻau lapaʻau ke hana i nā maʻi kūlohelohe, hōʻike ʻia i ke ʻano o ka urticaria, hoʻonāukiuki i ke ʻano o ka protein i ka urine, hoʻokauwī i ka ʻeha i nā ʻōpū a hana i ke kuni kiʻekiʻe.

Eia kekahi, ʻo ka loiloiʻana o ka maʻi maʻi ma hope o ka lawe ʻana i ka lāʻau lapaʻau e hōʻike ana i ka loaʻa o nā hopena dermatological (photosensitivity), ka hopena o ka hopohopo, ke poʻo, ka paresis, ka maʻi a me ka malaise.

ʻO kekahi manawa, ma hope o ka inuʻana i ka waiʻona, ʻo ka hoʻohana ʻana i ka lāʻau e hōʻeha i ka "hopena antabuse."

Nā hiʻohiʻona

Pono ke ʻano o ka lāʻau lapaʻau glybomet a me ka dosage ma lalo o ka mālama paʻa ʻana o kahi loea.

I ka hanana o ka acidosis lactic (convulsions, malaise, holo aila), pono ia e hooki i ka hoʻohana ʻana i ka lāʻau lapaʻau a hoʻokō i ka mālama pono.

Eia kekahi, pono e hoʻopiʻi ka mea maʻi i kekahi mau meaʻai, e pale i nā haʻukū o ka glucose, a inā e ʻike ʻia kekahi mau hōʻailona o ka acidosis lactic, e kamaʻilio koke i kahi kauka.

Nui! Ke hoʻohana ʻoe i ka glibomet, ʻaʻole pono ʻoe e inu i ka waiʻona.

Ua kuhikuhi aku i nā ʻōkuhi pili i ka lāʻau lapaʻau: i ke kaʻina o ke kaʻa ʻana i kahi kaʻa, hiki i kahi glibomet ke hōʻeha, no ka mea ʻaʻole i haʻalele ʻia ka ulu ʻana o ka hypoglycemia.

Ke keu

Inā kumu ka pā i kahi overdose, a laila ke ʻano o nā hōʻailona e like me ka lactic acidosis e kū nei ma muli o ka hana o ka metformin a me hypoglycemia e kū nei ma muli o ka hana o ka glibenclamide.

pololi
malaise
pilikia kino
hoʻonui hoʻonui ʻia
kō hoʻonohonoho paʻa ʻole o nā neʻe
palpitations
nā hiamoe mau ʻole
hāneʻe ʻula
ka manao o ka makaʻu
paresthesia i ka waha waha,
hiamoe a hiamoe ʻole
hāpau
poʻomanaʻo
hopohopo.

Inā hele ka hypoglycemia, a laila hiki ke lilo i ka naʻau a me ka kāohi ponoʻī.

Pono ka acidactact lactic i ka hoʻoponopono koke ʻana i kahi pae inpatient. ʻO ka hopena kūpono e pili ana i ka hemodialysis.

I ka hihia o ka hypoglycemia maʻalahi a hōʻemi paha e pono e lawe i ka syrup a i ʻole glucose. Ma ka hypoglycemia koʻikoʻi, ua hāʻawi ʻia kahi injra intravenous o kahi hopena glucose (40%) a i ʻole glucagon.

Nui! Ke hāpai ka mea maʻi i ka ʻike, pono ia e ʻai i nā meaʻai momona e pale ai i ka loaʻa ʻana o ka hypoglycemia.

Hoʻopili pū me nā lāʻau ʻē aʻe

Hiki i ka lāʻau lapaʻau ke hoʻonui i ka hopena hypoglycemic ma ka hopena o ka hoʻohana ʻoliʻiku o ka dicumarol, oxytetracycline, beta-blockers, sulfonamides, salicylates, chloramphenicol, ethanol, allopurinol, sulfinpyrazone, miconazole, MAO inhibitors, probenecid a cimetidine.

ʻO ka hopena o ka lawe ʻana i ka gibomet hiki ke hoʻemi ʻia e nā hormone thyroid a, inā ua lawe ʻia ka lāʻau me ka epinephrine, barbiturates, glucocorticosteroids, thiazide diuretics, contraceptives (nā papa).

Eia kekahi, hiki i ka lāʻau lapaʻau ke hoʻoikaika i ka hopena o ka lawe ʻana i nā antioagulants, a i ka wā e launa pū me ka cimetidine, hoʻonui i ka nui o ka acidact lactic.

Hiki ke nānā ʻia nā hōʻailona o ka hypoglycemia ma muli o nā beta-adrenolocators.

Hōʻikeʻike Kūleʻa-ʻAmelika Kauka 1

Ho‘ohana mahiʻai. ʻAe hui pūpū hypoglycemic aihue, kahi sulfonylurea derivative o ka lua o ka hanauna. Loaʻa ia i nā hopena pancreatic a me ka extrapancreatic hopena. Hoʻonohonoho ka Glibenclamide i ka huni o ka insulin ma o ka hoʻohaʻahaʻa ʻana i ka paepae no ka hoʻonāukiuki a me ka glucose o ka pancreatic beta, hoʻonui i ka naʻau o ka insulin a me kona paʻa ʻana i nā cell target, hoʻonui i ka hoʻokuʻu ʻana i ka insulin, hoʻonui i ka hopena o ka insulin ma ka ʻāʻī a me ka puʻuwai glucose uptake, a pale aku i ka lipolysis ma ka adipose tissue. Nā hana i ka lua o ka hana ʻana o ka inikini insulin. Hoʻopili ka Metformin i ka glucoseoneogenesis i loko o ka puʻuwai, e hoʻoneʻe ana i ka lilo ʻana o ka glucose i ka gastrointestinal tract a hoʻonui i kona hoʻohana i nā kōʻai, hōʻemi i nā mea o TG a me ka cholesterol i ka serum o ke koko. Hoʻonui i ka paʻa o ka insulin i nā receptors (i ka ʻike ʻole o ka insulin i loko o ke koko, ʻaʻole i hōʻike ʻia ka hopena therapeutic). ʻAʻole ia e kumu i ka pane hypoglycemic. Hoʻopilikia ka hopena hypoglycemic ma hope o 2 mau hola a lōʻihi o 12 mau hola.

Lapaʻau lāʻau ʻO Glibenclamide ka wikiwiki a kūpono i ka helu (84%) i loko o ka digestive tract, TC max - 7-8 mau hola.E kamaʻilio pū me nā protein plasma - 97%. Ua aneaneʻokoʻa loa i loko o ke kaohi i ka hana neʻe o nā metabolites. 50% hoʻopiʻi ʻia e nā ʻōpū, 50% - me ka bile. T 1/2 - 10-16 mau hola. Ma hope o ka lawe ʻana i ka pā i ka ʻalehina (hoʻoheheʻe ʻana - 48-52%), hoʻopili ʻia ʻo Metformin e nā ʻōpū (ʻoi aku ka loli ʻole), ma kahi o nā ʻāpana. T 1/2 - 9-12 h.

Nā Hōʻike. ʻO ka maʻi diabetes mellitus type 2 (me kaʻole o ka mālama ʻana i ka lāʻau papaʻai a i ʻole monotherapy me nā lāʻau hypoglycemic waha).

Nā Hoʻohui Hypersensitivity, type 1 diabetes mellitus, diabetes ketoacidosis, diabetes precoma a coma, lactic acidosis (me kahi mōʻaukala), hanaʻole (reninine ma mua o 135 mmol / l i nā kāne a ʻoi aku ma mua o ka 110 mmol / l i nā wahine), nā maʻiʻeha , ka mea e hiki ai ke hana i ka hana renal impaired (me ka dehydration, nā maʻi hōʻeha, ka pīhoihoi, ka hoʻopuka ʻana o nā ʻenehana kīwā o iodine), nā maʻi a me ka maʻi maʻi e hele pū ana me ka hypoxia kiko (e komo pū me ka puʻuwai, ka hāʻule ʻole o ka hanu, ka hōʻeha ʻana o ka naʻau myoca Ae, ke kŰia), hepatic insufficiency, huʻi waiʻona intoxication, porphyria, concomitant hoʻohana 'ana o ka miconazole, hāpai keiki, lactation.

Me ka makaʻala. Alkoholism, adrenal insufficiency, hypofunction o ka pituitary anterior, maʻi thyroid me ka hana lēwa.

ʻĀnō I loko, ʻoiai e ʻai ana. Kahi ʻia ka nui o ka pauku i hoʻoponopono ʻia, ma muli o ke ʻano o ke ʻano o ka hana ʻona. ʻO ka maʻamau, ʻo ka pā hoʻomaka i ka papa 1 (2.5 mg glibenclamide a me 500 mg metformin), me kahi koho ʻai o nā minamina i kēlā me kēia mau hebedoma 1-2 e pili ana i ka glycemic index.

Ke hoʻololi nei i ka lāʻau hui laʻa me ka metformin a me ka glibenclamide (e like me nā mea hoʻokaʻawale), nā papa 1-2 (2.5 mg o glibenclamide a me 500 mg o metformin) i kuhikuhi ʻia, e pili ana i ka hala o mua o kēlā me kēia māhele.

ʻO ka nui loa o ka lā i helu ʻia he 4 mau papa (2.5 a i ʻole 5 mg o ka glibenclamide a me 500 mg o ka metformin).

Loaʻa ka hopena. Metformin: nausea, luaʻi, ʻeha ʻeha, nalowale i ka makemake, ʻona "metallic" i loko o ka waha, erythema (me kahi hōʻike ʻana o ke ʻano hypersensitivity), ka hoʻohaʻahaʻa ʻana me, a me ka hopena, ʻo ka neʻe o ka cyanocobalamin i loko o ke koko koko (me ka hoʻohana mau ʻana), ka lactic acidosis.

Glibenclamide: hypoglycemia, maculopapular rash (me ka helu ʻana i ka membouses mucous), ka ʻeha o ka ʻili, urticaria, photosensitivity, nausea, luaʻi, hōʻeha i ka epigastric rehiyon, hoʻonui i ka hana transaminases, hepatitis, leukopenia, thrombocytosis, thrombocytopenia, thrombocytopenia, thrombocytopenia , aplasia ka ʻōpū o ka iwi, pancytopenia, cutaneous a me ka hepatic porphyria, hyponatremia, hypercreatininemia, hoʻonui urea i ke koko plasma, ʻano like me ka disulfiram (me ka hoʻohana like ʻana me ka ethanol).

Ke keu. Nā hōʻailona: hypoglycemia a me ka lactic acidosis.

Hanaʻiʻi: me ka hypoglycemia (inā ʻike ka mea maʻi) - ke kō i loko, me ka nalowale o ka ʻike - iv dextrose a i ʻole 1-2 ml o glucagon. Ma hope o ka ʻike hou ʻana, pono e hāʻawi i ka mea ʻai i ka mea maʻi i ka momona hoʻokaʻawale ʻia (i mea e pale ʻole ai ka hana hou o ka hypoglycemia).

Hoʻohui. He Miconazole ka hopena o ka hypoglycemia (a coma).

Fluconazole - ka hopena o ka hoʻouluʻana i ka hypoglycemia (hoʻonui i ka T 1/2 sulfonylurea derivatives).

Hiki i ka Phenylbutazone ke kahi o nā konukuna sulfonylureas (glibenclamide) mai ka pilina me nā protein, hiki iā ia ke alakaʻi i ka hoʻonui ʻana i ko lākou kaila koko a me ka hopena o ka hypoglycemia.

ʻO ka hoʻohana ʻana i ka lāʻau me ka mea nāna i i ka radiodine (no ka hoʻokō intravascular) hiki ke alakaʻi i ka hoʻomohala ʻana i ka hana ʻeha a me ka hōʻiliʻili o ka metformin, e hoʻonui ai i ka hopena o ka acidact lactic. Hoʻopau ke mālama ʻia me ka lāʻau lapaʻau mau hola 48 ma mua o ko lākou hoʻokele a hoʻomau ʻia ʻaʻole ma mua o 48 mau hola ma hope.

ʻO ka hoʻohana ʻana i nā mea ʻenehana e pili ana i ka etanol ma ke kua o ka glibenclamide hiki ke alakaʻi i ka hoʻolālāʻana o ka hopena disulfiram-like.

ʻO GCS, beta 2 -adrenostimulants, diuretics hiki ke alakaʻi i ka hōʻemi o ka hopena o ka lāʻau lapaʻau, pono paha ke hoʻoponopono ʻia.

ACE inhibitors - ka hopena o ka hypoglycemia me ka hoʻohana ʻana o sulfonylureas (glibenclamide).

Hoʻonui ka poʻe Beta-blockers i ka ulu a me ka koʻikoʻi o ka hypoglycemia.

ʻO nā lāʻau antibacterial mai ka hui o sulfonamides, fluoroquinolones, anticoagulants (dermaragine Coumarin), inhibitor MAO, chloramphenicol, pentoxifylline, lipid-hoʻemi iho i nā lāʻau mai ka pūʻulu o nā fibrates, disopyramides - ka hopena o ka hypoglycemia me ka hoʻohana ʻana o glibenclamide.

Nā ʻōlelo kikoʻī. ʻO nā hōʻiliʻili nui a me nā hōʻeha, nā wela ākea, nā maʻi maʻi me ka febrile syndrome e koi i ka hoʻopau ʻana i nā lāʻau glypoglycemic waha a me ka hoʻokeleʻana o ka insulin.

Pono e kiaʻi pinepine i ka pae o ka glucose i loko o ke koko ma kahi ʻōpū ʻole a ma hope o ka ʻai ʻana, ke kuapo o kēlā me kēia lā o ka waihona o ka glucose i loko o ke koko a me ka paʻi.

Hoʻomaʻamaʻa ʻia nā mea maʻi e pili ana i ka hoʻonui nui o ka hypoglycemia i nā hihia o ka ethanol, NSAID, a me ka pōloli.

Pono kahi hoʻoponopono hoʻoponopono ʻia no ke ʻano kūlohelohe a me ke kaumaha, kahi hoʻololi i ka ʻai.

Hoʻomaʻamaʻa ʻia nā mea pale i ka wā o ka maʻi me nā beta-blockers.

Me nā hōʻailona o ka hypoglycemia, ke hoʻohana nei ka hāmeʻe (gula) i nā pilikia koʻikoʻi, e lawelawe iki ka hopena o ka dextrose iv.No nā mea ʻeha, nā hōʻeha, nā maʻi hōʻeha, nā maʻi maʻi maʻi a me nā ʻūpī febrile, ke hoʻololi nei i ka insulin.

Pono e kāpae i ka lāʻau lapaʻau i nā lā 2 ma mua o kekahi hoʻokolilo angiographic a i ʻole urographic examination (hoʻihoʻi ʻia ke ʻano he 48 mau hola ma hope o ka hōʻike.

E kūlike i ke ʻano o ka hoʻohana ʻana i nā mea e pili ana i ka ethanol, ka hiki ke hoʻomohala ʻia ka hopena o ka disulfiram-like.

I ka wā o ka mālama ʻana, pono e mālama ʻia i ka wā e alakaʻi ana i nā kaʻa a komo i nā hana ʻē aʻe ʻē aʻe e koi ai i ka nui o ka neʻe ʻana a me ka wikiwiki o ka hopena psychomotor.

Kākau mokuʻāina i nā lāʻau lapaʻau. Hoʻopuka kūmole: i 2 mau leo M: Medical Council, 2009. - Vol. 2, ʻāpana 1 - 568 s., ʻĀpana 2 - 560 s.

ʻO nāʻoihana pili me nā mea ikaika ʻē aʻe

Hoʻonui ka Acarbose i ka hopena hypoglycemic o ka hui pūʻana o ka glibenclamide + metformin.

Alopinae *

Hoʻonui ka Allopurinol i ka hopena hypoglycemic o ka hui ʻana o ka glibenclamide + metformin.

Ascorbic acid *

I nā wai kiʻekiʻe, ascorbic acid (acidifying urine of drug) i hoʻonui i ka hopena o ka hui ʻana o ka glibenclamide + metformin e ka hōʻemi ʻana i ka pae o ka dissociation a me ka hoʻonui ʻana i ka reabsorption o glibenclamide.

Asparaginase

Hoʻokomo nā Asparaginase i ka hopena o ka hui pūʻana o ka glibenclamide + metformin.

Acetaui

ʻO ka Acetazolamide palupalu i ka hopena o ka hui pūʻana o ka glibenclamide + metformin.

Hoʻopili ʻo Baclofen i ka hopena o ka hui pūʻana o ka glibenclamide + metformin.

Kepokia

Hoʻonui ka Bezafibrat i ka hopena hypoglycemic o ka hui pūʻana o ka glibenclamide + metformin.

Pihaola *

Hoʻonui ka bromocriptine i ka hopena hypoglycemic o ka hui pūʻana o ka glibenclamide + metformin.

Alakaʻi *

Hoʻopaunu ʻia e Glucagon ka hopena o ka hui ʻana o ka glibenclamide + metformin.

Inā pono, ʻo ka koho manawa me ka hui pū o ka glibenclamide + metformin danazole a ke kū nei ʻoe i ka lawe ʻana i hope, pono ʻoe e hoʻoponopono i ka nui o ka hui ʻana ma lalo o ke kaʻi o ka pae o ka glycemia (he nui ka hopena o ka pūzolima a hōʻeha i ka hopena).

Kālehana

Hoʻonui ka Disopyramide i ka hopena hypoglycemic o ka hui pūʻana o ka glibenclamide + metformin.

Hoʻopili ka Isoniazid i ka hopena o ka hui pūʻana o ka glibenclamide + metformin.

Kālā calcium

ʻO ka calcium kalepa e hoʻoneʻe i ka wai o ka lāʻau lapaʻau) hoʻohui i ka hopena o ka hui ʻana o ka glibenclamide + metformin e ka hōʻemi ʻana i ka pae o ke kipi a me ka hoʻonui ʻana i ka reabsorption o glibenclamide.

Hoʻonui ka Cebookril i ka hopena hypoglycemic o ka hui pūʻana o ka glibenclamide + metformin a hoʻonui i ka hopena o ka hoʻomohala ʻana i nā hopena hypoglycemic ma o ka hoʻomaikaʻi ʻana i ka pale ʻana i ka glucose a hoʻemi i ka pono o ka insulin.

Hoʻonui ka Miconazole i ka hopena o ka hui pūʻana o ka glibenclamide + metformin, hiki ke hoʻonāukiuki i ka hoʻomohala ʻana o ka hypoglycemia (a hiki i ke kūkuluʻana i ka coma).

Niacin *

ʻO ka hoʻohuihui Nicotinic (ma nā helu koʻikoʻi) e hoʻonāukiuki i ka hopena o ka hui ʻana o ka glibenclamide + metformin.

Hoʻonui ka Nifedipine i ka hoʻopili ʻana a me ka C max o metformin a lūlō i kāna excretion.

Pokula1

Hoʻonui ka Pentoxifylline i ka hopena hypoglycemic o ka hui ʻana o ka glibenclamide + metformin.

Pyridox *

Hoʻonui ka Pyridoxine i ka hopena hypoglycemic o ka hui ʻana o ka glibenclamide + metformin.

Huihui *

Hoʻonui ka Reserpine i ka hopena hypoglycemic o ka hui pūʻana o ka glibenclamide + metformin.

Keula *

Hoʻonui nā Rifampicin i ka hopena o ka hui pūʻana o ka glibenclamide + metformin.

Naokohole *

Palupalu ʻo Salbutamol i ka hopena o ka hui pūʻana o ka glibenclamide + metformin.

Hoʻonui ka theophylline i ka hopena hypoglycemic o ka hui ʻana o ka glibenclamide + metformin.

Haunalekula *

Hoʻokomo ʻo Terbutaline i ka hopena o ka hui pūʻana o ka glibenclamide + metformin.

Mailani *

Hoʻonui ka Tetracycline i ka hopena hypoglycemic o ka hui pūʻana o ka glibenclamide + metformin.

Hoʻonui ka Furosemide iā C max metformin e 22% a AUC ma ka 15% (me ka loaʻa ʻole o nā loli nui. Hoʻopau ka Metformin ma C max furosemide e 31%, AUC e 12% a me T 1/2 e ka 32% (me ka loaʻa ʻole o nā loli nui.

Pihaileiik

Hoʻonui ka Chloramphenicol i ka hopena hypoglycemic o ka hui pūʻana o ka glibenclamide + metformin.

Kapauli

ʻO Chlorpromazine i nā haʻahaʻa kiʻekiʻe (100 mg / lā) e hoʻonāwaliwali ai i ka hopena o ka hui ʻana o ka glibenclamide + metformin, no ka mea kumu e hoʻonui ai i ka glycemia.

Kahalule *

Ua hōʻea ke Chlortalidone i ka hopena o ka hui pūʻana o ka glibenclamide + metformin.

ʻO Cimetidine (kahi lāʻau lapaʻau cationic) i hūnā ʻia i loko o nā tubule e hoʻokūkū ana no nā ʻōhua o ka tubular a hoʻonui i ka C max metformin e 60% a AUC e 40%.

Hoʻonui ʻo Enalapril i ka hopena hypoglycemic o ka hui pūʻana o ka glibenclamide + metformin a hoʻonui i ka hopena o ka ulu ʻana i nā hopena hypoglycemic ma o ka hoʻomaikaʻi ʻana i ke kūpaʻa glucose a hoʻemi i ka pono o ka insulin.

ʻO ka Epinephrine palupalu i ka hopena o ka hui pūʻana o ka glibenclamide + metformin.

Me ka hoʻomohala like ʻana o ka hui o ka glibenclamide + metformin a me ka waiʻona, hiki i ka hōʻeuʻeu o ka hoʻomohala ʻana i nā hopena hypoglycemic, me nā hihia o ka coma, a me ka lactic acidosis e hoʻonui ʻia, no laila e pale ʻia nā hui pū.

Hoʻonui ka Ethionamide i ka hopena hypoglycemic o ka hui pūʻana o ka glibenclamide + metformin.

Hoʻomaʻa pinepine ʻia i ka mālama ʻana i nā maʻi mellitus type 2, ʻaʻole lawa ka hoʻohana ʻana wale nō i kekahi o nā kuhikuhi he ʻelua o nā papa o ke kō. Pono e hoʻohui ʻia ʻo Biguanides a me nā ʻokoʻa ʻē aʻe i ka mālama ʻana me nā derivatives o sulfonylurea.

Hiki i nā lāʻau lapaʻau ke hana i ka lāʻau Glibomet, kahi hui kūleʻa o nā hui ʻelua a hoʻopihapiha, e hoʻomaikaʻi i nā ala o ke kahe, nā hopena i nā pilikia o ka poʻe e ʻeha nei ma kēia maʻi.

Manaʻo ʻia ka lāʻau lapaʻau Glibomet e hoʻōla i ka pae o ke kō i loko o nā mea maʻi me ka maʻi diabetes type 2, no ka mea e hoʻāʻo nei e lawe i ke kō i ke koko i ka maʻamau me ka papaʻai ʻana i ka meaʻai, lawe ʻia ka derebory o sulfonylurea a i ʻole biguanides.

ʻO ka hoʻonohonohoʻana o ka lāʻau lapaʻau ke komo pū me 2 mau mea ikaika:

glibenclamide 2,5 mg - he mākaʻikaʻi o ka lua o ka hanauna olakino sulfonylurea,
ʻO Metformin 400 mg kahi mea hoʻopiʻi o nā biguanides.

Hōʻike ʻia ka papahū papaha papa hoʻohālikelike e ka pūʻali maʻamau o nā mea hoʻohiki.

Aia ma luna o nā papa i hoʻopili ʻia me ka pani a talc me ka hoʻohui o kekahi o nā ʻano like o cellulose a me ka diethyl phthalate.

Ka hana lāʻau lapaʻau

Ma ka lawe ʻana i nā papa Glibomet, ua loaʻa nā pahuhopu ʻelua:

ka hōʻemi iki o ka nui o ke kō i nā palena maʻamau,
hoʻoponopono o nā momona momona.

He aha nā mea i hana ai? Hāʻawi ke ʻano o kēlā me kēia ʻāpana.

Hoʻonui ka Glibenclamide i ka hana huna o ka insulin i ka pancreas (intrapancreatic effect) a hoʻomaikaʻi i ka ʻike ʻana o nā io i kekahi i nā periphery (extrapancreatic effect). Ma lalo o kona mana, hoʻokomo ʻia ka glucose mai ka moena vascular i nā hepatocytes a i loko o nā uaua, kahi i hana ʻia ai ka depot glycogen.
Hoʻonui ka Metformin i ka hoʻowalewale ʻana o nā kōpili peripheral i ka insulin, ke pale i ka lilo ʻana o nā glucose i loko o ka ʻōpū o ka ʻōpū, hana ʻia kona synthesis i ka wā o ka gluconeogenesis, a hoʻomaikaʻi i ka metabolism momona.

ʻO ka hopena synergistic o nā ʻāpana ʻelua i hiki ai ke hōʻemi i ka hapa nui o kēlā me kēia me ka ʻole e hōʻino i ka hopena therapeutic, i loaʻa i 2 mau hola ma hope o ka hoʻokele ʻana a lōʻihi nā hola 12. Eia kekahi, hōʻemi kēia i ka hopena o nā hopena pili.

I ke kino, ʻano ʻē ka ʻano o ka glibenclamide a me ke metformin. Hoʻopaʻa ikaika ʻo Glibenclamide i nā protein protein a hōʻiliʻili ʻia i loko o nā ate, ma hope o ka hoʻopiʻi ʻia ʻana e ka ʻili a me ka urine ma ke ʻano o nā metabolite ʻaʻole i hana ʻia. ʻAʻole komo ʻo Metformin i ka hoʻohui me nā protein, e komo i loko o nā kōpona, kahi e hana ai me ka ʻole o ka metabolized. Hoʻopili ʻia ia me ka urine, kahe ma waena o nā ʻōpū.

Nā ʻōkuhi no ka hoʻohana

Hōʻike ʻia ka ʻikepili e pili ana i ke ʻano o nā hoʻokele a me nā hala ma nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana o Glibomet.

Hoʻokahi wale nō ala e lawe ai i ka lāʻau lapaʻau - lawe ʻia nā papa me ka maʻamau. ʻO ka maʻa mua ma waena mai o 1 a 3 mau papa i ka lā. I ka wā e hiki mai ana, ke koho ka endocrinologist i kekahi ka waiʻī, ke noʻonoʻo nei i ke kūlana o ka mea maʻi a me ka pae gula. ʻAʻole loa e hoʻonā i ka nui o ka lā ma kēlā me kēia lā papa.

Hoʻoholo ʻia ka dosage i koho ʻia e ke kauka ma ke hoʻoponopono ʻana i ka wā o ka mālama ʻana a me ka mālama ʻana i ke kō. ʻO ke kumu o ke koho wīwī e hōʻoia i ka normalization o nā pae koko koko.

Pono e mālama pono i ka holo ʻana a me ka hana ʻana me ka neʻe ʻana i nā mīkini.

Hoʻopili me nā lāʻau lapaʻau ʻē aʻe

ʻO ka pilina me kekahi o nā lāʻau lapaʻau e alakaʻi i ka hoʻonui ʻana i ka hopena hypoglycemic. E pili ana kēia:

mākaukau launa
liuliu
mau pōʻai beta
sulfonamides,
MAO ka mea paʻa
miconazole
kaena alkohol.

Hoʻonui ka Glibomet i ka hopena o nā anticoagulants.

ʻO ka hopena ʻē aʻe o ka hypoglycemia:

kekahula
nā mea hoʻohālikelike waha
diuretics of the thiazine series,
pani ʻia
adrenaline
ʻO nā hormones thyroid.

Hoʻopuka nā pā poli līkika i nā hōʻike olakino o ka hypoglycemia, hiki ke pilikia i kahi maʻi maʻi.

ʻO nā ʻaihue Iodine i hoʻohālikelike ʻia i loko o kahi vein i mea e hōʻiliʻili ai ka metformin, a no laila aia kahi hoʻoweliweli o ka acidact lactic

Aia nā loea o Glibamet ma ka hana a me ka ʻano.

ʻO Glucovans kahi hui hoʻohui e hana i ka hana hypoglycemic, i hana ʻia e Merck, Palani. Nā papa e pili ana i ka glibenclamide a me ka metformin i loko o nā pūʻulu blister o 15 mau papa. Ma ka pākī 2 a i ʻole 4 mau moho.
ʻO ka Metglib - kahi hui like, nā papa o 40 mau ʻāpana i kēlā me kēia pēpē.
Bagomet-hoʻohui - ʻo ia mau mau mea like me 2, akā he ʻokoʻa ka pākana. I loko o kahi pākana o 30 mau papa. Hoʻokahi ʻAmelika.
ʻO Gluconorm - ua hui pū ʻia me nā mea like ʻelua, 40 ʻāpana i kēlā me kēia.
ʻO nā mea hoʻohālikelike Glibomet e ʻokoʻa i ka hoʻonohonoho ʻana akā like ka hana i ka:
Hoʻokumu ʻia ʻo Amaryl ma muli o glimepiride 1.2.3.4 mg i nā lūlū o 15 mau ʻāpana, ma kahiʻaoʻao o 2, 4, 6 a i 8 mau laha paha. Loaʻa i Kelemānia.
ʻO Maninil a me Diabeton - e pili ana i ka glibenclamide, he kumumea o ka waiʻo sulfonurea 2.
Maninil - nā papa kuʻu 1,75 mg, 3,5 mg a me 5 mg o nā ʻāpana 120. Mea hana - Berlin-Chemie, Kelemānia.
ʻO ka Diabeton MV - 30 a 60 mau papa o 60 mau papa a i ʻole 30 mau papa pākahi. Servier Laboratory, Farani kahi mea hoʻolako waiwai.

No ka hoʻohālikelike, pono e hāʻawi ʻia ʻo Maninil - Diabeton i kahi makemake i Diabeton, me he mea laʻoki ʻole ka hōʻemi.

I ke kumukūʻai, ʻo Glybomet a me kāna mea kikowaena like me ka pilina like.

ʻO ke kumukūʻai kumukūʻai no Glibomed mai 200 a 300 mau rubles.
ʻO Glucovans - ke kumukūʻai o ke kumukūʻai ma waena o 250 - 350 rubles.
E kūʻai ʻia ana ʻo Bagomet-plus no 225 -235 mau rubles.
Hiki ke kūʻai ʻia ka metglib ma aneane no 230 rubles.
Kumukūʻai Maninil 130 -170 mau rubles.
Ma ka maʻi hupa i loko o nā palena o 159 - 202 mau rubles.
ʻO ke kumu kūʻai o Amaryl mai 150 a 3400 rubles. Kuhi ʻia ʻo Amaryl i ke kumukūʻai kiʻekiʻe loa ma ka nui loa o ka make ʻana o 4 mg o 90 papa.

Home »Cholecystitis» Glibomet - nā ʻōlelo no ka hoʻohana ʻana i ka lāʻau lapaʻau, nā loiloi. Hypoglycemic oral drug o ka lua kahiki glybomet

Pehea e lawe ai iā Glibomet

Ma ka hoʻokolokolo ʻana e ka loiloi o nā endocrinologists, i mea e pale ai i ka acidosis lactic, maʻi maʻi ʻoihana ma mua o 60 mau makahiki o ka makahiki, me ka hoʻomaʻamaʻa kino ʻana i kēlā me kēia lā, pono ʻoe e lawe i ka lāʻau lapaʻau me ka makaʻala, hoʻopaʻa pinepine i ka glucometer ma ka diary.

Ke kau nei nā kau palena iā Glibomet:

Nā hoʻonohonoho hoʻonohonoho a hoʻokuʻu i nā palapala

ʻO ka pūnaehana o ka papa Glibomet ka ʻelua o nā hana ikaika, ʻo ia hoʻi o ka glibenclamide, a me ka metformin hydrochloride, ka nui o ka hapa o kēia mau mea he 2.5 mg a me 400 mg, kēlā me kēia. Hoʻohui hou ʻia:

ʻO Glycerol dibehenate
ʻO Povidone
ʻO ke kinikini silica colloidal
ʻO ka lāʻau ʻo Magnesium
ʻO ka sodium Croscarmellose
Macrogol.

Ua puni nā papa, a waiū kekona, aia ka pilikia ma kekahi ʻaoʻao. Hoʻokomo ʻia nā papa i loko o kahi pūʻulu blister o 20 mau p., I loko o kahi pūʻulu o 2 mau palaka.

Hoʻomaopopo i nā waiwai

No ka Glibomet ka helu o ka lāʻau hypoglycemic me ka hui pū ʻana, ʻo nā mea ikaika e pili ana i ka sulfonylurea, a me ka lua o ka hanauna biguanide. Hoʻokomo ka lāʻau lapaʻau i ka hoʻohuihuiʻana o ka insulin i ka pancreas ma muli o ka hoʻohaʻahaʻa i ka paepae o ka hoʻonāukiuki β-cell e ka glucose pono'ī. Māhuahua ka hoʻonui i ka mea hiki i ka insulin, ʻoiai e hoʻopili ana i nā pūpū pili i hoʻonui ʻia, a hoʻomaikaʻi ʻia ka insulin. I ka wā o ka lāʻau antidiabetic, hana ʻia ke kaʻina o ke kūpaʻa o ka glucose e nā pupu a me nā mākau a me nā mākala, e pale aku i ka lipolysis e loaʻa ana i nā pā adipose. Kuhi ʻia ka glibenclamide ua hoʻopaʻa ʻia i ka lua o ka hana o ka huna ʻana o ka insulin.

He lālā ʻo Metformin i ka hui ʻo Biguanide. He hopena hoʻonāukiuki ia e pili ana i ka hoʻihoʻi ʻana o ka io i nā insulin, e hoʻohiolo i ke kaʻina o ke kūmole glucose i ka pololei o ka ʻōpū, pale ʻia i ka gluconeogenesis, a hoʻopilikia pū kekahi i ka papa o lipid metabolism. E kue i kahi o kēia hopena kiko'ī, hiki i ka wikiwiki ke hōʻemi i ka nui o ke kino i ke kanaka e maʻi nei i ka maʻi maʻi.

Ka hopena hypoglycemic o ka hua'ōlelo Glibomet i hoʻopaʻa ʻia 2 mau hola ma hope o ke manawa o ka lawe ʻana i nā papa a ua mālama nā hola 12 aʻe. Ma muli o ka hui pū ʻana o nā mea hana ʻelua, hana ʻia ke kāpili o ka mea i kapa ʻia ʻo ka endogenous insulin, ka hopena nui o ka biguanide ʻaʻole wale ma luna o ka ʻiʻo a me ka iwi adipose, akā, ma ka ʻōpū o ke akeo (ma muli o ka emi o ka gluconeogenesis). Ma kēia hihia, ʻaʻole i hoʻopaʻa ʻia ka hoʻonāukiuki ikaika o ka cell-cell o ka pancreas, kahi e hōʻemi ana i nā kino o nā pathologies organ a me ka hoʻomohala ʻana i nā hōʻailona ʻelua.

ʻO ka pae o ka hoʻopaʻa ʻana o ka glibenclamide e ka mucosa gastrointestinal e pili ana i ka 84%. ʻO ka helu kiʻekiʻe o kēia mea i ke koko i hoʻopaʻa ʻia ma loko o 1-2 mau hola ma hope o ka hoʻohana ʻana i nā lāʻau. Ke kamaʻilio pū ʻana me nā protein plasma - 97%. ʻO ka hoʻololi ʻana o ka metabola o kēia māhele i loko o nā wahī o ke akeʻa; Ma ke kaʻina hana o nā huahana metabolic, ua komo ka gastrointestinal tract a me ka ʻōnaehana renal. ʻO ka hoʻopauʻana hapa hapalua-maʻamau maʻamau ʻaʻole iʻoi aku ma mua o 5-10 mau hola.

ʻO ke kumu o ka hoʻopili ʻana o ka metformin e ka mucosa gastrointestinal he kiʻekiʻe. Ke komo nei ia i ka ʻōnaehana o ka ʻōnaehana, ua ʻike ʻia kona wikiwiki ʻana i nā kao i loko, ʻaʻole hoʻi ia i komo i kahi pilina me nā protein plasma. Hoʻopili ʻia kēia ʻano mea i hōʻiliʻili ʻia, hoʻopili ʻia e nā ʻōnaehana renal a me nā mea ʻole. ʻO ka hapalua hapalua o ke metformin he 7 mau hola.

Glibomet: nā ʻōkuhi piha no ka hoʻohana

ʻO ka lāʻau i manaʻo ʻia no ka hoʻoponopono waha. Lawe iā Glybomet me nā meaʻai. Koho ʻia ka nui o ka maʻi me ka hoʻoponopono ʻia ʻana e mālama i nā hōʻailona hōʻike i loaʻa, ka nui o ke kūpaʻa o ka glucose i ke koko, a me ke ʻano holoʻokoʻa o ka metabolism o ka paʻakai.

Hoʻomaʻama pinepine, ʻo ka papa ʻai kumu mua o ka lāʻau Glibomet ka 1-3 papa. Ke hele nei i ka wā antidiabetic therapy, ke koho pono ʻia ai ka hopena kūpono loa, e ʻae ai e hōʻemi i ka pae o ka glucose i nā kumu maʻamau. He mea kūpono ia e nānā i ke kiʻekiʻe o kēlā me kēia lā o ka lāʻau lapaʻau he 6 papa.

ʻO ka wehewehe ʻana o ka haku mele. Puka i ka Hoʻolaha Kauka

Loaʻa ka lāʻau lapaʻau "Glibomet" i ke ʻano o nā papa hāmeʻa keʻokeʻo me kahi puʻu paʻakikī. Hoʻokomo ʻia lākou ma nā pololi kūpono o 20 mau ʻāpana. Ma loko o ke kalapona hiki iā ʻoe ke kūʻai i kahi pūpū me nā waihona ʻelua.

ʻO kēia kahi mea hana i hoʻohui ʻia, no laila, ke hui pū ʻia nā mea hana ʻelua - glibenclamide (2,5 ml i hoʻokahi papa) a me ka metformin i ke ʻano o ka hydrochloride.ʻO ka pono, aia ka mākaukau i ka mea me nā mea kōkua, inā paha, ka pauka palaoa, silicon dioxide, microcrystalline cellulose, talc, diethyl phthalate, glycerin, cellulose acetate phthalate, gelatin.

Pehea ka hopena o ka lāʻau lapaʻau i ke kino?

ʻO kaʻoiaʻiʻo, e hoʻomaka me, he mea kūpono e hoʻomaopopo i ka waiwai o ka lāʻau. Hoʻoholo ʻia ka hopena hypoglycemic o ka hoʻomākaukau ʻana no Glibomet e ke ʻano o nā mea ʻelua ʻelua i ka manawa hoʻokahi.

Hoʻohana kēia mea hana i ka pancreas, ʻo ia hoʻi nā wahi e kuleana ana i ke kino. I ka manawa like, hoʻonui ka lāʻau i ka maʻi o nā ʻōpiopio ʻona o kēia hormone. No laila, kōkua ʻo Glibomet e hoʻohaʻahaʻa i ke kō koko koko me ka ʻole o ka hoʻohana ʻana i ka insulin synthetic, kahi mea koʻikoʻi loa no ka maʻi diabetes type 2.

Loaʻa i ka lāʻau i nā waiwai lipid-hoʻohaʻahaʻa. Ma lalo o kona mana, e hoʻemi ana ka pae o ka momona i ke koko, e hoʻemi ana i ka hōʻemi o nā clots i loko o ke koko (clots getih). Aia ʻo Metformin i ka hui o nā biguanides. Hoʻopuka kēia mea i nā kaʻina hana o ka hoʻohanaʻana i ka glucose e nā ʻōpū, pale i ka gluconeogenesis i loko o nā koʻala o ka ate, a pale aku i ka adsorption o nā kalama e ka paia o ka ʻili.

Hoʻopili koke ʻia ʻo Glibenclamide e nā paia o ka ʻōpū a kokoke i kēlā me kēia (97%) i hoʻopaʻa ʻia i nā protein plasma. I loko o nā puʻuwai, e wāwahi ia, hana i nā metabolites hana ʻole, kahi e hoʻoiho ʻia aku ai mai ke kino aku me nā feces a me ka urine. ʻO ka hapalua-ola kahi 5 hola. Hoʻoulu koke ka Metformin i ke kino, akāʻaʻole paʻa i ka protein plasma. ʻAʻole kala ʻia kēia waiwai ma ke kino. like me na hora elua.

I ka wā e hoʻohana ʻia ai ka lāʻau lapaʻau?

Ua nui ka poʻe i kahi maʻi e like me ka maʻi diabetes type 2. He mea nui loa ka ʻaihue a me ka mālama ʻana i kēia hihia. Ma ke kānāwai, no ka poʻe maʻi nā mea e pono ai ka meaʻai kūpono. Hiki iā ʻoe ke hoʻoponopono i kāu kō koko koko me ka sulfonylureas.

ʻO ka lāʻau lapaʻau "Glibomet" i ʻōlelo ʻia inā he lāʻau lapaʻau e lawe ana a me ka lawe ʻana i nā kālā i luna aʻe, ʻaʻole ia e hāʻawi i ka hopena pono.

Pehea e lawe ai i ka lāʻau lapaʻau "Glibomet"? Hoʻoholo kū hoʻokahi ka Dosage i hoʻokahi. Ma ke ʻano he kānāwai, ʻelua mau papa ʻelua. Lawe ʻia lākou me ka meaʻai. Eia kekahi, hoʻonui ʻia ka nui o ka lāʻau e hoʻokō ai i ka hopena kiʻekiʻe. ʻAʻole pono nā lā o kēlā me kēia lā e 2 g o ka metformin. Ma hope, ua hōʻemi ka wili.

ʻO ka lāʻau "Glibomet": contraindications no ka mālamaʻana

ʻO kahi lāʻau lapaʻau koʻikoʻi maikaʻi loa kēia, ʻo ka hoʻokipa ʻana i ka mea e hiki ke ʻae ʻia me ka ʻae ʻana o ke kauka. He hōʻano kupanaha nā lāʻau lapaʻau e pili ana i nā contraindications, kahi āu e hoʻomaʻamaʻa ai iā ʻoe iho ma mua o ka hoʻomaka ʻana o ka mālama ʻana.

hypersensitivity o nā mea ikaika a me nā mea kōkua o nā papa,
ka maʻi pili i nā derivatives sulfonylurea, a me ka sulfamide, probenecid a sulfamide diuretics paha,
contraindicated kēia mākaukau i ka wahine i ka wā hāpai,
ka nele o ka hopena mai ka hopena,
maʻiʻeleʻele coma a me nā kūlana predomatous
pilikia maoli pilikia
huehue
nā maʻi ʻohi
nā maʻi a me nā maʻi e hiki ke alakaʻi i ka hoʻomohala ʻana i ka kiko hypoxia,
nā maʻi ākea o ka ʻōnaehana cardiovascular, ka hoʻohui pū ʻana me nā pilikia me ke kaila o peripheral, ka huina myocardial, ka maʻi pehu a me ka weliweli cardiov,
nā maʻi ʻeha mua o ka ʻōnaehana hanu,
myocardial infarction a hoʻoponopono manawa paha ma hope o ia,
ka hana like me ka diuretics a me nā lāʻau lā no ke koko kiʻekiʻe,
acidosis a i ʻole ka pilikia o kona hoʻomohala ʻana,
ka heleʻana o ka moʻolelo o ka mea maʻi ma nā hihia o ka lactic acidosis,
maʻi ʻino ʻeha
nā pilikia hoʻi o ka ʻōnaehana hanu,
Hoʻoulu hou ʻia ma hope o ka hoʻokaʻawale ʻana o nā pancreas,
halawai holookoa,
inu waiʻuhā, kahi ʻano o ka inu ʻakaʻaka.
ka hopena wailua
gangrene
lactation
ka hookeai ana paha ma kaʻai ʻana i kahi meaʻai paʻa.

Inā loaʻa ʻoe kekahi o nā contraindications ma luna, a laila pono e hōʻike ʻia i ka endocrinologist.

He aha nā hopena maikaʻiʻole hiki ke alakaʻi i ka lāʻau?

Manaʻo mau ʻia ka palekana e lawe i nā papa Glibomet? Hiki i nā hopena ʻokoʻa ma ke ʻano o ka mālama ʻana. ʻO nā hihia o kā lākou hanana, akā naʻe, ʻaʻole i kākau pinepine ʻia, akā hiki i ka lawelawe ke hōʻeha i nā ʻōnaehana like ʻole.

Pūnaehana limu a me ke koko . ^ E Ha yM. Hemolytic anemia, leukopenia, thrombocytopenia, pancytopenia, erythrocytopenia.
CNS . ^ E Ha yM. He wā hōʻeha i ka ʻeha, ka hoʻāʻo ʻana i ka ʻono.
Nā Organs o ka hihiʻo. ʻO nā hemahema o ka noho, kahi i hoʻemi ʻia i ka acuity ʻike, kahi i hoʻopili ʻia me kahi loli o ke kō koko koko.
Hāpai . ^ E Ha yM. ʻO ke hoʻonui koʻikoʻi ma ke kaumaha o ke kino, hypoglycemia, lactic acidosis. ʻO ke kaʻina lōʻihi o ka manawa kekahi e alakaʻi i ka hoʻopio ʻana o ka vitamin B12 i loko o ka ʻawaʻawa, a ma hope ke kākoʻo ʻana i ka hana megaloblastic.
ʻŌnaehana nenoaiu . ^ E Ha yM. ʻO ka ale, ka luaʻi, ka ʻūhū, ka ʻeha i ka ʻāina epigastric, ke kāʻei pinepine ʻana, ka nalo ʻana o ka makemake, ka ʻano o ke ʻano o ka metallic o loko o ka waha, i ka piha o ka ʻōpū.
ʻO ka ʻili a me ke kiko kikoʻī . ^ E Ha yM. ʻO ka ʻeha ʻili, erythema, nā ʻano like ʻole o ka exanthema, hoʻonui i ka mālamalama o ka ʻili o ke kino i ka mālamalama, dermatitis allergic, urticaria.
Allergic hopena pili . ^ E Ha yM. ʻO nā ʻeha ma ka ʻili, ka huehue, ka jaundice, ke emi ʻana o ka nui o ke koko, ke kaumaha ʻana i ke kaumaha, nā ʻano haʻalulu.
Pāʻālua . ^ E Ha yM. Intesthiatic cholestasis, lāʻau lapaʻau maʻi.
ʻO kekahi mau ʻōuli'ē aʻe e ʻike ʻia, ʻoi aku ka nui o ka nui o ka urine, ka nalowale o ka protein a me ka sodium e ka kino ma muli o ka hopena filtration i loko o nā pūpū.

He mea nui ia e ʻike ʻole ʻia ka hapa nui o nā hoʻopiʻi ma luna nei ʻaʻole pono e hoʻokuʻu i ka hopena o ka maʻi - ua lawa ia e hōʻemi i ka nui o nā maʻi a me nā hopena ʻino e hele ana ma kā lākou iho. Pono ke hoʻonui o kēlā me kēia lā o ka lāʻau lapaʻau a lūlū a mālie.

Hōʻike e pili ana i nā kamaʻilio me nā lāʻau lapaʻau ʻē aʻe

ʻAʻole hiki ke lawe ʻia ka lāʻau "Glibomet" (metformin) me ka waiʻona ethyl, no ka mea e hoʻonui ai i ka hoʻomohala ʻana i ka waikena lactic. I ka wā o ka maʻi, pono e hoʻoneʻe ʻia ka wai a me nā mea inu wai.

Hoʻohana ʻia ka hoʻohana ʻana o kēia lāʻau lapaʻau he 48 mau hola ma mua o nā kaʻina hana a nā iodine e pili ana i nā kūlike. ʻO ka hoʻohana pinepine ʻana i kēia mau lāʻau hiki ke alakaʻi i ka hiki ʻana o ka hana ʻole ʻole.

Inā ʻoe e lawe "Glibomet" me insulin, anabolic steroid, beta-adrenergic blockers, tetracycline mau lāʻau lapaʻau, a laila piʻi aʻe ka hopena o ka ulu ʻana o ka hypoglycemia. Pono nā maʻi diabetes e hoʻomaopopo i kā lākou kauka e pili ana i nā lāʻau lapaʻau a lākou e lawe ai.

ʻO nā kumuʻai a me nā analog

I ka lāʻau lapaʻau o kēia wā, hoʻohana pinepine ka lāʻau "Glibomet". ʻO nā loiloi o nā maʻi maʻi, mau hōʻailona a me nā contraindications nā mea, ʻoiaʻiʻo, nā mea nui. Akā ʻaʻole ka mea nui o nā kumu nui. Heʻoiaʻiʻo, paʻakikī ka inoa ʻana i ka helu helu, akā ma ka awelika o ke kumukūʻai o kahi papa he 40 mau papa mai 340 a 380 rubles, ʻoiai ʻaʻole maoli loa.

ʻOiaʻiʻo, ʻaʻole kūpono kēia mau lāʻau no nā maʻi. ʻAi nā nui o nā kūlā kūʻai i ka mākeke o nā mea i kēia manawa. No ka laʻana, me ka maʻi diabetes o ka ʻano lua, e like me ke ʻano he Avandamet, Vokanamet, ʻo Glukovans e hoʻohana pinepine ʻia. ʻAʻole i emi iki pinepine, hoʻokaʻawale ʻia nā maʻi iā Dibizid, Dianorm a i Sinjarji. ʻO kaʻoiaʻiʻo, ʻo ka mea komo i ka endocrinologist hiki ke koho i kahi kikowaena kūpono.