ʻO Lozarel Plus > He hoʻomaʻemaʻe a me ke pale aku

Lozarel Plus: nā ʻōlelo aʻoaʻo no ka hoʻohana a me nā loiloi

Latin inoa: Losarel Plus

Manaʻo ATX: C09DA01

ʻO ka papa hana: hydrochlorothiazide (Hydrochlorothiazide) + losartan (Losartanum)

Mea Hana: LEK dd (LEK d.d.) (Slovenia)

Hoʻouka i ka wehewehe a me ke kiʻi: 11.28.2018

ʻO nā kumukūʻai ma nā lāʻau lapaʻau: mai ka 120 rubles.

ʻO Lozarel Plus kahi lāʻau lapaʻau antihypertensive hui pū ʻia.

E hoʻokuʻu i ke ʻano a me ka ʻano

Ka puka ana - nā papa kīwī i uhi ʻia: nā pōpō, biconvex, ma kahi pā melemele kukui, me kahi kīkī mai ke keʻokeʻo me kahi keehi melemele a hiki i ke keʻokeʻo (ma ke kāwele pepa o nā papa he 3-6, 8, 10 a i ʻole 14 mau kohu paha i loaʻa 7 a 10 paha papa, a me nā kauoha no ka hoʻohana ʻana iā Lozarel Plus).

ʻO ka hana o 1 papa (12.5 mg + 50 mg) / (25 mg + 100 mg) pili:

nā mea hana ʻehā: hydrochlorothiazide - 12.5 / 25 mg, pāhare pāpale losartan - 50/100 mg (me ka losartan - 45.8 / 91.6 mg a me ka pāhau - 4.24 / 8.48 mg),
Nā mea kōkua (inti): microcrystalline cellulose - 60/120 mg, lactose monohidratile - 26,9 / 53.8 mg, ke kōkau pregelatinized - 23.6 / 47.2 mg, colloidal silicon dioxide - 0,5 / 1 mg, stearate magnesium - 1.5 / 3 mg,
palapala kiʻiʻoniʻoni: hyprolose - 1.925 / 3.85 mg, hypromellose - 1.925 / 3.85 mg, titanium dioxide - 1.13 / 2.26 mg, dye iron oxide yellow - 0.02 / 0.04 mg.

ʻO nā waiwai Pharmacological

ʻO Lozarel Plus ka hui pū ʻana o losartan (kahi antropist (theiotiotinin II receptor antagonist) a me hydrochlorothiazide (thiazide diuretic). ʻO ka hui pū ʻana o kēia mau lako me ka hopena antihypertensive hoʻohui a hoʻohaʻahaʻa i ke koko (koko koko) i kahi nui aʻe i ka hoʻohālikelike ʻana me ka hoʻohana ʻana o kēia mau māhele e like me ka monotherapy.

Hoʻopilikia ka hopena hypotensive o Lozarel Plus no 24 mau hola, ʻoi loa ka hopena therapeutic hopena e loaʻa i loko o ʻehā mau pule o ka hoʻokomo.

Lapaʻau lāʻau

ʻO Losartan kekahi o nā antagonist kikoʻī o ka ʻĀpana ngiotensin II (type AT1). Ma hope o kona hoʻoponopono ʻana, ka angiotensin II koho paʻa loa i nā ʻĀpana AT1 e kū ana i nā koena ʻokoʻa (ma nā kelepaʻi adrenal, nā pihi lipulle o nā hāhi koko, nā puʻuwai a me nā puʻuwai), a me kekahi mau hana koi nui e hana, me ka hoʻokuʻu ʻia ʻana o ald testosterone a me vasoconstriction. Hoʻoulu ʻia hoʻi ka Angiotensin II i ka hoʻomaikaʻi ʻana o nā pūpū māla maikaʻi.

E like me nā hualoaʻa o nā haʻawina, losartan a me kāna metabolite E-3174, e hōʻike ana i ka hana pharmacological, ālai i nā hopena āpau o ka fula o ka angiotensin II, ʻaʻohe o nā kumu a me kāna ala biosynthesis.

ʻO Losartan ACE (angiotensin e hoʻohuli ana i ka enzyme), ʻaʻole ia e hoʻokaʻawale i ka kininase II, a, no laila, ʻaʻole i pale i ka luku ʻana i ka bradykinin. No laila, ʻaʻole hiki i nā hopena maikaʻiʻole ke pili me ka bradykinin (ma ke ʻano kūikawā, angioedema) he mea maʻamau loa ia. ʻO Losartan a me kāna metabolite hoʻoikaika e loaʻa i kahi pilina nui loa no nā receptors angiotensin aʻu i ʻae aku no nā ʻoniʻoni angiotensin II. ʻO ka metabolite ikaika o losartan ka mea ikaika eʻoi aku ma mua o ka waiwai, ma kahi o 10-40 mau manawa. Nā hana i hoʻonoho ʻia o ka losartan a me kāna metabolite hoʻoikaika i loko o ke koko, a me ka hopena antihypertensive o ke ʻano e hoʻonui ʻia ai ke ʻano o ka hopena o Losarel Plus. No ka mea ʻo losartan a me kāna metabolite ʻoihana he antagonist o nā ʻĀnela maʻa angiotensin II, ua kōkua lāua ʻelua i ka hopena hypotensive.

ʻO nā hopena nui o ka losartan a me kāna metabolite E-3174:

ʻO ka emi ʻana o ke kaomi o ke koko a me ke kaomi ʻana i ka pīpī pulmonary, he hōʻemi i ka nui o ke kūlia o ka peripheral kūlia o ke kīʻaha koko a me ka ʻike ʻana o ka ald testosterone i loko o ke koko,
ma hope o ka hoʻemi ʻana
ka hāʻawi ʻana i ka hopena diuretic,
kaohi ʻana i ka hoʻomohala ʻana o ka hypertrophy myocardial,
mahuahua i ka hoʻomanawanui i ka hoʻomanawanui me ka puʻuwai puʻuwai (kaomi ʻana i ka puʻuwai naʻau),
ka paʻa ʻana o ka u ka plasma o ka urea i ke koko.

ʻAʻole pā paha ka losartan a me kāna metabolite hoʻoikaika i ka loina vegetative; ʻaʻole lākou e hopena i ka hopena lōʻihi i ka neʻe ʻana o ka plasma o norepinephrine i loko o ke koko.

ʻO ka hopena antihypertensive (ma ke ʻano o ka hoʻohaʻahaʻa i ka systolic a me ka hoʻonaninani diastolic) ma hope o ke ʻano o ka lawelawe waha nui i hōʻea i kona waiwai nui loa i 6 mau hola, a laila e emi iki ka hopena ma luna o 24 mau hola. Hoʻohui ka hopena kiʻekiʻe antihypertensive ma hope o 3-6 mau pule o ka maʻi.

Kūkulu ʻia i loko o nā hoʻokolohua lapaʻau e pili ana i nā mea maʻi me ka hōʻemi a me ka hōʻemi nui o ka hypertension arterial mua, ʻike ʻia ka nui o ka nui ma ka systolic a me ka diastolic blood pressure e like me ka lawe a losartan i hoʻokahi manawa i ka lā. Ke hoʻohālikelike nei i ke kahe o ke koko 5-6 a me 24 mau hola ma hope o ka hoʻokomo ʻana i kahi pākahi o Lozarel Plus, ua ʻike ʻia ʻoiai ke mālama nei i ka rula kūlohelohe o kēlā me kēia lā, noho haʻahaʻa ke koko no 24 mau hola. I ka hopena o ke dosing, ʻo ka hoʻolohi ʻana o ke kahe koko e pili ana i 70-80% o ka hopena i nānā ʻia i nā hola 5-6 ma hope o ka lawelawe waha ʻana o losartan.

Ke haʻalele ka losartan e nā mea maʻi me ka hypertension arterial, he piʻi nui loa o ke kahe koko (withdrawal syndrome) ʻaʻole mālama ʻia. ʻO ka mea, ʻoiai ke kuhi ʻia ʻana o ke kahe o ke koko, ʻaʻohe hopena koʻikoʻi o ka hōʻeha i ka puʻuwai puʻuwai.

ʻAʻole hilinaʻi ka hopena therapeutic o losartan i ka kāne a me nā makahiki o ka mea maʻi.

ʻO ka hole waiwai

ʻO ka Hydrochlorothiazide kahi diuretic thiazide. ʻO kāna mau hopena koʻikoʻi he meaʻole i ka reabsorption o ka chlorine, sodium, magnesium a me ka potassium i loko o ka nephron distal, e kōkua ana i ka lohi ʻana i ka hoʻōla ʻana o ka uric acid a me ka calcium. Me ka hoʻonui nui o ka renal excretion o kēia mau ion, e hoʻonui ka nui o ka nui o ka urine (ma muli o ka wai o ka osmotic wai).

Hoʻemi ka waiwai i ka nui o ka plasma koko, aʻo ka hana o renin i ka plasma koko e hoʻonui a hoʻonui i ka biosynthesis o aldosterone. ʻO Hydrochlorothiazide i nā haʻahaʻa kiʻekiʻe e hāʻawi i ka hoʻonui i ka hoʻopuka o nā bicarbonates, me ka hoʻohana lōʻihi - i kahi hoʻemi ma ka excretion calcium. Hoʻoulu ka hopena antihypertensive ma muli o ka hoʻemi ʻana o ka nui o ke koko kahe, ka hoʻololi i ka hoʻohālikelike ʻana o ka paia vascular, kahi i hoʻokahe ʻia i ka hopena pressor o vasoconstrictive amines (adrenaline, norepinephrine) a me ka hoʻonui ʻana i ka hopena hōʻeha i ka ganglia. ʻAʻole pili ka mea i loko o ke kahe koko maʻamau. Hoʻomaopopo ka hopena diuretic i nā hola 1-2, hoʻonui ʻia ka hopena kiʻekiʻe ma 4 mau hola, ʻo ka lōʻihi o ka hopena diuretic mai 6 a 12 mau hola.

Hoʻopilikia ka hopena therapeutic ma hope o nā lā 3-4 o ka hoʻokele, akā e lawe ʻia mai 3 a 4 mau wiki e hoʻokō ai i ka hopena hypotensive maikaʻi loa.

Lapaʻau lāʻau

Ma hope o ka lawelawe waha, ua maikaʻi maikaʻi ka losartan mai ka gastrointestinal tract. Hoʻomili ʻia ia me ka hiki mua o ka puʻu ma ka carboxylation me ka komo ʻana o ka isoenzyme o ka cytochrome CYP2C9, me ka hoʻokumu o ka metabolite ikaika. ʻO ka bioavailability o ka ʻōnaehana ma kahi o 33%. ʻAʻole pili ka ʻai i kēia kuhikuhi. He manawa e hiki ai i C_max (ka uka nui) o losartan a me kāna hana metabolite i ka serum koko ma hope o ka hoʻokele waha - 1 a me 3-4 mau hola, kēlā

ʻO ka mea a me kāna hana metabolite paʻa e hoʻomoʻa i nā protein plasma i ka pae ma mua o 99%, nui me ka albumin. V_{e d} (ka laulā o ka nui) 34 mau lita. ʻAʻole komo ʻo Losartan i ka pale koko-lolo.

ʻO ka hoʻololi i ka pākuʻi pharmacokinetic o ka waiwai a me kāna metabolite hōʻeuʻeu ma hope o ka lawe ʻana i 200 mg o ka losartan i ka lula ma ka hapa ʻina ma kahi i lawe ʻia.

Me ka ʻoi o ka hoʻokele ʻana i ka manawa 1 i kēlā me kēia lā, ʻike nui ka hōʻuluʻulu o ka losartan a me kāna metabolite i loko o ke koko koko. ʻO ka hoʻohana hoʻokahi i kēlā me kēia lā o 100 mg ʻaʻole e kumu i kahi hōʻiliʻili nui o nā mea a me nā metabolite i loko o ke kaila koko.

Ma kahi o 4% o ka loaʻaʻana o losartan e hoʻohuli i ka metabolite ikaika. Ma hope o ka helu ʻana i ka inoa ʻo 14 C me losartan, ʻo ka radioactivity o ke kaila koko kahe e pili pono ana me ka lilo ʻana o kahi mea a me kāna hana metabolite ma loko. Ma kahi o 1% o nā hihia, ʻike ʻia kahi haʻahaʻa o ka metabolism haʻahaʻa.

ʻO ka Plasma a me nā clealce renal (kēlā me kēia): losartan - kahi ma kahi o 600 a me 74 ml / min, kona metabolite hoʻoikaika - e pili ana i ka 50 a me 26 ml / min. Ma kahi o 4% o ka make o losartan e hoʻololi ʻia e nā keiki, ma kahi o 6% - e like me ka metabolite hoʻoikaika. Hoʻololi ka Plasma i nā waiwai a me kāna hoʻohaʻahaʻa metabolite hoʻoneʻe nui me ka T hope_1/2 (elimination half-life) pili i 2 a me 69 hola, kēlā. Lawe ʻia ka ʻōkuhi e nā ʻōpū a me ka bile. Ma hope o ka loaʻa ʻana o ka lepili 14 C o losartan, ma kahi o 58% o ka radioactivity e loaʻa i nā loina, 35% ma nā urine.

E kū'ē i ke kiʻi o ke aniani a me ka hōʻeha nui o ka wai cirrhosis ngohi i ka hoʻohālikelike ʻana, me ka hoʻohālikelike ʻana me nā limahana kāne ikaika, ʻo ke kukuna o losartan a me ka metabolite hoʻoikaika e hoʻonui i ka 5 a me 1,7 mau manawa, ia.

Hoʻohālikelike ka ʻaina o losartan i loko o ke kaila koko me CC (clearance creatinine) ma luna o 10 ml / min, ʻaʻole i ʻokoʻa mai ka mea i ʻole o ka hana renal impaired. I nā maʻi maʻi hemodialysis, ʻo ke kumukūʻai AUC (ʻo ka wahi ma lalo o ka manawa o ka lūlū ʻana i kēlā me kēia manawa) he 2 a ʻoi aku ka kiʻekiʻe ma mua o ka make ʻole o ka hana renal. Me ka hemodialysis, ʻaʻole i lawe ʻia ka losartan a me kāna metabolite hoʻoikaika.

I nā wahine me ka hypertension arterial, ʻokoʻa nā waiwai o ka hōʻiliʻili plasma o losartan ma mua o nā waiwai i kau ʻia e nā kāne he ʻelua, aʻo nā kāne a me nā wahine ʻaʻole i ʻokoʻa nā manaʻo o ka metabolite ikaika. ʻAʻole loaʻa kahi hōʻailona koʻikoʻi o kēia pharmacokinetic.

Nā Hoʻohui

pilikia hōʻeha loa (i nā maʻi me CC ma lalo o 30 ml / min),
hōʻeha kaumaha o ka ate (e like me ke Keiki - inu ʻona, ʻoi aku ma mua o 9 mau hola).
Anuria
lactase kakali, malabsorption syndrome a me ka lactose intolerance,
ʻO ka maʻi Addison
hōʻailona gout a me / aiʻole hyperuricemia,
hipua paiena- a me hypokalemia, hypercalcemia, hipocipia refractory,
huki, me nā mea e pili pū ana me ka hoʻohana ʻana i nā inikini kiʻekiʻe o ka diuretics,
paʻakikī e pale i ka maʻi diabetes
maʻi hypotension ikaika,
hui pū me nā aliskiren a me nā aliskiren i loaʻa i nā mea maʻi i nā mea maʻi me ka hana renal impaired (me kahi maʻi filtration glomerular o 2) a me / a i ʻole diabetes mellitus,
hapai a me lactation,
makahiki i 18 makahiki
ka molaki ʻana o kēlā me kēia mea o ka lāʻau, me nā lāʻau lapaʻau e hiki mai ana o ka sulfonamide.

Relative (Lozarel Plus e kuhikuhi ʻia ma lalo o ka nānā mālama olakino):

hui pū me nā mea non-steroidal anti-inflammatory drug (komo me ka cyclooxygenase-2 inhibitors),
lawa hemahema,
nā kuhi ʻana o ke kaulike o ka wai-electrolyte o ke koko, no ka laʻana, e pili ana i ka maʻi ʻaʻa a i ʻole ka luaʻi (hyponatremia, hypomagnesemia, hypochloremic alkalosis),
bilateral renal aren stenosis a i ʻole stenosis kahi o hoʻokahi keiki,
hana hōʻeha (i nā maʻi me CC 30-50 ml / min),
kaumaha ʻana i ka mōʻaukala a me ka maʻi bronchial,
ka maʻi ʻōpiopio holomua a me ka hana lēpaa lēwa (e like me ke ana o ke keiki-Pugh, a emi mai ka 9 mauʻaoʻao),
nā maʻi ʻōnaehana o ka io hoonui (me nā systemic lupus erythematosus),
puʻuwai paʻakikī me nā arrhythmias weliweli ola,
stenosis aorta a mitral valve paha.
myopia ʻoiʻi a me ka pōkole pelekane ʻokoki hoʻopihapiha (e pili ana me ka hydrochlorothiazide),
maʻi maʻi coronary
hypventrophic pono e hoʻonani,
hyperaldosteron's,
mau kūlana ma hope o ka hiki ʻana o ka hakahaka (ʻaʻoheʻike me ka hoʻohana ʻana).
maʻi mellitus maʻiʻi
no ka lāhui ʻeleʻele.

Nā hopena hopena

Ma nā hoʻokolohua lapaʻau me ka losartan a me hydrochlorothiazide, ʻaʻole i mālama ʻia nā hopena ʻino e pili ana i kēia lāʻau i hui.

Ua kaupalena ʻia nā hopena ʻokoʻa i kēlā mau mea i hōʻike ʻia i ka wā e hoʻohana ana i nā mea hoʻoikaika o Losarel Plus e like me ka monotherapy. Ma ka huina, ua hoʻohālikelike ka pinepine o nā hopena maikaʻi me ka hui pū me kēia me ka placebo.

Ma keʻano holoʻokoʻa, hoʻolahalaha maikaʻi ʻia ka lāʻau lapaʻau me ka losartan a me hydrochlorothiazide. I ka nui o nā hihia, he ʻoluʻolu nā hopena hopena, hoʻololi ʻia i ke kino a ʻaʻole i alakaʻi i ka hoʻopau ʻia o Lozarel Plus.

Wahi a nā hopena o nā hoʻokolohua lapaʻau koʻikoʻi, i ka mālama ʻana o ka hypertension pono, ʻo ia wale nō ka hopena e like me ka hoʻokele ʻana o Lozarel Plus, ʻoi aku ka nui o kēlā me ka placebo iʻoi aku ma mua o 1%.

Eia nō naʻe, i ka wā e hoʻokele ai i nā haʻawina, ua loaʻa i loko o nā mea maʻi me ka hypertrophy left ventricular a me ke hypertension arterial, ʻo ka maʻi maʻamau ka mea: ʻo ka nui o ka palupalu, nāwaliwali, nā ʻōnaehana systemic / non-systemic.

I ka hana ʻana o nā ʻike like ʻole, me ka nānā ʻana o ka nānā ʻana ma hope iho o ka hoʻopaʻa inoa ʻana, ua hōʻike ʻia nā hopena hope loa> 10% - pinepine pinepine (> 1% a 0.1% a me 0,01% a me 5.5 mmol / L), pinepine - he hoʻonui nui ʻana i ka kukuna serum urea / ke koena hauola a me ka mea hana i loko o ke koko, ke ʻano pinepine loa i ka hyperbilirubinemia, ke hoʻonui nui ʻana i ka hana o nā transaminases hepatic (aspartate aminotransferase a me alanine aminotransferase), me ka pinepine ʻole maʻamau - hyponatremia,

ka maʻi maʻamau: pinepine - hoʻonui i ka momona, asthenia, edema peripheral, ʻeha ma ka ʻōpū o ka umauma, pinepine - i ke ala, ka ʻūhā o ka maka, me ka ʻike mau ʻole - nā maʻi maʻi like-flu, malaise.

Hiki i nā hopena ʻino mai nā ʻōnaehana a me nā kino ma muli o ka hydrochlorothiazide:

pūnaehana cardiovascular: pinepine - - hypotension orthostatic, arrhythmias, vasculitis,
ka pānaʻi ʻana o ka hoʻopuna: pinepine - hoʻonāukiuki i ka mucosa o ka gastric, jaundice cholestatic, cholestasis intrahepatic, cholecystitis a pancreatitis, ʻehaʻeha, maʻiʻa, hele aihue, cramping, constipation, sialadenitis, anorexia,
urinary system: pinepine - interstitial nephritis, renal gagal, impalired renal function,
ʻūnaehana nūnaehana: pinepine - ʻeha, kuʻuna - paʻakikī, hoʻoweliweli, paresthesia, ʻōpala,
ke ano o ka maʻi pākiha: pinepine - ka maʻi ʻeha o ka hanu (me nā edema pulmonary non-cardiogenic a me ka maʻi pneumonitis), urticaria, vasculitis necrotic, purpura, Stevens-Johnson syndrome, ʻeha - ka hopena anaphylactic, hiki paha ke hoʻōho.
ke koko a me ke ʻano limu: pinepine - thrombocytopenia, leukopenia, agranulocytosis, aplastic / hemolytic anemia,
ʻola o ka ʻike: ke ʻano - xantopsia, pōkole ke ʻano he anuanu, me ka loaʻa ʻole o ka neʻe - ʻili o ka pani
ʻili a me ka ʻili o ka subcutaneous: pinepine - i ʻole nā lānīpīpī i ka epicima, ka hoʻokaʻawale ʻana me ka hua ʻole - lupus erythematosus,
ka hana 'ana a me ke olakino: ka pinepine - hypomagnesemia, hypokalemia, hyperglycemia, hyponatremia, glucosuria, hyperuricemia me ka hoʻomohala' ana i ka huiki o ka gout, hypercalcemia a me hypochloremic alkalosis (i hōʻike ʻia i ke ʻano o ka xerostomia, makewai, ʻōpio puʻuwai ʻokoʻa, hoʻololi i ka psyche / mood ʻāʻī, nilo, luaʻi, ʻeha ʻole a nāwaliwali ʻole, hypocloremic alkalosis hiki ke alakaʻi i ka hoʻomohala ʻana o ka hepatic encephalopathy / hepatic coma), hyponatremia (hōʻike ʻia e like me ka hilahila, nā koi , Lethargy, lohi manaʻo kaʻina, excitability, luhi, Muscle cramps) i Inc thiazide hiki hihia hoʻi monakō koko ioeeiiaiey, ke kahe i hoike latent mimikō mellitus, ma ka hihia o ke kiʻekiʻe nā māhele ke hoonui i ka lāʻau lapaʻau lehulehu o lipids i loko o ke koko,
nā mea'ē aʻe: pinepine - nā ʻōpio mākeke, nā manawa i hōʻemi ʻia.

Ke keu

ʻO nā hōʻailona kumu nui o ka makeʻana o nā hana ikaika o Lozarel Plus:

losartan: tachycardia, hōʻailona hōʻailona i ka emi o ke koko, bradycardia (pili me ka vagal stimulation),
hydrochlorothiazide: nalowale o ka electrolytes (ma ke ʻano o hypokalemia, hyperchloremia, hyponatremia), a me ka dehydration, e ulu ana ma muli o ka diuresis nui, ma ka hopena o ka hana concomitant me ka glycosides cardiac, hypokalemia hiki ke hoʻonāukiuki i ka papa o nā arrhythmias.

Ka lāʻau: kākoʻo a me ke ʻano. Inā hala kahi manawa liʻiliʻi mai ka hoʻokipa ʻana, pono ʻoe e holoi i ka ʻōpū, e like me nā hōʻike ʻana, hoʻoponopono ʻia ka hoʻonāukiuki ʻana o ka pilikia wai-electrolyte. ʻAʻole i hoʻoneʻe ʻia ka Losartan a me nā neʻe ikaika o ka hemodialysis.

Pākuʻi helu

ʻO nā papa kiʻi ʻoniʻoni 50 mg / 12.5 mg, 100 mg / 25 mg

Aia ma ka papa papa

mau mea ikaika: losartan potassium 50 mg, hydrochlorothiazide 12.5 mg a i ʻole

pāhare pāpale 100 mg, hydrochlorothiazide 25 mg

nā mea waiwai: lactose monohydrate, microcrystalline cellulose, pregelatinized starch, magnesium stearate, anhydrous colloidal silicon dioxide

hana kiko: hypromellose, hydroxypropyl cellulose, yellow iron oxide (E 172), titanium dioxide (E 171), macrogol (400) (no kahi ala o 100 mg / 25 mg), talc (no kahi inana o 100 mg / 25 mg).

ʻO nā papa ʻoniʻoni kīwī, he aniani i ka waihoʻoluʻu, ʻōniʻoniʻo ma kona ʻano, me ka papa biconvex.

ʻLoe a me ke kākele

Hiki ke kuhikuhi ʻia ʻo Lozarel Plus e hui pū me nā mea hana ʻē aʻe antiihypertensive.

Pono e hoʻohana lima ʻia nā papa me ke aniani o ka wai, me ka ʻaina ʻole.

ʻAʻole i ʻae ʻia ka paʻakai losartan a me hydrochlorothiazide e like me ka hoʻomaka ʻana o ka maʻi ma mua, akā ua kuhikuhi ʻia i nā poʻe maʻi e ʻike ʻole ai ka hoʻohana ʻana o ka losartan potassium a i ʻole ka hydrochlorothiazide e pili ana i ka lawa kūpono o ke kahe koko.

Hoʻomaopopo ʻia kahi dosis titration o kēlā me nā papalua (potassium losartan a me hydrochlorothiazide).

I ka manawa e pono ai i nā maʻi maʻi, i nā maʻi e ʻike ʻole ʻole i ke koko, hiki ke noʻonoʻo ʻia kahi hoʻololi kūlohelohe a hiki i kahi hui paʻa.

ʻO Lozarel Plus 50 mg / 12,5 mg papa i poni ʻia ʻoniʻoni

Nā maʻi mālama mālama mau: 1 papa 50 mg / 12.5 mg 1 manawa i kēlā me kēia lā.

No nā mea maʻi ʻaʻole lawa loa ka pane, hiki ke hoʻonui ʻia i ka nui no 2 papa o 50 mg / 12.5 mg i hoʻokahi lā a i ʻole 1 papa o 100 mg / 25 mg hoʻokahi i ka lā.

Ma ke ʻano he kānāwai, ua hoʻokō ʻia ka hopena antihypertensive i loko o nā hebedoma 3-4 ma hope o ka hoʻomaka ʻana o ka hoʻōla.

Lozarel Plus, nā pani ʻoniʻoni kiʻi 100 mg / 25 mg Paʻa kiʻekiʻe: 1 papa 100 mg / 25 mg hoʻokahi i ka lā.

Ma ke ʻano he kānāwai, ua hoʻokō ʻia ka hopena antihypertensive i loko o nā hebedoma 3-4 ma hope o ka hoʻomaka ʻana o ka hoʻōla.

Hoʻohana i nā mea maʻi me ka hana renal impaired a ma ka poʻe maʻi ma ka hemodialysis.

I nā mea maʻi me ka hana renal moderole (i.e. clearance cleince is 30-50 ml / min), ʻaʻole koi ʻia he hoʻoponopono hoʻoponopono mua. ʻAʻole i hāʻawi ʻia ka hoʻohui pū ʻana o losartan-hydrochlorothiazide i nā maʻi maʻi i hemodialysis. ʻAʻole pono ke hui pū ʻana i ka losartan-hydrochlorothiazide i nā mea maʻi me ka maʻi koʻikoʻi o ka maʻi renaline (cleanine clearance

Pehea e hoʻohana ai: dosis a me ke ʻano o ka mālama ʻana

Loko, 1 ka manawa i kēlā me kēia lā, kahi manaʻo o ka meaʻai i ka meaʻai.

Me ka hypertension arterial, ʻo ka maʻamau mua a me ka mālama mālama pono ʻana i ka lāʻau lapaʻau he 1 pahu. LozarelR Plus 12.5 mg + 50 mg / lā.

I ka hana ʻole o ka hopena therapeutic kūpono i loko o nā hebedoma 3-4, pono e hoʻonui ʻia ka nui i loko o 2 papa o LozarelR Plus 12.5 mg + 50 mg a i 1 papa pāheʻi o LozarelR Plus 25 mg + 100 mg (nui i kēlā me kēia lā nui).

I ka poʻe maʻi me ka hoʻohaʻahaʻa nui o ke koko kahe koko (no ka laʻana, ʻoiai e lawe ana i nā koina nui o ka diuretics), ʻo ke ʻano loiloi mua o ka losartan e 25 mg hoʻokahi i ka lā. I kēia hiʻohiʻona, pono e hoʻomaka ʻia ʻo ke loio ma LozarelR Plus ma hope o ka hoʻokuʻu ʻana o ka diuretics a hoʻoponopono ʻia ka hypovolemia.

I nā poʻe maʻi a me nā mea maʻi me ka maikaʻi ʻole o ka hoʻololi ʻana i ka renal, me ka poʻe ma ka dialysis, ʻaʻohe koi mua o ka hoʻoponopono hoʻoponopono ʻia.

Ka hana lāʻau lapaʻau

ʻO Lozarel Plus kahi hui pū me kahi anagonistin II receptor antagonist (losartan) a me kahi diuretic thiazide (hydrochlorothiazide). ʻO ka hui pū ʻana o kēia mau māhele i kahi hopena antihypertensive hoʻohui a hōʻemi i ke koko (BP) i kahi kiʻekiʻe ma mua o kēlā me kēia māhele.

Hoʻohui

Me ka hoʻohana like ʻana o ka diuret thiazide me ka barbiturates, nā analcace narcotic, ka ethanol, kahi mahuahua nui o ka ulu ʻana i ka hypthension orthostatic hiki.

Hoʻololi ka diuretics i ka hoʻomaʻemaʻe o ka lithium a hoʻonui i ka hopena o ka hopena o nā meaʻawaʻawa, ʻo ka hui pū ʻana o ka diuretics a me ka hoʻomākaukau ʻana no ka lithium ʻaʻole ʻia.

Me ka hoʻohana like ʻana me ka presses amines (norepinephrine, epinephrine), hiki ke hōʻemi iki i nā hopena o ka presses amines, kahi e hoʻonāukiuki ai i kā lākou lawelawe, me nā hoʻomaha hoʻomaha non-depolarizing (tubocurarine) - kahi hoʻonui i ko lākou hopena.

Me ka hoʻohanaʻana o glucocorticosteroids, adrenocorticotropic hormone (ACTH), hiki ke hoʻonui i ka nalowale o nā electrolytes, hoʻonui i ka hypokalemia. Hiki i ka Thiazides ke hōʻemi i ka hoʻonui ʻana i nā waʻa a ka lāʻau cytotoxic a hoʻonui i kā lākou myelosuppressive hopena.

Nā ʻōlelo kikoʻī

ʻO nā hopena lā i loaʻa ka hopena iā RAAS (renin-angiotensin-aldosterone system) i nā mea maʻi me ka bilateral renal artery stenosis a i ʻole ka stenosis o hoʻokahi ʻōpala kūleʻa hiki ke hoʻonui i ka urea koko a me ka serum creatinine. ʻO nā hopena like ʻia me ka losartan. Ua hoʻohuli hou ʻia kēia mau lua o ka ʻaina a hala ma hope o ka hoʻokuʻu ʻana o ka ʻoihana. ʻAʻohe manaʻo aia i kekahi mau mea maʻi e lawe nei i ka lāʻau, ke hoʻohuli ʻia nei o nā loli i ka hana ʻana, me ka maikaʻi ʻole o ka hana ʻana, i hele mai ma muli o ka hoʻopio ʻana i ka hana RAAS.

E like me ka hoʻohana ʻana o nā lāʻau ʻē aʻe me ka hopena hypotensive, ma muli o ke kahe nui ʻana o ke kaomi koko i loko o ischemic cardiovascular a me cerebrovascular maʻi, hiki i ka myocardial infarction a me ka pōkole hiki i ke ulu.

I nā mea maʻi me ka hōʻeha ʻole o ka naʻau me ka ʻole o ka hana ʻole kīnā ʻole, hiki ke hōʻeha ʻia ka hoʻomaʻamaʻa ʻana a me ka hoʻoemi ʻana i ke koko.

E like me nāiotagonin II receptor angiotensin II, ʻaʻole i ʻoi aku ka maikaʻi o ka losartan i nā mea maʻi o ka lāhui Negroid, ka mea pili pū me ka hana haʻahaʻa haʻahaʻa.

I nā maʻi ma hope o ka hoʻololi ʻana i nā keiki, ʻaʻohe manaʻo me ka hoʻohana ʻana o losartan.

1. Nā hōʻailona no ka hoʻohana ʻana

ʻO ka lāʻau Lozarel e kauoha ʻia inā he:

Nā hōʻailona hōʻailona o ka hypertension.
ʻO ka hōʻemi o ka hopena o ka morbidity cardiovascular pili i ka poʻe e loaʻa ana i ka hypertension arterial a waiho ʻia nō hoʻi hypertrophy mai o ka ventricular, ka mea i hōʻike ʻia e ka hoʻohaʻahaʻa ʻana i loko o ka hui o ka maʻi cardiovascular, ʻeha a me ka myocardial infarction.
Hāʻawi i ka pale o ke keiki ma ka maʻi me nā maʻi diabetes type 2.
Ka pono e hoʻemi i ka proteinuria.
Hoʻopilikia ʻole ka puʻuwai hōʻeha me ka hoʻokele ʻole ʻana e ka ACE inhibitors.

3. Pili i nā mea lapaʻau

Hoʻopili ʻia ʻo Lazorel me nā lāʻau lapaʻau ʻē aʻe:

ʻAʻohe mea e hoʻopili ai ma waena o Lozarel a me Hydrochlorothiazide a me Digoxin, a me nā lāʻau ʻē aʻe e kū like ana i ka hopena o ke kanaka. I kekahi manawa ke hoʻohui pū me ia me "Rifampicin" a me "Fluconazole" alakaʻi i ka emi o ke kiʻekiʻe o ka metabolite hoʻoikaika i ka plasma koko.
ʻO ka hui pū me nā lāʻau lapaʻau e hoʻokaʻawale i ka enzyme angiotensin II a i kāna hana paha, nui ka hoʻonui nui ʻana o ka hōʻino o ka hoʻomohala ʻana o ka maʻi hyperkalemia.
ʻO nā lāʻau anti-inflammatory nonsteroidal hiki ke hoʻemi nui loa i ka hopena o nā mea blocker receptor II ka angensensin.
Hoʻohui pinepine ʻia nā mālama me nā angiotensin II antagonist receptor a me nā NSAID e hōʻeha pinepine i nā pilikia pilikia.
ʻO ka hui pū ʻana o ka antagonist reseptor angiotensin II me ka hoʻomākaukau ʻana o ka lithium e hoʻonui i ka nui o ka lithium i loaʻa i ka plasma koko.
Hana me ka "Losarel" i ka manawa like me ka hoʻolauna ʻana i nā diuretics e hāʻawi i kahi hopena hoʻohui. A ke hopena, loaʻa pū ka ʻokoʻa i ka pono o nā pono antihypertensive.

6. Nā huaʻōlelo a me nā kūlana kumu e waiho ai

Store ma kahi wela ʻaʻole oi aku 25 ° C. E hoʻomau i ka lāʻau lapaʻau i ka hiki ʻole o nā keiki liʻiliʻi.

ʻO ka lā kau ʻO ka lāʻau lapaʻau he 2 mau makahiki.

Mai hoʻohana i ka lāʻau lapaʻau ma hope o ka lā pau.

ʻO ke kumukūʻai o ka lāʻau Lazorel e like me ka mea hana a me ka ʻoihana o nā lāʻau lapaʻau, i Lūkia ka awelika kumukūʻai mai 200 rubles.

I Ukraine ʻaʻole pālahalaha ka lāʻau a pili ana ma kahi o 200 UAH.

Inā pono, hiki iā ʻoe ke hoʻololi i "Lozarel" me kekahi o kēia mau lāʻau lapaʻau.

Brozaar
Blocktran
Vero-Losartan
ʻO nā ʻōwili
Kālā-Sanovel
Zisakar
Keola
Karzartan
Lozap,
Lakea
ʻO Losartan A,
Canon Losartan
"Losartan potassium",
Mahalaloa Richter,
Nā Loli Makahiki,
Losartan Teva
"Lozartan-TAD",
Kālehu
Lorista
Presartan
Lotor
"Hoʻopau."

Hoʻohana nui ʻia ka hoʻohana ʻana o nā analogues no ka mālama ʻana i nā hihia i loaʻa ai i ka mea maʻi i ko lākou hoʻomanawanui pilikino i nā ʻāpana o ka lāʻau. Eia naʻe, hiki i ke kauka ke kuhikuhi i kekahi lāʻau lapaʻau.

Hiki i nā loiloi o ka lāʻau lapaʻau ke loaʻa ma ka Pūnaewele, no ka laʻana, e kākau ana ʻo Anastasia: "ʻO koʻu maʻi maʻi nui e hoʻomau i ka ʻeha. ʻAʻole i liuliu, ua kū wau me nā mea hou o kēia maʻi. Ua hōʻike pū ʻia au me ka nephropathy. Ua kuhikuhi aku ke kauka i kahi helu nui o nā lāʻau like ʻole, e like pū me Lozarel. ʻO ia kēlā i kōkua i ka wikiwiki e hoʻihoʻi maikaʻi i ka hana maʻamau o nā keiki. Ua nalo aku ka huki ʻana.

Hiki i nā ʻike ʻē aʻe i ka hopena o kēia ʻatikala.

ʻIke ʻia ka lāʻau ʻo Lozarel he lāʻau lapaʻau ka hopena i ka mālama ʻana i ka maʻi hypertension a me ka hopena ʻole o ka naʻau. Hoʻonui ʻia ia i nā kukuna o nā analogues me nā papa like like ʻole, ʻaʻole i hāʻawi ʻia no nā pilikia o ka puʻukū a me nā pōpoki, a ma ka wā hāpai a ma lalo o nā makahiki 18. No ka hōʻalo ʻana i ka hopena o nā hopena ʻaoʻao, ʻoi aku ia e lawe i ka lāʻau lapaʻau e like me ka mea a ke kauka.

Nā papa pālani, keʻokeʻo a ʻulaʻula paha i keʻokeʻo me kahi lepa melemele, hoʻopuni, biconvex, me ka pākē o kekahi ʻaoʻao.

Nā mea kūʻokoʻa: microcrystalline cellulose, lactose monohydrate, pregelatinized starch, anhydrous colloidal silicon dioxide, magnesium stearate.

ʻO ka hoʻonohonoho ponoʻī o ka membrane film: hypromellose, hyprolose, macrogol 400, titanium dioxide (E171), talc.

10 kamepiula - blisters (3) - nā ʻeke pepa.

He lāʻau lapaʻau antihypertensive, ke ʻano antagonist koho o nā ʻonikela II o ka angiotensin II (type AT 1). Hoʻopili a ʻo Angiotensin II i nā mea hoʻoponopono o ka AT 1 i ʻike i ka nui o nā koina (ma ka palupalu mākala kūpono o nā kīʻaha koko, nā kōkuhi adrenal, nā ʻōpū a me ka puʻuwai) a ke kumu i ka vasoconstriction a me ka hoʻokuʻu aldosterone, hoʻopihapiha i ka hoʻomaʻamaʻa ʻana o nā mākina palū.

Ma ka vitro a ma nā haʻawina vivo i hōʻike aku a losartan a me kāna mau laikini pharmacologically hoʻoikaika i nā hopena a pau o ka physiologically koʻikoʻi o ka angiotensin II, ʻaʻohe o ke kumu a me ke ala o kona synt synt. ʻAʻole ke keʻokeʻo i ka kinase II - he enzyme e hoʻopau ai i ka bradykinin.

Hoʻokuʻu ia i ka OPSS, ka piʻi ʻana o ke koko o ka ald testosterone, ka piʻi ʻana o ke koko, ke kaomi ana i ke kaomi pulmonary, e hōʻemi ana ma hope o ka lopa, he hopena diuretic. Kūleʻa ʻia me ka hoʻomohala ʻana o ka hypertrophy myocardial, hoʻonui i ka hoʻolahalaha ʻana i nā maʻi me nā maʻi ʻoi ʻole ka maʻi.

Ma hope o ka lawelawe waha hoʻokahi, ua emi ka hopena hypotensive (systolic a me ka diastolic blood pressure) a hiki i ka nui loa ma hope o 6 mau hola, a laila hoʻemi iki ʻia ma loko o 24 mau hola. Hoʻopilikia ka hopena hypotensive kiʻekiʻe ma 3-6 mau pule ma hope o ka hoʻokele mau ʻana i ka lāʻau.

ʻAʻole ia i ke pale aku i ka ACE a, no laila, ʻaʻole ia e pale i ka luku ʻana o ka bradykinin, no laila, ʻaʻole i loaʻa i ka losartan nā hopena like ʻole e pili pū me ka bradykinin (no ka laʻana, angioedema).

I nā mea maʻi me ka hypertension arterial me ka hapa ʻole o ka maʻi mellitus me ka proteinuria (ʻoi aku ʻoi aku ma mua o 2 g / lā), ka nui o ka hoʻohana ʻana i ka lāʻau lapaʻau he nui ka hoʻokaʻawale ʻana i proteinuria, ka ʻoihana o ka albumin a me ka immunoglobulins G.

Mālama i ka pae o ka urea i ka plasma koko. ʻAʻole pili i ka reflexes vegetative, a ʻaʻohe ona hopena ma ke ana o ka norepinephrine i loko o ke koko koko.

ʻO kahi hopena a hiki i ka 150 mg, 1 i ka manawa / lā ʻaʻole i hoʻopilikia i ka pae o ka triglycerides, ka nui o ka kolamu a me ka kolamu HDL (HD) i ka serum koko i nā maʻi nā mea maʻi me ka hypertension arterial. Ma ka hopena like, ʻaʻole pili ʻo losartan i ka wikiwiki o ka glucose koko.

I ka wā e lawelawe ʻia ana, e hoʻopili maikaʻi ʻia ka losartan mai ka papa ʻaina. Hana ia i ka metabolism i ka "papa mua" ma o ka ʻū ma ka carboxylation me ke komo ʻana o ka isoenzyme CYP2C9 me ka hoʻokumu ʻana o ka metabolite ikaika. ʻO ka bioavailability o ka'ōnaehana o losartan e pili ana i 33%. C max o losartan a me kāna hana metabolite e loaʻa ana i ka serum koko ma hope o kahi o 1 hola a 3-4 mau hola ma hope o ka hana ʻana, kēlā. ʻO ka ʻai ʻaʻole e pili i ka bioavailability o losartan.

Ke lawe nei i ka lāʻau lapaʻau ma o ka waha a hiki i ka 200 mg, losartan a me kāna hana metabolite e hōʻike ʻia e ka linear pharmacokinetics.

ʻO ka palena o ka losartan a me kāna hāmeʻa neʻe i nā protein plasma (ʻoi aku paha me ka albumin) ʻoi aku ma mua o 99%. V d losartan - 34 l. ʻAʻole ʻaʻole ʻo Losartan e komo i ka BBB.

Ma kahi o 14% o ka losartan e lawelawe ana i ka iv a ʻōlelo paha i ka mea maʻi e hoʻohuli ʻia i kahi metabolite ikaika.

ʻO ka wehe i ka plasma o ka losartan o 600 ml / min, ʻo ka metabolite kaha e 50 ml / min. ʻO ka hoʻomaʻamaʻa kino ʻole o ka losartan a me kāna metabolite kaola i ka 74 ml / min, a me 26 ml / min, kēlā. Ke hōʻike ʻia, ma kahi o 4% o ka nui i lawe ʻia e excreted e nā keiki i loli ʻole a ma kahi o 6% e hoʻopiʻi ʻia e nā keiki ma ke ʻano o kahi metabolite hoʻoikaika. Ma hope o ka lawelawe waha, ua hōʻemi ʻia ka plasma o losartan a me kāna hoʻohaʻahaʻa metabolite me ka hopena hope loa T 1/2 o losartan ma kahi o 2 mau hola, a me ka metabolite mau e pili ana i 6-9 mau hola. cumulate i loko o ke koko koko.

Hoʻokumu ʻia ʻo Losartan a me kāna mau metabolites ma o ka ʻōpū a me nā ʻili.

ʻO ka pharmacokinetics i nā hihia lapaʻau kūikawā

I ka poʻe maʻi me ka cirrhosis waiʻona maʻalahi, ʻo ka 5 ʻana o ka lilo ʻana o losartan, ʻo 5 mau manawa, a ʻo ka metabolite ikaika e 1,7 mau manawa ma mua o nā mea hana manawaleʻa kāne maikaʻi.

Me ka CC ma mua o 10 ml / min, ʻo ka neʻe o ka losartan i loko o ke koko koko ʻaʻole ʻokoʻa i kēlā me ia me ka hana maʻamau.I nā poʻe maʻi e koi ana i ka hemodialysis, ʻo ke kumukūʻai AUC ma kahi o 2 mau manawa e ʻoi aku ai i mua o nā maʻi i nā hana renal maʻamau.

ʻAʻole hoʻi ke kāʻili ʻia a losartan a me kāna metabolite ikaika mai ke kino ma o ka hemodialysis.

ʻO ka nānā ʻana o losartan a me kāna metabolite hoʻoikaika i ka plasma koko i nā kāne ʻelemakule me ka hypertension arterial ʻaʻole ʻokoʻa loa nā kumu o kēia mau ʻiliʻili i nā ʻōpio a me ka hypertension arterial.

ʻO nā waiwai o nā kukuna plasma o losartan i nā wahine me ka hypertension arterial he 2 mau manawa kiʻekiʻe ma mua o nā helu i pili i nā kāne e loaʻa mai ana i ka hypertension arterial. ʻOkoʻa nā ʻoliʻoli o ka metabolite ikaika i nā kāne a me nā wahine. ʻAʻole loaʻa i kēia ʻike koʻikoʻi nā lāʻau lapaʻau.

- ka huhū puʻuwai kūpilikiʻi (me ka loaʻa ʻole o ka mālama ʻana e nā ACE inhibitors),

- nephropathy i ka type 2 diabetes mellitus (hoʻemi i ka hōʻemi o ka hoʻomohala ʻana i ka hypercreatininemia a me ka proteinuria),

- hōʻemi i ka hopena o nā hoʻopiʻi a me ka make ma nā maʻi i nā maʻi me ka hypertension arterial a waiho aku i ka ventricular hypertrophy.

- lactation (umauma),

- makahiki a hiki i ka 18 makahiki (ʻaʻole i hoʻokū ʻia ka hana a me ka palekana),

- ka lactose intolerance, galactosemia a i ʻole glucose / galactose malabsorption syndrome,

- Kūpono o nā maʻi o ka lāʻau.

Me ka makaʻala, pono e hoʻohana ʻia ka lāʻau lapaʻau no ka maʻi hepatic a / a i ʻole ka hopena ʻole ʻana, he kahe i loko o ka bcc, ka wai kaulike me ka wai o ka electrolyte, a me ka stenosis bilateral renal stenosis a i ʻole ka stenosis o hoʻokahi artery kidney.

Ua kuhikuhi ʻia ka lāʻau lapaʻau i kahi manawa 1 ka manawa / lā, me ka nānā ʻole o ka meaʻai.

Me ka hypertension arterial i ka nui o nā hihia, ʻo ka hoʻomaka a me ka mālama mālama pono he 50 mg 1 manawa / lā. Inā kūpono, hiki ke hoʻonui ʻia ke ʻano o ka lāʻau lapaʻau ma 100 mg / lā i 1 a me 2 mau helu.

E pale i ke kiʻi o ka lawe ʻana i ka diuretics i nā dosis kiʻekiʻe, ua hoʻolako ʻia e hoʻomaka i ka lāʻau lapaʻau me ka mea hoʻopuka lozarel me ka 25 mg (1/2 tab. 50 mg) 1 manawa / lā.

Ma kahi hikiʻole i ka puʻuwai maʻamau, ʻo ka nui o ka lāʻau mua he 12.5 mg / lā, i ukali ʻia e ka hebedoma hoʻonui o 2 mau manawa i ka 50 mg / lā, e like me ka ʻoluʻolu o ka lāʻau. Ke hoʻohana ʻia i kahi mahele mua o 12.5 mg, ua paipai ʻia e hoʻohana i nā puka dosage me kahi haʻahaʻa o ka mea ikaika (25 mg nā papa me ka pilikia).

Ma ka type 2 diabetes mellitus me ka proteinuria (hoʻemi i ka hōʻemi o ka hoʻomohala ʻana i ka hypercreatininemia a me ka proteinuria), ʻo ke kiʻi mua loa he 50 mg 1 mau manawa / lā i 1 mau lāʻai. I ka wā o ka mālama ʻana, ma muli o ke kahe o ke koko, hiki iā ʻoe ke hoʻonui i kēlā me kēia lā o ka lāʻau i ka 100 mg i loko o ka 1 a me 2 paha nā koina.

Ke hoʻohana nei i ka lāʻau Lozarel i mea e hōʻemi ai i ka hopena o ka hoʻomohala ʻana i ka hoʻopiʻi cardiovascular a me ka make ma ka poʻe maʻi me ka hypertension arterial a waiho aku i ka hypertrophy ventricular, ʻo ka pā mua ma mua o 50 mg 1 mau lā / lā, inā pono, hiki ke hoʻonui ʻia ka nui i 100 mg / lā.

ʻO ka poʻe maʻi me ka hana renal impaired (CC ma lalo o 20 ml / min), me ka mōʻaukala o ka maʻi ate, ka huhū, ma ka hana ʻana o ka dialysis, me nā mea maʻi ʻoi aku ka 75 makahiki o ke kumu, ua noi ʻia e kuhikuhi i ka lāʻau i loko o kahi haʻahaʻa mua o ka haʻahaʻa - 25 mg (1/2 tab. 50 mg) 1 manawa / lā.

ʻO ka maʻamau, nā hopena ʻoluʻolu a me ka palu, ʻaʻole pono e hoʻokuʻu i ka mālama ʻana.

ʻŌpū a me ka lactation

ʻAʻole i kuhikuhi ʻia ʻo Lozarel Plus i ka wā hāpai ʻia / lactation.

I ka wā e hoʻohana ai i ka lāʻau lapaʻau i ka mea hoʻoponopono o II - III trimesters no ka hapaha, hiki ke hōʻeha ka mea i hoʻoulu ʻia ai ka maʻi fetolo, ma kekahi mau mea, hiki i ka lāʻau ke mālama i kona make. Hoʻonui pū ka hopena o kēia mau pilikia i lalo o ka pūpū: jaundice a me ka jaundice o ka pēpē. Hiki i ka makuahine ke kūkulu i ka thrombocytopenia. Pono e kāpae ʻia ʻo Lozarel Plus ma hope o ka hōʻoia o ka hāpai ʻana.

I ka loiloi ʻana i nā pono a me nā pilikia o ka hoʻohana ʻana iā Lozarel Plus, e noʻonoʻo pono nā wahine hānai ʻana i ka thiazides e hoʻopili ʻia i loko o ka waiū umauma, ʻaʻole i aʻo ʻia ka ʻike palekana o losartan. Inā pono e hoʻohana i ka Lozarel Plus, pono keʻakeʻa ka umauma.

Me ka hana pūnāwai paʻa ʻole

I nā maʻi me ka hōʻeha o ka renal nui (CC ma mua o 30 ml / min), ua mālama ʻia ka lāʻau lapaʻau.

Me ka maikaʻi ʻole o ka renal mod ole (CC 30-50 ml / min), i ʻōlelo ʻia ʻo Lozarel Plus me ka akahele.

ʻAʻole koi ʻia ka hoʻoponopono ʻana o ka maʻi mua i nā mea maʻi me ka maikaʻi ʻole o ka renal, me ka poʻe ma ka dialysis.

Me ka hana pūpū hemahema

No ka poʻe maʻi me ka maʻi hepatic koʻikoʻi (e like me ke ʻano o ke keiki-Pugh ma mua o 9 mauʻaoʻao), ka maʻi me kēia hui antihypertensive hui pū.

Me nā maʻi o ka pūliki holomua a me ka hana hepatic maʻi i ʻole ka liʻiliʻi ma mua o ka 9 mau poina ma ka laulima keiki-Pugh Lozarel Plus, hoʻohana ʻia ia ma lalo o ka mākaʻi loea.

Ka hoʻonohonoho ʻana a me ke ʻano o ka hoʻokuʻu ʻana

Kuhi ʻia ka lāʻau lapaʻau ma ke ʻano o biconvex, nā ʻāpana lapuwale, i kālai ʻia me ka ʻāpana melemele kukui. Inā ʻoe e uhaʻi i ka papa i 2 mau ʻāpana, a hiki ke ʻike i kahi papa keʻokeʻo a keʻokeʻo paha-keʻokeʻo. Aia i kēlā me kēia pūpū he 30 mau papa.

E like me nā mea hana, hiki i ka lāʻau lapaʻau ke loaʻa nā loko o 12.5 mg o ka hydrochlorothiazide a me 50 mg o ka potassium losartan a i ʻole 25 mg o ka hydrochlorothiazide a me 100 mg o ka pāhare losartan.

ʻO ka kumu hoʻohālikelike o Lozarel Plus ka lactose monohidate, ka pregelatinized starch, MCC, colloidal silicon dioxide, magnesium stearate.

Kūkulu ka lāpana i ka pua hao hao melemele (wai), hyprolose, titanium dioxide, hypromellose.

Lozarel: nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana, ke kumukūʻai, nā hoʻohālikelike

ʻO Lozarel kahi puʻuwai koko e hoʻohaʻahaʻa ana i ka lāʻau lapaʻau e hoʻohana nui ʻia ana i ka mālama ʻia ʻana o ka poʻe me ka hypertension arterial, hōʻeha puʻuwai, a me ka maʻi maʻi (e pale aku i nā keiki). E like me nā lāʻau ʻē aʻe, loaʻa kekahi mau hōʻailona, contraindications a me nā hopena paha.

Nā kūlana, lōʻihi o ka waiho ʻana

E kūʻai ma Lozarel Plus i ke mahana a hiki i ka +25 tikelika no ʻelua mau makahiki ʻelua.

I nā kānaka o Rūsia kāʻei i kahi lāʻau lapaʻau ke kumukūʻai ma 200-300 rubles.

Kuhi kumukūʻai Lozarel Plus i Ukraine - 240 hryvnia.

ʻO nā hui o nā lāʻau lapaʻau nā lāʻau like ʻole e like me Lozartan N, Simartan-N, Lozartan-N Canon, Presartan N, Lorista ND, Lorista N.

Ma ka hoʻoponopono ʻana i nā loiloi, hoʻomaikaʻi maikaʻi ʻo Lozarel Plus i ke kahe o ke koko a kōkua maikaʻi i ka mokuʻāina o ka ʻōnaehana cardiovascular.

Wahi a nā kauka ʻaʻole pono ia nā lāʻau lapaʻau no nā maʻi maʻi hypertensive āpau, no laila pono lā ʻoe e lawe i ka ʻōlelo a ke kauka.

Hiki iā ʻoe ke heluhelu i nā loiloi i waiho ʻia e nā kānaka maoli ma ka hopena o nā ʻōlelo o ka ʻenemi.

Nā ʻōkuhi no ka hoʻohana

Wahi a nā ʻōkuhi no ka hoʻohana ʻana, lawe maʻamau ka lāʻau i hoʻokahi manawa i ka lā. A hana lākou ʻelua ma ke ʻōpū ʻole, a ma hope o ka ʻai ʻana.

Ke mālama nei i ka hypertension, ʻo ka nui a me ka hopena ma hope he 50 mg hoʻokahi i ka lā. Me ka hopena hikiʻole, ke hoʻonui ʻia ka hewa i 100 mg i kēlā me kēia lā (inā makemake ʻia, hiki ke hoʻokaʻawale ʻia i ʻelua pūmole).

I ka mālamaʻana i ka hana o ka puʻuwai hōʻeha, ʻo ka nui ma mua o ka nui o 12.5 mg (kahi hapahā o ka papaʻaina) i kēlā me kēia lā, ukali ʻia e ka piʻi ʻana (e pālua ʻia ka nui i kēlā me kēia pule). ʻOi aku ma mua o 50 mg ʻaʻole pono e lawe ʻia i kēlā me kēia lā.

No ka hōʻemi i ka hopena o ka hoʻolālāʻana i ka hypercreatininemia a me ka proteinuria i nā mea maʻi me ka diabetes mellitus type 2, e hoʻomaka ana ka mālama ʻana me ka lāʻau lapaʻau me 50 mg hoʻokahi i ka lā. Ma hope aku, hoʻonui ʻia ke ʻano o kēlā me kēia lā (me ka hopena maikaʻi ʻole) i 100 mg i lawe ʻia i hoʻokahi mau ʻia ʻelua.

No ka hōʻemi ʻana i ka pilikia o nā hoʻopiʻi cardiovascular a me ka make i loko o nā poʻe me ka hypertension arterial a me ka hoʻopaʻapaʻa ʻana o ka paia hema hema, hoʻomaka ʻia ka mālama ʻana me 50 mg hoʻokahi i ka lā. Inā pono, e hoʻonui i ka momona i 100 mg i kēlā me kēia lā.

ʻAno ʻia kahi kau palena haʻahaʻa (25 mg i kēlā me kēia lā).

ma luna o ka 75 makahiki aku
e pilikia ana mai ka lūlū, nā aʻalolo a me nā maʻi āpau,
aia ma ka huakini.

Hoike ʻia ma Lozarel

“I loaʻa iaʻu kahi pilikia o ka puʻuwai ʻelima mau makahiki i hala. Ua hoʻāʻo wau e kokoke i nā mea āpau o ACE, akā aneane ʻaʻole i ʻike i nā loli maikaʻi. A laila ua kuhikuhi ke kauka iaʻu iā Lozarel. ʻO ke ala ke lawe ʻia ʻana, hoʻomaka ʻo ia e ʻike ua ʻalā, a laila ua emi ka nui o ke kuʻi ʻana i kona mau wāwae a me nā lima, a laila nalowale loa ka pōkole o ka hanu. ʻAʻole hoʻomaka ka lāʻau lapaʻau e hana koke, akā, ʻoi aku ka lōʻihi o ka lawe ʻana, ʻoi aku ka nui o ka hopena. Ma hope o ʻelima mau lā o ka lawe ʻana, hoʻonā wau i kahi pōkole hoʻonāukiuki pōkō, a i kēia manawa ke hiki iaʻu ke kaena i ka nawaliwali a me ka pākuʻi ʻana. ʻAe, ʻaʻole maopopo mai ka pōkole o ka hanu "