ʻO ka paukū Amoxiclav no ka hoʻokuʻuʻana i ka 400 mg 57 mg

ʻO Amoxiclav ® kahi hui o amoxicillin - penicillin semisynthetic me kahi ākea o ka hana antibacterial a me ka clavulanic acid - kahi pale lipi e hoʻihoʻi ʻole o β-lactamases. Hoʻokomo ka hoʻohuihui Clavulanic i kahi paʻakikī paʻa ʻole i kēia mau enzyme a me ka hōʻoia i ka kūʻē o ka amoxicillin i nā hopena o nā β-lactamases i hoʻolālā ʻia e microorganisms.

ʻO ka mole Clavulanic, like me ka hana i ka antibiotics beta-lactam, he hana intrinsic antibacterial nāwaliwali.

Loaʻa i ka Amoxiclav ® kahi ākea ākea o ka hana antibacterial.

Kākoʻo kūʻē ʻO Amoxicillin-sensitive strains, me ka β-lactamase e hana ana i nā uaua, a me nā aerobic gram-maikaʻi bacteria: Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus viridans, Streptococcus bovis, Staphylococcus aureus (koe wale nō nā moku-kū a me ka methicillin-kū'ē), Staphylococcus epidermidis (koe wale nō iā Staphylococcus saprophy), aerobic gram-negative bacteria: Bordetella pertussis, Brucella spp., Campylobacter jejuni, Escherichia coli, Gardnerella vaginalis, Haemophilus influenzae, Haemophilus ducreyi, Klebsiella spp., Moraxella catarrhalis, Pippis neisseria gonorrhoeae Somppella meppida meisseria ʻO Vibrio cholerae, Yersinia enterocolitica, Helicobacter pylori, Eikenella corrodens, anaerobic gram-positive bacteria: Peptococcus spp., Peptostreptococcus spp., Clostridium spp., Actinomyces israelii, Fusobacterium spp., Prevotella spp., gram-ana anaobobes ʻO nā Bacteroides spp.

Lapaʻau lāʻau

ʻO nā hiʻohiʻona nui o ka pharmacokinetic o ka amoxicillin a me ka acid clavulanic i like.

ʻEleʻa maikaʻi nā māhele ʻelua ma hope o ka lawe ʻana i ka lāʻau lapaʻau i loko, ʻaʻole e hoʻopilikia i ka pae o ke kao ʻana. C_max i loko o ke kō koko pili ʻia 1 ka hola ma hope o ka hoʻokele ʻana. ʻĀina C_max kia ala no ka amoxicillin (ma muli o ke ʻano) 3-12 μg / ml, no ka wai clavulanic - e pili ana iā 2 μg / ml.

Hōʻike ʻia nā ʻaoʻao ʻelua i ka nui o ka hoʻoili ʻana i nā ʻōmole o nā kino a me nā ʻōpio (pūpū, nā pepeiao waena, nā pleural a me nā peritoneal wai, ka ʻōpū, ka ovaries, a me nā mea pono). Ma Amoxicillin komo i ka wai synovial, ate, prostate gland, palatine tonsils, kiko o ka ʻōpū, ka puʻuwai ʻana, nā mea huna o nā sinuses, ka lawaiʻa, nā mea huna huna bronchial.

ʻO Amoxicillin a me clavulanic acid ʻaʻole i komo i ka BBB me ka meninges uninflamed.

ʻO Amoxicillin a me clavulanic acid e hoʻowalewale i ka pale o ka placental a ma o ka nui o nā wahi i hoʻopili ʻia i loko o ka waiū umauma. Hōʻikeʻo Amoxicillin a me clavulanic acid i ka hoʻohaʻahaʻa haʻahaʻa i nā protein plasma.

Amoxicillin i hoʻoneʻe ʻia i ka ʻaoʻao, clavulanic acid ua hoʻopiʻi ʻia i ka metabolism ikaika.

Hoʻopili ʻia ʻo Amoxicillin e nā keiki i aneane e loli a ka huna ʻia o ka tubular a me ka filtration glomerular. Hoʻokumu ʻia ka hoʻohuihui Clavulanic e ka filtration glomerular, ma kahi ʻāpana i nā metabolites. Hiki ke hoʻopaneʻe ʻia ka liʻiliʻi ma o nā ʻōpū a me nā ʻōpū. T_1/2 amoxicillin a me ka clavulanic acid he 1-1,5 hola

ʻO ka pharmacokinetics i nā hihia lapaʻau kūikawā

I nā hopena hoʻokū ākea T_1/2 hoʻonui i 7.5 mau hola no ka amoxicillin a i hiki i nā hola 4 no ka clavulanic acid. Hoʻokuʻu ʻia nā ʻaoʻao ʻelua i ka hemodialysis a me nā helu liʻiliʻi e nā dialysis peritoneal.

Nā maʻi ʻeha e hōʻake ʻia e nā ʻōpala hikiʻole i nā microorganisms:

- nā maʻi o ka ʻōpū hanu o luna a me nā mea komo ENT (e pili ana i ka sinusitis a me ka maʻi sinusitis, nā hopena a me ka maʻi otitis media, ka maʻi o ka pharyngeal, tonsillitis, pharyngitis),

- nā maʻi o ka ʻōpū o ka ʻōpū o ka haʻahaʻa (e komo pū ana me ka bronchitis nui me ka superinfection bakalula, bronchitis maʻi, pneumonia),

ʻAʻohe maʻi ʻeha

- ka hana ʻana o ka ʻili a me nā ʻili palupalu, e komo pū ai nā holoholona a me ke kanaka.

- nā maʻi o ka iwi a me ka pili,

- nā maʻi o ka biliary tract (cholecystitis, cholangitis),

Nā Hoʻohui

- Kūpono o nā maʻi o ka lāʻau,

- Hypersensitivity i ka mōʻaukala i nā penicillins, cephalosporins a me nā antibiotika beta-lactam,

- ka mōʻaukala o nā hōʻailona o ka jaundice cholestatic a me / a i ʻole nā hana ʻē aʻe i hoʻopili ʻia e ka hoʻokele o ka amoxicillin / clavulanic acid,

- E loaʻa ana nā maʻi mononukleosis a me nā maʻi lepa lymphocytic.

Me ka akahele pono e hoʻohana ʻia ka lāʻau me ka mōʻaukala o ka colitis pseudomembranous, me ka hana ʻole o ka puʻuwai, hōʻeha kino ʻole o ka pūpū, a i ka wā o ka lactation.

Nā hopena hopena

ʻO nā hopena ʻaoʻao ma ka hapanui he mau māmā a transient.

Mai ka pūnaehana hana ʻana: ka nalo ʻana o ka momona, ka ʻuwelau, ka luaʻi ʻana, ke ʻehaʻeha, ke ʻeha o ka ʻōpū, ke ake ʻana o nā hana ʻalopona, ʻoi aku ka nui o nā ʻalohi o nā ate (ALT a i AST), i nā hihia kaʻawale - jaundice cholestatic, hepatitis, colse pseudomembranous.

Nā maʻi kūwaha: pruritus, urticaria, erythematous rash, jarang - multiforme exudative erythema, angioedema, anaphylactic shock, vasculitis allergic, i nā hihia luhilahi - dermatitis exfoliative, sindrom Stevens-Johnson, ulana pākula exanthematous maʻamau.

Mai ka pūnaehana hemopoietic a me ka ʻōnaehana lymphatic: leukopenia lohi (hiki i ke neutropenia), thrombocytopenia, luhi pinepine loa - hemolytic anemia, hoʻoliʻi ka piʻi ʻana i ka manawa prothrombin (i ka wā i hui pū me ka anticoagulants), eosinophilia, pancytopenia.

Mai ka ʻōnaehana hoʻonāukiuki: ʻeha, hōʻeha, kaumaha loa - hōʻino (hiki i nā mea maʻi ke hōʻeha i ka hana renal impaired i ka wā e lawe ai i ka lāʻau lapaʻau i nā wā kiʻekiʻe), hyperactivity, hopohopo, hopohopo.

Mai ka urinary system: ākea loa - interstitial nephritis, crystalluria.

Nā ʻili: kaliki - ka ulu ʻana o superinfection (me ka candidiasis).

Ke keu

ʻAʻohe mau hōʻike e pili ana i ka make a i ke ola e pili ana i ka hopena ma muli o ka make nui o ka lāʻau.

Nā Hoʻomaka i nā manawa maʻamau, nā pilikia o ka haki o ka gastrointestinal (hōʻeha o ka ʻōpū, ka ʻōpū, ka luaʻi)

Lāʻau: ma ka mea maʻi me lalo o ka mālama ʻana i ka lāʻau lapaʻau, ʻike maʻi. Ma ka hihia o kēia hana o ka lāʻau lapaʻau (ma mua o 4 mau hola), pono e holoi i ka ʻōpū a hoʻonā i nā ulana i hoʻolaʻa ʻia e hōʻemi ai i ka lilo ʻana o ka lāʻau. Hoʻokuʻuʻia ka amoxicillin / potassium clavunate e ka hemodialysis.

Nā ʻōlelo kikoʻī

Me kahi papa o ka mālama ʻana, e nānā pono ʻia nā hana o ke koko, ka ate a me nā ʻōpū.

I nā mea maʻi me ka hana renal impaired koʻikoʻi, kahi hoʻoponopono kūpono o ka dimen regimen a i ʻole he piʻi ʻana ma waena o ke dosing pono.

I mea e hōʻemi ai i ka hoʻopau ʻia o nā hopena ʻino mai ka gastrointestinal tract, pono ke lawe ʻia ka lāʻau lapaʻau me ka ʻai.

Hana i nā hoʻokolohua Laboratory: hāʻawi ʻoi i ka nui o ka hakuxicillin i ka hopena maikaʻi ʻole i ka glucose i ka wai i ka wā e hoʻohana ai i ka hopena o Benedict a i ʻole ka hopena a Felling. Hoʻomaopopo ʻia nā ʻano hopena Enzymatic me ka glucosidase.

Hoʻokomo i ka hiki ke lawe i nā kaʻa a kāohi i nā mīkini

ʻAʻohe ʻikepili e pili ana i ka hopena maikaʻi loa o Amoxiclav i nā makemake i ʻōlelo ʻia i ka hiki ke lawe i kahi kaʻa a hana paha me nā mīkini.

Hoʻohui nūhou

Me ka hoʻohana like ʻana o ka lāʻau ʻAoxiclav ® me nā antacids, glucosamine, laxatives, aminoglycosides, hoʻopihapiha iho nā mea a pau, me ka acid ascorbic - hoʻonui.

Diuretics, allopurinol, phenylbutazone, NSAIDs a me nā lāʻau lapaʻau ʻē aʻe e poloka ana i ka ʻōlelo huna tubular e hoʻonui i ka pehu o ka amoxicillin (clavulanic acid e hoʻōla nui ʻia e ka glomerular filtration).

Me ka hana like o Amoxiclav ® e hoʻonui i ka pehu o ka methotrexate.

Me ka hoʻohana like ʻana o Amoxiclav me allopurinol, ke hoʻonui nui nei ka ulu o ka exanthema.

ʻO ka hui lawelawe me ka disulfiram e hōʻalo.

I kekahi mau mea, lawe ka lāʻau lapaʻau e hiki ke hoʻolōʻihi i ka manawa prothrombin, i kēia mea, pono e hoʻomaʻamaʻa ʻia i ka wā e kuhikuhi ana i nā anticoagulants a me ka lāʻau lapaʻau Amoxiclav ®.

ʻO ka hui pū ʻana o ka amoxicillin me rifampicin he antagonistic (aia kekahi mauwaliwali ʻana o ka hopena antibacterial).

ʻAʻole pono e hoʻohana ʻo Amoxiclav ® i ka manawa like me nā antibiotika bacteriostatic (macrolides, tetracyclines), sulfonamides ma kahi o kahi hiki ke emi i ka hopena o Amoxiclav.

Hoʻopala ka Probenecid i ka hoʻonuiʻana i ka amoxicillin, e hoʻonui ana i kona koʻikoʻi serum.

Hoʻemi ka poʻe antibiotics i ka hopena o nā mea hoʻohālikelike waha.

Ke ʻano o ka noi

Nā lā inanima o nā lā a pau 125 mg + 31.25 mg / 5 ml a me 250 mg + 62.5 mg / 5 ml (i mea e hōʻoluʻolu ai i ka hiki ʻana o nā puhīkī o 125 mg + 31.25 mg / 5 ml a me 250 mg + 62.5 mg / 5 ml o ka hoʻokuʻu manawa i kēlā me kēia pākeke, kahi wai kīnā me ka nui o 5 ml a i ʻole ka mea i hoʻoliʻi ʻia i kahi pulu hoʻoleʻa i hoʻopili ʻia.

ʻO nā keiki a me nā keiki a hiki i 3 mau mahina koho 30 mg / kg (amoxicillin) / lā, i mahele ʻia i 2 mau pona (i kēlā me kēia mau hola 12). kamaliʻi i nā mahina o 3 mau mahina - mai 20 mg (amoxicillin) / kg / lā ma nā maʻi maʻamaumālie i ke kaumaha maʻalahi a i ka 40 mg / kg (e like me amoxicillin) / lā ma maʻi pākuʻi a me ka hoʻopā ʻana māhele ʻia i 3 mau pona (i kēlā me kēia 8 mau hola).

ʻO ke ʻano o nā pona i hāpai ʻia ma ke ʻano o ke kino o ke keiki a me ka nui o ka maʻi.

Kauka kino (kg)	Nā ʻōpio (kahi kokoke)	Nā maʻi haehae / paleha ʻia		ʻO nā maʻi koʻikoʻi
Kauka kino (kg)	Nā ʻōpio (kahi kokoke)	125 mg + 31.25 mg / 5 ml	250 mg + 62.5 mg / 5 ml	125 mg + 31.25 mg / 5 ml	250 mg + 62.5 mg / 5 ml
5-10	3-12 mahina	3 × 2,5 ml (1 /₂ l.)	3 × 1.25 ml (1 /₄ l.)	3 × 3.75 ml (3 /₄ l.)	3 × 2 ml (1 /₄- 1 /₂ l.)
10-12	1-2 mau makahiki	3 × 3.75 ml (3 /₄ l.)	3 × 2 ml (1 /₄- 1 /₂ l.)	3 × 6.25 ml (1 1 /₄ l.)	3 × 3 ml (1 /₂- 3 /₄ l.)
12-15	2-4 makahiki	3 × 5 ml (1 l.)	3 × 2,5 ml (1 /₂ l).	3 × 7.5 ml (1 1 /₂ l.)	3 × 3.75 ml (3 /₄ l.)
15-20	4-6 makahiki makahiki	3 × 6.25 ml (1 1 /₄ l.)	3 × 3 ml (1 /₂- 3 /₄ l.)	3 × 9.5 ml (1 3 /₄-2 l.)	3 × 5 ml (1 l.)
20-30	6-10 mau makahiki	3 × 8.75 ml (1 3 /₄ l.)	3 × 4.5 ml (3 /₄-1 l.)	-	3 × 7 ml (1 1 /₄-1 1 /₂ l.)
30-40	10-12 mau makahiki	-	3 × 6.5 ml (1 1 /₄ l.)	-	3 × 9.5 ml (1 3 /₄-2 l.)
≥ 40	≥ 12 mau makahiki	Ua kuhikuhi ʻia ʻo Amoxiclav ® i nā papa

ʻO nā helu i kēlā me kēia lā i ka hoʻokuʻuʻana i ka 400 mg + 57 mg / 5 ml kau helu ia ka 1 kg o ke kino o ke kino ma muli o ka nui o ka maʻi a he 25-45 mg / kg kino kino / lā (ma nā ʻōlelo o ka amoxicillin), i hoʻokaʻawale ʻia i 2 dosis.

No ka hoʻomaʻamaʻa i nā dosa kūpono, ua kau ʻia kahi pēpē he 400 mg + 57 mg / 5 ml i kēlā me kēia paena o ka pipette dosage, hoʻopau ʻia i ka manawa like i ka 1, 2, 3, 4, 5 ml a me nā māhele like 4.

No ke ʻano o ka pohō ʻana o ka hoʻopiʻi ʻana ma muli o ke kino o ke keiki a me ka nui o ka maʻi.

Kauka kino (kg)	Nā ʻōpio (kahi kokoke)	ʻO nā maʻi koʻikoʻi	Nā maʻi maʻi molo
5-10	3-12 mahina	2 × 2.5 ml (1 /₂ ʻōpio	2 × 1.25 ml (1 /₄ ʻōpio
10-15	1-2 mau makahiki	2 × 3.75 ml (3 /₄ ʻōpio	2 × 2.5 ml (1 /₂ ʻōpio
15-20	2-4 makahiki	2 × 5 ml (1 pipette)	2 × 3.75 ml (3 /₄ ʻōpio
20-30	4-6 makahiki makahiki	2 × 7.5 ml (1 1 /₂ ʻōpio	2 × 5 ml (1 pipette)
30-40	6-10 mau makahiki	2 × 10 ml (2 pipettes)	2 × 6.5 ml (1 1 /₄ ʻōpio

Hoʻoholo ʻia nā dole kūpono i kēlā me kēia lā ma ke paona o ke keiki, a ʻaʻole ʻo kona makahiki.

ʻO ka palena loa o ka lā maʻamau no ka amoxicillin no o nā pākeke 6 g no keiki - 45 mg / kg kaumaha kino.

Ka loa momona o kēlā me kēia lā no ka clavulanic acid (ma ke ʻano o ka paʻakai pākela) no o nā pākeke 600 mg no keiki - 10 mg / kg paona ke kaumaha.

I nā mea maʻi me ka maikaʻi ʻoi aku ka maikaʻi (CC ma mua o 10 ml / min) Pono e hōʻemi ʻia ka nui o ka hopena a ʻo nā lā ma waena o nā inikua ʻelua e hoʻonui (me anuria a hiki i 48 mau hola a keu paha).

ʻO ke ala e mālama ai i nā lā 5-14. Hoʻoholo ʻia ka lōʻihi o ke ʻano o ka mālama ʻana e ke kauka hele mai. ʻAʻole pono e hānai ʻia ʻoi aku ma mua o 14 mau lā inā ʻaʻole e hoʻopaʻa loiloi i ka lua.

Na rula no ka hoʻomākaukau ana o ka hāpai ʻana

ʻO ka pauka no ka hoʻomākaukau ʻana o ka hoʻomaha o ka 125 mg + 31.25 mg / 5 ml: lulu ikaika i ka omole, hoʻohui iā 86 ml wai (i ka hōʻailona) i ʻelua mau pona, kēlā me kēia manawa e lulu pono a hiki i ka pau ʻana o ka pauka.

ʻO ka pauka no ka hoʻomākaukau ʻana o ka pohō o ka 250 mg + 62.5 mg / 5 ml: lulu ikaika i ka omole, hoʻohui i ka 85 ml wai (i ka hōʻailona) i ʻelua inikua, kēlā me kēia manawa ka lūlū maikaʻi a hiki i ka pau ʻana o ka pauka.

ʻO ka pauka no ka hoʻomākaukau ʻana o ke kāpena o ka 400 mg + 57 mg / 5 ml: ikaika ikaika i ka hue, hoʻohui i ka wai i ka nui i hōʻike ʻia i ka hōʻailona a hōʻike ʻia i ka papaʻaina (i ka māka) i ʻelua mau pona, i kēlā me kēia manawa e hiolo maikaʻi a hiki i ka pau ʻana o ka pauka.

ʻOkoʻa nui	Ka mea e pono ai ka wai
35 ml	29.5 ml
50 ml	42 ml
70 ml	59 ml
140 ml	118 ml

Ma mua o ka hoʻohana ʻana, pono e lulu nui ka kīʻaha.

Amoxiclav: mea hoʻonohonoho a me nā hōʻike no ka hoʻohana

ʻO Amoxiclav kahi hoʻohui i hoʻohui ʻia e hiki ke lawe i ka maʻi like ʻole, e hoʻomaka ana me ka bronchitis a hoʻopau i nā pilikia o ka pēpē. ʻO nā mea ikaika o ka lāʻau lapaʻau ka:

ʻO nā mea hoʻohui o Amoxiclav e loaʻa:

Na citrate
citric acid
laulaja popula
Na benzoate,
colloidal silicon dioxide,
lepa Nah,
Na Kahu
ʻāmi ʻono (cherry, strawberry, lemon),
mannitol.

Hoʻokomo ʻia nā antibiotics inā inā ʻo ke kumu o ka maʻi he maʻi huʻopiʻi maikaʻi ʻole. Hoʻomaʻamaʻa ʻia ʻo Amoxiclav no nā keiki a me nā pākeke no ka maʻi ʻana o ka ʻōpū kūkulu ʻana a me ka haʻahaʻa o ka ʻōpū a me ka ola ENT. Hoʻopili ʻia nā hana ʻōnaehana:

Nā lau ahe (tonsilitis),
sinusitis aʻai ʻole
media otitis media
pharyngitis
pirelonephritis,
hopohopo lealea,
sinusitis
ʻOluomini
wahi maʻi pneumonia

No ka mea, ʻoi aku ka hoʻohana ʻana i kahi mea maʻi i ka hihia i loko o ka hihia:

Ke ʻano o ka hoʻokuʻu ʻana: nā hana a me nā papa

Hāʻawi ka ʻoihana farmacological i ka mea kūʻai aku i ʻelua mau ʻano o ka hoʻokuʻu i ka lāʻau antibacterial. ʻO nā mea hōʻola. He kūpono no nā pāloʻi. ʻO ka mea pōmaikaʻi nui o kēia puka mea maʻalahi nā papa e hoʻohana i nā wahi a pau, e nānā ana i ka hoʻoponopono o ka hoʻokomo. Loaʻa lākou ma nā kaila o 250 a me 500 mg o ka amoxicillin a me 125 mg o ka clavulanic acid. I kahi e wili - 15 a 20 mau papa.

ʻO ke ʻano ʻelua o ka hoʻokuʻu ʻana, ʻo ka paukeke kahi i mākaukau ai ka pāpā ʻia. Eʻoi aku ka maikaʻi o kahi keiki e loaʻa i nā amoxiclav i kēia ʻano, no ka poʻe ʻike ʻole mau pehea e hoʻokaʻa a ʻai paha i nā papa.

Hōʻike ka papa ma lalo nei i nā hoʻomoʻala e hoʻohālikelike ʻia ai ke pauma o Amoxiclav no nā keiki:

ʻO ka huina piha ma 5 ml o ke kali ʻana, mg	ʻO ka waiwai o ka amoxicillin, mg	ʻO ka wai o ka waikawa clavulanic, mg
125	125	31,25
250	250	62,5
400	400	57

ʻO ka keʻokeʻo a paʻa paha ka mākaukau i keʻokeʻo a ʻeleʻele paha. Loaʻa ka huahana i nā pahu aniani a me ka poli o 100 ml. I loko o kahi pahu momona o 25 mau poli. ʻO ka mākeke i paʻa me kahi ipu hao a pipette paha. Pehea e hoʻomākaukau ai i kahi pīhoihoi, hiki iā ʻoe ke heluhelu i nā kuhikuhi i hoʻopili ʻia a nānā i ke wikiō no ka ʻatikala me kahi paiel o kahi hana i hana ʻia e ka laʻi.

Pehea e helu ai i ka helu o ka lāʻau?

E hoʻokō i kahi hopena maikaʻi wikiwiki mai ka lawe ʻana i ka antibiotic a me ka hōʻemi ʻana i ka hopena o ka hopena o ka hoʻopiʻi, pono ʻoe e hoʻoholo i ka pae o ka lāʻau a hoʻōla kūpono a hāʻawi i ke keiki i kahi papa a i ʻole nā papa e inu.

No ka helu pololei ʻana i ka lawelawe ʻana iā Amoxiclav, pono e noʻonoʻo ʻia nā mea aʻe:

makahiki hānau pēpē
kaumaha o kahi mea maʻi liʻiliʻi
maʻi kikoʻī
ka nui o ka maʻi.

No nā keiki mai ʻelima mau mahina a ʻumi mau makahiki me ka ʻōpū maʻamau o ka papa o ka maʻi infectious, ua lawa ia e hoʻomoʻa i ka pauka me kahi dosis o 125 mg. Inā paʻakikī ka panghina, ʻo ka maʻi ʻaila a i ʻole nā māla ʻē aʻe, a laila e hoʻokaʻawale ʻia ka lāʻau hoʻōla me kahi mea ikaika a antibacterial ma ka nui o 250 a 400 mg paha.

I ka hoʻokuʻuʻana - no nā keiki he ʻumikumamālua o kona mau makahiki

Ke hoʻohana nei i kahi ʻano paura, ʻo ka hana mua e hoʻomākaukau ai i ka pohō. No ka hana ʻana i kēia, ninini i ka pauku me ka wai i loko o ka hue i nā pilikia i hiki iā ia ma luna o ke aniani. Pono e hoʻolapalapa ka wai i ka lepa. Ma hope o ke hoʻohālikelike ʻia o ke kāwili, e hui ʻia me.Hiki ke mālama ʻia ka ʻaina paʻa ʻia no ka hebedoma ma ka pahu pahu.

Ke hoʻohana ʻana i kahi pāʻina ana a me nā syringe, e ana i ka nui o ka ʻōlika. Pehea ka nui o ka manawa e pono ai e hāʻawi i ka malona i ka pēpē a hiki i ka makahiki a i ʻole ke keiki ʻōpio paha i hiki ke ʻike ʻia ma nā ʻōlelo aʻo no ka hoʻohana. Aia nā papa a e wehewehe pehea e hoʻohana ai iā lākou e helu i ka helu kūpono o ka lāʻau. I ke koho ʻana i kahi lāʻau lapaʻau, pono ke kauka e hōʻike i ka pona no kekahi hihia, me ka mālama ʻana i ka makahiki a me ka maʻi, a ʻōlelo pū ʻia i nā lā he nui e lawe ai i ka lāʻau lapaʻau maʻi.

Inā ʻaʻole nui ke keiki o ke keiki ma ka 3 mau mahina, a laila ka pā i kēlā me kēia lā he 30 mg no ka 1 kileka o ka paona kino. Lawe ʻia ka lāʻau lapaʻau i kēlā me kēia hola 12. Ma hope o 3 mau mahina, e 20 mg ka pākeke ka nui, akā hāʻawi ka lāʻau lapaʻau i kēlā me kēia 8 hola. ʻO kēia me kahi papa maʻalahi a maʻalahi paha paha o ka maʻi. I nā pilikia koʻikoʻi, hoʻonui ia i 40 mg / kg me ka manawa like.

No ka hōʻoluʻolu, ʻo ia nā mea i kahi o ke kāʻei ʻana o Amoxiclav no nā makahiki ʻē aʻe i kaʻaila.

ʻO ke keiki	ʻO ka wai, kaʻaila	ʻO ka nui o nā manaʻo i kēlā me kēia lā
3-12 mahina	1/2	3
1-7 mau makahiki	1	3
7-14 makahiki	2	3

I nā papa - no nā keiki kahiko

Hoʻonohonoho ʻia ka papa pākēlani o ke ʻano lāʻau antibacterial Amoxiclav no nā pākeke a me nā keiki ma mua o 12-14 mau makahiki. Aia i hoʻokahi papa papa 375 mg o ka pakanui ikaika. Ua lawe ʻia ʻekolu mau manawa i ka lā, hoʻokahi papa pā.

Kūlike ka ʻona i ke kūlana. Me ka panghina, hāʻawi ʻia nā keiki i kahi papa me ke anā o 8 mau hola, me kahi maʻi ʻē aʻe - i kēlā me kēia mau hola 12. I nā pilikia koʻikoʻi, hiki i ke kauka ke komo i kahi dosis hoʻokahi e hoʻokō ʻoi aku ka wikiwiki.

Pehea e hāʻawi ai i ka lāʻau lapaʻau i nā keiki o nā ʻano like ʻole?

ʻO ka pili o ka makahiki o ka mea maʻi, aia nā lula no ka lawe ʻana iā Amoxiclav:

Hōʻike ʻia me ka meaʻai. Inā inu ʻoe i ka lāʻau lapaʻau me ka meaʻai, hōʻemi nui kēia i ka hopena o ka hopena mai ka gastrointestinal tract.
ʻO ka hoʻomākaukau e kāpae ana ma mua o ka hoʻohana.
Ka nānā ʻana i ke kūlana o ka pēpē. Pono ia e mālama pono i nā hoʻololi a pau i ke kūlana a me ke ʻano o ka mea maʻi liʻiliʻi, ʻelua maikaʻi a maikaʻi ʻole. Me nā hōʻike hewa ʻole, pono ʻoe e hoʻokaʻawale i ka lāʻau lapaʻau a hele no ke kūkākūkā ʻana me kahi loea.
Mai haʻalele i ke papa. Hoʻopau ʻia ka hopena ma hope o ka pau ʻana o ke kō.
Mālama i ka lā lohi. ʻO 2 kona mau makahiki. Mālama ʻia ka hoʻopiʻi ʻana i hoʻopau ʻia i loko o ka friji no nā lā ʻaʻole 7 ma mua o 7 mau lā.
E haua i nā hana i kauoha ʻia.
ʻO ka kaohi o ke ʻano o nā pūpū, nā pēpē a me nā kaila o ka holo

Me ka maʻi maʻalahi

ʻO ka nui o ka lāʻau i ʻōlelo ʻia i loko o nā ʻano like ʻole ke hoʻoholo i ka makahiki o ka mea maʻi, akā ʻo ke kaumaha o ke kino, no ka mea, ʻokoʻa nā keiki a pau, a ʻo ka nui o ko lākou kaupaona ma ka manawa like. Eia nō naʻe, ʻo ka paʻakikī o ka papa o ka maʻi i hana like i ka hana nui i loko o ka hoʻoponopono hoʻonā.

A no ke ʻano haʻahaʻa a me ke ʻano o ka maʻi, a laila e pili ke ʻano maʻamau. Hoʻonohonoho ʻia ka hana ʻana o 125 a 250 ml paha ʻekolu mau lā i ka lā. Pono e inu i ka lāʻau antibacterial no nā lā 5-7. ʻOiaʻiʻo, aia i ke kauka e hoʻoholo i kēia. Mai kūʻokoʻa kūʻokoʻa i ka lōʻihi, keki a i ʻole ka lā maʻamau. He pōʻino a hoʻoweliweli i nā hoʻopiʻi. Inā ʻaʻole i ka hopena ka hopena me ka regimen koho i koho ʻia, a laila ʻaʻole kūpono ke antibiotic no ka hakakā ʻana i kahi maʻi kūikawā.

I nā maʻi koʻikoʻi

E pili ana i ka papa kaumaha o ke kaʻina pili, hoʻololi ka hoʻolālā. No ka mālamaʻana, ke makemake nei nā hana hoʻopiʻi me ka ʻōlelo antibacterial o 400 mg. Hoʻohana ʻia lākou e inu i ʻekolu manawa i ka lā. Ma lalo o ka mālama ʻia o ke kauka e hele nei i ka ʻohiʻōlelo. Hoʻokahi wale nō kā lākou ʻae ʻana i hiki ke hoʻoponopono ʻia. ʻO ka laʻana, hoʻonui ka nui o kēlā me kēia lā i kahi hapakolu mai ke koho maʻamau. Hiki i ke papa o ka lapaʻau ke hala ʻelua mau pule. I kēia, ʻo ke kūlana o ka mea maʻi e hana koʻikoʻi nui.

He aha nā hopena hopena a me nā hoʻopiʻi hiki?

ʻO nā lāʻau Antibacterial he mea kūpono e hāʻawi wikiwiki ai i kahi hopena wikiwiki. Aia kekahi ʻaoʻao maikaʻiʻole - kahi papa inoa o nā hoʻonā maikaʻiʻole. ʻO ka hopena maikaʻi aʻe o ka antibiotika Amoxiclav e pili pinepine i ka hana o ka gastrointestinal tract a hōʻike iā ia iho he alerio. I ka mua, ua kū ke keiki:

mea momona maikaʻi ʻole
utuka
ninini
nā ninia
nā maʻi kūhā.

ʻOi aku ka nui o ka manawa, ka lawe ʻana iā Amoxiclav i hele pū me ka ʻeha ma ka ʻōpū, colitis, hōʻeha ʻole o ka ate, hepatitis, jaundice. Eia no ka hopena maʻi kūlohelohe, hōʻike ʻia ʻo ia iho e like me:

Eia kekahi i nā hopena maikaʻi aʻe o luna aʻe, hiki i nā ʻōnaehana kino ke loaʻa i nā hopena maikaʻi ʻole: hematopoietic, lymphatic, urinary a me nā pūnaehana waena. Puka ke keiki:

thrombocytopenia
leukopenia
anemia
eosinophilia
pancytopenia
crystalluria
nephritis interstitial,
āhāhuʻe
poʻomanaʻo
pālahalahaʻai
nā wahi hiamoe hiamoe
hopohopo nui
nahoa.

Tagu inoa

ʻO ka inoa Lūkini o ka lāʻau lapaʻau ʻo Amoxiclav, Latin - Amoksiklav.

ʻO ka pāʻālua huahana i ka papa ATX (anatomical-therapeutic-chemical) i helu J01CR02.

ʻO Amoxiclav kahi hoʻohui i hoʻohui ʻia mai ka hui o nā penicillins i pale ʻia.

E hoʻokuʻu i nā palapala a me ka ʻano

Kuhi ʻia ʻo Amoxiclav 400 mg i ka pauma form, ka mea i hoʻohemo ʻia e loaʻa ai kahi kaʻa. Ke keʻokeʻo a ʻeleʻele paha ka lahilahi. ʻO ka mea hana kūlohe (amoxicillin) i kēia manawa i kahi kūlana o ka trihydrate. ʻO ka nui o ka paʻakai paʻakai beta-lactamase inhibitor ʻo 57 mg. Me ka loiloi antibacterial, ka pū ʻana o ka pauma e loaʻa i nā gum, sodium benzoate, citric acid, mannitol, nā ʻono, ka silika dioxide a me nā mea'ē aʻe. Hoʻopili ʻia ka pauka i nā hue (me ka pipette) a me nā kīʻaha pepa.

Nā hōʻailona no ka hoʻohana ʻana

ʻAmi ʻia ʻo Amoxiclav 400 no ka ʻatikala penei:

ʻO nā maʻi o nā kino ENT a me nā koikoi kiʻekiʻe (otitis media, hōʻino i nā sinuses, pharyngeal abscess, maʻi o nā tonsils, larynx a me pharynx).
Ka mumū o nā pūpū a me ke kele.
ʻO nā maʻi lēpaʻi a nā mea genitourinary o ka maʻi (urethritis, cystitis, hana i nāʻaoʻao o ka palaleka, endometritis, hōʻino i ka ʻōpū o ka ʻōpū, vulvovaginitis).
Hoʻokomo ʻia o nā iwi (osteomyelitis) a me ka kikoo hoʻohui.
ʻO ka hoʻonāukiukiʻana o ka pāhili a me nā kumu bile.
Nā puaʻa holoholona.
ʻO nā maʻi ʻeha (pyoderma).
ʻO nā maʻi Odontogenic ma kahi o ka hōʻino o ka niho.

Hoʻomaʻamaʻa ʻia ʻo Amoxiclav 400 i nā maʻi o nā kino ENT a me nā koikoi kiʻekiʻe.
Ua hoʻonā ʻia ka antibiotic i ka mālama ʻana i nā maʻi lēʻeha o nā ʻōpū genitourinary (urethritis, cystitis, hana ʻia o nā ʻōpū, endometritis, hōʻino i ka ʻōpū o ka ʻōpū, vulvovaginitis).
Hoʻomau ʻia nā pūpū o nā pūpū o ka iwi a me ka hoahana pili no ka mālama ʻana iā Amoxiclav 400.
Me ka hoʻoulu ʻana o ka gallbladder a me nā dile bile, ua kuhikuhi kēia lāʻau lāʻau.
La Amoxiclav i kauia no na bora holoholona.
Ua kuhikuhi ʻia ka lāʻau lapaʻau no nā maʻi ʻili (pyoderma).
Me ka hoʻowalewale o nā ʻōpū a me ka bronchi, ua kau ʻia kēia maʻi.

Hoʻohana nui ʻia ka lāʻau lapaʻau i ka paliko a me ka gynecology.

Pehea e lawe ai iā Amoxiclav 400

Ke koho ʻana i kahi mea lapaʻau huahana no ka komo ʻana, e noʻonoʻo pono nā ʻano makahiki o nā mea maʻi a me kā lākou kūlana.

ʻO ka dosage no nā pākeke he 25-45 mg / kg. Hiki i ka nui o ka lāʻau ke hōʻea i ka 2,085 mg. ʻO ka pahu i ka pā ana me ke ana me ka nui o 5 ml a i ʻole ka pipette i puka. ʻO ka palena loa (no ka amoxicillin) kahi 6. g. ʻO ka lāʻau lapaʻau e lawe pālua ʻia i hoʻokahi lā i ka papa.

Dosage no nā keiki

No nā keiki mai 3 mau mahina a i kahi makahiki ke kaupaona nei he 5-10 kg, ʻōlelo ʻia ka lāʻau lapaʻau ma loko o ka nui o ka ¼ a i ½ole paha pipette, e pili ana i ka nui o ka maʻi i nā manawa 2 i ka lā. No nā keiki 1-2 mau makahiki a ʻo ke kau ʻana hoʻi i ka 10-15 kg, ʻo ka pona i ʻōlelo ʻia mai ka wai e a me ¾ pipettes. ʻO nā keiki ma 2-3 mau makahiki me ka paona o 15-20 kg e kau ʻia ana mai ka ʻ¾ a hiki i ka 1 papa. 2 mau lā i kahi lā. ʻO ka mea kuhikuhi ka loiloi nui ʻaʻole ia he makahiki, akā ke kaumaha o ke keiki.

ʻO ka hōʻailona kuhikuhi ka kuhikuhi nui no ka nui o ka lāʻau, ʻaʻole ia he makahiki, akā ʻo ke kaumaha o ke keiki.

ʻŌpala Gastrointestinal

Ke lawe nei i ka lāʻau lapaʻau, nā hōʻailona o ka hōʻino i ka ʻāpana o ka digestive (hoʻomehana, ka nele i ka momona, ka wikiwiki wikiwiki, ke kīwaha i loko o ka ʻōpū, ka luaʻi). I nā hihia koʻikoʻi, aia nā:

Jaundice Loaʻa ia ma muli o ka hoʻonā ʻana o ka bile.
ʻŌpū o Hepatitis.
Colitis Pseudomembranous.
Ka hoʻonui ʻana i nā pae o ka ate enme (ALT a me AST).

ʻO kekahi o nā hopena ʻaoʻao o ka lawe ʻana i ka lāʻau lapaʻau ka nui o ka hoʻomohala ʻana o ka hepatitis.
ʻO colse Pseudomembranous kekahi o nā kumu ʻaoʻao o ka hoʻohana ʻana iā Amoxiclav.
I nā hihia koʻikoʻi, loaʻa ka hoʻonuiʻana i ka pae o ka hoʻoneʻe o nā ate.
Ke lawe nei i kahi lāʻau maʻi i nā hihia koʻikoʻi, ʻike ʻia ka jaundice.
Ke lawe nei i ka lāʻau lapaʻau, ʻo nā hōʻailona o ka hōʻino i nā mea hana o ka digestive (nausea, nele i ka momona) hiki.

Mai ka pūnaehana urinary

Hoʻokumu kekahi mau maʻi i nā nephritis (maʻi o nā keiki). ʻO ka nui o nā paʻakai e hōʻike ʻia i loko o ka mimi.

Ke hoʻohana nei iā Amoxiclav, hele mai nā hopena alakika (ʻulaʻula o ka ʻili, papula rash i ke ʻano o ka urticaria, ʻeha, angioedema, dermatitis, ʻano hoʻoluhi a me ka maʻi o Stevens-Johnson).

Ke hoʻohana nei iā Amoxiclav, kūkaʻi ka hopena o ka maʻi (ʻulaʻula o ka ʻula, nā papula papula o ke ʻano o ka urticaria, itching, etc.).

Hoʻopili pū me nā lāʻau ʻē aʻe

ʻO ka hoʻohana like ʻana o ka Amoxiclav 400 me nā antacids, chondroprotectors e pili ana i nā glucosamine, aminoglycosides, oral contraceptives, methotrexate, allopurinol, disulfiram, anticoagulants, macrolides, antibiotics mai ka hui tetracycline a me sulfonamides. Hoʻēmi i ka hoʻoneʻe ʻana o Amoxiclav Probenecid.

Hoʻonui ʻia ka hoʻonui ʻana o ka hoʻomehana ʻo amoxiclav i ke koko e:

ʻO nā mea hoʻohanaʻo Amoxiclav 400 i ka Amoxiclav Quiktab a me Augmentin (hiki ke hoʻomākaukau ʻia kahi hoʻonā inikua mai ia).

ʻO ka analogue o Amoxiclav 400 kahi Augmentin.

ʻO ka lā kau

Mālama ʻia ka pauma no 2 mau makahiki mai ka lā o kāna hoʻomākaukau. Hoʻopili ia ka hoʻopiʻi pau ʻana no kahi hebedoma inā mālama ʻia i loko o kahi friji i kahi mahana o + 2 ... + 8ºC i loko o kahi haki paʻa.

Nā loiloi a kauka e pili ana i ka lāʻau lapaʻau Amoxiclav: nā hōʻailona, ka hoʻokele, nā hopena ʻona, nā ʻōkuhi o Amoxiclav no ka hoʻohana ʻana i nā papa Amoxiclav | nā kikowaena

Amoxiclav 400 Nā manaʻo

ʻO ka loiloi o nā loea a me nā poʻe e hoʻohana i ka lāʻau lapaʻau he mea kūpono loa.

ʻO Yuri, 47 makahiki, ʻo Kostroma: “ʻO Amoxiclav e kuhikuhi pinepine ʻia i kaʻu mau mea maʻi e maʻi ana i nā maʻi maʻi o nā hui wahine. E ʻoi aku ka hopena o ka mālama ʻana i nā rula o ka mālama wahine. "

ʻO Valery, 32 makahiki, ʻo Vorkuta: "kōkua maikaʻi ʻo Amoxiclav i nā maʻi o nā kino ENT, me ka pepeiao waena. He haʻahaʻa ka lāʻau a hiki ʻole ke hāʻawi i nā hopena ʻaoʻao. "

Alena, 28 makahiki, Moscow: "ʻO ke keiki o 4 mau makahiki he 4 ua loaʻa i ka maʻi i ka maʻi bronchitis. Hana ʻia me Amoxiclav 400 i ka pauka pauka. Mea hana nui. ”

Nā palapala ʻano:

pauku no ka hoʻokuʻu ana i ka hoʻokele waha.

ʻO kēlā me 5 5 o ka paʻa ai ka 400 mg + 57 mg / 5 ml ka mea:
mea waiwai: amoxicillin (i ke ʻano o trihydrate) i ka manaʻo o ka mea hana - 400 mg, clavulanic acid (ma ke ʻano o ka paʻakai pākawa) ma nā ʻano o ka mea hana - 57 mg, nā mea hoʻowalewale: citric acid (anhydrous) - 2.694 mg, sodium citrate (anhydrous) - 8.335 mg, cellulose microcrystalline a me ka sodium carmellose - 28.1 mg, xanthan gum - 10.0 mg, colloidal silicon dioxide - 16.667 mg, silicon dioxide - 0.217 g, puaʻa cherry ʻono ʻehā - 4,000 mg, lemon lemoning - 4,000 mg, sodium saccharinate - 5,500 mg, mannitol a 1250 mg.
ʻO kēlā me 5 5 o ka paʻa o ka 250 mg + 62.5 mg / 5 ml ka mea:
mea waiwai: amoxicillin (i ke ʻano o trihydrate) i ka manaʻo o ka mea hana - 250 mg, clavulanic acid (ma ke ʻano o ka paʻakai pākawa) ma nā ʻano o ka waiwai hana - 62.5 mg, nā mea hoʻowalewale: citric acid (anhydrous) - 2.167 mg, sodium citrate (anhydrous) - 8.335 mg, sodium benzoate - 2.085 mg, microcrystalline cellulose a sodium carmellose - 28.1 mg, xanthan gum - 10.0 mg, colloidal silicon dioxide - 16.667 mg, ʻO ke silika kahakaha - 0.217 g, ke kai ʻona hihiu - 4,000 mg, sodium saccharinate - 5,500 mg, mannitol a hiki i 1250 mg.
Loaʻa kēlā me kēia 5 ml o ka paʻa i ka 125 mg + 31.25 mg / 5 ml mau:
mea waiwai: amoxicillin (i ke ʻano o trihydrate) i ka manaʻo o ka mea hana - 125 mg, clavulanic acid (ma ke ʻano o ka paʻakai pākawa) ma nā ʻano o ka waiwai hana - 31.25 mg, nā mea hoʻowalewale: citric acid (anhydrous) - 2.167 mg, sodium citrate (anhydrous) - 8.335 mg, sodium benzoate - 2.085 mg, microcrystalline cellulose a sodium carmellose - 28.1 mg, xanthan gum - 10.0 mg, colloidal silicon dioxide - 16.667 mg, ʻO ke kiko silika - 0.217 g, ka ʻōpala ʻōpala - 15,000 mg, sodium saccharinate - 5,500 mg, mannitol a hiki i ka 1250 mg.

ʻO keʻano: paulo: mai keokeo a hiki i keʻokeʻo ke ʻano.
Hoʻopau aneane keʻokeʻo a melemele i ke kala hoʻohemo homogeneous.

ʻO nā waiwai Pharmacological

Lapaʻau lāʻau
Nā hana hana i ka hana
ʻO Amoxicillin kahi antibiotic ākea ākea ākea me ka hana e kūʻē i nā microorganisms gram-maikaʻi a me ka gram-negatif. I ka manawa like, hiki i ka amoxicillin ke hōʻemi nei i ka luku, e nā beta-lactamases, a no laila ke kahe mai o ka hana o ka amoxicillin e hoʻopili i nā microorganism e hana nei i kēia enzyme.
ʻO Clavulanic acid, kahi beta-lactamase inhibitor struktally pili i penicillins, hiki i ka hana ke hana i ka nui o nā beta-lactamases i loaʻa i ka penicillin a me nā microorganism kūloko cephalosporin pale. Loaʻa i ka waikawa Clavulanic e kūpaʻa ana i ka plasmid beta-lactamases, ka mea maʻamau ke kū nei i ka pale ʻana i ka maʻi bacterial, ʻaʻole ia he hopena me ka type chromosome beta-lactamases, ka mea i pale ʻole ʻia e ka clavulanic acid.
ʻO ka heleʻana o ka acid clavulanic i ka mākaukau e mālama ana i ka amoxicillin mai ka luku ʻia e nā enzymes - beta-lactamases, kahi e hiki ai ke hoʻonui i ka lolo o ka antibacterial o amoxicillin.
ʻO ka hana aʻe ka hana o ka hui ʻana o ka amoxicillin me ka waʻa clavulanic i loko o vitro.

Nā ʻākoakoa-Gram-maikaʻi: Bacillus anthracis, Enterococcus faecalis, Listeria monocytogenes, Nocardia asteroides, Streptococcus pyogenes 1,2, Streptococcus agalactiae 1,2, other beta hemolytic steptococci 1,2, Staphylococcus aureus (methicillin-sensitive) 1, Staphylococ) coagulase-hewa staphylococci (paakiki i ka methicillin).
Nā ʻĀpilikia kūwei: Bordetella pertussis, Haemophilus influenzae 1, Helicobacter pylori, Moraxella catarrhalis 1, Neisseria gonorrhoeae, Pasteurella multocida, Vibrio cholerae.
Nā ʻili: Borrelia burgdorferi, Leptospira icterohaemorrhagiae, Treponema pallidum.
Anaerobes Gram-positive: species of genus Clostridium, Peptococcus niger, Peptostrepiococcus magnus, Peptostreptococcus micros, species of genus Peptostreptococcus.
Anaerobes mau huahana-ʻole: Bacteroides fragilis, species of genus Bacteroides, species of the genus Capnocytophaga, Eikenella corrodens, Fusobacterium nucleatum, species of the genus Fusobacterium, species of the genus Porphyromonas, species of the genus Prevotella.

ʻO nā maʻi i mea e loaʻa ai ke kūʻē i ka pale
i ka hui pū ʻana o ka amoxicillin me ka clavulanic acid

Aerobes Gram-negative: Escherichia coli1, Klebsiella oxytoca, Klebsiella pneumoniae, species of the genus Klebsiella, Proteus mirabilis, Proteus vulgaris, species of genus Proteus, species of genus Salmonella, species of the genus Shigella. Streptococcus pneumoniae 1,2, nā kāne streptococcus ʻO Viridans.
Nā ʻākoakoa-Gram-maikaʻi: ʻanoʻano o ka hanana Corynebacterium, Enterosocus faecium.

ʻOi kūlohelohe kūlohelohe
i ka hui pū ʻana o ka amoxicillin me ka clavulanic acid

Nā ʻĀpilikia kūwei: genus Acinetobacter, Citrobacter freundii, species of genus Enterobacter, Hafnia alvei, Legionella pneumophila, Morganella morganii, species of genus Providencia, species of genus Pseudomonas, species of genus Serratia, Stenotrophomonas maltophilia, Yersinia enterocolitica.
Nā ʻili: Chlamydia pneumoniae, Chlamydia psittaci, ʻano ʻōpū o ka iwi Chlamydia, Coxiella burnetii, ʻanoʻano o ka ʻano ʻano Mycoplasma.
1 no kēia mau bacteria, ua hōʻike ʻia ka hoʻomaʻamaʻa kino ʻana i kahi hui o ka amoxicillin me ka clavulanic acid.
ʻO nā 2 o nā mea maʻamau o kēia mau mea ʻaʻole i hoʻoulu i ka beta-lactamases.ʻO ka uluʻana me ka monocroʻo laxicillin e hōʻike i ka hoʻowalewale like i ka hui pū ʻana o ka amoxicillin me ka clavulanic acid.

Lapaʻau lāʻau
Kapehu
ʻO nā mea ikaika o ka lāʻau lapaʻau e wikiwiki a holo a piha ka gastrointestinal tract (GIT) ma hope o ka lawelawe waha. ʻO ka hoʻopauʻana o nā mea ikaika e kūpono loa i ka hihia o ka hoʻohana ʻana i ka lāʻau me ka meaʻai.
Ma lalo iho nei ke kūlaʻi ʻo pharmacokinetic o ka amoxicillin a me ka acid clavulanic ma hope o ke alakaʻi ʻana ma kahi maʻi 45 mg / 6.4 mg / kg, i hoʻokaʻawale ʻia i ʻelua mau minamina, e nā mea maʻi ma lalo o nā makahiki he 12.

ʻO ka kumukūʻai kūpono o nā ʻokoʻa pharmacokinetic

Сmax - kūhā i ka hoʻokaumaha plasma,

Tmax - ka manawa e hiki ai i ka plasma kiʻekiʻe,
ʻO AUC ka wahi ma lalo o ka pihi "ʻike-manawa",
T1 / 2 - hapa-ola.

Hāpai
Ma kahi o 10-25% o ka pawa mua o ka amoxicillin i hoʻopiʻi ʻia e nā keiki ma ke ʻano he metabolite ʻole ʻole (penicilloic acid). ʻO ka mole Clavulanic i loko o ke kino o ke kanaka ke hoʻomālamalama i ka hana kūlohelohe me ka hoʻokumu ʻana o 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-1H-pyrrole-3-carboxylic acid a me 1-amino-4-hydroxy-butan-2-one a hoʻāliʻi ʻia e nā ʻōpū, ma o ke kaomi ʻana, a me ka ea me ka ea ʻana, ma ke ʻano o ke kahe o nā ʻona.
Kahele
E like me ka hui pū ʻana o ka amoxicillin a me ka clavulanic acid, ka paʻa ʻana o ka therapeutic o ka amoxicillin a me ka acid clavulanic i loaʻa i nā ʻano o nā meakanu a me ka wai o interstitial (ma ke kīhole, ka palupalu o ka ʻōpū o ka ʻōpū, ka ʻili, ka adipose a me nā io o nā ʻiʻo, nā synovial a me ka peritoneal wai, ka ʻōpala, a me ka maʻi purulent) . ^ E Ha yM.
ʻO Amoxicillin a me clavulanic acid ka mea nāwaliwali ikaika i ka paʻa ʻana i nā protein plasma. Ua hōʻike nā noiʻi e pili ana i 25% o ka nui o ka nui clavulanic acid a me 18% o ka amoxicillin i loko o ke kō koko plasma e hoʻopili ai i nā protein plasma.
ʻO ka nui o nā hoʻoili e like me 0.3-0.4 L / kg no ka amoxicillin a ma kahi o 0.2 L / kg no ka clavulanic acid.
ʻAʻohe amoxicillin a me clavulanic acid e pani i ke kahe koko-lolo i ka meninges uninflamed. ʻO Amoxicillin (e like me ka hapa nui o ka penicillins) a hoʻopiʻi ʻia i ka waiū umauma.
Hiki ke loaʻa hoʻi nā ʻōhua clavulanic acid i ka umauma umauma. Me ka ʻokoʻa ʻole o ka hiki ʻana o ka naʻau, ʻohi ʻana, a me ka candidiasis o ka wahaosa waha, ʻaʻohe hopena ʻē aʻe o ka amoxicillin a me ka clavulanic acid ma ke olakino o nā pēpē hānai keiki.
Ua hōʻike nā noiʻi holoholona holoholona i ka amoxicillin a me clavulanic acid e hoʻōla i ka paepae placental. Eia naʻe, ʻaʻohe mau hopena maikaʻi loa i ka wīwī.
Leʻaleʻa
Hoʻokomo ʻia ʻo Amoxicillin e nā ʻōpū, aʻo ka clavulanic acid ma o nā hana renal a me nā mālamalama extrarenal. Ma hope o ka lawelawe waha ʻana o 875 mg / 125 mg a i 500 mg / 125 mg, ma kahi o 60-70% o amoxicillin a me 40-65% o ka clavulanic acid e hoʻololi ʻia e nā ʻoliki i ka 6 mau hola mua.
ʻO ka hapalua hapalua (ola (T1 / 2)) o ka acidxxillillin / clavulanic ma kahi o 1 mau hola; ʻo ka palena ākea ma kahi o 25 l / h i nā maʻi maʻi olakino. I ka papa o nā noiʻi like ʻole, ua loaʻa i ka ʻoi ʻana o nā amoxicillin e nā keiki i loko o 24 mau hola ma kahi o 50-85%, waikawa clavulanic - 27-60%.
ʻO ka nui o ka waikawa clavulanic i hoʻopili ʻia i ka wā 2 mau hola ma hope o ka hoʻokele ʻana.
ʻAʻole hilinaʻi ka pharmacokinetics o amoxicillin / clavulanic acid i ka male o ka mea maʻi.
ʻO ka maʻi me ka hana renal impaired
ʻO ka huina piha o ka amoxicillin / clavulanic acid e hōʻemi ana i ka hoʻokaʻawale ʻana i nā hana o ka renal. ʻOi aku ka hoʻopiʻi ʻia ʻana i nā mea hou aku no ka amoxicillin ma mua o ka clavulanic acid, no ka mea ʻO ka hapa nui o nā amoxicillin i hoʻopā ʻia e nā keiki. Pono e koho ʻia nā ʻōpala o ka lāʻau no ka hiki ʻana i ka renal i ka manaʻo pono ʻole o ka hoʻopiʻi ʻana o ka amoxicillin i ka wā e mālama ana i kahi pae maʻamau o ka clavulanic acid.
ʻO nā mea maʻi me ka hana pūlima hemahema
I nā maʻi me ka hana aho lēwa, e hoʻohana ʻia ka lāʻau lapaʻau me ka mālama. Pono e kiaʻi mau i ka hana ate.
Hoʻokuʻu ʻia nā ʻaoʻao ʻelua i ka hemodialysis a me nā liʻiliʻi liʻiliʻi e nā dialysis peritoneal.

Hoʻohana i ka wā hāpai a i ka wā o ka umauma

ʻAʻole i hōʻike ʻia nā haʻawina holoholona i nā mea pili i nā pōʻino o ka lawe ʻana i ka lāʻau lapaʻau i ka wā o ka wā hāpai a me kona hopena i ka hoʻolālā ʻana o ka wahine hānau.
ʻO kekahi noiʻi i loko o nā wahine me ka wā wehe papaha o ka membranes amniotic i loaʻa ka prophylactic therapy me ka amoxicillin / clavulanic acid i hoʻopili ʻia me ka nui o ka pilikia o ka necrotizing enterocolitis i ka poʻe hānau hou.
I ka wā hāpai a me ka lactation, hoʻohana ʻia ka lāʻau lapaʻau inā wale nō ka pōmaikaʻi i makemake ʻia i ka makuahine ma mua o ka nui o ka pilikia i ka maʻi ʻo ke keiki a me ke keiki.
ʻO Amoxicillin a me clavulanic acid i loko o nā liʻiliʻi liʻiliʻi e komo i loko o ka waiū umauma, no laila, e lawe ʻia ka lāʻau lapaʻau i ka wā o ka wā o ka hoʻoulu ʻana i ka maʻi wale nō inā e ʻike maopopo ʻia nā ʻike.
I nā pēpē e loaʻa ana i ka umauma, ka hiki ke hoʻomohala ʻana i ka naʻau, ʻeha, kandidiasis o nā membrane mucous no ka waha waha. I kēlā mau hihia, pono e hoʻokaʻawale ka pale umauma.

Loaʻa ka hopena

Wahi a ka World Health Organization (WHO), ua helu ʻia nā ʻano luhi e like me ka nui o ka hoʻomohala ʻana e like me kēia: pinepine loa (> 1/10), pinepine (> 1/100, 1/1000, 1/10000, mai nā maʻi hematopoietic a me ka lymphatic ʻōnaehana
jarang: leukopenia hōʻano hou (me ka neutropenia), thrombocytopenia,
loa loa: eosinophilia, thrombocytosis, hiki i ke agranulocytosis hiki, ke hoʻonui ʻana i ka manawa koko a me ka hoʻonui ʻana i ka manawa prothrombin manawa, anemia, e komo pū ana me ka anemia hemolytic e hoʻohuli.
Mai ka pānaʻi
loa loa: angioedema, hopena anaphylactic, vasculitis allergic, he ʻeha e like me ka maʻi serum.
Mai ka pūnaehana pili ʻana
nuliuliu: ʻeha, poʻomana,
loa loa: ʻōpū, hoʻoweliweli, hopohopo, hoʻololi i ke ʻano, hiki ke hoʻōla, hoʻāliʻi, hoʻokūkū hiki ke hele mai i nā mea maʻi me ka hana ʻana i nā mea a pau, a me ka poʻe e loaʻa nā kiʻekiʻe o ka lāʻau lapaʻau.
Mai ka gastrointestinal tract
pinepine: Kaumaha aku nō ka makemake, haʻehi, ka luaʻi ʻana, ka ʻōpū o ke ahulau.
ʻIke pinepine ʻia ke ʻano loiloi i ka wā e kau ai nā kaha kiʻekiʻe. Inā hōʻoia ʻia nā hōʻino o ka gastrointestinal tract, hiki ke hoʻopau ʻia lākou inā lawe ʻoe i ka lāʻau i ka hoʻomaka ʻana o ka pāʻina.
nuliuliu: hoʻoweliweli ka hoʻonāukiuki
loa loa: nā colitis e pili ana i ka maʻi me ka lawe ʻana i nā antibiotics (e komo pū ana i ka pseudomembranous a me ka hemorrhagic colitis), ʻeleʻele "lauoho" ʻiliʻula, gastritis, stomatitis.
I nā keiki, ʻike liʻiliʻi ka ʻili o ka papale papa o ka niho enamel. E mālama ana ka mālama waha i ka pale ʻana i ka enamel niho.
Ma ka ʻāpana o ka ʻili
nuliuliu: ʻāwili ʻili, ʻeha, urticaria,
jarang: erythema multiforme exudative,
loa loa: ʻO ke ala o Stevens-Johnson syndrome, ka necrolysis epidermal o ka mea make, dermatitis exfoliative bullous, a me ka pustulosis exanthematous ākea.
Mai ka pūnaehana urinary
loa loa: crystalluria, interstitial nephritis, hematuria.
Ma ka ʻāpana o ka ate a me ka pāpaʻi biliary
nuliuliu: hoʻonui hana o alanine aminotransferase (ALT) a me / a aspartate aminotransferase (AST), (ʻike ʻia kēia ʻano mea i loko o nā mea maʻi e loaʻa ana i ka lāʻau antibiotic beta-lactam, akā ʻike ʻia kona ʻike klinika).
ʻO nā hanana ʻino loa mai ka ate ka mea i nānā nui ʻia i nā kāne a me nā mea maʻi a hiki ke pili pū me ka lāʻau lōʻihi. ʻO nā hanana ʻino loa i nānā ʻole i nā keiki.
ʻO nā hōʻailona a me nā hōʻailona i hele pinepine ʻia ma ke a ma hope iho o ka pau ʻana o ka hoʻōla, eia naʻe i kekahi mau hihia ʻaʻole paha e ʻike ʻia no kekahi mau hebedoma ma hope o ka pau ʻana o ka lapaʻau. ʻO nā hanana ʻinoʻino ke hoʻololi pinepine ʻia.
Hiki i nā pilikia hōʻeha mai ka luhi ka maʻi paʻakikī, ma nā hihia koʻikoʻi loa i hōʻike ʻia nā hopena o nā hopena hōʻeha. I ka hapa pinepine, ʻo kēia mau mea me ka pathology concomitant koʻikoʻi a i ʻole kekahi e loaʻa i nā lāʻau hepatotoxic i ka manawa like.
loa loa: ka hoʻonui ʻana i ka phosphatase alkaline, hoʻonui i ka bilirubin, hepatitis, jaundice cholestatic (i hoʻomaopopo ʻia me ka concomitant therapy me nā penicillins a me cephalosporins).
ʻO kekahi
pinepine: nui o nā ʻili a me nā ʻili.
ʻaʻole maopopo: ka ulu ʻana o nā microorganisms insensitive.

E hoʻokuʻu i ke ʻano

ʻO ka pauka no ka pohō o ka waha
No nā dosages o ka 125 mg + 31.25 mg / 5 ml a me 250 mg + 62.5 mg / 5 ml:
ʻO ka pauku mua: 25 g o ka paukū (100 ml o ka hoʻokuʻu paʻa) i kahi kīʻahaʻeleʻeleʻeleʻele me kahi hōʻailona o ke apo (100 ml). Hoʻopili ʻia ka pahu me ka pāpale ʻili i hana ʻia o ka polyethylene density kiʻekiʻe me kahi kahe pale a me kahi hōʻailona conical i loko o ka pāpale a i ʻole ka pale keleawe ʻona me ke apo kuʻi, i loko o ke kao ka mea i hana ʻia ka polyethylene haʻahaʻa haʻahaʻa.
Pepa lua:
Hoʻokahi pahu me kahi puna wai me nā hōʻailona annular i loko o ka lua o 2,5 ml a me 5 ml ("2,5 SS" a me "5 SS"), ka hōʻailona kiko piha o 6 ml ("6 SS") ma ka paʻa o ke puna a me nā kauoha no ka hoʻohana lāʻau i loko o kahi pahu pepa.
ʻO kahi pahu me kahi pipette dosage puka palena a aʻo nā kauoha no ka hoʻohana ʻana i ka lāʻau lapaʻau i kahi pahu pahu.
No kahi pā ana o 400 mg + 57 mg / 5 ml:
Ke kīpopole mua: 8.75 g (35 ml o ka hoʻōki paʻa), 12.50 g (50 ml o ka ʻauʻa ʻana i hoʻopau ʻia ai), 17,50 g (70 ml o ka hana hoʻokele paʻa) a i ʻole 35.0 g (140 ml o ka hoʻōki paʻa) o ka pauka i loko o kahi ʻeke wai aniani me kahi kaʻe ʻāpana i hana ʻia me ka polyethylene density kiʻekiʻe me kahi kāʻei hoʻokele a me kahi hōʻailona i paʻi ʻia i loko o ka pāpale.
17,50 g (70 ml o ka hoʻokō ʻana i hoʻopau ʻia) i loko o kahi pahu aniani i kahi aniani me kahi hōʻailona mama (70 ml) me kahi pāpū kikoo i hana ʻia o ka polyethylene density kiʻekiʻe me kahi apo hoʻomalu a me kahi hōʻailona kuhi i loko o ka pāpale.
Pepa lua:
ʻO kahi pahu me kahi pipette dosage puka palena a aʻo nā kauoha no ka hoʻohana ʻana i ka lāʻau lapaʻau i kahi pahu pahu.