9 a me nā mea haʻahaʻa kūpono i nā Rosuvastatin

Hōʻike ʻia nā hōʻike o ka lāʻau Krestor, e like me ka pauku i ke olakino, i kapa ʻia "synonyms" - nā mea hoʻohuli i hoʻololi ʻia i loaʻa i nā mea hou a i ʻole ke ʻano o ka hopena o ka hopena i ke kino. Ke koho ʻana i nā unuhi, e noʻonoʻo wale ʻaʻole i kā lākou kumukūʻai, akā no ke aupuni o ka hana a me ka maikaʻi hoʻi o ka mea hana.

ʻO ka wehewehe ʻana i ka lāʻau lapaʻau

ʻO Rosuvastatin kahi mea koho paʻa, hoʻokūkū hoʻokūkū o ka HMG-CoA reductase, he enzyme e hoʻololi i ka 3-hydroxy-3-methylglutaryl coenzyme A i ka mevalonic acid, kahi mua kolesterol. ʻO ka pahuhopu nui o ka hana a rosuvastatin ka ate, kahi i lawe ʻia ai ka synthesis o ka cholesterol (kolesterol) a me ka catabolism o nā lipoproteins low density (LDL).

Hoʻonui ka Rosuvastatin i ka nui o nā mea hoʻokipa LDL "hepatic" ma luna o ka pūlaka, e hoʻonui ana i ka hiʻona a me ka catabolism o LDL, a me ka huli ʻana i ka pale ʻana o ke kāpae ʻana o ka lipoproteins haʻahaʻa haʻahaʻa (VLDL), a laila e hōʻemi ana i ka nui o ka nui o ka LDL a me VLDL.

Ua hoʻohaʻahaʻa ka krestor ® i ka hoʻokiʻekiʻe ʻana o ka LDL cholesterol (cholesterol-LDL), ka nui o ka kolamu, triglycerides (TG), e hoʻonui i ka pae o ka lipoprotein cholesterol kiʻekiʻe (HDL-C), a me ka hoʻohaʻahaʻa hoʻi i ka ʻike o ka apolipoprotein B (ApoV), non-HDL cholesterol, -LVONP, TG-VLDLP a hoʻonui i ka kealike o ka apolipoprotein AI (ApoA-I) (e ʻike i nā papaʻaina 1 a me 2), e hōʻemi ana i ka pae o LDL-C / HDL-HDL, ka nui kolesterol / HDL-C a me HDL-C / HDL-C a me Mahele ApoB / ApoA-1.

Hoʻokomo ka hopena therapeutic i loko o hoʻokahi pule ma hope o ka hoʻomaka ʻana o ka hopena me Krestor ®, ma hope o ka 2 mau pule o ka lapaʻau i hōʻea ʻo 90% o ka hopena hiki loa. Loaʻa ka hopena olakino kiʻekiʻe loa e ka hopena o ka wiki 4 ma ka mālama ʻia a mālama ʻia me ka hoʻohana maʻamau ʻana i ka lāʻau.

Papa a 1 a me 1a.Ka hopena ʻana i ka dosage ma nā maʻi me ka hypercholesterolemia mua (type IIa a me IIb e like me Fredrickson) (kela loli hoʻololi hoʻololi ka hoʻohālikelike ʻia me ka waiwai mua).

He mea kūpono ia ʻo Krestor ® i ka poʻe maʻi maʻi me ka hypercholesterolemia me ke ʻano ʻole o ka hypertriglyceridemia, me ka manaʻo ʻole o ka lāhui, ka wahine a i ʻole ka makahiki, incl. i nā mea maʻi me ka maʻi mellitus a me hypercholesterolemia familial.

I ka 80% o nā mea maʻi me ka type IIa a me IIb hypercholesterolemia e like me Fredrickson (ʻo ka ʻōpū maʻamau o ka LDL kolamu ma kahi o 4.8 mmol / L) aʻo ka lawe ʻana i ka lāʻau lapaʻau ma kahi o 10 mg, ua hōʻemi ka ʻike o ka LDL cholesterol i nā waiwai ma lalo o 3 mmol / L.

I ka poʻe maʻi me ka hypertriglyceridemia me ka maka o ka mua o TG mai 273 a 817 mg / dl i loaʻa iā Krestor ® ma loko o kahi pākaʻi o 5 mg a 40 mg hoʻokahi manawa i ka lā he 6 mau pule, ua hoʻemi nui ʻia ka manaʻo o TG ma ka lolo koko (me ka papa ʻaina 2).

Hoʻomaopopo ka hopena hoʻohui me ka fenofibrate i ka pilina o ka triglycerides a me ka hoʻōla nikotinic ma nā lipid e hoʻohaʻahaʻa i nā papa pili i ka pili o HDL-C.

Ma ka noiʻi METEOR, e pili ana i nā mea maʻi 984 o ka makahiki 45-70 mau makahiki me ka haʻahaʻa haʻahaʻa o ka hoʻomohala ʻana i ka maʻi naʻau coronary (10 makahiki i ka hopena o ka Framingham haʻahaʻa ma mua o 10%), ka awelika o ka LDL kolamu o 4.0 mmol / l (154.5 mg / dl) a me ka atherosclerosis subclinical ( i loiloi ʻia e ka mānoanoa o ka intima-media complex o nā carotid arteri - TCIM) ua aʻo mākou i ka hopena o rosuvastatin i ka mānoanoa o ka paʻakikī intima-media. Loaʻa nā mea maʻi i ka rosuvastatin ma kahi pānaʻi o 40 mg / lā a i ʻole placebo no 2 mau makahiki.Ua lohi nui ka lāʻau Rosuvastatin i ka holomua o ka holomua o TCIM no 12 mau ʻāpana o ka ʻenekene carotid i hoʻohālikelike ʻia me placebo me kahi ʻano like -0.0145 mm / makahiki. Hoʻohālikelike ʻia me nā waiwai mua o ka hui rosuvastatin, kahi hōʻemi i ka nui o ka waiwai nui o ka TCIM e 0.0014 mm / makahiki (0.12% / makahiki (ʻokoʻa ka maikaʻi ʻole)) i ʻike ʻia me ka hoʻonui ʻana o kēia hōʻailona ma ka 0,0131 mm / makahiki (1.12% / makahiki (p 1/100 , 1/1000, 1/10000, Nā ʻatikala e pili ana

I ka nui o nā hihia, e hōʻeha ʻia nā maʻi i ke kanaka inā ʻaʻole ʻo ia e mākaukau me kā lākou. ʻO nā maʻi Viral ka maʻi maʻamau i loko o ka honua o kēia ao. Me lākou, hele pinepine ʻia nā maʻi e pili ana i ka ʻoihana ʻōnaehana. I.

Mālama i nā kānaka kūlohelohe i ke kanaka i ke kakahiaka o ka manawa. ʻAʻole i nalowale nā ​​hoʻomaʻamaʻa kūlohelohe no ka poʻe hou i ko lākou pili. ʻOkoʻa ka hopena ʻana i ka colitis ulcerative me ka hoʻoponopono ʻana o ka lāhui i kahi ala komo. Pākuʻi.

Hiki i kekahi ihu waiʻa i loko o nā pōpoki ke kumu no nā ʻano kumu. ʻO ka pinepine loa, ʻike ʻia ka puka ʻana o ka ihu i kekahi holoholona ma muli o ke anuanu maʻamau. I kekahi manawa he hopena o ka rhinitis he hopena o nā alerine a i ʻole kekahi mauʻano maʻi koʻikoʻi.

Nā ʻāpana ʻōpala

ʻO ka mea ikaika o ka lāʻau lapaʻau ka paʻakai kaleka o rosuvastatin. Eia kekahi, ʻo ka ʻōnaehana hoʻonohonoho ʻana i kekahi o nā mea hoʻohui, ʻo kēlā me kēia mea i ka hana:

1. ʻO cellulose Microcrystalline kahi mea maikaʻi loa e hoʻopili ʻia ana mai ke kino kanaka. I ka hoʻohuiʻana o nā lāʻau lapaʻau, hana ia i mea hoʻopiha a me kahi mea e lawelawe ai e hoʻopili i nā mea āpau.
2. Lawaʻawa Lactose. Hoʻohana e hoʻomaikaʻi i ka ʻono o ka lāʻau lapaʻau. Eia naʻe, hiki i kēia mea ʻenehana ke lawe i nā papa no nā poʻe e ʻeha nei me ka nānā ʻole i ka lactase.
3. Kalikoli Kalepa ʻO kēia kahi hui paʻakikī, kahi i loaʻa ka metallic calcium a me ka phosphoric acid. ʻO ke hoʻonohonoho ʻana o nā papa e kōkua i ka assimilation o ka hana koʻikoʻi koʻikoʻi.
4. ʻO ka lāʻau ʻo Magnesium. Mālama i ka papa hana papa ʻaina a lawelawe ia e like me kahi hoʻopiha piha no ka kino.
5. ʻO ka Hydroxypropyl methylcellulose kahi hoʻohui hoʻohui moisturizing kūikawā e pono no ke kaʻina hana o ka palapala hana.
6. ʻO Povidone e hana i ka ʻōpū e hoʻokaʻawale i nā mea ʻona i ka kino, me nā mea i kū ʻia ma ka hopena o ka hana a rosuvastatin.
7. ʻO Triacetin kahi kākoʻo meaʻai ʻāpono (E1518). Ma kahi ʻāpana o nā papa, he hana ia me ka plasticizer a me kahi moisturizer, kahi nui no ka kaʻina.
8. Pahu - ka mea hao hao a me ka titanium dioxide he mau mea hoʻohui palekana e hoʻomaikaʻi i ke ʻano o ka lāʻau lapaʻau.

ʻO nā papa Rosuvatatin, i hoʻohana ʻia no ka cholesterol ma luna o ka palaki, ua hua ʻia e nā hui lāʻau lapaʻau ma lalo o nā inoa like ʻole. ʻO nā āpau āpau he kikoʻī pololei, ʻo ia hoʻi, he ʻano like ko lākou mau ʻano.

ʻO ka lāʻau lapaʻau mua Krestor e hana ʻia mai e kahi ʻoihana Pelekane a loaʻa iā ia ka maikaʻi e like me ka lāʻau lapaʻau kiʻekiʻe maikaʻi loa. ʻO nā lāʻau āpau āpau kahi o ka pakanui ʻano mea rosuvastatin he generics.

ʻOkoʻa lākou i ka mea mua ma ke kumukūʻai a loaʻa paha kahi mea hoʻonaninani like ʻole o nā mea kōkua, ʻaʻole i ʻike nui i ko lākou hopena. Pono e noʻonoʻo i kēia wahi me ka hoʻonui nui ʻana i kekahi mau mea.

Ka hana lāʻau lapaʻau

ʻO ka lāʻau hypolipidemic he mea koho, hoʻokūkū paʻa o ka HMG-CoA reductase, he enzyme e hoʻololi i ka 3-hydroxy-3-methylglutaryl coenzyme A i mevalonate, kahi mea mua o ke kolamu (Xc). ʻO ka pahuhopu nui o ka hana o ka rosuvastatin ka mōʻī, kahi i lawe ai ke ʻano Xc synthesis a me LDL catabolism.

Hōʻike ka hopena therapeutic i loko o ka 1 mau pule ma hope o ka hoʻomaka ʻana o ka hoʻomaʻamaʻa ʻana o Krestor, ma hope o ka 2 mau pule o ka lapaʻau i hōʻea 90% o ka hopena hiki loa. ʻO ka hopena therapeutic kiʻekiʻe e loaʻa pinepine i ka 4 wiki a mālama ʻia me ka hoʻohana maʻamau.

Ma kahi o 90% o ka loaʻaʻana o ka rosuvastatin i hoʻopuka ʻia i hoʻololi ʻole ʻia me nā feces. Hoʻokuʻu ʻia ke koena i loko o ka mōʻai.

Nā hiʻohiʻona o ka lāʻau

ʻOi aku nā huahana ma mua o ka mea mua, a hiki i ke mea maʻi ke kūʻokoʻa kūʻokoʻa i kahi lāʻau lapaʻau me kekahi, e pili ana i ka loaʻa a loaʻa paha i ka lāʻau lapaʻau i ka lāʻau lapaʻau. ʻOkoʻa ka like i ka maikaʻi, ka mea i pili me ka maikaʻi o nā mea i hoʻohana ʻia a me kekahi mau ʻokoʻa i ka hana. Kahiana ʻano ma ka waiwai o ke ʻano he rosuvastatin:

1. ʻOkaʻohana. ʻO ka lāʻau maoli i hana ʻia ma ka UK. Loaʻa iā ia nā bioavailability kiʻekiʻe, kahi hopena therapeutic wikiwiki me ka cholesterol ma mua o ka maʻamau. He kumukūʻai kiʻekiʻe kona i hoʻohālikelike ʻia me nā loea.
2. Hoʻokomo ʻo Akorta, Rosuvastatin Canon a me Rosuvastatin SZ i ka hana ʻo Lūkia. Aia lākou i ka māhele o nā moʻo loea māmā. Akā iā lākou bioavailability haʻahaʻa haʻahaʻa, ʻoi aku ka hoʻomohū hou i ka noʻonoʻo ʻana i loko o ke kino e pono ai e hoʻokō i ka hopena kiʻekiʻe. Hoʻopili koke ʻia ia ma ke kino.
3. Mertenil. Mea hana - Hungary. He haʻahaʻa haʻahaʻa nō ia o ka bioavailability, no laila ka hopena therapeutic ma hope ma mua o ka lāʻau lapaʻau mua.
4. ʻO Rosulip kekahi lāʻau lapaʻau hou mai nā mea hana Hungarian. ʻAʻole ia ke kumukūʻai kiʻekiʻe. Hoʻohālikelike ʻia e ka bioavailability kiʻekiʻe, akā i ka manawa like, me ka lohi iki, hōʻuluʻulu ʻia, kālai i ka ʻola hoʻokaumaha makemake.
5. Ua hoouka ʻia ʻo Rosart e kahi hui ʻo Iceland. Loaʻa iā ia nā pono āpau o ka lāʻau mua, nā hemahema e pili ana i kona kumukūʻai kiʻekiʻe.
6. Rosistark. ʻO ke kūkulu ʻana mai Kroasia. ʻAʻole he haʻahaʻa i ka Rosart a i ʻole Krestor ma kekahi ʻano, i ka manawa nui a ua loaʻa ke kumu kūʻai nui.
7. Kauoha Hoʻohana ia e kahi lāʻau lapaʻau i ka Israel, hoʻopili koke i loko o ke kino a loaʻa kahi hopena therapeutic. He kumukūʻai kiʻekiʻe.
8. Hana ʻia ʻo Roxer e kahi ʻoihana kikowaena kaulana o Slovenia. He kumukūʻai pālua, maikaʻi bioavailability, akā wikiwiki ka excreted mai ke kino a no laila ke ahonui ka hopena.
9. ʻO Rosucard kahi mākaukau Czech. I kekahi kumukūʻai, he nui bioavailability kiʻekiʻe, akā he haʻahaʻa haʻahaʻa o ka hoʻomaka ʻana i ka hana therapeutic.

ʻO kēia mau lāʻau āpau he mau kuʻuna kūpono, i.e., me ka mea hana ikaika a like no ka like like. Ma ka hoʻomaʻamaʻa, hoʻokahi lākou a me ka mea like pono, kahi i loaʻa nā inoa waiwai ʻokoʻa a kūʻai ʻia i nā kumukūʻai like ʻole. Aia nā kūlaki kūloko.

ʻO kēia mau lāʻau lapaʻau he hopena hoʻokahi (ma kēia hihia, lipid-lowing), akā heʻokoʻa nā mea ʻokoʻa. Hiki ke hoʻopili ʻia e nā kauka like me nā kauka.

ʻO ka pharmacokinetics i nā hihia lapaʻau kūikawā

ʻAʻole pili ka pōpilikia a me ka makahiki i ka hopena koʻikoʻi o nā maʻi i ka pharmacokinetics o rosuvastatin.

I nā maʻi me ka hōʻemiʻole a hoʻololi ʻole i ka renal ka hopena, ʻaʻole nui ka hoʻololi o ka plasma o ka rosuvastatin a i ʻole N-dysmethyl.

I nā maʻi me nā pilikia hana ʻole maikaʻi (CC 1/100, 1/1000, 1/10 000,

9 a me nā mea haʻahaʻa kūpono i nā Rosuvastatin

• Nā ʻāpana ʻōpala
• Nā hiʻohiʻona o ka lāʻau

Ua hoʻākāka ʻia ka Rosuvastatin a me nā mea hoʻohui i nā kolamu ma ke koko ma mua o ka maʻamau. Aia ka lāʻau lapaʻau i nā papa o nā statins o nā mau heʻehā (4 mau hanauna). Hoʻohālikelike ʻia me nā lāʻau lapaʻau ʻē aʻe i kēia hui, ʻo rosuvastatin kahi hana ʻoi aku ka palekana a palekana.

Ua hana ʻia synthetically a hōʻike i nā waiwai hydrophilic, ma muli o ke kī ʻole i ka hopena ʻino i ka pʻā.

Hoʻololi maikaʻi nā lāʻau i ka hana ʻana o nā lipoproteins haʻahaʻa haʻahaʻa, ʻo ia ka mea nui i hana ʻia ai ka cholesterol.

Eia kekahi, ʻo ka lawe ʻana i kēia lāʻau lapaʻau ʻaʻole ia e hoʻonā i nā pulupulu o nā palahalaha a me nā mea āpau ʻē aʻe mai ka ʻaoʻao o ka pono o ka ʻiʻo. Hōʻike ʻia ka hopena kūpono i hoʻokahi hebedoma ma hope o ka hoʻomaka ʻana o ka hoʻohana ʻana, a ma ka 4 heʻe lilo i lilo loa ia a me ka mālama maʻamau ka lōʻihi. ʻO kēia mau hiʻohiʻona e hana ai i ka rosuvastatin he lāʻau noiʻi nui no ka poʻe maʻi e pono ai e hoʻohaʻahaʻa i ka kolamu.

Crestor: nā ʻōlelo no ka hoʻohana ʻana, nā analogues, nā kumukūʻai a me nā loiloi

1. Hoʻomili hou a me ke ʻano hoʻohālikelike
2. Hiki i nā pono Pharmacological
3. Lapaʻau lāʻau
4. Lapaʻau lāʻau
5. ʻO wai i hōʻike ʻia ʻo Crestor
6. Pehea e hoʻopili ai
7. Nā hopena hopena
8. Wāwī palapala noi
9. Ka kuʻikahi me nā lāʻau lapaʻau ʻē aʻe
10. Kahiwa: nā kikowaena
11. He aha nā mea a nā kauka a me nā mea maʻi e noʻonoʻo ai no Crestor

Ua hoʻohana maikaʻi kā mākou poʻe heluhelu iā Aterol e hoʻohaʻahaʻa i ka cholesterol. Ke ʻike nei i ka kaulana o kēia huahana, ua hoʻoholo mākou e hāʻawi iā i kou makemake.

Hiki iā ʻoe ke lilo i ka palaka o ke ola maʻamau, a ma hope o ke ʻano loiloi, e aʻo e pili ana i ka hyperlipidemia - he nui ka nui o ka kolamu a me nā triglycerides i ke koko. Hoʻonui koʻikoʻi ka maʻi Asymptomatic i ka hopena o ka plaher atherosclerotic - nā mea ākea o ka puʻuwai naʻau a me nā hōʻeha.

ʻO Krestor, kahi lāʻau lapaʻau hope loa i hoʻolālā ʻia e hoʻoponopono hou i nā metabolid lipid, e kōkua i ka pale aku i nā hopena pōʻino.

Hoʻomili hou a me ke ʻano hoʻohālikelike

Kuhi ʻia ke kea ma ke ʻano o nā papa. Wahi a ka hoihoiʻana i ka mea kanu ikaika, ua nui nā ʻano o nā lāʻau lapaʻau:

1. ʻO nā mea i hōʻailona ʻia i ka melemele a ua kahakaha ʻia me ZD4522 5 he konvex, he puni, he 5 g o ka rosuvastatin.
2. ʻO nā peni maʻa Crestor o kahi ʻano like like i kahakaha ʻia me ZD4522 10 he 10 mg o ka waiwai ikaika.
3. Ma ke ʻano like o nā papa me ka palapala palapala ZD4522 20 - rosuvastatin 20g.
4. ʻO ka pae kiʻekiʻe loa o ka waiwai ikaika (49 mg) i loko o nā papa ʻulaʻula me ka hōʻailona o ka ZD4522.

ʻO nā ʻano lāʻau āpau (me ka helu o nā analogues) i kūlike loa

Lapaʻau lāʻau

Hoʻopiliʻo Krestor i ka hoʻoneʻe ʻana o HMG-CoA, kahi enzyme e mālama i ka hana o mevalonate, kahi mua kolesterol. E hana ana ʻo Rosuvastatin i ka puʻu - kekahi o nā papa nui.

Ua hōʻemi ʻo Statin i ka nui o nā lipoproteins me ka haʻahaʻa haʻahaʻa a me ka haʻahaʻa e ke kāohi ʻana i ko lākou synthesis, me ka ulu ʻana o ka HDL i ka hoʻohui a me ka catabolism LDL. ʻO ka hopena, ua hoʻemi ka nui o ka kolamu o ka kolamu, LDL a me ka triglycerides. Ma ka manawa like, hoʻonui ka hoʻoili o HDL.

Hoʻohana ʻia ka Rosuvastatin no ka hypercholesterolemia i ka hui pū ʻana me ka ʻole hypertriglyceridemia, no nā mea maʻi o kekahi ʻano kāne, ʻano a me ka lāhui.

ʻO ka hopena o ka hoʻohana ʻana o Krestor, ka hoʻopaʻi ʻia e ka pane mai nā poʻe noiʻi, ʻike ʻia e ka hopena o ka pule mua o ka papa, akā ʻike ʻia ka hopena kiʻekiʻe (ma o 90%) ma hope o he mau hebedoma 2-4 o ka hoʻohana maʻamau.

ʻAʻole i like kekahi o nā mea kikoʻī, ʻo Krestor kahi liʻiliʻi o nā hopena maikaʻiʻole o ka ate. Hoʻohana ia ia me ka hui pū me ka lāʻau haʻahaʻa haʻahaʻa a me nā lāʻau ʻē aʻe e hoʻohaʻahaʻa i ka cholesterol.

ʻO wai i hōʻike ʻia ʻo Crestor

Ke hoʻololi nei iā Krestor me nā analogues, pono ia e wehewehe i lalo o nā kūlana i hoʻohana ʻia ai.

Hōʻike ʻia ka lāʻau kūlohelohe mua:

• Me ka hypercholesterolemia (i ka ʻano homozygous a i ʻole ka familial).
• No ka pale ana i ka walo,
• Me ka hypercholesterolemia i hui ʻia,
• No ka pale ʻana i ka puʻuwai naʻau,
• ʻO nā poʻe me ka atherosclerosis,
• Me ka hypertriglyceridemia.

Pehea e hoʻopili ai

Hana ʻia ka lāʻau lapaʻau me ka dosage e ke kauka i hoʻokumu ʻia ai, nā kūlana o ke olakino, nā maʻi concomitant.

Hoʻolaha pili no ka hoʻohana ʻana o Crestor:

• ʻAʻole pono ke papa ʻaina.
• ʻO ka manawa manawa - hiki ke loaʻa kahi hopena kūpono loa mai ka hoʻohana ʻana i ke ahiahi, ʻo ka mea nui ka hānai o ka cholesterol i ka pō.
• ʻAʻole ʻai ka ʻai i ka hopena o ka lāʻau lapaʻau.
• Ma mua o ka hoʻomaka ʻana o ke papa, pono e loli ka mea maʻi i kahi ʻai haʻahaʻa haʻahaʻa, kahi e mālama mau ai ia.
• Koho ʻia ka maʻi mua o Crestor (5-10g / lā). Inā ʻaʻole i loaʻa nā hopena i nā manaʻolana, hiki iā ʻoe ke hoʻoponopono i ka maʻa i ka 20 mg / lā, akā ʻaʻole ma mua o hoʻokahi mahina ma hope aku. ʻO ke ʻano kiʻekiʻe (40 mg / lā) i kuhikuhi wale ia i ka hopena kiʻekiʻe loa e hoʻomohala ai i nā maʻi vascular a me nā maʻi puʻuwai. Pono ka mea maʻi me ka hypercholesterolemia koʻikoʻi ma lalo o ka mālama mālama olakino maʻamau, me ka hoʻonui ʻia ʻana o ka hopena ʻaoʻao. Pono ka nānā ʻana i nā ʻikepili lipid kiʻi e hoʻoponopono i ka papa o ka lapaʻau e pono e lawe ʻia aku i kēlā me kēia he 2 mau pule.

I kahi hihia o ka overdose, ʻaʻole i hoʻohana ʻia kahi antidote kūikawā. Hoʻomaʻamaʻa ka hoʻomaʻamaʻa, me ka mālama ʻana i ke kiʻekiʻe o ka lāʻau ʻona. Inā pono, e lawe i nā hana kākoʻo.

Nā hopena hopena

Me ka mālama pono ʻana i nā ʻōlelo aʻo i kau ʻia e ke kauka, hiki i nā mea maʻi ke hoʻopiʻi pinepine nei i nā hopena kumu ʻole mai ka hoʻohana ʻana o Krestor. Eia naʻe, ua hōʻike aku i nā ʻōlelo aʻo no ka hoʻohana ʻana i ka hopena o nā hopena i makemake ʻole ʻia. Hoʻokumu ʻia ka ʻikepili ma nā noiʻi loea.

ʻO nā lāʻau āpau o luna o ka lālani nā mea hoʻohālike e pili ana i ka rosuvastatin, ʻo ia hoʻi nā lāʻau me nā mea ikaika like. I ka ʻoiaʻiʻo, hana āpau - like ia ka lāʻau like me nā inoa kūʻokoʻa like ʻole a kūʻai ʻia ma nā wahi kūʻai a me nā kumukūʻai kūʻai like ʻole (e hāʻawi ʻia ke kumukūʻai kūʻai awelika ma ka papa i ka ʻaoʻao e hiki mai ana o ka hoʻolaha). Aia kekahi hui kūlohelohe kūʻokoʻa, ʻo ia hoʻi, nā lāʻau lapaʻau mai kekahi hui lāʻau lapaʻau (ma kēia hihia, reductase inhibitors), kahi like ka hopena, akā mau ʻokoʻa like. ʻO kēia mau lāʻau i nā huaʻōlelo kūlohelohe a hiki ke kuhikuhi wale ʻia e ka poʻe e hele nei i ka loiloi ma ka kumu o ka ʻike makana.

ʻO ka papa hoʻohālikelike o ke kumukūʻai o nā kikowaena o "Rosuvastatin"

No ka like o ke aʻo ʻana, i hana wale ʻia ma ka manaʻo o nā mea hoʻohana o nā lāʻau lapaʻau e nīnau ʻia nei, aia ka papa inoa ma luna nei i nā analogues i loko o kēia kaha a me nā helu: 10 mg o rosuvastatin i kēlā me kēia papa, 30 papa i hoʻokahi pā. ʻO kēia ʻano hoʻokala he mea kaulana loa i waena o nā mea kūʻai, no ka mea, e aʻo ʻia e hoʻomaka i ka lawelawe ʻana i ka lāʻau i loko o kēlā me kēia mahina e hiki ai ke hoʻoholo i ke kiʻekiʻe o ka hoʻohālikelike ʻana i ke kino o ke kanaka iā rosuvastatin.

ʻO ke kumu kūʻai o "Rosuvastatin" a me ka hiki ke hoʻololi me ia

I loko o ke kumukūʻai kūʻai olakino "Rosuvastatin" ma kahi o 10 mg a me ka helu o nā papa, 30 mau ʻāpana he kūʻai i loko o nā kumu kumukūʻai mai 380 a 490 mau rubles, e pili ana i ke kumu kūʻai kumu kūʻai a me ka mea kūʻai aku o nā huahana lāʻau, a me ka mea e pili ana i ka ʻāina. No laila, i ka hapanui o nā hihia, ʻoi aku ka mea kūʻai mua loa ma ka Rosuvastatin ma mua o kona mau kikowaena, a ua pono ke kūʻai aku i ka analogue wale nō inā ʻaʻole i loaʻa ka lāʻau lapaʻau maoli ma kēia kīkeke. Ma muli o nā loiloi i hoʻopili ʻia ma ka ʻatikala o ka lehulehu ma ka Pūnaewele a ma ka paʻi nūpepa, hiki ke hoʻoholo ʻia no ka makemake o ka poʻe kūʻai aku i ka lāʻau mua.

ʻO nā loina o ka lāʻau lapaʻau

ʻO ka pharmacodynamics o Krestor ka mea e hoʻopuka i kahi enzyme kūikawā e kāohi ana i ka hana ʻana o kahi cholesterol precursor a mevalvalate.

ʻO ka hana ikaika o ka lāʻau lapaʻau e hana pololei i ka palupalu, e hana ana i ka cholesterol.Ke kōkua nei kēia enzyme i ka hoʻohaʻahaʻa ʻana i ka lipoproteins low low, e kōkua ana i ka hōʻemi o ka nui o ka cholesterol i loko o ke kino, a me ka triglycerides.

Eia kekahi, hāpai nā kiʻekiʻe o ka kolu kiʻekiʻe. Hoʻohana ka lāʻau lapaʻau no nā mea maʻi o kekahi makahiki, ʻano wahine a me nā lāhui. He nui nā loiloi o nā mea hoʻohana ʻana i ʻike ʻia ka hopena o ke hoʻohana ʻana iā Krestor i ka hebedoma mua o ke papa, ʻoiai ʻo ka hoʻokō koʻikoʻi ma hope ma hope o ka hoʻopau ʻana i ke papa ma nā hebedoma ʻo 2-4 ka hoʻohana mau.

ʻO ke ke kea, ʻaʻole like me kona mau analog kekahi, loaʻa i ka hopena maikaʻi loa e pili ana i ka pakanā o ke kanaka. ʻOi aku ka maikaʻi i ka hoʻohui pū ʻana o kona hoʻohana me kahi meaʻai kūikawā, a me kekahi mau lāʻau ʻē aʻe e pili ana i ka hoʻohaʻahaʻa i ka cholesterol.

ʻO ka hua ʻolaka hakahaka o ka lāʻau lapaʻau ka mea penei:

1. I ka pae o ke kīnā. Hōʻike ka nui o ka statin i ke koko ma hope o 5 mau hola, ma hope o ka hoʻohana ʻana i ka lāʻau.
2. I ka hoʻoili ʻia i loko o ke kino. ʻO ka hana nui a Krestor ʻo ia ka pepeka, kahi e hoʻoili ai i ka kolamu. ʻO ka laha hoʻoili he 134 lita.
3. I ka mākeke o ka waihona hana nui. No Krestor, aia ma kahi o 10%.
4. I ke ʻano kumupaʻa. ʻO ka nui o nā lāʻau lapaʻau e ʻoki ʻia mai ke kino ma kahi o 90% i loko o nā hola 19 o ka hoʻokele.

ʻO nā makahiki o ka mea maʻi, ʻo ia hoʻi me ka wahine, ʻaʻohe hopena o ka hopena o ka pharmacokinetic o ka lāʻau.

Pono e mālama pono i ka hele ʻana o ka maʻi o ka maʻi. Pēlā, ʻaʻole i hoʻopōʻino i ka pae o ka renal ka hopena i ka pae o ka statin, ʻoiai i ka hana koʻikoʻi, ʻoi aku ka piʻi ʻana o ka rosuvastatin 3 mau manawa.

ʻAʻole ka hopena o ka hōʻili ʻana i nā ʻōpū o ke au i ka hoʻohana ʻana i ka lāʻau.

Krestor - nā analogues o ka lāʻau a me nā hōʻike no ka hoʻohana

ʻO kahi analogue haʻahaʻa a i ʻole ke kahakaha no ka lāʻau lapaʻau, inā hoʻoholo ka mea maʻi e hoʻohana i ia, pono kahi ʻano akahele.

I nā huaʻōlelo ʻē aʻe, nā mea maʻi e hoʻoholo ai e hoʻololi i ka lāʻau lapaʻau mua me ka laiki lapaʻau e pono e kamaʻilio pū i kā lākou kauka, a i ʻole familiarize iā lākou iho me nā mea e ʻike ʻia no ka hoʻohana ʻana i kā lākou ʻōlelo.

I ka mua, ʻōlelo ʻo Krestor e hoʻohana ana:

• me ka hypercholesterolemia,
• me ke pale ʻana i ka ʻeha a me ka puʻe ʻana i ka naʻau,
• me ka hypercholesterolemia,
• poʻe me ka atherosclerosis,

Eia kekahi, pono e hoʻohana i ka lāʻau lapaʻau i ke alo o hypertriglyceridemia.

Nā ʻōkuhi no ka hoʻohana ʻana i ka lāʻau lapaʻau

ʻO Krestor, e like me nā lāʻauʻokoʻa'ē aʻe, aia kāna hana ponoʻī a me ka nui o ka hoʻohana ʻana.

Ma ke ʻano he kānāwai, ʻo ia ke kauka e hoʻoholo ai i ka nui o ka lāʻau e pono ai e hoʻohana ka mea maʻi. Hana ʻo ia i kēia ma ke kumu o nā loiloi a me nā hualoaʻa.

Eia kekahi, ʻo ka kūlana maʻamau o ka mea maʻi a me ka hele ʻana o nā maʻi concomitant e lawe i nā ʻano.

No laila, lawe ʻia ʻo Krestor e like me kēia:

1. Hoʻopili i kahi papa o ka lāʻau lapaʻau.
2. Manaʻo ʻia ka manawa kūpono loa no ka komo ʻana e ʻike ʻia i ke ahiahi e pili ana me ka nui o ka kiʻekiʻe o ka hoʻouluʻana o ka cholesterol ma ke kino.
3. ʻAʻole make ka ʻai i ka pono o ka lāʻau lapaʻau i lawe ʻia.
4. Ma mua o ka lawe ʻana i kahi papa o ka lāʻau lapaʻau, ua hōʻike ʻia e ka mea maʻi e pili i kahi papaʻai haʻahaʻa ma ka cholesterol.
5. I ka hoʻomaka, pono e lawe i ka lāʻau lapaʻau i ka nui o 5-10 g i kēlā me kēia lā. Eia nō naʻe, ke koho kūʻokoʻa ʻia nei ka helu o ka lāʻau lapaʻau hoʻokahi a ʻo ke kauka. I ka loaʻa ʻole o ka hopena o ka hopena i lawe ʻia, hiki ke hoʻonui ʻia ia i 20 milligrams, akā ma hope o hoʻokahi mahina. ʻO ka nui o ka 40 milligrams e kuhikuhi wale i nā hihia inā he pilikia nui loa ka pilikia o ka hoʻomohala ʻana i nā maʻi cardiovascular. ʻO nā maʻi me ka hypercholesterolemia koʻikoʻi ma lalo o ka mālama mālama olakino e pale aku i nā hopena ʻaoʻao.

Inā he overdose ka mea maʻi o ka lāʻau, ʻaʻole ia e hoʻohana i kekahi antidote, hoʻohana ʻia nā hana kākoʻo.

ʻO nā mea nui nui o Crestor

I ka mākeke hou no nā lāʻau lapaʻau, ua hōʻike ʻia kahi nui o nā lāʻau lapaʻau. Eia naʻe, ma ke ʻano he kānāwai, he nui nā kumukūʻai kumu maoli a ʻaʻole i loaʻa i nā mea maʻi āpau ke kūʻai aku iā lākou.

Ma kēia mea, ua hoʻoholo nā mea hana he nui e hoʻololi i nā kumu me nā analogue. Ma ke ʻano he kānāwai, ka hopena nui ma waena o kēia mau lāʻau ʻo ke kumukūʻai.

Eia kekahi, pono e noʻonoʻo pono i kekahi lāʻau lapaʻau a i ʻole ka hoʻohālikelike pono ia e kuhikuhi e ke kauka nāna e noʻonoʻo i nā hiʻohiʻona āpau o ke ʻano o ka maʻi a me ke kūlana olakino.

Ma waena o nā mea kaulana kaulana:

1. Akorta. Lūkū Lūkini. He kūleʻa ia i ka hoohu, a me nā hōʻike ʻana no ka hoʻohana. Hoʻohana ʻia ia no kahi papa lōʻihi e like me ka mea i kuhikuhi ʻia.
2. Mertenil. ʻO ka kumu hana nui o rosuvastatin. He analogie haole i pili pū i loko o kona mau huahana pharmacological me ka lāʻau lapaʻau mua. Hoʻonui ʻia ma Hungary a kōkua i ka haʻahaʻa cholesterol. Uka - 510-1700 rubles.
3. Rosistark. He paahana pono e kūʻai ʻia ma ke kumukūʻai loa. Ma mua o ka hoʻohana pono ʻia, ua haʻi ʻia e heluhelu ʻoe i nā ʻōkuhi e hōʻemi i ka hopena o ka hopena o ka hopena mai kona hoʻohana. ʻO ke kumukūʻai ma waena o nā awelika mai 250 a 790 mau rubles.
4. Rosucard. ʻO kekahi hoa koa Lūkia. Hoʻohālikelike ka huahana hana, a me ke ʻano ma ka papa hoʻokahi. Contraindicated ma ka hihia o ka naʻau nui o nā mea hana.
5. Rosulip. Ua kūpono ke hoʻohana ʻana i kēia lāʻau lapaʻau ma ka hihia o ka hypercholesterolemia mua, hypertriglyceridemia, e hōʻemi i ka holomua o ka atherosclerosis a me ka pale ʻana o ka maʻi cardiovascular. Kuhi ʻia ia ma Hungary a ma nā kumukūʻai 390-990 mau rubles.
6. Roxer. ʻO ka lāʻau Hypolipidemic. ʻAʻole ia e ʻōlelo i ka wā o ka hapai ʻana, ʻoiai ʻo ka hoʻoulu ʻana, a me nā keiki hoʻi ma lalo o ke 18 mau makahiki. ʻO ke kumukūʻai kumukūʻai ʻo 440-1800 Lūkini mau rubles.
7. Kauoha Pono ka lāʻau lapaʻau e pono no ka liʻiliʻi o 4 mau wiki no ka hopena ʻike. Hana ʻia i loko o ka ʻIseraʻela a i nā kumukūʻai ma kahi o 350-1500 rubles.
8. Novostat. ʻO ka papa hana nui a atorvastatin. ʻO ka lāʻau i hoʻoili ʻia ma Rusia.

Heʻokoʻa ke kumukūʻai o kēia mau lāʻau a ua hoʻololi mai 500 mau rubles i 3 tausani a i ʻole.

Hōʻikeʻike i nā maʻi a me nā kauka e pili ana i ka Crestor

Wahi a ka manaʻo o nā kauka loea, ʻo Krestor i hōʻike ʻia he lāʻau lapaʻau maikaʻi loa ia i kōkua i ka hoʻokaʻawale ʻana i ke kolamu koko.

I ka hapa nui o nā poʻe maʻi e komo ana i ka hoʻokolohua, hele maila ke kuhikuhi o ka cholesterol i loko o ka hebedoma ma hope o ka hebedoma.

ʻO nā papa ma luna o ka mākeke huakaʻi he mea kiʻekiʻe loa, a no laila he ʻoi aku ka maikaʻi o ka hoʻohana ʻana i ka lāʻau. Ma ke ʻano he kānāwai, ʻaʻole ia e hoʻokō i ka hopena o nā hopena.

ʻO ka manaʻo o nā mea maʻi, ua paʻa pū me ka manaʻo o nā kauka. ʻO ka pinepine loa, aia nā manaʻo o nā mea maʻi i loaʻa i ka hōʻeha a i ʻole ka hōʻeha ʻana o ka naʻau.

No laila, hiki iā mākou ke manaʻo i ka maikaʻi loa o ka lāʻau lapaʻau. Mālama wale ia manawa no nā mākaukau e hoʻi i ka maʻamau.

Pono wau e lawe i nā statins e haʻi i ka mea loea i ka wikiō ma kēia ʻatikala.

• Mālama i nā pae o ke kō no ka lōʻihi
• Hoʻihoʻi hou i ka hana insulin pancreatic

Lapaʻau

ʻO kahi ʻaihue hypolipidemic mai ka pūʻulu o nā statins, kahi paʻa o ka HMG-CoA reductase. E like me ke kumu o ka hoʻokūkū antagonism, nā molekini statin nakinaki i kēlā hapa o ka coenzyme A receptor kahi e hoʻopili ai kēia enzyme. ʻO kekahi hapa o ka molekine statin e pale aku i ka hoʻololi ʻana o ka hydroxymethylglutarate i mevalonate, kahi kikowaena o ke kō o nā molekole kolamu.Ke hōʻike nei i ka hana o ka HMG-CoA reductase e alakaʻi i kahi ʻano o ka hopena e pili ana i ka hopena, ka hopena ma kahi o ka hoʻohaʻahaʻa ʻana i ka puna kolu intracellular a me ka hoʻonui ʻana i ka hana o nā mea kū i LDL a, no laila, wikiwiki ka catabolism o LDL cholesterol (Xc).

Hoʻohui ka hopena hypolipidemic o nā statins i ka hoʻemi ʻana i ka pae o ka nui o ka kolamu ma muli o ka LDL cholesterol. ʻO ka emi ʻana o LDL he hilinaʻi i ka dosis a ʻaʻole i laina, akā exponential.

ʻAʻole pili ka poʻokela i ka hana o nā lipoprotein a me nā lipula hepatic, ʻaʻole i hoʻopilikia nui i ka synthesis a me ka catabolism o nā momona momona, no laila, ʻo kā lākou hopena ma ke kiʻekiʻe o TG ma ka lua a ma ʻokoʻa hoʻi ma o kā lākou hopena nui i ka hoʻohaʻahaʻa i ka pae LDL-C. ʻO ka hoʻohaʻahaʻa iki ʻana i ka pae o TG i ka wā o ka mālama ʻana me nā statins e pili pū ana me ka hōʻike o nā koena (apo E) i loaʻa i ka papa o nā hepatocytes i komo i ka catabolism o STD, aia ma kahi o 30% TG.

I ka hopena i nā hopena lipid-lowing, ua loaʻa i nā statins ka hopena maikaʻi i ka hana endothelial (hōʻailona preclinical o ka atherosclerosis mua), ma ka paia vascular, kahi atheroma, hoʻomaikaʻi i nā waiwai rheological i ke koko, loaʻa nā antioxidant, nā waiwai antiproliferative.

Hōʻike ʻia ka hopena therapeutic i loko o hoʻokahi pule. ma hope o ka hoʻomaka ʻana o ka lapaʻau a ma hope o 2 hebedoma o ka mālama ʻana he 90% o ka hopena hiki loa i ka hopena, ka mea i loaʻa e ka 4 wiki a ma hope o ka hoʻomau mau nei.

Nā kumumanaʻo e ka hōʻike a me ke ʻano o ka hoʻohana

Ka ʻokoʻa like, hiki ke pili pū i ka hōʻike a me ke ʻano o ka noi

No ka hana i kahi papa inoa o nā meaʻala maikaʻi loa i nā lāʻau lapaʻau nui, hoʻohana mākou i nā kumukūʻai e hoʻolako ai iā mākou ma mua o 10,000 mau lāʻau lapaʻau ma loko o Rūsia. Hoʻopau hou ʻia ka ʻikepili o nā lāʻau lapaʻau a me kā lākou mea e noiʻi ai i kēlā me kēia lā, no laila ke ʻike mau nei ka ʻike i kā mākou pūnaewele e like me ka wā i loaʻa ai. Inā ʻaʻole ʻoe i ʻike i kahi analogie o kou makemake iā ʻoe, e ʻoluʻolu e hoʻohana i ka huli ʻana ma luna a koho i kahi lāʻau lapaʻau hoihoi iā ʻoe mai ka papa inoa. Ma ka ʻaoʻao o kēlā me kēia o kāu e loaʻa ai nā koho āpau no ka hoʻomohala ʻana i nā lāʻau lapaʻau i makemake ʻia, a me nā kumukūʻai a me nā ʻōlelo a nā lāʻau lapaʻau i loaʻa iā ia.

He aha nā analogue e hiki ke hoʻololi i ka rosuvastatin?

ʻO Rosuvastatin kahi lāʻau lapaʻau i hoʻohanaʻia e hoʻoponopono i nā momona momona. Hoʻohana nui ʻia ka lāʻau lapaʻau no ka pale a me ka mālama ʻana i nā maʻi o ka ʻōnaehana cardiovascular.

ʻO nā mākaukau e pili ana i ka rosuvastatin ma ke ʻano he mea ikaika e hana ʻia e nā mea hana haole a me nā mea hana hale. ʻO ka lāʻau kanu kumu i kapa ʻia ʻo Crestor i hana ʻia ma ka UK e Astra Zeneca. ʻO nā lāʻau i koe i loaʻa i ka rosuvastatin kona mau huahelu.

ʻO ka hoʻohālikelike, ʻo Rosuvastatin Canon, Torvacard, Rosulip, Akorta, Rosistark, Tevastor, Rosart, Rosuvastatin-SZ, Mertenil.

Hiki ke loli iā Rosuvastatin "me kekahi analogue maikaʻi

ʻO ka lāʻau mua a me nā mea hoʻohālike

He aha nā mea kuʻuna a pehea eʻokoʻa ai lākou mai ka kumu? Hoʻopili hou nā Generics nā kope o ka lāʻau mua. ʻO ka hana ikaika i ka lāʻau lapaʻau mua a me nā meaola like ʻole. A ʻokoʻa paha ka loli ʻana o nā mea kōkua.

No ke aha ʻoi aku ka maʻalahi o nā analogues ma mua o ka mea kumu? ʻO ka ʻoiaʻiʻo ʻo ka mea hana i ka huahana mua he "paionia".

Hāʻawi kēia i ke kālā he nui i ka lawe ʻana i nā noi preclinical a me nā lāʻau lapaʻau o ka lāʻau lapaʻau, a loaʻa pū hoʻi ia i kahi patent no kahi lāʻau hou. Hoʻokomo ʻia kēia mau kaʻina hana ma ke kumukūʻai o ka lāʻau lapaʻau.

ʻAʻole halihali nā mea hana maʻamau i nā kumukūʻai koʻikoʻi, hoʻololi hou lākou i ka huahana, hiki iā lākou ke kūʻai aku iā ia ma nā kumukūʻai haʻahaʻa loa.

No laila, e noʻonoʻo i kahi mea lapaʻau e pili pono ana i ka Rosuvastatin (Crestor) mua.

ʻO ka maʻi maʻamau i ka wā o ka mālama ʻana me Krestor e akahele mau

Canu Rosuvastatin

ʻO kekahi lāʻau lapaʻau ʻo Rosuvastatin Canon. Loaʻa ka lāʻau lapaʻau ma ke ʻano o nā papa o 10, 20 a 40 mg. Loaʻa i ka lāʻau lapaʻau nā waiwai lipid. ʻO ka mea noi no ke koho ʻana i ka Canona Rosuvastatin:

• hypercholesterolemia maʻamau,
• hapiliali ailohilol
• hoʻokiʻekiʻe ʻia
• ka pale ʻana o nā hoʻopiʻi o ka atherosclerosis,
• ka pale ʻana o nā hoʻopiʻi IHD me ka ʻole o nā hōʻailona koʻikoʻi,
• hoʻohui i kaʻai i ka mālama ʻana i ka hoʻomohala ʻana i ka atherosclerosis.

Hoʻomaopopo ʻia ka lāʻau lapaʻau e nā papa lōʻihi o ka lāʻau, hoʻomaka me ka palena liʻiliʻi. ʻO 3-4 mau pule ma hope o ka hoʻomaka ʻana o ka hoʻōla, ua kuhikuhi ʻia ka mea maʻi i kahi hoʻāʻo koko e nānā i ka pono o ka mālama ʻana.

Inā kū kiʻekiʻe a pae paha ke kiʻekiʻe o ka cholesterol a me ka triglycerides i ke koko, e hoʻoponopono ʻia ka nui o ka lāʻau.

Ke lawe ʻia nei ka hoʻonui ʻana i ka nui me ka ka wā o ka nānā ʻana i nā helu koko.

ʻO Rosuvastatin Canon - kahi māpuka hypolipidemic mai ka pūʻulu o nā statins, kahi pale o HMG-CoA reductase

I ka hea hea ʻole e kau ʻia ai nā statins?

ʻO Rosuvastatin, e like me nā statins ʻē aʻe, he nui nā contraindications, kahi i pāpā ʻia ai ke kuhikuhi i nā lāʻau lapaʻau o kēia hui.

1. Ke hoʻomanawanui ʻole i nā mea ikaika a i ʻole nā ​​mea waiwai o ka palapala hana.
2. ʻO nā maʻi o ka puʻuwai ma ka hana neʻe a i ka pae kiʻekiʻe o ka transaminases o ka ʻike ʻole ʻia ma mua o 3 mau manawa.
3. ʻO ka wā e lawe ai i ka pēpē a me ka umauma.
4. ʻO ka hemahema o ka lawa ʻole o nā wahine o nā keiki o ka hānau ʻana.
5. ʻO nā maʻi o ka pūpū me nā hōʻike hōʻike o ka maikaʻi ʻole.
6. ʻO nā keiki a me nā ʻōpio i lalo o nā makahiki he 18.
7. Myopathy
8. ʻO ka manawa mālama me ka cyclosporine.

ʻO ka contraindications o ka lāʻau Rosuvastatin Canon e pono e noʻonoʻo i ka wā e koho ai ia. Hōʻalo kēia i ka hoʻomohala ʻana i nā ʻano maikaʻi ʻole mai nā kino nui a me nā ʻōnaehana.

Hiki i nā hoʻopiʻi ka hopena o ka lāʻau rosuvastatin

He aha nā hōʻeha a me nā ulia maikaʻi e hiki ke mālama ʻia me ka wai maoli me nā mea hoʻohuli rosuvastatin? Ua hoʻohaʻahaʻa loa ʻia ʻo Therin therapy. Hoʻopili kēia i nā lāʻau lapaʻau mua a me nā hōʻuluʻulu kālā o nā rosuvastatin.

Hiki i ke hoʻohana ʻana i nā statins ke hōʻeha i ka ʻāʻī o ka ʻāʻī.

Eia nō naʻe, inā he nui ka dosage a i ʻole nā ​​pilikia ma ka ʻaoʻao o nā mea ʻē aʻe a me nā ʻōnaehana, hiki i ka mālama ʻana iā Rosuvastatinomy me nā analogue ke alakaʻi i ka hiʻohiʻona o nā hopena kūlike.

1. ʻO ka edema ʻo Quincke a me nā hopena ʻē aʻe.
2. ʻO nā maʻi o ka pūna endocrine (type 2 diabetes mellitus).
3. Nā maʻi Dyspeptic.
4. ʻO ka ʻaila pancreatic.
5. Nā maʻi ʻaʻai.
6. ʻO ka ʻehaʻeha o ka ʻōpū, myositis, rhabdomyolysis (ka luku ʻana i nā uaua o ka uaua).
7. Hola huehue hana.
8. Nā hoʻololi i loko o ke koko hoʻokaʻawale a me nā hoʻokolohua i ka wai.

Inā ʻike ʻoe i kekahi mau hōʻailona ʻaʻole i hōʻailona i ka maʻi lalo, pono e kiʻi koke ʻoe i ke kauka. E hoʻoholo pololei ʻo ka loea i ke kumu mai o ka maʻi a, inā pono, hoʻoponopono i ka hoʻoponopono lāʻau a me ka dosage.

Nā rula no ka lawe ʻana i nā lāʻau

Pehea e lawe ai iā Rosuvastatin a me nā mea hoʻohālike? Hāʻawi ka lāʻau lapaʻau kūpono i ka hopena therapeutic kiʻekiʻe loa a me ka hōʻemi ʻana i nā pilikia o nā ʻōpiopio o luna nei. No laila, ʻo nā kānāwai kumu o ka mālamaʻana e like me kēia.

1. Pono ka laʻa e lawe ʻia ma ke ʻano he ʻokoʻa, ʻaʻohe ʻōmaʻomaʻo. E inu i ka lāʻau lapaʻau me ka wai maʻalahi i ka nui o ka nui.
2. Inā makemake ʻoe e lawe i ka liʻiliʻi liʻiliʻi ma mua o kahi papa hoʻokahi, hiki ke hoʻokaʻawale i ke ʻano dosage i ka hapalua.
3. Pono nā wahine o nā makahiki hānau i ka wā hapai e hoʻohana i nā ala kūpono o ka contraception.
4. I ka hihia o ka hāpai ʻana i ka wā e mālama ai me nā statins, pono e hoʻokuʻu ʻia ka lāʻau lapaʻau. ʻAʻole koi ʻia ka male ʻana.
5. I ka wā o ka papa hana, ua pāpā ʻia i ka hoʻokiʻoki ʻana a hoʻonui ʻana i ka lā i kēlā lā i kēia lā i ka lāʻau.
6. Inā he hala ʻole ka lāʻau lapaʻau, pono e hoʻomau i nā lāʻau lapaʻau e like me ke ʻano maʻamau.

ʻAʻole ʻōlelo nā loea i ka lawe ʻana i nā statins i kā lākou iho

Pono e hoʻomanaʻo ʻia ma ke ʻano o ka mālama ʻana o statin, pono ʻoe e hahai i ka ʻai haʻahaʻa ma ka momona a me ka cholesterol. Pono ka haʻahaʻa o ka meaʻai i nā caloli, aia nā mea holoholona liʻiliʻi e like me ka mea hiki.

ʻO nā ʻano momona o nā iʻa, nā ʻiʻo a me nā huahana waiū e pono e hoʻopau loa. Pono ka komo ʻana i ka wai momona a me ka momona o ka mea kanu.

E like me nā meaʻai o ka protein, nā ʻiʻo moa, ka pipi, ke kīwī, nā waiū haʻahaʻa e kūpono.

Pono ʻoe e ʻai i nā meaʻai ʻē aʻe, nā huaʻai, nā mea kanu, nā wai momona hou. Hōʻalo i ka ʻai ʻana i ka momona, ke kālai ʻia a me ka uahi mau mea. Waiho i ka waiʻona, ka wikiwiki wikiwiki a me ka pākī.

Hiki iā ʻoe ke kuke me ka pālua i ka pālua, ma ka pāwī, i hoʻolapalapa. Paipai ʻia ʻole e hoʻohana i nā aila, nā mea ʻala a me nā mea wela i ka kuke ʻana.

ʻO ka hoʻokō ʻana me nā rula o ka hānai e hoʻoholo nui ana i ka kūleʻa o ka mālama ʻana.

Ma ke ʻano lāʻau maikaʻi loa?

No laila, ʻo ka hoʻi ʻana i nā mea hoʻohālike o Rosuvastatin, pono e ʻōlelo ʻia e loli maikaʻi i ka lāʻau lapaʻau mua. A eia, ʻoi aku ka maikaʻi - ka mea kumu a mua ʻole paha? Loaʻa hiki ʻole ke pane i ka nīnau, no ka mea, he ʻokoʻa nā manaʻo o nā loea i kēia pili.

Manaʻo kekahi poʻe he maʻemaʻe ka mea maʻamau "a ua maʻalahi hoʻi e hoʻonā i nā hopena i makemake ʻole ʻia. Eia kekahi, ʻike kekahi mau kauka i ka ʻoihana kiʻekiʻe o ka mea mua ma mua o nā hoa.

No laila, hiki i ke kauka ke alakaʻi i nā ʻano noʻonoʻo like ʻole, e kuhikuhi ana i ka mea maʻi i ka ʻola mua a me nā hua like ʻole.

ʻO kahi loiloi hōkeo o nā mea kaulana kaulana a me ka uku hoʻi o ka lāʻau lapaʻau "Rosuvastatin"

ʻO Rosuvastatin kekahi o nā lāʻau lapaʻau lipid-ka haʻahaʻa a me ka hoʻohana nui. Inā no kekahi mau kumu, no ka laʻana, ʻo ka nele o kahi kīhāpai a i ʻole ke kumukūʻai koʻikoʻi, ʻaʻole hiki i ka mea maʻi ke kūʻai i ka lāʻau lapaʻau mua, a laila hiki ke hoʻololi ʻia me kahi alapi e like me ke ʻano, he nui nā Rosuvastatin.

ʻO ka ʻike nui e pili ana i ka lāʻau lapaʻau a me nā kuhikuhi i ka hoʻohana

Rosuvastatin (Rosuvastatin) - Eia kēia lāʻau lapaʻau lipid-kaila o ka hanauna o ka makahiki IV hou (hou) mai kahi pūʻulu farmacological nui o nā statins, nā mea ikaika i nā mea kanu o nā inoa rosuvastatin i ke ʻano o ka paʻakai paʻakai (kalepona rosuvastatin).

Pono ʻia kēia lāʻau lapaʻau no ka hoʻoponopono ʻana i ka cholesterol kiʻekiʻe mau (hypercholesterolemia), ʻaʻole hiki ke mālama ʻia me nā ʻano lāʻau ʻole. Ua kuhikuhi ʻia nō ia ma ke ʻano o ka hōʻiliʻili paʻakikī o nā ʻano maʻi ʻē aʻe o ka hanu o ka ʻaihue (dyslipidemia), no ka pale ʻana o nā hōʻeha cardiovascular a me ka wehe ʻana o nā hoʻololi atherosclerotic ma nā paia o nā moku koko.

Hoʻokumu ka hana o nā statins i ka pale ʻana i ka hoʻoneʻe o ka enzyme, nona ke kuleana no ka hoʻokumu ʻana o ka kolamu ma ka ate (he kumu no kahi 80% o ka waiwai).

Nā hana hana i ka hana Hoʻopili ʻo Rosuvastatin i ka pani ʻana i ka enzyme - HMG-CoA reductase, ʻo ia ka "progenitor" o ke ʻano o ka endogenous synthesis (Chol, cholesterol) ma ka puʻuwai. Ma muli o kēia, hoʻonui ka nui o nā mea i hoʻokae i ka lipoproteins haʻahaʻa haʻahaʻa, ka mea e hoʻowalewale i ke kaʻina o kā lākou maluhia a me ka excretion mai ke kino.

ʻO kahi hopena, e pili ana i ke kāwili o ka hoʻohana o ka lāʻau lapaʻau, ke emi nei ka nui o ka neʻe ʻana o ka "bad" kolesterol (LDL, LDL), a me ke pae o ka "maikaʻi" kolamu (HDL, HDL) i ke koko me ka hoʻonui hou aʻe i ka uku uku.

Loaʻa ka lāʻau lapaʻau i ke ʻano o nā papa kiʻi ʻoniʻoni, pono e hoʻopau ʻia wale nō i loko (orally), me ka liʻiliʻi o 100-150 ml wai, i kēlā me kēia manawa o ke ao, ʻaʻohe o ka meaʻai.

ʻO ka hui kumu o Rosuvastatin e loaʻa ana i ka waiu waiu (lactose) monohala, ka mea i hiki ai i ka lāʻau lapaʻau ke hiki ke loaʻa i nā mea maʻi me ka hoʻomehana kū hoʻokahi o kēia māhele a me nā poʻe me ka nele o ka lactase.

Huaʻa noho hoʻoponopono Koho ia ʻo Rosuvastatin e ke kauka i ke kū hoʻokahi, e pili ana i ka paʻakikī i kēlā me kēia hihia. Hoʻomaka ka hoʻomakaʻana me ka maʻa liʻiliʻi (5-10 mg hoʻokahi manawa i ka lā) a hoʻonui e like me ka mea e pono ai (hāʻawi ʻia ʻole nā ​​hopena lāʻau).

Hiki ke ʻike ʻia ka hopena lipid-kahe ʻana ma hope o 7-9 mau lā ma hope o ka hoʻomaka ʻana o ka hoʻomaʻamaʻa ʻana, a ma hope o 2 hebedoma he hiki i ka 90-100% o ka hopena hiki loa i mālama ʻia ma nā papa holoʻokoʻa o ka hana maʻamau o Rosuvastatin.

ʻOi aku ka maikaʻi o nā mea hana?

Ua hoʻomohala ʻia ka lāʻau lapaʻau mua ʻo Rosuvastatin e ka hui ʻo Japanese i ka ʻo Shionogi & Co. (Shionogi & Co), eia nō naʻe, ke hoʻopili ʻia nei nā analogues ma lalo o ka inoa non-proprietary international (INN) e nā hui lāʻau lapaʻau hou:

• Lūkia - Lōkana (Phstandard), Ozone (Ozon), Canonfarma (Kanonfarma), FI Obolenskoye (OBL Pākaʻaka),
• haole - Astra Zeneca (Astra Zeneca), Gideon Richter (Gedeon Richter), Actavis (Actavis), Belupo (Belupo).

Kūpono kēia mau hui āpau i nā generics, i.e., kope kope i ka mea ola, ʻo ka mea hana i hana ʻia ka rosuvastatin like ʻole, akā ʻokoʻa lākou i ka hoʻokumu mua ʻana e ka laina ʻenehana hana o ka hana, inoa inoa a me ka hoʻohalike o nā mea hoʻohiki.

No ka mea like like me nā kikoʻī pololei like i ka mea mua, mai ka manaʻo mai o kona kūpono, ʻaʻole ia e manaʻo i ka ʻoihana e hāʻawi i ka makemake i ka wā e kūʻai aku ai, akā aia ke kūʻai ʻia ʻo Rosuvastatin no ka manawa lōʻihi, ʻo ia ke ʻano e noʻonoʻo pono ai i nā lāʻau ʻinike mea kūʻai aku.

ʻO nā mea waiwai kaulana a me nā hili no rosuvastatin

Ma mua o ka noʻonoʻo ʻana i nā mea kikoʻī a me nā mea pili no Rosuvastatin, pono e hoʻomaopopo ʻia, ʻoiai ke koho ʻia he kauka, ʻae i ka mea maʻi ke koho i nā ʻano kuʻuna kūpono, e kālele ana i kāna makemake iho, ka peke a me ka hoʻomākeʻakeʻe pilikino i nā mea hoʻohui ʻē aʻe i ka ʻano. ʻO ka mea nui ke hoʻokō me ka ʻōlelo a me ka regimen e hōʻike ana i ka lāʻau.

He pākuʻi ikaika ʻo Roxera, e ʻae ʻia ka rosuvastatin e hoʻokuʻu wale ʻia i loko o ka ʻōpū liʻiliʻi, kahi e hoʻokomo ai nā papa i ka loli ʻole, a i ʻole ia i ka hopena luku ʻia o ka wai ʻōpū.

Nā hiʻohiʻona o ka manaʻona: Hoʻonui a butyl methacrylate a me methyl methacrylate copolymers i ka ua.

ʻOihana hana: KRKA, Slovenia.

Nā kumukūʻai lāʻau: mai 383 RUB / 30 pcs 5 mg a 1617 mau rubles / 90 pcs. 20 mg i kēlā me kēia.

Hōʻike ʻia ʻo Rosucard (Rozucard) i ka bioavailability maikaʻi (ma mua o 20%), akā ʻo ka mea ikaika ma ka rosuvastatin e hana maʻalahi ia mai ke kino, a no laila ua loaʻa ka hopena i ka hopena therapeutic.

Nā hiʻohiʻona o ka manaʻona: i ʻole o ka hypromellose mai ka hoʻopuka mua ʻana, ua hoʻohana ʻia ka croscarmellose e like me ka pauku palaoa.

ʻOihana hana: Zentiva, pae Repubalika.

Nā kumukūʻai lāʻau: mai 613 kahaki. / 30 pcs. 10 mg kēlā me kēia i ka 2708 rub./90 pcs. 40 mg pākahi.

Kaukaʻi nā kauka

E hoʻohaʻahaʻa pono i ka cholesterol a pale i ka atherosclerosis me nā hoʻopiʻi ʻaoʻao, hōʻike nā mea loea i ka choledol. Nā lāʻau lapaʻau hou:

• ka mea i pili i ka amaranth i hoʻohanaʻia i ka mālama ʻana i ka maʻi cardiovascular,
• hoʻonui i ka hana o ka kolamu "maikaʻi", hoʻemi i ka hana o "kino" i ke kino,
• ka hoʻohaʻahaʻa nui ʻana i ka hōʻeha o ka hōʻeha ʻana a me ka puʻuwai,
• hoʻomaka ka hana ma hope o 10 mau minuke, ʻike ʻia kahi hopena koʻikoʻi ma hope o nā hebedoma 3-4.

Hōʻoiaʻiʻo ʻia ka hoʻomaʻamaʻa ʻana e ka hoʻomaʻamaʻa lāʻau a me ka noiʻi ʻana o ka Institute Institute of Therapy.

ʻO Mertenil (Mertenil) kahi kiʻekiʻe i ka hoʻomaʻemaʻeʻana o ka mea ikaika. Mālama kēia i ka maikaʻi o ka lāʻau i ka liʻiliʻi me nā hopena liʻiliʻi, ʻo ia ka mea nui i ka wā e lawe ai i ka rosuvastatin i nā maʻi maʻi.

Nā hiʻohiʻona o ka manaʻona: pili i nā mea mua, koe wale nō nā mea i hoʻohana ʻia no ka pena ʻana i ka pōpoki.

ʻOihana hana: Gedeon Richter, Hanau.

Nā kumukūʻai i nā lāʻau lapaʻau: mai 478 kahalaha. / 30 pcs. 5 mg a 1439 mau rubles / 30 pcs. 40 mg pākahi.

ʻO Rosulip (Rosulip) kahi mea hoʻohālike haʻahaʻa o Rosuvastatin, he mau bioavailability kiʻekiʻe a hōʻiliʻili mālie, kahi e hiki ai iā ʻoe ke hana liʻiliʻi i ka hopena therapeutic i makemake ʻia o ka mea ikaika ma ke kino.

Nā hiʻohiʻona o ka manaʻona: kū i ka rosuvastatin ʻaʻole i ke ʻano o ka calcium, akā ma ke ʻano o ka paʻakai paʻakai (rosuvastatin zinc).

ʻOihana hana: EGIS (EGIS Pharmaceuticals PLC), Honu.

Nā kumukūʻai lāʻau: mai 469 RUB / 28 pcs 5 mg a 1087 mau rubles / 28 pcs. 20 mg i kēlā me kēia.

Crestor (Crestor) - hoʻokahi wale nō o ka lāʻau lapaʻau i hoʻokumu ʻia ma ka rosuvastatin. Hōʻike ʻia kēia lāʻau lapaʻau e ka hoʻonaʻauao kiʻekiʻe me ka hoʻoili o ka mea hana a, inā hilinaʻi ʻoe i ka ʻōlelo hoʻomanawanui, ʻoi aku ka maikaʻi, akā i ke kumukūʻai ʻoi aku ka maikaʻi ma mua o nā mea hoʻonā'ē aʻe.

Nā hiʻohiʻona o ka manaʻona: Kūlike nā mea a pau i ke ʻano kumu mua.

ʻOihana hana: Astra Zeneca, Ke Aupuni o ka United Kingdom.

Nā kumukūʻai i nā lāʻau lapaʻau: mai 1756 kahū. / 28 pcs. 5 mg kēlā me kēia no 5036 rub./28 mau pcs. 40 mg pākahi.

ʻO Tevastor kekahi o nā moʻoʻoniʻoni maikaʻi loa o Rosuvastatin, no ka mea, e hoʻopili koke ana i loko o ke kino, e kau ana i kahi hopena therapeutic i haʻi ʻia, a ma ka manawa like ʻoi aku ka uku ma mua o ka lāʻau lapaʻau mua.

Nā hiʻohiʻona o ka manaʻona: aneane like me ka lenten e like me ka mua (koe wale ke dye).

ʻOihana hana: TEVA (TEVA Pharmaceutical Industries Ltd), ʻIseraʻela.

Nā kumukūʻai lāʻau: mai 341 kahakaha. / 30 pcs. 5 mg a 1522 mau rubles / 90 pcs. 20 mg i kēlā me kēia.

Rosuvastatin-SZ

Rosuvastatin-SZ (Rosuvastatin-SZ) - i kēia lā ʻo ia ke hoʻololi pono loa no Rosuvastatin mai kahi mea hana Rusia. ʻOiai ke kumukūʻai haʻahaʻa loa, ʻaʻole ia i haʻahaʻa ma mua o ka mea i nā huahana ʻē aʻe a he waiwai nō hoʻi ia i ka waiwai.

Nā hiʻohiʻona o ka manaʻona: oxide ironide e hoʻohana ʻia ma kahi ʻano i kahi manu i hoʻololi ʻia e ka alumini varnish o ʻekolu mau ʻano ʻokoʻa.

ʻOihana hana: FC Severnaya Zvezda ZAO, Rusia

Nā kumukūʻai lāʻau: mai 178 kahaki. / 30pcs. 5 mg a 684 mau rubles / 30 pcs. 40 mg pākahi.

Hoʻohui i nā statins, aia kekahi ala ʻē aʻe. Koi aku ka poʻe heluhelu ʻO ka hoʻōla kūlohelohe, kahi i hui pū me ka meaʻai a me nā hana, hoʻemi nui ʻia ka kolamu ma hope o 3-4 pule. ʻO ka manaʻo o nā kauka >>

Loaʻa iā Rosart (Rosart) nā pono āpau i ka lāʻau lapaʻau mua a loaʻa pinepine kahi hopena maikaʻiʻole i ke kino, no ka mea ua hoʻomaʻemaʻe pono ʻia nā mea ikaika a me nā mea kōkua. Hiki iā mākou ke ʻōlelo, ʻo ia ka mea pono pinepine loa no ka rosuvastatin.

Nā hiʻohiʻona o ka manaʻona: Ua like nā mea a pau me ka hoʻomākaukau i ka mākaukau mua.

ʻOihana hana: Actavis Group, Kahiki

Nā kumukūʻai i nā lāʻau lapaʻau: mai 426 RUB / 30 pcs 5 mg a 2347 rub./90 pcs. 40 mg pākahi.
ʻO nā huahana e hoʻohaʻahaʻa i ka kolamu a hoʻomaʻemaʻe i nā moku koko.

ʻO nā lāʻau lapaʻau maikaʻi loa pau loa no ke kolamu kiʻekiʻe ma ke ʻano o nā papa.

Nā analogue hou a me nā waiwai no ka lāʻau crossor no nā keiki a me nā pākeke

ʻO ka lāʻau lapaʻau Krestor he lipid-hoʻemi haʻahaʻa i pili i ka hui o satins.

ʻO ka mea hoʻōla no ka rosuvastatin, ka mea e hoʻohaʻahaʻa i ka nui o ka kolamu, e hoʻopau ana i ka disotunction endothelial i ka atherosclerosis mua, hoʻomaikaʻi i ke ʻano o nā paia o nā kīʻaha koko, ke ʻano o ka atheroma, a me nā hana rheological o ke koko. Hoʻomaopopo ka Antioxidant a me nā hopena antiproliferative ma ke kino.

ʻO nā hōʻailona no ka hoʻohana ʻana me ke ʻano o ka hypercholesterolemia, e pili ana i ka homozygous familial. ʻO nā huaʻōlelo no ka lāʻau lapaʻau e like me kēia: ʻo ka hapai, lactation, ka wā kamaliʻi a me ka wā'ōpiopio a hiki i nā makahiki 18, ka maʻi o ka ate, nā maʻi o ka lā ma ka hana ikaika.

ʻO ka lāʻau lapaʻau i hana ʻia ma UK a me Puerto Rico he mau mea pili a me ka ʻano hoʻi. ʻAʻole i loaʻa nā kumukūʻai o nā papa Krestor i kēlā me kēia mea maʻi: 800-9800 rubles. ʻO nā mea hou aku o nā lāʻau lapaʻau e hana ʻia e nā mea hana kūloko a me nā mea hana ʻē aʻe.

Nā kuʻuna o ka hana Lūkia

Nā mea hoʻohalike o Ukrainian

Pehea e hoʻololi ai i ka crossor lāʻau, inā pono ʻoe e koho i kahi like me nā mea kūʻai aku i ka hopena. ʻO nā lāʻau lapaʻau Ukrainian kūpono loa e komo i ka papa inoa ma lalo nei.

• Klivas. ^ E Ha yM. ʻO ka hoʻohālikelike maʻalahi o ke keʻa ma ke ʻano o nā papa. Ka hoʻonohonoho pono o ka lāʻau me ka rosuvastatin. Hoʻohana maikaʻi ka lāʻau lapaʻau i ke kūlana o ka hypercholesterolemia, a hoʻohana pū ʻia i ka pale ʻana o nā maʻi ʻo ka maʻi cardiovascular. ʻO ka awelika kumukūʻai he 10-155 rubles.
• Atorvacor. ^ E Ha yM. Hoʻopili ke Atorvastatin i ke ʻano o ka lāʻau lapaʻau i ka hopena lipid-lowing, e hoʻemi ana i ka cholesterol cholesterol. ʻO kahi o ka hana a ka lāʻau lapaʻau nā pehu ʻili, no laila, i waena o nā contraindications ma ke ʻano o ka hōʻino ʻana o ka ʻōpū. ʻO ka awelika kumukūʻai ʻo 140-220 mau rubles.

Generics Belarusian

ʻO nā generics cross Belarus kahi hoʻololi kūpono loa no ka lāʻau lapaʻau haʻahaʻa lipid liʻiliʻi me ka ʻikepili like i ka ʻōlelo i hoʻohana ʻia.

Hōʻike ʻia ka papa ʻaina ma lalo nei

Nā huaʻōlelo ʻē aʻe o nā haole

ʻO nā hua mele i nā ʻenehana hou o kēia ke kumu e pili ana i ka rosuvastatin:

• Mertenil. ^ E Ha yM. ʻO ka mea hoʻonaninani ka rosuvastatin. ʻO nā ʻōkuhi no ka kuhikuhi ʻana i ka lāʻau ka hopena i nā kūlana dyslipidemic e hoʻohaʻahaʻa i ka cholesterol. ʻO ka'āina kahi - Hungary. ʻO ka awelika kumukūʻai he 510-1700 rubles.
• Rosistark. ^ E Ha yM. ʻO kahi lāʻau lapaʻau hoʻopihapiha kūpono e pili ana i ka rosuvastatin ma ke kumukūʻai kūʻai. A manaʻo ʻia e heluhelu ʻoe i nā ʻōlelo aʻo no ka hoʻohana ʻana no nā contraindications, nā hopena pili a me nā kūlana e koi ai i ka mālama ʻana i ka wā o ka therapy. ʻO ka kumu kumukūʻai he 250-790 rubles.
• Kauoha. ^ E Ha yM. He hōʻailona like no ka lāʻau lapaʻau i ka nīnau me kahi ʻano hana like. Lawe ʻia ka lāʻau lapaʻau i kahi manawa lōʻihi - ka mālama ʻia ʻana o ka hopena therapeutic ma hope o 4 mau pule ma hope o ka hoʻomaka ʻana o ka lawe ʻana. ʻO ka kumu kumukūʻai he 350-1500 rubles.
• Roxer. ^ E Ha yM. ʻO kahi mea lawelawe e hoʻihoʻi i ka lipid me kahi mea ikaika e like me ke kea. Ke papa ʻia ka lāʻau lapaʻau i ka wā o ka hapai, ka hoʻoulu ʻana, nā keiki ma lalo o nā makahiki 18. ʻO ka hoʻokalakupua ʻO Slovenian ka hoʻokuʻu. ʻO ke kumukūʻai kumukūʻai ʻo 440-1800 rubles.
• Rosulip. ^ E Ha yM. ʻO ka papaʻaina me ka rosuvastatin i ka hoʻopalapula, e hoʻemi i ka hoʻomohala o ka kolamu nui i loko o ke koko koko.ʻO ka hoʻohana ʻana i ka lāʻau lapaʻau ka mea nui no ka hypercholesterolemia primera, hypertriglyceridemia, hypercholesterolemia homozygous, e pale ai i ka hoʻomohala ʻana o ka atherosclerosis, a ma ka mālama ʻana nō hoʻi i ka mālama ʻana o nā maʻi cardiovascular. ʻO ke kumukūʻai kumukūʻai he 380-1990 mau rubles.

Eʻoluʻolu, e hiki i nā mea hoʻohana lāʻau lapaʻau ke loaʻa nā ikaika o nā hopena therapeutic ma ke kino o kēlā me kēia maʻi. I nā ʻōlelo e hoʻohana ai, hiki ke hōʻike ʻia nā ʻano hoʻohālikelike a me nā contraindications. Hiki i ke kauka ke kuhikuhi i kahi lāʻau lapa-lipid-lowing.

Ma muli o ke ʻano o ke keʻe e hoʻohālikelike ai, no laila, ʻaʻole ʻoe e komo i nā hana e pono ai ka nui o ka makaʻala.

Ke aʻo ʻana o Crestor

NA ININA
no ka hoʻohana lāʻau ʻana i ka lāʻau
K ʻAHUI

Ka hana lāʻau lapaʻau
ʻO Crestor kahi mea mālama lipid-hoʻohaʻahaʻa. ʻO ka mea hana ikaika o ka lāʻau ʻo rosuvastatin - kahi pale hoʻoneʻe hoʻoneʻe no HMG-CoA reductase, he enzyme e hoʻololi i ka 3-hydroxy 3-methylglutaryl coenzyme A i ka mea mua o ke kolamu - mevalonate. ʻO kahi o ka noi o ka hana a rosuvastatin ka peʻa, kahi i loaʻa ai ka catabolism o nā lipoproteins low density (LDL) a me ka hoʻokumuʻana o cholesterol (CS). Hoʻonui ʻo Rosuvastatin i ka nui o nā receptors hepatic no nā lipoproteins haʻahaʻa haʻahaʻa ma nā membranes, e alakaʻi ai i ka catabolism a me ka piʻi ʻana o nā lipoproteins haʻahaʻa haʻahaʻa a me ka pale ʻana i ka hoʻokumu ʻana i nā lipoproteins density haʻahaʻa (VLDL). A ʻo kahi hopena, aia ka emi ʻana o nā mea o nā lipoproteins haʻahaʻa haʻahaʻa a haʻahaʻa loa.
Hoʻopau ʻo Rosuvastatin i nā pae kiʻekiʻe o ka kolamu, triglycerides a me LDL kolesterol, apolipoprotein B (ApoV), VLDL cholesterol, non-HDL cholesterol, VLDL cholesterol, huakaʻi LDL cholesterol / HDL cholesterol, ka nui LDL cholesterol / LDL / C I. Hoʻonui iki ʻo Rosuvastatin i ka ʻike o ka HDL cholesterol a me ApoA-I (apolipoprotein A-I).
Hoʻoulu ka hopena kiʻekiʻe o Krestor ma hope o 21 mau lā o ke komo a hoʻomau mau ʻia. Ma hope o 7 mau lā o ka lawe ʻana i ka lāʻau lapaʻau, ʻike ʻia ka hopena therapeutic o Krestor, a ma hope o 14 mau lā o ka lawe ʻana i ka lāʻau lapaʻau, ʻo ka hopena o ka lāʻau ka 90% o ka hiki.
Ua hoʻomaopopo ʻia ka lāʻau lapaʻau no nā pākeke me ʻole a me ke ʻano hypertriglyceridemia a me ka hypercholesterolemia, ʻaʻohe manaʻo o ke ʻano, ka wahine a me ka lāhui. Hiki ke hoʻohana ʻia ka lāʻau lapaʻau i nā mea maʻi me ka famchial hypercholesterolemia a i ʻole diabetes mellitus.
ʻOiai e lawe ana iā Krestor ma kahi helu o 10 mg ma ka 80% o nā mea maʻi me ka awelika kiʻekiʻe o ka kolamu LDL o 4.8 mmol / L (hypercholesterolemia IIa a i nā ʻano), he hōʻemi i ka LDL cholesterol i ≤3 mmol / L ua nānā ʻia.I ka poʻe maʻi me ka hypercholesterolemia familial e loaʻa ana i ka lāʻau lapaʻau ma ke kaʻe o 2080 mg, ua ʻike ʻia kahi hoʻololi maikaʻi i ka ʻōlelo lipid (ua mālama ʻia kahi hōʻike noiʻi me ke komo ʻana o nā mea maʻi 435).
ʻO ka emi ʻana o ka cholesterol LDL ma ka 53% i nānā me ka terapi Crestor 12-wiki ma hope o ka titration o kahi maʻa o 40 mg / lā, a me ka pae o LDL cholesterol o ≤3 mmol / L i loaʻa i ka 33% o nā mea maʻi. I ka poʻe maʻi me ka famchial homozygous hypercholesterolemia, ua kauoha ʻia ka lāʻau lapaʻau ma ke ʻano o 20 me 40 mg, a ma ke kūpaʻa ʻana e pili ana i ka hoʻōla ʻana o Krestor, ʻo ka hāʻule o ka LDL cholesterol i ka 22%.
Ke hui pū ʻia me ka fenofibrate, ua hoʻopaʻa ʻia kahi hopena hoʻohui (triglyceride level), kahi i nānā ʻia i ka wā i hui pū ʻia me ka acid nicotinic (e pili ana i ka HDL cholesterol).
ʻOiai ʻaʻohe ʻikepili e loiloi i ka hōʻemi o ka nui o nā hoʻopiʻi i hoʻokumu ʻia e nā maʻi profile lipid (no ka laʻana, ka maʻi naʻau coronary) e hoʻomau ʻia nei nā hoʻokolohua maʻi.
Ka ʻike nui loa o ka waiwai ikaika i ka plasma koko e nānā ʻia ma kahi o 5 mau hola ma hope o ka hoʻohana pono ʻana o Krestor. ʻO ka bioavailability e pili ana i ka 20%. Kumumau i loko o ke akea. ʻO ka nui o ka hoʻolahaʻana o ka rosuvastatin he 134 lita. Ma kahi o 90% o nā kūleʻa i hoʻokele ʻia e hoʻopaʻa ʻia e nā protein plasma (albumin).
Ma kahi o 10% o kahi momona o ka rosuvastatin e hana i ka metabolism palena. ʻO Rosuvastatin kahi mea kīʻaha ʻole o ka metabolism e ka pūnaehana cytochrome P450. ʻO ka enzyme nui e hoʻopili ana i ka rosuvastatin ʻo CYP 2C9. I kahi liʻiliʻi, ʻo nā enzymes CYP 3A4, CYP 2C19 a me CYP 2D6 e komo i ka metabolism o rosuvastatin. ʻO nā metabolits koʻikoʻi o ka waiwai hana nā metabolite lactone a me N-dismethyl. Ke hoʻohālikelike nei iā lākou, ua kuhi ʻia ʻo N-dismethyl o ka hapalua (50%) ʻaʻole ikaika i ka rosuvastatin. Ua hoʻoholo ʻia ʻo ka metabolite lactone o ka ʻohiʻohana me ka lāʻau lapaʻau.
ʻO ka awelika o ka ʻalani geometric o ka rosuvastatin he 50 l / h me ka coefficient o ka ʻano o 21.7% Kahi ʻia a ʻo ka 90% o ka inika i hoʻolele ʻia e hoʻololi ʻia e nā ʻōpū me nā feces, ʻo nā rosuvastatin a i ʻole hoʻopili ʻia a hoʻoneʻe ʻia ka excreted. ʻO ka 10% o ka waiwai ka hoʻopau ʻia e nā keiki. ʻO ka hapalua hapalua he 19 mau hola, ʻo ia mau me ka hoʻonui ʻana i ka nui. Ma ke kaʻina o ka hepatic uptake o ka molekela ʻoi aku o ka waiwai (e like me nā HMG-CoA reductase inhibitors), kahi koloka transporter e komo ana i ka hana nui ma ka wehe ʻana o ka rosuvastatin e ka pepeka.
Ka hoʻonui ʻia o ka ʻōnaehana o ka rosuvastatin ka pānaʻi ʻana i ka nui e lawelawe ʻia ai. I ka hihia o ka lawe ʻana i kekahi mau dona o kēlā me kēia lā i ka lāʻau, ʻaʻole i loli nā kāla lāʻau pharmacokinetic o nā mea ikaika o Krestor.
A hōʻike hoʻohālikelike i ka poʻe maʻi e noho ana ma Asia (iwi Asia) i hōʻike i ka nui o AUC a me ka hoʻonui ʻana i ka nui o ka nui o ka rosuvastatin e 2 manawa, ke hoʻohālikelike ʻia nei me ka ʻikepili mai ka poʻe ʻEulopa e noho nei i ʻEulopa a me Asia. ʻAʻole i ʻike ʻia ka hopena o nā mea kūlohelohe a me nā mea kikoʻī i ka hopena i hopena i ka ʻokoʻa i ka lāʻau pharmacokinetic. ʻAʻole i ʻike ʻia nā ʻokoʻa koʻikoʻi o ka maʻi ma waena o nā mea maʻi o nā lāhui Negroid a me Caucasoid i nā pharmacokinetics o rosuvastatin.
I ka hihia o ka hana renal impaired (pūleʻa a i ʻole), ʻaʻole i loli nui ka ʻike o ka plasma o ka rosuvastatin a me kāna metabolite hoʻoikaika (N-dismethyl). I ka hana ʻole o ka renal me ka hōʻoki ʻana o ka pae ma kahi o ≤30 ml / min, ka piʻi ʻana o ka plasma o ka waiwai hana 3 mau manawa (a me ka metabolite ikaika, N-dismethyl, hoʻonui 9 mau manawa). ʻO ka plasma o ka rosuvastatin i loko o nā mea maʻi e loaʻa ana i ka hemodialysis maʻi ʻoi aku ma kahi o 50% nui aʻe. ʻO kahi haʻawina o nā pākuhi pharmacokinetic o rosuvastatin i nā poʻe maʻi me ka maʻi maʻi e hana ʻia i hoʻohālikelike ʻia me kahi pūʻulu olakino olakino.
ʻAʻole i hoʻonui iki i nā ʻāpana o ka hapalua-ola o ka mea hana i loko o nā poʻe maʻi me nā ʻano like ʻole o ka hina o ka nui, i helu ʻia ma nā keiki-Pugh nui a 7 a i ʻole nā ​​kikoʻe. Pahuʻi nā poʻomanaʻo 8 a me 9 i ke kiʻekiʻe ʻo Child-Pugh i hōʻike i ka hoʻonui o ka hoʻopau ʻana i ka hapalua-ola ma o ka manawa he 2. ʻAʻoheʻike i ka hoʻohana ʻana o rosuvastatin i nā mea maʻi me ka hepatic insufficiency me kahi keiki-Pugh mea he 9 a keu paha.

Nā hōʻailona no ka hoʻohana ʻana
· Kauʻana o ka atherosclerosis e lohi i ka holomua o ka maʻi i nā poʻe maʻi e hōʻike ʻia ana o ka mālama lipid-hoʻēmi ʻana;
Ma ka hihia o ka hypercholesterolemia homozygous i hoʻohui ʻia i kekahi hana lapaʻau hoʻohaʻahaʻa ʻē aʻe (no ka laʻana, ʻo LDL-apheresis) a me ka meaʻai paha, a ma nā hihia i like ʻole ka maikaʻi o kēia ʻano maʻi.
· Hoʻohui pū kekahi me ka meaʻai - me ka hypercholesterolemia i hui ʻia (type IIB) i ka hihia inā i ke ʻano ʻole o ka pharmacological (ʻoi ka lilo ʻana, ka hana kino) a me ke hoʻololi ʻana i ka mea ʻai e pono ai,
ʻO ka ʻano pae IIa hypercholesterolemia (ma loko o ka heterzygous hypercholesterolemia ʻohana).

Ke ʻano o ka noi
Hoʻohana waha ʻia ka lāʻau lapaʻau, holoi ʻia me ka wai, i kēlā me kēia manawa o ka lā, me ke ʻano o ka ʻaina. Mai nāʻauʻau wai.
Koho ʻia ka make o Krestor ma muli o ka pane o ka mālama ʻana a me ke kumu o ka hoʻohana ʻana i ka rosuvstatin, aʻo nā loiloi no nā pae lipoprotein i hoʻopaʻa ʻia. I ka wā o ka mālama ʻana me ka lāʻau lapaʻau, kuhikuhi ʻia ka mea maʻi i kahi lipid-hoʻemi haʻahaʻa (maʻamau) no ka hoʻohana mau ʻana.
I ka mea e hoʻololi i ka hoʻohana o nā HMG-CoA reductase a i ʻole no ka manawa koho mua o Krestor, ua hoʻomaka ʻia ke ʻano hoʻomaka ʻana o 5-10 mg / lā. Koho aku ka koho o ka ʻikepili i nā mea hōʻike i ka cholesterol kū hoʻokahi, ʻo ka loaʻa o nā hopena a me nā mea kūlohelohe no nā hoʻopiʻi e hiki mai ana mai ka ʻōnaehana cardiovascular. Me ka hopena ʻole, hiki iā ʻoe ke hoʻonui i ka hewa o Krestor ʻaʻole i hala ma mua o 21 mau lā ma hope o ka hoʻomaka ʻana o ka lawe i ka lāʻau (ʻo ka hopena ka hopena therapeutic kiʻekiʻe e kēia manawa). ʻO ka lawe ʻana iā Krestor ma kahi maʻa o 40 mg kumu e hoʻonui ai i ka hopena o ka hopena o ka lāʻau hoʻohālikelike i nā hōʻemi haʻahaʻa, no laila ke hoʻonui ʻia nei ka nui o ka make ʻana o Krestor i ka 40 mg / lā me ka nui loa o ka ulu ʻana o ka hoʻopiʻi cardiovascular (me ka poʻe maʻi me ka hypercholesterolemia familial) a me ka maʻi koʻikoʻi hypercholesterolemia. Ke lawe ʻia nei ka hoʻonui ʻana i ka dosage i 40 mg / lā inā ʻaʻole i loaʻa ka hopena i makemake ʻia o ka hoʻohana ʻana iā Crestor ma 20 mg / lā, ʻoiai ka mea maʻi ma lalo o ka mākaʻi olakino kokoke. Pono ka nānā pono ʻana i kēlā mea maʻi e like me nā lā mua o ka lawe ʻana iā Krestor ma ke ʻano o 40 mg / lā.
Hoʻomaopopo ka hoʻonui ʻana i ka pane ma ka hihia o ka hopena i makemake ʻia i ka wā e lawe ai i kahi kaila o 20 mg a ma lalo o ke kūlana e waiho ai nā maʻi ma lalo o ka mākaʻi loea o kahi loea. Hoʻokumu ʻia ka mana kūikawā ma ka hoʻomaka ʻana o ka lawe ʻana i 40 mg o ka lāʻau.
ʻO nā mea maʻi me kahi kiʻi geriatric, ʻaʻole ia e koi i ka hoʻoponopono hoʻoponopono ʻia.
Me ka pani ʻole ʻana
ʻO nā mea maʻi me ka haʻahaʻa haʻahaʻa ʻaʻole pono e hoʻoponopono hoʻoponopono lāʻau. No ka poʻe maʻi me ka hikiʻole o ka renal moderate, ʻo ka hoʻomaka hoʻomaka ʻana o ka rosuvastatin he 5 mg / lā.
ʻO ka nui o ka nui o kēlā me kēia lā no ka hiki ʻole o ke kīleʻa ʻoi aku ka 40 mg / lā, no ka hikiʻole o ka renal moderate (me ka level clearance creatinine ≤60 ml / min) - 20 mg / lā.
ʻO ke koho ʻana o Krestor i contraindicated ma nā maʻi me ka pilikia ʻole loa.
Me ka pohō hema ʻole
ʻAʻoheʻike i ka hoʻohana ʻana o Krestor i nā maʻi me ka maʻi hepatic i loiloi ʻia ma ka helu Childe-Pugh o 9 a keu paha. ʻO ka koho ʻana iā Krestor i nā maʻi maʻi me nā maʻi pēpē ma ka hana ikaika ua contraindicated.
Nā hui ʻano
ʻO ka hoʻonui pinepine loa o ka hoʻoulu ʻana o ka rosuvastatin i nānā ʻia i ka poʻe maʻi o ka lāhui Mongoloid. Pono e hoʻomaka i kēlā mau maʻi e hoʻomaka ai me ka maʻi ma kahi o 5 mg / lā, me ka nui o 20 mg / lā. ʻO ke koho ʻo Krestor no nā poʻe maʻi o ka lāhui Mongoloid ma kahi pānaʻi o 40 mg / lā ua contraindicated.
Me ka manaʻo e hoʻomohala i ka myopathy
I ka poʻe maʻi me ka hopohopo i ka loaʻa ʻana o ka myopathy, ʻo ka hoʻomaka hoʻomaka ʻana o ka rosuvastatin he 5 mg / lā, ka nui loa - 20 mg / lā. Ka koho ʻana o kahi mahele o Crestor ma 40 mg / lā i contraindicated ma ia mau mea maʻi.
Nā hopena hopena
ʻO ka maʻamau o nā hopena ʻokoʻa, e like me nā HMG-CoA reductase inhibitors, pili i ka maʻi i hoʻohana ʻia.
Ka loiloi o nā hopena ʻokoʻa i ka ʻike ʻia: nā hopena pili pinepine (≥1 / 100, ≤1 / 10), nā hopena ʻaoʻao hema (≥1 / 1000, ≤1 / 100), nā hopena ʻeha ʻokoʻa (≥1 / 10,000, ≤1 / 1000) nā hopena maikaʻi loa (≤1 / 10,000). ʻO nā hopena ʻaoʻao i ka wā e hoʻohana ai iā Krestor e helu ʻia e like me ka mau hoʻākāka ʻana a kau i kā lākou iho. ʻO ka pau ʻana o ka lapaʻau e Krestor i ka wā o nā hoʻokolohua lapaʻau ma muli o ka loaʻa mai o nā hopena hopena he 4% a emi ʻole paha.
Mai ka ʻōnaehana hoʻonāukiuki: dizziness, headache (pinepine).
Mai ka ʻaoʻao o ka ʻōnaehana pale: kūlike ka hopena (me ke angioedema) - loaʻa pinepine ʻole.
Ma ka ʻāpana o ka ʻili a me kāna mau hoʻohui: rashes, itching, urticaria (infrequent side effects).
Mai ka papa musculoskeletal: rhabdomyolysis a me myopathy (pilikia), ʻeha pū ka naʻau (pinepine). ʻO Myopathy, ʻehaʻeha, a me (rnmna) mau mea i loaʻa i ka rhabdomyolysis i ʻike ʻia i nā mea maʻi nā poʻe i lawe i kekahi maʻa o Crestor, akā ʻo ka mea i hoʻohana i ka nui o 20 mg / lā. ʻO ka hoʻonui ʻia ʻana o ka hopena i ka pae o ka phosphokinase (CPK), nānā i nā mea maʻi i lawe iā Krestor, ma ka hapanui o nā hihia ʻaʻole i hōʻike ʻia, transient a ʻaʻohe mau hōʻailona. I ka hihia o ka hoʻonui o ka mahele o ka CPK e 5 a i nā manawa hou aku, ua kau ʻia ka hoʻokomo o ka rosuvastatin.
Mai ka gastrointestinal tract: constipation, abdominal pain, nausea (pinepine), pancreatitis (jarang).
Mai ka urinary system: tubular proteinuria. Aia i ka hoʻololi o ka nui o ka protein i loko o ka mimi i ka helu ʻana mai ka haʻalele ʻana i ka hōʻea o ka protein a i ʻole ʻelua mau mea hou aʻe a i ʻole i loko o ka ≤1% o nā maʻi nā mea i kuhikuhi ʻia he lāʻau o Crestor 10-20 mg / lā. Ke lawe nei i kahi maʻa o 40 mg / lā, ʻo ka nui o nā mea maʻi e like me ka 3% o nā maʻi. Ke hoʻohana nei i kahi nui o Krestor o 20 mg / lā, ua ʻike ʻia ka liʻiliʻi o ka nui o ka protein i loko o ka urine. ʻO ka Proteinuria i ka hapa nui he mau hoʻoneʻe a nalowale paha me ka hoʻohana mau ʻana a ʻaʻole ia he hōʻailona o ka hoʻomohala ʻana i ka maʻi ʻōpili a ʻo ka holomua ʻana o kahi mea e noho nei.
Mai ka puʻuwai: i kahi helu liʻiliʻi o nā mea maʻi, ua ʻike ʻia kahi hoʻonui ʻana o ka maʻi o ka transaminases, e like me nā HMG-CoA reductase inhibitors. ʻO ka hoʻonui ʻana o nā transaminases i ka hapa nui o ka hihia, he transient, me ka ʻole o nā hōʻailona a me ka liʻiliʻi.
ʻO kekahi: asthenia (pinepine).
Ma hope o ka hoʻomakeha nui ʻana o Krestor i ka hana lapaʻau, ua hōʻike pū ʻia nā hopena aʻe nei:
Mai ka pūnaehana musculoskeletal: ʻeha puʻuwai (ʻāʻuhi).
Mai ka pūnaehana nūhou: polyneuropathy (loaʻa pinepine).
Mai ka ʻōnaehana hepatobiliary: hepatitis a me nā jaundice (loaʻa pinepine loa).

Nā Hoʻohui
· Nā maʻi maʻi ma ke ʻano ikaika, me ka hoʻomau mau ʻana i ka pae o ka transaminases o ka ʻike ʻole ʻia, a me kahi hoʻonui i nā transaminases me kahi pae he 3 mau manawa a ʻoi aku paha ua kiʻekiʻe aʻe ma mua o ka palena palena o ke kumu maʻamau.
Hōʻeha hōʻeha o ka renal i ka hana hōʻino ma kahi o ≤30 ml / min,
ʻO ka hoʻohana ʻana i ka cyclosporine,
I ka wā hāpai a me ka lactation,
Hypersensitivity o ka ʻōnaehana pale i rosuvastatin a i ʻole kekahi mea ʻē aʻe o Crestor,
· ʻAʻole i kuhikuhi ʻia ka lāʻau lapaʻau i nā poʻe maʻi e hoʻohana ʻole nei i nā hana kūpono a me ka hopena o ka contraception.
Myopathy
· Ka dosis o Crestor ma 40 mg / lā ua contraindicated i ka poʻe maʻi me ka nui o ka nui o ka rhabdomyolysis a i ʻole myopathy,
· Makahiki ma 18 makahiki.

Kahawai
Hoʻopili ʻia ke keʻa no ka hoʻohana ʻana i nā wahine hāpai. Ma ka hihia o kahi e koho ai i kahi makuahine hānai, ua pau ka hana umauma. Ma mua o ka mālama ʻana me Krestor i nā wahine o ka wā o ka hānau ʻana, pono ia e hoʻokau i ka hoʻohālikelike ʻana. ʻOiai e lawe ana i ka lāʻau lapaʻau, pono ia e hoʻohana i nā ala kūpono o ka contraception.

Hoʻohui nūhou
Me ka hoʻohana like ʻana o ka cyclosporine a me rosuvastatin, ʻo AUC o ka mea hope loa he 7 mau manawa nui ma mua o ke ana hoʻohālike i nā paakiki olakino. ʻO ka hoʻohana like ʻana o kēia mau lāʻau, ʻaʻole e loli i ka neʻe ʻana o ka plasma o ka cyclosporine.
I ka hoʻomaka ʻana o ka hoʻōla a ma ka manawa o ka hoʻonui ʻana i ka dosis Crestor, nā maʻi e loaʻa ana i nā warfarin a me nā ʻano ʻē aʻe vitamin K Kagon i ka manawa like, e like me nā HMG-Co-A reductase inhibitors, hiki ke loaʻa i ka hoʻonui i loko o INR - International Normalized Ratio - prothrombin manawa. ʻO ka hoʻopauʻana i Krestor a i hōʻemi paha i kāna kauʻana ke kumu e hōʻemi ai i INR. Ke hoʻohui nei i ka Crestor me ka vitamin K antagonist, nānā ʻia ka nānā ʻana o INR (prothrombin manawa).
ʻO ka hoʻohana like ʻana o nā lāʻau lipid-hoʻohaʻahaʻa (no ka laʻana, hemifibrozil) a me ka rosuvastatin e hoʻonui i ka plasma kiʻekiʻe o ka rosuvastatin a hoʻonui i kona AUC ma o 2 mau manawa.
ʻO ka hoʻohana like ʻana o ka ezetimibe lāua ʻo Krestor ʻaʻole i kumu i nā loli i ka nui o ka plasma wela o nā lāʻau ʻelua, a me AUC hoʻi. Eia naʻe, ʻaʻole ia e manaʻo e haʻalele i kā lākou lāʻau lapaʻau lāʻau me ka hoʻomohala ʻana i nā hopena ʻaoʻao.
ʻAʻole iki ʻia kahi pilina pharmacokinetic me nā fibrates, akā hiki i ka pharmacodynamics ke hoʻopili. Hemofibrates, gemfibrozil, nā fibrates a me nā lipid-hoʻohaʻahaʻa i ka momona o ka acid nikotinic (ma kahi kikoʻī e like me ka 1 g / lā a i ʻole ka hapa) i ka hopena o ka hoʻomohala ʻana i ka myopathy aʻo ka lawe ʻana me ka HMG-CoA reductase inhibitors. ʻO kēia paha no ka mālamaʻana i kēia mau mea i ka hoʻomaka ʻana o ka myopathy i ka wā i kuhikuhi ʻia ai lākou he monotherapy. No laila, me kēia hui pū ʻana, ʻo ia ka mea e hōʻike i nā mea maʻi i kuhikuhi mua i kahi maʻa o Krestor 5 mg / lā.
Ma kahi hoʻokolohua pharmacokinetic i nā mea hana olakino olakino, ka hui pū ʻana o Crestor a me ka hui pū ʻana me ʻelua o nā mea i hoʻopaʻa ʻia ʻo protease (100 mg ritonavor a me 400 mg lopinavir) i pili me ka piʻi ʻana o 2 mau pā i AUC no Crestor. I kēia hihia, hoʻonui ʻia ka nui o ka rosuvastatin e pili ana i ka 5 mau manawa. ʻAʻole i aʻo ʻia nā pilina me nā poʻe protease hou. Ke kuhikuhi nei iā Krestor i ka poʻe maʻi maʻi maʻi HIV e lawe ana i ka ritonavir / lopinavir aʻo ke hoʻohana ʻana iā Krestor, pono ke noʻonoʻo pono ka pae pilikia / pōmaikaʻi, ʻo ia ke ʻano nui o ka hoʻonui ʻana i ka nui a i ka hoʻomaka ʻana o ka mālama ʻana.
ʻO ka hoʻokolohua i ka manawa erythromycin a me rosuvastatin e hōʻemi ana i ka AUC o ka rosuvastatin ma ka 20% a me ka pae ʻai kiʻekiʻe o ka plasma he 30%.
ʻAʻole i aʻo ʻia ka maʻi koʻikoʻi o ka pilina o nā antacids a me Krestor. ʻO ka hoʻohana like ʻana o nā antacids me ka hoʻopili ʻana i ka pūnaehana o ka hynesxide magnesium a i ʻole alumini a me ka rosuvastatin e hōʻemi ai i ka hoʻoliʻelana ʻana o ka mea o ka hopena i loko o ke koko plasma e 50%. Inā lawe ʻia nā antacids i 2 mau hola ma hope o rosuvastatin, a laila ʻaʻole ʻōlelo iki ka hopena.
No ke kūkākūkā nui ʻana me kahi digoxin i manaʻo ʻia.
ʻO ka hoʻohana like ʻana o rosuvastatin a me nā ʻōlelo laha e hoʻonui ai i ka AUC o norgestrel a me ka AUC o ka ethinyl estradiol ma kahi o 34% a 26%, kekahi. No laila, pono e noʻonoʻo pono i ka piʻi ʻana o ka neʻe ʻana o ka mea lawe i ka wā e lawe ai i nā mea hoʻohālikelike.ʻAʻole i aʻo ʻia nā ʻano pharmacokinetic ma ka hui ʻana o Krestor a me nā lāʻau lapaʻau no ka lāʻau hoʻokolohua hormone. Ua hoʻohana nui ʻia ka like me nā lāʻau lapaʻau i ka wā o nā hoʻokolohua maʻi.
ʻO nā hualoaʻa o kahi hōʻike ma ka hoʻopaʻa ʻana o ka vivo a me ka in vitro e hōʻike ana i ka hana ikaika o Krestor ʻaʻole he inducer a ʻaʻole hoʻi he mea pale o nā enzyme o ka pūnana cytochrome P450. ʻO Rosuvastatin kahi papa lepo wale nō no ka hana o kēia mau hana. ʻAʻohe hui koʻikoʻi maʻi ma waena o ketoconazole (kahi mea paʻa o CYP 3A4 a me CY P 2A6) a i ʻole fluconazole (kahi mea paʻa o CYP 3A4 a me CYP 2A9) a me rosuvastatin. ʻO ka mākaukau o ka itraconazole (kahi CY P3A4 inhibitor) a me ka rosuvastatin e hoʻonui ai i ka AUC o nā mea hope loa ma ka 28%, ʻaʻohe ʻano kīnā. No laila, ʻaʻole i manaʻo ʻia nā mea pili i hoʻopili ʻia me ka metabolism o ka cytochrome P450.

Ke keu
Inā nui aʻe ke ʻano, ʻaʻole i kūkulu ʻia ka mālama kūikawā. Hoʻohana ka poʻe maʻi symptomatic a me ke kākoʻo kākoʻo. Inā nui aʻe ka nui o ka make, pono ia e kāohi i nā hana o ka ate a me nā kiko o nā creatine phosphoskinase (CPK). ʻAʻole like ka maikaʻi o ka hemodialysis.

E hoʻokuʻu i ke ʻano
Nā Papa o 10, 20, 40 mg. He 28 mau papa i loko o kahi puhipuhi.

Nā kūlana mālama
Store ma kahi wela ʻaʻole oi 30 ° C. Mai mālama i nā keiki. Hoʻokuʻu ʻia e ka papa lāʻau.

Hōʻike
Koko 10 mg
ʻO kēia papa hana: rosuvastatin 10 mg.

Kahu 20 mg
ʻO kēia papa hana: rosuvastatin 20 mg.
Nā mea waiwai: lactose monohala, microcrystalline cellulose, calcium phosphate, magnesium stearate, crospovidone, glycerol triacetate, hypromellose, iron oxide red (E 172), titanium dioxide, wai maʻemaʻe.

Kapaha 40 mg
ʻO ka papa hana: rosuvastatin 40 mg.
Nā mea waiwai: lactose monohala, microcrystalline cellulose, calcium phosphate, magnesium stearate, crospovidone, glycerol triacetate, hypromellose, iron oxide red (E 172), titanium dioxide, wai maʻemaʻe.

ʻĀpana Pharmacological
Ke lāʻau lapaʻau Cardiovascular
ʻO ka lāʻau antisclerotic

Mea waiwai: Rosuvastatin

Kālai koho
Me ka hoʻonui nui o ka hoʻomohala ʻana i ka myopathy a i ʻole rhabdomyolysis, pono ia e noʻonoʻo i ka hoʻohālikelike o ka loaʻa o o nā hōʻola a me nā hopena o ka hopena, hiki i nā mea maʻi ke mālama i ka mālama mālama maʻi. Ma ka hanana e piʻi nui ka pae o ka CPK (5 mau manawa a ʻoi paha) ma mua o ka hoʻōla ʻana, ʻaʻole pono ka lāʻau rosuvastatin. ʻO ka manaʻo o ka crococulinase cretin e kāohi i ka hoʻomohala hiki i ka rhabdomyolysis a i ʻole myopathy he kūpono ʻole e lawe i mua o nā pilikia ʻē aʻe no ka hoʻonui i CPK a ma hope o ka hoʻoikaika kino kino loa, no ka mea hiki i kēia ke hana i kahi unuhi pololei o nā hopena. Inā hoʻonui ʻia nā ʻike mua o ka phosphokinase 5 mau manawa a keu paha, pono e hoʻoholo ʻia ka hopena hou o ka enzyme i loko o ka serum koko ma mua o 5 (lōʻihi - 7) mau lā. ʻAʻole ʻoe e hoʻomaka ma ka mālama ʻana me Crestor inā hōʻike ka lua hopena i kahi kiʻekiʻe mua o ka phosphokinase kiʻekiʻe (5 mau manawa hou aʻe ma mua o ka palena o ka maʻamau).
Pono Crestor, e like me nā HMG-CoA reductase inhibitors, pono ke kauoha me ka makaʻala i nā poʻe maʻi me ka manaʻo e hoʻomohala i ka myopathy / rhabdomyolysis. Hiki i nā mea pilikia no ka rhabdomyolysis a i kaʻu myopathy: hypothyroidism, renal failed, nā kūlana e hoʻonui ai i ka plasma kukuna o ka rosuvastatin, ka hōʻino ʻona ma mua o 70 mau makahiki, ka hiki ʻana o nā maʻi mōʻī o ka hoʻoilina i kahi ʻohana a pilikino paha, ua hoʻoneʻe ʻia ka myotoxicity e ka hoʻohana ʻana o nā fibrates a i ʻole MMC-inhibitors. ʻO ka mōʻaukala o CoA reductase, hoʻohana paʻa o nā fibrates.
Inā hoʻonoho ʻia ʻo Krestor i kahi maʻi, e koi ʻia lākou e hōʻike iā ia i kahi kauoha e pili koke ana i ke kauka hele e pili ana i nā pilikia āpau o ka nāwaliwali o ka naʻau, ʻehaʻeha a ʻehaʻeha paha, inā ua hele pū lākou me ka maʻi a me ka malaise. I ia mau mea maʻi, pono i kahi hoʻoholo o ka pae o ka creatok phosphokinase (CPK). Pono e ʻae ʻia ʻo Krestor inā he hoʻonui nui ʻia nā kiko o ka CPK (5 mau manawa a i ʻole), a i ʻole a me ka ʻīhī koʻikoʻi o nā hōʻailona ʻeha e hōʻeha mau i kēlā me kēia lā a hiki i ka ʻike o nā creatine phosphokinase ʻaʻole e hōʻea i ka hoʻonui ʻana 5-pā. Inā nalowale nā ​​hōʻailona a hoʻi i ka hoʻonaninani CPK i kāna kumu pilikino physiological, e noʻonoʻo e hiki ke kiʻi hou i nā HMG-CoA reductase a i ʻole Crestor inhibitors i nā haʻahaʻa ma mua o nā mea i hala aʻe. Pono kēlā ʻano maʻi e nānā kiaʻi. ʻO ka mālama pono ʻana i ka CPK i ka loaʻa ʻole o nā hōʻailona o ka rhabdomyolysis a i ʻole myopathy he hoʻomaʻamaʻa ʻole.
ʻAʻohe hōʻailona i ka piʻi ʻana o ka mana o Crestor i ka ʻōpū mākala i ka wā o nā hoʻokolohua me nā maʻi concomitant. Eia nō naʻe, aia kahi lono o ka hoʻonui i ka hiki ʻana o ka myopathy a me myositis i nā poʻe maʻi i lawe i nā poʻe HMG-CoA reductase inhibitors me nā derivatives acid fibrin (me ka hoʻohana ʻana i nā lāʻau lapaʻau e like me ka nicotinic acid, gemfibrozil, cyclosporine, inhibitors protease, azole antifungal drug a me macrolide antibiotics). Hoʻonui ka Gemfibrozil i ka hopena o ka hoʻomohala i ka myopathy me ka hui pū o Crestor me kekahi mau HMG-CoA reductase inhibitors. ʻAʻole ia e kuhikuhi i kuhikuhi i Krestor a me gemfibrozil i ka manawa like. Pono e loiloi maikaʻi i ka māhele o nā pōmaikaʻi o nā pono a me nā hopena e kū pono ana i ke koho ʻana i kahi hui o niacin, fibrates a me Crestor.
ʻO ka hoʻokele hui me Krestor fibrates i loko o kahi pākuʻi o 40 mg ua contraindicated.
ʻAʻole i kau ʻia ʻo Krestor no nā maʻi me nā maʻi koʻikoʻi nui (no ka laʻana, me ka hypotension arterial, trauma, sepsis, i ka wā o ka hōʻiliʻili o ka hoʻomaʻamaʻa, i ʻōlelo ʻia ka endocrine, ka metabolic a me ka electrolyte luhi, a me ka hihia o ka epilepsy i kāohi ʻole ʻia, no ka mea, hiki i kēia mau maʻi ke lilo i hopena kumu no ka rhabdomyolysis / myopathy).
I ka poʻe maʻi e lawe i ka rosuvastatin i nā kiʻekiʻena nui (ʻo ka hapanui ma kahi o ka 40 mg / lā), aia kahi mau o ka proteinuria tubular. ʻO ka palupalu tubular proteinuria i ka pōkole a i ʻole transient i ka hapa nui. ʻAʻole kēia proteinuria hōʻike hōʻike i ka hoʻomohala ʻana i ka maʻi paleka o ka maʻi a i ʻole ka holomua o kahi mea e noho nei. ʻO ka poʻe maʻi e loaʻa iā Krestor ma loko o kahiʻu o 40 mg / lā, ua manaʻo ʻia e nānā i nā manawa maʻamau i nā hana maʻamau o nā keiki i ka wā o ka hoʻokipa ʻana o Krestor (ka papa holoʻokoʻa o ka hopena).
Ke lawe nei i ka rosuvastatin, inā paha ma nā inika e pili ana i ka 20 mg / lā, ua loaʻa nā lono o nā hopena mai nā ʻālae māla, e like me ka ʻeha o ka naʻau, rhabdomyolysis, a me ka myopathy. Eia nō naʻe, me ka hui pū ʻana o nā ezetimibe a me HMG-CoA reductase inhibitors, rhabdomyolysis i kūkulu ʻia i nā hihia loaʻa ʻole loa.
ʻAʻole paʻa i ka palekana a me ka hana o ka hoʻohana ʻana o Krestor i nā keiki. I ka hana maʻi keiki, ua palena ʻia ka ʻike o ka hoʻohana ʻana i rosulostatin i kahi helu liʻiliʻi o nā mākaʻi (nā keiki ma lalo o 8 mau makahiki a ʻoi aku paha i mua o ka homozygous hypercholesterolemia famoial. No laila, ʻaʻole i kuhikuhi ʻia e hoʻohana Krestor no ka mālama ʻana i ka hana maʻi pediatric.

Hōʻike ʻia nā ʻikepili āpau no ka ʻike ʻike a ʻaʻole ia he kumu no ka hoʻonohonoho ponoʻī ʻana a me ke koho ʻana i kahi lāʻau lapaʻau.

Hiki iā ʻoe ke lilo i ka palaka o ke ola maʻamau, a ma hope o ke ʻano loiloi, e aʻo e pili ana i ka hyperlipidemia - he nui ka nui o ka kolamu a me nā triglycerides i ke koko.Hoʻonui koʻikoʻi ka maʻi Asymptomatic i ka hopena o ka plaher atherosclerotic - nā mea ākea o ka puʻuwai naʻau a me nā hōʻeha.

ʻO Krestor, kahi lāʻau lapaʻau hope loa i hoʻolālā ʻia e hoʻoponopono hou i nā metabolid lipid, e kōkua i ka pale aku i nā hopena pōʻino.

Hiki i nā pono Pharmacological

ʻO Crestor kahi lāʻau lapaʻau lipid i hoʻolālā ʻia no ka pale ʻana a me ka mālama ʻana i ka atherosclerosis. ʻO Rosuvastatin, ka papa hana koʻikoʻi, loaʻa nā hopena hypocholesterolemia a me ka lipid-lowing.

Hoʻopiliʻo Krestor i ka hoʻoneʻe ʻana o HMG-CoA, kahi enzyme e mālama i ka hana o mevalonate, kahi mua kolesterol. E hana ana ʻo Rosuvastatin i ka puʻu - kekahi o nā papa nui.

Ua hōʻemi ʻo Statin i ka nui o nā lipoproteins me ka haʻahaʻa haʻahaʻa a me ka haʻahaʻa e ke kāohi ʻana i ko lākou synthesis, me ka ulu ʻana o ka HDL i ka hoʻohui a me ka catabolism LDL. ʻO ka hopena, ua hoʻemi ka nui o ka kolamu o ka kolamu, LDL a me ka triglycerides. Ma ka manawa like, hoʻonui ka hoʻoili o HDL.

Pono ʻo Rosuvastatin no hypercholesterolemia i hui pū ʻia a ʻole ʻole he hypertriglyceridemia, no nā mea maʻi o kekahi ʻano kāne, ʻano a me nā lāhui.

ʻO ka hopena o ka hoʻohana ʻana o Krestor, ka hoʻopaʻi ʻia e ka pane mai nā poʻe noiʻi, ʻike ʻia e ka hopena o ka pule mua o ka papa, akā ʻike ʻia ka hopena kiʻekiʻe (ma o 90%) ma hope o he mau hebedoma 2-4 o ka hoʻohana maʻamau.

ʻAʻole i like kekahi o nā mea kikoʻī, ʻo Krestor kahi liʻiliʻi o nā hopena maikaʻiʻole o ka ate. Hoʻohana ia ia me ka hui pū me ka lāʻau haʻahaʻa haʻahaʻa a me nā lāʻau ʻē aʻe e hoʻohaʻahaʻa i ka cholesterol.

He aha nā mea a nā kauka a me nā mea maʻi e noʻonoʻo ai no Crestor

E pili ana iā Krestor, pili pū nā loiloi o nā kauka a me nā mea maʻi: ikaika ka lāʻau lapaʻau, ʻae ʻia. Kuhi nui nā kauka i kahi waihona hōʻike ʻoi nui a me ka ʻike pilikino o ka hoʻohana pono ʻana o ka rosuvastatin.

Dovgopolov I.K., cardiologist, poʻomanaʻo o nāʻike lapaʻau No hoʻokahi mahina a ʻelua paha, ʻaʻole wau i kakau iā Krestor a me kāna mea i hoʻohālikelike ʻia, ʻo ia hoʻi no ka pale ʻana. Hiki iā ʻoe ke hoʻomaʻemaʻe maoli i nā kīʻaha a hoʻokuʻu iā lākou mai nā palaki kolala ma nā makahiki ʻelua, a ʻo kēia ma ka dosis nui (40 mg / lā).
Inā hāʻawi ka kālā, ʻoi aku ka maikaʻi e kūʻai i ka lāʻau lapaʻau mua. ʻO ka pepa kumu mua o ka rosuvastatin ʻo Krestor, nona ka hoʻokolohua ʻana i hoʻokele ʻia me kahi helu helu maʻi mai nā maʻi ʻeha. No nā ulu kuaha, ʻaʻohe ʻikepili o nā palapala, akā i koi ʻia ka mea hoʻokūkū o ka mea pono e hoʻomaikaʻi i ka profile lipid, akā naʻe, ʻaʻole ia me ka maikaʻi loa. Pono e ʻōlelo aku ʻaʻole lawe ʻia nā statins e hoʻohaʻahaʻa i ka LDL, akā e pale ai i nā hōʻeha a me nā ʻeha puʻuwai. Pono e lawe ʻia nā lāʻau lapaʻau lōʻihi e hoʻomau.

Korolenko V.N., neurologist. Ua hoʻihoʻi wikiwiki ʻo Krestor i ka hana lipid metabolism a ma o nā helu haʻahaʻa. He paʻa ka kumu hōʻike o ka lāʻau kūlohelohe, aia ka liʻiliʻi o nā hopena ʻokoʻa ma mua o nā statins ʻē, no laila hiki iaʻu ke kuhikuhi maluhia iā ia i nā poʻe maʻi me nā maʻi concomitant e like me ka diabetes mellitus a i ʻole ka hypercholesterolemia familial. ʻO ke kumukūʻai no Krestor, ʻoiaʻiʻo, he mea kupaianaha nō ia, akā, ʻo ia wale nō ka hapa hemahema, ʻoiai ʻoiai, ʻaʻole hiki i ka lāʻau lapaʻau ke kiʻekiʻe.

Marina, Voskresensk. Krestor i kekahi mau manawa i ʻoi aku nā kumukūʻai ma mua o kona mau hoaaloha, i mea e mālama ai i ke kālā ʻaʻole wau e kūʻai i kahi pūʻulu nui, akā noʻu iho ʻaʻole wau i ʻike i kahi mea hou aʻe. Ua lawe wau i statin no hoʻokahi makahiki a ʻoi aʻe, no laila ua hiki iaʻu ke hoʻoponopono i kona pono. Pōmaikaʻi nā kauka i kaʻu kiʻi lipid. Manaʻo ʻo ia ʻo Krestor ka lāʻau lapaʻau maikaʻi loa o kēia pūʻulu. ʻAʻole nānā wau i nā hopena ʻaoʻao.

Oleg, Irkutsk. Hoʻokomo ʻia kaʻu puʻuwai puʻuwai me aʻu e kahaha a noʻonoʻo iaʻu i koʻu olakino. Hele i ka haleahi, e ʻimi ana e haʻalele i ka uahi. Ua kuhikuhi i ke kauka i kahi meaʻai a me Crestor. ʻAe inu wale nō wau i ʻelua malama, ʻaʻole wau ʻike - mai nā lāʻau aiʻole nā ​​pahu e aʻo ai me kahi mea hoʻomaʻamaʻa, akā hiki ke maʻamau ka kolestia i kēia manawa - 5.8. ʻAʻole wau makemake e hilinaʻi i nā lāʻau lapaʻau i koʻu ola a pau, no laila ke ho'āʻo nei wau e mālama i kahi ala hou noʻu.

Hiki iā ʻoe ke aʻo e pili ana i ka ʻike ʻAmelika e hoʻohana ana iā Krestor mai ka wikiō “ʻo nā lāʻau lapaʻau no nā kānaka olakino”.

ʻO ke kumu o ka lāʻau lapaʻau Krestor, ka mea i hōʻike nui ʻia e nā konohue i loko o ka pūnaewele apotekini, pono ia e hoʻohaʻahaʻa i ka cholesterol koko. E ʻike ʻia ka hopena therapeutic ma hope o 7 mau lā mai ka hoʻomaka ʻana o ka hoʻokele ʻana. I nā hebedoma e hiki mai ana, ʻoi aku ka 2 o ka lāleʻa i hōʻemi ʻia o ka cholesterol kino. Ma muli o nā kūlana like ʻole, hiki ʻole ke hoʻohana mau ʻia ka lāʻau lapaʻau maoli, i kēia hihia, ua hoʻohana ʻia kahi ʻano generic (analog).

ʻO kahi pūʻali nui o nā mea lapaʻau

Ma mua o ka kuhikuhi ʻana i kekahi lāʻau lapaʻau, pono ʻoe e hana i kahi hoʻokolokolo. ʻO kāna kumu e hoʻoholo i ke kiʻekiʻe o ka noʻonoʻo o ke kino. Inā kū mai kahi kūpono kūpono, hiki i kekahi o kēia mau lāʻau lapaʻau ke hiki ke hoʻololi i ka huahana mua:

Loaʻa i ka mea maʻi ka koho i nā analogue haʻahaʻa ʻaʻole ia i haʻahaʻa ma kā lākou mau hōʻailona i ka lāʻau lapaʻau nui. Pono e hoʻomanaʻo ʻia o ka dosage a me ka lōʻihi o ka hoʻohana ʻana e kau ʻia e ka kauka wale nō ma ke kumu ʻike i hiki ai ke ʻike. Hoʻopili kēia mau mea i ka pale a me ka mālama ʻana i ka atherosclerosis a me ke kolamu kiʻekiʻe.

ʻO kahi koho i koho ʻia me ke kūloko kūpono e kōkua i ka hopena maikaʻi. Pono ke kauka e hoʻoholo i ka nui o ka lāʻau i ka mālama pono ʻia i ka wā i loaʻa ai i ka mea maʻi i kahi hōʻeha a i ʻole hōʻeha ka naʻau. Inā hōʻike kekahi e ka maʻi iā hypercholesterolemia - ua hoʻololi ʻia ka pathologically i loko o ke koko, pono ia e hoʻohana i nā lāʻau lapaʻau paʻakikī.

Hoʻomaʻamaʻa pinepine ʻia ka lāʻau kanu kumu mua a me kāna mau mea hoʻohālikelike e like me kahi ma ka ʻai. ʻO ka laʻana, ʻōlelo ka kauka i ka hoʻemi ʻana o ke kaumaha kino kino. I kēia hihia, hiki iā ʻoe ke hoʻohana i ka hoa Lūkia. Ke kamaʻilio nei mākou e pili ana i ka lāʻau lapaʻau Martinil, Ariescor a me Simvastin. Kūpono ʻia kahi ʻōlelo like ʻole i ka wā e loaʻa ana ka mea maʻi i kahi ʻano maʻi maʻi mua.

Koho ʻia ka nui o ka dosage no laila ʻaʻole e hoʻonāukiuki i ka cholesterol nā hopena hopena.

Nā hiʻohiʻona o ka hoʻohana ʻana i ka lāʻau

ʻO nā maʻi o ka ʻā a me nā ʻōpala nā mea nui e pono ai ke noʻonoʻo ʻia e wikiwiki ai ke kaʻina ho'ōla. Ma muli o nā kumu i nā mea i hoʻohālikelike ʻia nā mea e pili ana i nā keena o ka hematopoietic organ, pono ke kauka ke kauka i ka hopena i kekahi mau manawa. Ma ka lima, pono e hoʻokaʻawale i ka hana o nā kīʻaha koko i ka hiki koke o ka hiki. ʻOi aku ka lōʻihi o ka hoʻoilo ʻia ʻana o ka polikoli, me ka ʻoi aku ka paʻakikī o ka hele ʻana o ke koko i ka holo ʻana o ke kino.

Ma ka ʻaoʻao ʻē aʻe, pono e noʻonoʻo ʻoe i ka dinamics o ka mokiki. Inā nānā ʻia ka pale ʻana o kēia kaʻina hana, ua noi ʻia e koho i ke ʻano liʻiliʻi no ka ʻae ʻokoʻa - ʻaʻole iʻoi aku ma mua o 25 g o nā mea i ka lā. Ke kauka nei ke kauka ma ke ʻano o ka lāʻau lapaʻau i ke olakino o ka mea maʻi. Pono ke kiaʻala e like me ka loaʻa ʻana o ka mea maʻi i ka palaki ʻana i nā keiki.

E kōkua ka hoʻomaʻamaʻa mua i ka hana ʻole e hōʻino. Wahi a nā hopena i loaʻa, ua huki ʻia kahi hopena i ka hiki ke hoʻohana i ka lāʻau. Ma waena o nā meaʻokoʻa'ē aʻe, e hoʻokaʻawale nā ​​kauka i ka makahiki o ka mea maʻi, ka hiki ʻana o nā maʻi maʻi, ma mua o nā lāʻau lapaʻau i kuhikuhi ʻia a me ka nui o nā hiʻohiʻona pilikino.

Pākuʻi ʻana

Ma mua o ka hoʻomaka ʻana i kahi papa therapeutic, pono pono ke kauka ke nānā inā palekana a i ʻole nā ​​huahana kumu mua no ka mea maʻi maʻi. ʻAʻole ia e hāʻawi i koho ʻia i nā makuahine a me nā lactating. ʻOi aku ka maikaʻi ma ke koho ʻana i nā mea hou aku o Krestor me ka hypersensitivity, ka hana a ka ʻekaʻeha o ke akea, inā ka mea ma lalo o ka 18 makahiki.

ʻO ka hoʻohana ʻana i ka analog a i ʻole ka lāʻau nui me ka kolamu ʻaʻole e palekana mau. ʻOiai inā nānā ke kauka i nā mea āpau āpau, hiki ke ʻae i nā hopena kūpono:

• ke hiʻohiʻona o ka maʻi maʻi
• migraine a me na poai
• pōʻai ʻino
• ka ʻeha ʻeha o ka ʻōpū
• nā ninia
• constipation
• āhāhuʻe
• urticaria
• ʻohiʻe a me ka ʻeha
• ʻaʻano pōkole.

Hoʻohana ʻia ka hoʻohana ʻana o ka lāʻau lapaʻau nui a me nā mea i hoʻopili ai ma hope o ke kipa ʻana i ke keʻena o ke kauka. Na ke kauka e hoʻokolokolo a kuhikuhi i nā hoʻokolohua kūpono. Ma muli o ka ʻikepili i hōʻiliʻili ʻia, ua ʻike ʻia kahi loiloi olakino. Ma hope o kēia, ua hoʻoholo ka hopena o ka therapeutic a me ka lōʻihi o ka hoʻokele. ʻO ka pololei e hoʻokō nei i ka mea maʻi i nā loiloi, ʻo ka wikiwiki ka hoʻihoʻi.