ʻO Maninil a me kāna mau kikowaena Hypoglycemic drug
NA ININA E hoʻokuʻu i ke ʻano Hōʻike ʻOhiʻohi Ka hana lāʻau lapaʻau Lapaʻau lāʻau Maninil, hōʻike hōʻailona no ka hoʻohana ʻana Nā Hoʻohui ʻLoe a me ke kākele ʻŌpū a me ka lactation Nā hopena hopena Nā ʻōlelo kikoʻī Hoʻokomo i ka hiki ke lawe i nā kaʻa a me nā mīkini ʻē aʻe e koi ai i ka nui o ka makaʻala Hoʻohui nūhou Ke keu Nā kūlana mālama ʻO ka lā kau Hoʻokumu ʻia e ka mea hoʻoponopono o nā metabolism glucose, ʻo Manin, i ka wā hoʻōla, hoʻonui i ka ʻike o ka insulin-receptors, hoʻoulu i ka hoʻokuʻu i ka insulin endogenous e ka pancreas. Eia kekahi, ke kāohi nei i ka gluconeogenesis hepatic a me ka glycogenolysis, mālama i ka lipolysis glucose, a e hōʻemi ana i ka thrombogenicity koko. ʻO ka lōʻihi o ka hopena hypoglycemic i hana ʻia e ka lāʻau lapaʻau ma 2 mau hola ma hope o ka 12 hola he 12 hola. Nā Papa Helu Glibenclamide Maninyl 3.5 mg ʻO ka māhele hoʻolaʻa haʻahaʻa o Maninil - glibenclamide, i hōʻike ʻia ma ke ʻano micronized, he hopena ʻulaʻuwale maikaʻi, hoʻopili koke ʻia i loko o ka ʻōpū ma ka 48-84%. Ma hope o ka lawe ʻana i ka lāʻau lapaʻau, hoʻopau loa ka glibenclamide i loko o 5 mau minuke. ʻO ka papa hana ikaika i hōʻiliʻili ʻia i ka palā a me ka hoʻopili ʻia e nā ʻōpū a me ka bile. Hoʻohana ʻia ka lāʻau lapaʻau i ka papa hana me nā ʻano like ʻole o ka mea hana 1 papa. Pale nā ʻōlapa ʻana me ka cylindrical ma ke ʻano, me kahi chamfer a hōʻailona ʻia i pili i kekahi o nā mea heʻe, he ʻulaʻulaʻula. ʻO ka mea hana o ka lāʻau lapaʻau ʻo FC Berlin-Chemie; i loko o nā kīkena i hoʻokaʻawale wale ʻia ia e ke kumu lāʻau. Hoʻopaʻa ka lāʻau i nā hue wai o ka pulu māmā, 120 pcs o kēlā me kēia. ma kēlā me kēia, hoʻopili ʻia nā hue iā lākou iho i kahi pahu pepa. ʻO nā ʻatikala Latin no Maninil e like me kēia: Maninil. Wahi a nā haʻawina, ʻo ka hoʻopili ʻana i ke ʻano kūpono i ka wā e lawe ai i ka lāʻau lapaʻau no ka hoʻēmi ʻana i ka hopena o ka hoʻomohala ʻana i ke ʻano o ka maʻi cardiovascular a me nā pilikia ʻē aʻe i hoʻonāukiuki ʻia e ka maʻi maʻi ole o ka insulin, me ka make me ka pili ʻana i kēia maʻi. ʻO ka papa inoa ma luna o nā mea hoʻohālikelike lapaʻau, e hōʻike ana Hoʻololi ʻo Maninil, kūpono loa ia no ka mea ua like lākou me ka like o nā mea hana a me ke kūleʻa e like me ke kuhikuhi ʻana no ka hoʻohana No ka ʻike ʻana i kahi analogue kūʻai like ʻole i ka lāʻau lapaʻau, kahi generic a i ʻole synonymation, ʻo ka mea mua mua mākou i manaʻo no ka hoʻolohe ʻana i ka hoʻopili ʻana, ʻo ia nā ʻano like ʻole o nā mea kaha a me nā hōʻailona no ka hoʻohana. Hōʻike ka mea like ʻole o ka lāʻau lapaʻau me ka lapaʻau a like pū me ka lāʻau lapaʻau, kūloko a me ka mea pono i ʻole nā lāʻau lapaʻau. Eia naʻe, mai poina e pili ana i nā māhele like ʻole o nā lāʻau like like, hiki ke pili i ka palekana a me ka hana. Mai poina e pili ana i nā kauoha a nā kauka, hiki i ka lāʻau lapaʻau ponoʻī ke hōʻeha i kou olakino, no laila e ʻōlelo mau i kāu kauka ma mua o ka hoʻohana ʻana i kekahi lāʻau lapaʻau. Hōʻike ʻia ka hoʻokele Manilin no ka hōʻike ʻana i kahi ʻano like ʻole o ka insulin i ke ʻano maʻi diabetes mellitus (o ke ʻano lua). Hiki ke hoʻohālikelike ʻia me kahi kūʻokoʻa kūʻokoʻa a i ʻole hui pū ai me nā lāʻau lapaʻau hypoglycemic ʻē aʻe. ʻO kahi ʻokoʻa kahi ʻo ka hui pū me nā glinides a me nā derebatives sulfonylurea. Hoʻokomo ʻia ka Ingestion o Maninil ma mua o ka papa ʻai, holoi ʻia a ʻū ʻole ʻole. Hoʻoholo ʻia ka dosage i kēlā me kēia lā e ka nānā ʻana o ka endocrinologist i hoʻokahi.
ma ka hoʻohana o ka lāʻau lapaʻau
Maninil
Nā Palaki
Pākaukau 1 papa:
Nā mea waiwai: glibenclamide (ma ke ʻano micronized) 1.75 mg.
Nā mea kūlike: ka lactose monohala, kākala hua, gimetellosa, colloidal silicon dioxide, magnesium stearate, crimson dye (Ponceau 4R) (E124)
i loko o nā pahu pahu o 120 pcs., i kahi ʻeke o nā kāleka 30 a 60 mau ʻona hoʻi.
Lapaʻau lāʻau
ʻO ka lāʻau lapaʻau hypoglycemic Oral mai ka hui o nā derivatives o ka sulfonylurea o ka lua o ka hanauna.
Hoʻonohonoho ia i ka hana huna o ka insulin i ka paa ʻana i ka pancreatic β-cell membrane receptors pololei, hōʻemi i ka paepae no ka pancreatic β-cell glucose irritation, hoʻonui i ka naʻau o ka insulin a me kona paʻa ʻana i nā cell target, hoʻonui i ka hoʻokuʻu ʻana i ka insulin, hoʻonui i ka hopena o ka insulin ma ka glucose glucose uptake a me ka ʻaʻi, ma ia mea e hōʻemi ai i ka ʻike o ka glucose i ka koko. Nā hana i ka lua o ka hana ʻana o ka inikini insulin. Mālama ia i ka lipolysis ma ka kiko adipose. Loaʻa ia i kahi hopena lipid-hoʻohaʻahaʻa, hoʻoemi i nā waiwai thrombogenic o ke koko.
ʻO Maninil® 1.5 a me Maninil® 3.5 i loko o ka micronized he mīkini kiʻekiʻe, ʻoi aku ka maikaʻi o ke kahua o ka glibenclamide, e ʻae ʻia ka lāʻau e holo koke ʻana mai ke kaʻe o ka digestive wikiwiki. I ka pili me ka hoʻokō ʻana o ka Cmax o glibenclamide i loko o ka plasma, ua like ka hopena hypoglycemic kokoke i ka manawa e hoʻonui ai i ka piʻi o ka glucose i ke koko ma hope o ka ʻai ʻana, ka mea e hōʻemi ai i ka hopena o ka lāʻau lapaʻau a me ka physiological. ʻO ka lōʻihi o ka hana hypoglycemic mau hola 20-24.
Hoʻopuka ka hopena hypoglycemic o ka lāʻau Maninil® 5 ma hope o 2 mau hola a lōʻihi 12 mau hola.
Kapehu
Ma hope o ka nānā ʻana i ka Maninil 1.75 a me Maninil 3.5, ʻike wikiwiki ʻia a kokoke hoʻi i ka hoʻopili ʻana mai ka ʻōpū o ka gastrointestinal. Hoʻokuʻu piha i ka microionized ikaika hana i loko o 5 mau minuke.
Ma hope o ka nānā ʻana o Maninil 5, ʻo ka hoʻopili ʻana mai ka ʻeha o ka gastrointestinal he 48-84%. Nā hola Tmax - nā hola 1-2.Aʻole bioavailability piha - 49-59%.
Kahele
ʻO ka pilina protein Plasma heʻoi aku ma mua o 98% no Maninil 1.75 a me Maninil 3.5, 95% no Maninil 5.
Metabolism a me ka hoʻopā ʻana
Ua aneane pau loa i ke kāʻei o ka ate me ka hoʻokumu ʻana o nā metabolites ʻelua i hana ʻia, kekahi o nā mea i hoʻopili ʻia e nā palaka, a me nā ʻē aʻe.
T1 / 2 no Maninil 1.75 a me Maninil 3.5 he 1.5-3.5 hola, no Maninil 5 - 3-16 hola.
ʻO ka maʻi diabetes mellitus type 2 (non-insulin-dependant) me ka hana ʻole o ka mālama ʻana i ka ʻaʻai, ʻoki kaumaha me ka momona a me ka hoʻoikaika kino.
Hypersensitivity (me nā lālani sulfonamide a me nā derivatives sulfonylurea), type 1 diabetes mellitus (insulin-depend), decabensation metabolic (ketoacidosis, precoma, coma), hōʻemi pancreatic, ʻeha nui a me nā maʻi o ka ʻōpū, kekahi mau maʻi kūlohelohe. (no ka laʻana, ka hoʻokaʻawale ʻana o nā metabolism i ka maʻi hopohopo, ke kau ʻana, nā hōʻeha a ma hope o nā hōʻeha nui ʻana i ka wā i hōʻike ʻia aku ai ka maʻi ʻana o ka insulin), leukopenia, ʻeha o ka ʻōpū, paresis o ka ʻōpū. nā kūlana i hele pū me ka malabsorption o ka meaʻai a me ka ulu ʻana o hypoglycemia, hapai a me ka manawa o ka umauma.
ʻO Maninyl 1.75 ka mea i lawe ʻia ma ke alo, kakahiaka a me ke ahiahi, ma mua o ka papaʻaina, me ka ʻaika ʻole. Hoʻomoe ʻia ka pākēkē i kēlā me kēia, ma muli o ka nui o ka maʻi.
ʻO ka ʻōmua mua he 1/2 papa, ʻo ka maʻamau he 2 papa. i kēlā me kēia lā, kiʻekiʻe loa - 3, ma nā hihia kūikawā - 4 papa. i ka la. Inā pono e lawe i nā dosis kiʻekiʻe o ka lāʻau (a hiki i ka 14 mg / lā), huli lākou i ka 3.5 mg maninil.
Hoʻokomo ʻia ka lāʻau lapaʻau no ka hoʻohana ʻana i ka wā hāpai a i ka wā a ka umauma.
I ka wā e ulu ai ka wā hāpai, pono e hoʻokuʻu ʻia ka lāʻau.
Hiki iā Hypoglycemia (me ka ʻai ʻana o ka ʻai, kahi overdose o ka lāʻau lapaʻau, me ka nui o ka hoʻoikaika kino, a me ka ʻai wai ʻona) nui ʻole.
Mai ka hanā hana ʻana: mau manawa - ka mualea, ka luaʻi ʻana, i kekahi mau hihia - jaundice cholestatic, hepatitis.
Mai ka ʻōnaehana hemopoietic: līpoki loa - thrombocytopenia, granulocytopenia, erythrocytopenia (a hiki i pancytopenia), i kekahi mau hihia - anemia hemolytic.
He maʻi kūloko: ʻaʻole i loaʻa pinepine - ka ʻupena o ka ʻili, ke kuni, ka ʻōpū, ka proteinuria.
Nā mea ʻē aʻe: i ka hoʻomaka ʻana o ka mālama ʻana, hiki i kahi maʻi noho hoʻololi ke hiki. I nā hanana pinepine, photosensitivity.
I ka wā o ka mālama ʻana me Maninil®, pono loa e hahai i nā ʻōlelo a ke kauka e pili ana i ka hoʻohana ʻana a me ka nānā ponoʻī ʻana i ke kaʻe o ka glucose o ke koko.
ʻO ka lōʻihi i ka noho ʻana i ka meaʻai, hiki ʻole i ka lako o ka nui o ka ʻai, ka hoʻoikaika kino kino, ke kū ʻana a i ʻole ka luaʻi a he hopena paha ka hypoglycemia.
ʻO ka hoʻohana like ʻana o nā lāʻau lapaʻau me ka hopena ma ka ʻōnaehana hoʻokoe ma waena, e hoʻohaʻahaʻa i ke koko (me nā beta-blockers), a me peripheral neuropathy, hiki ke uhi pū i nā hōʻailona o ka hypoglycemia.
I nā poʻe maʻi ʻelemakule, ʻoi aʻe ka kiʻekiʻe o ka uluʻana o ka hypoglycemia, no laila, he koho maikaʻi loa e pili ana i ka nui o ka lāʻau a me ka mālama pinepine ʻana i ka neʻe o ka glucose i ke koko ma loko o kahi ʻōpū ʻole a ma hope o ka ʻai, pono ʻia i ka hoʻomaka mua o ka mālama ʻana, pono.
Hiki i ke kīhāpai ke hoʻonāukiuki i ka hoʻomohala ʻana o ka hypoglycemia, me ka hoʻomohala ʻana o kahi ʻano disulfiram-like (nausea, luaʻi, ʻeha ʻana i ka ʻōpū, ʻike ʻana i ka wela ma ka ihu a me ke kino o luna, tachycardia, dizziness, headache), no laila e hōʻemi ʻoe i ka lawe ʻana i ka ʻona ma ke ʻano me Maninil®.
ʻO nā hōʻiliʻili nui a me nā hōʻeha, nā wela ākea, nā maʻi maʻi me ka febrile syndrome e koi ai i ka hoʻopau ʻana i nā lāʻau hypoglycemic waha a me ka hoʻokele ʻana o ka insulin.
I ka wā o ka mālama ʻana, ʻaʻole i ʻōlelo ʻia ka lōʻihi o ka hōʻike i ka lā.
I ka wā o ka mālama ʻana, pono e mālama nā mea maʻi i ka wā e alakaʻi ana i nā kaʻa a me nā hana ʻē aʻe ʻē aʻe e koi ai i ka nānā nui a me ka wikiwiki o ka hopena psychomotor.
ʻO ka hoʻonani ʻana i ka hopena hypoglycemic o Maninil® ka mea i ka wā e lawe ai i nā mea paʻa o ka ACE, nā mea hoʻohui a me nā keʻena male kāne, nā ʻenekini hypoglycemic oral (e.g., acarbose, biguanides) a me insulin, azapropazone, NSAIDs, beta-adrenergic blocking agents, chlorofibrinol derivatives, chinofenolone ona nā mea hui, derivatives Coumarin, disopyramide, fenfluramine, antifungal drug (miconazole, fluconazole), fluoxetine, MAO inhibitors, PA SC, pentoxifylline (i nā inikua kiʻekiʻe no ka hoʻokele makua), perhexylin, derivatif pyrazolone, phosphamides (e.g. cyclophosphamide, ifosfamide, trophosphamide), probenecid, salicylates, sulfonamides, tetracyclines a me tritoqualin.
Hoʻokomo ʻia nā ʻaihini e hoʻohuihui i ka urine (ammonium chloride, calcium chloride) i ka hopena o ka lāʻau Maninil® ma o ka hoʻemi ʻana i ke kiʻekiʻe o kāna kipi a hoʻonui i kona reabsorption.
ʻO ka hopena hypoglycemic o Maninil® hiki ke emi me ka hoʻohana pinepine ʻana o ka barbiturates, isoniazid, diazoxide, GCS, glucagon, nicotinates (ma nā helu koʻikoʻi), phenytoin, fenothiazines, rifampicin, thiazide diuretics, acetazolamide, contraceptives a me nā estropogen. , nā mea ʻala o nā hāmeʻa haʻalulu lohi, nā paʻakai lithium.
Hiki ke hoʻonāwaliwali i ka ʻawaʻawa o ka H2 receptor, ma ka lima, a hoʻonui i ka hopena hypoglycemic o Maninil® ma ka ʻaoʻao.
I nā hihia pilikia, hiki i ka pentamidine ke hōʻeha i kahi hoʻonui nui a hoʻonui paha i ka kaila glucose wai.
Me ka hoʻohana pinepine ʻana me ka lāʻau Maninil®, hiki i ka hopena o nā derivatives Coumarin a i emi paha a emi mai paha.
Me ka hoʻonui ʻia o ka hana hypoglycemic, beta-blockers, clonidine, guanethidine a me ka reserpine, a me ka lāʻau me ka hoʻokūkū kūloko o ka hana, hiki ke hoʻonāwaliwali i ka manaʻo o nā hōʻailona o ka hypoglycemia.
Nā hōʻailona: hypoglycemia (pōloli, hyperthermia, tachycardia, drowsiness, nāwaliwali, nāwaliwali o ka ʻili, nā puʻuwai ākea o nā neʻe, nā haʻalulu, nā hopohopo maʻamau, hopohopo, hōʻeha, ka maʻi palaualelo transient (e.g., ʻikea a me ka haʻi ʻana i ka maʻi, paresis a paralysis paha. ka loli ʻana o nā sensations.) Me ka holomua o ka hypoglycemia, hiki i nā mea maʻi ke nalowale i kā lākou pale a me ka ʻike, ka hoʻomohala ʻana i ka comog hypoglycemic.
Hanaʻia: ma ka hihia o ka hypoglycemia maʻalahi, pono ka mea maʻi e lawe i kahi ʻāpana o ke kō, nā meaʻai a i ʻole nā mea inu me kahi ʻona momona (ka meli, ka meli, kahi aniani o ke kīʻaha ʻona) i loko. I ka ʻike o ka nalowale o ka ʻike, pono ia e hoʻoili i ka glucose glucose - 40-80 ml o ka hopena o 40% dextrose (glucose), a laila infusion o 5-10% hopena o ka dextrose. A laila hiki iā ʻoe ke komo i ka 1 mg o ka glucagon i loko o / i, / m a i ʻole c / c. Inā ʻike ʻole ka mea maʻi i ka ʻike, a laila hiki ke hoʻomau i kēia ana; ʻoi aku ke koi ʻia o ka maʻi ikaika.
Store ma kahi pouli i loko o kahi mahana ʻaʻoleʻoi aku ma mua o 25 ° C.
3 mau makahikiHōʻanoʻike
Nā kuʻuna i ka hoʻonohonoho ʻana a me nā hōʻike no ka hoʻohana
Ke poʻo inoa He kumukūʻai ma Rusia Kumukūʻai ma Ukraine ʻO Glibenclamide Glibenclamide 30 ʻōpala 7 UAH ʻO ka Glibenclamide-Health Glibenclamide -- 12 UAH Nā kumuhana ma o ka hōʻike ʻana a me ke ʻano o ka hoʻohana ʻana
Ke poʻo inoa He kumukūʻai ma Rusia Kumukūʻai ma Ukraine Glyurenorm glycidone 94 ʻōpala 43 UAH ʻO Bisogamma Glyclazide 91 ʻōpala 182 UAH ʻO Glidiab Glyclazide 100 rub 170 UAH Diabeton MR -- 92 UAH Diagnizide mr Gliclazide -- 15 UAH ʻO Glidia MV Gliclazide -- -- ʻO Glykinorm Gliclazide -- -- Hoʻolaha ʻia Gliclazide 231 rub 57 UAH Glyclazide 30 MV-Indar Glyclazide -- -- Hoʻolaha-Hoʻolima Glyclazide-Health -- 36 UAH ʻO Glioral Glyclazide -- -- Hoʻolaha Glaclazide Diagnizide -- 14 UAH Diazide MV Gliclazide -- 46 UAH Osliklid Gliclazide -- 68 UAH Gliclazide Diadeon -- -- ʻO Glyclazide MV Gliclazide 4 ʻōpala -- Amaril 27 ʻōpala 4 UAH Glimepiride ʻO Glemaz -- -- Hoʻolaha ʻia ka inoa momona -- 77 UAH ʻO Glimepiride Glyride -- 149 UAH Diapiride Glimepiride -- 23 UAH Alarahi -- 12 UAH Hoʻolālā ʻia ʻo Glimax -- 35 UAH Gimepiride-Lugal glimepiride -- 69 UAH Clay glimepiride -- 66 UAH Glabepiride diabrex -- 142 UAH Nā glimepiride ʻo Meglimide -- -- Melpamide Glimepiride -- 84 UAH ʻO ka glimepiride Perinel -- -- Hoʻohui -- -- Kahiʻu -- -- Gimepiride glimepiride 27 ʻōpala 42 UAH ʻO Glimepiride-teva glimepiride -- 57 UAH Gimepiride Canon glimepiride 50 ʻōpala -- ʻO Glimepiride Pharmstandard glimepiride -- -- Dimaril glimepiride -- 21 UAH ʻO Glamepiride diamerid 2 hoʻoheʻe -- Ka ʻokoʻa like, hiki ke pili pū i ka hōʻike a me ke ʻano o ka noi
Ke poʻo inoa He kumukūʻai ma Rusia Kumukūʻai ma Ukraine Avantomed rosiglitazone, metformin hydrochloride -- -- Bagometua Metformin -- 30 UAH He metformin Glucofage 12 ʻōpala 15 UAH Huʻi ʻia ka metformin xr -- 50 UAH ʻO Reduxin Met Metinin, ʻo Sibutramine 20 ʻōpala -- Dianormet -- 19 UAH Metformin Diaformin -- 5 UAH ʻO ke metformin metformin 13 ʻōpala 12 UAH Metformin metozin metformin -- 13 UAH Siofor 208 ʻōpala 27 UAH ʻO ka metformin hydrochloride -- -- ʻO Emnorm EP Metformin -- -- Megifort Metformin -- 15 UAH Metamine Metformin -- 20 UAH Metamine SR Metformin -- 20 UAH Metfogamma metformin 256 ʻōpala 17 UAH ʻO Tefor metformin -- -- Glycometer -- -- Glycomet SR -- -- Kālaiʻa 37 ʻōpala -- Metformin Canon metformin, ovidone K 90, mauʻa palaoa, crospovidone, magnesium stearate, talc 26 ʻōpala -- Insuffor metformin hydrochloride -- 25 UAH Metformin-teva metformin 43 ʻōpala 22 UAH Diaformin SR metformin -- 18 UAH Mepharmil Metformin -- 13 UAH Metformin Metformin -- -- Amaryl M Limepiride Maikaʻi ʻia, Metformin Hydrochloride 856 ʻōpala 40 UAH ʻO ka glibenclamide glibomet, metformin 257 ʻōpala 101 UAH ʻO Glucovans glibenclamide, metformin 34 ʻōpala 8 UAH Dianorm-m Glyclazide, Metformin -- 115 UAH Dibizid-m glipizide, metformin -- 30 UAH Douglimax glimepiride, metformin -- 44 UAH Duotrol glibenclamide, metformin -- -- Hoʻolauleʻa 45 kahi -- Glibofor metformin hydrochloride, glibenclamide -- 16 UAH Avandamet -- -- Avandaglim -- -- ʻO metumin metumin, sitagliptin 9 ʻōpala 1 UAH Velmetia metformin, sitagliptin 6026 rub -- Galvus Met vildagliptin, metformin 259 ʻōpala 1195 UAH ʻO glimepiride Tripride, metformin, pioglitazone -- 83 UAH Huihui XR metformin, saxagliptin -- 424 UAH Metformin Comboglyz Prolong, saxagliptin 130 ʻōpala -- Gentadueto linagliptin, metformin -- -- ʻO ka metformin Vipdomet, alogliptin 55 ʻ .pū 1750 UAH Sinjardi empagliflozin, metformin hydrochloride 240 ʻōpala -- ʻO Voglibose Oxide -- 21 UAH He pioglitazone Glutazone -- 66 UAH ʻO Dropia Sanovel pioglitazone -- -- ʻO Jasonvia sitagliptin 1369 ʻōpala 277 UAH Galvus vildagliptin 245 ʻōpala 895 UAH Onglisa saxagliptin 1472 ʻōpala 48 UAH Nesina alogliptin -- -- Vipidia alogliptin 350 ʻōpala 1250 UAH Trazhenta linagliptin 89 ʻōpala 1434 UAH Lixumia lixisenatide -- 2498 UAH Guanem guar gum 9950 ʻōpala 24 UAH Hoʻopau ka Insvada -- -- ʻO Novonorm Repaglinide 30 ʻōpala 90 UAH Hoʻokomo ʻo Repodiab Repaglinide -- -- Baeta Exenatide 150 ʻōpala 4600 UAH Baeta Long Exenatide 10248 ʻōpala -- Viktoza liraglutide 8823 kahaki 2900 UAH Saxenda liraglutide 1374 ʻōpala 13773 UAH Forksiga Dapagliflozin -- 18 UAH Forsiga Dapagliflozin 12 ʻōpala 3200 UAH Invocana canagliflozin 13 ʻōpala 3200 UAH Jardins Empagliflozin 222 ʻōpala 566 UAH Trulicity Dulaglutide 115 ʻōpala -- Pehea e ʻike ai i kahi analogue ʻano maʻalahi o kahi lāʻau lapaʻau nui?
Nā hōʻailona no ka hoʻohana ʻana
ʻO nā hiʻohiʻona o ka dosage a me nā hoʻokele
ʻO ka hoʻoholo i nā kumu no ke koho ʻana i kahi hoʻoponopono lapaʻau ka nui o nā makahiki, ka nui o ka maʻi, a me ka ʻike ʻana i ka glucose i ke koko ma ka ʻōpū ʻole a ma hope o ka ʻai ʻana ma hope o 2 mau hola.
Ma kahi o ka haʻahaʻa o ka hana a ke kauka i ʻōlelo ʻia e kekahi kauka, hiki ke hoʻoholo ʻia i ka nui. ʻO ke kaʻina o ka hoʻonui ʻana i ka dosage a hiki i ka pae kiʻekiʻe ka hoʻokō ʻia - mai 2 a 7, mau lā ma lalo o ka mākaʻi o kahi kauka.
Ma ka hihia o Maninil mai nā lāʻau lapaʻau ʻē aʻe me ka hopena hypoglycemic, ua kuhikuhi ʻia kona keʻena ma kahi ʻano nui, inā pono, hoʻonui ʻia, hana maikaʻi ʻia a ʻokoʻa ma lalo o ka mālama maʻi.
Nā Hana Kūloko Muaʻo Maninil:
- mau mea 1.75 mg o ka laoa ikaika - iā 1-2 mau papa i ka lā hoʻokahi. ʻOi aku ka nui loa ma mua o ka 6 papa i ka lā,
- nona ka 3.5 mg o ka hana ikaika - Nānā 1 / 2-1 papa i hoʻokahi lā. ʻO ka nui maʻa loa he 3 papa i kēlā me kēia lā,
- nona ka 5 mg o ka launa ikaika - ka ½1-1 papa 1 ka manawa i ka lā. ʻO ka dosie ka palena kiʻekiʻe loa i ke ao he 3 mau papa.
ʻOi aku ka ʻelemakule (ʻoi aku ma mua o 70 mau makahiki), ka poʻe e pili ana i nā mea paʻa, a me ka poʻe i loaʻa i ka puʻuwai kino a i ʻole ka palupalu ʻana i loko o ka maʻi, ua manaʻo ʻia e hoʻohana i nā hōʻemi o ka lāʻau lapaʻau ma muli o ka hoʻoweliweli ʻana o ka hypoglycemia.
Inā poina ʻoe i hoʻokahi kauʻai, hana ʻia kahi manamana hou ma Maninil i kahi pāʻālua maʻamau (ʻaʻole i hoʻonui) i ka manawa maʻamau.
Nā hopena hopena
Hoʻowahāwahā ka maʻi maʻi i kēia lāʻau e like me ke ahi!
Pono ʻoe e koi ...
ʻO ka hiʻohiʻona o nā haunaele i ka hana o kekahi mau ʻōnaehana e nānā pono ana iā Maninil e nānā pinepine ʻole ʻia nei. Hiki i kā lākou ʻike kikoʻī:
- mai ka maʻi ʻeha o ka gastrointestinal - i ke ʻano o ka nausea, ka belching, ka ʻeha o ke kaumaha i loko o ka ʻōpū, ka hiʻohiʻona o ka ʻaha metallic i loko o ka waha, ʻohi,
- mai ka akio - i ke ʻano o ka hoʻōla pōkole o nā huina o nā ate, ka hoʻomohala ʻana o ka cholestasis intrahepatic a i ʻole hepatitis,
- mai ka aoao o ka metabolism - i ke ʻano o ka paona a me ka hypoglycemia me kāna mau hiʻohiʻona - ka haʻalulu, nui ka hoʻonui ʻana, ka hū ʻana, hoʻomoe ʻia ka moe, hopohopo, migraine, ʻike ʻole a haʻi ʻia paha ka ʻōlelo,
- ma ka ʻāpana o ka pale ʻana - i loko o nā ʻano like ʻole i kūlike i ka ʻāhiu - petechiae, haki, hyperthermia, photosensitivity a me nā mea ʻē aʻe,
- mai ka ʻōnaehana hematopoietic - i loko o ka ʻano o thrombocytopenia, anemia hemolytic, erythrocytopenia,
- ma ka aoao o na kiko mele - ma ke ʻano o kahi kolohe o ka noho ʻana.
ʻO ke kuhi koʻikoʻi ʻoiai e lawe ana iā Maninil i ka mālama pono ʻana i nā ʻōlelo olakino e pili ana i ka meaʻai a me ka hoʻoliʻi kūlohelohe o ka glucose glucose. Ma kahi o kahi overdose, hiki i ka hypoglycemia ke ulu pū me kāna mau hōʻailona ʻano.
I ka hihia o nā hōʻailona kūlohelohe o ka overdose, ua paipai ʻia e ʻai i kahi kōpili liʻiliʻi a i ʻole nā meaʻai momona me ka hoʻoweliweli maʻalahi. E pili ana i nā ʻano maʻi overdose, iv ka hoʻonāukiuki ʻana i ka hopena o ka glucose. Ma kahi o glucose, ʻae ʻia a ʻoi aku hoʻi e hoʻopaʻa ʻia ka hoʻonāukiuki a ka maʻiagonona.
Hoʻopilikia ka hopena o ka hypoglycemia inā:
- mea inu waiʻona
- nele o nā kīnā
- lōʻihi ka lau ʻana ma waena o nā papaʻai,
- hōkeo a iʻa paha,
- hoʻoikaika ikaika kino.
Hiki ke uhiʻia nā hōʻailona o ka hypoglycemia i ka wā e lawe ana i ka Maninil me nā lāʻau lapaʻau e pili ana i ka ʻoihana sentral a i ʻole e hoʻohaʻahaʻa i ke koko.
Hiki ke hoʻemi ʻia ka hopena o Maninil aʻo ka mea i hoʻohana ʻia me ka barbiturates, ka mana hoʻomalu a me nā lāʻau lapaʻau hou e pili ana i ka hormone. A ma nā mea ʻē aʻe, ka hoʻohana like ʻana o nā anticoagulants, reserpine, tetracyclines, hiki i nā anabolic steroid ke hoʻomaikaʻi i kāna hana.
Kūʻai a me nā contraindications
Ke mālama nei me Maninil, e aʻo ʻia e pale aku i ka lohi o ka lā, a me ka hoʻomaʻamaʻa ʻana ʻana i ka wā e hoʻokele ana i kahi kaʻa, hoʻokō i nā mea ʻē aʻe e koi ai i ka manaʻo, ʻike, a me nā hana wikiwiki.
Ka lāʻau hypoglycemic contraindicated ma ka hanana o ka:
- maʻi diabetes-hilinaʻi
- pūpū hema
- ālai ʻole,
- maʻi maʻamau ketoacidosis,
- coma maʻiʻai ʻole precoma,
- paresis o ka ʻōpū
- leukopenia
- lactose intolerance a me ka nele o ka lactase,
- hoʻonui mahanū i ka mea ikaika - glibenclamide a i ʻole nā mea ʻē aʻe i loaʻa i ka waihona o ka lāʻau,
- hypersensitivity a PSM, a me sulfonamides a me diuretics e pili ana i nā hua palapala o ka hui sulfonamide,
- ka hemo o ka pancreas.
ʻO ka hoʻopau ʻana o Maninil a me kāna hoʻololi me ka insulin i hana ʻia inā:
- nā maʻi hopuna i hele pū ʻia me nā mea hōʻike febrile,
- kaʻina hoʻopunipuni kaʻenehana
- pālahalaha nui,
- nā hōʻeha
- ʻo ka ʻōpū a i ʻole ka mea e pono ai no ka pale umauma.
Me ka mālama aka, pono e lawe ʻia kēia lāʻau lapaʻau i mua o nā hana o ka pala o ka thyroid gland, adrenal cortex, ʻāʻī hoʻonaninani i lawe ʻia e ka inu ʻawaʻawa.
Hoʻokomo ʻia kahi lāʻau hypoglycemic maʻi i nā keiki.
Pehea e hoʻololi ai iā Maninil: nā mea hoʻohui a me nā kumu kūʻai
E like me ka hapa nui o ka lāʻau āpau, he hoʻohiwahiwa a me nā kūmole Maninil. ʻO ka hana like kekahi nui o nā lāʻau lapaʻau e hoʻohiolo ana i ke kō, ʻo ia ka mea ikaika e hoʻōla nei i ka glibenclamide.
Nā Maninyl 3,5 analogues:
- ʻO Glibomet - mai 339 mau rubles,
- ʻO Glibenclamide - mai 46 mau rubles,
- Maninil 5 - mai 125 rubles.
ʻO nā maʻi me ka mahalo i nā analogues, he nui nā nīnau, no ka mea, ʻoi aku ka maikaʻi - Maninil a i Glibenclamide paha? I kēia hihia, maʻalahi nā mea āpau. ʻO Glibenclamide ʻo Maninil. ʻO ka lua wale nō kahi kūlana kiʻekiʻe e hoʻohālikelike nei i ka hana o ka mua.
A ʻoi aʻe ka maikaʻi - Maninil a i ʻole Glidiab? I kēia hihia, ʻaʻohe pane koʻikoʻi, no ka mea e hilinaʻi i kēlā me kēia ʻano o ka mea maʻi.
Nā hōʻikeʻike o Maninil no ke ʻano maʻi type 2 ma ka hopena therapeutic:
- ʻO Amaril - mai 350 rubles,
- Vazoton - mai 246 mau rubles,
- ʻO Arfazetin - mai 55 mau rubles,
- Kūkulu - mai nā 127 rubles,
- Listata - mai 860 rubles,
- Diabeton - mai 278 mau rubles,
- Xenical - mai 800 rubles,
- me nā mea ʻē aʻe.
Ke koho nei i kahi kikoʻī o Maninil, hōʻike ka poʻe loea i ka makemake ʻana i nā lāʻau lapaʻau i hana ʻia e nā ʻenehana Kepani, ʻAmelika a me ʻEulopa: ʻo Green Richter, Krka, Zentiv, Hexal a me nā mea ʻē aʻe.
ʻŌlelo aʻo Maninil
NA ININA E hoʻokuʻu i ke ʻano Hōʻike ʻOhiʻohi Ka hana lāʻau lapaʻau Lapaʻau lāʻau Maninil, hōʻike hōʻailona no ka hoʻohana ʻana Nā Hoʻohui ʻLoe a me ke kākele ʻŌpū a me ka lactation Nā hopena hopena Nā ʻōlelo kikoʻī Hoʻokomo i ka hiki ke lawe i nā kaʻa a me nā mīkini ʻē aʻe e koi ai i ka nui o ka makaʻala Hoʻohui nūhou Ke keu Nā kūlana mālama ʻO ka lā kau
ma ka hoʻohana o ka lāʻau lapaʻau
Maninil
Nā Palaki
Pākaukau 1 papa:
Nā mea waiwai: glibenclamide (ma ke ʻano micronized) 1.75 mg.
Nā mea kūlike: ka lactose monohala, kākala hua, gimetellosa, colloidal silicon dioxide, magnesium stearate, crimson dye (Ponceau 4R) (E124)
i loko o nā pahu pahu o 120 pcs., i kahi ʻeke o nā kāleka 30 a 60 mau ʻona hoʻi.
Lapaʻau lāʻau
ʻO ka lāʻau lapaʻau hypoglycemic Oral mai ka hui o nā derivatives o ka sulfonylurea o ka lua o ka hanauna.
Hoʻonohonoho ia i ka hana huna o ka insulin i ka paa ʻana i ka pancreatic β-cell membrane receptors pololei, hōʻemi i ka paepae no ka pancreatic β-cell glucose irritation, hoʻonui i ka naʻau o ka insulin a me kona paʻa ʻana i nā cell target, hoʻonui i ka hoʻokuʻu ʻana i ka insulin, hoʻonui i ka hopena o ka insulin ma ka glucose glucose uptake a me ka ʻaʻi, ma ia mea e hōʻemi ai i ka ʻike o ka glucose i ka koko. Nā hana i ka lua o ka hana ʻana o ka inikini insulin. Mālama ia i ka lipolysis ma ka kiko adipose. Loaʻa ia i kahi hopena lipid-hoʻohaʻahaʻa, hoʻoemi i nā waiwai thrombogenic o ke koko.
ʻO Maninil® 1.5 a me Maninil® 3.5 i loko o ka micronized he mīkini kiʻekiʻe, ʻoi aku ka maikaʻi o ke kahua o ka glibenclamide, e ʻae ʻia ka lāʻau e holo koke ʻana mai ke kaʻe o ka digestive wikiwiki. I ka pili me ka hoʻokō ʻana o ka Cmax o glibenclamide i loko o ka plasma, ua like ka hopena hypoglycemic kokoke i ka manawa e hoʻonui ai i ka piʻi o ka glucose i ke koko ma hope o ka ʻai ʻana, ka mea e hōʻemi ai i ka hopena o ka lāʻau lapaʻau a me ka physiological. ʻO ka lōʻihi o ka hana hypoglycemic mau hola 20-24.
Hoʻopuka ka hopena hypoglycemic o ka lāʻau Maninil® 5 ma hope o 2 mau hola a lōʻihi 12 mau hola.
Kapehu
Ma hope o ka nānā ʻana i ka Maninil 1.75 a me Maninil 3.5, ʻike wikiwiki ʻia a kokoke hoʻi i ka hoʻopili ʻana mai ka ʻōpū o ka gastrointestinal. Hoʻokuʻu piha i ka microionized ikaika hana i loko o 5 mau minuke.
Ma hope o ka nānā ʻana o Maninil 5, ʻo ka hoʻopili ʻana mai ka ʻeha o ka gastrointestinal he 48-84%. Nā hola Tmax - nā hola 1-2.Aʻole bioavailability piha - 49-59%.
Kahele
ʻO ka pilina protein Plasma heʻoi aku ma mua o 98% no Maninil 1.75 a me Maninil 3.5, 95% no Maninil 5.
Metabolism a me ka hoʻopā ʻana
Ua aneane pau loa i ke kāʻei o ka ate me ka hoʻokumu ʻana o nā metabolites ʻelua i hana ʻia, kekahi o nā mea i hoʻopili ʻia e nā palaka, a me nā ʻē aʻe.
T1 / 2 no Maninil 1.75 a me Maninil 3.5 he 1.5-3.5 hola, no Maninil 5 - 3-16 hola.
ʻO ka maʻi diabetes mellitus type 2 (non-insulin-dependant) me ka hana ʻole o ka mālama ʻana i ka ʻaʻai, ʻoki kaumaha me ka momona a me ka hoʻoikaika kino.
Hypersensitivity (me nā lālani sulfonamide a me nā derivatives sulfonylurea), type 1 diabetes mellitus (insulin-depend), decabensation metabolic (ketoacidosis, precoma, coma), hōʻemi pancreatic, ʻeha nui a me nā maʻi o ka ʻōpū, kekahi mau maʻi kūlohelohe. (no ka laʻana, ka hoʻokaʻawale ʻana o nā metabolism i ka maʻi hopohopo, ke kau ʻana, nā hōʻeha a ma hope o nā hōʻeha nui ʻana i ka wā i hōʻike ʻia aku ai ka maʻi ʻana o ka insulin), leukopenia, ʻeha o ka ʻōpū, paresis o ka ʻōpū. nā kūlana i hele pū me ka malabsorption o ka meaʻai a me ka ulu ʻana o hypoglycemia, hapai a me ka manawa o ka umauma.
ʻO Maninyl 1.75 ka mea i lawe ʻia ma ke alo, kakahiaka a me ke ahiahi, ma mua o ka papaʻaina, me ka ʻaika ʻole. Hoʻomoe ʻia ka pākēkē i kēlā me kēia, ma muli o ka nui o ka maʻi.
ʻO ka ʻōmua mua he 1/2 papa, ʻo ka maʻamau he 2 papa. i kēlā me kēia lā, kiʻekiʻe loa - 3, ma nā hihia kūikawā - 4 papa. i ka la. Inā pono e lawe i nā dosis kiʻekiʻe o ka lāʻau (a hiki i ka 14 mg / lā), huli lākou i ka 3.5 mg maninil.
Hoʻokomo ʻia ka lāʻau lapaʻau no ka hoʻohana ʻana i ka wā hāpai a i ka wā a ka umauma.
I ka wā e ulu ai ka wā hāpai, pono e hoʻokuʻu ʻia ka lāʻau.
Hiki iā Hypoglycemia (me ka ʻai ʻana o ka ʻai, kahi overdose o ka lāʻau lapaʻau, me ka nui o ka hoʻoikaika kino, a me ka ʻai wai ʻona) nui ʻole.
Mai ka hanā hana ʻana: mau manawa - ka mualea, ka luaʻi ʻana, i kekahi mau hihia - jaundice cholestatic, hepatitis.
Mai ka ʻōnaehana hemopoietic: līpoki loa - thrombocytopenia, granulocytopenia, erythrocytopenia (a hiki i pancytopenia), i kekahi mau hihia - anemia hemolytic.
He maʻi kūloko: ʻaʻole i loaʻa pinepine - ka ʻupena o ka ʻili, ke kuni, ka ʻōpū, ka proteinuria.
Nā mea ʻē aʻe: i ka hoʻomaka ʻana o ka mālama ʻana, hiki i kahi maʻi noho hoʻololi ke hiki. I nā hanana pinepine, photosensitivity.
I ka wā o ka mālama ʻana me Maninil®, pono loa e hahai i nā ʻōlelo a ke kauka e pili ana i ka hoʻohana ʻana a me ka nānā ponoʻī ʻana i ke kaʻe o ka glucose o ke koko.
ʻO ka lōʻihi i ka noho ʻana i ka meaʻai, hiki ʻole i ka lako o ka nui o ka ʻai, ka hoʻoikaika kino kino, ke kū ʻana a i ʻole ka luaʻi a he hopena paha ka hypoglycemia.
ʻO ka hoʻohana like ʻana o nā lāʻau lapaʻau me ka hopena ma ka ʻōnaehana hoʻokoe ma waena, e hoʻohaʻahaʻa i ke koko (me nā beta-blockers), a me peripheral neuropathy, hiki ke uhi pū i nā hōʻailona o ka hypoglycemia.
I nā poʻe maʻi ʻelemakule, ʻoi aʻe ka kiʻekiʻe o ka uluʻana o ka hypoglycemia, no laila, he koho maikaʻi loa e pili ana i ka nui o ka lāʻau a me ka mālama pinepine ʻana i ka neʻe o ka glucose i ke koko ma loko o kahi ʻōpū ʻole a ma hope o ka ʻai, pono ʻia i ka hoʻomaka mua o ka mālama ʻana, pono.
Hiki i ke kīhāpai ke hoʻonāukiuki i ka hoʻomohala ʻana o ka hypoglycemia, me ka hoʻomohala ʻana o kahi ʻano disulfiram-like (nausea, luaʻi, ʻeha ʻana i ka ʻōpū, ʻike ʻana i ka wela ma ka ihu a me ke kino o luna, tachycardia, dizziness, headache), no laila e hōʻemi ʻoe i ka lawe ʻana i ka ʻona ma ke ʻano me Maninil®.
ʻO nā hōʻiliʻili nui a me nā hōʻeha, nā wela ākea, nā maʻi maʻi me ka febrile syndrome e koi ai i ka hoʻopau ʻana i nā lāʻau hypoglycemic waha a me ka hoʻokele ʻana o ka insulin.
I ka wā o ka mālama ʻana, ʻaʻole i ʻōlelo ʻia ka lōʻihi o ka hōʻike i ka lā.
I ka wā o ka mālama ʻana, pono e mālama nā mea maʻi i ka wā e alakaʻi ana i nā kaʻa a me nā hana ʻē aʻe ʻē aʻe e koi ai i ka nānā nui a me ka wikiwiki o ka hopena psychomotor.
ʻO ka hoʻonani ʻana i ka hopena hypoglycemic o Maninil® ka mea i ka wā e lawe ai i nā mea paʻa o ka ACE, nā mea hoʻohui a me nā keʻena male kāne, nā ʻenekini hypoglycemic oral (e.g., acarbose, biguanides) a me insulin, azapropazone, NSAIDs, beta-adrenergic blocking agents, chlorofibrinol derivatives, chinofenolone ona nā mea hui, derivatives Coumarin, disopyramide, fenfluramine, antifungal drug (miconazole, fluconazole), fluoxetine, MAO inhibitors, PA SC, pentoxifylline (i nā inikua kiʻekiʻe no ka hoʻokele makua), perhexylin, derivatif pyrazolone, phosphamides (e.g. cyclophosphamide, ifosfamide, trophosphamide), probenecid, salicylates, sulfonamides, tetracyclines a me tritoqualin.
Hoʻokomo ʻia nā ʻaihini e hoʻohuihui i ka urine (ammonium chloride, calcium chloride) i ka hopena o ka lāʻau Maninil® ma o ka hoʻemi ʻana i ke kiʻekiʻe o kāna kipi a hoʻonui i kona reabsorption.
ʻO ka hopena hypoglycemic o Maninil® hiki ke emi me ka hoʻohana pinepine ʻana o ka barbiturates, isoniazid, diazoxide, GCS, glucagon, nicotinates (ma nā helu koʻikoʻi), phenytoin, fenothiazines, rifampicin, thiazide diuretics, acetazolamide, contraceptives a me nā estropogen. , nā mea ʻala o nā hāmeʻa haʻalulu lohi, nā paʻakai lithium.
Hiki ke hoʻonāwaliwali i ka ʻawaʻawa o ka H2 receptor, ma ka lima, a hoʻonui i ka hopena hypoglycemic o Maninil® ma ka ʻaoʻao.
I nā hihia pilikia, hiki i ka pentamidine ke hōʻeha i kahi hoʻonui nui a hoʻonui paha i ka kaila glucose wai.
Me ka hoʻohana pinepine ʻana me ka lāʻau Maninil®, hiki i ka hopena o nā derivatives Coumarin a i emi paha a emi mai paha.
Me ka hoʻonui ʻia o ka hana hypoglycemic, beta-blockers, clonidine, guanethidine a me ka reserpine, a me ka lāʻau me ka hoʻokūkū kūloko o ka hana, hiki ke hoʻonāwaliwali i ka manaʻo o nā hōʻailona o ka hypoglycemia.
Nā hōʻailona: hypoglycemia (pōloli, hyperthermia, tachycardia, drowsiness, nāwaliwali, nāwaliwali o ka ʻili, nā puʻuwai ākea o nā neʻe, nā haʻalulu, nā hopohopo maʻamau, hopohopo, hōʻeha, ka maʻi palaualelo transient (e.g., ʻikea a me ka haʻi ʻana i ka maʻi, paresis a paralysis paha. ka loli ʻana o nā sensations.) Me ka holomua o ka hypoglycemia, hiki i nā mea maʻi ke nalowale i kā lākou pale a me ka ʻike, ka hoʻomohala ʻana i ka comog hypoglycemic.
Hanaʻia: ma ka hihia o ka hypoglycemia maʻalahi, pono ka mea maʻi e lawe i kahi ʻāpana o ke kō, nā meaʻai a i ʻole nā mea inu me kahi ʻona momona (ka meli, ka meli, kahi aniani o ke kīʻaha ʻona) i loko. I ka ʻike o ka nalowale o ka ʻike, pono ia e hoʻoili i ka glucose glucose - 40-80 ml o ka hopena o 40% dextrose (glucose), a laila infusion o 5-10% hopena o ka dextrose. A laila hiki iā ʻoe ke komo i ka 1 mg o ka glucagon i loko o / i, / m a i ʻole c / c. Inā ʻike ʻole ka mea maʻi i ka ʻike, a laila hiki ke hoʻomau i kēia ana; ʻoi aku ke koi ʻia o ka maʻi ikaika.
Store ma kahi pouli i loko o kahi mahana ʻaʻoleʻoi aku ma mua o 25 ° C.
3 mau makahiki