Pehea e hoʻohana ai iā Lorista N no ka maʻi maʻi

ʻO Lorista ® N - kahi lāʻau hui hoʻohui, loaʻa kahi hopena hypotensive.

Losartan. ʻO ka antagonist e pili ana i ka angiotensin II (type AT 1) no ka hoʻokūkū waha, ʻaʻohe ʻano o ka protein. Ke vivo a i loko o vitro losartan a me kāna hana olaiola e hiki ai i ka pākeke (EXP-3174) e kāohi i nā hopena koʻikoʻi a ka physiologically nui o ka angiotensin II ma ka ʻĀpana AT 1.

Hoʻololi ʻo Losartan i ka hana ʻana i nā mea hoʻoponopono o ka AT 2 e ka hoʻonui ʻana i ka pae o ka angiotensin II.

ʻAʻole ʻo Losartan i kāohi i ka hana o ka kininase II, he enzyme e pili ana i ka metabolism o ka bradykinin.

Hoʻēmi i ka OPSS, ka hoʻokaumaha ʻia i ke kahe ʻo ka "liʻiliʻi" o ke kahe o ke koko, e hōʻemi ana ma hope o ke kaumaha, he hopena diuretic.

Kūleʻa ʻia me ka hoʻomohala ʻana o ka hypertrophy myocardial, hoʻonui i ka hoʻolahalaha ʻana i nā maʻi me nā maʻi ʻoi ʻole ka maʻi. ʻO ka lawe ʻana i ka losartan i kahi lā e alakaʻi i ka emi ʻana o ka helu nui ma SBP a me DBP. Ka ʻoluʻolu i ka wailele o Losartan ma ke ao, aʻo ka hopena antihypertensive e pili i ka ʻenikani circadian kūlohelohe. ʻO ka emi o ke kahe o ke koko i ka hopena o ka hopena o ka lāʻau lapaʻau ma kahi o 70-80% o ka hopena i ka hopena o ka lāʻau, 5-6 mau hola ma hope o ke lawelawe ʻana. ʻAʻole mālama ʻia ka maʻi kahalike, a ʻaʻohe o ka losartan i ka hopena koʻikoʻi ma o ka puʻuwai puʻuwai.

Maikaʻi ʻo Losartan i nā kāne a me nā wahine, ʻoiai ʻo ia i nā ʻelemakule (ma mua o 65 mau makahiki) a me nā mea maʻi (ma lalo o 65 mau makahiki).

ʻO ka hole waiwai. A diuretic thiazide, ka hopena diuretic e pili ana me ka reabsorption impaired o ka sodium, chlorine, potassium, magnesium, wai i loko o ka nealron mamao, nā mea hoʻokaʻawale i nā excretion o nā ions calcium, uric acid. He mau waiwai antihypertensive. ʻAʻohe hopena i kahi kahe koko maʻamau.

Hoʻolaha ka hopena diuretic ma hope o nā hola 1-2, hiki i ka lōʻihi ma hope o 4 mau hola a lōʻihi i nā hola 6-12. ʻO ka hopena antihypertensive e hele mai ma hope o nā lā 3-4, akā hiki paha i nā 3-4 mau wiki e hoʻokō ai i ka hopena therapeutic hopena.

Lapaʻau lāʻau

ʻO nā pharmacokinetics o losartan a me hydrochlorothiazide i ka manawa i lawe pinepine ʻia, ʻaʻole i ʻokoʻa ia mai ka wā i hoʻokaʻawale ʻia.

Losartan. Ua hoʻonoono maikaʻi ʻia mai ka papa hana ʻole. Hana ia i ka metabolism koʻikoʻi ma ka "papa mua" ma o ka ate, ka hana ʻana o ka metabolite ikaika (EXP-3174) me ka waikua carboxylic a me nā metabolite ʻaʻole i kaʻe. ʻO ka bioavailability e pili ana i ka 33%. ʻO ka lawe ʻana i ka lāʻau me ka meaʻai, ʻaʻohe hopena koʻikoʻi ʻoi loa e pili ana i ka serum. T max - 1 hola ma hope o ka lawelawe waha, a me kāna hoʻolaʻa neʻe (EXP-3174) - 3-4 mau hola.

ʻOi aku ma mua o ka 99% o losartan a me EXP-3174 e nakinaki ai i nā protein plasma, ʻoi loa me ka albumin. ʻO ka nui o ka hoʻonuiʻana i ka losartan he 34 pā. E komo pū ana i loko o ka BBB.

Hoʻohui ʻia ka Losartan me ka hoʻokumu ʻana o ka metabolite ikaika (EXP-3174) (14%) a i ʻole hana, ʻo ia hoʻi nā 2 nui o nā metabolites i hoʻomohala ʻia e ka hydroxylation o nā pūʻulu butyl o ka kaulahao, a me kahi metabolite liʻiliʻi ʻole - N-2-tetrazole glucuronide.

ʻO ka wehe i ka plasma o ka losartan a me kāna metabolite hoʻoikaika e like me 10 ml / s (600 ml / min) a me 0.83 ml / s (50 ml / min), kēlā me ia. ʻO ka hoʻomaʻemaʻe ʻana i ka renal o ka losartan a me kāna metabolite hoʻoikaika e pili ana i ka 1.23 ml / s (74 ml / min) a me 0.43 ml / s (26 ml / min). T 1/2 o ka losartan a me ka metabolite ikaika e 2 mau hola a i nā hola 6-9, kēlā me kēia. Hoʻokuʻu ʻia ia ma ka bile - 58%, nā pēpē - 35%.

ʻO ka hole waiwai. Ma hope o ka lawelawe waha, ʻo ka hoʻokomo ʻana o ka hydrochlorothiazide, ʻo 60-80%. C max hydrochlorothiazide i loko o ke koko e loaʻa ana he 1-5 mau hola ma hope o ke kauā ʻana.

ʻO ka nakinaki ʻana i ka protein protein o ka hydrochlorothiazide ma 64%.

ʻAʻole i hoʻohālikelike ʻia ka Hydrochlorothiazide a hoʻonui koke i nā ʻōpū. T 1/2 mau hola 5-15.

Nā kūlana kūikawā

• 1 kōpō pākōlio losartan 100 mg hydrochlorothiazide 25 mg Mīwīwī: nā kīpē pregelatinized - 69.84 mg, cellulose microcrystalline - 175.4 mg, mole lactose lōmole - 126.26 mg, ka pākuʻi o ka magnesium - 3,5 mg. ʻO ka mana o ka membrane film: hypromellose - 10 mg, macrogol 4000 - 1 mg, dye quinoline yellow (E104) - 0.11 mg, titanium dioxide (E171) - 2.89 mg, talc - 1 mg. pākōlio losartan 100 mg hydrochlorothiazide 12,5 mg ʻO nā kumuwaiwai: nā māka pregelatinized, cellulose microcrystalline, lōmole lactose, magnesium stearate. Hōʻuluʻulu Shell: hypromellose, macrogol 4000, quinoline kūmole melemele (E104), titanium dioxide (E171), talc. pākōlio losartan 100 mg hydrochlorothiazide 25 mg ʻO nā mea kuahiwi: nā māka pregelatinized, cellulose microcrystalline, lactose monohala, magnesium stearate. Hōʻuluʻulu Shell: hypromellose, macrogol 4000, quinoline kūmole melemele (E104), titanium dioxide (E171), talc. potassium losartan 50 mg hydrochlorothiazide 12,5 mg ʻO nā mea kuʻuna: kano pregelatinized, kaila selolosa microcrystalline, lactose monohidate, magnesium stearate Shell komposisyon: hypromellose, macrogol 4000, quinoline kaila melemele (E104), titanium dioxide (E171), tal. pākōlio losartan 50 mg hydrochlorothiazide 12,5 mg ʻO nā mea kuʻina: ka huakaʻi pregelatinized, cellulose microcrystalline, lactose monohala, magnesium stearate. Hōʻuluʻulu Shell: hypromellose, macrogol 4000, quinoline kūmole melemele (E104), titanium dioxide (E171), talc.

Nā Lorista N contraindications

• Hypersensitivity a losartan, i nā lāʻau lapaʻau i loaʻa mai nā sulfonamides a me nā mea ʻē aʻe o ka lāʻau lapaʻau, anuria, pilikia ʻole o ka renal (ʻo ka creinine clearance (CC) ma mua o 30 ml / min.), Hyperkalemia, dehydration (me nā poʻe he nui o ka diuretics) lima momona hōʻeha, maʻi hipokalemia refractory, hapai, lactation, hypotension arterial, makahiki ma lalo o 18 makahiki (ʻaʻole i hoʻokō ʻia ka hopena a me ka palekana), hemahema lactase, galactosemia a glucose / gal malabsorption syndrome Nā loina. Me ka mālama akahele: nā hana hoʻoliʻiliʻi o ka wai-electrolyte (hyponatremia, hypochloremic alkalosis, hypomagnesemia, hypokalemia), bilateral renal aren stenosis a i ʻole ka stenosis o hoʻokahi artery kidney, diabetes mellitus, hypercalcemia, hyperuricemia a / a i ʻole gout, i hoʻopili ʻia me kekahi anemone neurologicalal. hoʻomohala ʻia ma mua me nā lāʻau ʻē aʻe, me nā papa pale AP

Nā hopena ʻaoʻao Lorista N

• Ma ka ʻāpana o ke koko a me ka ʻōnaehana lymphatic: pinepine: anemia, Shenlane-Genokha purpura. Mai ka pānaʻi ʻana: ʻaʻole i loaʻa: nā hopena anaphylactic, angioedema (me ka uhi ʻana o ka larynx a me ka alelo, e hoʻolalelale ana i nā ala mokulele a me / a ke ʻano ʻana o ka maka, nā lehelehe, pharynx) Mai ka ʻaoʻao o ka pūnaehana nīkini waena a me nā ʻōnaehana hoʻoneʻe peripheral: mau pinepine: ka ʻeha, ka ʻōhumu a me ka hina ʻole systemic, ʻūhā, nā luhi, ka manawa maʻamau: migraine. Mai ke ʻano o ka pūnaʻi cardiovascular: pinepine: hypotension orthostatic (hilinaʻi-dosis), palpitations, tachycardia, ʻaʻole anuʻu: vasculitis. Mai ka papa hana hanu: pinepine: mauʻu, ʻihi ʻana o nā ʻōpū hanu kiʻekiʻe, ʻo ka pharyngitis, ka huehue o ka mucosa nasal. Mai ka ʻeha gastrointestinal: pinepine: nā maʻi o ka maʻi, nā dyspepsia, nausea, ka luaʻi, ka ʻeha o ka ʻōpū. Mai ka ʻōnaehana hepatobiliary: loaʻa pinepine: hepatitis, hana hana kōpaʻa hemahema. Mai ka ʻili a me ka momona o ke kūpaʻa: pinepine: urticaria, ʻeha ka ʻili o ka ʻili. Mai ka ʻōnaehana musculoskeletal a me ka hoʻopili hoʻohui: pinepine: myalgia, ʻeha ʻeha, pinepine pinepine: arthralgia. Nā mea ʻē aʻe: ka pinepine: asthenia, nāwaliwali, edema peripheral, ʻeha ʻeha. Nā hōʻailona mākaʻina: pinepine: hyperkalemia, hoʻonui ʻia o ka hemoglobin a me ka hematocrit (ʻaʻole i koʻikoʻi i loko), pinepine: hoʻonui nui ʻana i ka serum urea a me nā mea hana, maʻa pinepine loa: hoʻonui i ka hana o ka ate a me nā enzyir bilirubin.

Nā kūlana mālama

• hale kūʻai ma ka lumi lumi 15-25 kiʻekiʻe
• haʻalele i nā keiki

I kēlā me kēia makahiki, ʻoi aku ka nui o nā poʻe e loaʻa i ka hoʻomohala ʻana i nā maʻi cardiovascular. Wahi a nā helu helu, i kēia manawa, ʻo nā keiki liʻiliʻi hoʻi ua alo i kēia pilikia. I kēia mau lā, he nui nā lāʻau lapaʻau e kōkua i ka hoʻouka kaua ʻana i ka maʻi o ka hypertension. ʻO kekahi o ka mea e pono ai, ʻo ia ʻo Lorista N.

ʻO Lorista N kahi hui pūnaehana e loaʻa ai ka hopena hypotensive. Hoʻomoʻa nā mea i loko o kāna palapala i ke koko koko a kōkua i ka hoʻopau ʻana i ka hana o ka naʻau. ʻO ka hopena maikaʻi o nā papa e hōʻoia ʻia e ka mea hana koʻikoʻi koʻikoʻi -. Ua hoʻonāukiuki ʻo ia i ka hoʻopaʻa ʻana o nā ʻāpana o ka ʻāwili i ka naʻau, nā kīʻaha koko a me nā pōpoki. I ka hopena o kēia, ua ʻike ʻia kahi emi o ka vasoconstriction.

ʻAʻole i like ʻo Lorista

I loko o nā lāʻau māmā Lūkini, kūʻai kekahi mau huahana like ʻole - Lorista N a ʻike ʻole ka nui o ka ʻike ʻole i ka hopena o waena o lākou.

ʻO ka ʻokoʻa nui ka māhele o nā lāʻau lapaʻau. Ma Lorista, ʻo losartan ka mea hana nui. Hoʻohana ʻia ka hana o nā mea hoʻohui aʻe e ka: starch corn, cellactose, magnesium stearate.

I kahi hoʻonui i hoʻonui ʻia ai kēia lāʻau me ka prefix H, ua hoʻohui ʻia ka papa inoa i ka hydrochlorothiazide. Kōkua ia i ka hōʻemi ʻana iā Na + ma ka pae o ka mahele cabsical reabsorption. ʻAʻole hoʻi pono e koho unahi i kēlā me kēia no ka maʻi mua o nā poʻe maʻi.

ʻO kekahi ʻano ʻē aʻe ma waena o kēia mau lāʻau he kumu. Ua emi iki ka awelika o Lorista a emi i 100-130 mau rubles. ʻO ka hana o nā hana, ʻelua nā lāʻau lapaʻau e kōkua i ke kahe koko.

Kūmole a manaʻo ʻia ke kumukūʻai o ka lāʻau

Loaʻa ka lāʻau lapaʻau i ke ʻano o nā papa i loaʻa nā pulu melemele. I kekahi manawa aia nā papa kala ʻōmaʻomaʻo. He liʻiliʻi lākou i ka nui a me ka oval i ke ʻano, e hana ai ka ʻoluʻolu i hiki ke hiki. Ma kekahi ʻaoʻao kahi ʻāpana kaawale (Lorista ND, me ka nui o ka manaʻo o ka mea hana kaha, he nalo ia).

Ma hope o ka kau ʻana i ka nānā ʻana a kūkākūkā ʻana me kahi loea, hiki i ka mea maʻi ke hoʻomaopopo i ka mea i ʻoi aku ka maikaʻi ma kāna hihia kūikawā - N a i ʻole ND. ʻAʻole pono ke kuhikuhi i ka mālama ʻana iā ʻoe iho, i ʻole e hōʻino i ke kino. ʻO ka kumu kumukūʻai he 230 rubles.

Ka hoʻokūkū, ka hana o nā hana a me nā ʻano

Hoʻopili ʻia kēlā me kēia papa me ka pālolo: losartan potassium (50 mg), hydrochlorothiazide (12.5 mg), ka waeʻa palaoa pregelatinized, MCC, magnesium stearate a lactose monohala. No laila, loaʻa nā papa me ke ʻano o ka nui o nā mea a losartan (100 mg). Ua kapa ʻia lākou iā Lorista ND. ʻO 25 mg o ka hydrochlorodisiad i hoʻohui ʻia i kā lākou hui. Ua like mau nā lālā kōkua.

No ka hana ʻana i kahi uhi kiʻiʻoniʻoni, hoʻohana nā mea hana i ka talc, ka melemele iʻa, E 171 (titanium dioxide), hypromellose, macrogol 4000.

ʻO ka hana o ka hana o nā hana ikaika nā mea e hōʻemi ai i ke koko a hōʻemi ma hope o ka hopohopo ma ka puʻuwai. Hoʻokomo nā mea i nā papa i ka hoʻonui ʻana i ka hana ʻo renin plasma, he hōʻemi i ka hoʻohuihui serum a me kahi hoʻomaikaʻi ʻana i ka ʻōlelo huna aldosterone.

Hoʻohālikelike ʻia ka mea nui o ka lāʻau e ka hana uricosuric. Hoʻopili ia i nā hopena physiological o ka angiotensin II. Me ka hydrochlorothiazide, hoʻohaʻahaʻa ka waiwai i ka hyperuricemia. ʻAʻole pili ka lāʻau lapaʻau i ka pinepine o nā hopena o nā ʻōpū o ka naʻau. Hoʻopilikia ʻia ka hopena antihypertensive e ka hoʻonui ʻia ʻana o nā wahī. Ma hope o nā hola 2-3, e loaʻa kahi hopena no kahi lā.

Hoʻopili pololei ʻia ʻo Losartan mai ka ʻeha gastrointestinal, ʻo ka pae bioavailability 32-33%. Hoʻopili ka mea i nā protein plasma. Ma kahi o 58% o ka lāʻau lapaʻau ka hoʻopā ʻia mai ke kino me ka hua bile, a ua 35% ka mea i hoʻopā ʻia e nā keiki. Ma hope o ka nānā ʻana, ua hoʻopili ʻia ka hydrochlorothiazide me nā protein plasma (ma kahi o 65%). I loko o 5-10 mau hola mai waho o ke kino me ka urine.

Nā hōʻailona a me nā palena

Ke hana nei ka lāʻau lapaʻau e like me kekahi o nā mea hoʻohui i ka hopena paʻakikī i ka loaʻa ʻana o ka hypertension arterial. Hōʻike pū kekahi mau hōʻailona:

1. ʻO ka hōʻemi ʻana i ka hopena o ka hoʻomohalaʻana i nā pathologies vascular a me cardiac.
2. ʻO ka hoʻopauʻana i nā hōʻailona leʻaleʻa me ka hypertrophy left ventricular.

Kalai hypertrophy hema

Manaʻo Lorista N i kahi mau contraindications, pono e mālama nui ma mua o ka lawe ʻana:

• huehue
• ka nele o ka lactose i ke kino,
• anuria
• nā mālamalama maikaʻi ʻole
• haʻahaʻa mau koko
• hapai
• intolerance pilikino a hypersensitivity paha i nā ʻāpana.

Eia nō hoʻi, ʻaʻole i kuhikuhi ʻia ka lāʻau lapaʻau no nā keiki ma lalo o ka makahiki 18. Me ka gout, diabetes, asthma, nā maʻi koko, ʻae ʻia ka lāʻau lapaʻau, akā ma lalo o ka mākaʻikaʻi koʻikoʻi o ke kauka.

Hiki i ka lāʻau lapaʻau iho ke hoʻonāukiuki i ke kūlana. Ma mua o ka lawe ʻana i ka lāʻau lapaʻau, pono ʻoe e ʻike i ke ʻano o ka neʻe ʻana.

Nā ʻōkuhi no ka hoʻohana

Pono ʻia ka lāʻau i mea hoʻokele waha, me ka manaʻo ʻole o ka meaʻai. Kūkulu ʻia kahi kōpae paʻakikī me nā lāʻau lapaʻau e hoʻohaʻahaʻa i ke koko. Hoʻokumu ʻia ka Dosis ma ke ʻano o nā patologi.

Wahi a nā ʻōkuhi no ka hoʻohana, me ka hypertension arterial i kēlā me kēia lā, ʻae ʻia ka lawe ʻana i 1 papa. ʻO ka palena nui he 2 pcs. Kuhi ʻia ka pono e hoʻonui i ke ʻano e ke kauka hele.

Ma ka hoʻokau ʻana i ka hypertrophy kiwa hema, ʻo ke ʻano o ka lā mua ma mua o 50 mg, ʻo ia hoʻi, 1 papa. I ke kakahiaka a i ke ahiahi paha - ʻaʻole ia he mea koʻikoʻi.

Ua makemake nui nā mea maʻi e inu paha i ka lāʻau lapaʻau no ke ola a i ʻole. I mea e hoʻomaʻamaʻa ai ke koʻikoʻi a me nā hōʻailona o ka maʻi, e pono ke hoʻopau i ka papa holoʻokoʻa (ma kahi o 30 mau lā). Ma hope o kēlā, e hana ana i ke kauka hele i kahi hoʻokolokolo hou aʻe a hōʻike i nā hana hou aʻe. Me ka hoʻouka hou ʻana, pono ʻoe e hele hou i ka papa.

He mea nui e noʻonoʻo i ka launa pū ʻana o ka lāʻau.

Nā hopena ʻaoʻao a me ka overdose

Inā lawe maikaʻi ʻia ka lāʻau lapaʻau, hiki mai nā hopena kūpono ʻole (Papa 2).

Eia kekahi laʻa, hiki i nā hopena ʻaoʻao ke loaʻa i ke ʻano o nā rashes i kūlohelohe i ka ʻili, ka mea i hui pū ʻia e ka minamina. Ma kahi o ka overdose, ua ahonui ka:

• kekahiki o bradycardia / tachycardia,
• ka hoemi nui ʻana i ke kahe koko,
• hyponatremia,
• hypochloremia.

Inā ʻike ʻia nā hōʻailona mua o ka overdose, pono ia e nīnau i ka loea. ʻO ke kōkua mua i kēlā mau hihia, ʻo ka gastage lavage. Eia kekahi, pono ka mea maʻi e loaʻa ka maʻi hōʻailona maʻi.

No ka mālama ʻia ʻana o nā maʻi cardiovascular, me ke kiʻekiʻe o ke koko, ua hoʻohana ʻia nō hoʻi nā mea hoʻohana o Lorista N. I ka hapa nui, hiki mai kēia pono pili me ka intolerance pilikino o kekahi mau ʻāpana.

Eia kekahi, ʻoi aku ka uku o kekahi mau analogues a ʻo Lorista N. ʻO ka papa inoa o nā lāʻau lapaʻau me kahi ʻano hana e like me ka hana:

1. Co-Centor (50 mg). He kumukūʻai ke 130 mau rubles.
2. (Nu. 30). Hiki ke kūʻai aku i ka lāʻau lapaʻau no 100-110 mau rubles.
3. Lozap 100 Plus (250 rubles).
4. Simartan-N.

Ma mua o ke kau ʻana i kahi lāʻau lapaʻau i kauoha ʻia e ke kauka, pono ia e kamaʻilio me ia, i ʻole e hoʻonāukiuki i ka hopena o nā ʻōpiopio.

ʻO ka hui a me ke ʻano o ka lāʻau lapaʻau

Nā papa hana ʻulaʻī mai ka melemele a me ka melemele me kahi hāmi ʻōmaʻomaʻo, oval, ka liʻiliʻi o ka biconvex, me ka loaʻa ʻana o ka ʻaoʻao ma ke ʻano, ʻo ke ʻano o ka papa ma ke ʻāpana ʻāpana ke kumu o ka papa keʻokeʻo.

Nā mea hoʻihoʻi: nā kīʻaha pregelatinized - 34.92 mg, cellulose microcrystalline - 87.7 mg, lōpose lactose - 63.13 mg, magnesium stearate - 1.75 mg.

ʻO ka hoʻonohonoho ʻana o ka ʻāpana film: hypromellose - 5 mg, macrogol 4000 - 0,5 mg, dye quinoline yellow (E104) - 0.11 mg, titanium dioxide (E171) - 1.39 mg, talc - 0,5 mg.

10 kamepiula - blisters (3) - nā ʻeke pepa.
10 kamepiula - nā kāmele (6) - nā kīwaha o ke kāleka.
10 kamepiula - nā kāmele (9) - nā kīʻaha o ke kāleka.

Ka hana lāʻau lapaʻau

Ka hana lāʻau lapaʻau - hypotensive .

Lapaʻau lāʻau

ʻO Lorista ® N - kahi lāʻau hui hoʻohui, loaʻa kahi hopena hypotensive.

Losartan. ʻO ka antagonist e pili ana i ka angiotensin II (type AT 1) no ka hoʻokūkū waha, ʻaʻohe ʻano o ka protein. Ke vivo a i loko o vitro losartan a me kāna hana olaiola e hiki ai i ka pākeke (EXP-3174) e kāohi i nā hopena koʻikoʻi a ka physiologically nui o ka angiotensin II ma ka ʻĀpana AT 1.

Hoʻololi ʻo Losartan i ka hana ʻana i nā mea hoʻoponopono o ka AT 2 e ka hoʻonui ʻana i ka pae o ka angiotensin II.

ʻAʻole ʻo Losartan i kāohi i ka hana o ka kininase II, he enzyme e pili ana i ka metabolism o ka bradykinin.

Hoʻēmi i ka OPSS, ka hoʻokaumaha ʻia i ke kahe ʻo ka "liʻiliʻi" o ke kahe o ke koko, e hōʻemi ana ma hope o ke kaumaha, he hopena diuretic.

Kūleʻa ʻia me ka hoʻomohala ʻana o ka hypertrophy myocardial, hoʻonui i ka hoʻolahalaha ʻana i nā maʻi me nā maʻi ʻoi ʻole ka maʻi. ʻO ka lawe ʻana i ka losartan i kahi lā e alakaʻi i ka emi ʻana o ka helu nui ma SBP a me DBP. Ka ʻoluʻolu i ka wailele o Losartan ma ke ao, aʻo ka hopena antihypertensive e pili i ka ʻenikani circadian kūlohelohe. ʻO ka emi o ke kahe o ke koko i ka hopena o ka hopena o ka lāʻau lapaʻau ma kahi o 70-80% o ka hopena i ka hopena o ka lāʻau, 5-6 mau hola ma hope o ke lawelawe ʻana. ʻAʻole mālama ʻia ka maʻi kahalike, a ʻaʻohe o ka losartan i ka hopena koʻikoʻi ma o ka puʻuwai puʻuwai.

Maikaʻi ʻo Losartan i nā kāne a me nā wahine, ʻoiai ʻo ia i nā ʻelemakule (ma mua o 65 mau makahiki) a me nā mea maʻi (ma lalo o 65 mau makahiki).

ʻO ka hole waiwai. A diuretic thiazide, ka hopena diuretic e pili ana me ka reabsorption impaired o ka sodium, chlorine, potassium, magnesium, wai i loko o ka nealron mamao, nā mea hoʻokaʻawale i nā excretion o nā ions calcium, uric acid. He mau waiwai antihypertensive. ʻAʻohe hopena i kahi kahe koko maʻamau.

Hoʻolaha ka hopena diuretic ma hope o nā hola 1-2, hiki i ka lōʻihi ma hope o 4 mau hola a lōʻihi i nā hola 6-12. ʻO ka hopena antihypertensive e hele mai ma hope o nā lā 3-4, akā hiki paha i nā 3-4 mau wiki e hoʻokō ai i ka hopena therapeutic hopena.

Nā Hoʻohui

Hypersensitivity a losartan, i nā huahana i loaʻa mai nā sulfonamides a me nā mea ʻē aʻe o ka lāʻau lapaʻau, anuria, pilikia hōʻeha kino (Cl creatinine 65 mau makahiki) a me nā mea maʻi (

Lapaʻau lāʻau

Nā kūlana kūikawā

• 1 kōpō pākōlio losartan 100 mg hydrochlorothiazide 25 mg Mīwīwī: nā kīpē pregelatinized - 69.84 mg, cellulose microcrystalline - 175.4 mg, mole lactose lōmole - 126.26 mg, ka pākuʻi o ka magnesium - 3,5 mg. ʻO ka mana o ka membrane film: hypromellose - 10 mg, macrogol 4000 - 1 mg, dye quinoline yellow (E104) - 0.11 mg, titanium dioxide (E171) - 2.89 mg, talc - 1 mg. pākōlio losartan 100 mg hydrochlorothiazide 12,5 mg ʻO nā kumuwaiwai: nā māka pregelatinized, cellulose microcrystalline, lōmole lactose, magnesium stearate. Hōʻuluʻulu Shell: hypromellose, macrogol 4000, quinoline kūmole melemele (E104), titanium dioxide (E171), talc. pākōlio losartan 100 mg hydrochlorothiazide 25 mg ʻO nā mea kuahiwi: nā māka pregelatinized, cellulose microcrystalline, lactose monohala, magnesium stearate. Hōʻuluʻulu Shell: hypromellose, macrogol 4000, quinoline kūmole melemele (E104), titanium dioxide (E171), talc. potassium losartan 50 mg hydrochlorothiazide 12,5 mg ʻO nā mea kuʻuna: kano pregelatinized, kaila selolosa microcrystalline, lactose monohidate, magnesium stearate Shell komposisyon: hypromellose, macrogol 4000, quinoline kaila melemele (E104), titanium dioxide (E171), tal. pākōlio losartan 50 mg hydrochlorothiazide 12,5 mg ʻO nā mea kuʻina: ka huakaʻi pregelatinized, cellulose microcrystalline, lactose monohala, magnesium stearate. Hōʻuluʻulu Shell: hypromellose, macrogol 4000, quinoline kūmole melemele (E104), titanium dioxide (E171), talc.

Nā Manaʻo Lorista N

• * Hypertension arterial (i nā poʻe maʻi e hōʻike ʻia ana ka hui hoʻohui). * ʻO ka hōʻemi o ka hopena o ka morbidity cardiovascular a me ka make ma ka poʻe maʻi me ka hypertension a waiho i ka hypricrophy ventricular.

Nā Lorista N contraindications

• Hypersensitivity a losartan, i nā lāʻau lapaʻau i loaʻa mai nā sulfonamides a me nā mea ʻē aʻe o ka lāʻau lapaʻau, anuria, pilikia ʻole o ka renal (ʻo ka creinine clearance (CC) ma mua o 30 ml / min.), Hyperkalemia, dehydration (me nā poʻe he nui o ka diuretics) lima momona hōʻeha, maʻi hipokalemia refractory, hapai, lactation, hypotension arterial, makahiki ma lalo o 18 makahiki (ʻaʻole i hoʻokō ʻia ka hopena a me ka palekana), hemahema lactase, galactosemia a glucose / gal malabsorption syndrome Nā loina. Me ka mālama akahele: nā hana hoʻoliʻiliʻi o ka wai-electrolyte (hyponatremia, hypochloremic alkalosis, hypomagnesemia, hypokalemia), bilateral renal aren stenosis a i ʻole ka stenosis o hoʻokahi artery kidney, diabetes mellitus, hypercalcemia, hyperuricemia a / a i ʻole gout, i hoʻopili ʻia me kekahi anemone neurologicalal. hoʻomohala ʻia ma mua me nā lāʻau ʻē aʻe, me nā papa pale AP

Lorista H dosage

• 100 mg + 25 mg 12.5 mg + 100 mg 12.5 mg + 50 mg 25 mg + 100 mg 25 mg + 100 mg 50 mg + 12.5 mg

Nā hopena ʻaoʻao Lorista N

• Ma ka ʻāpana o ke koko a me ka ʻōnaehana lymphatic: pinepine: anemia, Shenlane-Genokha purpura. Mai ka pānaʻi ʻana: ʻaʻole i loaʻa: nā hopena anaphylactic, angioedema (me ka uhi ʻana o ka larynx a me ka alelo, e hoʻolalelale ana i nā ala mokulele a me / a ke ʻano ʻana o ka maka, nā lehelehe, pharynx) Mai ka ʻaoʻao o ka pūnaehana nīkini waena a me nā ʻōnaehana hoʻoneʻe peripheral: mau pinepine: ka ʻeha, ka ʻōhumu a me ka hina ʻole systemic, ʻūhā, nā luhi, ka manawa maʻamau: migraine. Mai ke ʻano o ka pūnaʻi cardiovascular: pinepine: hypotension orthostatic (hilinaʻi-dosis), palpitations, tachycardia, ʻaʻole anuʻu: vasculitis. Mai ka papa hana hanu: pinepine: mauʻu, ʻihi ʻana o nā ʻōpū hanu kiʻekiʻe, ʻo ka pharyngitis, ka huehue o ka mucosa nasal. Mai ka ʻeha gastrointestinal: pinepine: nā maʻi o ka maʻi, nā dyspepsia, nausea, ka luaʻi, ka ʻeha o ka ʻōpū. Mai ka ʻōnaehana hepatobiliary: loaʻa pinepine: hepatitis, hana hana kōpaʻa hemahema. Mai ka ʻili a me ka momona o ke kūpaʻa: pinepine: urticaria, ʻeha ka ʻili o ka ʻili. Mai ka ʻōnaehana musculoskeletal a me ka hoʻopili hoʻohui: pinepine: myalgia, ʻeha ʻeha, pinepine pinepine: arthralgia. Nā mea ʻē aʻe: ka pinepine: asthenia, nāwaliwali, edema peripheral, ʻeha ʻeha. Nā hōʻailona mākaʻina: pinepine: hyperkalemia, hoʻonui ʻia o ka hemoglobin a me ka hematocrit (ʻaʻole i koʻikoʻi i loko), pinepine: hoʻonui nui ʻana i ka serum urea a me nā mea hana, maʻa pinepine loa: hoʻonui i ka hana o ka ate a me nā enzyir bilirubin.

Hoʻohui nūhou

Ke keu

Nā kūlana mālama

• hale kūʻai ma ka lumi lumi 15-25 kiʻekiʻe
• haʻalele i nā keiki

I kēlā me kēia makahiki, ʻoi aku ka nui o nā poʻe e loaʻa i ka hoʻomohala ʻana i nā maʻi cardiovascular. Wahi a nā helu helu, i kēia manawa, ʻo nā keiki liʻiliʻi hoʻi ua alo i kēia pilikia. I kēia mau lā, he nui nā lāʻau lapaʻau e kōkua i ka hoʻouka kaua ʻana i ka maʻi o ka hypertension. ʻO kekahi o ka mea e pono ai, ʻo ia ʻo Lorista N.

ʻO Lorista N kahi hui pūnaehana e loaʻa ai ka hopena hypotensive. Hoʻomoʻa nā mea i loko o kāna palapala i ke koko koko a kōkua i ka hoʻopau ʻana i ka hana o ka naʻau. ʻO ka hopena maikaʻi o nā papa e hōʻoia ʻia e ka mea hana koʻikoʻi koʻikoʻi -. Ua hoʻonāukiuki ʻo ia i ka hoʻopaʻa ʻana o nā ʻāpana o ka ʻāwili i ka naʻau, nā kīʻaha koko a me nā pōpoki. I ka hopena o kēia, ua ʻike ʻia kahi emi o ka vasoconstriction.

ʻAʻole i like ʻo Lorista

I loko o nā lāʻau māmā Lūkini, kūʻai kekahi mau huahana like ʻole - Lorista N a ʻike ʻole ka nui o ka ʻike ʻole i ka hopena o waena o lākou.

ʻO ka ʻokoʻa nui ka māhele o nā lāʻau lapaʻau. Ma Lorista, ʻo losartan ka mea hana nui. Hoʻohana ʻia ka hana o nā mea hoʻohui aʻe e ka: starch corn, cellactose, magnesium stearate.

I kahi hoʻonui i hoʻonui ʻia ai kēia lāʻau me ka prefix H, ua hoʻohui ʻia ka papa inoa i ka hydrochlorothiazide. Kōkua ia i ka hōʻemi ʻana iā Na + ma ka pae o ka mahele cabsical reabsorption. ʻAʻole hoʻi pono e koho unahi i kēlā me kēia no ka maʻi mua o nā poʻe maʻi.

ʻO kekahi ʻano ʻē aʻe ma waena o kēia mau lāʻau he kumu. Ua emi iki ka awelika o Lorista a emi i 100-130 mau rubles. ʻO ka hana o nā hana, ʻelua nā lāʻau lapaʻau e kōkua i ke kahe koko.

Kūmole a manaʻo ʻia ke kumukūʻai o ka lāʻau

Loaʻa ka lāʻau lapaʻau i ke ʻano o nā papa i loaʻa nā pulu melemele. I kekahi manawa aia nā papa kala ʻōmaʻomaʻo. He liʻiliʻi lākou i ka nui a me ka oval i ke ʻano, e hana ai ka ʻoluʻolu i hiki ke hiki. Ma kekahi ʻaoʻao kahi ʻāpana kaawale (Lorista ND, me ka nui o ka manaʻo o ka mea hana kaha, he nalo ia).

Ma hope o ka kau ʻana i ka nānā ʻana a kūkākūkā ʻana me kahi loea, hiki i ka mea maʻi ke hoʻomaopopo i ka mea i ʻoi aku ka maikaʻi ma kāna hihia kūikawā - N a i ʻole ND. ʻAʻole pono ke kuhikuhi i ka mālama ʻana iā ʻoe iho, i ʻole e hōʻino i ke kino. ʻO ka kumu kumukūʻai he 230 rubles.

Ka hoʻokūkū, ka hana o nā hana a me nā ʻano

Hoʻopili ʻia kēlā me kēia papa me ka pālolo: losartan potassium (50 mg), hydrochlorothiazide (12.5 mg), ka waeʻa palaoa pregelatinized, MCC, magnesium stearate a lactose monohala. No laila, loaʻa nā papa me ke ʻano o ka nui o nā mea a losartan (100 mg). Ua kapa ʻia lākou iā Lorista ND. ʻO 25 mg o ka hydrochlorodisiad i hoʻohui ʻia i kā lākou hui. Ua like mau nā lālā kōkua.

No ka hana ʻana i kahi uhi kiʻiʻoniʻoni, hoʻohana nā mea hana i ka talc, ka melemele iʻa, E 171 (titanium dioxide), hypromellose, macrogol 4000.

ʻO ka hana o ka hana o nā hana ikaika nā mea e hōʻemi ai i ke koko a hōʻemi ma hope o ka hopohopo ma ka puʻuwai. Hoʻokomo nā mea i nā papa i ka hoʻonui ʻana i ka hana ʻo renin plasma, he hōʻemi i ka hoʻohuihui serum a me kahi hoʻomaikaʻi ʻana i ka ʻōlelo huna aldosterone.

Hoʻohālikelike ʻia ka mea nui o ka lāʻau e ka hana uricosuric. Hoʻopili ia i nā hopena physiological o ka angiotensin II. Me ka hydrochlorothiazide, hoʻohaʻahaʻa ka waiwai i ka hyperuricemia. ʻAʻole pili ka lāʻau lapaʻau i ka pinepine o nā hopena o nā ʻōpū o ka naʻau. Hoʻopilikia ʻia ka hopena antihypertensive e ka hoʻonui ʻia ʻana o nā wahī. Ma hope o nā hola 2-3, e loaʻa kahi hopena no kahi lā.

Hoʻopili pololei ʻia ʻo Losartan mai ka ʻeha gastrointestinal, ʻo ka pae bioavailability 32-33%. Hoʻopili ka mea i nā protein plasma. Ma kahi o 58% o ka lāʻau lapaʻau ka hoʻopā ʻia mai ke kino me ka hua bile, a ua 35% ka mea i hoʻopā ʻia e nā keiki. Ma hope o ka nānā ʻana, ua hoʻopili ʻia ka hydrochlorothiazide me nā protein plasma (ma kahi o 65%). I loko o 5-10 mau hola mai waho o ke kino me ka urine.

Nā hōʻailona a me nā palena

Ke hana nei ka lāʻau lapaʻau e like me kekahi o nā mea hoʻohui i ka hopena paʻakikī i ka loaʻa ʻana o ka hypertension arterial. Hōʻike pū kekahi mau hōʻailona:

1. ʻO ka hōʻemi ʻana i ka hopena o ka hoʻomohalaʻana i nā pathologies vascular a me cardiac.
2. ʻO ka hoʻopauʻana i nā hōʻailona leʻaleʻa me ka hypertrophy left ventricular.

Kalai hypertrophy hema

Manaʻo Lorista N i kahi mau contraindications, pono e mālama nui ma mua o ka lawe ʻana:

• huehue
• ka nele o ka lactose i ke kino,
• anuria
• nā mālamalama maikaʻi ʻole
• haʻahaʻa mau koko
• hapai
• intolerance pilikino a hypersensitivity paha i nā ʻāpana.

Eia nō hoʻi, ʻaʻole i kuhikuhi ʻia ka lāʻau lapaʻau no nā keiki ma lalo o ka makahiki 18. Me ka gout, diabetes, asthma, nā maʻi koko, ʻae ʻia ka lāʻau lapaʻau, akā ma lalo o ka mākaʻikaʻi koʻikoʻi o ke kauka.

Hiki i ka lāʻau lapaʻau iho ke hoʻonāukiuki i ke kūlana. Ma mua o ka lawe ʻana i ka lāʻau lapaʻau, pono ʻoe e ʻike i ke ʻano o ka neʻe ʻana.

Nā ʻōkuhi no ka hoʻohana

Pono ʻia ka lāʻau i mea hoʻokele waha, me ka manaʻo ʻole o ka meaʻai. Kūkulu ʻia kahi kōpae paʻakikī me nā lāʻau lapaʻau e hoʻohaʻahaʻa i ke koko. Hoʻokumu ʻia ka Dosis ma ke ʻano o nā patologi.

Wahi a nā ʻōkuhi no ka hoʻohana, me ka hypertension arterial i kēlā me kēia lā, ʻae ʻia ka lawe ʻana i 1 papa. ʻO ka palena nui he 2 pcs. Kuhi ʻia ka pono e hoʻonui i ke ʻano e ke kauka hele.

Ma ka hoʻokau ʻana i ka hypertrophy kiwa hema, ʻo ke ʻano o ka lā mua ma mua o 50 mg, ʻo ia hoʻi, 1 papa. I ke kakahiaka a i ke ahiahi paha - ʻaʻole ia he mea koʻikoʻi.

Ua makemake nui nā mea maʻi e inu paha i ka lāʻau lapaʻau no ke ola a i ʻole. I mea e hoʻomaʻamaʻa ai ke koʻikoʻi a me nā hōʻailona o ka maʻi, e pono ke hoʻopau i ka papa holoʻokoʻa (ma kahi o 30 mau lā). Ma hope o kēlā, e hana ana i ke kauka hele i kahi hoʻokolokolo hou aʻe a hōʻike i nā hana hou aʻe. Me ka hoʻouka hou ʻana, pono ʻoe e hele hou i ka papa.

He mea nui e noʻonoʻo i ka launa pū ʻana o ka lāʻau.

Nā hopena ʻaoʻao a me ka overdose

Inā lawe maikaʻi ʻia ka lāʻau lapaʻau, hiki mai nā hopena kūpono ʻole (Papa 2).

Eia kekahi laʻa, hiki i nā hopena ʻaoʻao ke loaʻa i ke ʻano o nā rashes i kūlohelohe i ka ʻili, ka mea i hui pū ʻia e ka minamina. Ma kahi o ka overdose, ua ahonui ka:

• kekahiki o bradycardia / tachycardia,
• ka hoemi nui ʻana i ke kahe koko,
• hyponatremia,
• hypochloremia.

Inā ʻike ʻia nā hōʻailona mua o ka overdose, pono ia e nīnau i ka loea. ʻO ke kōkua mua i kēlā mau hihia, ʻo ka gastage lavage. Eia kekahi, pono ka mea maʻi e loaʻa ka maʻi hōʻailona maʻi.

No ka mālama ʻia ʻana o nā maʻi cardiovascular, me ke kiʻekiʻe o ke koko, ua hoʻohana ʻia nō hoʻi nā mea hoʻohana o Lorista N. I ka hapa nui, hiki mai kēia pono pili me ka intolerance pilikino o kekahi mau ʻāpana.

Eia kekahi, ʻoi aku ka uku o kekahi mau analogues a ʻo Lorista N. ʻO ka papa inoa o nā lāʻau lapaʻau me kahi ʻano hana e like me ka hana:

1. Co-Centor (50 mg). He kumukūʻai ke 130 mau rubles.
2. (Nu. 30). Hiki ke kūʻai aku i ka lāʻau lapaʻau no 100-110 mau rubles.
3. Lozap 100 Plus (250 rubles).
4. Simartan-N.

Ma mua o ke kau ʻana i kahi lāʻau lapaʻau i kauoha ʻia e ke kauka, pono ia e kamaʻilio me ia, i ʻole e hoʻonāukiuki i ka hopena o nā ʻōpiopio.

ʻO ka hui a me ke ʻano o ka lāʻau lapaʻau

Nā papa hana ʻulaʻī mai ka melemele a me ka melemele me kahi hāmi ʻōmaʻomaʻo, oval, ka liʻiliʻi o ka biconvex, me ka loaʻa ʻana o ka ʻaoʻao ma ke ʻano, ʻo ke ʻano o ka papa ma ke ʻāpana ʻāpana ke kumu o ka papa keʻokeʻo.

Nā mea hoʻihoʻi: nā kīʻaha pregelatinized - 34.92 mg, cellulose microcrystalline - 87.7 mg, lōpose lactose - 63.13 mg, magnesium stearate - 1.75 mg.

ʻO ka hoʻonohonoho ʻana o ka ʻāpana film: hypromellose - 5 mg, macrogol 4000 - 0,5 mg, dye quinoline yellow (E104) - 0.11 mg, titanium dioxide (E171) - 1.39 mg, talc - 0,5 mg.

10 kamepiula - blisters (3) - nā ʻeke pepa.
10 kamepiula - nā kāmele (6) - nā kīwaha o ke kāleka.
10 kamepiula - nā kāmele (9) - nā kīʻaha o ke kāleka.

Ka hana lāʻau lapaʻau

Hoʻohui hui antihypertensive ʻO Losartan a me hydrochlorothiazide he hopena hoʻohui antihypertensive, e hoʻohaʻahaʻa ana i ke kahe koko i kahi nui aʻe ma mua o nā hui āpau.

Losartan he antagonist koho a nā ʻāpana ʻāpana angiotensin II (type AT 1) no ka hoʻokō waha. In vivo and in vitro, losartan and its pharmacologically active metabolite E-3174 block all the physiologically significant effects of angiotensin II on AT 1 receptors, atena o ke ala o kāna synthesis: alakaʻi ia i ka hoʻonui o ka hana renin koko a me ka hoʻohaʻahaʻa ʻana i ka paʻa o ka ald testosterone i loko o ke koko koko. Hoʻololi ʻo Losartan i ka hana ʻana i nā mea hoʻoponopono o ka AT 2 e ka hoʻonui ʻana o ka neʻe o ka angiotensin II.ʻAʻole ia i pale i ka hana a kininase II, kahi enme e komo i ka metabolism o ka bradykinin. He hōʻemi ia i OPSS, kaomi i ke kaomi pulmonary, e hōʻemi ana i ka myocardial afterload, loaʻa kahi hopena diuretic. Kūleʻa ʻia me ka hoʻomohala ʻana o ka hypertrophy myocardial, hoʻonui i ka hoʻolahalaha ʻana i nā maʻi me nā maʻi ʻoi aku ka maʻi paʻakikī (CHF). ʻO ka lawe ʻana i ka losartan 1 ka manawa / lā alakaʻi i kahi nui statistically nui i ka systolic a me ka diastolic blood pressure.

Mālama ʻo Losartan i ke kahe o ke koko i ka wā o ka lā, ʻoiai ka hopena antihypertensive e pili ana i ka ʻenehana circadian kūlohelohe. ʻO ka emi ʻana o ke koko i ka hopena o ka hopena o ka lāʻau lapaʻau ma kahi o 70-80% o ka hopena kiʻekiʻe loa o losartan, 5-6 mau hola ma hope o ka nānā ʻana. ʻAʻohe mea pale maʻi.

ʻAʻohe o Losartan e hopena koʻikoʻi i ka puʻuwai pu, i ka hopena uricosuric a me ka transient.

ʻO ka hole waiwai- kahi diuretic thiazide, ka hopena diuretic e pili ana i ka hana hewa ʻana i ka reabsorption o ka sodium, chlorine, potassium, magnesium, ions wai ma ka distal nephron, e kāpae i nā mea i pau i nā kaluna o nā calcium, a me nā wai uric. Loaʻa ia he hopena antihypertensive, ka hana a ka mea e hoʻomohala ai ma muli o ka hoʻonuiʻia o ka arterioles. ʻAʻohe hopena i kahi kahe koko maʻamau. Hoʻolaha ka hopena diuretic ma hope o nā hola 1-2, hiki i ka lōʻihi ma hope o 4 mau hola a lōʻihi i nā hola 6-12. ʻO ka hopena antihypertensive ka hopena ma hope o nā lā 3-4, akā hiki paha i nā 3-4 mau pule e hoʻokō ai i ka hopena therapeutic hopena.

Ma muli o ka hopena diuretic, hoʻonui ka hydrochlorothiazide i ka hana o ka plasma renin, hoʻoulu i ka mea huna o ka ald testosterone, hoʻonui i ka ʻike o ka angiotensin II a hoʻoneʻe i ke kāohi o ka paʻakai i ka plasma koko. ʻO ka loaʻa ʻana o nā poloka losartan e pili ana i ka hopena o ke kino o ka angiotensin II a, ma muli o ke kaohi ʻana o nā hopena o ka aldosterone, hiki ke kōkua i ka hōʻemi o ka potoma e pili ana i ka lawe ʻana i kahi diuretic. Hiki i ka Hydrochlorothiazide ke hoʻonui iki i ka hoʻoliʻiliʻi o ka waikika uric i loko o ke koko, ka hui pū ʻana o losartan a me hydrochlorothiazide e kōkua i ka hōʻemi o ka nui o ka hyperuricemia i loaʻa e kahi diuretic.

Lapaʻau lāʻau

ʻO nā pharmacokinetics o losartan a me hydrochlorothiazide me ka hoʻohana like ʻole i ʻokoʻa ʻole i ko lākou hoʻohana ʻana me ka monotherapy.

Ma hope o ka lawelawe waha, ua maikaʻi maikaʻi ka losartan mai ka digestive tract. Hana ia i ka metabolism koʻikoʻi i ka "papa mua" ma o ka ate, e hana ana i ka carboxylated metabolite carboxylated metabolite (E-3174) a me nā metabolite ikaika ʻole. ʻO ka bioavailability e pili ana i ka 33%. ʻO ka awelika C max o losartan a me kāna metabolite hōʻino ua loaʻa ma hope o 1 hola a ma hope o nā hola 3-4, kēlā me kēia. ʻO Losartan a me kāna hana metabolite paʻa e hoʻopaʻa i nā protein plasma (ʻoi loa c) ma mua o 99%. ʻO V d o losartan he 34 lita. E komo pū ana i loko o ka BBB.

Hoʻololi ʻia ka Losartan e hana i kahi metabolite ikaika (E-3174) (14%) a i ʻole hana ʻole, me ka lua o nā metabolites nui i hoʻokumu ʻia e ka hydroxylation o nā pūʻulu butyl o ke kaulahao a me kahi metabolite liʻiliʻi liʻiliʻi, N-2-tetrazolglucuronide. ʻO ka wehe i ka plasma o ka losartan a me kāna metabolite hoʻoikaika e like me 10 ml / sec (600 ml / min) a me 0.83 ml / sec (50 ml / min), kēlā me ia. ʻO ka hoʻomaʻemaʻe ʻana i ka renal o ka losartan a me kāna metabolite hoʻoikaika e pili ana i ka 1.23 ml / sec (74 ml / min) a me 0.43 ml / sec (26 ml / min). T 1/2 o ka losartan a me ka metabolite ikaika e 2 mau hola a he 6-9 hola, ia wa. Hoʻopili ʻia ia me ka bile ma o ka ʻōpū - 58%, keiki - 35%. ʻAʻole hoʻoiho.

Ke lawe waha ʻia ma nā inika a hiki i ka 200 mg, losartan a me kāna hana metabolite i ka lineac pharmacokinetics.

Ma hope o ka lawelawe waha, ʻo ka hoʻokomo ʻana o ka hydrochlorothiazide, ʻo 60-80%. Loaʻa ka C max i loko o ke kaila koko he 1-5 hola ma hope o ka nānā ʻana. Hoʻohālikelike i nā protein plasma koko - 64%. Penetrates ma o ka paepae placental. Hoʻokahi ʻia ma ka umauma wai. ʻAʻole i hoʻohālikelike ʻia ka Hydrochlorothiazide a ua lawe wikiwiki ʻia e nā keiki. ʻO T 1/2 mau hola 5-15. Ma ka hapa iki o 61% o ka nui i lawe ʻia ma ka waha he 24 nane i hoʻololi ʻia i loko o 24 mau hola.

Hypertension arterial (i nā poʻe maʻi e hōʻike ʻia ana i ke ʻano hui lāʻau), hōʻemi ʻia ka hopena o ka morbidity cardiovascular a me ka make ma ka poʻe maʻi me ka hypertension arterial a waiho aku i ka hypertrophy ventricular.

Nā Hoʻohui

Anuria, pilikia hanalaha (CC