Kelepaʻi (Glipizide) > He hoʻomaʻemaʻe a me ke pale aku

Hoʻokumu i ka hoʻokuʻu ʻana o ka insulin mai nā hana beta pancreatic active functionally. E hōʻemi ana i ke kiʻekiʻe o ka hemoglobin glycosylated a me ka hoʻomehana ʻana i ka glucose o ka glucose i nā mea maʻi me nā maʻi maʻalahi a me nā maʻi koʻikoʻi o ka diabetes mellitus-non-insulin. Hoʻemi i ka hyperglycemia ma hope o ka meaʻai, hoʻonui i ka hoʻohaʻahaʻa glucose a me ka hoʻomaʻemaʻe ʻana i ke kahe manuahi (i kahi liʻiliʻi). Hoʻomoe ka pane insulinotropic i loko o 30 mau minuke ma hope o ka lawelawe ʻana i ka waha, ʻo ka lōʻihi o ka hana me ka pākahi hoʻokahi nō hiki i nā hola 24. ʻAʻole ia e pili i ke ʻano o ka lipid o ka plasma koko.

Ma nā hoʻokolohua ma luna o nā kaikahe a me nā kaole ma nā heʻe 75 mau manawa i ʻoi aku ai ma mua o MPD, ʻaʻole ia e hoʻonāukiuki i ka carcinogenesis a ʻaʻole i hoʻopilikia i ka huaʻai (mauʻu. Hana ʻia nā haʻawina i nā bacteria, a i vivo , ʻaʻole i hōʻike i nā waiwai mutagenic.

Hoʻohālikelike koke ʻia ka ʻano hana wikiwiki. ʻAʻole ʻai i ka ʻai i ka nui o ka hoʻopili ʻana, akā e hoʻolohi iā ia no 40 mau minuke. C_max hoʻoholo ʻia 1-3 mau hola ma hope o hoʻokahi pākahi. T_1/2 he mau hola he 2-4 18. Ma hope o ka lawe ʻana i ke ʻano hana lohi, ʻike ia i ke koko ma hope o nā hola 2-3, C_max Aia ia ma hope o nā hola 612. Aia ia i ka protein koko koko ma 98-199%. ʻO ka nui o ka hoʻoili ma hope o ka lawelawe ʻana iv he 11 L, awelika T_1/2 - Nā hola 2-5.ʻO ka huina Cl ma hope o ka manawa hope o ka iv he 3 l / h. ʻO Biotransformed i loko o ka palu (me ka hoʻomaka mua - ka liʻiliʻi). ʻOi aku ka emi o 10% i hoʻololi ʻia i ka urine a me nā kinikini, ma kahi o 90% e hoʻopiʻi ʻia ma ke ʻano o nā metabolites me ka urine (80%) a me nā feces (10%).

Nā hopena ʻaoʻao o ka waiwai Glipizide

No ka mea lohi o ka ʻano hana glipizide:

Mai ka pūnao a me ka hoʻonaninani naʻauao: ʻeha, hōʻeha, hōʻeha, lōkohu, hopohopo, ke kaumaha, hoʻomākeʻaka, huehue ka hoʻohālikelike, paresthesia, hypersthesia, pākui i mua o nā maka, ka ʻeha o ka maka, conjunctivitis, hemorrhage retinal.

Mai ka pūnaehana cardiovascular a me ke koko (hematopoiesis, hemostasis): syncope, arrhythmia, hypertension arterial, sensation of flashes wela.

Mai ka ʻaoʻao o ka metabolism: hypoglycemia.

Mai ka hāliʻi ʻana o ka huina: anorexia, nausea, luaʻi, ka manaʻo kaumaha i ka ʻāina epigastric, dyspepsia, constipation, he hoʻohui i ke koko i ka papa.

Ma ka ʻāpana o ka ʻili. ʻohi, urticaria, ʻeha.

Mai ka papa hana hanu: rhinitis, pharyngitis, dyspnea.

Mai ka pae genitourinary: dysuria, hoʻoemi i ka libido.

Nā ʻili: makewai, haʻalulu, edema peripheral, maʻi ʻole kūʻai i loko o ke kino holoʻokoʻa, arthralgia, myalgia, ʻūpeleka, hoʻopau loa ʻia.

No ka wikiwiki o ka hana o ka glipizide:

Mai ka pūnao a me ka hoʻonaninani naʻauao: hōʻeha, hōʻeha, ʻeha.

Mai ka pūnaehana cardiovascular a me ke koko (hematopoiesis, hemostasis: leukopenia, agranulocytosis, thrombocytopenia, pancytopenia, hemolytic a i ʻole aplastic anemia.

Mai ka ʻaoʻao o ka metabolism: maʻi maʻi maʻi indipidus, hyponatremia, maʻi maʻi phi.

Mai ka hāliʻi ʻana o ka huina: nausea, luaʻi, ʻeha ʻeha epigastric, constipation, hepatitis cholestatic (staining melemele o ka ʻili a me ka sclera, discoloration o ka ʻōpala a me nāʻeleʻele o ka urine, ʻehaʻeha i ka hypochondrium pololei).

Ma ka ʻāpana o ka ʻili. erythema, rash maculopapular, urticaria, photosensitivity.

Nā ʻili: hoʻonui i ke kūlike o ka LDH, ka phosphatase alkali, kūkaʻa bilirubin.

Hoʻohui

ʻO ka mineral a me nā glucocorticoids, amphetamines, anticonvulsants (hydantoin derivatives), asparaginase, baclofen, calcium antagonists, carbonic anhydrase inhibitors (acetazolamide), chlortalidone, oral contraceptives, epinephrine, ethacinic acid, giurimide, thymoside, thymegium nā hoʻonāʻau, triamteren a me nā lāʻau āpau e hoʻoiho i ka hyperglycemia. Hoʻokomo i nā steroid anabolic me androgens e hana i ka hana hypoglycemic. Pākuʻi i ka anticoagulants, NSAIDs, chloramphenicol, clofibrate, guanethidine, MAO inhibitors, probenecid, sulfonamides, rifampicin hoʻonui i ka uha o ka hapa kīʻaha i loko o ke koko (ma muli o ke kaʻe ʻana mai ka protein plasma) a hoʻomaikaʻi i ka biotransformation. Ketonazole, miconazole, sulfinpyrazone poloka kahe ole i ka hana a hoʻonui i ka hypoglycemia. E kū'ē i ke kua mua o ka waiʻona, hiki i ka uluʻana o kahi maʻi disulfiram-like (ʻeha o ka ʻōpū, hōʻeha, ka luaʻi, ke poʻo ʻeha. Hoʻonui ka lāʻau antithyroid a me myelotoxic i ka uluʻana o ka agranulocytosis, ke kau hope, i ka hoʻohui - thrombocytopenia.

Ke keu

Lāʻau: hoʻihoʻi i ka lāʻau, ke komo ʻana o glucose a me / a me ke hoʻololi ʻana i ka papaʻai me ka nānā ʻana i nā mākaʻi o ka glycemia, me ka hypoglycemia koʻikoʻi (coma, epileptiform seizure) - kahi hoʻokipa hoʻokipa, ka hoʻomalu ʻana i kahi hopena glucose intravenous 50% me ka infusion kekahi ʻO ka glucose e hōʻoia i ka kaohi ʻana o ke koko ma luna o 5.5 mmol / l, pono ka nānā ʻana o ka glycemia no 1-2 mau lā ma hope o ka mea maʻi e haʻalele i ka coma. ʻAʻohe kūpono ʻo Dialysis.

He kumukūʻai ma nā hale kūʻai

E nānā i ke kumukūʻai o Glipizide ma 2018 a me nā analogue maʻalahi >>> ʻO ke kumukūʻai o Glipizide ma nā lāʻau lapaʻau ʻē aʻe hiki ke loli ʻokoʻa. ʻO kēia ma muli o ka hoʻohana ʻana i nā ʻāpana haʻahaʻa a me ke kumu kūʻai kumukūʻai o ka paʻa pākana.

Heluhelu i ka ʻikepili mana e pili ana i ka lāʻau lapaʻau ʻo Glipizid, nā ʻōlelo aʻo no ka hoʻohana ʻana i ka ʻike i ka ʻike ʻokoʻa a me ka regimen mālama. Hāʻawi ʻia ia ʻia i ka ʻōlelo no ka ʻike ʻike a ʻaʻole hiki ke lawelawe ma ke ʻano o nā ʻōlelo aʻo.

Ka hana lāʻau lapaʻau

ʻO ka moliki hypoglycemic Oral, kahi derony o ka sulfonylurea o ka lua o ka hanauna. Hoʻāla i ka mea huna o ka insulin e nā β-cells o ka pancreas, hoʻonui i ka hoʻokuʻu i ka insulin. Hoʻonui i ka paʻakikī o nā kōpili peripheral i insulin. Loaʻa iā ia kahi hypolipidemic, ka hopena fibrinolytic, ke kāohi nei i ka pākuʻi platelet. Ma hope o ka hoʻopale waha, ka glipizide wikiwiki a piha i ka hoʻowalewale ʻana.
ʻO ka pilina ʻana i ka protein plasma (ʻo ka mea nui me ka albumin) he 98-99%.
Hoʻopili i ka puʻuwai. ʻOi aku ka emi ma 10% e hoʻopiʻi ʻia i loko o ka mimi a me nā feces i loli ʻole, ma kahi o 90% e hoʻopiʻi ʻia i ka urine (80%) a me nā feces (10%) like metabolites.

Ke ʻano o ka noi

No nā pākeke: Hoʻopili i kēlā me kēia kiʻi i ke kiʻi o ka maʻi maʻi. ʻO ka helu mua ma 2.5-5 mg 1 mau lā / lā 15-30 mau minuke ma mua o ka ʻaina kakahiaka. Inā kūpono, hiki i ke ʻano neʻe lohi (me kekahi mau manawa) i hoʻonui ʻia e 2.5-5 mg / lā. ʻO nā memona o kēlā me kēia lā i kahi o 15 mg e pono e hoʻokaʻawale i 2 mau pona.
Nā kaha kūoʻo: hoʻokahi - 15 mg, lā - 40 mg.

- Kūpono 2 diabetes mellitus (ʻaʻole-insulin-hilinaʻi) i nā mea maʻi me ka momona nui a i ke kino paha ma ke kino me kaʻai ʻole.

ʻO ka ʻike nui e pili ana i ka manaʻo

ʻO Glipizide ka inoa kālepa koʻikoʻi o ka lāʻau lapaʻau e loaʻa ana i ka waiwai o ka inoa like, akā he mea ia o nā lāʻau lapaʻau ʻē aʻe.

Hāʻawi ʻia ka māhele i ka hopena hypoglycemic i loaʻa, no ka mea i loaʻa i kona hopena ma nā ʻāpana pancreatic. ʻO ka hopena o kēia ka hana ikaika o ka insulin.

Hoʻohālikelike ʻia ke ʻano e nā pauma keʻokeʻo me ka ʻonanea ʻole i ʻōlelo ʻia. ʻAʻole ia i hoʻohālikelike ʻia e ka solubility i ka wai a i ʻole ka wai wai. Hoʻopili pinepine ka māhele me nā protein koko, i hoʻohuli ʻia i ka metabolites. Lawe ʻia ka ʻōkuhi e nā keiki.

Hoʻolālā ʻia ʻo Glipizide i nā papa me nā mea he nui e pili ana i ka 5 a me 10 mg. Hiki paha i nā mea kōkua i hilinaʻi ʻia ma ka inoa o ka lāʻau lapaʻau.

Nā hopena hopena

- Mai ka papahana endocrine: līkeke - hypoglycemia (ʻoi aku hoʻi i nā poʻe kahiko, nā nāwaliwali nāwaliwali, me ka ʻai maʻamau, inu i ka wai ʻaka, ʻoluʻolu a me ka hana ʻana o ka lolo).
- Mai ka papa hana o ka kūnaʻi: ka nausea, ka maʻi pākaha, loaʻa pinepine - hepatitis maʻi.
- Mai nā ʻōnaehana hemopoietic: i kekahi mau hihia - thrombocytopenia, leukopenia, agranulocytosis.
- Nā kūmole kūwaho: jarang - ʻili ka ʻili, kaʻeha.
- Nā ʻokoʻa ʻē aʻe.

Nā ʻōkuhi no ka hoʻohana

ʻO ka lāʻau ke manaʻo ʻia e hakakā i ke ʻano maʻi type 2, inā ʻaʻole ke ʻano lāʻau lapaʻau me ka hopena.

Lawe ʻia nā papa papaʻa, i ka manawa ma mua o ka papaʻaina, me ka lāʻau lapaʻau e holoi ʻia me ka wai. Hoʻokomo ʻia ka dosis ma ke ʻano o ka mea maʻi. Hoʻomaʻamaʻa pinepine ʻia e hoʻomaka me ka lawelawe ʻana o 5 mg i kēlā me kēia lā.

Me ka lawaʻole o ka maikaʻi a me ka hoʻomanawanui maikaʻi, hiki ke hoʻonui iki ʻia ka nui i 15 mg i kēlā me kēia lā. Hoʻouna ʻia ka lāʻau lapaʻau i ka manawa, hiki iā ʻoe ke hoʻokaʻawale i ka lawelawe ma kekahi mau ʻano.

I kekahi mau hihia, pono e hoʻemi ʻia ka hopena o Glipizide. No laila, ʻaʻole hoʻomaka e mālama i ka loaʻa ʻana o ka loiloi o ka loea - me ka ʻike olakino he paʻakikī loa ka loiloi ʻana i nā hiʻohiʻona o ke kiʻi lapaʻau.

He mea ʻaihue nā pilama huakaʻi, akā inā he mea e tupu ana, mai lawe i kahi pālua ʻelua.

ʻO nā maʻi a me nā hōʻeha

ʻOiai ʻo nā pono kūpono o kēia lāʻau lapaʻau no ka maʻi maʻi, aia nā pilikia inā pāpā ʻia kona hoʻohana ʻana.

ʻO nā contraindications nui o Glipizide ka mea:

nāna e hoʻowahāwahā i ka haku,
maʻi ketoacidosis maʻi
coma maʻi maʻi
hapai
ka hana kūlohelohe
maʻi diabetes type 1
hoʻōki kūloko
nā hōʻeha ʻeha
fiva.

ʻO ka pāpā i ka hoʻohana ʻana i ka lāʻau lapaʻau ka hopena i ka hopena o nā hopena kūpono ʻole e hiki mai.

I waena o lākou e ʻōlelo nei:

lie kanikela
āhāhuʻe
luhi, luhi
hiamoe
Hōʻike kaumaha
hilahila
hopohopo
konohiki
ʻeha ma nā maka
ʻūhū ʻia
nā kipi i ka digestive tract,
ninini
urticaria
pohuo
ʻili kino ʻili,
rhinitis
hoʻonui hoʻonui ikaika
ireliaia,
hoʻemi i ka libido
hoʻonui nui loa
hypoglycemia.

ʻAʻole pilikia ka nui o kēia mau hōʻino, akā e lawe mai i ka hōʻeha koʻikoʻi. Hiki i kekahi poʻe ke make i ka mea maʻi inā ʻaʻole i hāʻawi ʻia ka mālama olakino. No laila, ma mua o ka hoʻohana ʻana i nā lāʻau lapaʻau e pili ana i ka glipizide, pono e kamaʻilio aku ʻoe i kāu kauka a ʻike i ka pehea e lawe pono ai iā lākou. ʻOiai inā e hoʻohālikelike ʻia ka lāʻau e nā loea, pono ʻoe e kiaʻi pono i kou mālama pono. ʻO ka ʻike ʻana i nā pōʻino loa ke kumu e ʻimi ai i ke kōkua.

ʻAʻole hiki ke ʻae ʻia ka lāʻau lapaʻau i ka nīnau. Inā loaʻa nā contraindications, pono e kāhuli iā ia me kahi ʻē aʻe, me kahi ʻano like ʻole.

Ma waena o nā mea kikoʻī nui o Glipizide hiki ke kapa ʻia:

ʻO Glibenclamide. ^ E Ha yM. Hōʻike ʻia ka lāʻau lapaʻau e ka hopena hypoglycemic, ka mea i loaʻa ma muli o ke kiko o ka glipizide i loko. Ke hōʻike nei kēlā me Minidiab kahi kikoʻī piha o nā papa i noʻonoʻo ʻia i nā mea hoʻohālikelike, a he like kāna mau ʻōlelo aʻoaʻo. ʻO ka lāʻau lapaʻau kekahi o nā mea kumukūʻai; e uku ʻoe iā 1,500 rubles no ka hoʻopiha.
Metformin. ^ E Ha yM. ʻO kāna kumu kūpono o ka waiwai metformin. Kūleʻa ʻia ia me ka hana ikaika o ka glucose e ka ʻāʻī, a hoʻonui hoʻi i ka hoʻohuihui o nā ʻine i ka insulin. Ke kūʻai aku nei ka lāʻau lapaʻau i ke ʻano o nā papa me ke kumu kūʻai o 90-105 rubles.
Maninil. ^ E Ha yM. ʻO ke kumu o kēia lāʻau lapaʻau ka glibenclamide. E hoʻokuʻu a hoʻokuʻu ʻia kona hoʻokuʻu i ka palapala papa. Hoʻohui i ka hypoglycemic, he hopena cardioprotective a me ka antiarrhythmic hopena. Kūlike ke kumukūʻai mai 95 a 120 mau rubles.
Hoʻolaha. ^ E Ha yM. ʻO kāna kumu waiwai nui o ka metformin. Aia ka lāʻau i kahi papa papa, manaʻo ʻia no ka hoʻoponopono waha. Loaʻa iā ia kahi hopena hypoglycemic kiko. Kuhi ʻia lākou e like me ka hoʻolālā a ka loea ma kahi o 120 mau rubles.
Holaʻula. ^ E Ha yM. ʻO kēia kekahi mea hoʻohui hoʻohui hoʻohui me ka waiwai like. Hoʻololi ka hoʻonuiʻana i ka insulin i ke kino, a laila hoʻohaʻahaʻa i ka glucose koko. ʻO ke kumukūʻai e pili ana i 100-120 rubles.

Video mai ka loea.

ʻO kēia mau lāʻau āpau ke hōʻeha i nā hopena ʻaoʻao, ʻo ka mea sili loa ka weliweli aia ka hypoglycemia. Loaʻa iā lākou nā contraindications. No laila, pono ʻoe e hoʻohana iā lākou me ka ʻae ʻia o ke kauka a e like me ke kuhikuhi ʻana. ʻAʻole ʻae ʻia ke koho i kahi mea ku pono o ka lāʻau i kuhikuhi ʻia i kāu iho, hiki ke hōʻino.

E hoʻokuʻu i ke ʻano

Nā papa nui o ka 0.005 g (5 mg) i kahi kāʻei he 30 mau ʻāpana.

Hoʻokumu ʻia ka ʻikepili ma ka ʻaoʻao āu e nānā nei no nā pahuhopu ʻike a ʻaʻole ia e hoʻolaha i ka lāʻau lapaʻau ponoʻī ma kekahi ʻano. Pono ka punaewele e hoʻomaʻamaʻa i nā limahana mālama olakino me nā ʻike hou e pili ana i kekahi mau lāʻau lapaʻau, e hoʻonui ai i ko lākou pae kiʻekiʻe. Ke hoʻohana nei i ka lāʻau Hoʻolālā me ka nele o ka hoʻolako ʻana i kamaʻilio kūkākūkā me kahi loea, a me kāna mau ʻōlelo aʻoaʻo e pili ana i ke ʻano o ka hoʻohana a me ke ʻano o kāu lāʻau i koho ʻia.

ʻO ke kumukūʻai, nā loiloi a me nā hoʻohālike

ʻOiai ʻo ka glipizide kahi mea ikaika, nui nā lāʻau lapaʻau e loaʻa ana i kēlā ʻano mea e hiki ke loaʻa ma ka mākeke pharmacological o Rūsia. No ka hoʻohālikelike, Glucotrol CL a me Glibenez Retard. Mamuli o ka ʻano o ka hoʻokuʻu ʻana, ke kumukūʻai o ka lāʻau lapaʻau Glucotrol CL mai 280 a 360 rubles, a ʻo Glibenez Retard - mai 80 a 300 mau rubles.

Hōʻike ʻoluʻolu i ka hapanui o nā maʻi maʻi āpau i lawe i kēlā lāʻau lapaʻau. Eia nō naʻe, ua manaʻo ka nui i ka hopena o ka hopena o ka glipizide i ka manawa o ka manawa, no laila e hoʻohana pinepine ʻia i ka hui me nā lāʻau maʻi maʻi ʻē aʻe. Ma waena o nā pono o ka lāʻau lapaʻau hiki ke hoʻokaʻawale i ka maʻalahi o ka hoʻohana a me nā kumukūʻai kūpaʻa o nā lāʻau lapaʻau e pili ana i ka glipizide.

I ka hihia inā ʻaʻole kūpono kekahi lāʻau lapaʻau ma muli o nā contraindications a i ʻole nā hopena maikaʻiʻole, ua kuhikuhi ke kauka i kahi mea hoʻohālike. Aia kēia mau lāʻau lapaʻau:

Me ke ʻole o ka ʻae ʻana i kahi kauka, ʻaʻole pono ia nā lāʻau lapaʻau ponoʻī. ʻO ka hoʻomākaukau e pili ana i ka glipizide hiki i ka hopena maikaʻi loa ke kino o ke kanaka. Me ka hoʻohana pono o ka lāʻau lapaʻau, hiki iā ʻoe ke mālama i ka nui o ke kō ka wai maʻamau a haʻalele i nā hōʻailona o ka maʻi maʻi. Akā ʻaʻole naʻe hoʻi e poina iā mākou e pili ana i ka hoʻomaʻamaʻa kino no ka maʻi diabetes a me kaʻai kūpono.

I ke wikiō ma kēia ʻatikala, e kamaʻilio ke kauka e pili ana i nā lāʻau lapaʻau no ka maʻi maʻi.