Kaumakaiwa (Oxodoline)

Inoa inoa:Oxodoline

Ka hoʻonohonoho ʻana a me ke ʻano o ka hoʻokuʻu ʻana

Nā Palaki 1 papa i loaʻa iā 50 mg o ka chlortalidone.

I kahi pahu pā kuhi blister o 50 papa. Hoʻopili ʻia i kahi pahu pepa.

Nā ʻoihana ʻoihana ʻo ka ʻoihana kāohi me ka lāʻau lapaʻau

ʻĀpana Pharmacotherapeutic

ʻO ka hana lāʻau lapaʻau ma ka lāʻau Oxodolin

ʻO ka diuretic like-makemake ʻo Thiazide, he hopena lōʻihi. E hoʻonāukiuki i ka reabsorption o ka meium sodium, chlorine a me nā huina like ʻole o ka wai ma nā papa mamao o nā keiki. Eia kekahi, hoʻonui i ka excretion o ka pāhana paʻakai, magnesium, a me nā bicarbonate mai ke kino, e hoʻohemo i ka hōʻoki i ka waikiko uric, nā ions calcium. Nā poʻe aloha i ka diuretics o ka hana kūpono. Hoʻomaka ka hopena diuretic ma hope o 2 mau hola, hiki i kahi lōʻihi loa ma hope o 12 mau hola a lōʻihi a hiki i nā hola 72. Hoʻonohonoho kēia i nā kahe koko kiʻekiʻe. Hoʻololi maikaʻi ka hopena antihypertensive, e hōʻea i ka lōʻihi ma hope o 2 mau hebedoma. ma hope o ka hoʻomaka ʻana e mālama ʻia. Eia kekahi, hoʻonā ka chlortalidone i ka hōʻemi o ka polyuria i nā mea maʻi me ka maʻi insipidus maʻi, ʻoiai ʻaʻole i pau ka hoʻowali ʻana o kāna hana.

Lapaʻau lāʻau

Ma hope o ka lawelawe waha, ua hoʻoili ʻia ka chlortalidone mai ka papalapa ʻana. ʻAʻole mauʻuhea. Hoʻohālikelike ia i nā ʻāpana koko ʻulaʻula i kahi kiʻekiʻe, hoʻopaʻa ʻia i nā protein plasma he nui loa i ka haʻi.

T 1/2 lōʻihi, 40-60 hola.

Hoʻokuʻu ʻia ia ma ka ʻano maʻamau ʻole me ka urine.

I nā maʻi maʻi maʻi, ua lohi ka excretion, hoʻohālikelike ʻia me nā mea maʻi o nā ʻōpio a me nā makahiki waena, ʻaʻole i loli ka absorption.

II kahua CHF, hypertension arterial, ate cirrhosis me ka portal hypertension, nephrosis, nephritis, late gestosis (nephropathy, edema, eclampsia), hoʻomau ka wai ma ke kiʻi o ka premenstrual syndrome, insipidus diabetes, dysproteinemic edema, obesity.

Nā Hoʻohui

Hypersensitivity (me nā derivatives sulfonamide), hypokalemia, kaulike ʻole o ka renal (anuria), hepatic coma, hepatitis maʻa, maʻi mellitus (nā hana koʻikoʻi), gout, lactation. ʻO Renal a me / a me ka hāʻule ʻole o ka ate, nā hopena alia, bronchial asthma, SLE.

Dodage regimen a me ke ʻano o ka noi Oxodoline

E hoʻonohonoho hoʻokahi. Me ka hypertension arterial - 25 mg 1 manawa / lā. Inā makemake, hiki ke hoʻonui ʻia i ka momona i 50-100 mg / lā. Ma ka hōʻea i ka hopena, huli lākou i ka mālama mālama ʻia i ka hopena hoʻōla haʻahaʻa loa. Me ka maʻi edematous, kahi maʻi o 50-100 mg e hoʻohana ʻia i 1 mau manawa / lā, inā pono, a hiki i ka 200 mg, ma hope o ka hōʻea i ka hopena, huli lākou i ka hana mālama mālama.

Nā hopena hopena

Mai ka pūnaehana hana ʻana: hiki paha ke kala ʻana, ka luaʻi, ke ʻōpala, ka constipation, ka nalo ʻana o ka ʻono.

Mai ka ʻaoʻao o ka ʻōnaehana hoʻonāukiuki a me ka ʻōnaehana hoʻāʻo o peripheral: headache, nawaliwali, paresthesia, dizziness hiki.

Mai ka kaulike wai-electrolyte: hypokalemia, hypomagnesemia, hyponatremia, alkalosis hypochloremic, hypercalcemia ʻoluʻolu.

Mai ka ʻaoʻao o ka metabolism: kemungkinan hyperuricemia, hyperglycemia.

Mai ka ʻōnaehana hemopoietic: līpoki - thrombocytopenia, leukopenia.

Nā hopena dermatological: ʻili hiki ka ʻili.

ʻŌpū a me ka lactation

Penetrates ma o ka paepae placental. I ka wā hapai, contraindicated ma ka maʻi hypertension arterial. I nā hanana ʻē aʻe, hiki ke hoʻohana wale ʻia ma lalo o nā hōʻike koʻikoʻi i ka hopena liʻiliʻi loa a inā loaʻa ka hopena i manaʻo ʻia no ka hopena no ka makuahine e ʻoi aku ai ka hopena o ka wahine maʻi.

Hoʻopili ʻia ʻo Chlortalidone ma ka umauma umauma. Inā pono, e hoʻohana i ka wā o ka lactation, ʻo ka hōʻuluʻulu ʻana o ka waʻa e hoʻopau ʻia.

Ke noi no ka hana 'aho ka nānā nānā Contraindicated ma ka palaleka o ka nui o ka hana. E hoʻohana me ka mālama akahele i nā hihia o ka hana renal excretory hana.

Hoʻohana i nā mea maʻi maʻi

E hoʻohana me ka akahele o ka pākeke.

Nā ʻōlelo kikoʻī kūikawā no ke komo ʻana Oxodoline

I ka wā mālama, pono ia no ke kau ʻana i kēlā me kēia mau electrolytes i ke koko, ʻoi loa i nā mea maʻi e lawe nei i nā mākaukau digitalis. ʻAʻole ia e kuhikuhi i ke kuhikuhi i kahi meaʻai paʻakai koʻikoʻi ma ka mea maʻi. Inā aia nā hōʻailona o ka hypokalemia (myasthenia gravis, ʻehaʻeha ka huhū) a inā he maʻi hou ʻia ka nui o K + o ka make (me ka hoʻomoʻi ʻana, ka ʻeha ʻana, ka maʻi palaka, cirrhosis, hyperaldosteronism, ACTH therapy, GCS), ʻo ka hoʻōla ʻana me ka lāʻau o K + i hōʻike ʻia. I nā mea maʻi me ka hyperlipidemia, pono e kiaʻi mau ʻia nā lipolima (inā hoʻonui ko lākou koʻikoʻi, pono e hoʻokuʻu ʻia ka lāʻau). Me nā diuretics thiazide, ʻike ʻia kahi exacerbation o SLE. ʻOiai ʻaʻole i ʻike ʻia kēlā mau ʻano ʻano me chlortalidone, e hoʻomaʻemaʻe ʻia i ka wā e kuhikuhi ana i nā maʻi i ka SLE.

Nā pilina pili me nā lāʻau lapaʻau ʻē aʻe

Me ka hoʻohana pū ʻana me corticosteroids, amphotericin B, carbenoxolone, ke piʻi aʻe o ka hoʻoulu ʻana i ka hypokalemia koʻikoʻi.

Me ka hoʻohana like ʻana me NSAIDs, hiki ke loaʻa ka hopena o ka hopena o ka diuretic a me nā antihypertensive hopena o ka chlortalidone.

Me ka hoʻohana pū ʻana o ka hoʻomākaukau digitalis, hiki ke hoʻonui ʻia i ka ʻā o nā hopena ʻā o nā digitalis hoʻomākaukau ma muli o ka hypokalemia ma muli o ka hana o ka chlortalidone.

Me ka hana like o ka lithium carbonate, ʻo ke kahe o ka lithium i loko o ke kaila koko a me ka hiki i ka hoʻonui ʻana o ka lithium intoxication.

ʻO ka hoʻohana ʻana i ka lāʻau Oxodolin wale nō e like me ka mea i kuhikuhi ʻia e ke kauka, ua hāʻawi ʻia ka wehewehe no ke kuhikuhi!

He aha nā hōʻailona e hoʻomaopopo ai e hoʻomohala kahi kanaka i ka maʻi noʻonoʻo?

Lapaʻau lāʻau

Ma hope o ka lawelawe waha, ua hoʻoili ʻia ka chlortalidone mai ka papalapa ʻana. ʻAʻole mauʻuhea. Hoʻohālikelike ia i nā ʻāpana koko ʻulaʻula i kahi kiʻekiʻe, hoʻopaʻa ʻia i nā protein plasma he nui loa i ka haʻi.

T 1/2 lōʻihi, 40-60 hola.

Hoʻokuʻu ʻia ia ma ka ʻano maʻamau ʻole me ka urine.

I nā maʻi maʻi maʻi, ua lohi ka excretion, hoʻohālikelike ʻia me nā mea maʻi o nā ʻōpio a me nā makahiki waena, ʻaʻole i loli ka absorption.

Hōʻikeʻike i nā lāʻau lapaʻau

Loaʻa ka hopena

Mai ka pūnaehana hana ʻana: mual, ka luaʻi ʻana, ka ʻeha ʻana, ka constipation, ka hala ʻana o ka momona makemake.

Mai ka ʻaoʻao o ka pūnaehana nīkini waena a me nā ʻōnaehana pīpopipeka: headache, nawaliwali, paresthesia, dizziness ka mea hiki.

Ma ka ʻāpana o ka kaulike wai-electrolyte: hypokalemia, hypomagnesemia, hyponatremia, hypochloremic alkalosis, ʻo ka maʻi hypercalcemia.

Mai ka ʻaoʻao o ka metabolism: hiki i ka hyperuricemia, hyperglycemia.

Mai ka ʻōnaehana hemopoietic: luhi - thrombocytopenia, leukopenia.

Nā hopena dermatological: hiki i nā rashes ke kino.

ʻŌpū a me ka lactation

Penetrates ma o ka paepae placental. I ka wā hapai, contraindicated ma ka maʻi hypertension arterial. I nā hanana ʻē aʻe, hiki ke hoʻohana wale ʻia ma lalo o nā hōʻike koʻikoʻi i ka hopena liʻiliʻi loa a inā loaʻa ka hopena i manaʻo ʻia no ka hopena no ka makuahine e ʻoi aku ai ka hopena o ka wahine maʻi.

Hoʻopili ʻia ʻo Chlortalidone ma ka umauma umauma. Inā pono, e hoʻohana i ka wā o ka lactation, ʻo ka hōʻuluʻulu ʻana o ka waʻa e hoʻopau ʻia.

Nā ʻōlelo kikoʻī

Hoʻohana ʻia me ka makaʻala i nā mea maʻi me ka maʻi mellitus me ka gout, ka atherosclerosis koʻikoʻi o nā coronary a me nā moku cerebral, i hoʻopiʻi i ka hana exaletory o ka renal, i ka mea maʻi.

Ma ke kaʻina o ka mālama ʻana, pono ia e kāohi i ke kiʻi o ke koko, ka hoʻolālā electrolyte o ke koko, ka pae o ka uric acid, ka glucose i loko o ke koko.

Hoʻokomo i ka hiki ke lawe i nā kaʻa a kāohi i nā mīkini

ʻO Chlortalidone, ʻoi aku i ka hoʻomaka ʻana o ka mālama ʻana, hiki ke hoʻokaʻawale i ka hiki ke lawe i nā kaʻa a hana i nā mīkini.

Hoʻohui nūhou

Me ka hoʻohana pū ʻana me corticosteroids, amphotericin B, carbenoxolone, ke piʻi aʻe o ka hoʻoulu ʻana i ka hypokalemia koʻikoʻi.

Me ka hoʻohana like ʻana me NSAIDs, hiki ke loaʻa ka hopena o ka hopena o ka diuretic a me nā antihypertensive hopena o ka chlortalidone.

Me ka hoʻohana pū ʻana o ka hoʻomākaukau digitalis, hiki ke hoʻonui ʻia i ka ʻā o nā hopena ʻā o nā digitalis hoʻomākaukau ma muli o ka hypokalemia ma muli o ka hana o ka chlortalidone.

Me ka hana like o ka lithium carbonate, ʻo ke kahe o ka lithium i loko o ke kaila koko a me ka hiki i ka hoʻonui ʻana o ka lithium intoxication.

Ka hoʻonohonoho ʻana a me ke ʻano o ka hoʻokuʻu ʻana

i loko o kahi pahu pōpō o 10 pcs., i loko o kahi ʻeke pepa 5 mau ʻalani a i ʻole i loko o kahi pahu wai poʻomaʻo o 50 mau pcs.

Lapaʻau lāʻau

Mālama i ka hoʻihoʻi hou ʻana i nā kaila sodium (Na +), ka mea nui i ka tubule renal peripheral (cortical segment o ka pūle Henle), hoʻonui i nā excretion o nā iriona sodium (Na +), nā mālolo chlorine (Cl -) a me ka wai. Ka hoʻonui ʻana o ka paʻakai pākela (K +) a me nā magnesium ion (Mg 2+) ma o ka hanu, ʻoiai e hoʻoneʻe ana ka ʻāʻī o nā calcium calcium (Ca 2+).

E hana ana i ka emi iki o ke kahe o ke koko, ka nui o ka hopena o ka hypotensive e hoʻonui pinepine ʻia a hōʻike ʻia i nā wiki he 2 mau wiki ma hope o ka hoʻomaka ʻana o ka lāʻau.

I ka hoʻomaka ʻana o ka ho'ōla, e hoʻoheheʻe i ka nui o ka nui o ka wai o ka extracellular, BCC, a me ka nui o ke koko o ke koko, akā naʻe, ma hope o nā hebedoma e hoʻohana ai, e hoʻi ana kēia mau māka i kahi pae kokoke i ka mua.

E like me ka diuretics thiazide, hoʻoemi ia i ka hoʻemi ʻana i polyuria i nā mea maʻi me ka maʻi indipidus maʻi maʻi.

ʻO ka hoʻomaka ʻana o ka hana he 2-4 mau hola ma hope o ke kau ʻana, ʻo ka hopena loa ma hope o 12 mau hola, ʻo 2-3 ka lōʻihi o ka hana.

Nā Hoʻohui

hypersensitivity (a me ke aniani sulfonamide),

nā helehelena koʻikoʻi o nā nephrosis a me nephritis me ka hoʻokaʻawale ʻana o ka maʻi filtration glomerular,

molopala hana ino ole ana me anuria,

hepatitis koma, maʻi hepatitis

huki diabetes mellitus (formous form),

nā haunaele i ka paona wai-electrolyte,

nā keiki ma lalo o ke 18 mau makahiki o ka maikaʻi (a ʻaʻole i hoʻonohonoho ʻia ka maikaʻi a me ka palekana).

ʻo ka renal a me / a i ʻole kaʻohiʻana i ka nalo:

ʻōhumu lupus erythematosus,

Nā hopena hopena

Mai ka pūnaehana hana ʻana: nausea, luaʻi, gastrospasm, constipation a maʻi ʻole paha, intrahepatic cholestasis, jaundice, pancreatitis.

Mai ka ʻōnaehana hoʻonāukiuki: dizziness, paresthesia, asthenia (ʻano nāwaliwali ʻole a nawaliwali paha), disorientation, apathy.

Mai nā ʻike: ʻike maka (me ka xanthopsia).

Ma ka ʻāpana o ke koko a me ke ʻano o ke koko: thrombocytopenia, leukopenia, agranulocytosis, eosinophilia, aplastic anemia.

Mai ka pūnaehana cardiovascular: orthostatic hypotension (piʻi i lalo o ka mana o ka ethanol, anesthetics, sedative drug), arrhythmia (ma muli o hypokalemia).

Nā hōʻailona hana Laboratory: hypokalemia, hyponatremia (komo pū me nā hōʻailona neʻala - nausea), hypomagnesemia, hypochloremic alkalosis, hypercalcemia, hyperuricemia (gout), hyperglycemia, glucosuria, hyperlipidemia.

Nā maʻi kūwaha: urticaria, photosensitivity.

Nā ʻili: māhuahua ʻōwili, hoʻoneʻe i lalo.

Hoʻohui

Hoʻonui i ka loli o nā kaʻa lithium (Li +) i loko o ke koko (ma ka hihia inā Li + e hōʻake i ka polyuria, hiki iā ia ke loaʻa he hopena antidiuretic) a, no laila, e hoʻonui i ka nui o ka hoʻohālikelike me ka wai o Li +.

Hoʻonui i ka hopena o nā hoʻomaha hoʻomaha curariform a me nā lāʻau antihypertensive (me ka guanethidine, methyldopa, beta-blockers, vasodilators, BKK), inhibitors MAO.

ʻOiai e lawe ana i ka glycosides cardiac, hiki iā ia ke hoʻonāukiuki i ka arrhythmias cardiac i hopena mai ka intoekomo digitalis.

Hoʻohui ʻia ka hopena hypokalemic o ka lāʻau me ka hoʻopulapula i ka hoʻokele o GCS, amphotericin, carbenoxolone.

Hoʻokomo nā NSAID i ka hypotensive a me ka hopena diuretic o ka lāʻau.

E kūʻē i ka hope o ka hoʻohana ʻana o chlortalidone, kahi hoʻoponopono (hoʻonui a hoʻemi paha) i ka nui o ka nui o ka insulin a i ʻole ka hoʻonui ʻana i ka nui o ka lāʻau hypoglycemic lāʻau e koi ʻia.

ʻLoe a me ke kākele

I loko (maʻa mau ma ke kakahiaka, ma mua o ka ʻaina kakahiaka. Koho ʻia nā maʻi he hoʻokahi, ma muli o ka paʻakikī a me ke ʻano o ka maʻi a me ka hopena i loaʻa. Me ka hoʻomehana lōʻihi, ʻoi aku ia e kuhikuhi i ka palena haʻahaʻa loa e pono ai e mālama i ka hopena kūpono (ʻoi aku ka nui o nā maʻi maʻi).

Me ka haʻahaʻa o ka hypertension - 50 mg hoʻokahi manawa o ka lā 3 mau manawa i ka hebedoma.

Me ka maʻi edematous: ʻo ka maʻa mua he 100 mg o kēlā me kēia lā (ʻoi aku ka nui ma mua o 100 mg maʻamau ʻaʻole ia e hoʻonui i ka hopena diuretic), ʻo ka mālama mālama ʻia he 100-120 mg i kēlā me kēia lā 3 mau manawa i ka hebedoma.

Me nā ʻano renal o ka maʻi maʻi insipidus: o ka inau mua he 100 mg 2 mau manawa i ka lā, ʻo ka hoʻoponopono mālama ʻia he 50 mg i kēlā me kēia lā.

Ke keu

Nā Hoʻomaka huki, hoʻomaha, ka hiamoe, hypovolemia, nui ka hopena i ke koko, arrhythmia, convulsions.

Lāʻau: gastage gastage, ka manawa e koho ai i ka ulana, hoʻāla ka hōʻailona (e pili ana i ka iv infusion o nā hopena paʻakai e hoʻihoʻi ai i ka pale o ka electrolyte o ke koko).

Ka hana lāʻau lapaʻau

Hāʻawi ia i ka hana o ka reabsorption ikaika o nā ion sodium, ʻoi loa, i loko o nā tubula renal peripheral, hoʻonui i ka hoʻōla ʻana o ka chlorine, sodium a me nā wai wai. Hoʻomau ka maikaʻi o nā papa o nā kaluna ma o nā ʻōpū, a me nā huaʻai o ka magnesium a me ka pālei hoʻonui.

E kumu paha i kahi emi iki i ke kaomi. Hoʻonui ikaika ka ulu ʻana o ka hopena hypotensive, a hōʻike maoli ʻo ia iho i ʻelua a ʻehā paha pule ma hope o ka hoʻomaka ʻana o ka mālama ʻana.

Mālama ia i ka emi nui o ka nui o ke koko, BCC a me ka nui o ka wai extracellular, akā ke ʻike nei ka hopena i ka hoʻomaka ʻana o ka hopena. Ma hope o kekahi mau pule, lawe nā hōʻailona i kahi waiwai i kokoke i ka mea mua.

E like me ka diuretics thiazide, kōkua ia e hōʻemi i ka polyuria i nā mea maʻi me ka maʻi indipidus maʻi maʻi.

Hoʻomaka ka lāʻau lapaʻau e hana i nā manawa ʻelua a ʻehā mau hola ma hope o ka hoʻokō waha. Loaʻa ka hopena kiʻekiʻe ma hope o nā hola he ʻumikumamālua. Hoʻololi ka lōʻihi o ka hana mai nā lā a i ʻekolu.

Hoʻopuka - 50 pakeneka i nā hola 2.6. ʻO Bioavailability ʻo 64 ka pākēneka. ʻO ka pilina hāmeʻa Plasma he 76 pakeneka. Ma hope o ka lawe ʻana i ka lāʻau lapaʻau ma kahi o 100 a 50 mg paha, hiki i Cmax ma hope o 12 mau hola a ʻo 16.5 a me 9.4 mmol / L, ia manawa.

Hoʻololi ʻia ka hapalua hapa ola mai 40 a 50 mau hola. Hoʻokuʻu ʻia ia i nā loli a ke keiki. Hele ia i ka waiū umauma. E hōʻuluʻulu i loko o ka papaha ʻole o ka hana ʻole.

Nā hōʻailona no ka hoʻohana ʻana

Ua kuhikuhi ʻia ʻo Oxodolin no:

• ʻihio, nephrosis,
• haehae maʻi
• ake cirrhosis me ka portal hypertension,
• huni kūloko makahiki II,
• edema pilipine,
• waha hona i ka maʻi diabetes
• ʻopi momona.

Hōʻike, hoʻokuʻu i ke ʻano

Loaʻa i ke ʻano o nā papa keʻokeʻo. ʻAe ʻia kahi tinge kowhai. Hoʻokomo nā papa papa i loko o nā pahu aniani a i ʻole nā ​​blisters, a laila i nā pahu pahu.

ʻO ka mea kūpono i ka oxodoline he chlortalidone. Loaʻa nā mea kōkua i loko o ka huakaʻi: nā māla huaʻai, ke kōpaʻa waiū (lactose), ka waikawa calcium stearic (calcium stearate), haʻahaʻa haʻahaʻa polyvinylpyrrolidone.

Nā lono, nā manawa mālama

I kahi wahi anu, e pale ʻia mai ka mālamalama.

He mea paʻakikī kēia ke kiʻi iā Oxodolin i loko o nā lāʻau lapaʻau Lūkini, no laila ʻaʻole hiki ke kiʻi pono i nā loiloi e pili ana i ke kumukūʻai o ka lāʻau.

ʻAʻole maopopo i ka lāʻau lapaʻau Ukrainia ʻOksodolin.

ʻO nā ʻĀina iho ʻaeʻa e like me ka laʻala: Gigroton, Urandil, Edemdal, Hydronal, Isoren, Oradil, Renon, Urofinil, Apochlortalidon, Chlortalidone, Chlorphthalidolone, Famolin, Igroton, Natriuran, Phthalamidine, Saluretin, Zambezil.

Wahi a nā loiloi, hiki i kekahi ke hoʻoponopono i ka hana kiʻekiʻe o Oxodoline. ʻO nā maʻi me ka hypertension e ʻae maikaʻi i ka lāʻau lapaʻau.

ʻO nā loiloi o nā kauka nāna i kuhikuhi i ka lāʻau lapaʻau i kā lākou poʻe maʻi e hōʻoia i kēia mea.

Hōʻike pinepine ʻia nā mea kūpono ʻole, e ka maʻi kaumaha. Wahi a nā kauka, he kūpono ʻo Oxodolin no ka lāʻau lōʻihi.

E nānā i ka loiloi maoli ʻana i nā lāʻau lapaʻau maoli ma ka hopena o ka moʻolelo. E kaʻana like i kou manaʻo e pili ana iā Oxodoline inā ua lawe ʻoe iā ia a i kuhikuhi ʻole mai.

ʻO nā waiwai Pharmacological

Lapaʻau lāʻau
Hoʻopuka diuretic. Mālama i ka reabsorption ikaika o nā ion sodium (Na +), ka mea nui i ka tubule renal peripheral (cortical segment o ka pūle Henle), hoʻonui i nā excretion o Na +, chlorine ions (SG) a me ka wai. Ke hoʻonui nei nā kau o nā ʻai paʻakai (K +) a me nā magnesium ion (Mg 2+) ma o ka hanu, ʻoiai e hoʻoneʻe ana ka ʻāʻī o nā calcium calcium (Ca 2+). E hoʻolilo i kahi emi iki o ke kahe o ke koko (BP), ke piʻi nui nei ka ulu o ka hopena hypotensive a hōʻike piha i nā wiki he 2 ma hope o ka hoʻomaka ʻana o ka hopena.
I ka hoʻomaka ʻana o ka hana, hiki iā ia ke emi nui i ka nui o ka wai o ka extracellular, ka nui o ka neʻe i ke koko a me ka nui o ka minuke o ke koko, akā naʻe, ma hope o nā hebedoma e hoʻohana ai, e hoʻi ana kēia mau māka i kahi pae kokoke i ka mua.
E like me ka diuretics thiazide, hoʻoemi ia i ka hoʻemi ʻana i polyuria i nā mea maʻi me ka maʻi indipidus maʻi maʻi.
ʻO ka hoʻomaka ʻana o ka hana he 2-4 mau hola ma hope o ke kau ʻana, ʻo ka hopena loa ma hope o 12 mau hola, ʻo 2-3 ka lōʻihi o ka hana.

Lapaʻau lāʻau
Hoʻopilikia - 50% no nā hola 2.6. ʻO Bioavailability ʻo 64%. Ma hope o ka lawelawe waha ʻana he 50 mg a me 100 mg, ua hōʻea ka nui o ka nui ma hope o nā hola 12 a he 9.4 a me 16,5 mmol / L, ia manawa. Ke kamaʻilio pū ʻana me nā protein plasma - 76%.
ʻO ka pau ʻana he hapalua-ola he 40-50 mau hola.ʻāhā ʻia e nā keiki i loli ʻole. Penetrates i loko o ka waiū umauma. I ka hikiʻole o ka renal gagal, hiki iā ia ke hōʻiliʻili.

Pehea e hoʻohana ai: dosis a me ke ʻano o ka mālama ʻana

Me ka hoʻomehana lōʻihi, ʻoi aku ia e kuhikuhi i ka palena haʻahaʻa loa e pono ai e mālama i ka hopena maikaʻi loa, ʻo ia hoʻi i nā mea maʻi ʻelemakule.

Me ka haʻahaʻa o ka hypertension arterial - 25 mg hoʻokahi i ka lā a i ka 50 mg 3 mau manawa i ka hebedoma, inā pono, he nui pae aʻe a hiki i 50 mg / lā hiki.

I loko o ka edematous syndrome, ʻo ka hopena mua loa he 100-120 mg i kēlā me kēia lā, i nā pilikia koʻikoʻi, 100-120 mg / lā no nā lā mua (ma lalo o nā lā he 120 mg ʻaʻole pinepine e hoʻonui i ka hopena diuretic), a laila pono e hoʻololi i kahi papa mālama mālama o 100- 50-25 mg / lā 3 mau manawa i ka hebedoma.

Rina diabetes insipidus (i nā pākeke): mau mua ka hoʻomaka - 100 mg 2 mau manawa i ka lā, mālama mālama ʻia - 50 mg i kēlā me kēia lā.

ʻO ka awelika o kēlā me kēia lā no 2 mau keiki / kg.