Crestor: nā loiloi o nā maʻi e lawe ana i ka lāʻau lapaʻau

ʻO nā pōpō	10 mg	28 kiʻi.	≈ 1950.9 mau rubles
	10 mg	98 pcs.	≈ 5365.1 mau rubles
	20 mg	28 kiʻi.	≈ 4416.5 ʻōpala.
	40 mg	28 kiʻi.	≈ 5890 kahakaha.
	5 mg	28 kiʻi.	≈ 2123 rub.
	5 mg	98 pcs.	≈ 5595 rub.

Hōʻike nā kauka e pili ana i ke keʻa

Kalaha 1.3 / 5

Ioaaaia

Kūʻai / maikaʻi

Nā hopena hopena

ʻO kekahi o nā statine ikaika loa.

Hepatotoxicity. ʻO ia, me nā pōmaikaʻi hiki iā mākou, ua hōʻoia mākou i ka pōʻino.

Mai ka makahiki 70s, ua alualu ʻia kahi kulekele ʻōlelo i United States e hoʻokō i ke ola olakino i ʻAmelika. No laila, lawe mau nā penikala ʻAmelika i ALT a me AST i kēlā me kēia 3 mahina inā lawe lākou i nā statins. Eia naʻe, ʻaʻohe o mākou i kauoha ia.

Ka Helu 3.3 / 5

Ioaaaia

Kūʻai / maikaʻi

Nā hopena hopena

ʻO "Crestor" kekahi o nā statins mua, ke kumu e pono ai e noʻonoʻo ʻia i ka wā e hui pū ai i ka dysectope erectile me ka dyslipidemia. ʻAʻole i maikaʻi ʻole i ka hoʻomaʻamaʻa ʻana i ka ʻōlelo lipid. Me ka hui pūkaukau hoʻokūkū, ʻike maikaʻi ʻia nā hopena maikaʻi loa e like me ka pae o ka erectile dysfunction ma hope o 2-3 mau mahina o ka hoʻokomo maʻamau. Koho ʻia ka ʻ individuallykole i kēlā me kēia, e like me ka ʻōlelo a ka lipid. Hoʻolaulaha i ka antiioxidants.

He nui ka lāʻau, akā naʻe, pono ia ʻo Krestor. ʻO ka hiki ke loaʻa ka hana o ka ʻōpū.

Ka Helu 4.2 / 5

Ioaaaia

Kūʻai / maikaʻi

Nā hopena hopena

Kōkua nō ia, hoʻemi ka pae o LDL, he maikaʻi ia me ka ʻano papa papa ʻōlelo ʻana, no laila ʻaʻole ʻoe e hoʻōki i ka lawe ʻana i ka lāʻau ma hope o ka hopena hopena o ka hopena therapeutic.

Hoʻolaha ʻia kahi hopena maikaʻi o ka lāʻau lapaʻau i ka maʻalahi a maʻalahi i ka mālama ʻana i ka cholesterol koko.

Ka Helu 4.6 / 5

Ioaaaia

Kūʻai / maikaʻi

Nā hopena hopena

Nā statin punahele. ʻAe, aloha, akā no ke kumu maikaʻi. ʻO ka lāʻau kanu kumu, i.e. noiʻi maikaʻi. Maikaʻi ke ʻano maikaʻi, hiki ke hoʻēmi ʻia ka lipid ka manawa e pono ai. Mai haʻalele i ka kaohi o nā enzyme i ka wā e lawe ai i ka "Crestor" a i ʻole kekahi statin ʻē aʻe. ʻEā, a, ʻoiaʻiʻo, e poina e komo ka statin intake, me nā mea ʻike ʻokoʻa, kū ʻole, ʻaʻole papa.

Kalaha 2.9 / 5

Ioaaaia

Kūʻai / maikaʻi

Nā hopena hopena

ʻO ka lāʻau mua, rosuvastastine. He hoʻohaʻahaʻa maikaʻi ia i ka cholesterol. Loaʻa i ka hana pono no ka pale mua ʻana o nā hoʻopiʻi cardiovascular.

ʻO ka lāʻau lapaʻau nui loa, ʻaʻole hiki i nā mea āpau ke uku.

I ka wā e komo ai, e pono ai ke kaohi o ka ʻōlelo lipid a me ALT, pono ʻia ka AST. Lawe ia i ka manawa 1 i ka lā, i ke ahiahi.

Ka Helu 3.8 / 5

Ioaaaia

Kūʻai / maikaʻi

Nā hopena hopena

ʻO Krestor kahi lāʻau lapaʻau maikaʻi loa o nā statins a pau. Me ka hoʻokumu kumu. Ma hope o 1.5-2 mau mahina o ka hoʻohana mau ʻana, ʻike ʻia nā hopena. Ua kuhikuhi ʻia i ka manawa 1 i kēlā me kēia lā, koho ʻia ke kaha kū hoʻokahi, ʻoiai e lawe ana i ka lāʻau lapaʻau, ka kaohi o ka mahele lipid koko, ALT, AST.

Ua kiʻekiʻe ke kumukūʻai, ʻaʻole loaʻa nā maʻi āpau.

Hoʻomaʻamaʻa ʻia ka lāʻau lapaʻau, ʻoluʻolu wau i kaʻu mau mea maʻi.

Ka Helu 3.3 / 5

Ioaaaia

Kūʻai / maikaʻi

Nā hopena hopena

No 2 mahina, ʻaʻole i koho ʻia ka luna bapetizo, no laila, "i mea e pale ai i ka hoʻomohala ʻana mai o nā palaki." Ua hōʻike ʻo Krestor i ka hiki ke hōʻemi i ka nui pākeke ma hope o 2 mau makahiki o ka hoʻokele ʻana i kahi maʻa o 40 mg i kēlā me kēia lā. Ma keʻano holoʻokoʻa, inā ʻae nā ʻoihana kālā, ʻaʻohe mea maikaʻi ma mua o ka lāʻau lapaʻau mua. A ʻo ka rosuvastatin kumu mua ʻo Krestor. Akā inā eia ka nīnau: ʻaʻole e mālama ʻia, a i ʻole e lawe i kahi kūlana kiʻekiʻe, no laila, ʻoiaʻiʻo, ʻoi aku ka maikaʻi o kahi mea ola loea maikaʻi. He mea pono ka hoʻomanaʻo o nā hopena lōʻihi loa o ka rosuvastatin - kahi i hoʻokaʻawale i ka make, ka hoʻokaʻeha o myocardial infarction a me ka peʻa - i hōʻike wale ʻia no Crestor, no ka mea ʻaʻole i aʻo ʻia ke koena o nā generics ma kēia ala. ʻOiai, ʻoiaʻiʻo hoʻi, he mea hoʻonoho kūpono e hoʻomau i ka hoʻohālikelike i ka cholesterol i ke koko, a pono e hoʻāʻo ʻia ia no ka ʻike o nā haʻawina kūpono.

ʻO ke drawback wale nō ke kumukūʻai. ʻOi loa i kēia manawa, ma hope o ka hoʻololi o ke kumu kūʻai. He hiki ke kūʻai - e kūʻai iā ia. E makaʻala ʻoe i ka mālama ʻia me kekahi statin ʻaʻole i hana ʻia e hoʻohaʻahaʻa i ka cholesterol, akā e hōʻemi i ka hiki i ka myocardial infarction, ischemic stroke a me ka make mai nā kumu cardiovascular. ʻO kēlā e lawe ʻia nā statins i mau makahiki. A laila e palekana pono ʻia ʻoe mai nā pilikia i hōʻike ʻia. Inā aloha ʻia ke keʻa iā ʻoe, a laila ʻoi aku ka maikaʻi ma ka hoʻomaka ʻana i kahi ʻanoʻano nani koke. No ka mea, ʻaʻole e ʻike ʻia nā pōmaikaʻi mai ka lawe ʻia ʻana ma hoʻokahi mau mahina ʻelua a ʻekolu mau malama. ʻO ka emi ʻana o Cholesterol, akā, ma ka nui a me ka nui o nā statins i lawe ʻia ʻole e hoʻohaʻahaʻa i ka kolamu, akā e hōʻemi i ka hopena o ka pilikia ma ke ʻano o ka myocardial infarction, stroke, etc. A ʻo kēia pilikia, me he rula, e hoʻomaka i ka emi wale ʻana ma hope o nā mahina he nui mai ka hoʻomaka ʻana o ka lawe ʻana i nā statins.

Inā hele mai nā hopena hopena i loko o ka mea maʻi hoʻokahi, ʻaʻole loa kēia manaʻo e hana like ka mea like i nā mea āpau. No laila, no ka hoʻolohe ʻana i kekahi mea i loaʻa i ke keʻa (a i ʻole mea ʻē aʻe) a loaʻa i nā ʻano mea ʻole maikaʻi ʻole, ʻaʻole hoʻi lawe e lawe i kēia i kāu moʻolelo ponoʻī. ʻAʻohe hiki ke hiki ke wānana i ka hopena o nā hopena ʻaoʻao i kahi maʻi maʻi kūikawā. Pono ʻoe e hoʻomaopopo he mea kūpono ke mālama ʻia me ke kea i ka wā hiki i kou hiki ke kūʻai aku no ia i nā makahiki. A i ʻole, e kūʻai koke i ka generic kiʻekiʻe-nui a mālama ʻia me ia (no ka laʻana, mertenyl, a i ʻole roxer, a i ʻole tevastor).

Ka Helu 4.2 / 5

Ioaaaia

Kūʻai / maikaʻi

Nā hopena hopena

ʻO ka lāʻau maikaʻi loa o nā statins a pau. Hoʻololi wikiwiki i ka kolamu a i ka pae kiʻekiʻe. ʻAʻole i like me nā analogue, ka hopena therapeutic a emi i nā haʻahaʻa haʻahaʻa.

ʻO ke kumukūʻai, ʻoiaʻiʻo, he nui! ʻAʻohe paio. ʻAʻole hiki i nā kānaka āpau ke loaʻa.

ʻO ka lāʻau mua. Kupanaha ka waihona hōʻike. Akā haʻalulu ka kumukūʻai i ka hapa nui o nā maʻi e pono ai.

Ka Helu 3.3 / 5

Ioaaaia

Kūʻai / maikaʻi

Nā hopena hopena

Mālama koke ia i nā pae kolamu (ma ka hebedoma hiki iā ia ke hoʻohaʻahaʻa i nā hōʻailona ma ka maʻamau).

Hoʻopau maikaʻi ʻia ka lāʻau lapaʻau, me kahi waihona hōʻike nui, ʻoi aku ka maikaʻi. Kahi ka hana i nā helu liʻiliʻi i hoʻohālikelike ʻia i nā lāʻau lapaʻau ʻē aʻe o kēia hui. Ua hoʻomaopopo ʻia. I ka nui o nā hihia, e hoʻomau ʻia ka hana mau.

ʻO nā loiloi hoʻomanawanui e pili ana i ke keʻa

Lawe wau iā Krestor no 2 mau wiki, hoʻomaka koʻu mau wāwae wāwae e hōʻeha, ʻaʻole hiki iaʻu ke hiamoe, lawe wau i nā mea hōʻeha, he hebedoma i hala iho nei. Ma hope o ka hoʻopau ʻia ʻana o ka eha, loaʻa mau ka ʻeha manamana o ka ʻāʻī, a ua hōʻeha ka ʻeha ʻo ka ʻāʻī, ke kali aku nei au i kekahi hebedoma a hiki i ka lāʻau ke haʻalele ʻana i ke kino, a inā ʻaʻole e hele ka ʻeha ʻana i ka neurologist. ʻO ka lawe ʻana, pono ʻoe e hoʻolohe i nā mea i kākau ʻia i nā ʻōlelo aʻoaʻo, ʻaʻole ʻike ʻia i ke ʻano o ke akeʻa. E akahele, me he mea ʻole ke noiʻi ʻia ʻana o ka lāʻau lapaʻau.

Ua make kahi hoa ma Kanada e pili ana i ka maʻi maʻi pancreatic. ʻO ka mea mua i hana ai i ka forcologist ma hope o ke kū ʻana i ka maʻi me ka kākau ʻana i nā lāʻau āpau āna e lawe nei. I waena o lākou he ke kea. Ua pāpā koke akula ʻo ia iā ia. Ke hoʻohuli nei lākou ma Kanada e hoʻāʻo nei lākou e koho iā ia. Aia nā manaʻo koʻikoʻi i hiki i kēia lāʻau ke hōʻeha.

Ua inu ʻekolu ʻo Papa ma Krestor no ʻekolu mau makahiki. ʻO ka lāʻau lapaʻau wikiwiki a hoʻohaʻahaʻa i ka cholesterol. Makemake lākou e kāpae i ka lawe ʻana i ka lāʻau, akā ma hope o ka hāʻule ʻole, ala hou ke kolamu. No laila, hoʻonui wau i ka lawe ʻana i nā pilala. Ma hope o kēlā, hoʻomaka ka pāpā e hoʻopiʻi ai i nā hōʻeha, ke olakino maikaʻi, ʻo ka hiamoe maikaʻi ʻole. ʻIke mākou i nā kumu no ka manawa lōʻihi, i hala i nā ʻano hōʻike like ʻole. I ka hopena, ua hoʻohuli ʻia ka pilikia o kona makuakāne. Ua lilo ka hoʻohana ʻana i ka lāʻau lapaʻau.

ʻOluʻolu loa me ka lāʻau lapaʻau, hōʻemi wikiwiki a kokoke me nā hopena ʻole. Ma ka wā hoʻomaha wale nō wau e inu ai ʻo Essential Forte N.

Ua hoʻokuʻu ke kauka i nā malama 2 no ka pale ʻana i ka hoʻomohala ʻana i ka lāʻau. Kūleʻa (e like me ka mea kumu). ʻAʻohe oʻu mea pili ʻole i kēlā me koʻu ola! Kekahi ʻano o ka pustular rash ma luna o ke kino. Ua inu au i ka lā 4, no ka mea ua manaʻo wau ua hiki iā Magnerot ke hui pū pū. ʻIke wau i kēlā ma Krestor ma hope o nā mea āpau. Pehea e ola ai? Wehe ʻole i nā hopena.

ʻO kahi infocococion ma Myocardial e noʻonoʻo iaʻu a noʻonoʻo i ka mea aʻu i hana ai me koʻu olakino! Hele aku nei i ka simulator. Ua hoʻokiʻekiʻe nui koʻu kolamu, no laila ua ʻōlelo lākou i kahi meaʻai paʻa, ma ka kuke ʻana a hoʻomoʻi wale nō, ʻoliʻoli wau i hiki iaʻu ke ʻai i nā hua, ʻāpopo paʻa i ka ulaula, paʻakikī kēia mea a pau. Ua hoʻāʻo wau iā Krestor - ʻaʻa wau iā ia e like me ka mea i kauoha ʻia, akā ʻaʻole wau i nānā i ke ʻano maʻi kūlohelohe. Ua lilo i mea maʻalahi i ka hanu, ʻoi aku wau i ke kāʻei, e hoʻomaʻamaʻa pū me ka mea kaua. ʻO ke kōkua o nā paila, akā he maikaʻi nō hoʻi ka hoʻomaʻamaʻa. ʻAʻole maopopo iaʻu, akā ʻoi aku kaʻu hana maikaʻi me nā pālima, i kēlā manawa kēia manawa, i ʻole e hoʻomaʻamaʻa maʻamau, ke hoʻohewa nei au i ka mālama ʻana.

Ua kuhikuhi ʻia kahi keʻa kāne i kaʻu kāne ma hope o kahi hōʻā ʻana. Ua hōʻike nā mau loiloi he nui kāna kolamu i loko o ke koko a no laila pono e hoʻemi wikiwiki i kēia mau kuhikuhi. Me ka hoʻohana maʻamau o kēia lāʻau lapaʻau a me ka lāʻau koʻikoʻi koʻikoʻi, hoʻomaka ka pae kolamu i ka emi. Ma hope o hoʻokahi mahina e hōʻike ai nā hana noiʻi i hiki i ke kiʻekiʻe o ka kolamu koko a hiki i kahi pae i hiki ai. Kaukau ʻia e ke kauka ke lawe ma hope o kēlā, akā he lāʻau lapaʻau ʻoi loa ia a ʻaʻole hiki i nā mea āpau ke lawe aku iā lākou no kekahi manawa lōʻihi.

ʻO ka wehewehe pōkole

ʻO Krestor (ʻo ka mea ola he rosuvastatin) kahi hana lipid-hoʻemi haʻalulu maoli i lilo i ka pūʻulu o nā poʻe selective inhibitors o ka enzym HMG-CoA reductase, i ʻike ʻia me nā statins. ʻO ka hanohano o ka "huna" o ka hypertension arterial i lōʻihi i ko mākou ʻāina. Ma muli o ke koko kiʻekiʻe e lilo i kumu nui o ka maʻi a me ka make ma ka maʻi cardiovascular. ʻAʻole ia he mea huna o ka ulu ʻana o ka hypertension arterial i hele lima me nā maʻi metaboleka ʻē aʻe, e like me ka intolerance glucose, hyperinsulinemia (nui ka honi ʻana i ka insulin), hypeuricemia (nui ka waikau uric i ke koko), huʻihui a me nā dyslipidemia (nā hana lipid metabolidame). Ma ka hopena hope loa, pili ka hypertension me ka hoʻonui i ka ʻike o nā peka lipher atherogen a, ma muli o kēia, ka hoʻomohala ʻana i ka atherosclerosis. Wahi a nā hopena noiʻi, hele mai ka hypercholesterolemia ma mua o 40% o nā maʻi lapaʻau o ke koko kiʻekiʻe. ʻO ka mahalo, i nā maʻi maʻi hypertensive kāne, ʻoi aku ka maikaʻi o ka lipid lipher i hoʻohālikelike ʻia i ka wahine. ʻO ka ʻike kūpono ʻole i uku ʻia i ka hoʻoponopono ʻana i ke koko, me ka hoʻopau ʻana i nā mea pili i ka puʻuwai, a me ka dyslipidemia, e alakaʻi i ka hoʻomohala a me ka holomua o ka atherosclerosis. Ma kēia e noʻonoʻo ai, ka maʻamau o ka hana lipid metabolism kekahi o nā pahuhopu nui o ka hoʻokele ʻana i nā poʻe maʻi me ka haʻi hypertension, he ʻano o ka hoʻokō ʻana, me ke ʻano o ke hoʻoponopono ʻana i ke ola, ka hoʻohana ʻana o statins. Hōʻike pololei nā hualoaʻa i nā hōʻike kulekele nui e ʻike nui ʻia ana ka statins i ka hōʻemi ʻana i nā hanana o nā hanana cardiovascular. Aia kahi kahua kūikawā i waena o nā mākaʻi o kēia hui lāʻau lapaʻau e noho ʻia e rosuvastatin (cross), ma muli o ka loaʻa o nā pōmaikaʻi lehulehu ma luna o nā "hoaʻi i ka hale kūʻai". ʻO Krestor kahi lāʻau lapaʻau i hoʻohana ʻia ma ka cardiology mai 2003. Ua loiloi ʻia kāna ʻoihana pono ma ke ʻano o nā hoʻokolohua, i hui ʻia ma lalo o ka inoa inoa GALAXY a e uhi ana ma mua o 45 tausani mau mea komo.

I loko o ka hoʻolālā o kēia papahana, ka hopena maikaʻi o ka lāʻau lapaʻau ma ka ʻaoʻao lipid, nā māka o ka hoʻōla ikaika, ke ʻano o ke ʻano o ka hana atherosclerotic. Ke hoʻohana nei i ke kea i ka nui o nā pona i ʻōlelo ʻia, e hoʻokaʻawale ana ke pae o ka "maikaʻi" kolesterol (LDL) e 52-66% i ʻike ʻia, ma mua o nā waiwai like ʻole no nā statins ʻē aʻe. Eia kekahi, i ka wā e mālama ai me ke kea, ʻoi aku ka nui o ka cholesterol "maikaʻi" (HDL) e hoʻonui - e ka awelika o ka 14%, me ka hoʻohaʻahaʻa wale ʻana ma nā triglycerides. Hāʻawi i ka hana koʻikoʻi o ka hopena o ke ʻano maʻi i loko o ka pathogenesis o atherosclerosis i kēia manawa, ke kānalua nei, hāʻawi ʻia ka ʻike kūikawā no nā kumu ʻike anti-inflammatory o ke keʻa. Ua hōʻike ʻia kahi hōʻike i hōʻike ʻia i ka lāʻau e hōʻike pono ana i kona pono i ka atherosclerosis coronary: ʻelua mau makahiki o ka mālama ʻana i ka mālama ʻana i nā pōmaikaʻi ʻaʻole wale i ka hoʻomaikaʻi ʻana i ka maikaʻi lipid a me ka hoʻohālikelike i nā mākaʻeha o ka maʻi, akā i ka neʻe ʻana i ka atherosclerosis i ka coronary a me ka carotid arteri. Pēlā, ke noʻonoʻo pono nei ke keʻa i ka lāʻau maikaʻi loa e hoʻopili ʻia e pili ana i ka hoʻoponopono ʻana o ka maikaʻi lipid, akā i ka pale ʻana i ka hoʻomohala ʻana o ka atherosclerosis. Hoʻohana maikaʻi ka hoʻohana ʻana o ke keʻa ma ka pale ʻana a me ka lua kūwaho o ka maʻi naʻau coronary. Hoʻopuka ka hopena lapaʻau o ka lāʻau i loko o 7 mau lā, a ma hope o hoʻokahi mahina o ka pule o nā lāʻau lapaʻau i kona kiʻekiʻe.

Hōʻulu ʻia ke keʻa ma nā papa, pono e ale ʻia ʻ wholelelo piha, ʻaʻole wawahi, holoi ʻia me ka wai i lawa. Hiki ke kiʻi ʻia ka lāʻau i kēlā me kēia manawa o ka lā. Ma mua a i ka wā o ka mālama ʻana, pono ka mea maʻi e hahai i ka ʻai maʻamau hypocholesterolemic. Kahi ʻia ka nui o ke keʻa ma kēlā me kēia ma muli o nā pahuhopu o ka mālama ʻana, ka hopena nānā a me ke ahonui.

Crestor: nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana

Ka hana lāʻau lapaʻau	Hoʻopau ʻo Krestor i ka koloka "LDL" kino i loko o ke koko, ma ke kāpae ʻana i kāna hana ʻana i ka ate. Hoʻopili ʻia ia i ka ʻike o ka triglycerides, apolipoprotein B, nā lipoproteins haʻahaʻa haʻahaʻa (VLDL). Hoʻokumu i ka cholesterol "HDL" maikaʻi. Hoʻēmi i ka maʻi ʻaʻai luhi ma loko o nā moku. Hoʻonui i ka protein C-reactive a me nā mea hōʻailona e pili ana i ka mumū. Hoʻomaka nā hopena o nā hōʻike koko ma hope o nā hebedoma 1-2, ka hopena kiʻekiʻe - ma hope o nā hebedoma 2-4.
Lapaʻau lāʻau	Hiki ke lawe ʻia nā papa Rosuvastatin me ka meaʻai a ma luna o ka ʻōpū ʻole, ʻaʻole e loli ka hopena o kēia hana. Hoʻopili ʻia ʻo Rosuvastatin mai ke kino ma ka 90% e ka puʻu ma o ka ʻōpū, ma o 10% - nā keiki. Ua emi iki ia me nā statins ʻē aʻe, e hoʻouka ai i nā ʻōnaehana lawelawe pili i ka hoʻomaʻemaʻe ʻana i ke koko o nā mea ikaika a me nā lāʻau lapaʻau. Ma muli o kēia, ua ʻoi aku kāna mau lono ma mua o nā hōʻuluʻulu ʻana ma mua o nā statins mua.
Nā hōʻailona no ka hoʻohana ʻana	Hoʻokomo ʻia ka kolikole kiʻekiʻe ma ka pākeke a me nā ʻōpio. Ke hōʻike nei i ka hoʻolālāʻana o ka atherosclerosis. ʻO ka pale ʻana i ka hōʻeha ʻana a me ka hana hou ʻana i ka puʻuwai, ischemic stroke a me nā pilikia ʻē aʻe o ka atherosclerosis. Ma hope o ke kaʻina hana e hoʻihoʻi i ke kahe koko i loko o nā moku i loaʻa i ka atherosclerosis. Hoʻohui i ka protein C-reactive i ke koko ma ke alo o nā mea koʻikoʻi cardiovascular riska, ʻoiai inā he maʻi maʻamau ka cholesterol. ʻO ka lawe ʻana i nā papa Krestor ʻaʻole kahi ka mea pono i ke ola kino. E aʻo i ka ʻatikala "Prevention of heart heart and stroke" a hana i kāna mea e ʻōlelo ai. Inā ʻaʻole, e kōkua liʻiliʻi ka lāʻau lapaʻau.

E nānā i ke wikiō:

ʻĀnō	Hoʻomaka me kahi maʻi o 5 a 10 mg paha i ka lā. Ma hope o 4 mau pule, hiki ke hoʻonui ʻia ke ʻano o Krestor, hāʻawi ʻia i ke ʻano o ka pae o ka cholesterol i loko o kēia manawa a pehea ke ahonui nei ka mea maʻi i ka mālama ʻana. E aʻo i ke kolamu koko no nā kāne a me nā wahine ma o nā makahiki. ʻO ka maʻamau, lawe ka poʻe maʻi i ka rosuvastatin 10-20 mg i kēlā me kēia lā. ʻO ka nui loa ka nui o ka 40 mg e kuhikuhi ʻia i nā poʻe he nui ke kolamu ma muli o nā maʻi maʻi genetic. ʻO nā kānaka'ōpiopio, a me nā mea maʻi e loaʻa ʻōlohelohe a i ʻole hepatic insufficiency, ua ʻōlelo ʻia iā rosuvastatin i nā palahalaha maʻamau.
Nā hopena hopena	ʻO nā papa Krestor, e like me nā statins ʻē aʻe, hiki ke hōʻeha i ka ʻehaʻeha o ka naʻau, nāwaliwali, nā luhi, ka hoʻomanaʻo ʻana a me ka noʻonoʻo ʻana i nā luhi, nui ʻole, a me nā haʻalulu hoʻoluʻu.E nānā i ka ʻatikala "ʻaoʻao hopena o statins" - e ʻike pehea e hōʻoluʻolu i nā hōʻailona leʻaleʻa a hoʻopau loa iā lākou. Loaʻa i ka hoʻomākaukau ʻana o Rosuvastatin i nā hopena pilikino kūikawā. E heluhelu hou aku i ka palekana o ka rosuvastatin. No nā poʻe e ʻeha nui ka hōʻeha o ka puʻuwai a me nā hōʻeha, ʻoi aku ka maikaʻi o nā statins ma mua o ka hōʻeha. Pono e hōʻemi ʻia kēia lāʻau lapaʻau inā hiki ʻole nā hopena hopena a hiki ʻole ke hoʻokaʻawale iā lākou. Hoʻopili ʻia ka pilikia o ka pilikia o ka ate. Mai hopohopo iā lākou inā ʻaʻole ʻoe e hōʻino i ka waiʻona.
Nā Hoʻohui	ʻO ka maʻi ʻeha i ka hana ikaika. ʻO ka hoʻonui nui loa e pili ana i nā ateme ALT a me AST i loko o ke koko. Hōʻea aulei maikaʻiʻole - clearance clearance ma mua o 30 ml / min. ʻO ka hypersensitivity i rosuvastatin a i ʻole nā mea hana i kūkulu ʻia i nā papa. I nā ʻāina e ʻōlelo ai ka Lūkia, ʻo ka makahiki ma lalo o 18 ka mea i manaʻo ʻia he contraindication, ʻoiai ma nā ʻāina ʻē aʻe, ua ʻōlelo ʻia ka hoʻomākaukau ʻana no ka rosuvastatin no ka wā'ōpiopio e hoʻomaka i ka makahiki 10.
Hāpai a me nā pēpē	Krestor, nā lāʻau lapaʻau ʻē aʻe o ka rosuvastatin a me nā statins ʻē aʻe i paʻa i ke kime o ka wā hāpai. Pono nā wahine o nā keiki hānau keiki i mālama ʻia me nā statins e hoʻohana i nā contraceptives pono. Inā he hana hoʻolālā ʻole ʻia, a laila e hoʻopau koke i ka peni no ka cholesterol. E pale aku i ke ʻano o ka mālama ʻana me kēia lāʻau lapaʻau, ʻaʻole hiki iā ʻoe ke ʻae umauma.
Hoʻohui nūhou	Hāʻawi nā papa krestor i nā liʻiliʻi me nā hopena ʻē aʻe ma mua o nā statins mua. Akā, e noho mau ka pōʻino. Aia nā pilikia me nā antibiotika, nā mea hoʻohālikelike, nā puʻukui hoʻomalu, hānau ʻia ke koko, a me nā mea ola he nui loa. Hiki i kēia mea ke hōʻeha i nā hopena koʻikoʻi - hana i ke kua a me ka hana o ka aʻalolo. E kamaʻilio me kāu kauka! Ma mua o kou kau ʻia ʻana i nā ʻenekini, haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau, nā mea kanu meaʻai, a me nā mea kanu āu e lawe nei.
Ke keu	ʻAʻohe mālama kūikawā no ka overdose me Krestor. Hāʻawi nā kauka i ka hana hōʻailona a me ke ana kōkua, ka mālama ʻana i ka hana o ka ate a me ka kiʻekiʻe o ka hana o ka phosphokinase creatinine. ʻAʻole kōkua Hemodialysis e wehe i ka rosuvastatin mai ke kino.
Nā ʻōlelo kikoʻī	Hoʻomaka e mālama ʻia me nā statins, e hoʻomau i ka hahai ʻana i kahi papaʻai a alakaʻi i ke ʻano olakino olakino. Manaʻo ʻia e nānā i nā hana maʻamau i ka hoʻohana ʻana i ka hoʻāʻo a me ka hoʻāʻo ʻana i ka wai a me ka urine. Inā ʻike ka protein i loko o ka urine a ulu paha kona manaʻo, e mālama pono i ke kauka. Inā nele ʻoe i nā hormone thyroid, a laila mai holo ʻoe e lawe i statins, akā e mālama i ka hypothyroidism e hoʻihoʻi i ka cholesterol i nā maʻamau. Krestor a me nā lāʻauʻokoʻa ʻē aʻe o ka rosuvastatin hoʻonui i ke kōhi koko i nā mea maʻi me ka maʻi maʻi a me ka prediabetes.
E hoʻokuʻu i ke ʻano	ʻO nā papa papa kiʻi 10 ka 20, 20 a me 40 mg. I nā pila mai loko mai o ka laminate alumini a foil paha, 7 a i ʻole 14 papa. I loko o kahi pahu o nā kāleka, 1, 2 a i ʻole 4 mau palaka.
Nā kuleana a me nā kūlana e waiho ai	E mālama i ka maloʻo, pale ʻia mai ka mālamalama, ka wahi i loaʻa ʻole i nā keiki, ma ke kau wela ʻaʻole ma luna o 30 ° C. ʻO 3 mau makahiki kahi ola i nā pale.
Hōʻike	ʻO ka mea ola e hoʻohana ai i ka calcium kalu rosuvastatin. Nā mea hoihoi - lactose monohydrate, MCC, calcium phosphate, crospovidone, magnesium stearate. ʻO ka pūpū o ka papa pāpē he lactose monohydrate, hypromellose, triacetin (glycerol triacetate), titanium dioxide, ulaula pōpilikia ʻona ulaula.

Makemake ka nui o nā mea maʻi e kahuli i ka lāʻau lapaʻau ʻo Krestor me kekahi mau analogue, ʻoi aku ka loaʻa, ʻo ka like me ka mea like. ʻO ke wikiō ma lalo nei e kōkua iā ʻoe. Nānā iā ia e hana i ke koho kūpono ma waena o nā papa rosuvastatin he nui i loaʻa i ka lāʻau lapaʻau.

Nā Crestor: nā manaʻo

Ma nā pūnaewele ʻōlelo Lūkini hiki iā ʻoe ke loaʻa i nā loiloi o nā loiloi e pili ana i ka lākē Krestor. He mea kaulana kēia mau paila, ʻoiai ma ko lākou kumukūʻai nui. I ka manawa e kākau ai nā kānaka i nā loiloi e pili ana i nā lāʻau lapaʻau aʻe o ka rosuvastatin (Mertenil, Roxer, Rosucard), ʻōhumu pinepine lākou no nā ʻaoʻao pili. ʻO nā loiloi e pili ana i ka lāʻau lapaʻau Krestor piha i nā hoʻopiʻi kūpono e pili ana i kona kumukūʻai kiʻekiʻe. Akā liʻiliʻi kekahi mea kākau i nā hopena ʻaoʻao. Hoʻomaʻamaʻa nui nā mea hoʻopuka ma ka pūnaewele olakino no ka mea i hoʻolaʻa ʻia ka lāʻau rosuvastatin kumu i kā lākou kolamu. Huhu wale lākou i ka nui o ke kālā i uku ʻia no ia.

Ua maopopo ka poʻe maʻi i ka mea a lākou e lawe nei i ka rosuvastatin, ʻaʻole e loaʻa nā hopena a i ʻole ʻia lākou. Ma kahi o ke koho ʻana i ka lāʻau lapaʻau Krestor, ke koho ʻana i kāna mau analogues e ʻoi aku ana - Mertenil, Roxer, Rosucard a i ʻole nā mea ʻē aʻe - mālama ka poʻe i ke kālā. Eia nō naʻe, hilinaʻi lākou ma muli o ka mālama kālā e loaʻa iā lākou nā hopena ʻē aʻe. ʻOiai ua hōʻike ʻia nā noi e pili ana i ka pleteboe i kēia ʻaʻole pela. ʻO ka hapa nui o nā hopena ʻokoʻa o nā statins e kanikau nei nā kānaka i kā lākou loiloi ma muli o ka noʻonoʻo subconscious o nā mea maʻi, ma mua o ka hopena maoli maoli o nā lāʻau.

Nā hōʻailona no ka hoʻohana ʻana

ʻO ka hypercholesterolemia maʻamau o Fredrickson (type IIa, me ka familial heterozygous hypercholesterolemia) a i ʻole ka palaualulu ʻana i ka hypercholesterolemia (type IIb) ma ke ʻano o ka ʻai, i ka wā e ʻai ai nā meaʻai a me nā lāʻau lapaʻau ʻole (like ka hana e hōʻemi ana i ka momona,) ʻaʻole pono.

ʻo ka hypercholesterolemia ʻO ka ʻohana homonezygous ma ke ʻano he meaʻaiʻai a me nā ʻano lāʻau haʻahaʻa lipid-hoʻohaʻahaʻa (no ka hoʻohālike, ʻo LDL-apheresis) a i nā hanana kahi kūleʻa like ʻole ka hopena,

hypertriglyceridemia (type IV ma muli o Fredrickson) i mea hoʻonui i ka meaʻai,

ke hoʻolohi nei i ka holomua o ka atherosclerosis, i kahi hoʻohui i ka mea ʻai i nā mea maʻi e hōʻike ʻia ana ka lāʻau e hōʻemi i ke kaila o ka kolamu a me LDL-C,

ka pale mua ʻana o nā hoʻopiʻi cardiovascular nui (hōʻeha, ka hōʻeha ʻana o ka naʻau, ka ʻokiʻoki o ka arterial) i nā maʻi pākeke me nā hōʻailona ʻole o ka maʻi coronary heart disease, akā me ka piʻi nui o kona ulu ʻana (ma luna o 50 mau makahiki no nā kāne a ʻoi aku ma luna o 60 mau makahiki he mau kāne, ua hoʻonui ʻia ʻo C-reactive ka protein (≥2 mg / l) ma mua o ka liʻiliʻi i kekahi o nā mea e pili ana i ke kinikini, e like me ka arterial hypertension, haʻahaʻa haʻahaʻa o HDL-C, ulaula, kaʻikepili ʻohana i ka wā hoʻomaka o ka maʻi naʻau coronary).

Kūkākūkā o ka lāʻau lapaʻau Crestor i nā moʻolelo o nā makuahine

No ka hoʻohālikelike, hoʻohālikelike nā kaikamahine i ʻelua mau lāʻau lapaʻau e hoʻohaʻahaʻa i ke kolamu koko Krestor 10 mg papa no 28 - 1337 rubles, ka mea ola ʻo rosuvastatin, mea hana - AstraZeneca-IPR Pharmaceuticals Tevastor 10 mg papa inoa 30 - 471 mau rubles, ka mea ola e rosuvastatin, mea hana. - TEVA / TEVA PHARMA ʻike koke. kahi i kū ai mākou no ka hōʻailona. ʻO nā ikepili mai ka lāʻau lapaʻau & n.

. ^ E Ha yM. mi heluhelu a heluhelu i ka nui o nā palapala ma kēia kumuhana. Maikaʻi ʻo Rosehip i ka pā ma ka thermos i ka pō, aia ka nui o ka waiora, he mea pono ia no ka puʻuwai a me nā koko. . ^ E Ha yM. a i ka manawa mua inu lākou i nā paila, ʻānō inu mākou i ke keʻa.

Loaʻa iā mākou ʻo Plavix (ʻelua i ka lā), Krestor, Kleksan (injections), ʻaʻole wau e hoʻomanaʻo i ka koena, inu nō hoʻi ia ma ka mau lima. Plavix i ka polycl. ma Tatarstan ua hoʻololi ʻia e Zilt - a ma Moscow ua pāpā ʻia ʻo ia e inu i kahi mea hoʻohālike, no laila e inu pono i nā mea āpau - ua loaʻa iā mākou ma kahi o 20,000 mau rubles. hele aku i kēlā me kēia mahina no ka lāʻau lapaʻau.

Lawe i nā lāʻau lapaʻau Krestor lāua ʻo Tevastor, kahi ʻano e hoʻohaʻahaʻa i ka cholesterol koko ma nā mea maʻi me ka atherosclerosis. ʻO Tevastor he huaʻohana o Krestor a ua hoʻokumu ʻia ʻelua ma Rosuvastatin, ʻekolu mau manawa ʻo Tevastor a ʻaʻohe haʻahaʻa i ka mea i hele aku ai iā Krestor, akā he mau mākaʻa ia. Eia no a.

He hoʻokiʻekiʻe ʻia ʻo Cholesterol (no laila, inu pū ʻo Krestor), hoʻohaʻahaʻa ʻia i ke kaomi pinepine ma mua o 100/60 a i ʻole 110/70, e like me aʻu. ʻO ke kumu mua o ka atherosclerosis iā ia. Ua hoʻohiki ʻia ʻo Omega i hoʻokahi mahina ma mua iho, inu. Lā mea inu ʻa ka kaltsy ʻo d3 ka mea ʻono, ke manaʻo nei wau, ʻo Krestor me ka Aspirin ok?

ʻAe, e nā kaikamahine, nani au i ʻike i kēia hoʻohālikelike ʻana. ʻO wau e kākau puke. Mahalo i ka ʻike ʻike. Ua ʻae koʻu makuakāne i kahi kea a no kahi mea he mea liʻiliʻi loa ia no mākou. ʻO Jessica, a ʻaʻole maopopo iā ʻoe, hiki ke hoʻohana ʻia ʻo Tevastor i kēia manawa me ka ʻole o ke kauka lāʻau, he mea ākea loa ke ʻano o ke kumu kūʻai. A he aha ka hopena ma hope o ka noi ʻana iā Tevastor e like me ka p.

. ^ E Ha yM. Pono loa - maikaʻi loa kēia. Me he mea lā ʻaʻohe mea hewa o ka hoʻohui ʻana o kēia mau lāʻau ʻelua. Ma ka liʻiliʻi ua kuhikuhi mua ʻia au i ka atherosclerosis me vasilip a me aspirin. A i kaʻu ʻike ʻana iā ia, ke kea a me ka vasilip mai hoʻokahi ʻākena. ʻOiaʻiʻo, ʻaʻole wau i inu - ʻaʻole ka vasilip i ka lāʻau lapaʻau e hiki ai iā ʻoe ke hāpai :-)

Hoʻohana ʻia ka maikaʻi o Tevastor e like me ka Crestor. Ma hope o nā mea āpau, pono i nā lāʻau ʻelua ke ʻano rosuvastatin, akā, pono ke lawe wale ʻia ʻo ʻAnya e like me ka kauka ʻana.

Inu ʻo ia i kahi kea (tevastor). ka pale mua ʻana o nā hoʻopiʻi cardiovascular nui (hōʻeha, ka hōʻeha ʻana o ka naʻau, ka ʻokiʻoki o ka arterial) i nā maʻi pākeke me nā hōʻailona ʻole o ka maʻi coronary heart disease, akā me ka piʻi nui o kona ulu ʻana (ma luna o 50 mau makahiki no nā kāne a ʻoi aku ma luna o 60 mau makahiki he mau kāne, ua hoʻonui ʻia ʻo C-reactive ka protein (≥2 mg / l) ma mua o ka liʻiliʻi i kekahi o nā mea e pili ana i ka hopena, e like me ka arterial hypertension, haʻahaʻa haʻahaʻa o HDL-C, ulaula, ʻohana.

ʻAʻole au e maʻi. Ke heluhelu nei wau i ka ʻupena, nā like ʻole, kona kiʻekiʻe fibrinogen, a pili pū i ka makahiki. a he pilikia āpau ko mākou ma ka ʻohana. make ʻole nā kānaka a pau, a mai ka maʻi maʻi paha. ʻĀnō: (Manaʻo wau e hiki iā mākou ke hoʻohui i ka Aspirin-cardio iā Krestor? ʻAʻole i hōʻeha ʻia. ʻAʻohe make trombosis prophylaxis i loko o ka krestor. He koloa kona kiʻekiʻe a me ka atherosclerosis mua iā ia "ʻā ia.

Lapaʻau

ʻO kahi ʻaihue hypolipidemic mai ka pūʻulu o nā statins, kahi pale o HMG-CoA reductase. E like me ke kumu o ka hoʻokūkū antagonism, nā molekini statin nakinaki i kēlā hapa o ka coenzyme A receptor kahi e hoʻopili ai kēia enzyme. ʻO kekahi hapa o ka molekine statin e pale aku i ka hoʻololi ʻana o ka hydroxymethylglutarate i mevalonate, kahi kikowaena o ke kō o nā molekole kolamu. Ke hōʻike nei i ka hana o ka HMG-CoA reductase e alakaʻi i kahi ʻano o ka hopena e pili ana i ka hopena, ka hopena ma kahi o ka hoʻohaʻahaʻa ʻana i ka maʻi koloka intracellular a me ka hoʻonui ʻana i ka hana o nā mea kū i LDL a, no laila, wikiwiki ka catabolism o LDL cholesterol (Xc).

Hoʻohui ka hopena hypolipidemic o nā statins i ka hoʻemi ʻana i ka pae o ka nui o ka kolamu ma muli o ka LDL cholesterol. ʻO ka emi ʻana o LDL he hilinaʻi i ka dosis a ʻaʻole i laina, akā exponential.

ʻAʻole pili ka poʻokela i ka hana o nā lipoprotein a me nā lipula hepatic, ʻaʻole i hoʻopilikia nui i ka synthesis a me ka catabolism o nā momona momona, no laila, ʻo kā lākou hopena ma ke kiʻekiʻe o TG ma ka lua a ma ʻokoʻa hoʻi ma o kā lākou hopena nui i ka hoʻohaʻahaʻa i ka pae LDL-C. ʻO ka hoʻohaʻahaʻa iki ʻana i ka pae o TG i ka wā o ka mālama ʻana me nā statins e pili pū ana me ka hōʻike o nā koena (apo E) i loaʻa i ka papa o nā hepatocytes i komo i ka catabolism o STD, aia ma kahi o 30% TG.

I ka hopena i nā hopena lipid-lowing, ua loaʻa i nā statins ka hopena maikaʻi i ka hana endothelial (hōʻailona preclinical o ka atherosclerosis mua), ma ka paia vascular, kahi atheroma, hoʻomaikaʻi i nā waiwai rheological i ke koko, loaʻa nā antioxidant, nā waiwai antiproliferative.

Hōʻike ʻia ka hopena therapeutic i loko o hoʻokahi pule. ma hope o ka hoʻomaka ʻana o ka lapaʻau a ma hope o 2 hebedoma o ka mālama ʻana he 90% o ka hopena hiki loa i ka hopena, ka mea i loaʻa e ka 4 wiki a ma hope o ka hoʻomau mau nei.

Lapaʻau lāʻau

Ma hope o ka hoʻoponopono waha ʻana C_max Loaʻa ka plasma rosuvastatin ma kahi o nā hola 5. ʻO Bioavailability o kahi he 20%.

Hoʻopili ʻo Rosuvastatin i loko o ke akea. V_{e d} - e pili ana i 134 lita ʻO ka pilina ʻana i ka protein plasma (ʻoi loa me ka albumin) he 90%.

ʻO Biotransforms kahi liʻiliʻi (ma kahi o 10%), he papa hana non-inti no nā isoenzymes o ka pūnaehana cytochrome P₄₅₀. ^ E Ha yM. ʻO ka isoenzyme nui i komo i ka hana o ka rosuvastatin ʻo CYP2C9. ʻO Isoenzymes CYP2C19, CYP3A4 a me CYP2D6 i emi iki i ka hana metabolism.

ʻO nā metabolites nui i ʻike ʻia o ka rosuvastatin ʻo nā metabolites N-dismethyl a me ka lactone. ʻO N-dismethyl ma kahi o 50% emi iki ma mua o ka rosuvastatin, nā metabolite lactone i ka maʻemaʻe i ka hoʻouluulu.

Ma kahi o 90% o ka loaʻaʻana o ka rosuvastatin i hoʻopuka ʻia i hoʻololi ʻole ʻia me nā feces. Hoʻokuʻu ʻia ke koena i loko o ka mōʻai. ʻLelo T_1/2 - aneane 19 hola T_1/2 ʻaʻole e loli me ka hoʻonui ʻana i kahi wai. ʻO ka hoʻomaʻemaʻe ʻana o ka plasma awelika he 50 l / h (ka coefficient o ka ʻano 21.7%).

E like me ka poʻe ʻē aʻe o ka pale o HMG-CoA-reductase, ua hoʻokomo aku ka membrane Xc i ka uppake hepatic o rosuvastatin, ka mea nui i ka hana hepatic o ka hoʻohemo ʻana o ka rosuvastatin.

Hoʻonui ka ʻōhumu o ka rosuvastatin i ka hoʻohālikelike i ka nui.

I nā maʻi āpau me nā pilikia ʻole pepeha (QC āpau

Kahiana Koho

Nā māku e like me nā hōʻike

ʻO ke kumukūʻai mai 54 mau rubles. ʻOi aku ka maʻalahi o ka analogue ma ka 606 mau rubles

Nā māku e like me nā hōʻike

Kumukūʻai mai 324 mau rubles. ʻOi like ka analogi ma ka 336 mau rubles

Nā māku e like me nā hōʻike

ʻO ke kumukūʻai mai 345 rubles. ʻOi like ka analogi ma ka 315 mau rubles

Nā māku e like me nā hōʻike

ʻO ke kumukūʻai mai 369 rubles. ʻOi like ka analogi ma ka 291 mau rubles

Nā māku e like me nā hōʻike

ʻO ke kumukūʻai mai 418 mau rubles. ʻOi like ka analogi ma o 242 mau rubles

Nā māku e like me nā hōʻike

ʻO ke kumu kūʻai mai ka 438 mau rubles. ʻOi like ka analogi ma ka 222 mau rubles

Nā māku e like me nā hōʻike

He kumukūʻai ke kumukūʻai mai 604 rubles. ʻO ka analogi ka mea kūʻai loa ma ka 56 mau rubles

Nā māku e like me nā hōʻike

Kumukūʻai mai 737 mau rubles. Ua ʻoi aku ka uku o ka analogue ma ka 77 mau rubles

Nā māku e like me nā hōʻike

ʻO ke kumukūʻai mai 865 rubles. Ua ʻoi aku ka kumu o ka analogue ma mua o 205 mau rubles

Nā palapala ʻano:

Aia i kēlā me kēia papa he waiwai ikaika. rosuvastatin 10, 20 a 40 mg paha ma ke ʻano o ka calcium rosuvastatin.
Nā mea hoʻoweliweli: lactose monohidrat 89.50 mg (no ka lō o 10 mg), 179.00 (no ka laʻana o 20 mg), 164.72 mg (no kahi kuana o 40 mg), cellulose microcrystalline 29.82 mg (no kahi ala o 10 mg), 59.64 mg (no ka lō ʻana o 20 mg), 54.92 mg (no kahi ala o 40 mg), ka calcium o ka phosphate 10,90 mg (no ka laʻana o 10 mg), 21.80 mg (no kahi ala o 20 mg), 20.00 mg (no kahi ala 40 mg), crospovidone 7.50 mg (no ke kaena o 10 mg), 15.00 mg (no ka laʻana o 20 mg), 15.00 mg (no kahi kuʻi o 40 mg), ka pākuʻi o ka magnesium 1.88 mg (no kahi ala o 10 mg) 3.76 mg (no kahi pākaukau o 20 mg), 3.76 mg (no kahi kaila o 40 mg), papa pālani: lactose monohilohi 1.80 mg (no ka lō o 10 mg), 3.60 mg (no ka laʻana o 20 mg), 3.60 mg (no kahi kuana o 40 mg), hypromellose 1.26 mg (no kahi ala o 10 mg), 2.52 mg (no ka helu o 20 mg), 2.52 mg (no kahi ala o 40 mg), triacetin (glycerol triacetate) 0.36 mg (no kahi ala o 10 mg), 0.72 mg (no kahi ala o 20 mg), 0.72 mg (no ka dosage o 40 mg), ka titanium dioxide 1.06 mg (no kahi ala o 10 mg), 2.11 mg (no kahi inumana o 20 mg), 2.11 mg (no kahi ala o 40 mg), ka hao dye oxide ulaula 0.02 mg (no ka pāʻālua o 10 mg), 0,05 mg (no ka lō o 20 mg), 0,05 mg (no ke kaena o 40 mg).

ʻO keʻano

Nā papa papaʻaila 10 mg: mau hāmeʻe, papa biconvex, i kālai ʻia me ka membrane kiʻi ʻoniʻoni, i kahakaha ʻia me "ZD4522 10" ma kahi ʻaoʻao.
Nā papa 20 mg: nā papa biconvex a puni, i kāwili ʻia me ka membrane kiʻi ʻulaʻula, i kahakaha ʻia me "ZD4522 20" ma kahi ʻaoʻao.
Nā papa 40 mg: oval, nā biconvex tablet, i uhi ʻia me ka membrane kiʻi pink, i kahakaha ʻia me "ZD4522" ma kekahi ʻaoʻao a he 40 ma ka ʻaoʻao ʻē aʻe.

ʻO nā waiwai Pharmacological

Nā hana hana i ka hana
ʻO Rosuvastatin kahi mea koho hemahema, mea hoʻokūkū o ka HMG-CoA reductase, he enzyme e hoʻololi ana i ka 3-hydroxy-3-methylglutaryl coenzyme A i mevalonate, kahi mua kolesterol. ʻO ka pahuhopu nui o ka hana a rosuvastatin ka ate, kahi i lawe ʻia ai ka synthesis o ka cholesterol (kolesterol) a me ka catabolism o nā lipoproteins low density (LDL).
Hoʻonui ʻo Rosuvastatin i ka nui o nā ʻĀpana LDL ma ka ʻaoʻao o ke kelepona, e hoʻonui ana i ka hiʻona a me ka catabolism o LDL, a me ka huli ʻana i ka pale ʻana o ka syntoproteins haʻahaʻa haʻahaʻa haʻahaʻa (VLDL), a laila e hōʻemi ana i ka nui o ka nui o ka LDL a me VLDL.

Lapaʻau lāʻau
Hoʻololi ʻo Krestor ® i ka hoʻokiʻekiʻe ʻana o ka LDL cholesterol (cholesterol-LDL), ka nui o ka kolamu, triglycerides (TG), e hoʻonui i ka pae o ka lipoprotein cholesterol kiʻekiʻe (HDL-C), a me ka hoʻohaʻahaʻa hoʻi i ka paʻa ʻana o ka apolipoprotein B (ApoV), ʻaʻole cholesterol HDL. -LVONP, TG-VLDLP a hoʻonui i ka kealike o ka apolipoprotein AI (ApoA-I) (e ʻike i nā papaʻaina 1 a me 2), e hōʻemi ana i ka pae o LDL-C / HDL-HDL, ka nui kolesterol / HDL-C a me HDL-C / HDL-C a me ApoB / ApoA-I ratio.
Hoʻokomo ka hopena therapeutic i loko o hoʻokahi pule ma hope o ka hoʻomaka ʻana o ka hopena me Krestor ®, ma hope o ka 2 mau pule o ka lapaʻau i hōʻea ʻo 90% o ka hopena hiki loa.
Loaʻa ka hopena olakino kiʻekiʻe loa e ka hopena o ka wiki 4 ma ka mālama ʻia a mālama ʻia me ka hoʻohana maʻamau ʻana i ka lāʻau.

Papa Hana 1 . ^ E Ha yM. Hoʻololi ka hopena o ka maʻi ma ka maʻi me nā hypercholesterolemia mahele (type IIa a me IIb e like me Fredrickson) (ka hoʻololi ʻia o ka hopena pākēneka i hoʻohālikelike ʻia i ka waiwai mua).

Dosis	Qty o nā maʻi	HS-LDL	Kālā kolamu	HS-HDL	TG	ʻO kahi HS-hema-HDL	ApoV	ApoA-I
Placebo	13	-7	-5	3	-3	-7	-3	0
10 mg	17	-52	-36	14	-10	-48	-42	4
20 mg	17	-55	-40	8	-23	-51	-46	5
40 mg	18	-63	-46	10	-28	-60	-54	0

Papaʻaʻina 2 . ^ E Ha yM. Hoʻololi ka hopena o ka maʻi ma ka maʻi me nā hypertriglyceridemia (type IIb a me IV e like me Fredrickson) (ka hoʻohalikeʻana o ka loli pākēneka i hoʻohālikelike ʻia i ka waiwai mua).

Dosis	Qty o nā maʻi	TG	HS-LDL	Kālā kolamu	HS-HDL	ʻO kahi HS-hema-HDL	HS-VLDLP	TG-lponp
Placebo	26	1	5	1	-3	2	2	6
10 mg	23	-37	-45	-40	8	-49	-48	-39
20 mg	27	-37	-31	-34	22	-43	-49	-40
40 mg	25	-43	-43	-40	17	-51	-56	-48

Maikaʻi ʻoiaʻiʻo He mea kūpono ia ʻo Krestor ® i ka poʻe maʻi maʻi me ka hypercholesterolemia me ke ʻano ʻole o ka hypertriglyceridemia, me ka manaʻo o ka iwi, ka ʻenemi a i ʻole ka makahiki, ʻo nā mea maʻi me ka maʻi mellitus a me ka hypercholesterolemia familial. I ka 80% o nā maʻi me ka type IIa a me IIb hypercholesterolemia e like me Fredrickson (ʻo ka ʻōpū maʻamau o ka LDL-C ma kahi o 4.8 mmol / L), ʻoiai e lawe ana i ka lāʻau lapaʻau ma kahi o 10 mg, ʻoi ka ʻike o LDL-C i hōʻemi ma mua o 3 mmol / L.
I ka maʻi me ka heterozygous hypercholesterolemia famili e loaʻa Krestor ® ma ke ʻano o 20-80 mg, ua nānā maikaʻi ʻia ka dinamika o ka ʻōlelo lipid (aʻo e pili ana i nā maʻi 435). Ma hope o ka titration i ka pākahi o kēlā me kēia lā he 40 mg (12 mau wiki o ka hoʻouluʻana i ka maʻi), ʻike ʻia kahi emi o ka hiki ʻana o LDL-C ma ka 53%. Ma 33% o nā maʻi, ua loaʻa kahi LDL-C i hōʻemi ʻia ma lalo o 3 mmol / L i loaʻa.
I ka poʻe maʻi me ka hypercholesterolemia homozygous e lawe ana iā Krestor ® ma ke ʻano o 20 mg a me 40 mg, ka nui o ka hōʻemi ma waena o ka loaʻa ʻana o LDL-C he 22%.
I ka poʻe maʻi me ka hypertriglyceridemia me ka makaʻi mua o TG mai 273 a 817 mg / dl i loaʻa iā Krestor ® ma loko o kahi pākaʻi o 5 mg a 40 mg hoʻokahi manawa i hoʻokahi lā he 6 mau pule, ua hoʻemi nui ʻia ka manaʻo o TG ma ka lolo koko (me ka papa ʻaina 2 )
Hoʻomaopopo ka hopena hoʻohui me ka fenofibrate i pili i ka nānā ʻana o ka triglycerides a me ka hoʻōla molotinik ma nā lipid e hoʻohaʻahaʻa i nā hāmeʻe e pili ana i ka neʻe o HDL-C (e nānā pū i ka ʻāpana "Kūlana Kūlana").
Ma kahi noiʻi METEOR ma 984 nā mea maʻi me 45-70 mau makahiki me ka haʻahaʻa haʻahaʻa o ka hoʻomohala ʻana i ka maʻi naʻau coronary (CHD) (10 makahiki ka pilikia o ka Framingham haʻahaʻa ma mua o 10%), kahi awelika LDL cholesterol kiʻekiʻe o 4.0 mmol / L (154.5 mg / dl) a me atherosclerosis subclinical (i loiloi ʻia e ka mānoanoa o ka carotid artery intima-media complex - TCIM) i ʻike i ka hopena o ka rosuvastatin ma ka mānoanoa o ka hoʻopili intima-media. Loaʻa nā mea maʻi i ka rosuvastatin ma kahi pānaʻi o 40 mg / lā a i ʻole placebo no 2 mau makahiki.
Ua lohi nui ka lāʻau Rosuvastatin i ka piʻi ʻana o ka nui o TCIM no ka 12 mau ʻāpana o ka ʻenekene carotid i hoʻohālikelike ʻia me ka placebo me ka hoʻokaʻawale ʻana o -0.0145 mm / makahiki 95% ka pilina manawa mai -0.0196 a -0.0093, ʻaʻole ke ʻāpono ʻia nā pX 40 mg. Pono ke ʻano o 40 mg e hoʻohana ʻia i nā mea maʻi me ka hypercholesterolemia koʻikoʻi a me kahi koʻikoʻi nui o nā maʻi cardiovascular (CVD).
Nā hualoaʻa o ka noi ʻana ʻo JUPITER (ʻO ka hoʻomaʻamaʻa ʻana no ka hoʻohana ʻana o statins no ka pale mua ʻana: he ʻano noiʻi loiloi ʻo ka loiloi iā rosuvastatin) i 17802 nā mea maʻi i hōʻike mai ua hōʻemi nui ʻia ʻo rosuvastatin i ka hōʻeha o ka hoʻopiʻi cardiovascular (252 i ka hui pletebo i hoʻohālikelike ʻia me 142 i ka hui ʻo rosuvastatin) (p ma hope o nā malama 6 mua o ka hoʻohana ʻana i ka lāʻau, aia ka hōʻemi nui o ka nui o 48% i loko o ka waihona hoʻohui, me ka make hoʻi mai nā kumu cardiovascular, insulin m + a myocardial infarction (p ÷ ino hiʻohiʻona: 0,52, 95% hilinai wā mawaena 0,40-0,68, pa ® i na keiki ma lalo o makahiki 18 makahiki.

ʻO nā maʻi me ka palaualohi maʻa
ʻAʻohe ʻikepili a i ʻole ka ʻike me ka hoʻohana ʻana i ka lāʻau lapaʻau i ka poʻe maʻi me ka helu ʻoi aku ka kiʻekiʻe ma 9 ma ke kiʻekiʻe o ke keiki-Pugh (e nānā i nā ʻāpana "Pharmacodynamics" a "Nā Kūlana Kūʻai").

ʻLoe a me ke kākele

I loko, ʻaʻole e pihi a kīwī paha i ka papa papa, ʻūlū holoʻokoʻa, holoi ʻia me ka wai. Hiki i ke lāʻau lapaʻau ke kuhikuhi i kēlā me kēia manawa o ka lā, me ka mālama ʻole o ka meaʻai.
Ma mua o ka hoʻomaka ʻana i ka mālama ʻana me Krestor ®, pono e hoʻomaka ka mea maʻi e hahai i ka ʻai maʻamau hypocholesterolemic a me ka hoʻomau e hahai i ia i ka wā e mālama ai. Pono ke koho ʻia o ka hopena o ka lāʻau ke kū hoʻokahi i nā pahuhopu o ka hoʻōla a me ka pane ʻana i ka therapeutic i ka mālama ʻana, me ka noʻonoʻo ʻana i nā loiloi o kēia manawa i ka huli ʻana o ka lipids.
ʻO ka papa hoʻomaka ʻana i nā maʻi e hoʻomaka ana e lawe i ka lāʻau lapaʻau, a no nā mea maʻi i hoʻihoʻi ʻia mai ka lawe ʻana i nā HMG-CoA reductase inhibitors, pono ʻia he 5 a 10 mg paha o Krestor ® i hoʻokahi lā. Ke koho ʻana i kahi pualikoa mua, pono e alakaʻi ʻia e ka mea maʻi o ka lāʻau hoʻokahi a e noʻonoʻo i ka hiki i ke ʻano o ka hōʻemi o nā ʻōkuhi cardiovascular, a he mea pono no hoʻi e nānā i ka hopena kūpono o ka hopena o ka hopena. Inā kūpono, hiki ke hoʻonui ʻia ka momona i ka nui ma hope o nā hebedoma 4 (e ʻike i ka ʻāpana "Pharmacodynamics").
I ka pilina me ke hiki paha i ka hopena o nā hopena ʻaoʻao ke kaomi ʻana o ka nui o 40 mg, hoʻohālikelike ʻia me nā haʻahaʻa haʻahaʻa o ka lāʻau (e ʻike i ka ʻāpana "ʻaoʻao effects"), e hoʻonui ana i ka maʻi ma ka 40 mg ma hope o ka nui o ka hopena hou aʻe ma mua o ke ʻano i ʻōlelo ʻia no nā wiki he 4. hiki ke hoʻokola wale ʻia ʻo ia i nā maʻi me nā maʻi hypercholesterolemia koʻikoʻi a me ke koʻikoʻi o nā maʻi cardiovascular (ʻoi aku hoʻi i nā poʻe maʻi me ka hypercholesterolemia familial) ʻaʻole i loaʻa i ka hopena makemake e loaʻa ai ka hopena i ka wā e lawe ai i ka pā 20 mg, a ʻo wai lā e makemake ai? ia ma lalo o hoʻomalu hooponopono (e nānā. "Special Na Ke Kumu" pauku).
ʻAno ke kiaʻi ʻana i ka poʻe maʻi e loaʻa i ka lāʻau lapaʻau ma loko o kahi mīkala o 40 mg.
ʻAʻole kuhikuhi ʻia kahi dosage 40 mg no nā maʻi ʻaʻole i kūkākūkā ma mua i kahi kauka.
Ma hope o 2 mau hebedoma e pili ana i ka mālama ʻana a me / a me ke hoʻonui ʻana o ka nui o ka mahele o ka hoʻomākaukau ʻana o Krestor ®, ka nānā ʻana o ka lipid metabolism e pono (pono ʻia ka hoʻoponopono ʻana inā pono).

ʻO nā maʻi maʻi
ʻAʻole pono ke hoʻoponopono ʻia.

ʻO nā mea maʻi me ka maikaʻi ʻole o ka pūpū
I nā mea maʻi me ka hōʻemi ʻole ʻana a me ka hoʻololi ʻole, ʻaʻole i koi ʻia ka hoʻoponopono ʻana. I ka poʻe maʻi me ka hōʻeha kino ʻole (CC ma mua o 30 ml / min.), Ua contraindicated ka hoʻohana ʻana o ka lāʻau Krestor ®.
ʻO ka hoʻohana ʻana i ka lāʻau lapaʻau i loko o kahi waihona o 40 mg ua contraindicated i loko o nā mea maʻi me ka hana o ka renal i ke kino (CC ma mua o 30-60 ml / min.) (E nānā i ka ʻāpana "Nā Manaʻo Manaʻo" a me "Pharmacodynamics"). No ka poʻe maʻi me ka hana renal moderate, kahi paipai o ka hoʻomakaʻana o 5 mg.

ʻO nā maʻi me ka palaualohi maʻa
Ua hoʻohele ʻia ʻo Krestor ® i ka poʻe maʻi me ka maʻi o ka ate ma ka mahele ikaika (ʻike i ka ʻāpana "Contraindications").

Nā iwi kūikawā. Nā hui ʻano
Ke aʻo nei i nā lāʻau lapaʻau pharmacokinetic o rosuvastatin i nā poʻe maʻi e pili ana i nā ʻano like ʻole o ka iwi, ua ʻike nui ʻia ka nui o ka ʻōnaehana o ka rosuvastatin ma waena o Iapana a me ka Kina. (ʻIke i ka ʻāpana "Kūlana Kūlana"). Pono e noʻonoʻo ʻia kēia ʻoiaʻiʻo i ka wā e kuhikuhi ai iā Krestor ® i kēia mau mea maʻi. I ka hoʻomaka ʻana i nā pona o ka 10 a me 20 mg, ʻo ka pona i hoʻomaka ʻia no nā poʻe maʻi o ka lāhui Mongoloid he 5 mg. Ua hoʻohālikelike ka hoʻomalu o ka lāʻau lapaʻau ma ke ʻano he 40 mg no ka poʻe maʻi o ka lāhui Mongoloid (e ʻike i ka ʻāpana "Contraindications").

Hoʻolaha ka genetic polymorphism
ʻO nā mea lawe aku i nā genotypes SLC01B1 (OATP1B1) c.521CC a me ABCG2 (BCRP) c.421AA i hōʻike i ka hoʻonui ʻana i ka hoʻolaha (AUC) i ka rosuvastatin hoʻohālikelike i nā mea lawe o nā genotypes SLC01B1 c.521TT a me ABCG2 c.421CC. No nā mea maʻi e lawe ana i ka genotypes c.521CC a c.421AA, ʻo ka nui loa ke kuhi ʻia ʻana o Crestor ® ka 20 mg hoʻokahi i kēlā lā i kēia lā (e ʻike i nā ʻāpana "Pharmacokinetics", "Nā Kūlana Kūlana" a "Hoʻohui ʻia me nā lāʻau lapaʻau a me nā ʻano ʻē aʻe o ka Hoʻohui Kūleʻa" )

ʻO nā maʻi maʻi Myopathy-prone
ʻO ka lawelawe o ka lāʻau lapaʻau ma kahi maʻa o 40 mg i contraindicated i loko o nā mea maʻi me nā mea e hōʻike ana i kahi predisposition i ka hoʻomohala ʻana i ka myopathy (e ʻike i ka ʻāpana "Contraindications"). I ka hoʻonoho ʻana i nā wai o 10 a me 20 mg, ʻo ka ʻōmomi i hoʻomaka ʻia no kēia pūʻulu o nā maʻi ka 5 mg (E nānā i ka ʻāpana "Contraindications")

Hoʻolālā hoʻohui
Hoʻopili ʻo Rosuvastatin i nā ʻōmole lele lele (ma ka nui, OATP1B1 a me BCRP). Ke hui pū ʻia me Krestor ®, me nā lāʻau lapaʻau (e like me ka cyclosporine, kekahi mau proteides inhibitor, me ka hui pū ʻana o ritonavir me ka atazanavir, lopinavir a me / a tipranavir), e hoʻonui ai i ka manaʻo o ka rosuvastatin i ka plasma ma muli o ka hoʻopili me ka hoʻouka ʻana i ka halihali. rhabdomyolysis) (ʻike i nā ʻāpana "Kūlana kūikawā" a "Hoʻohui ʻana me nā lāʻau ʻē aʻe a me nā ʻano lāʻau ʻē aʻe". Pono ʻoe e heluhelu i nā ʻōlelo kuhikuhi no ka hoʻohana ʻana i kēia mau lāʻau ma mua o kā lākou koho i hui pū ʻia me ka lāʻau lapaʻau ʻana ʻo Krestor ®. I nā hihia ʻē aʻe, pono ʻoe e loiloi i ka pono o ke koho ʻana i nā lāʻau lapaʻau ʻē aʻe a i ʻole ke hoʻokaʻawale i ka hoʻohana ʻana i ka lāʻau Krestor ®. Inā kupono ka hoʻohana ʻana o nā lāʻau lapaʻau ma luna, pono e loiloi i ka pae o ka maikaʻi a me ka hōʻemi o ka hālāwai concomitant me ka lāʻau lapaʻau Crestor ® a e noʻonoʻo i ka hiki ke hōʻemi i kona ʻāʻī (e ʻike i ka ʻāpana "Hoʻohui me nā lāʻau ʻē aʻe a me nā ʻano like ʻole o ka hoʻopili o ka lāʻau").

Loaʻa ka hopena

Hoʻomaʻamaʻa nā ʻaoʻao ʻaoʻao i ka wā e lawe ʻia ai ka lāʻau Krestor ® mau maʻamau a haʻalele iā lākou iho. E like me nā HMG-COL reductase inhibitors, ʻo ka pohō o nā hopena ʻokoʻa, ʻo ia nō ka hilinaʻi nui.
Ua hōʻike ʻia ke ʻano o nā hopena ʻino e like me kēia:
pinepine (> 1/100, 1/1000, 1/10000, ®, ʻike ʻia ka proteinuria. Hiki ke ʻike ʻia nā loli i ka nui o ka protein i loko o ka urine (mai ka ʻole a i ʻole ke ʻano he nui a ++ a keu paha) ʻike ʻia ma ka liʻiliʻi o 1% o nā mea maʻi e loaʻa ana he 10-20 mg. ka lāʻau lapaʻau, a ma kahi o 3% o nā maʻi e loaʻa ana i ka 40 mg o ka lāʻau.
Ua nānā iki ʻia kahi hoʻololi o ka nui o ka nui o ka protein i ka urine i ka wā e lawe ai i ka pāʻauʻau he 20 mg. I ka nui o nā hihia, hōʻemi a nalowale paha proteinuria i ka wā o ka noʻonoʻo a ʻaʻole ia e manaʻo i ka hoʻomaka ʻana o nā maʻi a mālama paha i ka maʻi ʻōnaehana.
Mai ka ʻōnaehana musculoskeletal
Ke hoʻohana ʻia nei ka lāʻau Krestor ® i loko o nā āpau āpau, a keu hoʻi inā ka lawe ʻana i nā kaona o ka lālau ma mua o 20 mg, ua hōʻike ʻia nā hopena e pili ana i ka ʻōnaehana musculoskeletal: myalgia, myopathy (me kaʻu myositis), ma nā hihia lohi, rhabdomyolysis me i ʻole me ka hoʻomaʻomaʻi ʻole ʻana i ka maʻi renal. iā ia.
Hoʻonui ʻia ka nui o ka hopena i ka hana o ka phosphokinase (CPK) i ʻike ʻia i kekahi helu liʻiliʻi o nā maʻi e lawe ana i ka rosuvastatin. I ka hapa nui, he mālie, asymptomatic a me ka wā lewa. I ka hihia o ka hana o ka CPK (ʻoi aku ʻo 5 mau manawa i hoʻohālikelike ʻia me ke palena palena o ka maʻamau), pono e hoʻokuʻu ʻia ka lāʻau maʻi (e ʻike i ka ʻāpana "Nā Kūlana Kūʻai").
Mai ka leʻa
I ka hoʻohana ʻana i ka rosuvastatin, he hoʻonui ʻia ka hilinaʻi nui ma ka hana o nā "transaminases" hoʻomaʻamaʻa ʻia i nānā ʻia ma ka helu liʻiliʻi o nā maʻi. I ka nui o nā hihia, he waiwai ʻole ia, asymptomatic a me kahi wā pōkole.
Nā hōʻailona hana hana
I ka hoʻohana ʻana o ka hoʻomākaukau ʻana o Krestor ®, ua nānā ʻia nā loli o ka hoʻololi ʻana i nā kūmole: kahi hoʻonui i ka hoʻoliʻi o ka glucose, bilirubin, ka hana a gamma-glutamyl transpeptidase, alkaline phosphatase, a me ka hoʻōki o thyroid.

Kauhai-noi noi
ʻO nā hopena pili aʻe, ua hōʻike ʻia ma ka hoʻohana ʻana ma hope o ke kūʻai ʻana ma Krestor ®:
Mai ka ʻōnaehana hematopoietic
Ka hōʻailona i kikoo ʻole: thrombocytopenia
Mai ka huehue wai ʻana
Loaʻa loa: jaundice, hepatitis
Kūkākūkaha: piʻi nui ka hana o nā transaminases "ʻili"
He kīnā ʻole: ʻike ʻole
Mai ka ʻōnaehana musculoskeletal
ʻAʻole loa: arthralgia
Hua'ōlelo i hoʻokaʻawale ʻole: immuno-mediated necrotizing myopathy
Mai ka pūnaehana neʻe i waena
Loaʻa loa: nalowale hoʻomanaʻo a nalowale paha
ʻO ka alapine hiki ʻole: peripheral neuropathy
Mai ka papa huhū
Ka leo i ʻike ʻole ʻia: umauma, pōkole o ka hanu
Mai ka pūnaehana urinary
Nui loa: hematuria
Ma ka ʻāpana o ka ʻili a me nā momona subcutaneous
Kākau i hoʻokaʻawale ʻia: nā maʻi ʻo Stevens-Johnson
Mai ka ʻōnaehana hana nui a me ka papa momona mumm
ʻO nā kikoʻī i hoʻopuka ʻole ʻia: gynecomastia
ʻO kekahi
Kālā i ʻike ʻole ʻia: edema peripheral

I ka hoʻohana ʻana i kekahi statins, ua hōʻike ʻia nā hopena like ʻole:
ʻO ke kaumaha, nā hana hiamoe, a me ka moeʻuhane a me ka "moemoeā" moeʻuhane, hana kūpono i ka maʻi, hyperglycemia, hoʻonui nui ʻia o ka hemoglobin glycosylated.
Ua hōʻike ʻia nā hihia ʻoiola o ka maʻi umauma interstitial, ʻoi aku ka nui o ka hoʻohana ʻana i nā lāʻau lapaʻau (e ʻike i ka ʻāpana "Nā ʻōlelo kikoʻī".

Ke keu

Me ka mālama like ʻana o nā dosa i kēlā me kēia lā, ʻaʻole e loli ka nui o ka pharmacokinetic o ka rosuvastatin.
ʻAʻohe mālama kūikawā no ka overdose o rosuvastatin. I ka hihia o ka overdose, ua hāpai ʻia e hoʻokō i ka mālama maʻi a me nā ana i nānā i ka mālama ʻana i nā hana o nā lālā nui a me nā ʻōnaehana. Pono ka nānā ʻana i nā hana kāpili a me nā pae kiʻekiʻe o CPK. ʻAʻole makemake ʻia ka Hemodialysis.

Hoʻopili me nā hua lāʻau ʻē aʻe a me nā ʻano lāʻau ʻē aʻe o ka launa ʻana

ʻO ka hopena o ka hoʻohanaʻana i nā lāʻauʻokoʻa'ē aʻe ma rosuvastatin
Nā mea hōʻike o nā ʻōkuhi huakaʻi: Hoʻopili ka rosuvastatin i kekahi mau ʻōmua o ka halihali, ʻoiai, OATP1B1 a me BCRP. ʻO ka hoʻohana mau ʻana i nā lāʻau lapaʻau e ʻāpono i kēia mau ʻōmaʻa o ka huakaʻi, e hele pū ʻia me ka nui o ka neʻe ʻana o ka plasma o rosuvastatin a me ka nui o ka piʻi ʻana o ka myopathy (e ʻike i ka papa 3 a me nā pauku "Dosage a me ka hoʻokele" a "Nā ʻōlelo aʻoaʻo kūikawā)).
Lualope: me ka hana like o rosuvastatin a me ka cyclosporine, ʻo AUC o ka rosuvastatin ma ka nui he 7 mau kiʻekiʻe ma mua o ka mea i ʻike ʻia i nā mea hana olakino (e ʻike i ka papa 3). ʻAʻole pili i ka pili o ka plasma o ka cyclosporine. Krestor ® contraindicated i nā maʻi e lawe ana i ka cyclosporine (e ʻike i ka ʻāpana "Contraindications").
Human Immunodeficiency Virus (HIV) protease pale: ʻoiai ʻaʻole maopopo ka ʻike maoli o ka launa, ʻo ka hoʻokele ʻana o ka inhibitor o ka protease HIV i hiki ke alakaʻi i ka nui nui o ka hoʻolaha ʻana i ka rosuvastatin (e ʻike i ka papa 3).
Ke noiʻi nei ʻo pharmacokinetic o ka hoʻohana like ʻana o 20 mg o rosuvastatip me ka hoʻomākaukau hui pū ʻana e loaʻa ana ʻelua ʻelua ka protease inhibitor (400 mg o lopinavir / 100 mg o ritonavir) i nā mea hana olakino olakino i alakaʻi ʻia i kahi mahinahua a me ʻelima mau pāhina i AUC (0-24) a me Cmax o rosuvastatin, ma kēlā. No laila, ʻaʻole i kauoha ʻia ka lawelawe like ʻana o ka rosuvastatin a me ka HIV protease inhibitoria (e nānā i nā ʻāpana "Dosage and Administration", "Manaʻo Manaʻo", papa 3).
ʻO Gemfibrozil a me nā lāʻau hou lipid-hoʻokuʻu i lalo. ka hui pū ʻana o rosuvastatin a me gemfibrozil e alakaʻi i kahi hoʻomehana 2-pilipoi i ka ʻike nui o ka rosuvastatin i loko o ke kō koko plasma a me ka AUC o rosuvastatin (e nānā i ka ʻāpana "Nā ʻōlelo aʻoaʻo") Ma muli o nā ʻikepili e pili ana i nā hōʻiliʻili pilikino, ʻaʻole i manaʻo ʻia nā mea pili nui o ka pharmacokinetically me ka fenofibrate, hiki i nā mea lapaʻau pharmacodynamic.
ʻO Gemfibrozil, fenofibrate, nā fibrates ʻē aʻe, a me nā lipid-hoʻohaʻahaʻa i ka wai momona nikotinic i hoʻonui i ka hopena o ka myopathy i ka wā i hoʻohana pū ʻia me HMG-CoA reductase inhibitors, hiki paha ma muli o ka hiki ke hoʻomau i ka myopathy i ka wā i hoʻohana ʻia ai i ka monotherapy (e ʻike i ka ʻāpana "Kūlana Kūlana") . ^ E Ha yM. ʻOiai e lawe ana i ka lāʻau lapaʻau me gemfibrozil, fibrates, nicotinic acid ma ka lipid e hoʻohaʻahaʻa i nā wai (ʻoi aku ka nui o ka 1 g / lā), ua hoʻolako ʻia nā mea maʻi me kahi hoʻomaka o 5 mg, kahi maʻi o 40 mg e hoʻohālikelike ʻia me ka fibrates (e ʻike i nā ʻāpana "Contraindications", " ʻO ka palapala a me ka hoʻokele "," Nā ʻōlelo aʻoaʻo kūikawā ").
Ezetimibe: ka manawa like o ka lāʻau Krestor ® ma ka maʻa o 10 mg a me ezetimibe ma ke kūkaʻa o 10 mg i mālama ʻia me ka piʻi ʻana o AUC o rosuvastatin i nā mea maʻi me ka hypercholesterolemia (e ʻike i ka papaʻaina 3). ʻAʻole hiki ke hoʻokaʻawale i ka nui o nā hopena o ka hopena ma muli o ka hoʻopili apopo ʻo ka maʻi pharmacodynamic ma waena o ka lāʻau Krestor ® a me ka ezetimibe.
ʻĀpono: ka hana like o rosuvastatin a me nā pohō o nā antacids e loaʻa ana i ka magnesium a me ka alumini hydroxide, alakaʻi i kahi emi iki o ka plasma o ka rosuvastatin e pili ana i 50%. Hōʻike ʻia kēia hopena inā hoʻohana ʻia nā antacids i mau hola 2 ma hope o ka lawe ʻana i ka rosuvastatin. ʻAʻole i aʻo ʻia ka maʻi koʻikoʻi o kēia pilina.
Erythromycin: ka manawa like o ka rosuvastatin a me ka erythromycin i kahi hōʻemi i ka AUC o rosuvastatin e 20% a me Cmax o ka rosuvastatin e 30%. Hiki i kēlā hōʻiliʻili ʻano hopena ma muli o ka nui o ka motility intestinal i kumu e ka hoʻokomo ʻana o ka erythromycin.
Isofermeitis Cytochrome P450: Hōʻike nā hualoaʻa ma vivo a me nā haʻawina in vitro no ka rosuvastatin ʻaʻole ia he mea pale a ʻaʻole i kekahi mea hoʻoikaika o isoenzymes o ka cytochrome P450. Eia kekahi, ʻo ka rosuvastatin kahi palupalu palupalu no kēia isoenzymes. No laila, ʻaʻole e kali ʻia ka pilina o nā rosuvastatin me nā lāʻau ʻē aʻe ma ka metabolic level e pili ana i ka isoenzymes cytochrome P450.
ʻAʻohe hui lapaʻau koʻikoʻi o rosuvastatin me fluconazole (kahi mea paʻa o ka isoenzymes CYP2C9 a me CYP3A4) a me ketoconazole (kahi mea paʻa o ka isoenzymes CYP2A6 a me CYP3A4).
ʻO ka pālula Fusidic: nā haʻawina e noiʻi i ka hoʻopili ʻana o ka rosuvastatin a me ka waikawa fusidic ʻaʻole i hana. E like me nā statins ʻē aʻe, ua loaʻa nā lula post-marketing o rhabdomyolysis me ka hoʻokele waiwai o ka rosuvastatin a me ka waikawa fusidic. Pono pono e kiaʻi pono i nā maʻi. Inā pono, hiki ke hoʻokaʻawale kahi manawa o ka rosuvastatin.

ʻO ka pilina me nā lāʻau lapaʻau e pono ai i ka hoʻoponopono ʻana o ka rosuvastatin (e ʻike i ka papa 3)
Hoʻoponopono ʻia ke ʻano o ka lāʻau ʻo Krestor ® inā pono, ʻo kona hoʻohui pū ʻana me nā lāʻau e hoʻonui ai i ka ʻike iā rosuvastatin. Pono ʻoe e heluhelu i nā ʻōlelo kuhikuhi no ka hoʻohana ʻana i kēia mau lāʻau ma mua o kā lākou koho i hui pū ʻia me ka lāʻau lapaʻau ʻana ʻo Krestor ®. Inā hoʻonui ka hoʻonui i ka manawa o 2 mau manawa a i ʻole e manaʻo ʻia, pono ka hopena mua o ka hoʻomākaukau ʻana no Crestor ® i ka 5 mg hoʻokahi i ka lā. Pono ʻia ka lōʻihi o kēlā me kēia lā ʻo Krestor ® e hiki i ka hoʻonui ʻia ʻana o ka rosuvastatin no ke koena no 40 mg ka mea i loaʻa ʻole me ka hoʻomohala mau ʻana o nā lāʻau lapaʻau e pili pū ana me rosuvastatin. No ka laʻana, ʻo ka nui o ka nui o kēlā me kēia lā o ka lāʻau Crestor ® me ka hoʻohana like ʻana me ka gemfibrozil he 20 mg (ka nui o ka hoʻolaha ʻana ma o nā manawa he 9,9), me ka ritonavir / atazanavir - 10 mg (hoʻonui i ka hoʻolaha ʻana he 3.1 mau manawa).

Papa Kiʻina 3 . ^ E Ha yM. ʻO ka hopena o ka hopena concomitant ma ka hoʻolaha ʻana i ka rosuvastatin (AUC, e hōʻike ʻia nei nā hōʻike i ka hoʻemi ʻana i nā ʻoihana) - nā hopena o nā hoʻokolohua lapaʻau i paʻi ʻia.

Hāloa pili nā maʻi maʻi	Ke ʻano kumu rosuvastatin	Hoʻololi AUC rosuvastatin
Cy-200orin 75-200 mg 2 mau lā i kahi lā, 6 mahina.	10 mg 1 manawa i kēlā me kēia lā., 10 lā	ʻO ka hoʻonui 7.1x
Atazanavir 300 mg / ritonavir 100 mg 1 manawa i kēlā lā., 8 lā	10 mg ʻaʻai pākahi	Hoʻonui 3.1x
Simeprevir 152 mg 1 manawa i kēlā lā., 7 lā	10 mg ʻaʻai pākahi	2.8x hoʻonui
Lopinavir 400 mg / ritonavir 100 mg 2 mau lā i ka lā., 17 mau lā	20 mg 1 manawa i kēlā lā	E hoʻonui i nā manawa 2.1
Clopidogrel 300 mg (kala ʻia) a laila 75 mg ma hope o 24 mau hola	20 mg ka pona hoʻokahi	ʻO ka hoʻonui a 2x
Gemfibrozil 600 mg 2 mau lā i kahi lā, 7 lā	80 mg ʻaʻano pā	1.9x hoʻonui
Eltrombopag 75 mg 1 kahi lā lā. 10 lā	10 mg ʻaʻai pākahi	Hoʻonui ka 1.6x
Darunavir 600 mg / ritonavir 100 mg 2 mau lā i kahi lā, 7 lā	10 mg 1 manawa i kēlā lā	Hoʻonui ka manawa 1,5
Tipranavir 500 mg / ritonavir 200 mg 2 mau lā i ka lā., 11 lā	10 mg ʻaʻai pākahi	ʻOi ka manawa o 1.4
Dronedarop 400 mg 2 mau lā i kahi lā.	ʻAʻohe ʻikepili	ʻOi ka manawa o 1.4
Itraconazole 200 mg 1 manawa i kēlā lā., 5 lā	10 mg a i ole 80 mg i hoʻokahi	ʻOi ka manawa o 1.4
Ezetimibe 10 mg 1 manawa i kēlā lā., 14 lā	10 mg hoʻokahi manawa i ka lā, 14 lā	1.2 ka piʻi ʻana
Kauhauwe 700 mg / ritonavir 100 mg 2 mau lā i kahi lā, 8 mau lā	10 mg ʻaʻai pākahi	ʻAʻole kahi hoʻololi
Aleglitazar 0.3 mg. 7 lā	40 mg, 7 lā	ʻAʻole kahi hoʻololi
Silymarin 140 mg 3 mau lā i ka lā. 5 lā	10 mg ʻaʻai pākahi	ʻAʻole kahi hoʻololi
Fenofibrate 67 mg 3 mau lā i kahi lā, 7 lā	10 mg, 7 lā	ʻAʻole kahi hoʻololi
Rifampin 450 mg I ka lā hoʻokahi. 7 lā	20 mg ka pona hoʻokahi	ʻAʻole kahi hoʻololi
Ketoconazole 200 mg 2 mau lā i kahi lā, 7 lā	80 mg ʻaʻano pā	ʻAʻole kahi hoʻololi
Fluconazole 200 mg 1 manawa i kēlā lā., 11 lā	80 mg ʻaʻano pā	ʻAʻole kahi hoʻololi
Erythromycin 500 mg 4 wā i ka lā., 7 lā	80 mg ʻaʻano pā	28% hōʻemi
Baikalin 50 mg 3 mau lā i kahi lā, 14 lā	20 mg ka pona hoʻokahi	ʻO 47% hōʻemi

ʻO ka hopena o ka rosuvastatin ma luna o nā lāʻau lapaʻau
Nā Huaʻōlelo K ka hoʻomaka ʻana o ka lāʻau rosuvastatin a i ʻole ka hoʻonui ʻana i ka maʻa i loko o nā mea maʻi e loaʻa like me ka vitamin K antagonist (e.g. warfarin) e alakaʻi i ka hoʻonui ʻana i ka International Normalized Relation (MHO). ʻO ka hoʻoneʻe ʻana o rosuvastatin a i kahi hōʻemi ʻana i ka nui o ka lāʻau lapaʻau hiki ke alakaʻi i ka hoʻoilo ʻana i ka MHO. I kēlā mau kūlana, ua kauoha ʻia ka mana o ka MHO.
Oral contraceptives / hana hoʻohalike maʻi hormon: ka manawa like o ka rosuvastatin a me nā kūmole waha e hoʻonui i ka AUC o ka ethinyl estradiol a me ka AUC o norgestrel e 26% a 34%, kekahi. Pono e hoʻonui ʻia i ka neʻe ʻana o ka plasma i ka wā e koho ai i ka nui o ke kūpeʻe waha.
ʻO ka ʻikepili Pharmacokinetic ma ka hoʻohana pinepine ʻana i ka lāʻau Krestor ® a me ke ʻano hoʻonaninani hormone neʻe ʻole, no laila, ʻaʻole hiki ke haʻalele ʻia kahi hopena like me ka hoʻohana ʻana o kēia hui. Akā, ua hoʻohana nui ʻia kēia hui i ka wā o nā hoʻokolohua lapaʻau a ua hoʻomanawanui maikaʻi ʻia e nā mea maʻi.
ʻO nā lāʻau lapaʻau ʻē aʻe: ʻaʻohe ʻano hui like ʻole o ka rosuvastatin me ka digoxin.

Nā ʻōlelo kikoʻī

Nā hopena hopena
I ka poʻe maʻi i loaʻa nā wai kiʻekiʻe o Krestor ® (ʻoi aku ka 40 mg), ua nānā ʻia ka proteinuria tubular, i ka nui o nā maʻi he transient. ʻAʻole hōʻike ʻia ʻo proteinuria i ka maʻi aʻokiʻoki a me ka hoʻomau ʻana o ka maʻi ʻōiwi. I ka poʻe maʻi e lawe ana i ka lāʻau lapaʻau ma kahi maʻa o 40 mg, ʻoi ʻia ia e nānā i nā mākau hana o ka renal i ka wā mālama.
Mai ka ʻōnaehana musculoskeletal
Ke hoʻohana nei i ka lāʻau lapaʻau Krestor ® i loko o nā āpau āpau, a keu hoʻi ka wā e lawe ai i ka nui o nā lāʻau i ʻoi aku o 20 mg, ua hōʻike ʻia nā hopena e pili ana i ka ʻōnaehana musculoskeletal: myalgia, myopathy, i nā hihia lohi, rhabdomyolysis.
ʻO ka hoʻoholoʻana o ka phosphokinase creatine
ʻAʻole pono ke hoʻokau i ka manaʻo ʻo CPK ma hope o ka hoʻoikaika kino a i ʻole he mau kumu ʻē aʻe paha e hoʻonui ai i ka CPK, hiki iā ia ke alakaʻi i kahi wehewehe pololei o nā hopena. Inā hoʻonui hoʻonui ʻia ka pae mua o ka CPK (5 mau manawa i ʻoi aku ma mua o ka palena o ka maʻamau), pono e hana ʻia kahi helu ʻana ma hope o nā lā 5-7. ʻAʻole hoʻomaka nā lāʻau e hoʻokau inā hōʻoia ka hoʻāʻo hou ʻana i ka pae mua o ka CK (ʻoi aku ma mua o 5 mau manawa i ʻoi aku i ko ka palena palena o maʻamau).
Ma mua o ka hoʻomaka ʻana i kahi lapaʻau
Ke kuhikuhi ʻana iā Krestor ®, a me ka mea i ke kuhikuhi ʻana i nā mea ʻē aʻe o ka HMG-CoA reductase, pono e mālama ʻia i ka poʻe maʻi me nā mea e pili ana i ka maʻi myopathy / rhabdomyolysis (e ʻike i ka ʻāpana "Kaʻihele") pono, ka nānā ʻana o nā maʻi.
I ka wā mālama
Hoʻomaopopo i ka mea maʻi e pili ana i ka pono e hōʻike koke i ke kauka e pili ana i nā hihia o ka hoʻomaka koke ʻana o ka ʻeha o ka naʻau, nā ʻōpū palupalu a i ʻole ka hoʻopili ʻana, ka mea pū me ka malaise a me ka ʻala. I kēlā mau maʻi maʻi, pono e hoʻoholo ʻia ka pae o ka CPK. Pono e hoʻokuʻu ʻia ka therapy inā hoʻonui ʻia ke kiʻekiʻe o ka CPK (ʻoi aku ma mua o 5 mau manawa e hoʻohālikelike ʻia me ke palena palena o ka maʻamau) a inā i ʻōlelo ʻia nā hōʻailona o nā ʻūlū a hana i nā pilikia o kēlā me kēia lā (ʻoiai inā he 5 mau makahiki ka pae o ka CPK ma mua o ka luna palena o ke ʻano) Inā lilo nā hōʻailona a hoʻi hou ka pae CPK, pono e noʻonoʻo e hāʻawi hou i ka lāʻau Krestor ® a i ʻole HMG-CoA reductase inhibitors i nā haʻahaʻa haʻahaʻa me ka kiaʻi pono ʻana o ka mea maʻi.
ʻO ke kāohi pono ʻana i ka CPK i ka haʻalele ʻana i nā hōʻailona kūpono ʻole.
ʻO nā hihia kaʻoi loa o ka pale ʻana i ka myopathy paʻa-mediated me nā hōʻike hōʻike i ke ʻano o ka nāwaliwali mau o nā musx proximal a me ka hoʻonui ʻana i ke kiʻekiʻe o ka CPK i ka serum koko i ka wā e mālama ai a i ka wā e lawe ai i nā statins, me ka rosuvastatin, i ʻike ʻia. Pono nā haʻawina hou o ka ʻiʻo a me ka hoʻonaninani, nā noi ʻana serological, a me ke ʻano immunosuppressive paha e pono ai.
ʻAʻohe hōʻailona i hoʻonui ʻia i ka hopena ma ke ʻili o ka iwi i ka wā e lawe ai iā Krestor ® a me ka hopena concomitant. Eia naʻe, kahi piʻi i ka ulu ʻana o myositis a me myopathy i nā poʻe maʻi e lawe ana i nā inhibitors ʻē aʻe, ua hōʻike ʻia ka HMG-CoA reductase i hui pū ʻia me nā derivatives acid fibric, e pili ana i ka gemfibrozil, cyclosporin, ka waikui nikotinik, nā mea āpau azole antolungal, nā protease inhibitor a me nā antibiotika macrolide. Hoʻonui ka Gemfibrozil i ka hopena o ka myopathy i ka hui pū ʻana me kekahi mau HMG-CoA reductase inhibitors. No laila, ʻaʻole i ʻōlelo ʻia ʻo ka lawelawe like ʻana o ka lāʻau Krestor ® a me gemfibrozil. Pono ke ʻano o ka hopena i ka pōmaikaʻi e kau pono ai ka wā e hoʻohana ai i ka mākaukau ʻo Crestor ® me ka fibrates a i ʻole nā lipid-hoʻohiolo ʻana i nā kūmole ʻo nikotinic. ʻO ka hoʻohana ʻana i ka lāʻau Krestor ® ma kahi kikoʻī o 40 mg me nā fibrates ua contraindicated. (ʻike i nā ʻāpana "Hoʻopili ʻana i nā lāʻau lapaʻau a me nā ʻano like ʻole o ka hopena o ka lāʻau", "Contraindications").
2-4 mau pule ma hope o ka hoʻomaka ʻana o ka hoʻōla a me / a me ke hoʻonui ʻana o ka maʻa o ka mākaukau ʻo Krestor ®, ka nānā ʻana o ka hoʻoulu ʻana o lipid (pono ke hoʻoponopono ʻia inā pono paha).
Pāʻālua
Hoʻomaopopo ʻia e koho i nā hōʻailona o ka ate ma mua o ka hoʻomaka ʻana o ka lāʻau a me 3 mau mahina ma hope o ka hoʻomaka ʻana o ka hoʻomaʻamaʻa. Pono e hoʻohana ʻia ka hoʻohana ʻana i ka lāʻau Krestor ® i ʻole e hoʻemi ʻia ka hopena o ka lāʻau inā inā hoʻemi ʻia ka nui o ka hana transaminase i ka serum koko, he 3 mau manawa kiʻekiʻe ma mua o ka palena o luna.
I ka poʻe maʻi me ka hypercholesterolemia ma muli o ka hypothyroidism a me ke nephrotic syndrome, e pono e mālama ʻia i ka mālama ʻana o nā maʻi lalo ma mua o ka mālama ʻana me ka lāʻau Crestor ®.
Nā iwi kūikawā. Nā hui ʻano
I ka wā o nā haʻawina ʻo pharmacokinetic ma waena o nā mea maʻi Kina a me Kepani, ua ʻike nui ʻia ka nui o ka neʻe ʻana o ka rosuvastatin i hoʻohālikelike ʻia me nā mea ʻike i loaʻa i waena o nā mea maʻi o ʻEulopa (e ʻike i nā ʻāpana "Dosage and Administration" a me "Pharmacokinetics").
Nā mea hoʻomaloka piha
ʻAʻole hoʻohana ʻia ka hoʻohana pū ʻana o ka lāʻau me nā inhibitor ʻo protease (e nānā i ka ʻāpana "Hoʻohālikelike me nā lāʻau ʻē aʻe a me nā ʻano like ʻole".
Lactose
ʻAʻole pono e hoʻohana ʻia ka lāʻau lapaʻau i nā mea maʻi me ka nele o ka lactase, intolerance galactose a me ka malabsorption glucose-galactose.
ʻO ka maʻi māmā interstitial
Ke hoʻohana nei i kekahi mau statins, no ka wā lōʻihi loa, ua hōʻike ʻia nā hihia huna o ka maʻi interstitial lung. Hiki i nā hoʻohālikelike o ka maʻi ke komo i ka pōkole o ka hanu, ka umauma hoʻi ʻole, a me ke ʻano o ka nui (nāwaliwali, ke kaupaona ʻana o ke kaupaona ʻana, a me ka ʻeha). Inā kānalua ka maʻi lemela interstitial, pono e hoʻokuʻu ʻia ka lāʻau statin.
ʻAno maʻi type 2
I ka poʻe maʻi me ka kaʻe o ka glucose o 5.6 a 6.9 mmol / L, ua pili nā lāʻau Crestor ® me ka nui o ka loaʻa ʻana o ka maʻi diabetes type 2.

Hoʻomaopopo i ka hiki ke lawe i kahi kaʻa a me nā mīkini ʻē aʻe

ʻAʻole i aʻo ʻia nā haʻawina e noiʻi i ka hopena o ka hoʻomākaukau o Krestor ® ma ka hiki ke pana i kahi kaʻa a hoʻohana i nā mīkini. Eia nō naʻe, ma muli o nā waiwai pharmacodynamic, ʻaʻole pono o Krestor ® i kēlā hopena. Pono e mālama pono i ka wā e alakaʻi ana i ke kaʻa a i ʻole ka hana e pili ana i ka piʻi ʻana o ka nānā ʻana a me ka noʻonoʻo psychomotor (maʻi hōʻeha i ka wā o ka therapy).

Ma muli o ke kolamu nui, ua kuhikuhi ke kauka iā Krestor ma ka 5 mua

Ma muli o ke kolamu nui, ua kuhikuhi ke kauka iā Krestor ma ka 5 mg nui, a laila hoʻonui i ka maʻi i 10 mg. Ua lilo ka maikaʻi o ka hoʻomaikaʻi. No 3 mau makahiki, hōʻike ʻia nā hōʻike hana maʻa maʻamau e hoʻoponopono ʻia nā mea āpau. Alaila, ku mai ke ano o ke ano, i hoailonaia e ka mai, ke eha o ka io, ka eha, ka urine poepoe, ke ku e hiamoe ana, a me ka hoohaahaa. Ua hoʻouna ke kauka i kahi hoʻokolohua holoʻokoʻa - nā ho'āʻo koko, x-hihi, nā ultrasounds a me ka tomography compute. Ua maopopo ke kumu ʻaʻole i pili i ke anuanu maʻamau a i ʻole ka lolo. Ua hōʻike ʻia nā pilikia me ka puʻuwai. Ua hooki koke wau i ka lawe ʻana iā Crestor.

Ua hoʻohaʻahaʻa ke keʻa i kaʻu kolamu a me nā triglycerides. Akā ʻike wau i ka hoʻonui

Ua hoʻohaʻahaʻa ke keʻa i kaʻu kolamu a me nā triglycerides. Akā ʻike wau kahi mahuahua o ke kaumaha, luhi, ke emi o ka nui. Aia ka ʻōpū, ka ʻeha ma nā lima, ka ʻeha ma ka ʻāʻī. Hana ka cardiologist i kahi hoʻokolokolo a ʻaʻole hoʻoholo i ke kumu o kēia mau ʻōuli. Ua ho'ōki wau i ka inu ʻana o Krestor, a i loko o 2 a 3 paha mau pule ua hoʻihoʻi ʻia koʻu kaumaha a me ka hoʻihoʻi maikaʻi. Hoʻonui wau i kaʻu ʻai ʻaʻa iʻa, a hoʻomaka e mālama nui i ka meaʻai. Ke manaʻo nei wau ʻaʻole ʻoe e hoʻi e lawe i statins.

Ua lawe au iā Krestor 10 mg ma mua o 10 mau makahiki. He hana maikaʻi loa kāna.

Ua lawe au iā Krestor 10 mg ma mua o 10 mau makahiki. He hana maikaʻi loa kāna, ua hōʻemi i kaʻu kolamu i ka maʻamau. Akā, no nā makahiki he nui koʻu maʻi i ka ʻeha ʻana, a ʻaʻole hiki i nā kauka ke wehewehe. ʻO kekahi mea e pili ana i ka hoa aloha o ka moʻolelo a hiki i koʻu ʻehaʻeha ke hopena i ka hana a Krestor. E nānā i kona ʻōhumu ʻana, ua hooki au i ka inu ʻana i ka lāʻau. A ʻo kaʻoiaʻiʻo, ma hope o kekahi mau mahina i hoʻopau ʻia ai ka ʻeha pū ʻana. ʻĀnō, ʻaʻole au e ʻae hou iā Krestor.

Inu wau i ka 2,5 mg o Crestor i kēlā me kēia lā (ʻo ia ka hapalua he 5 mg tablet). Ua iho i lalo

Inu wau i ka 2,5 mg o Crestor i kēlā me kēia lā (ʻo ia ka hapalua he 5 mg tablet). ʻO kēia i hoʻohaʻahaʻa loa i kaʻu kolamu mai 248 a 193. ʻAʻole maikaʻi, akā maikaʻi ka lāʻau lapaʻau. Hoʻomaka wau i ka inu me ka 10 mg i kēlā me kēia lā, akā loaʻa ka peluhupulu o nā māla a me ka piʻi ʻana o nā pēpē o nā pēpēUa haʻi mai ke kauka iaʻu e hoʻāʻo i nā statins ʻē aʻe, akā like ka hopena like lākou. No laila, hoʻohaʻahaʻa mākou i ka nui o Crestor a hiki i ka hopena o nā ʻaoʻao. Hana maikaʻi loa ia a ʻaʻole i ʻike ʻia nā hopena koʻikoʻi.

Ma kahi o kahi maʻi maʻi maʻi, loaʻa nō hoʻi iaʻu ka cholesterol kiʻekiʻe

I ka hoʻohuiʻana i kahi maʻi maʻi maʻi, ua loaʻa hoʻi iaʻu i ka cholesterol kiʻekiʻe (e ʻike ʻia i ka 12 mau makahiki i hala). Aia wau i ka mea ʻai kaupalena, a ʻai mau i ka hua a me ka ʻiʻo. Akā naʻe, ua kiʻekiʻe kaʻu kolamu. ʻAʻole au makemake i lawe i nā statins, no ka mea, ua loaʻa iaʻu kahi pākēna i ka wā i hele ai au i kahi lipitor. Akā i ke kauwela i hala, ua lilo nui nā hōʻailona i ka nui o ka Krestor e inu. Eia nō naʻe, ua hoʻomaka wau me 5 mg mau manawa i ka hebedoma. I kēia manawa, 8 mau mahina ma hope, he BOW ko kaʻu kolamu a ʻo nā mea hōʻailona ʻē aʻe i loko o kahi ākea maikaʻi. Ua ʻoluʻolu loa koʻu poʻe endocrinologist a ʻaʻohe ʻōlelo he kumu no ka hoʻonui ʻana i ka lāʻau i ka 10 mg. ʻOiaʻiʻo, kekahi manawa ke ʻeha ʻia wau i kekahi ʻeha ma nā kuʻekuʻe ma ka lima a me nā ʻīlio, akā hiki mai kēia.

Ka hoʻonohonoho ʻana a me ke ʻano o ka hoʻokuʻu ʻana

ʻO ka waiwai ikaika o Krestor ʻo rosuvastatin. Ka pūloli ʻana o ka lāʻau lapaʻau pū kekahi pū me nā mea kōkua: lactose, cellulose, magnesium stearate, calcium phosphate, a me nā mea ʻē aʻe. Loaʻa Crestor i ke ʻano o nā papa ʻulaʻula, kahi ʻano pōʻai i manaʻo ʻia no ka hoʻoponopono waha. Wahi a ke manual radar, ʻae like ke ʻano o ka Latin latike: Rp .: Rosuvastatini 0.01 D.t.d.N.10 i tab.obd. S. 1–1.

Loaʻa ka lāʻau lapaʻau i kekahi mau hewa.

Kahu 5 mg
Koko 10 mg
Kahu 20 mg
Kapaha 40 mg.

Wahi a ka pākuʻi, aia ke kahakaha ma kekahi ʻaoʻao o ka papa. No kekahi laʻana, ma kahi maʻi o 10 mg, ʻōlelo ia "ZD4522 10" ma luna o ia. Hoʻokomo ʻia nā papa i loko o kahi pūʻulu blister o 7 mau ʻāpana. I hoʻokahi pahu pahu mea hiki ke lilo i 1, 4, 14 mau kuʻi.

I nā manawa pinepine, ua kūʻai ʻia kekahi maʻa o nā 10 mg - 98 papa, ʻo ia hoʻi, he 14 mau blisters i ka pālahalaha. Hāʻawi ʻia i ke kūʻiʻo i nā statins no ka hoʻohana ʻana i ka wā lōʻihi, ʻike ka poʻe he nui i ka pono e kūʻai i nā paʻi nui i ka manawa hoʻokahi.

ʻO ke kumu o ka hana

ʻO ke kea kahi mea lawelawe lipid-hoʻohaʻahaʻa, ʻo ia hoʻi, ʻo lipid-hoʻohaʻahaʻa. ʻO kāna hopena koʻikoʻi ka mea e hoʻemi i ka nui o nā lipoproteins o nā ʻano ʻē aʻe i ke kino. Penetrating i ka palu - ke kino e pili ana i ka hana o ka kolamu, rosuvastatin, ka mea ikaika o ka lāʻau lapaʻau, he hopena pale i ka hana ʻana o kekahi huina.

Eia naʻe, komo ke kolamu i ke kahe a ka hopena ma kahi o nā nalo. ʻO ka ʻāpana o kēia mau mea e komo i ke kino me nā meaʻai, ʻoi aku ka momona, nā meaʻai junk. E kōkua ka hana a ka lāʻau lapaʻau e hoʻomaʻemaʻe i nā kīʻaha koko o nā lipoproteins haʻahaʻa haʻahaʻa i hōʻiliʻili ʻia. Ua kapa ʻia kēia kūlana ka mua o ka atherosclerosis.

Inā hoʻomaka mua ka atherosclerosis e hoʻomohala, ua pā ʻia nā kīʻaha koko a me nā kīpē i nā waiho kolole a i nā ʻalā paha, he hopena maikaʻi ʻo Krestor ma luna o lākou. Komo ia i loko o nā moku, hoʻomaʻemaʻe iā lākou i nā waihona. Ma muli o kēia, ua māhuahua ka lumen i loko o nā moku a me nā ʻāpana, e holo pono ka kahe o ke kahe ma nā wahi i ʻāpono ʻia.

ʻO kekahi o nā hoʻopiʻi o ka plaher atclosclerotic plomb he thrombosis, ka mea e hoʻoweliweli i ka haki ʻana o kahi moku a i ʻole ka mea ʻae. Hōʻalo nā statins i kēia ma ka hoʻonui ʻana i ka hoʻomaʻemaʻe ʻana iā lākou ma ka hoʻemi ʻana i ka nui o nā pākau.

No Krestor no nā kenekini ʻehā o ka makahiki, ua manaʻo ʻia kēia hui e ʻoi loa ka maikaʻi. Ma waho aʻe o ka mea e kōkua nui ana kāna hoʻomākaukau e hōʻemi i ka nui o ka "kino" kolamu i ke koko, hoʻonui lākou i ka hana o ka "maikaʻi". ʻO "cholesterol" maikaʻi he mea pono ia no ka hana maʻamau o nā kino kūloko, ka hana ʻana o nā hormones, ka ikaika o nā membranes a me nā kaʻina hana ʻē aʻe.

Nā ʻōkuhi no ka hoʻohana

Kahi nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana i ka lāʻau lapaʻau i loko o kēlā me kēia pakuhi, he mea nui ia no nā poʻe maʻi e familiari iā lākou iho ma mua o ka lawe ʻana i nā paila. Hoʻolaha ʻia ka dosage a me ke ʻano o ka hoʻokele ʻana e ka neʻe ʻana o ka mea kauā. Hoʻomaʻamaʻa ʻia ka manawa manuahi, ʻo ka mea nui ka lawe i ka lāʻau lapaʻau i kēlā me kēia lā i ka manawa like.

Wahi a ka poʻe loea, ʻo ka manawa ahiahi ka mea kūpono loa no ka lawe ʻana i nā statins, ʻoiai ma ka hopena o ka lā e nui ka nui o ka kolamu ma mua o ke kakahiaka.

Hoʻohana ʻia ka huahana no ka hoʻokele waha, holoi ʻia me ka wai liʻiliʻi. ʻAʻole pono ʻoe e hoʻopili i ka papa. Ma mua o ka hoʻoholo ʻana i ka dosage, ua kuhikuhi ʻia ka mea maʻi i kahi maʻi holoʻokoʻa e nānā i ke ʻano o nā moku, helu ʻai, a me nā kino o ka ʻōnaehana cardiovascular.

ʻO ka maʻamau maʻamau ʻo ka 10 mg ma mua. I hoʻokahi mahina ma hope o ka hoʻomaka ʻana o ka hoʻōla, pono ka mea maʻi e mālama i ke ʻano koko, a inā he pono ka lāʻau lapaʻau, ʻaʻohe ʻina nā hopena ʻaoʻao, hiki ke hoʻonui ʻia ka dosage i 20-40 mg i kēlā me kēia lā. A laila, i ka wā o ka wā mālama holoʻokoʻa, pono ia e hana pinepine i kahi loiloi e loiloi i ka hopena a hoʻoponopono i ka dosis.

Inā hoʻoholo ʻia ka lāʻau lapaʻau no ka pale ʻana o nā maʻi o ka ʻōnaehana cardiovascular, ʻo ka nui ma mua o ka nui o ka 5 mg. ʻO ke lōʻihi o ka manawa, e like me ka mea i hōʻike ʻia e ke kauka hele, hiki ke hoʻonui ʻia pū.

ʻO ka maʻamau, kuhikuhi nā statins i ke ola, inā ʻaʻole, a laila ʻo ka lōʻihi o kā lākou kiʻi i ka liʻiliʻi he 3-4 mau mahina. ʻAʻole hiki iā ʻoe ke hoʻokaʻawale i ka lawe ʻana i nā panila wikiwiki, ke kauka nei ke kauka hele i kahi hana e like me ka hoʻemi ʻana o ka laila i kēlā me kēia lā, a laila hiki wale ke mālama ʻia.

Nā Hoʻohui

ʻO kekahi lāʻau lapaʻau i ka pūʻulu statin he nui o nā contraindications no ke hoʻohana ʻana, no ka mea ua manaʻo ʻia he mau hana. ʻAʻole hiki ke hoʻohana ʻia ke keʻa no kēia mau hōʻailona:

makahiki i 18 makahiki
hapai a me ka umauma,
ka poʻe kūloko ʻole ia e rosuvastatin a i ʻole kekahi mea ʻē aʻe i hoʻohui ʻia ma ka ʻano,
maʻi ʻōiwi luhi i ka wā o ka exacerbation,
myopathy.

No ka poʻe maʻi i pilikia o ka hoʻomohala ʻana i ka myopathy, ʻo kahi maʻi o 40 mg i kēlā me kēia lā he contraindicated. Kēia mau a kuhikuhi ʻia iā Crestor 20 mg a i ka 10 mg mua.

A hoʻohana pū ʻia ka lāʻau lapaʻau ma nā poʻe maʻi e lawe nui ana i ka waiʻona. No ka mea nui ka hana o nā statins i ka nui o ke kō, inā e loaʻa ka mea i pau o nā mea inu ʻona, ʻaʻole ia e kū i kēlā ʻano koi. Inā hoʻomaka ka mea maʻi i ka waiʻona e inu i ka inu ʻana, hele i kahi papa o ka hou a me ka hoʻihoʻi, hiki ke kuhikuhi ʻia ka lāʻau lapaʻau, akā hoʻomaka me nā hopena liʻiliʻi.

Nā hopena hopena

Ma waena o nā mea maʻi e lawe ana iā Krestor, hōʻemi pinepine ʻia nā hopena i ka poʻe i hahai ʻole i nā ʻōlelo aʻo a ke kauka, ʻoi aku i ka nui o ka dosage a i ʻole nāʻehewa ʻana i nā lula o nā contraindications. ʻO nā hopena ʻaoʻao ʻokoʻa paha:

ʻeha nā maʻi hoʻi, ʻeha o ka ʻōpū,
hōʻea, hōʻeha,
hoʻohui hoʻonohonoho paʻa
ʻili ʻia ka ʻili, ʻili,
myalgia
ʻaiaiaia
ke hiʻohiʻona o nā puʻuwai.

He aha ka mea maikaʻi ʻo Krestor a i ʻole Rosuvastatin

ʻO ke kumukūʻai kumukūʻai o rosuvastatin 20 mg 28 pcs. a ma kahi o 550 rubles, aʻo ka uku o ka Crestor he aneane ʻeono manawa e hala. No kēia kumu, nui nā maʻi maʻi e koho i kahi koho ʻoi aku ka uku. He aha ka ʻokoʻa ma waena o nā lāʻau lapaʻau, koe wale nō inā he ʻano ʻē aʻe i ke kumukūʻai?

No krestor no nā statins o ka hanauna ʻehā hope loa, a ʻo ia ka mea nui o ka lāʻau. He kūpono, palekana pono. Wahi a nā kauka he nui, inā ʻoe e hoʻomaka i ka lawe i statins, a e lōʻihi ana ka manawa, hiki paha ke ola, no laila, ʻo kēia ke ʻano kiʻekiʻe o ka ʻāina. ʻO kēia lāʻau lapaʻau ʻo Krestor ia.

Loaʻa nā pōmaikaʻi o Crestor, ka mea, e like me kona mau generics a me nā substitutes e hōʻoiaʻiʻo ʻia, i komo pū ʻia: