Ua hoʻopuka nā kauka mai Kaleponi a me Boston i nā peni insulin mua o ka honua - kōkua lākou i ka hāʻawi ʻana i nā mea ikaika i ka ʻōnaehana hoʻoponopono kanaka, pale aku i ka lāʻau lapaʻau mai nā hopena o ka ʻōkuhi. Kahi ʻia ka wehewehe ʻana o nā papa i ka nūpepa PNAS.

I kēia lā, 340 miliona mau kānaka me ka maʻi maʻi e noho nei ma ka honua. ʻO ka hapa nui o lākou e kūkulu i nā inikini o ʻeono i kēlā me kēia lā e hoʻopaʻa i ke ʻano o ke koko i loko o ke kino. Ma muli o nā pōʻino o ka insulin, he hanana ka nui o ka lāʻau lapaʻau i ka ʻole, akā i ka wā o ke keʻa ʻana i kekahi ʻano inoa o ka lāʻau lapaʻau. I kēia mau makahiki he 10 i hala iho nei, ua hoʻāʻo hou nā kauka e hoʻomohala i kahi analogue palekana i ka insulin me kahi ʻōmole like like, a i ʻole he ala hou e kau ai i ka hormone i loko o ke kino.

Kuhi o ka papa lāʻau o ka insulin i ka hui pū ʻana o kekahi mau māmona ʻaʻole wai i loaʻa i ka wai, akā ke ʻano e like me ka wai ma muli o ke ʻano haʻalulu haʻahaʻa, pale i ka waiwai ikaika mai ka ʻōpū o ka ʻōpū. Inā ma loko o ka ʻōpū i ka membrane o ka papa ka pale i ka insulin mai ka wai, a laila i loko o nā ʻōpū o ka alkalis e hūʻī, a hoʻoneʻe i nā hormones insulin.

Eia kekahi, hoʻoneʻe ka wai ionic i nā molekole insulin e komo i loko o ka paia o ka ʻōpū a me ke koko, e hoʻokū iā lākou, e ʻae ana i nā papa no nā hana he 12 mau hola. ʻOi ʻia aia e kū ʻia nā papa i ka mākeke i loko o kekahi mau makahiki, ma hope o ka pau ʻana o nā hoʻokolohua maʻi.

Ua hoʻopuka nā kauka mai Kaleponi a me Boston i nā peni insulin mua o ka honua - kōkua lākou i ka hāʻawi ʻana i nā mea ikaika i ka ʻōnaehana hoʻoponopono kanaka, pale aku i ka lāʻau lapaʻau mai nā hopena o ka ʻōkuhi. Kahi ʻia ka wehewehe ʻana o nā papa i ka nūpepa PNAS.

I kēia lā, 340 miliona mau kānaka me ka maʻi maʻi e noho nei ma ka honua. ʻO ka hapa nui o lākou e kūkulu i nā inikini o ʻeono i kēlā me kēia lā e hoʻopaʻa i ke ʻano o ke koko i loko o ke kino. Ma muli o nā pōʻino o ka insulin, he hanana ka nui o ka lāʻau lapaʻau i ka ʻole, akā i ka wā o ke keʻa ʻana i kekahi ʻano inoa o ka lāʻau lapaʻau. I kēia mau makahiki he 10 i hala iho nei, ua hoʻāʻo hou nā kauka e hoʻomohala i kahi analogue palekana i ka insulin me kahi ʻōmole like like, a i ʻole he ala hou e kau ai i ka hormone i loko o ke kino.

Kuhi o ka papa lāʻau o ka insulin i ka hui pū ʻana o kekahi mau māmona ʻaʻole wai i loaʻa i ka wai, akā ke ʻano e like me ka wai ma muli o ke ʻano haʻalulu haʻahaʻa, pale i ka waiwai ikaika mai ka ʻōpū o ka ʻōpū. Inā ma loko o ka ʻōpū i ka membrane o ka papa ka pale i ka insulin mai ka wai, a laila i loko o nā ʻōpū o ka alkalis e hūʻī, a hoʻoneʻe i nā hormones insulin.

Eia kekahi, hoʻoneʻe ka wai ionic i nā molekole insulin e komo i loko o ka paia o ka ʻōpū a me ke koko, e hoʻokū iā lākou, e ʻae ana i nā papa no nā hana he 12 mau hola. ʻOi ʻia aia e kū ʻia nā papa i ka mākeke i loko o kekahi mau makahiki, ma hope o ka pau ʻana o nā hoʻokolohua maʻi.

Wahi a nā helu helu WHO, i kēia lā ma ke ao nei he 340 miliona mau kānaka e maʻi ana i ka maʻi diabetes

Kālina ka hapanui o lākou e lawe i ʻelua a i ʻole hoʻi i ka 5-6 mau inikini o ka inikini i kēlā me kēia lā e hiki ai ke hoʻopaʻa i ke kō koko. ʻO ka insulin he lāʻau weliweli a me kona overdose ma muli o ka nūhou i kahi brand hou o ka lāʻau hiki ke hōʻeha i ka olakino a he make paha ma ke ʻano o ka hypolycemia - he hōʻemi maikaʻi loa i ka puna koko.

I kēia mau makahiki i hala, ua hoʻoikaika ikaika nā kānaka ʻepekema i ka hana ʻana i ke aniani o ka insulin, kahi mea like kū like me nā ʻōnaehana like ʻole, a i ʻole nā ​​ʻōnaehana like no ka hoʻolauna ʻana i ka hormone i loko o ke kino e pale ai iā ia mai ka overdose.

No ka laʻana, i ka makahiki 2013, ua hana ʻo ʻAmelika ʻAmelika i kahi micro-dropper kūikawā "jellyfish" i hiki ke hoʻopaʻa ʻia ma lalo o ka ʻili, kahi e hoʻokuʻu lohi ai i ka insulin i nā lā he nui.

ʻO nā kauka a me nā mea maʻi iā lākou iho, e like me ka leka Mitragotri, ua moemoe nui ka loaʻa o ka insulin e like me nā aspirin a i nā papa ʻē aʻe.

Aia a hiki i kēia wā, ʻaʻole hiki ʻole kēia, ʻo ka mea momona a me nā enzyme e hoʻokaʻawale i nā meaʻai protein e hoʻoneʻe i nā molekule ma mua o ko lākou komo ʻana i ka pā o ka ʻōpū.

Ua kālele ʻo nā ʻepekema mai Harvard a me ke Kulanui o Kaleponi ma Santa Barbara i kēia pilikia me ʻelua mau mea - he pale i kū i ka hana o ka ʻōpū o ka ʻōpū, a me nā mea kūikawā e kāhea ana ka poʻe kemika "wai ionic."

Ma kēia huaʻōlelo, ʻike ka poʻe ʻepekema i kahi kāwili o kekahi mau paʻakai, ʻaʻohe wai o ka molekui wai hoʻokahi, akā i ka manawa like ia ʻano ʻano wai me ka wai hoʻohaʻahaʻa ʻia. ʻO lākou, e like me ka ʻōlelo ʻana a nā kānaka ʻepekema i hiki ke hoʻohana ʻia e like me ke ʻano o ka "wai" hoʻāla no ka insulin, ka mea e pale ai iā ia i nā enzymes i ka wā o ka neʻe ʻana i loko o nā ʻōpū.

ʻO ka mea huna o kāna hana, e like me ka wehewehe ʻana o Mitragotri, he hana ʻē kona i nā ʻano me nā pae pH ʻokoʻa.

I loko o ka ʻōpū "acidic", noho mau ia a pale i kona wai ʻana i ka komo ʻana i loko, a i loko o ka ʻatikala "alkaline", hoʻoneʻe ka wai o ka ionic a hoʻokuʻu i nā molekamu.

Eia kekahi, e like me ka hōʻike ʻana o ka wai i ka iole, e kōkua ana i ka molekole insulin e komo i loko o kahi paʻa ma waena o nā pā o ka ʻōpū a me ke kahe, a hoʻonā i nā molekone o ka hormone, e ʻae ana i nā papa ma kona papa e pili ana i ka mau hola 12 a mālama ʻia no nā hola ʻelua i loko o kahi keʻena lāʻau lapaʻau a hiki i ka wa lumi.

E like me ka manaʻo o Mitragotri a me kāna mau hoa hana, e hele ana kā lākou mau papa i nā maʻi āpau o nā hoʻokolohua lapaʻau a me nā hoʻokolohua holoholona i nā manawa pōkole loa, a e ʻike ʻia i loko o nā lāʻau lapaʻau i nā makahiki e hiki mai ana.

Hāʻawi ka manaolana nui o kēia i ka neʻe ʻana o nā mea ʻelua o ka waiona ionic - ʻākae B4 a me ka waikawa geranium - ua hoʻohana ʻia ʻo ia no nā mea hoʻohui meaʻai, e hoʻomaʻamaʻa ʻia i ka pauku o kēia mau papa.

Hele mai nā ʻolua ʻenekinika a me nā pōkole insulin

I kēlā me kēia lā, ʻeha ʻia ka poʻe me ka maʻi type type 1 e hana i ka inikini a i ka ʻeha a me ka hōʻeha ʻana a i ʻole ke hoʻohana ʻana i nā pamu. Ua hoʻoikaika lōʻihi nā lāʻau lapaʻau me nā ala ʻoluʻolu e hoʻolōʻihi i ka hormone pono i loko o ke kahe wai, a he mea loaʻa ka hope o kekahi o lākou.

A hiki i kēia lā, ʻo ka poʻe me ka makaʻu o nā ʻōlelo hōʻemi ʻaʻole hiki i nā ʻano ʻē aʻe. ʻO kēia ka hopena maikaʻi loa e lawe i ka insulin ma o ka waha, akā ʻo ka pilikia nui ʻo ka hōʻemi ʻana i ka insulin i lalo loa i lalo o ka mana o ka wai o loko o ka gastric a me ka digestive enzymes. ʻAʻole hiki i nā ʻepekema ke lōʻihi lōʻihi ke hoʻomohala i kahi pūpū i mea e lanakila ai ka insulin i nā "āpau" o ke aʻai a komo i ke kahe koko.

A ʻo ka hope loa, ua hiki i nā kānaka ʻepekema mai Harvard ma lalo o ke alakaʻi ʻana a Samir Mitragotri i mea e hoʻoponopono i kēia pilikia. Ua paʻi ʻia nā hualoaʻa i kā lākou hana i loko o ka puke pai o ka US Academy of Science - PNAS.

Ua hiki i ka poʻe Biotechnologists ke hana i kahi pōpoki, lākou lākou e hoʻohālikelike ai i nā ʻano o ka versatility a me nā mākau me kahi pūʻali koa Swiss.

Hoʻokomo ʻia ka Insulin i kahi hui i kapa ʻia e nā mea kemika "wai ionic." ʻAʻole maʻamau ka wai, akā ma muli o kahi hiʻona haʻahaʻa loa, e ʻano ana me ka ʻano o ka wai. ʻO ka wai kaona i nā ʻano paʻakai, ka choline pūlea organik (huaʻai B4) a me ka huika geranium. E hui pū me ka insulin, ua hoʻopili ʻia lākou i ka membrane pale i ka waikawa o ka ʻōpū, akā hoʻokae ʻia i loko o kahi ʻāpana liʻiliʻi. Ma hope o ke komo ʻana i ka ʻōpū liʻiliʻi ʻole me ka pūpiki, ka hana ʻana o ka ionic me ke ʻano no ka insulin, pale iā ia mai ka loko o nā loko o ka ʻalohi ʻana, a, i ka manawa like, e kōkua ana ia i ke komo ʻana i ke kahe wai ma o ka paia o ka pāāia o ka ʻāʻī a o ka pūpū ponoʻī iho. ʻO kahi pōmaikaʻi ʻē aʻe o nā ʻōmaʻomaʻo me ka insulin i ka wai paʻakui he mea hiki ke mālama ʻia i ka lumi lumi no nā mahina ʻelua, e hōʻoluʻolu nui ʻia i ke ola o nā poʻe me ka maʻi maʻi.

Ua ʻike nā ʻepekema ʻepekema he maʻalahi a maʻalahi hoʻi e hana. Ma waho aʻe o ka mea e hiki ai i nā poʻe me ka maʻi diabetes me ka loaʻa ʻole o ka injected tedious, kaʻaina paha kēia ʻo ka lawe ʻana i ka insulin i ke kino e ʻoi aku ka maikaʻi. ʻO ka ʻoiaʻiʻo ʻo ke ala o ka hoʻohaʻahaʻa i ka hāmeʻa e hoʻohaʻahaʻa i ke koko me ka wai o ka ionic e like me nā kaʻina kūlohelohe o ka hemo i hana ʻia e ka pancreas ma mua o nā inikini.

Holoi hou ka ʻike ʻana i nā holoholona a aia wale nō ma luna o ka poʻe e koi ʻia e hōʻoia i ka palekana o ka lāʻau, akā naʻe, piha ka mea hoʻomohala. Hoʻohana ʻia ka choline a me ka geranic acid i ka hoʻohui i nā meaʻai, ʻo ia ka mea i ʻike ʻia he non-toxac, ʻo ia hoʻi, ʻo ka hapalua ia hana ua hana. Manaʻo nā mea hoʻolālā e kūʻai aku nā capsules i ka insulin i kekahi mau makahiki.