MANINIL 3

i loko o nā pahu pahu o 120 pcs., i kahi ʻeke pepa 1 pahu a i ʻole i loko o kahi mālamalama he 10 a 20 mau pcs.

i loko o nā pahu pahu o 120 pcs., i kahi ʻeke pepa 1 pahu a i ʻole i loko o kahi mālamalama he 10 a 20 mau pcs.

i loko o nā pahu pahu o 120 pcs., i kahi ʻeke pepa 1 pahu a i ʻole i loko o kahi pahu kī he 20 mau pcs., i loko o kahi pahu o nā pahu pepa 1, 2, 3, 4 a 6 paha blisters.

Lapaʻau lāʻau

Ma hope o ka nānāʻana i Maninil 3.5, kahi nānā wikiwiki a kokoke i piha o ka gastrointestinal tract. Hoʻokuʻu piha i ka microionized ikaika hana i loko o 5 mau minuke.
ʻO ka pilina protein Plasma he oi aku ma mua o 98% no Maninyl 3,5, 95%.
Ua aneane pau loa i ke kāʻei o ka ate me ka hoʻokumu ʻana o nā metabolites ʻelua i hana ʻia, kekahi o nā mea i hoʻopili ʻia e nā palaka, a me nā ʻē aʻe.
T1 / 2 no Maninyl 3.5 he 1.5-3.5 hola.

Ke ʻano o ka noi

Maninil 3.5 lawe ʻia ma ke kakahiaka, kakahiaka a me ke ahiahi, ma mua o ka ʻai ʻana, me ka ʻaika ʻole ʻole. Hoʻomoe ʻia ka pākēkē i kēlā me kēia, ma muli o ka nui o ka maʻi.
ʻO ka maʻa mua loa he 1 / 2-1 mau papa, ka ʻokoʻa ma 1 papa. i kēlā me kēia lā, kiʻekiʻe loa - 3, ma nā hihia kūikawā - 4 papa. i ka la.
ʻO nā palapala kau i kēlā me kēia lā a hiki i ka 2 papa. lawe pinepine ʻia i hoʻokahi manawa (i ke kakahiaka), kiʻekiʻe aʻe - mahele ʻia i 2 mau wai (kakahiaka a i ke ahiahi).

Nā hopena hopena

Hiki iā Hypoglycemia (me ka ʻai ʻana o ka ʻai, kahi overdose o ka lāʻau lapaʻau, me ka nui o ka hoʻoikaika kino, a me ka ʻai wai ʻona) nui ʻole.
Mai ka hanā hana ʻana: mau manawa - ka mualea, ka luaʻi ʻana, i kekahi mau hihia - jaundice cholestatic, hepatitis.
Mai ka ʻōnaehana hemopoietic: līpoki loa - thrombocytopenia, granulocytopenia, erythrocytopenia (a hiki i pancytopenia), i kekahi mau hihia - anemia hemolytic.
He maʻi kūloko: ʻaʻole i loaʻa pinepine - ka ʻupena o ka ʻili, ke kuni, ka ʻōpū, ka proteinuria.
Nā mea ʻē aʻe: i ka hoʻomaka ʻana o ka mālama ʻana, hiki i kahi maʻi noho hoʻololi ke hiki. I nā hanana pinepine, photosensitivity.

Nā Hoʻohui

Nā maʻi hoʻohālikelike i ka hoʻohana ʻana i ka lāʻau Maninil 3.5 nā: hypersensitivity (me nā huina sulfonamide a me nā derivatives sulfonylurea), type 1 diabetes mellitus (insulin-depend), decompensation metabolic (ketoacidosis, precoma, coma), ka moku'āina ma hope o ka hōʻoki o ka pancreatic, ʻeha pūpū a me nā maʻi o ka ʻōpū, kekahi nā hana ʻoi (no ka laʻana, decompensation o ka mea laʻa ka mea i kālai ʻia i ka maʻi lēʻaleʻa, ke puhi, nā hōʻeha a ma hope o nā hōʻeha nui ʻana i ka wā i hōʻike ʻia ai ka maʻi insulin), leukopenia, hana i loko o ka ʻōpū, paena. h ʻōpū, nā kūlana i hui pū ʻia me ka paʻa o ka ʻai a me ka hoʻomohala ʻana o ka hypoglycemia, hapai a me ka wā o ka umauma.

Hoʻopili pū me nā lāʻau ʻē aʻe

Ke hoʻoikaika nei i ka hopena hypoglycemic o ka lāʻau Maninil 3.5 hiki me ka hoʻohana pū ʻana me ACE inhibitors, nā ʻenekia a me nā hoʻonaninani kāne kāne, nā ʻaihue hypoglycemic oral (e.g., acarbose, biguanides) a me insulin, azapropazone, NSAID, beta-blockers, derivatives quinolone, chloramphenicol, clomofiber, disopyramide, fenfluramine, antifungal drug (miconazole, fluconazole), fluoxetine, MAO inhibitors, PASK, pentoxifylline (i nā kuono nui no ka hoʻokele makua ʻai), perhexiline, derivatives pyrazolone, ka phosphamides (e.g. cyclophosphamide, ifosfamide, trophosphamide), probenecid, salicylates, sulfonamides, tetracyclines a me tritoqualin.
Hoʻokomo ʻia nā ʻaihini e hoʻohuihui i ka urine (ammonium chloride, calcium chloride) i ka hopena o ka lāʻau Maninyl ma ka hoʻemi ʻana i ke kiʻekiʻe o kāna kipi a hoʻonui i kona reabsorption.
ʻO ka hopena hypoglycemic a Maninil hiki ke emi me ka hoʻohana pinepine ʻana o ka barbiturates, isoniazid, diazoxide, GCS, glucagon, nicotinates (ma nā helu koʻikoʻi), phenytoin, phenothiazines, rifampicin, thiazide diuretics, acetazolamide, hormones contraceptogen, estrogen hormones, estrogen hormones, estrogen hormones, estrogen hormones, estrogen nā mea hoʻonaninani o nā alani kalepa lohi, nā māka lithium.
Hiki ke hōʻalo i ka antagonist H2 maʻa, ma kekahi lima, a, ma kekahi, e hoʻoikaika i ka hopena hypoglycemic o Maninil.
I nā hihia pilikia, hiki i ka pentamidine ke hōʻeha i kahi hoʻonui nui a hoʻonui paha i ka kaila glucose wai.
Me ka hoʻohana like pū me ka lāʻau lapaʻau, hiki i Maninil ke hoʻonui a hoʻonāwaliwali paha i ka hopena o nā derivatives Coumarin.
Me ka hoʻonui ʻia o ka hana hypoglycemic, beta-blockers, clonidine, guanethidine a me ka reserpine, a me ka lāʻau me ka hoʻokūkū kūloko o ka hana, hiki ke hoʻonāwaliwali i ka manaʻo o nā hōʻailona o ka hypoglycemia.

Ke keu

Me ka holoʻana o ka hypoglycemia, hiki i ka mea maʻi ke hōʻalo i ka pale a me ka ʻike, ka hoʻomohala ʻana o ka comog hypoglycemic.
Hanaʻia: ma ka hihia o ka hypoglycemia maʻalahi, pono ka mea maʻi e lawe i kahi ʻāpana o ke kō, nā meaʻai a i ʻole nā ​​mea inu me kahi ʻona momona (ka meli, ka meli, kahi aniani o ke kīʻaha ʻona) i loko. I ka ʻike o ka nalowale o ka ʻike, pono ia e hoʻoili i ka glucose glucose - 40-80 ml o ka hopena o 40% dextrose (glucose), a laila infusion o 5-10% hopena o ka dextrose. A laila hiki iā ʻoe ke komo i ka 1 mg o ka glucagon i loko o / i, / m a i ʻole c / c. Inā ʻike ʻole ka mea maʻi i ka ʻike, a laila hiki ke hoʻomau i kēia ana; ʻoi aku ke koi ʻia o ka maʻi ikaika.

E hoʻokuʻu i ke ʻano

Maninil 3.5 - mau papa.
Kaki - i loko o nā hue wai o 120 pcs., I loko o kahi pā o ke kāleka ma 30 a 60 mau pcs.

1 papa Maninil 3.5 piha nā mea kanu: glibenclamide (ma ke ʻano micronized) 3.5 mg.
Nā mea kūlike: ka lactose monohala, kākoi huaʻai, gimetellosa, colloidal silicon dioxide, magnesium stearate, crimson dye (Ponso 4R) (E124)

Ka hana lāʻau lapaʻau

Loaʻa ia i nā hopena pancreatic a me ka extrapancreatic hopena. Hōʻike ʻia ka hana pancreatic i ka hoʻoulu ʻana o ka hana insulin e nā ʻenehana beta pancreatic, a hōʻike ʻia ka hana extrapancreatic i ka hoʻonui ʻana o ka naʻau o nā receptors insulin target (ma muli o ka hoʻohaʻahaʻa tyrosine kinase) i ka insulin, a me ka pani ʻana o ka gluconeogenesis a me ka glycogenolysis i loko o ka ate.

Lapaʻau Kauka

Hāʻawi ke ʻano Micronized i ka hoʻokō mua ʻana o C_max , kahi kūlike o ka hopena hypoglycemic e pili pono ana i ka piko o ka postgandial hyperglycemia, kahi e hōʻoia ai i ka hopena physiological o ia me ka hui pū me ka pōkole T_1/2 hōʻemi i ka hopena o ka hypoglycemia. ʻO ka pono o ka lā e pili ana i ka glibenclamide e hāʻule i ka 30-40%.

ʻO nā mea mālama palekana

Hoʻohana me ka mālama aka i ka hihia o ka febrile syndrome, ka maʻi thyroid (me ka hana ʻole i ke ahonui), hypofunction o ka anuition pituitary a i ʻole adrenal cortex, ʻalowa, i nā mea maʻi maʻi ma muli o ka ulu ʻana o ka ulu o hypoglycemia. Pono ʻia ke nānā kauka. I ka wā mālama, pono ʻoe e hahai i kahi meaʻai. ʻO ke lawe ʻana iā Maninil, ʻaʻole ia i hoʻololi i ka meaʻai. I ka wā o ka mālama ʻana, ʻaʻole i kuhikuhi ʻia e komo i nā hana e koi ai i ka piʻi ʻana a me ka wikiwiki o ka hopena psychomotor, e noho ai i ka lā no ka manawa lōʻihi. Pono kahi hoʻoponopono hoʻoponopono ʻia no ke ʻano kūlohelohe a me ke kaumaha, kahi hoʻololi i ka ʻai.

ʻO ka dosis a me ke ala o ka hoʻokele lāʻau.

Hoʻonohonoho ʻia ka ʻ individuallylelo i hoʻokahi, pili i ka makahiki, ke kaumaha o ka maʻi maʻi, ka wikiwiki o ka glycemia a me nā hola 2 ma hope o ka ʻai.

ʻO ka awelika maʻamau he 2.5-15 mg / lā, ʻo ka pinepine o ka hoʻokele he 1-3 mau manawa / lā. E lawe 20-30 mau minuke ma mua o ka papaʻaina. Ma nā wai i oi aku ma mua o 15 mg / lā, ua hoʻohana ʻia ia i nā hihia kaawale a ʻaʻole i kumu i ka hoʻonui nui ʻana o ka hopena hypoglycemic.

No nā poʻe maʻi maʻi, ʻo ka ma mua mua o ka 1 mg / lā.

Ke hoʻololi nei mai biguanides, ʻo ka iniha mua o ka glibenclamide he 2.5 mg / lā. Pono e hoʻokuʻu ʻia ʻo Biguanides, a me ke ʻano o ka glibenclamide, inā pono, hiki ke hoʻonui ʻia ma ka 2.5 mg i kēlā me kēia lā 5-6 e hiki ai ke hoʻopiʻi i ka pale o ka pilina o ka hoʻoneʻe. I ka hana ʻole o ka uku no nā wiki he 4-6, pono ia e hoʻolālā i ka hoʻohui ʻana i nā lāʻau lapaʻau me ka glibenclamide a me nā biguanides.

Nā hopena ʻaoʻao o Maninil 3.5:

Mai ka pūnaehana endocrine: hypoglycemia a hiki i ka uha (ʻoi aʻe ka ulu ʻana o kāna ulu ʻana me kahi kakala o ka dimen regimen me nā kīnā ʻole kūpono ʻole).

Nā maʻi kūlou: ʻāwili ka ʻili, ʻeha.

Mai ka pūnaehana hana ʻana: ka nausea, ka maʻi palu, ka manaʻo i ka kaumaha i ka wahi o ka epigastric, ʻaʻole i loaʻa - hana like ʻole i ka hana palupalu, cholestasis.

Mai ka ʻaoʻao o ka pūnaehana neoneo o ka pōkela a me nā ʻōnaehana hoʻoneʻe peripheral: luhi - paresis, hōʻeha o ka naʻau, ka hōʻeha, ka ʻōpū, nā nāwaliwali, haki.

Mai ka ʻōnaehana hematopoietic: loaʻa pinepine - nā maʻi hematopoiesis a hiki i ka hoʻomohala ʻana o ka pancytopenia.

Nā hopena dermatological: paʻakikī - photosensitivity.

ʻO nā ʻōlelo kūikawā no ka hoʻohana ʻana o Maninil 3.5.

Hoʻohana ʻia me ka mālama pono i nā poʻe maʻi me ka pathology o nā ate a me nā pōpilikia (me ka mōʻaukala), a me ka maka, ka maʻi adrenal function, thyroid gland, a me nā palaka hoʻonaninani.

I ka wā o ka papa hana, mālama pono ʻia ka hoʻokaʻina o ke koko a me ka lālia i kēlā me kēia lā.

Me ka hoʻomohala ʻana o ka hypoglycemia, inā ua ʻike ka mea maʻi, ua hoʻokaʻina (a i ʻole kahi hoʻoponopono o ke kō) paha i loko. I ka hihia o ka nalowale o ka ʻike, intravenous glucose a i ʻole glucagon sc, intramuscularly a i ʻole intravenously e lawelawe. Ma hope o ka loaʻa hou ʻana i ka naʻauao, pono e hāʻawi i ka mea maʻi i ka momona o ka mea laʻa i mea e pale ai i ka hoʻomohala hou ʻana o ka hypoglycemia.

ʻO nā mea maʻi e lawe ana i ka glibenclamide e pale i ka inu ʻana i ka wai inu. I ka hihia o ka inu ʻona, hiki i ka ulu ʻana o nā ʻano like ʻole o disulfiram, a me ka hypoglycemia koʻikoʻi.

Hoʻohui ʻia o Maninil 3.5 me nā lāʻau lapaʻau ʻē aʻe.

Ke hoʻoikaika nei i ka hopena hypoglycemic o ka glibenclamide me ka hoʻohana pū ʻana i nā beta-blockers, nā māka aatoma, allopurinol, cimetidine, clofibrate, cyclophosphamide, isobarin, MAO inhibitors, long-acting sulfonamides, salicylates, chloramphenicol, tetracycline, ethane.

ʻO ka nāwaliwali o ka hana o ka glibenclamide a me ka hoʻomohala ʻana i ka hyperglycemia hiki ke hoʻohana pū ʻia me nā barbiturates, chlorpromazine, fenothiazines, phenytoin, diazoxide, acetazolamide, glucocorticoids, sympathomimetics, glucagon, indomethacin, nui o nā kūmole, ʻenima, kūmole ʻaʻai, kūmole, kūmole, kūmole, kūmole nā'āpana kiʻekiʻe o ka laxatives.