Augmentin 125 papa: nā kauoha no ka hoʻohana ʻana

Nā Papa Hoʻohui, 500 mg / 125 mg a me 875 mg / 125 mg

Aia ma ka papa papa

mea waiwai: amoxicillin (as amoxicillin trihydrate) 500 mg a i ʻole 875 mg,

clavulanic acid (as potassium clavulanate) 125 mg,

nā mea hoʻowalewale: magnesium stearate, sodium starch glycolate type A, silicon dioxide colloidal anhydrous, microcrystalline cellulose,

ukana moku: titanium dioxide (E 171), hypromellose (5 cps), hypromellose (15 cps), macrogol 4000, macrogol 6000, hinu silicone (dimethicone 500).

500 mg / 125 mg papa

ʻO nā papa ʻaina i hoʻohālikelike ʻia i ke keʻokeʻo a keʻokeʻo i ke kala, i kahakaha ʻia me ka "A C" a notch ma ka ʻaoʻao hoʻokahi a hamama ma ka ʻaoʻao.

Nā Papa 875 mg / 125 mg

ʻO nā papa ʻaina i ʻōmaʻomaʻo mai ke keʻokeʻo a keʻokeʻo i ke kala, me kahi anaki ma nā ʻaoʻao a me ke kiʻi ʻia kahi "A C" ma nā ʻaoʻao ʻelua o ka pā.

ʻO nā waiwai Pharmacological

Phuhulokinetics

Hoʻopū maikaʻi ʻo Amoxicillin a me clavulanate i loko o nā hopena wai me ka pH physiological, ʻo nā mea ʻelua e wikiwiki a e a piha loa mai ka gastrointestinal tract ma hope o ka lawelawe waha. Hoʻohana nui ka nui o ka amoxicillin a me ka acid clavulanic i ka wā e lawe ai i ka lāʻau i ka hoʻomaka ʻana o kahi pāʻina. Ma hope o ka lawe ʻana i ka lāʻau lapaʻau i loko, ʻo kona bioavailability ʻo 70%. Hoʻohā like nā ʻaoʻao o nā mea ʻelua o ka lāʻau a hiki i ka piʻi ʻana o ka plasma kiʻekiʻe (Tmax) ma kahi o 1 hola. ʻO ka paʻa o ke amoxicillin a me ke kūpaʻa clavulanic i loko o ka serum koko e like nō me ka hana a ka hui o ka amoxicillin a me ka clavulanic acid, a me kēlā me kēia māhele i hoʻokaʻawale ʻia.

ʻO ka paʻa ʻana o ka amoxicillin a me clavulanic acid i nā protein plasma he maʻalahi: 25% no ka clavulanic acid a me 18% no ka amoxicillin. ʻO ka ʻike nui o ka hoʻoili e pili ana i 0.3-0.4 l / kg no ka amoxicillin a ma kahi o 0.2 l / kg no ka acid clavulanic.

Ma hope o ka hoʻōla ʻana ma hope, ua hoʻokuʻi ʻia nā hana therapeutic o ka amoxicillin a me ka clavulanic acid i nā ʻāpana ʻokoʻa a me nā ʻāpana, nā huakaʻi interstitial (pūpū, nā ʻōpū o nā ʻōpū, ke kīwī, adipose, nā iwi a me nā ʻāpana ʻāwīwā, pleural, synovial and peritoneal fluid, ka ʻili, ka ʻōpala, nā kuʻuna o purulent. huʻu). ʻO Amoxicillin a me clavulanic acid ʻaʻole i komo i loko o ka wai o cerebrospinal.

ʻO Amoxicillin, e like me ka hapa nui o nā penicillins, ua hoʻopili ʻia i ka umauma umauma. Loaʻa ka loaʻa o nā punawai clavulanic i nā umauma umauma. Me ka ʻokoʻa ʻole o ka loaʻa ʻana o ka naʻau, ʻo ka amoxicillin a me ka acid clavulanic ʻaʻole i hoʻopilikia i ka olakino o nā pēpē i hānai ʻia. ʻO Amoxicillin a me clavulanic acid e hoʻōla i ka paepae placental.

ʻO Amoxicillin i hoʻokaʻawale ʻia i loko o ka urine ma ke ʻano o ka waikawa penicillinic acid i loko o kahi nui e like me 10-25% o ka nui i lawe ʻia. Hoʻopili ka Clavulanic acid i ke kino i ka hoʻōla pālua a hoʻōla ʻia i ka urine a me nā feces, me ke ʻano o ka carbon dioxide ma o ka ea hanu.

Hoʻokomo ʻia ʻo Amoxicillin e nā ʻōpū, aʻo ka clavulanic acid i hoʻopili ʻia e nā ʻāpana a me nā kīʻaha extrarenal. Ma hope o ka hoʻoponopono waha waha o hoʻokahi papa o 250 mg / 125 mg a i 500 mg / 125 mg, ma kahi o 60-70% o amoxicillin a me 40-65% o ka clavulanic acid i hoʻololi ʻia i ka urine i ka 6 mau hola mua.

Ua hōʻoia ʻia nā ʻano like ʻole o ka hoʻopuka urinary he 50-85% no ka amoxicillin a me 27-60% no ka clavulanic acid i loko o 24 mau hola. No ka acid clavulanic, hoʻopuka ʻia ka nui o ka nui ma loko o nā hola 2 mua ma hope o ka hoʻokele ʻana.

ʻO ka hoʻohana ʻana o ka probenecid e hoʻolohi ana i ka hoʻopalehu o ka renxicillin renal, akā, ʻaʻole e lohi i ka hoʻopio ʻana o ka clavulanic acid me nā keiki.

Lapaʻau lāʻau

ʻO Augmentin® kahi hui lāʻau hoʻohui e kū ana me ka amoxicillin a me ka acid clavulanic, me kahi ākea ākea o ka hana bactericidal, kū i ka beta-lactamase.

Amoxicillin ʻO ka antibiotic semi-synthetic (beta-lactam), kahi ākea ākea kahi o ka hana, kahe i ka nui o nā microorganisms gram-maikaʻi a me ka gram-negatif.

ʻO ka hana o ka bactericidal o ka hana a ka amoxicillin e kāpae i ka biosynthesis o peptidoglycans o ka paia o ka paia o ke kino, ka mea e alakaʻi ai i ka lysis a me ka make o ka pūnaʻi.

ʻAi ʻia ka amoxicillin e luku ʻia e ka beta-lactamase e hua ʻia e nā maʻi kūweʻe, a no laila ke ʻano o ka microxismillin hana me ka microorganism e hana nei i kēia mau enzymes.

Clavulanic waikawa - Eia ka beta-lactamate, ka like me ka hana kemika i nā penicillins, ka hiki ke hana ʻole i nā enzyme beta-lactamase nā microorganism i kūʻē i nā penicillins a me cephalosporins, ma laila e pale ai i ka hana ʻole o ka amoxicillin. Hana ʻia nā hua Beta-lactamases e nā mea he nui i ka maikaʻi-gram a me ka bacteria. Hoʻopili ka Clavulanic acid i ka hana o nā kinina, hoʻihoʻi i ka naʻau o nā mea maʻi i ka amoxicillin. ʻO ka mea kūikawā, he hana kiʻekiʻe e kū'ē i ka plasmid beta-lactamases, kahi e pili pinepine ai ka pale ʻana i ka lāʻau, akā ua emi mai ka hopena e pili ana i ka type 1 chromosome beta-lactamases.

ʻO ka noho o ka acid clavulanic ma Augmentin® e pale i ka amoxicillin mai i nā hopena hoʻomāinoino o ka beta-lactamases a ke hoʻonui i ka pihi o nā hana antibacterial me ka hoʻopili ʻana o nā microorganism i kū pinepine i nā penicillins a me cephalosporins. Clavulanic acid i loko o ke ʻano o ka lāʻau hoʻokahi ʻaʻole i loaʻa ka hopena antibacterial koʻikoʻi.

Nā hana hoʻopiʻi kū'ē

Aia he 2 mau hoʻomana no ka hoʻolālāʻana o ke kū'ē i Augmentin®:

- ka hoʻohālikelike ʻana o ka bakela beta-lactamases, ka mea i paʻa ʻole i ka hopena o ka clavulanic acid, me nā papa B, C, D

- ka hoʻohuli ʻana i ka protein penicillin-nakinaki pū, e alakaʻi ana i ka emi ʻana o ka pilina o ka antibiotic i pili i ka microorganism

ʻO ka hemahema o ka paia bakalapa, a me nā mākaʻina o ka pulu, hiki ke hoʻoulu a ʻoluʻolu paha i ka hoʻomohala ʻana o ke kūpaʻa, ʻoi aku hoʻi i nā microorganisms gram-Negative.

Augmentin®loaʻa i ka hopena bactericidal ma kēia microorganisms i lalo:

Nā ʻākoakoa-Gram-maikaʻi: Bacillius anthracis,Enterococcus faecalis,ʻOhou palaʻai Gardnerella,Listeria monocytogenes, Nocardia asteroides,Staphylococcus aureus (ka manaʻo naʻau i ka methicillin), coagulase-negative staphylococci (ʻeha i ka methicillin), Streptococcus agalactiae,ʻO ka maʻi pīkoi streptococcus1,ʻO nā pyogenes Streptococcus a me nā beta hemolytic streptococci, hui ʻO nā wahine aliʻi Streptococcus,

Nā ʻĀpilikia kūwei: Actinobacillusactinomycetemcomitans,Capnocytophagaspp.,Eikenellacorrodens,Haemophilushoʻopuka,Moraxellacatarrhalis,Neisseriagonorrhoeae,Pasteurellamultocida

anaerobic microorganisms: ʻO nā huakini baki,Pula ka pepekeum Fusobacterium,Prevotellaspp.

ʻO Microorganisms me kahi mea e loaʻa ai ke kū'ē

Nā ʻākoakoa-Gram-maikaʻi: ʻO Kaukaʻāinakamaiki*

ʻO nā mikina me ke kūlohelohe kūlohelohe:

gram maikaʻiaerobes:Acinetobactermau ʻano,Citrobacterfreundii,Kauāʻāmau ʻano,Legionella pneumophila, Morganella morganii, Providenciamau ʻano, Pseudomonasmau ʻano, Serratiamau ʻano, Stenotrophomonas maltophilia,

nā: Chlamydia lachomatis,Chlamydophila pneumoniae, Chlamydophila psittaci, Coxiella burnetti, Mycoplasma pneumoniae.

1 ka waiho ʻana i nā kaha ʻO ka maʻi pīkoi streptococcuspenicillin kū kū

* ʻO ke kūlohelohe kūlohelohe i ka haʻalele ʻana o ka pale

Nā hōʻailona no ka hoʻohana ʻana

- ka sinusitis bakary sinus (me kahi hōʻike paʻa)

- maʻi huhū o ka pepeiao waena (ulia otitis media)

- ka ulu o ka bronchitis kūpaʻa (me ka hōʻoia paʻa)

- ka maʻi ʻehuleka huehue (cystitis, pyelonephritis)

- nā maʻi o ka ʻili a me nā lau palupalu (ma ke ʻano maʻamau, cellulite, ʻōpū manu, ʻili a me ke phlegmon o ka pae maxillofacial)

- nā maʻi o nā iwi a me nā ʻolua (ma ke ʻano he osteomyelitis)

ʻO nā ʻōkole maʻamau no ka hoʻohana kūpono ʻana i nā ʻenehana antibacterial e pono e noʻonoʻo ʻia.

ʻ a me ke kākele

Hiki paha i ka naʻau ke Augmentin® ke ʻano o ka wahi kiko a me ka manawa. Ma mua o ka kuhikuhi ʻana i ka lāʻau lapaʻau, inā hiki ke kūpono i ka loiloi ʻana o nā hana kuʻikuʻi e like me nā ʻikepili kūloko a hoʻoholo i ka ʻike ʻana ma o ka helu ʻana a me ka nānā ʻana i nā hiʻohiʻona mai kahi mea maʻi maʻi, ʻoi aku ka hopena o nā maʻi koʻikoʻi.

Hiki ke hoʻohana ʻia ʻo Augmentin® e hoʻomaʻamaʻa i nā maʻi i hoʻoiho ʻia e nā microorganisms kūpono i nā amoxicillin, a me nā maʻi hoʻowalewale i hoʻokumu ʻia e ka amoxicillin-a me nā clavulanate-sensitive e hana ana i ka beta-lactamase.

Ka hoʻonohonoho ʻai ʻana i ka dosage e waiho i kēlā me kēia kanaka i ka makahiki, ke kaumaha o ke kino, ka hana o ke keiki, nā ʻōpū paʻa ʻole, a me ka nui o ka maʻi.

No ka hōʻemi i ka hopena kūpono o ka piliʻana i ka pēpē gastrointestinal, ua noi ʻia ʻo Augmentin® e lawe ʻia me ka meaʻai i ka hoʻomaka ʻana o kahi ʻai no ka hoʻopili nui ʻana. Aia ka lōʻihi o ka lāʻau lapaʻau ma muli o ka pane a ka mea maʻi i ka mālama ʻana. Hiki i kekahi mau pathologies (ma keʻano he osteomyelitis) ke ʻano lōʻihi. ʻAʻole pono e hoʻomau i ka hoʻomehana no nā lā 14 me ka ʻole o ka loiloi ʻana i ke kūlana o ka mea maʻi. Inā pono, hiki iā ia ke hoʻokō i ka hana lapaʻau (neʻe mua, hoʻokele intravenous o ka lāʻau me ka hoʻololi hou ʻana i ka lawelawe waha).

ʻO nā pākeke a me nā keiki he 12 a keu paha ke kaupaona ʻana ma mua o 40 kg

Mahalo i ka maʻi hōʻeha (maʻi maʻamau)

1 papa 500 mg / 125 mg 2-3 mau lā i ka lā a i ʻole 1 papa 875 mg / 125 mg 2 mau manawa i ka lā

Nā maʻi hōʻeha (otitis media, sinusitis, haʻahaʻa ʻeha o ka ʻōpū, nā maʻi ʻeha o ka urinary)

1-2 papa 500 mg / 125 mg 3 mau lā i ka lā a i ʻole 1 papa 875 mg / 125 mg 2 a i ʻole 3 mau manawa i ka lā

ʻO ka palena nui o kēlā me kēia lā no nā pākeke a me nā keiki ma mua o 12 mau makahiki o ka hoʻohana ʻana i nā papa me kahi kaona o 500 mg / 125 mg he 1500 mg o ka amoxicillin / 375 mg o ka clavulanic acid. No nā papa me kahi kaʻe o 875 mg / 125 mg, ʻo ka nui loa o ka lā ma kēlā me 1750 mg o ka amoxicillin / 250 mg o ka clavulanic acid (i ka manawa e lawe i ka 2 manawa i ka lā) a i ʻole 2625 mg o ka amoxicillin / 375 mg o ka clavulanic acid (i ka manawa i lawe ʻia i 3 mau lā i ka lā).

ʻO nā keiki ma lalo o 12 a kaupaona paha e emi iho ma lalo o 40 kg

ʻAʻole kuhi ʻia kēia palapala maʻi no nā keiki ma lalo o 12 mau makahiki a i ʻole e kaupaona ʻia nā keiki ma lalo o 40 kg. Kuhi ʻia kēia mau keiki iā Augmentin® i ke kāohi ʻana no ka lawelawe ʻana ma ka waha.

ʻO ka maʻi me ka hana renal impaired

Kuhi ʻia ka hoʻoponopono ʻana i ka Dosis i ka nui o ke koena o ka amoxicillin a me ka helu clearance creatinine.

Augtionin dosage regimen®

ʻAʻole koi ke hoʻoponopono ʻia

1 papa 500 mg / 125 mg 2 mau lā i ka lā

30 ml / min. Nā maʻi maʻi Hemodialysis

Kuhi ʻia ka hoʻoponopono ʻana i ka dosis ma ka nui o ke ʻano loiloi ʻo amoxicillin.

Nā ʻōpio: 1 papa 500 mg / 125 mg i kēlā me kēia 24 hola Kālai koho Ua kuhikuhi ʻia ka ʻaihue 1 i ka wā dialysis a me kahi ʻano ʻē aʻe ma ka hopena o ka hālāwai dialysis (e hoʻihoʻi i ka hoʻemi ʻana o ka serum konsentrasi o ka amoxicillin a me ka clavulanic acid).

Pono ka papa o nā papa me 875 mg / 125 mg wale nō e hoʻohana i nā mea maʻi me ka clearance creatinine> 30 ml / min. ʻO nā maʻi me ka hana pūlima hemahema

Hoʻololi ʻia ka hana maʻi me ka akahele;

Hoʻemi i ka Dose Augmentin® ʻaʻole pono, ʻaʻole like nā dosis me nā pākeke. I ka poʻe maʻi nā maʻi me ka hana renal impaired, pono e hoʻoponopono ʻia ka nui e like me ka mea i hōʻike ʻia ma luna nei no ka poʻe pākeke me ka hana ʻole kīnā.

Nā hopena hopena

Hoʻomaopopo ʻia nā hopena ʻaoʻao i loko o nā hoʻokolohua hoʻokolohua a ma i ka wā ma hope o ke kūʻai ʻana ke kūʻai ʻia a helu ʻia ma muli o ka hoʻonaninua anatomical a me ka physiological a me ka pinepine o ka hanana.

Ka hoʻoholo ʻia ʻana o ka hanana e like me kēia penei: pinepine pinepine (≥1/10), pinepine (≥1 / 100 a

E hoʻokuʻu i ke ʻano

Ke hōʻike ʻia nei ka lāʻau lapaʻau i nā palapala hoʻoiho:

• ʻO nā papa o Augmentin 250 mg + 125 mg, Augmentin 500 mg + 125 mg a me Augmentin 875 + 125 mg.
• ʻO Powder 500/100 mg a me 1000/200 mg, i manaʻo ʻia no ka hoʻomākaukau ʻana i kahi hopena no ka hoʻonā.
• ʻO ka Powder no ka hoʻokuʻuʻana iā Augmentin 400 mg / 57 mg, 200 mg / 28.5 mg, 125 mg / 31.25 mg.
• ʻO Powder Augmentin EU 600 mg / 42.9 mg (5 ml) no ka hoʻopiʻi.
• Augmentin CP 1000 mg / 62.5 mg paʻa mau hoʻokuʻu papa

Pharmacodynamics a me ka pharmacokinetics

Wahi a Wikipedia, ʻo Amoxicillin ʻo ia mea hoʻonāukiukikūleʻa e kūʻē i kahi ākea ākea o ka pathogenic a me ka pathogen pathogen nā mea ʻaanaka a me nā inoa nā semicnthetic penicillin group antibiotic.

Kālā manaʻo transpeptidase a hoʻonāukiuki i nā kaʻina hana mureina (ka mea koʻikoʻi ka pā o nā paia o nā pūpū bakela) i ka manawa o ka hoʻokaʻawale ʻana a me ka ulu ulu, e hoʻoulu ana i ia lysis (luku) nā pepeke.

Ua luku ʻia ʻo Amoxicillin β-lactamasesno laila ʻaʻole ia e hoʻonui i kāna hana antibacterial nā mea ʻaanakahana ʻana β-lactamases.

E hana ana i ka hoʻokūkū a ma ka hapa nui loa he mea ke hoʻololi ʻole ʻia. kāmele clavulanic hōʻike ʻia e ka hiki ke komo i nā paia o nā kelepona nā pepeke a lilo i ka hana ʻole ʻaʻano enehanaaia ma ke kahua kahi a me kona mokuna.

Clavulanate hana paʻa i nā paʻakikī paʻakikī β-lactamasesa ma keia e pale aku ai i ka luku pauxicillin.

Hoʻomaʻaʻa ka antibiotika o Augmentin i:

• Uwapo (+) aerobes: pyogenic kenia nā hui A a me B, ʻo ka pīkococci, Staphylococcus aureus a me epidermal, (me ka ʻokoʻa ʻole o nā kumu lāʻau i kū i ka methicillin), sapaphopoly staphylococcus me nā mea ʻē aʻe
• ʻAnoʻula (-) aerobes: Lāʻau lāʻau Pfeiffer, wai lāloʻi, hāhā i kūlohelohe , kolera vibrio etc.
• Gram (+) a me Gram (-) nā anaerobes: nā huakini, ōpiopio, kahakaluleetc.
• Nā microorganisms ʻē aʻe: chlamydia, hoʻowahāwahā, pale treponema etc.

Ma hope o ka nānāʻana iā Augmentin, ʻo nā mea hana ʻelua e hopu koke i ke kīpē. Kūpono ka maikaʻi o ka Absorption inā he inu a nā ʻōpū paha i ka wā o kahi pāʻina (ma ka hoʻomaka ʻana o kahi pāʻina).

ʻO ka mea e lawe ʻia i ka waha, a me ka hoʻopuka ʻana mai i ka hopena o Augmentin IV, ʻike ʻia ka therapeutic o nā mea ikaika o ka lāʻau lapaʻau i ʻike i nā kiko āpau a me nā ʻano interstitial.

ʻO nā papa hana ʻelua i nā nāwaliwali a paʻa loa Nā protein koko (a piʻi i ka 25% e hoʻopili ai i nā protein plasma amoxicillin trihydrateaole oi aku mamua o ka 18% kāmele clavulanic) ʻAʻohe kumuhua o Augmentin i ʻike ʻia i loko o nā ʻāpana o ke kino.

Amoxicillin ʻikea ka hoʻonele ʻana i ke kino a hoʻopio ʻia nā pōpōma o ka digestive tract a me ke ano o ke kalapona a me ka ea hooneʻe. 10 ke 25% o ka maʻi i loaʻapauxicillin ua hoʻopaneʻe nā pōpō i ke ano penicilloic acidʻo kāna mea e hana ʻole ai hoʻonanea.

Clavulanate ua hoʻopiʻi ʻia e nā ʻāpana a me nā ʻoi aku o nā mīkini extrarenal.

Nā Hoʻohui

ʻAiau ʻia ʻo Augmentin i nā ʻano āpau a pau:

• nā mea maʻi me ka hypersensitivity i kekahi a i ʻole nā ​​mea ʻelua o ka lāʻau i ka lāʻau, i kekahi o nā mea hoʻokani pila, e like me β-lactam (i.e. ka antibiotika mai nā hui penicillin a cephalosporin),
• nā mea maʻi i loaʻa i nā hopena episode o Augmentin therapy jaundice a i kekahi moʻolelo o ka hana hōʻino nā ate ma muli o ka lilo o kahi hui o nā mea ikaika o ka lāʻau.

ʻO kahi contraindication hou i ke koho ʻana i kahi lāʻau no ka hoʻomākaukau ʻana i kahi hoʻopiʻi waha i ka waha o kekahi mau mea ikaika o 125 + 31.25 mg ʻo PKU (phenylketonuria).

ʻO ka paura i hoʻohana ʻia no ka hoʻomākaukau ʻana i ka hoʻopiʻi ʻana i ka waha me ka ʻai ʻana o nā mea ikaika (200 + 28.5) a me (400 + 57) mg, ua contraindicated:

• ma PKU,
• maʻi nā maʻi ʻōpalai nā hōʻailonaNā hōʻike hōʻike Reberg ma lalo o 30 ml mau minuke
• keiki malalo o na makahiki ekolu.

ʻO kahi contraindication hou i ka hoʻohana ʻana i nā papa me kahi kaʻi ʻia o nā mea ikaika (250 + 125) a me (500 + 125) mg ka makahiki ma lalo o 12 mau makahiki a / a i ʻole ke kaumaha ma lalo o 40 kilograms.

Nā pālapa me ka nui o nā mea hoʻonaninani 875 + 125 mg:

• i ka hōʻahewa ʻia o ka hana hana ʻōpala (nā hōʻailona Nā hōʻike hōʻike Reberg ma lalo o 30 ml mau minuke)
• keiki malalo o 12 makahiki
• i nā maʻi nā mea i kaupaona ʻia ma mua o 40 kg.

Nā ʻōkuhi no ka hoʻohana ʻana iā Augmentin: ʻano hana, dosage no nā mea maʻi a me nā keiki

ʻO kekahi o nā nīnau nīnau pinepine a ka maʻi maʻi ʻo ia ka nīnau e lawe ai i kahi lāʻau lapaʻau ma mua a ma hope o ka ʻaina. I ka hihia o Augmentin, lawe ʻia ka lāʻau lapaʻau e pili pono ana i ka ʻai ʻana. Ua manaʻo ʻia e lawe pololei i ka lāʻau lapaʻau. ma mua o ka ʻaina.

ʻO ka mea mua, hāʻawi iā ia i ka maikaʻi o ke komo ʻana o kā lākou mau mea ikaika ʻŌpala Gastrointestinala, ʻo ka lua, hiki iā ia ke hoʻemi i ka hōʻino nui nā maʻi dyspeptic o ka ʻeha gastrointestinalina o ka hope ka hope.

Pehea e helu ai i ka helu o Augmentin

Pehea e lawe ai i ka lāʻau lapaʻau Augmentin no nā pākeke a me nā keiki, me kona ʻano therapeutic, ma muli o ia microorganism he pathogen, pehea ke ʻano o ka pālahalaha ʻana nā maʻi maʻi, ka ʻeha a me nā ʻano o ka hele o ka maʻi, lokahi o ka ʻōpū paʻa ʻana, nā makahiki a me ke kaumaha o ka mea maʻi, a me kona ʻano maikaʻi hoʻi nā pōpō ka mea maʻi.

Pono ka lōʻihi o ka papa o ka lāʻau lapaʻau ma muli o ke ʻano o ke kino o ka mea maʻi i ka mālama ʻana.

Nā papa ʻāina Augmentin: ʻōlelo aʻoaʻo no ka hoʻohana ʻana

Wahi a nā ʻike o nā mea ikaika i loko o lākou, ua ʻōlelo ʻia nā papa o Augmentin e lawe ʻia e nā maʻi maʻi e like me kēia ʻano hana:

• Augmentin 375 mg (250 mg + 125 mg) - ʻekolu manawa i ka lā. I kahi ʻano kikoʻī, hōʻike ʻia ka lāʻau lapaʻau no nā hopena maʻie kahe ana maloko maʻalahi a i ʻole ʻano maʻalahi. I nā hihia o nā maʻi koʻikoʻi, me ke komo ʻana a me ka huli hou ʻana, e kau ʻia ana nā kaha kiʻekiʻe.
• 625 mg papa (500 mg + 125 mg) - ʻekolu manawa i ka lā.
• 1000 mg papa (875 mg + 125 mg) - hoʻokahi ʻelua i ka lā.

Hoʻopilikia ʻia kēia ʻōlelo ma ka hoʻoponopono ʻana i nā poʻe maʻi me ka hana hoʻoikaika kino. ʻōpala.

ʻAi ʻia ka Augmentin CP 1000 mg / 62.5 mg e hoʻokuʻu ʻia ana nā papa no ka poʻe maʻi ma mua o nā makahiki 16. ʻO nā papa maikaʻi loa he ʻelua papa ʻelua i ka lā hoʻokahi.

Inā hiki ʻole i ka mea maʻi ke hoʻomāki i ka papa āpau, ua mahele ʻia i ʻelua ma ke laina o ka hewa. Lawe ʻia nā ʻāpana ʻelua i ka manawa like.

ʻO nā mea maʻi me nā maʻi nā pōpō Kau ʻia ka lāʻau lapaʻau i loko o nā hihia wale nō kahi mea e kuhikuhi ai ka hōʻailona Nā hōʻike hōʻike Reberg uaʻoi aku ka 30 ml i hoʻokahi minuke (ʻo ia hoʻi, ʻaʻole pono ka hoʻoponopono ʻia o ka regimen dosage).

Pauku no ka hoʻonā ʻana no ka inikini: nā ʻōlelo no ka hoʻohana ʻana

Wahi a nā ʻōkuhi, e hoʻonā ʻia ka hopena i loko o ka vein: ma o ka jet (pono ke hoʻokaʻawale ʻia ke ʻano holoʻokoʻa i nā minuke 3-4) a i ʻole e ke ʻano hana wai (hala infusion - mai ka hapalua hola a 40 mau minuke). ʻAʻole kūpono ka hoʻonā e hoʻonā ʻia ʻana ma ka ʻiʻo.

ʻO ka palena maʻamau no ka maʻi pākeke ʻo 1000 mg / 200 mg. Hoʻolaha ʻia e komo i loko o kēlā me kēia mau hola ʻewalu, a no nā mea i hoʻopiʻi ʻia nā hopena maʻi - kēlā me ʻeono a i ʻole paha ʻehā mau hola (e like me nā hōʻike).

Antibiotic i ke ʻano o kahi hoʻonā, 500 mg / 100 mg a i ʻole o 1000 mg / 200 mg i kuhikuhi no ka pale ʻana i ke kūkulu ʻana maʻi ʻana ma hope o ka ʻoihana. ^ E Ha yM. I nā hihia kahi i emi iho ai ka lōʻihi o ka manawa i ka hola hoʻokahi, ua lawa ia e komo i ka mea maʻi i hoʻokahi manawa ma mua anesthesia ka nui o Augmentin 1000 mg / 200 mg.

Inā manaʻo ia e noho hou ka hana ma mua o hoʻokahi hola, a hiki i ka 4 mau dosis o 1000 mg / 200 mg e lawelawe ʻia ana i ka mea maʻi ma ka lā ma mua no 24 mau hola.

Hoʻopaʻa Augmentin: nā ʻōlelo no ka hoʻohana ʻana

Ke kauoha aku nei no ka hoʻohana ʻana iā Augmentin no nā keiki e noi ana i ke koho ʻana o ke kāpena ʻana i ka lā 125 mg / 31.25 mg ma kahi pākaʻi o 2.5 a 20 ml. Nā ʻano apo - he 3 i ka lā. Pākuʻi ka nui o kahi pākahi i nā makahiki a me ke kaumaha o ke keiki.

Inā ʻoi aku ka maʻa o ke keiki ma mua o ʻelua mau makahiki o ke kau ʻana, ua hoʻokuʻu ʻia ka pona ʻana i ka 200 mg / 28.5 mg ma ka lāʻau e like me 25 / 3.6 mg a 45 / 6.4 mg no 1 kg o ka paona o ke kino. Pono e hoʻokaʻawale ʻia ka nui o ka mahele kikoʻī ma ʻelua mau dosis.

Hoʻopaʻa iki ka hoʻokaʻawaleʻana o nā waiwai ikaika 400 mg / 57 mg (Augmentin 2) i hōʻike ʻia no ka hoʻohana ʻana mai ka makahiki. Kūlike i ka makahiki a me ke kaupaona ʻana o ke keiki, hoʻokahi ka lāʻau hoʻokahi i 5 mai ka 10 ml. Nā ʻano apo - 2 i ka lā.

Ua kauoha ʻia ʻo Augmentin EU e hoʻomaka mai ka 3 mau makahiki o ka makahiki. ʻO ka maʻa mau loa he 90 / 6.4 mg i 1 kg o ka paona o ke kino i kēlā me kēia lā (pono e hoʻokaʻawale ʻia ka mahele i 2 mau dosis, e mālama ana i kahi kikowaena 12-mau ma waena o lākou).

I kēia lā, ʻo ka lāʻau lapaʻau i loko o nā ʻano hana like ʻole kekahi o nā mea inikua no ka lapaʻau ʻana. ʻūhā ʻeha.

ʻO nā keiki Augmentin me ʻeha ka ʻeha i kuhikuhi ʻia ma kahi pāʻālua i hoʻoholo ʻia e pili ana i ke kaumaha kino a me ke ʻano o ke keiki. Me ka angina i nā pākeke, ua ʻōlelo ʻia e hoʻohana iā Augmentin i 875 + 125 mg ʻekolu mau manawa i ka lā.

Eia kekahi, hele pinepine lākou i ke koho iā Augmentin sinusitis. ^ E Ha yM. Hoʻohui ʻia ka mālama ʻia e ka holoi ʻana i ka ihu me ka paʻakai o ke kai a me ka hoʻohana ʻana i nā puna wai o ke ʻano o ke ʻano Rinofluimucil. ^ E Ha yM. Nā kaha kūpono no sinusitis: 875/125 mg 2 manawa i ka lā. ʻO ka lōʻihi ka papa o ka papa he 7 mau lā.

Ke keu

ʻO ka hoʻokuʻuʻana i ka maʻi o Augmentin i ukali ʻia me:

• ka hoʻomohala ʻana o nā ka hana ʻino ʻana e kalalā,
• ka haki ʻana i ke koena wai-paʻakai,
• crystalluria,
• pilikia kūlohelohe,
• uulit (kulu) of amoxicillin in the urinary catheter.

Ke hōʻike ʻia kēia mau ʻōuli, hōʻike ʻia ka mea maʻi i ka therapyaticatic, me ka mea, ma waena o nā mea ʻē aʻe, ka hoʻoponopono ʻana o ka palekana wai-paʻakai i hoʻopiʻi ʻia. Haawe o Augmentin mai iʻōnaehana kaulike hoʻoikaika i ke kaʻina hana hemodialysis.

Hoʻohui

• kōkua e hōʻemi kikowaena tubular o ka amoxicillin,
• hoʻonāukiuki i ka hoʻonui ʻana o ka hoʻoili pauxicillin i loko pili koko (ke hoʻomau nei ka hopena)
• ʻaʻole pili i ka waiwai a me ka pae o ka ʻike i loko clavulanic waikawa plasma.

Kahiʻa pauxicillin me allopurinol hoʻonui i ka hiki ke hoʻomohala i nā hōʻike nā pepeke. ^ E Ha yM. ʻIkepili pili allopurinol i ka manawa like me nā hana ʻelua no Augmentan i kahi hala.

He hopena maikaʻi ʻo Augmentin ma loko o ka ʻāwīwī ʻōpala microflorae hoʻonāukiuki ai i ka emi ʻana o ka hakahaka (reversorption) estrogen, me ke emi ʻana o ka hopena o ka hui pū ʻana ʻohiʻohi no ka hoʻohana waha.

ʻAʻole hoʻohui ʻia ka lāʻau lapaʻau me nā huahana koko a me nā ʻano wai hoʻomalu o ka protein, me nā komo whey protein hydrolysates a me nā momona momona i manaʻo ʻia e hoʻokomo i loko o kahi vein.

Inā ʻōlelo ʻia ʻo Augmentin i ka manawa like antibiotika papa kaʻaoglikua, ʻaʻole i kāwili ʻia nā lāʻau lapaʻau i loko o kahi syringe a i ʻole nā ​​mea ʻē aʻe ma mua o ka hoʻokele ʻana, ʻoiai e alakaʻi ana kēia kaʻaoglikua.

Nā kuʻina o Augmentin

ʻO nā analogs Augmentin i nā lāʻauʻO A-Klav-Paʻaka, Amoxiclav, Amoxil-KBetaclava Clavamitin, Medoclave, Teraclav.

ʻO kēlā me kēia lāʻau lapaʻau i luna ka mea e hiki ke hoʻololi ʻia ʻo Augmentin i kona haʻalele ʻole ʻana.

Hoʻololi ʻia ke kumukūʻai o nā panāila mai 63.65 a 333.97 UAH.

ʻO Augmentin no nā keiki

Hoʻohana nui ʻia ʻo Augmentin i ka hana maʻi pediatric. Mamuli o nā mea i loaʻa i kahi keiki i hoʻokuʻu ʻia - syrup, hiki ke hoʻohana ʻia i ka mālama i nā keiki a hoʻokahi makahiki. Hoʻonui maʻalahi i ka hoʻokipa a me ka ʻoiaʻiʻo no ka ʻoluʻolu nā lāʻau lapaʻau.

No na keiki nā maʻi maʻii hōʻike pinepine ʻia no ʻeha ka ʻeha. ^ E Ha yM. Hoʻoholo ʻia ka nui o ka hāʻule ʻana o nā pēpē no nā makahiki a me ke kaumaha. Ua mahele ʻia ka nui o ka hopena ma mua o nā ana ʻelua, e like me 45 mg / kg i kēlā me kēia lā, a i ʻoka ʻia i ʻekolu mau pūmole, kahi kūpapa o 40 mg / kg i kēlā me kēia lā.

Pehea e lawe ai i ka lāʻau lapaʻau no nā keiki a ʻo ke alapine o nā maʻi kaukaʻi ʻia ma ka ʻano lāʻau i kuhikuhi ʻia.

No nā keiki i ʻoi aku ke kaumaha o ke kino ma mua o 40 kg, ua kauoha ʻia ʻo Augmentin i nā ʻano like me nā mea maʻi maʻi makua.

ʻO Augmentin syrup no nā keiki a hiki i ka makahiki ke hoʻohana ʻia i loko o nā inika o 125 mg / 31.25 mg a me 200 mg / 28.5 mg. Kuhi ʻia ka nui o 400 mg / 57 mg no nā keiki no hoʻokahi makahiki o hoʻokahi makahiki.

Manaʻo nā keiki i nā makahiki o 6-12 mau makahiki (ke kaupaona ʻana ma mua o 19 kg) e kuhikuhi i ka hoʻokuʻu a me Augmentin i nā papa. ʻO ka ʻōlelo palena nui o ke ʻano papa o ka lāʻau lapaʻau e like me kēia:

• papa hoʻokahi 250 mg + 125 mg ʻekolu mau lā i ka lā,
• hoʻokahi papa 500 + 125 mg papalua i hoʻokahi lā (ʻoi aku ka maikaʻi o kēia ʻano).

ʻO nā keiki ma mua o 12 mau makahiki ua kau ʻia e lawe i hoʻokahi papa o 875 mg + 125 mg papalua i ka lā.

No ke ana pololei i ka pae ʻana o ka ʻaina Augmentin no nā keiki ma lalo o 3 mau makahiki o ka makahiki, ʻoi ʻia ke kuhi ʻana i ka papa tirika me kahi syringe me kahi pae hōʻailona. I mea e hoʻomaʻamaʻa ai i ka hoʻohana ʻana o ke kaʻaā i nā keiki ma lalo o ʻelua makahiki he ʻae ʻia, e ʻae ʻia e hoʻoheheʻe ʻia ke kōkī me ka wai ma kahi pānaʻi o 50/50

ʻO nā mea kikoʻī o Augmentin, kahi mea hoʻohālikelike o ka lāʻau lapaʻau Amoxiclav, Flemoklav Solutab, ʻAlona, ʻO Rapiclav, Ecoclave.

Hoʻolaha ka waipuna

ʻAʻole ʻike nā Augmentin a me ka waiʻona i nā antagonist ma lalo o ke ʻano o ka hopena etil nā maʻi maʻiʻaʻole e hoʻololi i kāna mau lāʻau lapaʻau.

Inā kū'ē i ke kua o ka lāʻau lapaʻau e pono ka inu ʻana i ka waiʻona, he mea nui e nānā i nā ʻano ʻelua: hoʻololi a kūpono hoʻi.

No nā poʻe e loaʻa nei i ka hilinaʻi ʻana i ka waiʻona, hiki i ka hoʻohana pinepine ʻana o ka lāʻau me ka waiʻona hiki ke loaʻa i nā hopena koʻikoʻi.

Hoʻonāukiuki ka hoʻonāukiuki ʻana o ka ʻona huhū i nā ʻano hana like ʻole nā ate. ^ E Ha yM. ʻO ka maʻi me ka mea maʻi nui ka ate ke kauoha aku nei ke aʻoaʻo e hoʻokaʻawale ʻia ʻo Augmentin me ka akahele loa, no ka mea ua wānana ʻia ka ʻano o ka maʻi maʻi i ka hoʻāʻo ʻana e hoʻokūkū.xenobioticpaʻakikī loa.

No laila, i mea e pale aku ai i ka pīpī, ʻaʻole pono e hōʻole i ka inu ʻawaʻī i ka wā holoʻokoʻa holoʻokoʻa me ka lāʻau lapaʻau.

Augmentin i ka wā hāpai a me ka lactation

E like me ka hapanui o nā antibiotika hui penicillin, pauxicillin, ka helu ʻia i loko o nā pāna o ke kino, ke komo pū i loko o ka waiū umauma. Eia kekahi, ʻike pū ʻia nā ʻūlaki ma mua o ka waiū. kāmele clavulanic.

Eia naʻe, ʻaʻohe hopena koʻikoʻi o ka maʻi e pili ana i ke kūlana o ke keiki. I kekahi mau hihia, ʻo ka hui pū ʻana kāmele clavulanic me pauxicillin hiki ke hoʻonāukiuki i kahi pēpē nā ninia a me / kandidiasis (ʻūhū) o nā membrane mucous i ka waha waha.

Aia ʻo Augmentin i keʻano o nā lāʻau lapaʻau i ʻae ʻia no ka ʻōpū. Inā naʻe, ma muli o ke ʻano o ka mālama ʻana o ka makuahine me Augmentin, hoʻomohala ʻia ke keiki i kekahi mau ʻaoʻao o ka maikaʻi, e pau ka mālama umauma.

Ua hōʻike nā haʻawina holoholona i nā mea ikaika o Augmentin i hiki ke komo hematoplacental (GPB) pani ʻia. ^ E Ha yM. Eia naʻe, ʻaʻohe mau hopena maikaʻi e pili ana i ka hoʻomohala ʻana i ka pēpē.

Eia kekahi, ʻaʻole i pili nā hopena teratogenic me ka makua a me ka hoʻoponopono waha o ka lāʻau.

ʻO ka hoʻohana ʻana iā Augmentin i nā wahine hāpai hiki a alakaʻi i ke kūkulu ʻana i kahi pēpē hānau hou necrotizing enterocolitis (NEC).

E like me nā lāʻau āpau a pau, ʻaʻole i hāʻawi ʻia ʻo Augmentin i nā wahine hāpai. I ka wā hāpai ʻia, ʻae ʻia ka hoʻohana ʻana i nā hihia i laila, e like me ka loiloi a ke kauka, ʻo ka pono no ka wahine ke ʻoi aku i nā pōpilikia no kāna keiki.

Nā manaʻo e pili ana iā Augmentin

Hōʻikeʻike i nā papa a me nā hoʻokaʻawale i nā keiki Augmentin no ka hapa nui kū maikaʻi. ^ E Ha yM. He nui ka loiloi i ka lāʻau lapaʻau he hopena kūpono a kūlike ia.

Ma nā papa kūkala ma nā wahi e kaʻana o ko lākou manaʻo i kekahi mau lāʻau lapaʻau, ʻo ka makeʻana o ka maʻi antibiotic ka maʻi ma o 4.4-4.5 mau o 5 mau kikoʻī.

ʻO nā loiloi e pili ana iā Augmentin i waiho ʻia e nā makuahine o nā keiki ʻōpio e hōʻike ana i ke kōkua ʻana o ke mea kōkua i ka maʻi maʻamau ma mua o nā maʻi ʻOluomini a i ʻole ʻeha ka ʻeha. ^ E Ha yM. Hoʻopiliʻia ma kahi o ka hopena o ka lāʻau lapaʻau, ʻike pū kekahi mau makuahine i kona leʻaleʻa maikaʻi, e like me ka poʻe keiki.

He maikaʻi loa ka mea hana i ka wā hāpai. ʻOiai ka mea ʻole o ke aʻo e aʻo nei i ka mālama ʻana i nā wahine hāpai (ʻoi aku hoʻi i ka 1st trimester), kauoha pinepine ʻia ʻo Augmentin i ka mea hana 2 a me 3 mau mea hoʻomaʻamaʻa.

Wahi a nā kauka, ʻo ka mea nui i ka wā e mālama ai me kēia hāmeʻa, ʻo ka mālama ʻana i ke kūpono o ka dosage a hahai i nā ʻōlelo a pau a kāu kauka.

Hōʻike Augmentin

Kūlike ke kumukūʻai o Augmentin ma Ukraine, ma muli o kahi lāʻau lapaʻau kūikawā. I ka manawa like, ʻoi aku ka nui o ke kumukūʻai o ka lāʻau lapaʻau ma ke kīpī ma Kiev, nā papa liʻiliʻi a me ke kōpaʻa i loko o nā lāʻau lapaʻau ma Donetsk, ʻo Odessa a me Kharkov ke kūʻai aku nei ma ka kumukūʻai haʻahaʻa.

625 mg papa (500 mg / 125 mg) ua kūʻai aku i nā lāʻau lapaʻau, ʻokoʻa, ma 83-85 UAH. ʻO ke kumukūʻai kumukūʻai o nā papa Augmentin 875 mg / 125 mg - 125-135 UAH.

Hiki iā ʻoe ke kūʻai i kahi antibiotic i loko o ka pauka form no ka hoʻomākaukau ʻana i kahi hopena no ka hoʻonā ʻana me kahi maʻi 500 mg / 100 mg o nā mea ikaika, ma ka awelika, no 218-225 UAH, ka uku kumu kūʻai o Augmentin 1000 mg / 200 mg - 330-354 UAH.

Kumukūʻai o Augmentin suspension no nā keiki:
400 mg / 57 mg (Augmentin 2) - 65 UAH,
200 mg / 28.5 mg - 59 UAH,
600 mg / 42.9 mg - 86 UAH.

Nā hana hana i ka hana

ʻO Amoxicillin kahi antibiotic ākea ākea ākea me ka hana e kūʻē i nā microorganisms gram-maikaʻi a me ka gram-negatif. I ka manawa like, hiki i ka amoxicillin ke hōʻemi nei i ka luku, e nā beta-lactamases, a no laila ke kahe mai o ka hana o ka amoxicillin e hoʻopili i nā microorganism e hana nei i kēia enzyme.

ʻO Clavulanic acid, kahi beta-lactamase inhibitor struktally pili i penicillins, hiki i ka hana ke hana i ka nui o nā beta-lactamases i loaʻa i ka penicillin a me nā microorganism kūloko cephalosporin pale. Loaʻa i ka likika Clavulanic ka hopena o ka plasmid beta-lactamases, ka mea pinepine e hoʻoholo ai i ka kūʻē o nā maʻi, a ʻaʻole maikaʻi ia e kū'ē i ka chromosomal beta-lactamases type 1, ka mea i pale ʻole ʻia e ka clavulanic acid.

ʻO ka heleʻana o ka acid clavulanic i ka mākaukau o Augmentin e pale i ka amoxicillin mai ka luku ʻia e nā enzymes - beta-lactamases, kahi e hiki ai ke hoʻonui i ka maʻi antibacterial o amoxicillin.

Kahele

E like me ka hui pū ʻana o ka amoxicillin me ka clavulanic acid, ka paʻa ʻana o ka therapeutic o ka amoxicillin a me nā kūmole clavulanic i loaʻa i nā ʻano ʻāpana a me ka wai o ka interstitial (ma ke kīhole, ka palupalu o ka ʻōpū o ka ʻōpū, ka ʻili, ka adipose a me nā io o nā ʻiʻo, nā synovial a me ka peritoneal wai, ka ʻōpala, a me nā purulent. . ^ E Ha yM.

ʻO Amoxicillin a me clavulanic acid ka mea nāwaliwali ikaika i ka paʻa ʻana i nā protein plasma. Ua hōʻike nā noiʻi e pili ana i 25% o ka nui o ka nui clavulanic acid a me 18% o ka amoxicillin i loko o ke kō koko plasma e hoʻopili ai i nā protein plasma koko.

I nā haʻawina holoholona, ​​ʻaʻohe mea i hoʻohui ʻia o nā mea i hoʻomākaukau ʻia ai ka Augmentin® i kekahi mea ʻala. ʻO Amoxicillin, e like me ka hapa nui o nā penicillins, i hele i loko o ka waiū umauma. Hiki ke loaʻa hoʻi nā ʻōhua clavulanic acid i ka umauma umauma. Me ka ʻokoʻa o ka mea i hiki ai ke nānā ʻia, ʻehaʻī, a i ʻole ka candidiasis o nā membile mucous waha, ʻaʻohe hopena maikaʻi ʻole o ka amoxicillin a me ka clavulanic acid ma ke olakino o nā pēpē hānai keiki.

Ua hōʻike nā noiʻi holoholona holoholona i ka amoxicillin a me clavulanic acid e hoʻōla i ka paepae placental. Eia naʻe, ʻaʻohe mau hopena maikaʻi loa i ka wī.

Hāpai

ʻO 10-25% o ka pākuʻi mua o ka amoxicillin e hoʻopiʻi ʻia e nā keiki ma ke ʻano he metabolite ʻole ʻole (penicilloic acid). ʻO ka waikawa Clavulanic i hoʻohālikelike nui i ka 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-1 H-pyrrole-3-carboxylic acid a me 1-amino-4-hydroxybutan-2-hoʻokahi a hoʻopuka ʻia e nā keiki. ma o ka digestive tract, a me ka hau i pau i ke ano o ke hone.

E like me nā penicillins ʻē aʻe, ua hoʻohana nui ʻia ka amoxicillin e nā ʻōpū, aʻo ka clavulanic acid i ʻoki ʻia e nā pūniki a me nā hana pū.

Ma kahi o 60-70% o amoxicillin a ma kahi o 40-65% o ka clavulanic acid e hoʻopiʻi ʻia e nā keiki i loli ʻole i nā hola 6 i hala ma hope o ka hoʻomakeʻa ʻana o ka lāʻau. ʻO ka hoʻopili like o probenecid e hoʻolohi i ka hoʻopuka o ka amoxicillin, akā ʻaʻole ka clavulanic acid.

ʻLoe a me ke kākele

No ka lawelawe waha.

Hoʻonohonoho ka dosimen dosage i kū hoʻokahi i ka makahiki, ke kino, ke kaupaona ʻana o ka hana a ka mea maʻi, a me ka nui o ka maʻi. No ka hōʻemi i ka hikiʻole o gastrointestinal pīhoihoi a me ka hoʻoliʻi i ka hoʻopili ʻana, pono e lawe ʻia ka lāʻau i ka hoʻomaka o kahi pāʻina. ʻO ka papa haʻahaʻa o nā mea maʻi maʻiʻo 5 mau lā.

ʻAʻole pono e hoʻomau ka hoʻomehana no nā lā 14 me ka ʻole o ka loiloi o ke kūlana haukapila.

Inā pono, hiki ke hoʻokō i ka hana pae aʻoaʻo (neʻe mua, ke hoʻoponopono intravenous o ka mākaukau o Augmentin® ma ke ʻano hana; ʻoi ka pauku no ka hoʻomākaukau ʻana i kahi hopena no ka ʻoihana intravenous me ka hoʻololi hou ʻana i ka hoʻomākaukau o Augmentin® ma nā ʻano hana waha).

Pono e hoʻomanaʻo ʻia ʻo 2 mau papa o Augmentin® 250 mg + 125 mg ʻaʻole like i hoʻokahi papa o Augmentin® 500 mg + 125 mg.

Nā maʻi maʻi Hemodialysis

Hoʻoholo ʻia ka hoʻoponopono ʻia o ka Dosis ma ka lōʻihi loa o ke ʻano loiloi ʻo amoxicillin. 1 papa 500 mg + 125 mg i loko o hoʻokahi pahu i kēlā me kēia 24 hola

I ka manawa o ka dialysis, kahi hou 1 dosis (hoʻokahi papa) a me kekahi papa i ka hopena o ka hālāwai dialysis (e hoʻopiʻi i ka hoʻēmi ʻana i ka hoʻokaʻina o ka serum o ka amoxicillin a me ka clavulanic acid).

Kahawai

I nā haʻawina o ka hana reproduction i nā holoholona, ​​waha a me ka hoʻoponopono makua ʻo Augmentin® ʻaʻole i hopena i ka hopena teratogenic. I loko o kahi haʻawina hoʻokahi i nā wahine me ka pupule mua o ka membranes, ua ʻike ʻia ka pili o ka prophylactic drug therapy e pili ana i ka nui o ka pilikia o ka necrotizing enterocolitis i ka poʻe hānau hou. E like me nā lāʻau āpau, ʻaʻole loea ʻia ʻo Augmentin® no ka hoʻohana ʻana i ka wā hāpai, inā ʻaʻole ʻo ka pōmaikaʻi ka mea i manaʻo ʻia e ka ʻoi aʻe o ka maʻi hānai.

ʻ periodmeʻa

Hiki ke hoʻohana ʻia ka lāʻau lapaʻau Augmentin® i ka wā o ka umauma. Me ka ʻokoʻa ʻole o ka hiki ʻana o ka naʻau, ʻeha, a i ʻole ka candidiasis o nā membous mucous waha e pili ana me ka komo ʻana ʻana o nā wahi i loko o nā mea ikaika o kēia lāʻau lapaʻau i ka waiū umauma, ʻaʻohe mau hopena ʻē aʻe i ʻike ʻia i nā keiki hānai. I ka hopena o nā hopena maikaʻi loa i nā pēpē hānai keiki, pono e hoʻokaʻawale ka pale umauma.

Nā ʻōlelo kikoʻī

Ma mua o ka hoʻomaka ʻana i ka hoʻohana ʻana iā Augmentin, pono ka moʻolelo olakino e hōʻike i nā hanana hypersensitivity hiki i ka penicillin, cephalosporin a me nā mea like'ē aʻe.

Hiki i ka Augmentin Suspension ke pani i nā niho o ka mea maʻi. I mea e pale ʻole ai i ka hoʻomohala ʻana o ia hopena, ua lawa ia e nānā pono ana i nā lula mua o ka hoʻomaʻemaʻe waha - hoʻomaʻemaʻe i kou mau niho, e hoʻohana ana i nā rinses.

Ma muli o ka komo ʻana ʻo Augmentin e hoʻolilo i ka dizziness, no laila no ka lōʻihi o ke olakino e pale i ke kaʻa ʻana a hana i nā hana e pono ai ka nui o ka makaʻala.

ʻAʻole hiki ke hoʻohana ʻia ʻo Augmentin inā hiki ke nānā ʻia kahi ʻano infectious o ka mononucleosis.

Loaʻa i Augmentin ka hoʻohaʻahaʻa maikaʻi a me ka hoʻohaʻahaʻa haʻahaʻa. Inā koi ʻia ka hoʻohana ʻana i ka lāʻau lapaʻau, a laila pono ia e nānā pinepine i nā hana o nā pūpū a me ka ate.

Nosological ʻano papa (ICD-10)

1 I ka hana ʻana o ka lāʻau, hoʻokomo ʻia ka pā clavulanate me ka hapa nui o ka 5%.

Hoʻokuʻu ʻia ka wai hoʻomaʻemaʻe i ka wā o ka uhi ʻana i ka kiʻi ʻoniʻoni.

ʻO ka wehewehe ʻana i ke ʻano dosis

Kauoha: keʻokeʻo a ʻokoʻa paha keʻokeʻo, me kahi mea ʻalaʻawa. Ke hoʻokaʻawale ʻia, hana ʻia kahi laʻa ke keʻokeʻo a i ʻole keʻokeʻo paha. Ke kū, ke aniani nei a hoʻokeʻokeʻo paha ka pulu keʻokeʻo paha.

Nā Papaʻi, 250 mg + 125 mg: ua uhi ʻia me ka membrane kiʻiʻoniʻoni mai ke keʻokeʻo a kokoke i ke keʻokeʻo, ʻokoʻa ma ke ʻano, ma ke ʻano "AUGMENTIN" i hoʻokahi ʻaoʻao. Ma ka kink: mai ka papa melemele a hiki i keʻokeʻo.

Nā Pihi, 500 mg + 125 mg: ua uhi ʻia me kahi poʻokela kiʻi mai ke keʻokeʻo a hiki i ke keokeo i ka waihoʻoluʻu ʻulaʻula, me kahi ulana extruded "AC" a me ka weliweli ma kekahi ʻaoʻao.

Nā Kūlana, 875 mg + 125 mg: ua uhi ʻia me kahi poʻomanaʻo kiʻi mai ke keʻokeʻo a kokoke i ke keʻokeʻo, ʻokoʻa ma ke ʻano, me nā leka "A" a me "C" ma nā ʻaoʻao ʻelua a he laina hewa ma kekahi ʻaoʻao. Ma ka kink: mai ka papa melemele a hiki i keʻokeʻo.

Lapaʻau lāʻau

ʻO nā hua ʻelua e hāpai ana i ka hoʻomākaukau ʻana o ka Augmentin ® - amoxicillin a me ka acid clavulanic - e wikiwiki a holo a piha loa mai ke kumu o ka gastrointestinal ma hope o ka lawelawe waha. ʻO ka wehe ʻana o nā mea ikaika o ka lāʻau Augmentin ® ka mea maikaʻi loa i ka lawe ʻana i ka lāʻau lapaʻau i ka hoʻomaka ʻana o kahi pāʻina.

Ke hōʻike nei ka lāʻau lapaʻau pharmacokinetic o amoxicillin a me ka waikawa clavulanic i loaʻa i nā haʻawina like ʻole ma lalo nei, i ka wā i ʻike ʻia ai nā mea hana olakino maikaʻi ʻo 2-12 mau makahiki i ka ʻōpū hū ʻole 40 mg + 10 mg / kg / lā o ka lāʻau Augmentin ® i ʻekolu mauʻu, ka pauka no ka hoʻopiʻi waha. 125 mg + 31.25 mg i ka 5 ml (156.25 mg).

Nā lamaʻehā pharmacokinetic kumu

Amoxicillin

Augmentin ®, 125 mg + 31.25 mg ma 5 ml

Clavulanic waikawa

Augmentin ®, 125 mg + 31.25 mg ma 5 ml

Hōʻike ʻia ka lāʻau pharmacokinetic o ka amoxicillin a me ka waikawa clavulanic i loaʻa i nā haʻawina like ʻole ma lalo nei, i ka wā i hōʻike ʻia ai nā mea hana olakino ʻo 2-12 mau makahiki i ka ʻōpū ʻole e lawe ana iā Augmentin ®, ka pauka no ka hoʻokuʻu puki ʻana, 200 mg + 28.5 mg in 5 ml (228 , 5 mg) ma kahiʻu o 45 mg + 6.4 mg / kg / lā, ua māhele ʻia i ʻelua pota.

Nā lamaʻehā pharmacokinetic kumu

Ke hōʻike nei ka lāʻau lapaʻau pharmacokinetic o amoxicillin a me ka acid clavulanic i loaʻa i nā haʻawina like ʻole ma lalo nei, i ka manawa i lawe ai nā mea ola olakino i hoʻokahi dosis o Augmentin ®, ka pauka no ka pakanika waha, 400 mg + 57 mg ma 5 ml (457 mg).

Nā lamaʻehā pharmacokinetic kumu

ʻO nā hiʻohiʻona pharmacokinetic o amoxicillin a me ka acid clavulanic, i loaʻa i nā hoʻokolokolo like ʻole, i ka wā i lawe ai nā poʻe hana wikiwiki wikiwiki.

- 1 kōpū. Augmentin ®, 250 mg + 125 mg (375 mg),

- 2 mau papa Augmentin ®, 250 mg + 125 mg (375 mg),

- 1 kōpū. Augmentin ®, 500 mg + 125 mg (625 mg),

- 500 mg o amoexicillin,

- 125 mg o ka mana clavulanic.

Nā lamaʻehā pharmacokinetic kumu

Amoxicillin i ka hana o ka lāʻau Augmentin ®

Clavulanic waikawa i ka hoʻohui o ka lāʻau Augmentin ®

Ke hoʻohana nei i ka lāʻau lapaʻau Augmentin ®, nā like o ka plasma e pili ana i ka amoxicillin e like me ka poʻe me ka hoʻoponopono waha ma nā hopena like o amoxicillin.

ʻO nā hiʻohiʻona pharmacokinetic o amoxicillin a me ka clavulanic acid, i loaʻa i nā hana kaʻawale, i ka wā i lawe ai nā poʻe lawelawe wikiwiki.

- 2 mau papa Augmentin ®, 875 mg + 125 mg (1000 mg).

Nā lamaʻehā pharmacokinetic kumu

Amoxicillin i ka hana o ka lāʻau Augmentin ®

Augmentin ®, 875 mg + 125 mg

Clavulanic waikawa i ka hoʻohui o ka lāʻau Augmentin ®

Augmentin ®, 875 mg + 125 mg

E like me ka limahana ʻo ka hui ʻana o ka huixxillin me ka clavulanic acid, ka paʻa ʻana o ka therapeutic o ka amoxicillin a me ka clavulanic acid i loaʻa i nā ʻano kikoʻī a me nā interstitial fluid (ʻehā kūwaha, ʻōpū o ka ʻōpū, ka ʻili, ka momona a me ka ʻōpū mākia, nā synovial a me ka peritoneal flu, ka ʻili, ka hopena purulent. )

ʻO Amoxicillin a me clavulanic acid ka mea nāwaliwali ikaika i ka paʻa ʻana i nā protein plasma. Ua hōʻike nā noiʻi e pili ana i 25% o ka nui o ka nui clavulanic acid a me 18% o ka amoxicillin i loko o ke kō koko plasma e hoʻopili ai i nā protein plasma.

I nā haʻawina holoholona, ​​ʻaʻohe mea i hoʻohui ʻia o nā mea i hoʻomākaukau ʻia ai ka Augmentin ® i kekahi mea maʻi.

ʻO Amoxicillin, e like me ka hapa nui o nā penicillins, i hele i loko o ka waiū umauma. Hiki ke loaʻa hoʻi nā ʻōhua clavulanic acid i ka umauma umauma. Me ka ʻokoʻa ʻole o ka hoʻomohala ʻana i ka maʻi ʻaia a me ka candidiasis o nā membrane membous waha, ʻaʻohe mau hopena ʻē aʻe o ka amoxicillin a me ka clavulanic acid ma ke olakino o nā pēpē hānai hānai.

Ua hōʻike nā noiʻi holoholona holoholona i ka amoxicillin a me clavulanic acid e hoʻōla i ka paepae placental. Eia naʻe, ʻaʻohe mau hopena maikaʻi loa i ka wī.

10-25% o ka hoʻomaka mua o ka amoxicillin i hoʻopiʻi ʻia e nā keiki ma ke ʻano he metabolite ʻole ʻole (penicilloic acid). ʻO ka waikawa Clavulanic i hoʻohālikelike nui i ka 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-3H-pyrrole-3-carboxylic acid a me amino-4-hydroxy-butan-2-one a hoʻopili ʻia ma o nā ʻōpū Gastrointestinal tract, a me ka ea i pau i ke ano o ke kinikona.

E like me nā penicillins ʻē aʻe, ua hoʻohana nui ʻia ka amoxicillin e nā ʻōpū, aʻo ka clavulanic acid i ʻoki ʻia e nā pūniki a me nā hana pū.

Ma kahi o 60-70% o ka amoxicillin a ma kahi o 40-65% o ka clavulanic acid e hoʻopiʻi ʻia e nā keiki i loli ʻole i ka hana o 6 mau hola ma hope o ka lawe ʻana i ka papaʻaina. 250 mg + 125 mg a i ole 1 papa 500 mg + 125 mg.

ʻO ka hoʻopoloke i ka manawa like o probenecid e hoʻolohi i ka hoʻopuka o ka amoxicillin, akā ʻaʻole ka clavulanic acid (ʻike i ka "Interaction").

Nā ʻĀina Augmentin ®

Hoʻohui ʻia ka hui pū ʻana o ka amoxicillin me ka clavulanic acid no ka mālama ʻana i nā maʻi bacterial o nā wahi e pili ana i ka microorganism mahele i ka hui pū ʻana o ka amoxicillin me ka clavulanic acid:

nā maʻi ʻeha hanu luna kiʻekiʻe (komo pū me nā maʻi ENT), e.g. toniki ʻānōnē, sinusitis, otitis media, maʻamau maʻamau Streptococcus pneumoniae, Haemophilus influenzae 1, Moraxella catarrhalis 1 a me Streptococcus pyogenes, (koe wale nō i nā papa Augmentin 250 mg / 125 mg),

ʻōpū o ka hanu haʻahaʻa haʻahaʻa, e like me ka exacerbations o ke kaukau maʻa, bronch pneumonia, a me ka bronchopneumonia, i kumu pinepine ʻia Streptococcus pneumoniae, Haemophilus influenzae 1 a Moraxella catarrhalis 1,

ʻ infectionslelo pūpū pēpē, e like me ka cystitis, urethritis, pyelonephritis, maʻi ʻana o nā ʻōpū o ke ʻano wahine, ʻoi pinepine e nā ʻōiwi o ka ʻohana Enterobacteriaceae 1 (nui Escherichia coli 1 ), Staphylococcus saprophyticus a me nā ʻanoʻehā ʻO Kaukaʻāinapela nō hoʻi me ka gonorrhea i kumu e ka Neisseria kahakoli 1,

ʻeha a me nā ʻehaʻeha nā maʻi a me nā maʻi Staphylococcus aureus 1, Streptococcus pyogenes a me nā ʻanoʻehā Pauleʻa 1,

nā hopena o nā iwi a me nā ʻalā, e like me ka osteomyelitis, maʻamau i kumu Staphylococcus aureus 1, inā pono, hiki ke hoʻomalolo ka lōʻihi.

nā maʻi odontogenogen, no ka laʻana o ka periodontitis, sinusitis odontogen maxillary, heʻeha kaumaha kaumaha me ka hoʻolaha ʻana i ka cellulitis (wale nō no nā papa o Augmentin, nā dosages 500 mg / 125 mg, 875 mg / 125 mg),

Nā maʻi ʻē aʻe (no ka laʻana, ka haʻaleleʻana o septic, sepsis postpartum, sepsis intraabdominal) ma ke ʻano he lāʻau lapaʻau ʻana (wale nō no ka papa ʻaina Augmentin mau ʻano 250 mg / 125 mg, 500 mg / 125 mg, 875 mg / 125 mg),

ʻO nā mea kū hoʻokahi o nā ʻano microorganism i koho ʻia e hana i ka beta-lactamase, ka mea e hoʻonāukiuki iā lākou i ka amoxicillin (e nānā i ka Pharmacodynamics).

ʻO nā maʻi i hoʻomake ʻia e nā microorganisms i kūpono i ka amoxicillin e hiki ke mālama ʻia me Augmentin ®, no ka mea ʻo ʻAxinopillin kekahi o kāna mea hana. Hoike pū ʻia ʻo Augmentin ® no ka mālama ʻana i nā ʻili like ʻole i hoʻoiho ʻia e ka microorganisms i pili i ka amoxicillin, a me nā microorganism e hana ana i ka beta-lactamase, pili i ka hui ʻana o ka amoxicillin me ka clavulanic acid.

ʻO ka lili ʻana o nā maʻi i ka hui pū ʻana o ka amoxicillin me ka clavulanic acid e like me ka palena a me ka wā. Ma nā wahi e pono ai, e lawe pono ʻia nā ʻike ʻikepili kūloko. Inā pono, pono e hōʻiliʻili ʻia nā mea ʻike microbiological a hoʻopaʻa ʻia no ka naʻau bacteriological.

ʻŌpū a me ka lactation

I nā haʻawina o nā hana hoʻohālikelike i nā holoholona, ​​waha a me ka hoʻoponopono makua ʻo Augmentin ® ʻaʻole i hopena i ka hopena teratogenic.

I loko o kahi haʻawina hoʻokahi i nā wahine me ka pupule mua o nā membranes, ua ʻike ʻia ka pili o prophylactic therapy me Augmentin ® i pili i ka nui o ka pilikia o ka necrotizing enterocolitis i loko o nā keiki hou. E like me nā lāʻau āpau, ʻaʻole i kuhikuhi ʻia ka lāʻau Augmentin ® no ka hoʻohana ʻana i ka wā hapai, ke ʻole ke ʻāpono ʻia ka pōmaikaʻi o ka makuahine ma mua o ka hopena o ka wahine hāpai.

Hiki ke hoʻohana ʻia ka lāʻau lapaʻau Augmentin ® i ka wā o ka umauma. Me ka ʻokoʻa ʻole o ka hoʻomohala ʻana i nā maʻi pakanā a i ʻole kandidiasis o nā membous waha o ka waha waha i hoʻopili ʻia me ka komo ʻana o nā ʻina i nā mea ikaika o kēia lāʻau lapaʻau i ka waiū umauma, ʻaʻohe mau hopena ʻē aʻe i ʻike ʻia i nā keiki hānai hānai. I ka hopena o nā hopena maikaʻi loa i nā pēpē hānai keiki, pono e hoʻokaʻawale ka pale umauma.

Mea hana

ʻO SmithKlein Beach P.C. BN14 8QH, West Sussex, Vorsin, Clarendon Road, UK.

Ka inoa a me ka inoa o ka hui kū kānāwai e kau inoa ʻia ana ka palapala kākau inoa inoa: GlaxoSmithKline Trading CJSC. 119180, Moscow, Yakimanskaya nab., 2.

No ka ʻike hou aku, e hoʻopili: GlaxoSmithKline Trading CJSC. 121614, Moscow, st. Krylatskaya, 17, bldg. 3, papa 5. kahua kikowaena ʻoihana "Krylatsky."

Kelepona: (495) 777-89-00, fax: (495) 777-89-04.

ʻO Augmentin ® palena ka hopena

nā papa kiʻi ʻoniʻoni 250 mg + 125 mg 250 mg + 125 - 2 mau makahiki.

nā pani ʻoniʻoni kiʻi 500 mg + 125 mg - 3 mau makahiki.

nā papa kiʻi ʻoniʻoni 875 mg + 125 mg - 3 mau makahiki.

hoʻomoʻa no ka hoʻokuʻu ʻana aku no ka hoʻokūkū waha 125mg + 31.25mg / 5ml - 2 mau makahiki. ʻO ka pēpē i hoʻomākaukau ʻia he 7 lā.

pauku no ka hoʻōki ʻana no ka hoʻokūkū waha 200 mg + 28.5 mg / 5 ml 200 mg + 28.5 mg / 5 - 2 mau makahiki. ʻO ka pēpē i hoʻomākaukau ʻia he 7 lā.

pauku no ka hoʻōki ʻana no ka hoʻokūkū waha 400 mg + 57 mg / 5 ml 400 mg + 57 mg / 5 - 2 mau makahiki. ʻO ka pēpē i hoʻomākaukau ʻia he 7 lā.

Mai hoʻohana ma hope o ka lā pau pau i hōʻike ʻia ma ka pahu.