ʻO Glimecomb - nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana, nā loiloi, nā analogues a me nā puka i hoʻokuʻu ʻia (nā papa 40 mg 500 mg) o ka lāʻau lapaʻau no ka mālama ʻana i ka maʻi diabetes-2 like ʻole i ka pākeke, nā keiki a me ka hānau ʻana

I kēiaʻatikala, hiki iā ʻoe ke heluhelu i nā ʻōkuhi no ka hoʻohana ʻana i ka lāʻau lapaʻau Glimecomb. ^ E Ha yM. Hāʻawi i ka hoihoi mai ka poʻe kipa i ka pūnaewele - nā mea kūʻai o kēia lāʻau lapaʻau, me nā manaʻo o nā loea lapaʻau e pili ana i ka hoʻohana ʻana iā Glimecomb i kā lākou hoʻomaʻamaʻa. ʻO kahi noi nui, ʻo ia ke hoʻoikaika ikaika i kāu mau loiloi e pili ana i ka lāʻau lapaʻau: kōkua ka lāʻau lapaʻau a ʻaʻole hoʻi i kōkua i ka hoʻopiʻi ʻana i ka maʻi, nā mea hoʻopiʻi a me nā hopena ʻaoʻao, ua ʻike ʻia, ʻaʻole paha e hoʻolaha ʻia e ka mea hana ma ka palapala. ʻO Galogecomb analogues ma mua o nā mea i loaʻa i nā analogue hoʻokolohua. Hoʻohana no ka mālama ʻana i ka non-type type 2 like-insulin-makua i ka pākeke, nā keiki, a ma ka wā hāpai a me ka lactation. ʻO ka hui a me ka hoʻopili ʻana o ka lāʻau lapaʻau me ka waiʻona.

Glimecomb - hoʻohui i ka lāʻau hypoglycemic no ka hoʻohana waha. ʻO Glimecomb kahi hui paʻa o nā ʻaihue hypoglycemic waha o ka hui biguanide a me nā hui o ka sulfonylurea. Loaʻa iā ia ka hana pancreatic a me ka extrapancreatic hana.

ʻO Glyclazide (ʻo ka mea hana nui o ka lāʻau Glimecomb) kahi derogative sulfonylurea. Hoʻonui i ka mea huna o ka insulin e ka pancreas, hoʻonui i ka ʻike ʻana o nā ʻiʻo peripheral i insulin. Hoʻoweliweli ʻia ka hana o nā enzyme intracellular, e komo pū ana me ka synthetase glycogen. Hoʻihoʻi ia i ka mua o ka mea huna o ka mea huna o ka insulin, e hoʻēmi ana i ka manawa manawa mai ka manawa ʻai e ʻai ai i ka hoʻomaka ʻana o ka huna ʻana i ka insulin, a hoʻēmi ana i ka postprandial (ma hope o ka ʻai) hyperglycemia. Ma kahi o ka hoʻopiʻi ʻana i ka protein o ka hoʻoliʻi, hoʻāla ʻia ia i ka microcirculation, hoʻēmi i ka hoʻokeo o ka platelet a me ka hōʻuluʻulu ʻana, hoʻohemo i ka hoʻomohala ʻana o ka trombosis parietal, hoʻāliʻi i ka hanana o ka vascular a me ka pale ʻana i ka hoʻomohala ʻana o ka microthrombosis a me atherosclerosis, e hoʻihoʻi i ke kaʻina o ka physiet parietal fibrinolysis. Ke hoʻolōʻihi i ka hoʻomohala ʻana o ka retinopathy diabetes i ka papa non-proliferative, me ka maʻi nephropathy diabetes me ka hoʻohana lōʻihi, ʻike ʻia kahi emi nui i ka proteinuria. ʻAʻole ia e alakaʻi i ka hoʻonui nui o ke koʻikoʻi o ke kino, no ka mea i loaʻa ka hopena koʻikoʻi ma ka lihi o ka neʻe ʻana o ka huna ʻana i ka insulin a ʻaʻole i hoʻoulu ʻia i ka hyperinsulinemia, kōkua ia e hōʻemi i ke kaumaha o ke kino i nā mea maʻi obese, e whai ana i kahi meaʻai kūpono.

ʻO Metformin (ka lua o ka hana ikaika o ka lāʻau Glimecomb) pili i ka hui o biguanides. Hoʻemi ia i ka hoʻoliʻiliʻi o ka glucose i ke koko ma o ka lawe ʻana i ka gluconeogenesis i loko o ka ate, me ka hoʻohaʻahaʻa ʻana i ke kao o ka glucose mai ka gastrointestinal tract (GIT) a hoʻonui i kona hoʻohana ʻana i nā kiko. Hoʻemi i ka nānāʻana i ka serum o ke koko o ka triglycerides, cholesterol a me nā lipoproteins density haʻahaʻa (LDL), i hoʻoholo ʻia ma ka ʻōpū ʻole, a ʻaʻole e hoʻololi i ka neʻe ʻana o nā lipoproteins o kahi ʻokoʻa ʻē aʻe. Kōkua i ka hoʻokū ʻana a hōʻemi paha i ke kaupaona ʻana. I ka nele ʻana o ka insulin i loko o ke koko, ʻaʻole i hōʻike ʻia ka hopena therapeutic. ʻAʻole kūpono kahi hopena hypoglycemic. Hoʻonui i ka waiwai fibrinolytic o ke koko ma muli o ke kaohi ʻana o kahi inhibitor o ka profibrinolysin activator (plasminogen) kikoʻī.

Hōʻike

ʻO Glyclazide + Metformin + i mea hoihoi.

Lapaʻau lāʻau

Ma hope o ka lawelawe waha, ua kiʻekiʻe ke komo ʻana o ka gliclazide. ʻO ka pilina protein Plasma he 85-97%. Hoʻopili i ka puʻuwai. Hoʻokuʻu ʻia kēlā ma ke ʻano o nā metabolites e nā keiki - 70%, ma o nā ʻōpū - 12%.

Ma hope o ka lawelawe waha, ʻo ka loaʻa ʻana o ka metformin he 48-52%. Hoʻopili koke ʻia mai ka lolo. ʻO ka bioavailability piha (ma kahi ʻōpū ʻole) he 50-60%. Hoʻololi ka pilina ʻana no ka protein. Hiki i ka metformin ke hōʻuluʻulu i nā pona koko ʻula. Hoʻokuʻu ʻia ia e nā keiki, ka mea nui i ka loli ʻole (glomerular filtration and tubular secretion) a ma o ka peʻa (a hiki i 30%).

Nā Hōʻike

type 2 diabetes mellitus (non-insulin dependant) me ka hiki ʻole o ka mālama ʻana i ka lāʻau ʻaina, hoʻomaʻamaʻa a me ka mālama ʻana i ka mua me ka metformin a i ʻole gliclazide,
ka hoʻololi 'ana o ka hoʻololi mua ma mua o nā lāʻau lapaʻau (metformin a gliclazide) i nā mea maʻi me ka diabetes mellitus type 2 (non-insulin-dependant) me kahi paʻukūʻa mau me ka hala o ka nui o ka glucose.

E hoʻokuʻu i nā palapala

Nā Papa 40 mg + 500 mg.

Nā ʻōkuhi no ka hoʻohana a me ka regimen dosage

Lawe ʻia ka Glimecomb i ke wā ma mua a i ʻole ma hope o ka ʻaina. Hoʻoholo ʻia ka nui o ka lāʻau e ke kauka ponoʻī no kēlā me kēia maʻi, e pili ana i ke kiʻekiʻe o ka glucose koko.

ʻO ka maʻa mua ka mea maʻamau ʻo 1-3 papa i kēlā me kēia lā me kahi koho o ka waiʻae a hiki i kahi hoʻokō paʻa ʻana o ka maʻi. ʻO ka palena nui loa i kēlā me kēia lā he 5 papa.

Hoʻohana pinepine ʻia ka lāʻau lapaʻau i nā manawa 2 i ka lā (a kakahiaka a i ke ahiahi).

Loaʻa ka hopena

hypoglycemia (i ka hana hewa ʻana i ka hoʻoponopono nui ʻana a me ka ʻai ʻole) - ʻeha, hōʻeha, hopohopo, hoʻonui nui ʻia, nāwaliwali koʻikoʻi, palpitations, dizziness, nā mea hoʻonaninani kuikahi o nā neʻe, ka pilikia neurological ʻole,
me ka ulu ʻana o ka hypoglycemia, ka nalowale o ka hoʻopaʻa ʻana iā ʻoe iho, ka nalowale o ka ʻike,
lactic acidosis - nāwaliwali, myalgia, ʻeha hanu, nā kahe, ke ʻeha o ka ʻōpū, ka hōʻiliʻili ʻana o ka ʻōpū, hōʻemi i ke koko (BP), bradyarrhythmia,
dyspepsia - ke kala, ʻeha, ka ʻeha nui i loko o ka epigastrium, kahi ʻono "metallic" i loko o ka waha, pau ka momona,
hepatitis, jaundice cholestatic (hoʻihoʻi ʻia i ka lāʻau),
ka hana o ka transaminases hepatic, alkatine phosphatase (ALP),
ka pale ʻana i ka hematopoiesis o ka iwi - heemia, thrombocytopenia, leukopenia,
pruritus, urticaria, rash maculopapular,
ʻike maka
hememia anemia,
kūloko
ka hopena pili ʻana i ka ola me ka pohō a pau.

Nā Hoʻohui

ʻano hika type 1
maʻi maʻamau ketoacidosis,
diabetic precoma, diabetes coma,
huahuʻi,
pilikia hanalei,
nā hopenaʻeha e hiki ke alakaʻi i kahi loli i ka hana o ke keiki: kūʻai, maʻi hōʻeha, nā haʻalulu
nā maʻi ākea a paʻa paha i hele pū me ka hypoxia kiko: hiki i ka puʻuwai, ka hoʻopiʻi ʻana i ka maʻi, ke kuʻi ʻana o ka myocardial infarction, pīhoihoi,
pūpū hema
porphyria
hapai
lactation (umauma),
con conidone con miconazole,
mau kūlana e koi ai i ka ʻapiʻiwana insulin, e komo pū ai me nā maʻi hopuna, ka nui loa o ka hōʻino ʻana, nā mea hōʻeha, nā mea kuniahi.
humuho waiwa,
lilo i ka maʻi kūlohelohe,
lactic acidosis (me ka mōʻaukala o)
hoʻohana no ka liʻiliʻi he 48 mau hola ma mua a i loko o nā hola 48 ma hope o ka lawe ʻana i nā haʻawina radioisotope a i ʻole x-ray me ka hoʻomaka ʻana o ka iodine-medium vari,
ka adherence i ka meaʻai haʻahaʻa-emi (emi iho ma mua o 1000 mau kaleka i ka lā),
hypersensitivity i nā māhele o ka lāʻau lapaʻau,
hypersensitivity i nā derivatives sulfonylurea.

ʻŌpū a me ka lactation

Ua hoʻohana ʻia ka hoʻohana ʻana i ka lāʻau Glimecomb i ka wā hāpai. I ka wā e hoʻolālā ana i ka wā hāpai, ʻo ia hoʻi no ka wā hapai i ka wā lawe i ka lāʻau lapaʻau Glimecomb, pono e hoʻopau loa ia a e kuhikuhi ʻia ke ʻano o ka insulin.

ʻO Glimecomb contraindicated ma ka umauma, no ka mea, hiki ke hoʻopili ʻia nā mea ikaika i ka umauma umauma. I kēia hihia, pono ʻoe e hoʻololi i ka hoʻololi ʻana i ka insulin a i ʻole hoʻokū ʻaʻa.

Hoʻohana i nā keiki

Hoʻohana i nā mea maʻi maʻi

ʻAʻole ia e hoʻohana i ka lāʻau Glimecomb i nā mea maʻi i ʻoi aku ma mua o 60 mau makahiki e hana i ka hana kino kino, a pili pū me ka piʻi nui o ka lactic acidosis.

Nā ʻōlelo kikoʻī

Ke lawe wale nei ka hana Glimecomb me ka hoʻopili ʻana me ka mea haʻahaʻa haʻahaʻa, ʻo kaʻai haʻahaʻa. Pono e kiaʻi pinepine i ka pae glucose i loko o ke koko ma luna o ka ʻōpū ʻole a ma hope o ka ʻai ʻana, ʻoi aʻe hoʻi i nā lā mua o ka mālama ʻana me ka lāʻau lapaʻau.

Hiki ke kuhikuhi ʻia Glimecomb wale nō i nā mea maʻi e loaʻa mau ana i nā meaʻai maʻamau, pono iā ia ke komo i ka ʻaina kakahiaka a hāʻawi i ka hoʻopiʻi ʻana i nā haʻawaʻawa.

Ke kuhikuhi ʻana i ka lāʻau lapaʻau, pono e noʻonoʻo ʻia ma muli o ka komo ʻana o ka derivatives o ka sulfonylurea, hiki i ka hypoglycemia ke ulu, a i kekahi mau pilikia i kahi hana koʻikoʻi a lohi, e koi ana i ka hoʻokipa a me ka hoʻokele glucose i mau lā i kekahi mau lā. Hoʻokomo pinepine ka hypoglycemia me kahi meaʻai haʻahaʻa-haʻahaʻa, ma hope o ka hoʻolōʻihi ʻana a hoʻoikaika ikaika paha, ma hope o ka inu ʻana i ka wai ʻona, a i ʻole lawe ʻana i kekahi mau lāʻau hypoglycemic i ka manawa like. I mea e pale aku ai i ka hoʻomohala ʻana o ka hypoglycemia, pono ke nānā pono a me ka koho ʻana o kēlā me kēia dosis i ka maʻi, me ka hāʻawi ʻana i ka mea maʻi i ka ʻike holoʻokoʻa e pili ana i ka mālama ʻia. Me ka hoʻoulu ʻana o ke kino a me ke kaumaha, i ka wā e hoʻololi nei i ka meaʻai, pono ke hoʻoponopono ʻia o ka lāʻau lapaʻau Glimecomb.

Hoʻomaʻamaʻa koʻikoʻi i ka hana o nā lāʻau hypoglycemic he mau kānaka makua, nā mea maʻi e loaʻa ʻole i ka meaʻai kaulike, me kahi kūlana nāwaliwali nui, nā poʻe maʻi e loaʻa ana i ka maʻi o ka pituitary-adrenal.

Hiki i nā beta-blockers, clonidine, reserpine, guanethidine ke uhi i nā hōʻike kino o ka hypoglycemia.

Hoʻomaʻamaʻa ʻia nā mea maʻi e pili ana i ka hoʻonui nui o ka hypoglycemia i nā hihia lawe i ka ethanol (ka wai), nā lāʻau anti-inflammatory non-steroidal (NSAID), a me ka pōloli.

Me nā hōʻiliʻili nui a me nā hōʻeha, nā wela ākea, nā maʻi maʻi maʻi me ka febrile syndrome, pono pono e hoʻopau i nā lāʻau lapaʻaka hypoglycemic a kuhikuhi i ka lāʻau lapaʻau.

Ma ka lāʻau lapaʻau, pono ke nānā pono ʻana o ka hana. ʻO ka hoʻoholo ʻana o ka lactate ma ka plasma e lawe ʻia aku ma kahi o nā manawa 2 i ka makahiki, a me ke ʻano o ka myalgia. Me ka hoʻolālāʻana o ka acidosis lactic, e koi ʻia ai ka hoʻopau ʻana o ka mālama ʻana.

ʻO 48 mau hola ma mua o ke kaʻina hana a i ʻole hoʻokele intravenous o ka ʻenehana radiopaque iodine, e lawe ana iā Glimecomb e hoʻōki. Pono ke ʻano e hoʻomau ʻia ma hope o 48 mau hola.

E pale aku i ke ʻano o ka lāʻau me Glimecomb, pono e haʻalele ka mea maʻi i ka hoʻohana ʻana i ka waiʻona a me / a me nā meaʻawaʻawa etanol i loaʻa a me nā meaʻai.

Hoʻokomo i ka hiki ke lawe i nā kaʻa a kāohi i nā mīkini

I ka wā o ka mālama ʻana me Glimecomb, pono e mālama ʻia ka mālama ʻana i ka holo ʻana o nā kaʻa a i ke komo ʻana i nā hana ʻē aʻe ʻē aʻe e koi ai i ka piʻi nui o ka nānā a me ka wikiwiki o ka hopena psychomotor.

Hoʻohui nūhou

Ke hoʻoikaika nei i ka hopena hypoglycemic o ka lālani Glimecomb i nānā ʻia me ka hoʻohana pū ʻana me ka angiotensin-hoʻololi i nā enzyme (ACE) inhibitors (captopril, enalapril), histamine H2-receptor blockers (cimetidine), nā lāʻau antifungal (miconazole, fluconazole), NSAIDs, fenobenzene, azonenena (clofibrate, bezafibrat), nā lāʻau anti-TB (ethionamide), salicylates, Coumarin anticoagulants, anabolic steroid, beta-blockers, monoa inhibitors inoxidase (MAO), sulfonamides lōʻihi lōʻihi, me ka cyclophosphamide, chloramphenicol, fenfluramine, fluoxetine, guanethidine, pentoxifylline, tetracycline, theophylline, tubular secretion blockers, reserpine, bromocriptine, disopyramide, pyrimidamide, pyrimidamide insulin), allopurinol, oxytetracycline.

ʻO ka hoʻohaʻahaʻa i ka hopena hypoglycemic o ka lāʻau Glimecomb e nānā me ka hoʻohana pū ʻana me ka barbiturates, glucocorticosteroids (GCS), agonists adrenergic (epinephrine, clonidine), nā lāʻau antiepileptic (phenytoin), me ka pale ʻana o nā hāmeʻa hāmama, amia atomide amide aideide asparaginase, me ka baclofen, danazole, diazoxide, isoniazid, me ka morphine, rhytodrine, salbutamol, terbutaline, me glucagon, rifampicin, me g rmonami thyroid, likiuma paʻakai, me ka kiʻekiʻe nā māhele o nicotinicʻakika, chlorpromazine, ku una contraceptives a me estrogens.

Hoʻonui i ka ikehu o ka ventricular extrasystole ma ke kua o ka glycosides cardiac.

ʻO nā lāʻau lapaʻau e pale i ka hematopoiesis pumehana o ka iwi e hoʻonui i ka hopena o ka myelosuppression.

Hoʻonui ka Ethanol (wai) i ka hopena o ka lactic acidosis.

Hoʻopau ka Metformin i ka nui o ke kaila o ka plasma a me ka hapalua o ke ola o ka furosemide e 31 a me 42.3%, kekona.

Hoʻonui ka Furosemide i ka nui o ka piʻiʻana o ka metformin e 22%.

Hoʻonui ka Nifedipine i ka hoʻopili ʻana, hoʻolohi i ka hoʻopuka o nā metformin.

ʻO ka lāʻau lapaʻau Cationic (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren a me vancomycin) i hūnā ʻia i loko o nā ʻōpū e hoʻohālikelike ana i nā ʻōnaehana o ka tubular a, me ka hoʻomanawanui lōʻihi, hiki ke hoʻonui i ka kaomi nui o ka metformin i loko o ke koko koko e 60%.

Nā inoa o ka lāʻau Glimecomb

ʻAʻole i loaʻa i ka Glimecomb nā kikowaena hoʻolālā no ke ʻano ikaika.

ʻO nā ʻōmaka no ka hopena therapeutic (nā lāʻau lapaʻau no ka mālamaʻana i ka maʻi mellitus non-insulin-hilinaʻi):

Avandamet
Avandia
Adebite
Amaril
Anvistat
Antidiab
Arfazetin,
Bagometua,
Betanase
Biosulin P,
Vazoton
Victoza
Vipidia,
Galvus
Glemaz
Hoʻolālā
Glibenezera
Glibomet,
Holaʻula
Hopu,
Kauwe,
Daonil
Diabeton
Diastabol,
Dibikor
Insulin s
Listata
Metfogamma,
Metformin
Mikstard Penfill,
Monotard MC,
Neovitel
NovoMix Penfill,
Noliprel A
Orsoten
ʻO Pankragen,
Penulin
ʻĀina Pioglar
Prediania
Presartan,
Hoʻololi
Saxenda
Kaule Haul,
Siofor
Starlix
Telzap
Nā Telsartan
Tricor
Formin
Chitosan
Chlorpropamide
Humalog
Humulin
Cigapan
Endur-B,
Erbisol
Euglucon,
Hoavius
ʻO Yanumet Long.

He manaʻo o Endocrinologist

ʻO Glimecomb ka lāʻau antidiabetic kahi papa inoa pōkole o nā hōʻailona a me kahi ākea ākea ākea. No laila, ʻaʻole pono e koho pinepine. Nā maʻi i kēlā me kēia maʻi me ka maʻi diabetes mellitus type 2 i koho iaʻu iho. I ka poʻe maʻi e nānā pono ana i nā lula o ka lawe ʻana iā Glimecomb, ulu pinepine ka hopena i ka hanana ma mua o nā mea maʻi e kū ʻole nei i nā ʻōlelo aʻoaʻo. ʻO nā ʻeha o ka hypoglycemia koʻikoʻi me ka nalowale o ka ʻike ma mua o koʻu mau hana i ka wā e lawe ʻia ai nā maʻi ma ka haukapila. Akā i ka laulā nui, hiki iaʻu ke ʻōlelo i ke kūpaʻa ka lāʻau lapaʻau e nā maʻi.

Nā hōʻailona no ka hoʻohana ʻana

- ke ʻano type 2 diabetes mellitus (ka non-insulin-dependant) me ka hoʻopiʻi ʻole ʻana o ka ʻaʻai meaʻai, hoʻomaʻamaʻa a me ka mālama ʻana me ka metformin a i ʻole gliclazide,

- ka pana o ka lāʻau o mua me nā lāʻau ʻelua (metformin a gliclazide) i nā mea maʻi me ka maʻi diabetes mellitus type 2 (non-insulin-dependence) me kahi kaila paʻa kūloko a paʻa pono.

Nā Hoʻohui

- ka momo 1 diabetes mellitus (kūlike i ka insulin),

- pilikia hania

- nā maʻi koʻikoʻi e hiki ke alakaʻi i kahi loli i ka hana o ka hana: i kahi o ka maʻi, maʻi hōʻeha, ke kū

- nā maʻi a me ka maʻi paha e hele pū me ka hypoxia kiko: hiki ʻole i ka naʻau, ka hoʻopiʻi ʻana o ka ea, ka infarction myocardial hou loa

- lactation (umauma),

- nā kūlana e koi ai i ka ʻapiʻema insulin, ʻo ia hoʻi ʻeha nā maʻi maʻi loa, nā hōʻiliʻili nui, nā mea hōʻeha, nā mea kuni ʻana.

- ulana pōpilikia

- ka acidosis lactic (me ka mōʻaukala),

- hoʻohana no ka liʻiliʻi he 48 mau hola ma mua a i loko o nā hola 48 ma hope o ka hoʻopaʻa ʻana i nā haʻawina radioisotope a i ʻole X-ray me ka hoʻomaka ʻana o ka iodine-medium medium,

- ka mālamaʻana i kahi pāʻina haʻahaʻa-haʻahaʻa (emi iho ma mua o 1000 cal / lā),

- Kūpono o ka'āpana o ka lāʻau,

- Hypersensitivity i nā derivatives sulfonylurea ʻē aʻe.

Pehea e hoʻohana ai: dosis a me ke ʻano o ka mālama ʻana

Lawe ʻia ka lāʻau ma mua a ma hope koke iho o ka ʻai ʻana. Hoʻoholo ʻia ka nui o ka lāʻau e ke kauka ponoʻī no kēlā me kēia maʻi, e pili ana i ke kiʻekiʻe o ka glucose koko.

ʻO 1-3 ka papa ma mua he 1-3 papa / lā me kahi koho o ka maʻi a hiki i ka loaʻa ʻana o kahi uku mau o ka maʻi. ʻO ka palena nui loa i kēlā me kēia lā he 5 papa.

Hoʻohana pinepine ʻia ka lāʻau lapaʻau i nā manawa 2 / lā (kakahiaka a i ke ahiahi).

Nā hopena hopena

Mai ka pūnaehana endocrine: hypoglycemia (i ka hana hewa ʻana o ka dimen regdate a me ka ʻai ʻole) - hōʻeha ka ʻeha, ke kaumaha, ka pōloli, ka nui ʻana o ka luhi, nā nāwaliwali nui, palpitations, dizziness, ka hoʻonohonoho ʻana o nā neʻe, ka pilikia o ka wā neʻe, a me ka holomua o ka hypoglycemia, ka hala ʻana o ka pale ʻana, nalowale o ka ike ana.

Mai ka ʻaoʻao o ka metabolism: i kekahi mau hihia - ka lactic acidosis (nāwaliwali, myalgia, ʻeha hanu, nā kahe, ʻeha o ka ʻōpū, hipotermia, hoʻoemi i ke koko, bradyarrhythmia).

Mai ka pūnaehana ʻana: dyspepsia (ʻeha, ʻeha, ka ʻeha kaumaha i loko o ka epigastrium, kahi ʻatikala "metallic" i loko o ka waha), i ka hōʻemi ʻana i ka makemake (me ka palu o kēia mau ʻano i ka ʻai me ka ʻai ʻana), ka maʻi hepatitis, jaundice cholestatic (lawe ʻia ka lāʻau) , nā hana i hoʻonui ʻia o ka transaminases hepatic, phosphatase alkaline.

Mai ka ʻōnaehana hemopoietic: līkuhi - kaohi ʻana o ka hematopoiesis sumsum lua o ka iwi (anemia, thrombocytopenia, leukopenia).

He maʻi kūlohelohe: itching, urticaria, maculopapular rash.

ʻO nā mea'ē aʻe: ʻike maka.

Nā ʻōlelo kikoʻī

Hiki ke kuhikuhi ʻia Glimecomb wale nō i nā mea maʻi e loaʻa mau ana i nā meaʻai maʻamau, pono iā ia ke komo i ka ʻaina kakahiaka a hāʻawi i ka hoʻopiʻi ʻana i nā haʻawaʻawa.

Hoʻohui

Ke hoʻoikaika nei i ka hopena hypoglycemic o ka lālia Glimecomb i nānā ʻia me ka hoʻohana pū ʻana me ACE inhibitors (captopril, enalapril), histamine H2-receptor blockers (cimetidine), nā lāʻau antifungal (miconazole, fluconazole), NSAIDs (phenylbutazone, azapropenbibazate ), nā lāʻau lapaʻau anti-TB (ethionamide), salicylates, Coumarin anticoagulants, anabolic steroid, beta-blockers, MAO inhibitors, long-acting sulfonamides , me ka cyclophosphamide, chloramphenicol, fenfluramine, fluoxetine, guanethidine, pentoxifylline, tetracycline, theophylline, tubular secretion blockers, reserpine, bromocriptine, disopyramide, pyridoxine, a me nā lāʻau ʻokoʻa e like me ke ʻano o ka hypoglycemic, t. . ^ E Ha yM.

ʻO ka hoʻēmi ʻana i ka hopena hypoglycemic o ka lāʻau Glimecomb e nānā me ka hoʻohana pū ʻana me ka barbiturates, GCS, agonists adrenergic (epinephrine, clonidine), nā lāʻau antiepileptic (phenytoin), me nā wahi neʻe o ka lālani kaleponi, nā mākaʻōmaika o ka hāmeʻomaika, acetazolamide di-amide diide-diide amideet me ka baclofen, danazole, diazoxide, isoniazid, me ka morphine, ritodrin, salbutamol, terbutaline, me glucagon, rifampicin, me nā hormone thyroid s, ka paʻakai lithium, me nā koina kiʻekiʻe o ka waikawa nicotinic, chlorpromazine, waha i ka pehu a me nā estrogens.

Hoʻonui i ka ikehu o ka ventricular extrasystole ma ke kua o ka glycosides cardiac.

ʻO nā lāʻau lapaʻau e pale i ka hematopoiesis pumehana o ka iwi e hoʻonui i ka hopena o ka myelosuppression.

Hoʻonui ka Ethanol i ka nui o ka acidact lactic.

Nā nīnau, nā pane, nā loiloi o ka lāʻau Glimecomb

ʻO ka ʻikepili i hāʻawi ʻia e hana no nā lāʻau lapaʻau a me nā lāʻau lapaʻau. Aia nā ʻike e pili ana i ka lāʻau lapaʻau e pili ana i nā ʻōlelo i hoʻopili ʻia e ka mea hoʻopiʻi e ka mea hana. ʻAʻohe ʻikepili i hoʻopili ʻia ma kēia a ʻole kekahi ʻaoʻao o ka pūnaewele a mākou e hiki ke lawelawe ma kahi kūʻokoʻa no ka hoʻopiʻi pilikino i ka loea.

Manawa kuhikuhi

Ka mea nona ka palapala hoʻopaʻa inoa: Chemical and Pharmaceutical Combine Akrikhin, OJSC (Russia)
Hōʻike: Akrikhin OJSC (Rūsia)

E hoʻokuʻu i ke ʻano
Nā ʻōpala 40 mg + 500 mg: 60 mau kekona.

Hoʻohui ʻia nā lāʻau hypoglycemic no ka hoʻohana waha. ʻO Glimecomb® ka hui pūpū o ʻelua mau lawelawe hypoglycemic waha o ka hui biguanide a me ka hui sulfonylurea.

Loaʻa iā ia ka hana pancreatic a me ka extrapancreatic hana.

ʻO Glyclazide kahi derobe o ka sulfonylurea. Hoʻonui i ka mea huna o ka insulin e ka pancreas, hoʻonui i ka ʻike ʻana o nā ʻiʻo peripheral i insulin. Hoʻowalewale i ka hana o nā kinipili intracellular - kūlohelohe glycogen synthetase. Hoʻihoʻi hou ia i ka mua o ka mea huna o ka mea huna o ka insulin, e hoʻēmi ana i ka manawa manawa mai ka manawa ʻai e ʻai ai i ka hoʻomaka ʻana o ka huna ʻana i ka insulin, a hoʻēmi ana i ka hyperglycemia postprandial. Ma kahi o ka hoʻopiʻi ʻana i ka protein o ka hoʻoliʻi, hoʻāla ʻia ia i ka microcirculation, hoʻēmi i ka hoʻokeo o ka platelet a me ka hōʻuluʻulu ʻana, hoʻohemo i ka hoʻomohala ʻana o ka trombosis parietal, hoʻāliʻi i ka hanana o ka vascular a me ka pale ʻana i ka hoʻomohala ʻana o ka microthrombosis a me atherosclerosis, e hoʻihoʻi i ke kaʻina o ka physiet parietal fibrinolysis. Ke hoʻolōʻihi i ka hoʻomohala ʻana o ka retinopathy diabetes i ka papa non-proliferative, me ka maʻi nephropathy diabetes me ka hoʻohana lōʻihi, ʻike ʻia kahi emi nui i ka proteinuria. ʻAʻole ia e alakaʻi i ka hoʻonui nui o ke kaumaha kino, no ka mea aia kahi hopena nui ma ka wana o ka neʻe o ka huna ʻana o ka insulin a ʻaʻole ia i hoʻoulu i ka hyperinsulinemia, ke kōkua i ka hoʻemi ʻana o ke kaumaha o ke kino i ka mea hoʻomoea o ka lālani, ma ke ʻano o kahi meaʻai kūpono.

Aia ʻo Metformin i ka hui o nā biguanides. Hoʻemi ia i ka hoʻoliʻiliʻi o ka glucose i ke koko ma ka hoʻokaʻawale ʻana i ka gluconeogenesis i loko o ka ate, e hoʻemi ana i ka komo ʻana o ka glucose mai ka digestive tract a hoʻonui i ka hoʻohana ʻana i nā ʻōnaehana. Hoʻemi i ka paneʻana o ka triglycerides, cholesterol a me LDL (i hoʻoholo ʻia i kahi ʻōpū ʻole) i ka serum o ke koko a ʻaʻole hoʻololi i ka paʻa o nā lipoproteins o kahi kūʻokoʻa ʻē aʻe. Kōkua i ka hoʻokū ʻana a hōʻemi paha i ke kaupaona ʻana. I ka nele ʻana o ka insulin i loko o ke koko, ʻaʻole i hōʻike ʻia ka hopena therapeutic. ʻAʻole kūpono kahi hopena hypoglycemic. Hoʻonui i ka waiwai fibrinolytic o ke koko ma muli o ke kaohi ʻana o kahi inhibitor o ka profibrinolysin activator (plasminogen) kikoʻī.

Hoʻomoe a me ka hoʻolele

Ma hope o ka lawelawe waha, ua kiʻekiʻe ke komo ʻana. I ka wā e lawe ai i ka pākaukau o 40 mg C max i loko o ke kaila koko a hōʻea ma hope o 2-3 mau hola a lilo i 2-3 μg / ml. ʻO ka pilina protein Plasma he 85-97%.

Metabolism a me ka hoʻopā ʻana

Hoʻopili i ka puʻuwai. T 1/2 - mau hola 8-20. ʻO ia ka mea i hoʻopuka nui ʻia ma nā ʻano o nā metabolites e nā keiki - 70%, ma o nā ʻōpū - 12%.

I ka poʻe maʻi nā maʻi, ʻaʻole i ʻike ʻia nā loli nui i loko o nā laikini pharmacokinetic.

Hoʻomoe a me ka hoʻolele

Ma hope o ka lawelawe waha, ʻo 48-52% ka lilo ʻana. Hoʻopili koke ʻia mai ka lolo. ʻO ka bioavailability piha (ma kahi ʻōpū ʻole) he 50-60%. Loaʻa ka C max i ka plasma koko ma hope o 1.81-2.69 h a ʻaʻole iʻoi aku i ka 1 1g / ml. ʻO ka haʻahaʻa me ka meaʻai e hōʻemi ana i ka C max i ka plasma ma 40% a me ka hoʻolalelale ʻana i kāna loaʻa ʻana e 35 mau minuke. Hoʻololi ka pilina ʻana no ka protein. Hiki i ka metformin ke hōʻuluʻulu i nā pona koko ʻula.

ʻO T 1/2 mau hola 6.2, ua hoʻihoʻi ʻia e nā keiki, ka hapanui o ka loli (glomerular filtration a me ka tubular secretion) a ma o nā ʻāpana (a hiki i 30%).

- ke ʻano type 2 diabetes mellitus (ka non-insulin-dependant) me ka hoʻopiʻi ʻole ʻana o ka ʻaʻai meaʻai, hoʻomaʻamaʻa a me ka mālama ʻana me ka metformin a i ʻole gliclazide,

- ka pana o ka lāʻau o mua me nā lāʻau ʻelua (metformin a gliclazide) i nā mea maʻi me ka maʻi diabetes mellitus type 2 (non-insulin-dependence) me kahi kaila paʻa kūloko a paʻa pono.

Lawe ʻia ka lāʻau ma mua a ma hope koke iho o ka ʻai ʻana. Hoʻoholo ʻia ka nui o ka lāʻau e ke kauka ponoʻī no kēlā me kēia maʻi, e pili ana i ke kiʻekiʻe o ka glucose koko.

ʻO 1-3 ka papa ma mua he 1-3 papa / lā me kahi koho o ka maʻi a hiki i ka loaʻa ʻana o kahi uku mau o ka maʻi. ʻO ka palena nui loa i kēlā me kēia lā he 5 papa.

Hoʻohana pinepine ʻia ka lāʻau lapaʻau i nā manawa 2 / lā (kakahiaka a i ke ahiahi).

Mai ka ʻaoʻao o ka metabolism: i kekahi mau hihia - ka lactic acidosis (nāwaliwali, myalgia, ʻeha hanu, nā kahe, ʻeha o ka ʻōpū, hipotermia, hoʻoemi i ke koko, bradyarrhythmia).

Mai ka ʻōnaehana hemopoietic: līkuhi - kaohi ʻana o ka hematopoiesis sumsum lua o ka iwi (anemia, thrombocytopenia, leukopenia).

He maʻi kūlohelohe: itching, urticaria, maculopapular rash.

ʻO nā mea'ē aʻe: ʻike maka.

I ka hihia o nā hopena kaulike, e hoʻemi ʻia ka nui o ka lāʻau a i ʻole ke hōʻola ʻokoʻa.

ʻO nā hopena maʻamau o nā derivatives o ka sulfonylurea: erythropenia, agranulocytosis, anemia hemolytic, pancytopenia, vasculitis alerine, hoʻoweliweli ma ka hopena o ke ola.

- ka momo 1 diabetes mellitus (hilinaʻi-kū i ka insulin),

- nā maʻi precoma, maʻi koma maʻi,

- pilikia hania

- nā maʻi koʻikoʻi e hiki ke alakaʻi i kahi loli i ka hana o ka hana: i kahi o ka maʻi, maʻi hōʻeha, ke kū

- nā maʻi a me ka maʻi paha e hele pū me ka hypoxia kiko: hiki ʻole i ka naʻau, ka hoʻopiʻi ʻana o ka ea, ka infarction myocardial hou loa

- lactation (umauma),

- ka hui pūʻana o ka miconazole,

- nā kūlana e koi ai i ka ʻapiʻema insulin, e komo pū ai ʻeha nā maʻi maʻi loa, nā hōʻiliʻili nui, nā mea hōʻeha, nā mea kuni ʻana.

- ulana pōpilikia

- ka acidosis lactic (me ka mōʻaukala),

- hoʻohana no ka liʻiliʻi he 48 mau hola ma mua a i loko o nā hola 48 ma hope o ka hoʻopaʻa ʻana i nā haʻawina radioisotope a i ʻole X-ray me ka hoʻomaka ʻana o nā iodine e ʻike ʻia ana nā ʻano mea ʻē aʻe.

- ka mālamaʻana i kahi pāʻina haʻahaʻa-haʻahaʻa (emi iho ma mua o 1000 cal / lā),

- Kūpono o ka'āpana o ka lāʻau,

- Hypersensitivity i nā derivatives sulfonylurea ʻē aʻe.

ʻAʻole ia e hoʻohana i ka lāʻau lapaʻau i nā mea maʻi ma mua o 60 mau makahiki e hana i ka hana kino kino, a pili pū me ka piʻi nui o ka lactic acidosis.

Me ka mālama aka, pono e hoʻohana ʻia ka lāʻau i ka hihia o ka febrile syndrome, ka adrenal insufficiency, hypofunction o ka anterior pituitary, nā maʻi o ka nui o ka lolo thyroid me ka hana ʻole.

Ua hoʻohana ʻia ka hoʻohana ʻana i ka lāʻau Glimecomb ® i ka wā hāpai. I ka wā e hoʻolālā ana i ka wā hāpai, ʻo ia hoʻi no ka wā hapai i ka manawa o ka lawe ʻana i ka lāʻau lapaʻau Glimecomb ®, pono e hoʻopau loa ia a e kuhikuhi ʻia nō ka lāʻau lapaʻau.

ʻO Glimecomb ® ka contraindicated ma ka umauma, ʻo ka mea hiki ke hoʻopili ʻia nā mea ikaika i ka waiū umauma. I kēia hihia, pono ʻoe e hoʻololi i ka hoʻololi ʻana i ka insulin a i ʻole hoʻokū ʻaʻa.

Nā hōʻailona: hiki ke lactic acidosis (no ka mea he metformin he ʻāpana o ka lāʻau), hypoglycemia.

Hoʻohana: i ka wā e ʻike ʻia ai nā hōʻailona o ka acidosis lactic, pono ʻoe e hoʻōki i ka lawe ʻana i ka lāʻau. Lactic acidosis kahi kūlana e koi ai i ka mālama mālama olakino, mālama ʻia ka lāʻau lapaʻau i loko o ka haukapila. ʻO ka hopena kūpono e pili ana i ka hemodialysis.

Me ka hypoglycemia maʻalahi a hōʻoluʻolu paha, ua lawe ʻia ka glucose (dextrose) a i ʻole ka loaʻa honi. Ma ka hihia o ka hypoglycemia koʻikoʻi (ka nalowale o ka ʻike) ʻole, kahi hopena o 40% dextrose (glucose) a i ʻole iv glucagon, i / m a i ʻole / s e lawelawe ʻia iv. Ma hope o ka hāpai hou ʻana, pono e hāʻawi ka mea maʻi i nā meaʻai momona-momona e pale ai i ka hoʻomohala hou ʻana o ka hypoglycemia.

Ke hoʻoikaika nei i ka hopena hypoglycemic o ka lālani Glimecomb ® i nānā ʻia me ka hoʻohana pū ʻana me ACE inhibitors (captopril, enalapril), histamine H 2 blockor blockers (cimetidine), nā lāʻau antifungal (miconazole, fluconazole), NSAIDs (phenylbutazone, oxapropibone, azapropibone) , bezafibrat), nā lāʻau lapaʻau anti-TB (ethionamide), salicylates, Coumarin anticoagulants, anabolic steroid, beta-blockers, MAO inhibitors, long-acting sulfonamides vii, me ka cyclophosphamide, chloramphenicol, fenfluramine, fluoxetine, guanethidine, pentoxifylline, tetracycline, theophylline, tubular secretion blockers, reserpine, bromocriptine, disopyramide, pyridoxine, a me nā lāʻau maʻi hypoglycemic ʻē aʻe, luanuhauna.

ʻO ka hoʻēmi ʻana i ka hopena hypoglycemic o ka lālani Glimecomb ® e nānā me ka hoʻohana pū ʻana me ka barbiturates, GCS, agonists adrenergic (epinephrine, clonidine), nā lāʻau antiepileptic (phenytoin), me nā wahi neʻe o ka lālani kalepona, nā kaila o ka hoʻoneʻisepelika, acetyl azidemide diuretics , me baclofen, danazole, diazoxide, isoniazid, me morphine, ritodrin, salbutamol, terbutaline, me glucagon, rifampicin, me nā hormone thyroid zy, likiuma paʻakai, me ka kiʻekiʻe nā māhele o nicotinicʻakika, chlorpromazine, ku una contraceptives a me estrogens.

Hoʻonui i ka ikehu o ka ventricular extrasystole ma ke kua o ka glycosides cardiac.

ʻO nā lāʻau lapaʻau e pale i ka hematopoiesis pumehana o ka iwi e hoʻonui i ka hopena o ka myelosuppression.

Hoʻonui ka Ethanol i ka nui o ka acidact lactic.

Hoʻokuʻu ka Metformin i ka C max i ka plasma a me ka T 1/2 o ka furosemide e 31 a me 42.3%, kekahi.

Hoʻonui ka Furosemide iā C max metformin e 22%.

Hoʻonui ka Nifedipine i ka hoʻopili ʻana, hoʻonui iā C max i ka plasma koko, a me ka hoʻolohi ʻana i nā mea o ke metformin.

ʻO ka lāʻau lapaʻau Cationic (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren a me vancomycin) i hūnā ʻia i loko o nā pākaukau e hoʻokūkū ana no nā ʻōnaehana o ka tubular a, me ka hoʻomanawanui lōʻihi, hiki ke hoʻonui iā C max metformin i ka punela koko ma o 60%.

Contraindicated i ka hāʻule ʻole o ka ate.

Contraindicated i ka pilikia hanehae koʻikoʻi, nā maʻi kūpono e hiki ai ke alakaʻi i kahi loli i nā hana ʻoi: dehydration, maʻiʻino, weliweli.

Ke lawe pū nei ka lāʻau me Glimecomb ® i ka hoʻohui pū me ka mea haʻahaʻa haʻahaʻa, ʻo kaʻai haʻahaʻa. Pono e kiaʻi pinepine i ka pae glucose i loko o ke koko ma luna o ka ʻōpū ʻole a ma hope o ka ʻai ʻana, ʻoi aʻe hoʻi i nā lā mua o ka mālama ʻana me ka lāʻau lapaʻau.

Hiki ke kau ʻia ke Glimecomb ® i nā mea maʻi e loaʻa mau ana i nā meaʻai maʻamau, pono iā ia ke komo i ka ʻaina kakahiaka a hāʻawi i ka hoʻopiʻi ʻana i nā haʻawaʻawa.

Hiki i nā beta-blockers, clonidine, reserpine, guanethidine ke uhi i nā hōʻike kino o ka hypoglycemia.

Hoʻomaʻamaʻa ʻia nā mea maʻi e pili ana i ka hoʻonui nui o ka hypoglycemia i nā hihia o ka ethanol, NSAID, a me ka pōloli.

Me nā hōʻiliʻili nui a me nā hōʻeha, nā wela ākea, nā maʻi maʻi maʻi me ka febrile syndrome, pono pono e hoʻopau i nā lāʻau lapaʻaka hypoglycemic a kuhikuhi i ka lāʻau lapaʻau.

He 48 mau hola ma mua o ka hoʻokō ʻana a i ʻole / i loko o ka hoʻopuka ʻana aku o ka ʻāpana radiopaque iodine, e hoʻopau ʻia ka lāʻau lapaʻau Glimecomb ®. Pono ke ʻano e hoʻomau ʻia ma hope o 48 mau hola.

E pale aku i ke ʻano o ka lāʻau me Glimecomb ®, pono e haʻalele ka mea maʻi i ka hoʻohana ʻana i ka waiʻona a me / a me nā meaʻawaʻawa etanol i loaʻa a me nā meaʻai.

Hoʻokomo i ka hiki ke lawe i nā kaʻa a kāohi i nā mīkini

I ka wā o ka mālama ʻana, pono e mālama ʻia i ka wā e alakaʻi ana i nā kaʻa a komo i nā hana ʻē aʻe ʻē aʻe e koi ai i ka nui o ka neʻe ʻana a me ka wikiwiki o ka hopena psychomotor.

E hoʻokuʻu i ke ʻano, ka hoʻonohonoho ʻana a me ka pōpoki

Nā Palaki mai ke keʻokeʻo a keʻokeʻo me kahi poli a iʻa paha i ka poli, i ʻole nā silika piha, me ka chamfer a me ka notch, ʻae ʻia ka marbling.

1 kōpō
gliclazide	40 mg
metformin hydrochloride	500 mg

Nā mea kūʻokoʻa: sorbitol, povidone, criumarmellose sodium, magnesium stearate.

10 kamepiula - nā papaki blister (6) - nā ʻeke pepa.

Ka hana lāʻau lapaʻau

Hoʻohui ʻia nā lāʻau hypoglycemic no ka hoʻohana waha. ʻO Glimecomb® ka hui pūpū o ʻelua mau lawelawe hypoglycemic waha o ka hui biguanide a me ka hui sulfonylurea.

Loaʻa iā ia ka hana pancreatic a me ka extrapancreatic hana.

Kahuʻula - kumuliiia ailehu. Hoʻonui i ka mea huna o ka insulin e ka pancreas, hoʻonui i ka ʻike ʻana o nā ʻiʻo peripheral i insulin. Hoʻowalewale i ka hana o nā kinipili intracellular - kūlohelohe glycogen synthetase.

Hoʻihoʻi hou ia i ka mua o ka mea huna o ka mea huna o ka insulin, e hoʻēmi ana i ka manawa manawa mai ka manawa ʻai e ʻai ai i ka hoʻomaka ʻana o ka huna ʻana i ka insulin, a hoʻēmi ana i ka hyperglycemia postprandial.

Ma kahi o ka hoʻopiʻi ʻana i ka protein o ka hoʻoliʻi, hoʻāla ʻia ia i ka microcirculation, hoʻēmi i ka hoʻokeo o ka platelet a me ka hōʻuluʻulu ʻana, hoʻohemo i ka hoʻomohala ʻana o ka trombosis parietal, hoʻāliʻi i ka hanana o ka vascular a me ka pale ʻana i ka hoʻomohala ʻana o ka microthrombosis a me atherosclerosis, e hoʻihoʻi i ke kaʻina o ka physiet parietal fibrinolysis. Ke hoʻolōʻihi i ka hoʻomohala ʻana o ka retinopathy diabetes i ka papa non-proliferative, me ka maʻi nephropathy diabetes me ka hoʻohana lōʻihi, ʻike ʻia kahi emi nui i ka proteinuria. ʻAʻole ia e alakaʻi i ka hoʻonui nui o ke kaumaha kino, no ka mea aia kahi hopena nui ma ka wana o ka neʻe o ka huna ʻana o ka insulin a ʻaʻole ia i hoʻoulu i ka hyperinsulinemia, ke kōkua i ka hoʻemi ʻana o ke kaumaha o ke kino i ka mea hoʻomoea o ka lālani, ma ke ʻano o kahi meaʻai kūpono.

Metformin no nā pūʻulu nui o nā keiki nui. Hoʻemi ia i ka hoʻoliʻiliʻi o ka glucose i ke koko ma ka hoʻokaʻawale ʻana i ka gluconeogenesis i loko o ka ate, e hoʻemi ana i ka komo ʻana o ka glucose mai ka digestive tract a hoʻonui i ka hoʻohana ʻana i nā ʻōnaehana.

Hoʻemi i ka paneʻana o ka triglycerides, cholesterol a me LDL (i hoʻoholo ʻia i kahi ʻōpū ʻole) i ka serum o ke koko a ʻaʻole hoʻololi i ka paʻa o nā lipoproteins o kahi kūʻokoʻa ʻē aʻe. Kōkua i ka hoʻokū ʻana a hōʻemi paha i ke kaupaona ʻana. I ka nele ʻana o ka insulin i loko o ke koko, ʻaʻole i hōʻike ʻia ka hopena therapeutic. ʻAʻole kūpono kahi hopena hypoglycemic.

Hoʻonui i ka waiwai fibrinolytic o ke koko ma muli o ke kaohi ʻana o kahi inhibitor o ka profibrinolysin activator (plasminogen) kikoʻī.

Lapaʻau lāʻau

Hoʻomoe a me ka hoʻolele

Ma hope o ka lawelawe waha, ua kiʻekiʻe ke komo ʻana. I ka wā e lawe ai i ka pākahi o 40 mg Cmax i ka plasma ua loaʻa ma hope o nā hola 2-3 a i ka nui o ka 2-3 gg / ml. ʻO ka pilina protein Plasma he 85-97%.

Metabolism a me ka hoʻopā ʻana

Hoʻopili i ka puʻuwai. Nā hola T1 / 2 - 8-20. Hoʻopili nui ʻia ia ma ke ʻano o nā metabolites e nā keiki - 70%, ma o nā ʻōpū - 12%.

I ka poʻe maʻi nā maʻi, ʻaʻole i ʻike ʻia nā loli nui i loko o nā laikini pharmacokinetic.

Hoʻomoe a me ka hoʻolele

Ma hope o ka lawelawe waha, ʻo 48-52% ka lilo ʻana. Hoʻopili koke ʻia mai ka lolo. ʻO ka bioavailability piha (ma kahi ʻōpū ʻole) he 50-60%. Loaʻa ka Cmax i ka plasma koko ma hope o 1.81-2.69 h a ʻaʻole eʻoi aku i ka 1 1g / ml. ʻO ka haʻahaʻa me ka meaʻai e hōʻemi ana i ka Cmax i ka plasma ma 40% a me ka hoʻomōloe i kona loaʻa ʻana e 35 min. Hoʻololi ka pilina ʻana no ka protein. Hiki i ka metformin ke hōʻuluʻulu i nā pona koko ʻula.

ʻO T1 / 2 kahi mau hola 6.2, ua hoʻopiʻi ʻia e nā keiki, ka hapanui o ka loli (glomerular filtration a me ka hilo huna tubular) a ma o nā pūpū (a hiki i 30%).

- ke ʻano type 2 diabetes mellitus (ka non-insulin-dependant) me ka hoʻopiʻi ʻole ʻana o ka ʻaʻai meaʻai, hoʻomaʻamaʻa a me ka mālama ʻana me ka metformin a i ʻole gliclazide,

- ka pana o ka lāʻau o mua me nā lāʻau ʻelua (metformin a gliclazide) i nā mea maʻi me ka maʻi diabetes mellitus type 2 (non-insulin-dependence) me kahi kaila paʻa kūloko a paʻa pono.

Ke keu

Nā Hoʻomaka hiki ke kūpono i ka acidact lactic (ʻoiai ke metformin he ʻāpana o ka lāʻau), hypoglycemia.

Lāʻau: inā loaʻa nā hōʻailona o ka lactic acidosis, kāpae i ka lawe ʻana i ka lāʻau. Lactic acidosis kahi kūlana e koi ai i ka mālama mālama olakino, mālama ʻia ka lāʻau lapaʻau i loko o ka haukapila. ʻO ka hopena kūpono e pili ana i ka hemodialysis.

Hoʻohui nūhou

Hoʻonui i ka ikehu o ka ventricular extrasystole ma ke kua o ka glycosides cardiac.

ʻO nā lāʻau lapaʻau e pale i ka hematopoiesis pumehana o ka iwi e hoʻonui i ka hopena o ka myelosuppression.

Hoʻonui ka Ethanol i ka nui o ka acidact lactic.

Hoʻopau ka Metformin i ka Cmax i ka plasma a me T1 / 2 o ka furosemide e 31 a me 42.3%, kēlā.

Hoʻonui ka Furosemide i ka Cmax o ka metformin e 22%.

Hoʻonui ka Nifedipine i ka hoʻopili ʻana, hoʻonui iā Cmax i loko o ke koko koko, e hoʻolohi ana i ka hoʻopuka o ka metformin.

ʻŌpū a me ka lactation

Nā kuleana a me nā kūlana e waiho ai

E hoʻopaʻa inoa i ka lāʻau lapaʻau mai ka hiki ʻana o nā keiki, maloʻo, pale ʻia mai ka mālamalama, ma ke ʻano wela o ke kiʻekiʻe ma mua o 25 ° C. ʻO 2 mau makahiki kahi ola.

Kuhi ʻia ka wehewehe ʻana o ka lāʻau GLIMECOMB ma muli o nā ʻōkuhi no ka hoʻohana ʻana a ʻae ʻia e ka mea hana.

Ua loaʻa i kahi kime? Koho ia a kaomi Ctrl + Enter.

Nā rula no ka lawe ʻana i ka lāʻau lapaʻau Glimecomb a me nā lāʻau lapaʻau

ʻO Glimecomb e pili ana i nā lāʻau lapaʻau i hoʻohana ʻia no ka lāʻau maʻi type 2.

He lako nā mea hoʻohui me kahi hypoglycemic.

Ma hope o ka lawe ʻana i ka lāʻau, ua hoʻomaopopo ʻia ka normalization o ka pae glucose i ke koko o ka mea maʻi.

ʻO ka ʻike nui, ka hoʻonohonoho ʻana a me ke ʻano o ka hoʻokuʻu ʻana

ʻO ka lāʻau lapaʻau i koho ʻia e pili ana i nā mea hoʻohana hypoglycemic i lawe waha ʻia. ʻO ka hāmeʻa kahi hopena hui. I ka hoʻonuiʻana i ka hopena o ke kō, ua loaʻa iā Glimecomb kahi hopena pancreatic. I kekahi mau hihia, loaʻa ka hopena i ka hopena extrapancreatic.

ʻO ka hoʻonohonoho o ka lāʻau pili ka metformin hydrochloride i ka nui o 500 mg a me Gliclazide - 40 mg, me nā mea laea sorbitol a me ka sodium croscarmellose. ʻO kahi liʻiliʻi, nā magnesium stearate a povidone aia i ka lāʻau lapaʻau.

Loaʻa ka lāʻau lapaʻau i ke ʻano o nā cylindrical tablet i loko o ke keʻokeʻo, kaʻaila a i ʻole nā ʻulaʻula hoʻi. No nā papa, ʻae ʻia ka marbling. He pōpilikia a nā pōpō a me kahi bevel.

Hoʻololi ʻia ʻo Glimecomb i nā papa he 10 i loko o nā pūʻulu blister. ʻO ka pūpū he 6 mau paʻi.

Pharmacology a me ka pharmacokinetics

ʻO Glimecomb kahi lāʻau lapaʻau hoʻohui e hoʻohui i nā ʻenehana hypoglycemic o ka hui biguanide a me nā derivatives sulfonylurea.

Hoʻohālikelike ka lālā i nā hopena pancreatic a me nā hopena extrapancreatic.

ʻO Gliclazide kekahi o nā mea nui o ka lāʻau lapaʻau. He huaʻai ia he sulfonylurea.

hana ho okumu insulin
hoʻemi haʻahaʻa hoʻoliʻi koko,
hoʻemi i ka hoʻopili ʻana o nā platelet, ka mea e pale ai i ka hoʻokumu ʻana o nā lolo koko i loko o nā moku koko,
ʻano maʻamau o ka vvaima koi.

Hoʻopili ke Gliclazide i ka hopena o ka microthrombosis. I ka wā lōʻihi o ka hoʻohana ʻana i ka lāʻau i loko o nā mea maʻi me ka nephropathy maʻi, ʻike ʻia kahi hōʻemi i ka proteinuria (ʻo ka noho ʻana o ka protein i ka urine) ua ʻike ʻia.

Hoʻopilikia ke Gliclazide i ke kaumaha o ka mea maʻi i lawe i ka lāʻau. Me kahi papa kūpono i nā maʻi me ka maʻi maʻi e lawe ana iā Glimecomb, ʻike ʻia ka nui o ka kaumaha.

ʻO Metformin, kahi ʻāpana o ka lāʻau lapaʻau, e pili ana i ka hui biguanide. Hoʻonui ka mea i ka nui o ka glucose i ke koko, ke kōkua pono e hoʻonāwaliwali i ke kaʻina o ke kīʻaha o ka glucose mai ka ʻōpū a me ka ʻawa. Kōkua ʻo Metformin e hana wikiwiki i ke kaʻina hana e hoʻohana ai i ka glucose mai nā kino kūwaho o ke kino.

ʻO nā mea haʻahaʻa e hoʻemi nei i ka cholesterol, nā lipoproteins haʻahaʻa haʻahaʻa. I kēia hihia, ʻaʻole i pili ka Metformin i ka pae o nā lipoproteins o kahi kūʻokoʻa ʻē aʻe. E like me Gliclazide, e hōʻemi ana i ka paona o ka mea maʻi.

ʻAʻohe hopena i ka haʻalele ʻana o ka insulin i ke koko. ʻAʻole ia e hāʻawi i ke ʻano o nā hopena hypoglycemic. ʻO nā Gliclazide a me ke metformin ʻokoʻa ʻē aʻe a hoʻopuka ʻia mai ka mea maʻi.

Hoʻohālikelike ʻia ka Gliclazide e kahi kiʻekiʻe o ke komo ʻana ma mua o ka Metformin.

ʻO ka pae kiʻekiʻe loa o Gliclazide i ke koko ua loaʻa ma hope o 3 mau hola mai ka manawa o ka hoʻonā ʻana o ka lāʻau. Hoʻopau ʻia ka waiwai ma o nā keiki (70%) a me nā ʻōpū (12%). ʻO ka hoʻopau hapa-hapalua ke ola i 20 mau hola.

ʻO ka bioavailability o Metformin he 60%. Hoʻonui nui ka mea i loko o nā kaila koko ʻula. ʻO ka hapalua-ola kahi 6 hola. ʻO ka hoʻihoʻi ʻana mai ke kino e hele mai ana ma o ke akea me ka ʻōpū (30%).

Nā hōʻailona a me nā contraindications

Hoʻomaopopo ʻia ka lāʻau lapaʻau no nā maʻi maʻi me ka maʻi diabetes type 2 inā:

ʻo ka hoʻomaʻamaʻa mua ʻana me ka ʻaʻaʻai a me ka hoʻomaʻamaʻa ʻaʻole i loaʻa ke kūpono kūpono.
aia kekahi mea e pono ai e hoʻololi i ka hui hoʻohui ʻana i hoʻohana ʻia me ka hoʻohana ʻana iā Gliclazide me ka Metformin i nā maʻi me nā maʻi hoʻoliʻi koko.

Hōʻike ʻia ka lāʻau lapaʻau me kahi papa inoa o nā contraindications, ma waena o ia:

ka loaʻa ʻana o ka maʻi maʻi type 1
ka hoʻomaloka pilikino ʻana i nā ʻāpana o ka lāʻau lapaʻau,
hana koʻikoʻi nā keiki,
hapai
pūpū hema
lactic acidosis,
puʻuwai paʻakikī
coma maʻi maʻi
lactation
nā maʻi like ʻole
myocardial infarction
maʻi maʻi phi
precoma maʻiʻaʻai
interventions mua mua,
ka manawa o ka mea maʻi e hoʻomoʻi nei i nā haʻawina x-ray a me ka hoʻokolohua e hoʻohana ana i ka radioisotopes me ka hoʻopuka ʻana i nā mākaʻi iodine-kūlike (ua pāpā ʻia i nā lā 2 mau lā ma hope a ma hope o kēia mau haʻawina).
nā hōʻeha ʻeha
nā haʻalū i kūʻole i kahi kūlana o ke puʻuwai a me nā maʻi,
pauna aho hanu
make wai make,
kaohi koko haʻahaʻa (hypoglycemia),
nā maʻi ʻehaʻeha nui
humuho waiwa,
pāāha ʻā ʻia ma ke kino,
pili i nā mea maʻi me ka meaʻai hypocaloric,
lawe ʻia
maʻi ketoacidosis maʻi.

Nā koho o nā loea kūikawā a me nā maʻi

Mai nā loiloi o nā mea maʻi, hiki ke hoʻoholo ʻia e hoʻemi maikaʻi ʻo Glimecomb i ke kō koko koko a maikaʻi hoʻi, akā hoʻi, ke hoʻomau nei nā kauka i kona mālama ʻana no ka nui o nā hopena o ka ʻaoʻao.

ʻAe ʻia i ka lāʻau lapaʻau i hōʻike ʻia e ka lāʻau lapaʻau. Loaʻa kona kumukūʻai mai 440-580 rubles. ʻO ke kumu kūʻai o nā ʻāpana ʻē aʻe, mai 82 a 423 mau rubles.

Manaʻo mākou i nā ʻatikala e pili ana

Glimecomb: nā ʻōlelo no ka hoʻohana ʻana, ke kumukūʻai, nā loiloi, nā hoʻohālike

Hōʻalo ka lāʻau lapaʻau, kuhikuhi i ka kāohi ʻana i ke kiʻekiʻe o ka glucose i ke koko o ka mea maʻi me ka maʻi maʻamau 2.

ʻO ka hoʻohui pū ʻana i ka Metformin a me Gliclazide, he hana maikaʻi loa ʻo Glimecomb i ka pilikia o ka kaila koko, kahi o ka mālama e pono e mālama.

Ma hope o nā mea āpau, ʻaʻole ikaika i kēia pono hana, a no laila, ʻaʻole kūpono i nā mea maʻi me nā haʻuki gula a me ka hoʻokūkū a me ka hoʻokau. Eia nā mea pono e pono ai e ukali i ka wā e lawe nei i kēia lāʻau lapaʻau.

Ke noi

Hoʻolako ʻia ʻo Glimecomb no ka hoʻohana ʻana i nā mea maʻi me ka loaʻa ʻana o ka maʻi maʻi maʻi 2.

He mea nui ia e kāl ana kēia lāʻau lapaʻau i ia ʻano ʻano o ka maʻi i ka manawa e hoʻōla ai ka hana kino a me kahi palapala ʻai hoʻokaʻa kūikawā i lawe mai i ka hopena kūpono.

ʻO kēia ka mea i kuhikuhi i kēia lāʻau lapaʻau ma ka hihia i hiki ʻole ke hana ʻia i ka lāʻau paʻakikī, hui pū i nā lāʻau ʻelua (ʻoi aku ka hoʻokaʻawale ʻana me ka metformin a me gliclazide) i hui pū me ka hana kino a me ka ʻai.

I ka wā o ka mālamaʻana me Glimecomb, kiaʻi mau ka mālama ʻana i ke kōpaʻa koko o ka mea maʻi ma mua a ma hope o ka ʻai ʻia e pono ai (pono e uku ʻia i ka pule mua o ka komo ʻana).

E hoʻokuʻu i nā palapala

Loaʻa i ka Glimecomb kahi puka hoʻokuʻu hoʻokahi i ke ʻano o nā papa. Ua mahele ʻia ka lāʻau lapaʻau e ke ʻano o ka hoʻopiha ʻana i nā pūʻulu penei:

i loko o nā hue plastik i ka pauka pepa. Aia i loko o kēia kīʻaha he 30, 60 a 120 mau papa,
i loko o kahi pahu pahu me nā pololi o nā papa he 10 i hoʻokahi. Hoʻokahi ka pūpū 6 makana,
i loko o kahi pahu kāleka me nā palaha o nā papa he 20 i loko o hoʻokahi. ʻO ka pānaʻi hoʻokahi ʻano 5 kōpī.

ʻO nā papa i loko o ke ʻano o kahi silopani papa, ʻoi loa ka keʻokeʻo (beige, kinikini a me nā melemele ke ʻae ʻia). He pōpilikia a nā pōpō a me kahi bevel. ʻO ka hoʻonohonohoʻana o Glimecomb e pili ana i ka metformin a me hydrochloride ma ka nui o 500 mg, me ka glycoslide 40 mg. Eia kekahi, ʻo povidone, magnesium stearate, sorbitol a me ka sodium croscarmellose aia i loko o kahi liʻiliʻi.

Loaʻa wale nā papa papaʻaʻike i nā papa inoa.

Nā hopena hopena

Hiki i nā hopena leʻaleʻa i hiki ke ʻike ʻia i ka wā e lawe ai iā Glimecomb i ka mea pinepine ma muli o kona overdose a i ʻole kūpono ʻole me ke kino maʻi kūloko o ka mea maʻi.

A ʻo nā mea e pili ana i ka derony o ka sulfonylurea e hoʻonui i ka hōʻemi i ka nui o nā hopena o ka ʻaoʻao.

Hoʻohana ʻo ia ka hana kūpono no ka mea maʻi me ka hoʻomohala ʻana i ka acidosis lactic, i hele pū me ka migraines, nāwaliwali mau, ka nui o ka hiamoe, a me ka hōʻoki ʻana i nā ʻeha ma ka ʻōpū o ka ʻōpū a me ka hoʻoluhi ʻana i ke kaomi ma loko o ka wahī.

Hiki i nā hopena i ka makemake i ka wā e lawe ai iā Glimecomb:

ka hoʻomohala ʻana o ka hypoglycemia a me ka lactocidosis me nā hōʻailona eha e pili ana,
ke ʻano o ke kinipōpō a me ka lemulewa,
ka leʻaleʻa mau ʻana i ka ʻōpū o ka ʻōpū,
hoʻemi i ka makemake maʻamau,
ka manawa maʻamau o ka loaʻa ʻana o ke koko i loko o ka waha a me ka ʻāʻī
ke ʻano o ka hoʻomohala ʻana i nā maʻi o nā puʻuwai koʻikoʻi (hepatitis, etc.)
maʻi kūlohelohe i nā mea like o ka pūnaehana (urticaria, itching, tumors,
ʻulaʻula, nā ʻano rashes),
aia nā hihia o ka hōʻemi kino a ke lawe ʻana iā Glimecomb.

Inā loaʻa iā ʻoe nā hōʻailona ma luna, pono e kūkā koke i kahi loea.

Wahi a ka paʻakikī o nā hopena ʻaoʻao, pono e hoʻokaʻawale ke kauka i ka nui o ka lāʻau a hoʻoliʻi paha iā ia me kahi koho e ʻae ʻia (e haʻalele loa i ka hoʻohana ʻana iā Glimecomb).

I ke alakaʻi ʻana i nā lāʻau lapaʻau Lūkia, e hoʻohālike ke kumukūʻai o Glimecomb mai 200 a 600 mau rubles, e hilinaʻi nei i ka pauka a me ka helu o nā papa i loko, a me ka mea i hoʻolako a me nā wahi kūʻai.

Ma ke kumukūʻai o ka lāʻau lapaʻau i hiki iā ia ke kūpono no kahi laulā o ka lehulehu, no laila e koi ʻia ma ka mākeke pharmacological. No laila ke kumukūʻai kumukūʻai ma nā hale kūʻai pūnaewele no nā papa Glimecomb he 40 mg + 500 mg 450 mau rubles no ka pāleka, aia kahi 60 papa.

I nā lāʻau lapaʻau pūnaewele, ʻo ke kumukūʻai o ka lāʻau no nā papa 60 no like 500-550 rubles.

ʻO nā mea hoʻohālike Glimecomb kēiaʻano:

ʻO Gliformin (ma kahi o 250 mau rubles no 60 mau papa), ka lula o ka hana a ua like ia me ka Glimecomb, ua like ka mea like, akā naʻe ke ʻano o ka insulin i kēia lāʻau lapaʻau e hoʻonani iki.
Diabefarm (no nā papa 60, pono ʻoe e uku e pili ana i ka 150 mau rubles). Aia ia ka mea e paʻa ai ka glyclazide - 80 mg, ke kuhikuhi nei i ka hoʻopau ʻana i nā pilikia like me Glimecomb.
ʻO Gliclazide MV (ke kumukūʻai kumukūʻai no nā papa 60 he mau rubles). He ʻano kūlike ia mai Glimecomb, aia wale nō ka 30 mg o glycoslazide. ʻO nā ʻōmamaʻa no ka hoʻohana pono ʻana e like me ka lāʻau lapaʻau mua.

Glimecomb: mau ʻōlelo no ka hoʻohana ʻana, ke kumukūʻai, nā loiloi a me nā analog

I kekahi manawa pono e loaʻa nā mea maʻi me ka maʻi diabetes i nā lāʻau lapaʻau i ka manawa hoʻokahi. Akā he mau mea pono e hoʻopili pū ai kāna palapala i nā mea e pono ai. Hāʻawi lākou iā ʻoe e hana me hoʻokahi papa. ʻO "Glimecomb" he lāʻau lapaʻau e loaʻa ana i nā mea pono. E noʻonoʻo i nā ʻōkuhi no kona hoʻohana ʻana i ka kikoʻī.

Hoʻohālikelike me nā kikowaena

He loaʻa i kēia lāʻau lapaʻau ka helu o nā mea hoʻohālike e like me ka hoʻonohonoho ʻana a me nā waiwai. E nānā pono i kahi mea hiki ke hoʻololi ke kauka Glimecomb.

ʻO ka Hoʻonanea. Kumukūʻai - mai 250 rubles no ka pākauea (60 mau ʻāpana). Mea hoʻomohala a JSC Akrikhin, Lūkia. Nā hānona metformin. Hoʻohālike ʻia nā ʻano o nā papa, akā ʻaʻole no nā mea a pau. Hoʻohana e hoʻopaʻa i ka paona kino.

Hoʻopape. U kumukūʻai - 160 rubles (60 papa). Hoʻopuka i ka hui "Pharmacor", Rūsia. Loaʻa kona nui aʻe gliclazide (80 mg), ua like ke koena o nā waiwai.

Gliclazide. Mai 200 rubles i kēlā me kēia pā (60 ʻāpana) Mea Hana - Canonfarm, Rusia. Hoʻopili i nā gliclazide liʻiliʻi i ka hoʻohui (30 mg). Kōkua i ka mālama mau i ka momona. ʻO kahi hoʻohui hou ke kumu kūʻai haʻahaʻa.

Amaril. Kēia mau papa mai ke 800 rubles no kēlā me kēia pā. Hana ʻia e Handoc Inc., Korea. ʻO ia kahi mea hoʻohui hui no ka maʻi maʻi maʻi (glimepiride + metformin). Hoʻohālikelike nā ʻōmole. He ʻoi aku ka uku o ka minus.

Galvus. Hoʻomaka ke kumu mai ka 1600 rubles. ʻO ka mea hana hana ʻo Novartis Pharma, Kelemānia. Ke hoʻohui lāʻau (vildagliptin + metformin). Loaʻa iā ia nā hopena like a me nā pāpā ʻana i ka komo ʻana me Glimecomb. E oi aku ke kumukūʻai, akā i kekahi manawa ke ʻoi aku i ʻoi aku ka maikaʻi ma mua o kona hoa.

Ma keʻano laulā, nā maʻi maʻi me ka ʻike e pane maikaʻi i kēia lāʻau lapaʻau. Hoʻomaopopo ʻia ka ʻoluʻolu o ka hoʻomaʻamaʻa ʻana i ka wā o nā ʻano mea ʻelua e hana i ka papa like. I kekahi manawa kākau lākou ʻaʻole e kūpono ka hoʻoponopono. Loaʻa nā hopena ʻaoʻao.

ʻO Victor: "Ua loaʻa iaʻu kahi maʻi diabetes 2. Ua hoʻohana pinepine wau e lawe i ka metformin a me gliclazide i kaʻawale. ʻAʻole kūpono ia a maʻalahi hoʻi. Ua lawe ke kauka i Glimecomb. Ma waho aʻe o ka ʻoiaʻiʻo e inu nei au i kahi papa hoʻokahi ma mua o ʻelua, ke manaʻo maikaʻi nei au i ka maikaʻi. ʻAʻole i loaʻa iaʻu kekahi hopena ʻaoʻao, ua māʻona wau me ka lāʻau lapaʻau. "

Valeria: "ʻO 63 koʻu makuakāne he 63 mau makahiki, i mālama ʻia i ʻelua mau makahiki i hala. Ua hoʻomaʻamaʻa ʻia nā mea he nui, ua pau nā mea āpau i ka hana ʻana. Ua ʻōlelo mai ke kauka iaʻu e hoʻāʻo iā Glimecobm, akā ua haʻi aku e pono iaʻu e hahai i kahi meaʻai koʻikoʻi a nānā i koʻu olakino. Ua hala a hala ʻekolu malama i kēia manawa, e hoʻoponopono nei nā ʻōkula, a ua emi ka nui. ʻAe ʻoluʻolu ka Makua. "

ʻO ke aloha: “Ua lōʻihi wau i mālama ʻia me kēia hōʻola. Makemake wau i ka māhele o ka haʻahaʻa haʻahaʻa a me ka maikaʻi maikaʻi. ʻAʻole hoʻonui ka Sugar, manaʻo nui wau, ʻaʻohe hopena pākuʻi a ʻaʻohe. "

Gregory: “Ua kuhikuhi aku ke kauka iā Glimecomb. Ma hope o kahi mahina o ka hoʻopili ʻana, pono wau e hoʻololi i ka leʻaleʻa. ʻAʻole kūpono wau. Hoʻomaka ka pilikia ʻo Digestive, a me nā poʻo i ke poʻo. Wahi a ke kauka ʻaʻole ka mea āpau e hana. Akā ʻaʻole i kūpono iaʻu. ”

Alla: "Ua koho lākou iā Glimecomb. Ua mālama ʻia iā ia no ʻelua pule, akā ua hōʻemi ʻia ʻo ia e hoʻololi i kahi ʻē aʻe. ʻAʻole loli o ke ʻano o ke kō, ʻoiai, ua kū aʻe iki. Akā no kēlā kumukūʻai, ʻaʻole ia he huhū ia no ia ʻano kūpono. "

ʻO Glimecomb i hoʻohui i ka lāʻau lapaʻau hoʻohaʻahaʻa no ka maʻi maʻi

ʻO ka maʻi maʻamau i loko o ka'āina he ʻelima mau maʻi koʻikoʻi mai ka mea i pio ai kā mākou mau mea kanu a make. ʻOiai e like me nā manaʻo koʻikoʻi, a hiki i ka 230 tausani mau maʻi maʻi i kēlā me kēia makahiki mai ka maʻi maʻi ma ka ʻāina. ʻAʻole hiki i ka hapa nui o lākou ke mālama i ko lākou kūlana me ka ʻole o nā lāʻau lapaʻau maikaʻi.

ʻO nā mea kaulana loa a i hoʻāʻo ʻia i ka manawa e hoʻokaʻawale ʻia mai nā kime mai nā hui o biagunides a me sulfonylureas. Ua aʻo nui ʻia lākou i ka hoʻomaʻamaʻa ʻana a me nā noiʻi he nui, ua hoʻohana ʻia nā pae āpau o ke ʻano maʻi type 2.

Ua hoʻokumu ʻia ka lāʻau lapaʻau Glimecomb (ma ke ʻano honua Glimekomb) i ke kumu o ka biagunide a me ka hoʻomākaukau ʻana o ka sulfonylurea, e hui pū ana i nā pono o ka metformin a me ka glycazide, e ʻae ana i ka glycemia me ka hoʻomau a palekana.

Lapaʻau Kūloko

Ka hiʻohiʻona o ka hana o nā mākau hoʻomaʻamaʻa maʻamau o ka mea paʻakikī e hoʻoweliweli i kēia mau kihi.

ʻO ka mahele mua o ka lāʻau lapaʻau ka mea i hoʻokaʻawale i kahi hanauna hou o ka sulfonylureas. ʻO ka hoʻohaʻahaʻa hilo i ka wai o ka lāʻau i loko o ka hoʻonui ʻana i ka hana o ka insulin endogenous e nā β a sela o ka pancreas.

Mahalo i ka hoʻoulu ʻana o ka muscle glycogen synthase, hana ʻia ka hoʻohana ʻana o ka glucose i nā muscute, ʻo ia ka mea ʻaʻole i loli maoli ka momona.

Hoʻolimalima i ka mole glycemic o gliclazide i kekahi mau lā, ʻo ka metabolic latent diabetes.

Mai ka manawa o ka loaʻa ʻana o nā mea kanu i loko o ka pānao ʻana i ka hoʻomaka ʻana o ke kāpili ʻana o ka insulin ponoʻī me ka lāʻau lapaʻau, ʻoi aku ka liʻiliʻi o ka manawa e pono ai ma mua o ia ʻole.

ʻO ka Hyperglycemia, e hōʻike pinepine iā ia ma hope o ka hoʻokomo ʻana i nā kālaiʻu, ʻaʻole i pilikia ma hope o ka hoʻohana ʻana o gliclazide. Hoʻonui ka platelet, ka hana fiblinolytic a me ka heparin me ka lāʻau lapaʻau.

ʻO ka hoʻonuiʻana i ka heparin, he lāʻau lapaʻau a me nā waiwai antioxidant.

ʻO ka hana o nā hana o ka metformin, ka lua o ka hana maʻamau o Glimecomb, kau ʻia i ka hoʻemi ʻana o ka nui o ke kōpaʻa basal ma muli o ka kaohi o ka glycogen i hoʻokuʻu ʻia mai ka ate.

ʻO ka hoʻonuiʻana i ka ʻike o nā mea nānā, ua hoʻemi ʻia ka lāʻau lapaʻau i ka pale ʻana o nā maʻi i ka insulin.

Ma ka hoʻokaʻawale ʻana i ka hana o nā glucose mai nā protein a me nā momona, e wikiwiki ana i kona keʻa ʻana i ka ʻūlū mākala no ka hoʻohana mau ʻana.

I loko o nā pākuʻi, metformin pale i ka hoʻopili ʻana o ka glucose ma o nā paia. Hoʻoulu ka mana o ke koko: ʻo ka piʻi ʻana o ka kolamu, ʻo ka triglycerol a me ka LDL ("hewa" kolamu) ke hoʻemi nei, hoʻonui ʻia ka pae o HDL ("maikaʻi" cholesterol). ʻAʻole pā ka Metformin i nā seleka β ke kuleana no ka hoʻokumu ʻana i kā lākou insulin. Ma kēia ʻaoʻao, e hoʻopaʻa ke kaʻina i ka gliclazide.

ʻO wai ka mea kūpono iā Glimecomb

ʻAʻole i kuhikuhi ʻia ka lāʻau hoʻohui.

ʻO ka maʻi maʻi maʻi me ka maʻi ʻano ʻehā,
Me ka ketoacidosis (ka maʻi maʻi),
Me ka maʻi maʻi precoma a me ka coma,
ʻO nā maʻi me ka maʻi ʻaulepa koʻikoʻi
Me ka hypoglycemia,
Inā hiki i nā maʻi koʻikoʻi (maʻiʻai, kūmole, pīhoihoi) hiki i nā keiki a i ʻole ke aʻalolo o nā aʻalolo,
Ke hele nei ka poʻe me nā alaʻai ma ka wīwī o ka oxygen (ʻana i ka naʻau, ka puʻuwai a me nā hāʻule ʻana o ka hanu).
Nā makuahine hāpai a me lactating
Me ka hoʻohana ʻana o ka miconazole,
I nā kūlana e pili ana i ka hoʻokaʻawale ʻana o nā papa me ka insulin (nā maʻi, nā hana, nā hōʻeha koʻikoʻi)
Me ka hypocaloric (a hiki i ka 1000 kcal / lā) kaʻai,
No ka poʻe inu waiona me ka waiʻona huakino,
Inā ʻoe he moʻolelo o ka lactic acidosis,
Me ka hypersensitivity i nā mea kanu o ka lāʻau lapaʻau lāʻau.