Ke ʻano lāʻau Zanocin: ʻōlelo aʻoaʻo no ka hoʻohana

Loaʻa nā Zanocin i loko o nā palapala hoʻohālikena:

• Nā hopena no ka infusion (100 ml i loko o nā hue, 1 pahu i loko o kahi pahu pahu)
• Nā ʻāpana, nāʻaina a i ʻole ʻoniʻoni ʻia ʻoniʻoni (10 pcs. In blisters, 1 blister in a cardble packle).

ʻO ka hoʻonohonohoʻana o 1 papa a me 100 ml o ka hopena infusion e komo i ka mea ikaika: ofloxacin - 200 mg.

Lapaʻau lāʻau

ʻO ka Ofloxacin, ka mea ikaika o ka lāʻau, he ākea ākea ākea antimicrobial i wahi o ka hui fluoroquinolone. Hoʻopuka ia i ka bacteria gzimase DNA bacteria, nona ke kuleana no ka supercoiling, a, ma ia mea, e hoʻololi i ka hoʻokū o ka DNA o nā microorganisms (destabilization o nā kaulahao DNA ka mea e make ai lākou). Loaʻa nō hoʻi ka waiwai i ka hopena bactericidal.

Kūpaʻa ikaika ka Ofloxacin i kēia mau microorganisms i kēia:

• Anaerobes: Nā mea i hana ʻia Clostridium,
• Aerobes Gram-néleple: Serratia marcescens, Acinetobacter calcoaceticus, Pseudomonas aeruginosa (wikiwiki ka lilo), Bordetella pertussis, Providencia stuartii, Providencia rettgeri, Citrobacter koseri, Citrobacter freundii, Proteus vulgareroeroberioerobacterioerobius Klebsiella pneumoniae, Klebsiella oxytoca, Haemophilus influenzae, Haemophilus ducreyi, Morganella morganii, Moraxella catarrhalis,
• aerobes gram-positive: Streptococcus pyogenes, Streptococcus pneumoniae (penicillin-sensitive strains), Staphylococcus saprophyticus, Staphylococcus epidermidis (methicillin-sensitive strains), Staphylococcus aureus (methicillin-sensitive strain),
• ʻO kekahi: Ureaplasma urealyticum, Chlamydia pneumoniae, Chlamydia trachomatis, Mycoplasma pneumoniae, Mycoplasma hominis, Legionella pneumophila, Gardnerella vaginalis.

Ma ka hapanui o nā hihia, hōʻike ʻia ka kūlohelohe e ka Treponema pallidum, Nocardia asteroides, ka nui o nā koikoi o Streptococcus spp., Enterococcus spp., Anaerobic bacteria (me ka Clostridium difficile, Bacteroides spp., Fusobacterium spp., Peptococcus spppppp. . ^ E Ha yM.

Lapaʻau lāʻau

Ma hope o ka lawelawe waha, ua paʻa koke ʻia ʻo ofloxacin a kokoke loa (kokoke i ka 95%). ʻOi aku ka bioavailability o 96%, a me ka nui o ka mana ʻana i ka protein plasma he 25%. Ke hoʻokō nei, ua hoʻokō ka nui o ka piʻi ʻana o ka waiwai ma hope o nā hola 1-2 a ma hope o ka hoʻokele ʻana i nā inika o 200 mg, 400 mg a me ka 600 mg ka like me ka 2.5 gg / ml, 5 μg / ml a me 6.9 μg / ml, ma kēlā me kēia.

Hiki i ka ʻai ke hoʻemi i ka helu absorption o ka mea hana a ka Zanocin, akā ʻaʻole i hoʻopilikia nui ʻia ka bioavailability.

Ma hope o kahi infusion intravenous hoʻokahi o 200 mg ofloxacin, e mau ana no 60 mau minuke, ʻo ia ka awelika plasma nui o ka nui o ka waiwai o 2.7 μg / ml. 12 mau hola ma hope o ka hoʻokele ʻana, hāʻule kona waiwai i ka 0.3 μg / ml. Loaʻa nā kūlike o ka kūlike ma hope o ka hoʻolaha ʻana o nā liʻiliʻi he 4 mau liʻiliʻi o ka Zanocin. Loaʻa nā awelika haʻahaʻa a me nā pualikepau kūloko kiʻekiʻe ma hope o ka hoʻokele ʻana o ka maʻi ofloxacin i kēlā me kēia mau hola 12 no 7 mau lā a ʻo 0.5 a 2.9 gg / ml, kēlā me kēia.

Loaʻa ka nui o ka hoʻoili ʻana i ka 100 lita. Hoʻomaʻamaʻi maikaʻi ʻia ʻo Ofloxacin ma luna o nā mea ola a me nā ʻōpala o ke kino, ka komo ʻana i ka mea huna o ka kelepa prostate, nā kopa (alveolar macrophages, leukocytes), bile, limu, urine, ka ʻili, ke ʻano hanu, ʻalopō, nā ʻōpala palupalu, pelvic a me nā ʻōpū o ka ʻōpū. Hoʻopili maʻalahi ka waiwai i ka pili o ke koko-lolo a me ka papa plasental, i hoʻopuka ʻia i loko o ka waiū umauma a hoʻoholo ʻia i ke aniani cerebrospinal (14-60% o ka nui i hoʻopaʻa ʻia).

Hoʻopili ʻia nā mea kolo o Ofloxacin i loko o ke ake (ma ka 5% o ka lāʻau i lalo i ka biotransformation), a me nā metabolites nui e demethylofloxacin a me ofloxacin-N-oxide. Hoʻololi ʻia ka hapalua hapa ola mai 4,5 a 7 mau hola a ʻaʻole ia e hilinaʻi ma kahi pākaʻi. Hoʻopili ʻia ka pūlea ma loko o ka urine - a ʻoi aku ka 75-90% i loli ʻole, e pili ana i ka 4% o ka wāloxacin a hoʻōla ʻia i ka bile. ʻO ka hoʻomaʻamaʻaʻokoʻa ʻole iʻoi aku ma mua o 20%. Ma hope o ka manawa hoʻokahi o ka lāʻau i loko o kahi kaʻe o 200 mg, ua hoʻoholo ʻia ka ofloxacin i loko o ka urine no 20-24 mau hola.

I nā maʻi me ka maʻi hepatic a i ʻole paha e lohi ka nui o ka neloxacin elimination. ʻO ka hōʻiliʻili ʻana o nā mea i loko o ke kino ke kaawale nei. I ka wā o ka hana hemodialysis, a hiki i ka 10-30% o ka hana ikaika ua hoʻākoakoa ʻia ʻo Zanocin.

Nā hōʻailona no ka hoʻohana ʻana

• Nā maʻi: ka urinary tract, gynecological (me ka gonorrhea, chlamydia), nā hui ENT, nā wahi a me ka hanu, nā kino ʻike, nā palupalu palaleka a me nā ʻili, gastrointestinal tract,
• Endocarditis
• ʻO ke maʻi (ʻo kahi mahele o ke ʻano hui like me ka lālani lua-laina),
• ʻO nā maʻi maʻi.

Nā ʻōkuhi no ka hoʻohana ʻana i ka Zanocin: ʻano a me ka helu ʻana

Kahi ʻia ke ʻano o ka Zanocin.

ʻO ka lāʻau lapaʻau i ke ʻano o nā papa i lawe ʻia ma ke alo. Hoʻoholo ʻia ka palapala noi e nā hōʻike:

• Nā maʻi ʻeha a me ka hoʻopiʻi ʻana i nā ʻāpana o ka uria: 2 mau manawa i kahi lā, 200 mg kēlā me kēia,
• Nā maʻi o nā ʻano etiology: 2 mau lā i ka lā, 200-400 mg,
• Chlamydia: 2 manawa i ka lā, 300-400 mg no nā lā 7-10,
• ʻO ka prostatitis i kumu e E. coli: 2 mau manawa i ka lā, 300 mg kēlā me kēia (a i 6 wiki),
• Gonorrhea kōpili i hoʻopiʻi ʻole ʻia: hoʻokahi 400 mg.

Hoʻohana ʻia ka Zanocin i loko o kahi hopena o ka hoʻonāhi no infusion, drip, infusion. Hoʻomaʻamaʻa ʻia ka lāʻau lapaʻau:

• ʻO nā maʻi maʻi o ka maʻi paʻakai: 2 mau manawa i ka lā, 200 mg kēlā me kēia
• ʻO nā maʻi o Intraabdominal, ka maʻi ʻeha o nā palupalu palaleka, ka ʻili, ke ala o ka hanu: mau manawa 2 i ka lā, 200-400 mg.

Nā hopena hopena

I ka wā o ka hoʻomehana, hiki i nā hopena aʻe ke ʻano:

• Pūnaehana pīhoihoi waena: nāwaliwali, maʻi ʻole, ke hiamoe ʻole, ka hōʻeha, ka headophobia,
• Pūnaehana Digestive: ʻeha palupalu, nausea, ke nānā ʻana, ka hoʻohālikelike, ka anorexia,
• Nā maʻi pākēneka: ka wela, ka ʻūlū, ke aniani, ka ʻeha.

Ke keu

ʻO nā ʻōmaʻomaʻo o kahi overdose o Zanocin: ka lōʻihi o ka manawa QT, dizziness, drowsiness, disorientation, lethargy, confingness, luka. I kēia hihia, ua kauoha ʻia ka gastage lavage a me ke ʻano hōʻailona. Me ka lōʻihi o ka manawa QT, pono ka mākaʻikaʻi mau ʻana o ka ECG.

Hoʻohui nūhou

ʻO ka hopena o ka hoʻohana ʻana o Zanocin e hōʻemi i nā antacids (hoʻomālamalama ʻia i loko o ka ʻohi ʻana).

I kekahi mau hihia, hoʻonui paha ʻo Zanocin i ka kiʻekiʻe o ka theophylline i ka plasma.

The analogues of Zanocin are: Dancil, Zoflox, Tarivid, Ofloxacin, Ofloxacin Zentiva, Ofloxacin-Teva, Ofloxacin Protekh, Ofloxin, Uniflox, Phloxal.

Hōʻikeʻike e pili ana iā Zanocin

Wahi a nā loiloi, ke hoʻākāka pinepine ʻia ʻo Zanocin i nā mea maʻi ma ke ʻano o ka mālama ʻana o ka metroendometritis, perimetritis a me salpingoophoritis, a me nā maʻi urological a me nā maʻi gynecological. Wahi a nā poʻe loea, ua loiloi ka lāʻau e maikaʻi loa a me nā ʻano maikaʻi, ʻoiai maikaʻi ka hana ʻana o theloxacin i nā māka kumu kumu o kēia mau maʻi. Hoʻomaʻamaʻa maikaʻi ka hapanui o ka maʻi maʻi i ka hōʻola ʻana, ʻo kahi mea liʻiliʻi wale nō o lākou i hōʻeha i ke ʻano o ke ake ʻana o ka maʻi, ke ʻano a me ke anorexia, a me ka hōʻike ʻana o nā photosensitivity i ka wā o ka mālama ʻana me Zanocin i ka manawa mahana.

Hoʻopili ʻia ka Ofloxacin ma o nā keiki, e hiki ai iā ʻoe ke hoʻopōmaikaʻi i nā ʻōnao ʻana e hui pū me nā maʻi urological. Aia i ka lā 5-7th ma hope o ka hoʻomaka ʻana o ka mālama ʻana, nalo aku ka bacteriuria a hoʻomaikaʻi hou ka maʻi o nā mea maʻi. Loaʻa nā hopena ʻaoʻao.

Hiki ke hoʻohana ʻia ʻo Zanocin e mālama i nā maʻi maʻi i hoʻoiho ʻia e ka Escherichia coli a me nā pseudomonas. Eia kekahi, he hopena immunomodulating. No laila, kuhikuhi pinepine nā kauka iā ia no ka mālama ʻana i ka maʻi maʻi a me ke kanesa, ʻoiai ke ʻano nei nā ʻano like i ka hoʻemi ʻana i ke kino ʻole.

ʻO nā huahana Pharmacological o ka lāʻau Zanocin

Lapaʻau lāʻau Ofloxacin ((±) -9-fluoro-2,3-dihydro-3-methyl-10- (4-methyl-1-piperazinyl) -7-oxo-7H-pyrido1,2,3-de-1,4- benzoxazine-6-carboxylic acid) he mea antimicrobial o ka hui fluoroquinolone. ʻO ka hopena bactericidal o ka theloxacin, e like me nā quinolones fluorinated, aia ma muli o kona hiki ke pale aku i ka gyrase enzyme bacterial.
Ka uhi ʻana o ka antibacterial o ka lāʻau i ka microorganism i kū i nā penicillins, aminoglycosides, cephalosporins, a me nā microorganism me nā pale kaua lehulehu.
Zanocin OD - kahi lāʻau lapaʻau me ka hoʻokuʻu i ka lōʻihi o nā mea ikaika - ofloxacin. Lawe ʻia ka lāʻau lāʻau 1 manawa i kēlā me kēia lā. ʻO 1 papa o Zanocin OD 400 a i ʻole 800 mg, i lawe ʻia i ka lā hoʻokahi, e hāʻawi i ka hopena therapeutic e like me ka lawe ʻana i nā papa maʻamau 2loʻoxloin 200 a me 400 mg, ma kēlā me kēia.
Hoʻomaʻamaʻa ka Zanocin ma ka ʻano papa me ke ʻano o ka nui o nā maʻi.
Aerobic gram-negative bacteria: E. coli, Klebsiella spp., Salmonella spp., Proteus spp., Shigella spp., Yersinia spp., Enterobacter spp., Morganella morganii, Providencia spp., Vibrio spp., Citrobacter spp., Serratia spp., Campylobacter spp. , Pseudomonas aeruginosa, P. cepacia, Neisseria gonorrhoeae, N. meningitidis, Haemophilus influenzae, H. ducreyi, Acinetobacter spp., Moraxella catarrhalis, Gardnerella vaginalis, Pasteurella multocida, Helicobacter pyl. Nā aho ʻokoʻa o ka lāʻau lapaʻau. ʻO ka melitensis Brucella.
Aerobic gram-positive bacteria: staphylococci, me ka penicillinase e hana nei i nā kānana, a me nā kumu lāʻau kūlia methicillin, streptococci (ka nui ʻO ka maʻi pīkoi streptococcus), Listeria monocytogenes, Corynebacterium spp.
ʻOi aku ka ikaika o Ofloxacin ma mua o ciprofloxacin e pili ana i Chachydia trachomatis. ^ E Ha yM. Hoʻoikaika pū kekahi Leprae Mycobacterium a Hoʻopiʻi i nā maʻi Mycobacterium a me kekahi mau ʻano ʻē aʻe Mycobacterium. ^ E Ha yM. Aia nā hōʻike no ka hopena synergistic o ofloxacin a me rifabutin e pili ana i M. leprae.
Treponema pallidum, nā maʻi ʻeha, nā puʻupuʻu a me nā protozoa i kuʻi ʻia ka ofloxacin.
Lapaʻau lāʻau Paʻa wikiwiki ka lāʻau a aneane paʻa i ka digestive tract. ʻO ka bioavailability piha o ofloxacin he 96% ma hope o ka lawelawe waha. Loaʻa ka paʻuhi i ke koko koko 3-4 μg / ml 1-2 mau hola ma hope o ka hoʻokele ʻana ma kahi maʻa o 400 mg. ʻAʻole e hōʻemi ʻo ka ʻai ʻana i ka inu ʻana o ka theloxacin, akā lohi i ka helu o ka absorption. ʻO ka hapalua o ka pono o ka lāʻau he 5-8 mau hola. Ma muli o kaloxacin e hoʻopiʻi nui ʻia e nā keiki, ua loli nui kona pharmacokinetics i nā mea maʻi me ka hana o ka renal impaired (cleanine clearance ≤50 ml / min) a no laila makemake lākou i kahi hoʻoponopono hoʻoponopono.
Hōʻemi ka hemodialysis i ka hoʻokaʻawale o kaloloxacin i loko o ke koko koko. Hoʻolaha nui ʻia ka Ofloxacin i loko o nā ʻili a me nā puna o ke kino, me ka CSF, ka nui o ka hoʻoili ʻana mai ka 1 a hiki i ka 2.5 l / kg. Ma kahi o 25% o ka lāʻau lapaʻau ka mea paʻa i ka protein plasma. ʻO ka Ofloxacin e hele i ka plasenta a i ka waiū umauma. Hiki ia i nā ʻike kiʻekiʻe i ka hapanui o nā kiko me nā wai o ke kino, me ka ascites, bile, saliva, bronchial secretion, gall bladder, lungs, prostate gland, bone tissue.
He Ofloxacin kahi pyridobenzoxazine ring, kahi e hoʻemi ana i ka pauku metabolic o ka pauku makua. Hoʻopau nui ʻia ka lāʻau lapaʻau i loko o ka urine i loli ʻole, me 65-80% i loko o nā hola 24-48. Kēlā i ka 5% o ka nui e kāʻei ʻia i ka urine ma ke ʻano o ka dimethyl a i nā metabolites N-oxide. ʻO 4-8% o kahi momona i lawe ʻia i loko o nā mea hoʻohua. ʻO kahi liʻiliʻi o theloxacin e hoʻopili ʻia ma ka bile.
ʻAʻohe like ʻole i ka nui o ka hoʻohele ʻana i ka lāʻau lapaʻau i loko o nā ʻelemakule, ke hōʻā ʻia nei ka lāʻau lapaʻau ʻia e nā ʻōpū ma kahi ʻano ʻole, ʻaʻohe mea i emi iki. No ka hūnā ʻia ʻo kaloxacin e nā keiki, a me nā poʻe maʻi maʻi, ʻoi aku ka nui o ka hana ʻeha o ka maʻi maʻi, ʻike ʻia ka hopena o ka lāʻau no ka hana ʻana i kahi maʻi papalapa, e like me ka mea i ʻōlelo ʻia no nā maʻi āpau.
Pharmacokinetics o Zanocin OD komo i kāna hana ʻōnaehana. ʻAʻole pili ka meaʻai i ke kiʻekiʻe o ka loaʻa ʻana o ka lāʻau lapaʻau. ʻO nā papa lōʻihi o ka papa theloxacin ka wikiwiki i hoʻopili ʻia a loaʻa iā lākou kahi kiʻekiʻe o ke kinohi ʻana i hoʻohālikelike ʻia i nā papa ofloxacin maʻamau i loaʻa mau manawa 2 i ka lā. Ma hope o ka hoʻoponopono waha ʻana a Zanocin OD 400 mg, ua hōʻea ka nui o ka nui o kaloloxacin i loko o ke koko koko ma hope o 6.778 ± 3.154 mau hola a ʻo 1.9088 g / ml ± 0.46588 μg / ml. ʻO A00—1ō ka 21.9907 ± 4.60537 μg • g / ml. Ma hope o ka lawelawe waha ʻana a Zanocin OD ma kahi o 800 mg o ka nui, ke piʻi nei ka nui o ka hōʻemi i ka lāʻai ma hope o 7.792 ± 3.0357 h ʻo ia ka 5.22 ± 1.24 μg / ml. ʻO ke kiʻekiʻe o AUC0-t ka 55.64 ± 11.72 μg • g / ml. In vitro Hoʻopaʻa ka lāʻau i nā protein plasma e ka 32%.
Ua loaʻa ka eʻinikau kūpaʻa o ka lāʻau i ka plasma koko ma hope o ka hoʻokō ʻana i ka 4-lip i ka lāʻau, a ʻo ka AUC ma kahi o 40% kiʻekiʻe aʻe ma mua o ka noi hoʻokahi.
ʻO ka hoʻopauʻana o kaloloxacin mai ke kino ka biphasic. Me ka hoʻokele waha o ka waha, ʻo ka hapalua o ka ola ka lāʻau no ka 4-5 mau hola a me 20-25 mau hola.

ʻO ka hoʻohana ʻia o ka lāʻau Zanocin

ʻAhakina: Pākuʻi ʻia ka hopena ma ke ʻano o ka microorganism a me ka paʻakikī o ka hopena, ka makahiki, ke kaumaha o ke kino a me ka hana o ke kanaka maʻi. I ka nui o nā hihia, ʻo 7 ka lā o ka mālama ʻana i nā lā he 7-10 lā, e hoʻomau ʻia ka mālama ʻana no kekahi mau lā 2-3 ma hope o ka hoʻopau ʻana o nā hōʻailona o ka maʻi. Ma nā hōʻeha koʻikoʻi a paʻakikī, hiki ke lōʻihi ke lōʻihi. ʻO ka hala o ka lāʻau lapaʻau ka 200-400 mg / lā i 2 mau puʻupuʻu i māhele ʻia. Hiki i ka wai o 400 mg (2 mau papa) ke loaʻa i ka manawa hoʻokahi, ʻoi aku ka maikaʻi ma ke kakahiaka. Hiki i ke ana hoʻokahi dosis o 400 mg no ka maʻi gonorrhea hou uncomplicated ma ke akea. Hoʻokomo ʻia ka nui o ka 400 mg e ka WHO no ka mālama ʻana i ka maʻi maʻi.
Hoʻopuka ka drip intravenous i kahi maʻa o 200 mg (100 ml) ma ka wikiwiki o 400 mg / h ma 200-400 mg 2 mau manawa i ka lā.
I ka hihia o ka hana renal hemaʻa Ua hoʻokūpaʻa ʻia ka hopena i ka nānā ʻana i ka hōʻeha o ka hana ʻole i ka renal a me ka hoʻomaʻemaʻe hana kumu. ʻO ka paipai mua o ka lāʻau lapaʻau e hōʻike ʻia ana ma ka hopena o ka hana renal impaired he 200 mg, a laila e hoʻoponopono ʻia ke ʻano me ka hoʻokaʻawale ʻana i nā hana maʻa: ma kahi hōʻailona o 50-20 ml / min - ma kahi ʻano maʻamau i kēlā me kēia 24 hola, ʻoi aku i ka 20 ml / min - 100 mg (1/2 t pono loa) i kēlā me kēia 24 hola
ʻAʻole kūkākūkā ʻia e hoʻomau i ka mālama ʻana me ka lāʻau lapaʻau ma mua o 2 mau mahina.
Zanocin OD e lawe 1 manawa i ka lā me ka ʻaina. Hoʻonohonoho ʻia ka lāʻau maʻamau i kēlā me kēia lā ma ka papaʻaina (e ʻike ma lalo) Kuhi kēia mau ʻōkuhi i nā mea maʻi me ka hana o ka renal maʻamau (clearanine clearance 50 ml / min). Pio ʻia nā papa āpau.

ʻO ka lā kala, mg

ʻO ka hoʻonāukiuki o nā mākaukau bronchitis

ʻO nā maʻi ākea o ka ʻili a me ka kiko subcutaneous

Ka urethral uncomplicated urethral a me ka gonorrhea cervical

ʻO ka cervicitis Non-neococcal / urethritis i loaʻa e C. trachomatis

ʻO nā hui a me ka cervix i hoʻoili ʻia e ka Chlamidia trachomatis a me / Neisseria gonorrhoeae

Nā maʻi maʻi o nā maʻi pelvic

ʻO ka cystitis unformpled i kumu ʻia e Escherichia coli a i ʻole ʻOi nā pneumoniae Klebsiella

ʻO kahi cystitis unclplicated i kumu o nā pathogens

1Ua hoʻokumu ʻia ke kumu kumu kumu o ka maʻi.

I ka hihia o ka hana renal hemaʻa Hoʻoponopono ʻia ka makeke inā clearance clearance ʻo ≤50 ml / min. Ma hope o ka hopena maʻamau, i ka wā e noi ai iā Zanocin OD 400 mg, ua hoʻoponopono ʻia ka ʻopālā e like me kēia:

ʻO ka mālama mālamaʻana a me ka pinepine o ka hoʻokele

No nā maʻi lēʻeha o ka ʻili a me nā palupalu palupalu, nā maʻi pulu a i ʻole ka hōʻoluʻolu o ka bronchitis palola, nā maʻi hōʻeha o nā maʻi pelvic, ua ʻōlelo ʻia e lawe i ka Zanocin OD 400 mg i kēlā me kēia mau hola 24 a hiki i kēia manawa, ʻaʻohe mau huaʻōlelo hilinaʻi i nā loli i nā dosis i ʻōlelo ʻia.

I kēia lā, ʻaʻole lawa nā ʻike e pili ana i nā loli i nā ʻōkuhi i ʻōlelo ʻia i nā mea maʻi me ka cleince clearance ≤20 ml / min.

Ke hoʻoili nei ʻo Zanocin OD 800 mg i kēia lā, ʻaʻole lawa ka ʻikepili e pili ana i nā loli i nā palena i ʻōlelo ʻia i nā poʻe maʻi me ka clearance creatinine ≤50 ml / min. Inā ʻike ʻia ka ʻike o ka creinine ma loko o ke kaila koko, hiki ke hoʻoholo ʻia e ka hoʻopiʻi mea hana.

72 (plasma hana (mg / dl))

• no nā wahine: creatinine clearance (ml / min) = 0.85 kāne clearanine clearance.

Ka loiloi ʻia o ka creatinine i loko o ke kaila koko e hoʻoholo i ke ʻano o ka hana o ka hana.
Hoʻopiʻi / cirrhosis i nā aho kūpono.
Hiki ke hoʻemi ʻia ka excretion ofloxacin i ka hoʻopiʻi ʻana i ka maʻi hepatic koʻikoʻi (cirrhosis ate me / ʻole ascites), no laila, ʻaʻole pono e hoʻonui ʻia i ka nui o ka ʻai o ka theloxacin - 400 mg i kēlā lā.
I nā maʻi maʻi maʻi ʻAʻohe mea e pono ai e hoʻoponopono i ke kū hoʻokahi, koe wale nō inā he lēʻomaʻo a i ʻole hepatic function.

ʻAtikala lāʻau lapaʻau

ʻO kahi lāʻau lapaʻau antibacterial ākea, ʻo Zanocin, i hana ʻia e ka Indian Corporation Ranbaxi Laboratories Ltd. ʻO ka hana ikaika oloxacin (ofloxacinum) e hoʻopilikia i ka DNA gyrase o nā sela o nā microorganism pathogenic, ke kāohi nei i ko lākou hiki ke hōʻuluʻulu iā lākou iho.

ʻ .lelo Ua komo loa kēia huaʻōlelo i kā mākou ola me ka paʻa loa iā mākou. "Ua loaʻa iaʻu kahi maʻi, inu i kahi paila, a holo aku nā mea a pau," manaʻo nui ka poʻe he nui. He kuhihewa hewa kēia. Hiki i nā microflora pathogenic ke luku i ko mākou kino mai loko aku a hiki i ka make. A maikaʻi paha kēia e hana inā ʻaʻole i lawe ʻia nā hana i ka manawa. Hoʻokumu ʻia kahi lāʻau antibacterial e hoʻohana ʻia ʻo Zanocin e nā hui o nā kauka a me nā mea lapaʻau i mea e pale ai i ka genome DNA o nā sela o nā flora pathogenic, e luku ana iā ia. No kēia mea, hōʻoluʻolu i ka mea hoʻomanawanui i ke kumu o kona hoʻopaʻi ʻia.ʻO ka lāʻau Zanocin e hiki ai ke hoʻopoina i nā wahi kīnā ʻole ʻino a me ka weliweli e like me nā maʻi maʻi maʻi o nā ʻano genesis.

Ke hana lāʻau lapaʻau a Zanocin

ʻO ka lāʻau lapaʻau ākea ākea e hakakā maikaʻi ʻia ana e kū'ē i nā mikrobī i ke kino o ke kanaka. Loaʻa ia i kona hopena pololei i ka gyrase enzyme o ka bacterial, kahi e hōʻoia ai i ka hoʻomau ʻana o ka maʻi bacteria. Eia kekahi, kuhikuhi nā ʻōkuhi no Zanocin e loaʻa kēia lāʻau i ka hopena bactericidal. ʻO ka hana kūʻē i nā microorganism e hoʻopuka ana i ka beta-lactamases, a me ka piʻi wikiwiki ʻana i ka myypobacteria atypical wikiwiki.

ʻO ka helu ʻana ʻo Zanocin a me ka helu ʻai palena

Hoʻonohonoho ʻia ka hoʻokele ʻana o Zanocin inā loaʻa ka maʻi maʻi i ka maʻi urinary (100 mg), nā pūpū a me nā keʻeke (100-200 mg), nā mea kanu ENT a me nā ʻaoʻao o ka lae, nā iwi a me nā ʻōpū, nā maʻi ʻeha o ka ʻili, ka loko o ka ʻōpū, nā palupalu palaleka. Eia kekahi, e like me nā loiloi, kōkua maikaʻi ʻo Zanocin i ka maʻiitisitisitis a me ka maʻi septic (200 mg). Hoʻolima ʻia ka lāʻau a ʻelua i ka lā. Hiki ke hoʻonui ʻia a hōʻemi ʻia paha ka hopena ma muli o ka paʻakikī o ka maʻi, ka hana o nā aʻoki a me nā puʻupaʻa, a me ke ʻano o nā mea o ka lāʻau.

Inā ʻike nā mea maʻi i nā hōʻaha o ka emi ʻana o ke kōkuhi, no nā kumu prophylactic, ua kuhikuhi ʻia ʻo ia e 400-600 mg no 24 mau hola.

I kekahi manawa ua mālama ʻia ʻo Zanocin i ka ʻōpio ma ka 200 mg (pono i hou ka hopena). ʻO 30 mau ka lōʻihi o ke kaʻina hana he 30 mau minuke.

Hōʻike nā ʻōlelo no Zanocin e kuhikuhi pū ʻia kēia lāʻau lapaʻau. No nā pākeke, ʻo ka nui loa ka nui o kēlā me kēia lā he 800 mg. ʻO ka lōʻihi lōʻihi o ka mālamaʻana he 1-1.5 mau pule.

ʻO ka mea maʻi me ka hana pūlū maikaʻi e pono ai e hoʻomaʻamaʻa hou aku a loaʻa i nā ʻōlelo aʻo. Hoʻomaopopo pinepine ʻia nā mea maʻi i ka hapalua i kēlā me kēia lā (100 mg). I kekahi mau manawa, lawelawe ʻia ka 200 mg no ka manawa mua, a laila hoʻomau ʻia ka papa o ka mālama ʻana me kahi maʻi o 100 mg.

I ka hihia o ka palaleka o ka ate, ʻo ka nui o kēlā me kēia lā he 100 mg (ʻoi aku ka nui o ka waiwai o kēia hihia ʻaʻole ʻoi aku ʻo 400 mg).

ʻAʻole ʻōlapa ʻia nā papa ʻaona Zanocin OD 400, holoi ʻia me kahi wai liʻiliʻi i ka wā o nā pāʻina a ma mua o ka pāʻina. ʻO ke ʻano aoao o ka mālama ʻana i ke ʻano o ka mea maʻi, a me ka lōʻihi o nā maʻi.

Nā Hoʻohui

ʻAʻole i kuhikuhi ʻia ʻo Zanocin no nā mea maʻi me ka hypersensitivity i nā mea o ka lāʻau, me ka epilepsy, ma hope o kahi hōʻeha ʻo ke poʻo, me nā hanana pānaehana o ka pūnao waena o ka pūnao, ka pīpī. Hōʻole loa ia e hoʻohana i ka lāʻau no nā keiki ma lalo o nā makahiki he 18, nā wahine hāpai, a ma ka lactation hoʻi.

Pono nā kūkākūkā hou no nā poʻe maʻi e loaʻa ʻana i ka arteriosclerosis cerebral, nā ʻōnaehana aela o ka hanana waena a me nā ulia cerebrovascular.

ʻLoe a me ke kākele

Ma ke ʻano o kahi hopena, e mālama ʻia ʻo Zanocin ma loko o loko. ʻO nā kumu a me nā hoʻohālike o ka infusion i hilinaʻi i ke ʻano a me ke kahi o ka maʻi, ka ʻeha o ka maʻi, ka makahiki o ka mea maʻi, ka hana o kona puʻuwai a me nā ʻōpū, a me ka ʻike ʻana o nā microorganisms.

Kuhi ʻia nā mea maʻi i ka 200 mg hoʻokahi a ʻelua paha i ka lā. I nā maʻi hōʻeha a paʻakikī paha, ka hoʻonui ʻia ʻana o kahi hopena a hiki i 400 mg ʻelua mau manawa i kahi lā. ʻO ka dosage nui o kēlā me kēia lā he 800 mg. ʻO ka lōʻihi o ka infusion he 30-60 mau minuke. Ma mua o ka hoʻokele ʻana, hoʻāla ʻia ʻo Zanocin me kahi hopena 5% dextrose. I ka hiki koke ʻana o ka maʻi o ka mea maʻi, ua hoʻohuli ʻia ʻo ia i ke hoʻoponopono waha ʻana i ka lāʻau ma ke ʻano o nā papa.

I loko, ua lawe ʻia ka Zanocin i ka 200-400 mg i kēlā me kēia lā. Inā ʻaʻoleʻoi aku ka nui o nā lā i kēlā me kēia lā he 400 mg, e pono ai ke lawe i ka manawa, ʻoi aku ka maikaʻi ma ke kakahiaka. Ua hoʻokaʻawale ʻia nā ʻōmua kiʻekiʻe ma nā papa ʻelua. Pono e lawe i nā paila ma mua o ka papaʻaina a i ka wā eʻai ai.

Me ka gonorrhea, ma ke ʻano he kānāwai, hoʻokahi ka pānaʻi hoʻokahi o 400 mg ofloxacin. Me ka prostatitis, 300 mg i kēlā me kēia lā ma kahi maʻamau.

I kahi hihia o ka hana renal impaired, ke hoʻemi ʻia nei ka nui o ka Zanocin:

• Inā KK he 50-20 ml / min - 100-200 mg i kēlā me kēia lā,
• Inā CC ma lalo o 20 ml / minute - 100 mg / lā.

Kuhi ʻia nā maʻi Hemodialysis e 100 mg hoʻokahi i ka lā.

Me ka hāʻule ʻole o ka ate a me ka cirrhosis, ʻaʻole pono ka nui o ka lā i kēlā me kēia lā 400.

ʻO ke kūpaʻa o ka hoʻomehana Zanocin e hilinaʻi i ka hoʻoulu ʻia o ka pathogen i ka toloxacin a me ke kiʻi kauka holoʻokoʻa. Ma ke ʻano he kānāwai, e hoʻomau ka mālama ʻana:

• No nā maʻi o ka ʻili a me ka papa hana hanu - 10 lā,
• Me nā maʻi lēpa o nā papa pelvic - 10-14 lā,
• Me ka maʻi urinary tract - 3-10 lā,
• Me ka prostatitis - a hiki i 6 wiki.

Ma hope o ka nalo ʻana o nā hōʻailona āpau o ka maʻi, ke lawe ʻia ka lāʻau lapaʻau no ka liʻiliʻi o 2 mau lā.

Hoʻolā pinepine ʻia nā papa ʻaina lōʻihi o Zanocin OD:

• Me nā maʻi o ka urinary a me nā maʻi hoʻokoe ʻia - 400 mg / lā no 3-7 mau lā, me nā maʻi paʻakikī - 10 lā,
• Me ka prostatitis - 400 mg i kēlā me kēia lā no 6 wiki,
• No nā maʻi o ka ʻili a me nā kiko palupalu, nā maʻi o ka hanu - 800 mg / lā. no nā lā 10.

Nā ʻōlelo kikoʻī

Pono ke ʻano holoʻokoʻa o ka mālama ʻana:

• E hōʻoia pono i ka hydration kūpono o ke kino,
• E nānā pinepine i kāu kaila koko
• Pōʻalo iā UV,
• E hoʻohana i ka mālama ʻana i ka wā e hoʻokuke ana i nā kaʻa a hoʻokō paha i nā hana hana pōʻino e koi ana i kahi hopena kiʻekiʻe.

Inā makemake ʻoe i ka hoʻohana lōʻihi o Zanocin, pono ʻoe e kāohi i ke kiʻi o ke koko peripheral, ʻōpū a me nā hana o ke ake.

ʻO ka emi ʻana o ka neʻe o ka maʻi oloxacin e ʻike ʻia me ka hoʻohana like ʻana o:

• nā antacids e loaʻa ai ka magnesium, calcium a me /
• Hoʻopono
• hoʻomākaukau e pili ana i nā hōʻailona hoʻokaʻawale a me nā hakakā,
• multivitamins, aia ka zinc.

No kēia kumu, aia ka liʻiliʻi o nā hola 2 no ka mālama ʻia ma waena o nā ʻano o kēia mau lāʻau lapaʻau.

Hoʻokomo pū ʻia nā NSAID me ka oflaxacin i ka hopena o ka hoʻonui ʻana i ka hopena e hoʻoikaika ai i ka ʻōnaehana sentral a me ke kūkulu ʻana i ka lalau.

Hoʻonui ʻia ka hoʻonui ʻana o ka hana me ka hoʻohana pū ʻana o Zanocin me nā aminoglycosides, nā antibiotika beta-lactam a me ka metronidazole.

Hoʻololi ʻo Ofloxacin i ka excretion theophylline, e alakaʻi ana i kahi hoʻonui o kona kukuna a me ka hoʻomohala ʻana o nā hopena pili pili.

Ashof, Zoflox, Geoflox, Oflo, Oflox, Ofloxacin, Ofloxabol, Oflomak, Oflotsid, Ofloxin, Tarivid, Taritsin, Tariferid.

ʻO nā hopena ʻaoʻao o ka lāʻau Zanocin

Ma muli o nā haʻawina haumania me ka hoʻohana pinepine ʻana o ka forloxacin, ua ʻike pinepine ʻia nā hānana: nausea (3%), ʻeha (1%), haki (1%), ʻehaʻeha (1%), huʻi (1%), hōʻeha (1%), ʻeha ʻili (1%), ka hōʻeha o ke ʻano o ke ʻano o ka wahine ma ka wahine (1%), vaginitis (1%), dysgeusia (1%).
I nā hoʻokolohua hoʻokolohua, ʻo ka hopena maʻamau loa i ʻike ʻia i ʻole ka lōʻihi o ka lāʻau lapaʻau he ala (10%), hōʻeha (9%), dysomnia (7%), hōʻeha o nā ʻōpū o ke ao wahine i ka wahine (6%), huki (5 %), vaginitis (5%), nā maʻi o ka maʻi (4%), luaʻi (4%).
Ma nā hoʻokolohua haukapila, ʻo ka hopena maʻamau loa i loaʻa i ka ʻole o ka lōʻihi o ka lāʻau a ua nānā ʻia i 1-3% o nā mea maʻi me ka ʻeha o ka ʻōpū a me ka colic, ʻeha hōʻeha, hoʻemi i ka makemake, nā lehele maloʻo, dysgeusia, luhi, ululuu, nā pilikia o ka ʻO ke kūloko o ka maʻi, ka ʻōpū, ka pharyngitis, pruritus, ke ake, ka hopohopo, ka ʻōpū, ka ʻūhā, ka ʻeha o ke kino, ka hoʻokuʻu ʻana i ka ʻōpū, ke ʻano o ka ʻike, constipation.
ʻO nā hopena ʻokoʻa i hōʻike ʻia i nā haʻawina ʻoihana ma lalo o ka 1% o nā hihia, ʻaʻohe o ka lōʻihi o ka lāʻau lapaʻau.
mau hihia laulā: asthenia, chilliness, malaise, ʻeha ma luna o nā manamana, nosebleeds,
mai ka pūnaehana cardiovascular: hopu puʻuwai, edema, hypertension, arterial hypotension, sensation o ka hoʻonui ʻana i ka puʻuwai, vasodilation,
mai ka papa gastrointestinal: ʻumiina
mai ka pae genitourinary: ka wela o ke wela, ka huhū, ʻeha a me ka wikiwiki i loko o ka wahi ʻoihana o ka wahine, dysmenorrhea, metrorrhagia,
mai ka musculoskeletal system: aripaka, myalgia,
mai ka pūnaehana neʻe o waena: nā mea hoʻokalakupua, hopohopo, hoʻōho nā hana cognitive, ke kaumaha, nā moeʻuhane maʻamau, euphoria, hallucinations, paresthesia, ʻike ʻole, vertigo, haʻalulu,
mai ka ʻaoʻao o ka pāuna: makewai, make nui,
mai ka papa hanu: hopu hopu, mare, rhinorrhea,
maʻi pālohelohe a me ke ʻano: angioedema, hyperhidrosis, urticaria, wahī, vasculitis,
mai nā kumuwaiwai naʻau: lohe pohō, tinnitus, photophobia,
mai ka urinary system: dysuria, urination pinepine, mālama ʻana i ka urinary.
Ua ʻike ʻia nā hoʻololi ʻana i nā ʻōnaehana laboratory i ≥1% o nā mea maʻi me ka hoʻohana pinepine ʻana o ka forloxacin. Hoʻopilikia ʻia kēia mau loli e ka lawe ʻana i ka lāʻau lapaʻau a me nā maʻi lalo.
mai ke kahe koko: anemia, leukopenia, leukocytosis, neutropenia, neutrophilia, stab neutrophilia, lymphocytopenia, eosinophilia, lymphocytosis, thrombocytopenia, thrombocytosis, hoʻonui ESR,
mai ka ʻōnaehana hepatobiliary: i hoʻonui hoʻonui ʻia o ka alkatine phosphatase, asat, alat,
kaukaʻi makahiki: hyperglycemia, hypoglycemia, hypercreatininemia, nui pae o ka urea, glucosuria, proteinuria, alkalinuria, hypostenuria, hematuria, pyuria.
Hoʻolaha ʻike-kūʻai
ʻO nā hopena ʻē aʻe i kūlohelohe ʻole e pili ana i ka lōʻihi o ka hoʻohana ʻana i ka lāʻau lapaʻau ua ʻike ʻia ma ke ʻano o ka noiʻi ʻana i ka noiʻi o nā quinolones, e komo pū ana me ofloxacin.
Mai ka pūnaehana cardiovascular: trombosis serebral, edema pulmonary, tachycardia, hypotension / kahalulu arterial, nāwaliwali, tachycardia ventricular e like me ka pirouette.
Mai ka ʻōnaehana endocrine a me ka metabolism: hyper-a hypoglycemia, keu i nā mea maʻi me ka maʻi maʻi e hoʻohana nei i ka maʻi insulin a i ka lāʻau hypoglycemic waha.
Mai ka palaki kuʻekuʻe: hepatonecrosis, jaundice (cholestatic a hepatocellular), hepatitis, perforation intestinal, hana hōʻeha (me nā hihia momona), colitis pseudomembranous (hōʻailona o ka pseudomembranous colitis hiki ke kū i ka wā o a ma hope o ke ʻano o ka maʻi antibiotic), ka huhū mai ka ʻeha o ka gastrointestinal, hiccups, mucous soreness iwi o ka waha waha, puʻuwai.
Mai ka pae genitourinary: vaginal candidiasis.
Mai ke koko koko: anemia (e pili pū ana i ka hemolytic a me aplastic), hemorrhage, pancytopenia, agranulocytosis, leukopenia, hoʻololi hou ʻana i ka hana o ka momona o ka iwi, thrombocytopenia, thrombocytopenic purpura, petechiae, hemorrhage subcutaneous / bruising.
Mai ka ʻōnaehana musculoskeletal: tendonitis, tendtures tendon, nāwaliwali, nānokalopoli o nā mākoi huamila.
Mai ka ʻaoʻao o ka pīkī laha waena: nā pō i ka pō, a i ʻole nā ​​hana suicidal, nā disorient, ka noʻonoʻo psychotic, paranoia, phobia, ka uha, hopohopo, ʻāwīwī / huhū, he mania, ka hana naʻauao, peropheral neuropathy, ataxia, nā koikoi luhi, hiki ke hoʻopili. pilina myasthenia a me nā maʻi extrapyramidal, dysphasia, ʻeha.
Mai ka papa hana hanu: dyspnea, bronchospasm, pneumonitis allergic, wheezing.
Hoʻopilikia a me ke ʻano o ka ʻili. Anaphylactic / anaphylactoid reaksi / pīhoihoi, purpura, maʻi serum, multimorphic erythema / Stevens-Johnson syndrome, erythema nodosum, derfitis exfoliative, hyperpigmentation, necrolysis epacoma, akamulukula, photosensitivity / phototoxicity ʻano, vesiculobulosis.
Mai nā ʻike: diplopia, nystagmus, blurred vision, dysgeusia, incaired impaired, hoʻolohe ʻana a me ka kaulike, kahi mea, ma ke ʻano he kānāwai, e hoʻoiho i ka pau ʻana o ka lāʻau lapaʻau.
Mai ka urinary system: anuria, polyuria, kalākia i loko o nā pūpū, renal gagal, interstitial nephritis, hematuria.
Nā hōʻailona kuhikuhi: ka lōʻihi o ka manawa prothrombin, acidosis, hypertriglyceridemia, hoʻonui kolamu, potasiuma, nā hana pono o ka ate, me ka gamma-glutamyltranspeptidase, LDH, bilirubin, albuminuria, candiduria.
I nā hoʻokolohua lapaʻau me ka hoʻohana pinepine ʻana i nā quinolones, ua ʻike ʻia nā maʻi ophthalmic, e komo ana me ka cataract a me ka pinpoint opacification o ka lens. ʻAʻole pili i ka pilina o ka lawe ʻana i ka lāʻau lapaʻau a me ke ʻano o kēia mau maʻi.
ʻO ka hopena o ke crystalluria a me cylindruria i hōʻike ʻia me ka hoʻohana ʻia o nā quinolones.

Nā ʻAina Kauka Zanocin

Antacids, sucralfate, cation metal, multivitamins. ^ E Ha yM. Hoʻokomo ʻia nā quinolones i nā hoʻopili hoʻopiʻi me nā mea alkaline a me nā mea lawe aku i nā mea hao metala. ʻO ka hoʻohana ʻana o ka quinolones i hui pū me ka hoʻomākaukau antacid e loaʻa ana i ka calcium, magnesium a i alumini, sucralfate, divalent a trivalent cations (hao wale nō), hoʻomākaukau ʻana a multivitamin e loaʻa ana i ka zinc, didanosine hiki ke hōʻemi nui i ka hoʻopili ʻana o nā quinolones, a laila hoʻemi ʻia kā lākou kukuna systemic. Lawe ʻia nā lāʻau i luna ma 2 mau hola a i ʻole a ma hope o ka lawe ʻana o theloxacin.
Kāleka ʻAʻohe mea ʻike i ʻike.
Nā Cyclosporins. ^ E Ha yM. ʻAʻole i hōʻike ʻia kahi e hoʻonui ai i ke kiʻekiʻe o ka cyclosporine i loko o ke koko koko i ka wā e hui pū ʻia me nā quinolones. ʻAʻole i aʻo ʻia ka pilina loa ma waena o quinolones a me nā cyclosporins.
ʻO Cimetidine kumu i kahi uhai o ka hoʻopau ʻana o kekahi mau quinolones, ʻo ia hoʻi ka mea i piʻi ai i ka hapalua o nā hapa o ka lāʻau lapaʻau a me AUC. ʻAʻole i aʻo ʻia ka pilina ma waena o kaloloxacin a me cimetidine.
ʻO nā lāʻau i hoʻoneʻeneʻe e ka cytochrome P450 ene. ^ E Ha yM. ʻO ka hapa nui o ka hoʻomākaukau ʻana quinolone e kālai i ka hana o ka enzymatic o ka cytochrome P450. Hiki i kēia ke alakaʻi i ka lōʻihi o ka hapalua-ola o nā lāʻau e hoʻohālikelike ʻia e ka pūnaehana like (cyclosporine, theophylline / methylxanthines, warfarin) i ka wā e hui pū ai me ka quinolones.
Nā NSAID. ʻO ka hui pū ʻana o nā NSAIDs a me nā quinolones, me kaloloxacin, hiki ke alakaʻi i ka nui hoʻonui ʻana o ka hopena e hoʻonāukiuki i ka pūnaehana ʻōnaehana waena a me nā kahakui.
Probenecid. ^ E Ha yM. ʻO ka hoʻohana pū ʻana o ka probenecid a me nā quinolones e pili ana i ka excr tubular excretion. ʻAʻole i aʻo ʻia ka hopena o ka probenecid ma ka onloxacin excretion.
Theophylline. ʻO nā pae theophylline kiʻekiʻe e hoʻonui paha i ka hui pū ʻana me kaloloxacin. E like me nā quinolones, hiki i ka ofloxacin ke hoʻolōʻihi i ka hapalua o ke ola o theophylline, e hoʻonui i nā pae o ka plasma o ka theophylline a me ka hopena o ka hopena o ka hopena o ka theophylline. Pono e hoʻoholo pinepine i ka pae o ka theophylline i loko o ke koko koko a hoʻoponopono i ka maʻi maʻamau ia i ka wā e lawelawe ʻia ai me ka ofloxacin. Hiki i nā hopena ʻaoʻao (me nā kuʻuna) me ka ʻole me ke piʻi ʻana o nā pae theophylline i loko o ke koko koko.
Warfarin. Hiki paha i kekahi quinolones ke hoʻomaikaʻi i nā hopena o ka hoʻopuka waha i ka warfarin a i nā mea waiwai paha. No laila, me ka hoʻohana pū ʻana o nā quinolones a me warfarin a i ʻole kona mea e pili ana, ka manawa prothrombin a me nā hōʻailona ʻē aʻe o ke kōkoʻe koko.
ʻO nā hui antidiabetic (insulin, glyburide / glibenclamide). ^ E Ha yM. Ua hōʻike ʻia he hoʻololi i ka glucose o ke koko, me ka hyper- a me hypoglycemia, ʻoiai e lawe ana i ka lāʻau quinolone a me nā lāʻau antidiabetic, no laila, e nānā mau ʻia ka glycemia me ka hoʻohana pū ʻana o nā lāʻau o luna.
Ke hōʻike nei i ka hopena e pili ana i ka renal tubcr excretion (furosemide, methotrexate). Me ka hoʻokolohua ʻōhumu o ka quinolones a me nā lāʻau hōʻona e pili ana i ka excr tubular excretion, hiki i ka hewa ke kāpae i ka excretion a me ka hoʻonui ʻana ma ka pae o ka quinolones i loko o ke kaila koko.
Pilikia nā hoʻokolohua aiʻole i nā maʻi diagnostic. ^ E Ha yM. ʻO kekahi quinolones, me ka loaʻa o kaloloxacin, hiki ke hāʻawi i nā hopena maikaʻi ʻole no ka hoʻoholo ʻana o nā opiates i ka urine me ka hoʻokūkū waha o nā mea maʻi immunological.
ʻO ka ʻike ʻole o ka ʻikepili i ka hiki o ka hoʻonā me nā hopena infusion a me kahi hoʻomākaukau ʻē aʻe o Zanocin i ke ʻano o ka hopena no ka infusion, pono e hoʻohana kūʻokoʻa. Pili ka lāʻau i ka isotonic sodium chloride solution, ka pane ʻana o ka mea hoʻokele, 5% glucose a i ʻole ka hopena fructose.