Nā ʻōkuhi no ka hoʻohana ʻana i ka lāʻau Telsartan a me nā loiloi e pili ana iā ia

No Nā Diabetes "Pehea e hoʻohana ai iā Telsartan 40?

ʻO ka nui o nā lāʻau lapaʻau e hoʻemi pono ana i ke kahe o ke koko a mālama iā ia i kahi pae kiʻekiʻe loa e pili ana iā Telsartan 40 mg. Hoʻohana ʻia o ka lāʻau lapaʻau: lawe i 1 papa i kēlā me kēia lā, lōʻihi ka hopena o ka hopena antihypertensive, ʻaʻohe hopena o ka puʻuwai puʻuwai. Nā mea hōʻike o ke systolic a me diastolic blood pressure e like me ka hoʻohaʻahaʻa nui ʻana ma hope o hoʻokahi mahina o ka hana maʻamau.

• 8.10 mai ka palu paleka a me ka pihi biliary
• 8.11 Alehu
• 8.12 Ka hopena i ka hiki ke kāohi i nā mīkini

E hoʻokuʻu i nā palapala a me ka ʻano

ʻO ka lāʻau lapaʻau he papa papa ʻulaʻula ʻole me ka ʻole o ka pale, convex ma nā ʻaoʻao ʻelua. Ma ka ʻaoʻao ma luna o kēlā me kēia mea i loaʻa ka pilikia no ka maʻalahi o ka haki ʻana a me nā leka "T", "L", i ka ʻaoʻao i lalo - ka helu "40". I loko, hiki iā ʻoe ke ʻike i nā wahī 2: kahi pinkish i loko o ke kala o nā mea hoʻoikaika ʻole, ʻē aʻe kekahi i keʻokeʻo, i kekahi manawa me nā inclusions liʻiliʻi.

I ka papa papaʻa o kahi hui pūʻokoʻa - 40 mg o ka papa hana nui o ka telmisartan a me 12.5 mg o ka diuretic hydrochlorothiazide.

Hoʻohana ʻia nā mea kōkua.

• mannitol
• lactose (waiū waiu),
• povidone
• Nā meglumine
• konekena stearate,
• sodium hydroxide
• 803
• poloka E172.

I ka papa papaʻa o kahi hui pūʻokoʻa - 40 mg o ka papa hana nui o ka telmisartan a me 12.5 mg o ka diuretic hydrochlorothiazide.

Nā Papa o 6, 7 a i ʻole 10 mau kamepiula. hoʻokomo ʻia i loko o nā blisters i hoʻokumu ʻia i ka alumini foil a me ka kiʻi polū. Hoʻopili ʻia i nā pahu pahu pepa 2, 3 a 4 paha mau leta.

Ka hana lāʻau lapaʻau

ʻO ka lāʻau lapaʻau e hana i kahi hopena pālua ʻelua: hypotensive a me diuretic. ʻOiai ʻo ka like ʻana o ka kemana o ka mea nui o ka lāʻau lapaʻau e like me ke ʻano o ka angiotensin type 2, ka neʻe ʻana o ka telmisartan i kēia hormone mai ka pilina me nā mea inu koko a me nā poloka i kāna hana no ka wā lōʻihi.

I ka manawa like, pale ʻia ka hana o ka aldosterone manuahi, e kāpae ana i ka paʻakai mai ke kino a mālama i ka sodium, e hāʻawi ana i ka hoʻonui o nā leo vascular. I ka manawa like, ʻo ka hana a renin, he enzyme e hoʻoponopono ana i ke koko, ʻaʻole paʻa. ʻO ke hopena, e pau ka piʻi ʻana o ke koko, e hōʻemi nui ʻia kona hoʻohaʻahaʻa nui.

Ma hope o ka 1.5-2 mau hola ma hope o ka lawe ʻana i ka lāʻau, hoʻomaka ka hydrochlorothiazide e hoʻokō i kona hopena. ʻO ka lōʻihi o ka hana o ka diuretic ka mea like i 6 a 12 mau hola. I ka manawa like, ua emi ka nui o ka neʻe o ke koko, ka hoʻonui ʻana o ka ald testosterone, hoʻonui i ka hana renin.

ʻO ka hopena hoʻohui o ka telmisartan a me ka diuretic e hana i ka hopena antihypertensive ʻoi aku ka hopena ma mua o ka hopena i nā moku o kēlā me kēia. I ka wā o ka mālama ʻana me ka lāʻau lapaʻau, hōʻemi ʻia nā hōʻike o myocardial hypertrophy, hoʻemi ʻia ka make, ʻoi aku hoʻi i nā mea maʻi ma mua o nā maʻi me ka puʻuwai kiʻekiʻe.

I ka wā o ka mālama ʻana me ka lāʻau lapaʻau, hōʻemi ʻia nā hōʻike o myocardial hypertrophy.

ʻO ka hui pū ʻana o ka telmisartan me hydrochlorothiazide ʻaʻole e loli i ka pharmacokinetics o nā mea. ʻO kā lākou huakaʻi holoʻokoʻa he 40-60%. Hoʻopili koke ʻia nā mea ikaika o ka lāʻau mai ka digestive tract. ʻO ka pae kiʻekiʻe loa o ka telmisartan hōʻiliʻili i loko o ke koko koko ma hope o 1-1,5 mau hola he 2-3 mau manawa haʻahaʻa i lalo o nā kāne ma mua o nā wahine. Hoʻokomo ka hoʻokaʻawale ʻaoʻao i nā pepi, hoʻoneʻe ʻia kēia mea waiwai i nā moʻo. Hoʻokuʻu ʻia ka Hydrochlorothiazide mai ke kino a aneane i loli ʻole me ka urine.

Nā hōʻailona no ka hoʻohana ʻana

• ma ka mālama ʻana i ka hypertension mua a me ka lua, inā ʻo ka mālama ʻana me ka telmisartan a i ʻole hydrochlorothiazide ʻo ia wale nō e hāʻawi i ka hopena i makemake ʻia,
• i mea e pale ai i nā hoʻopiʻi o nā maʻi cardiovascular koʻikoʻi ma ka poʻe i ʻoi aku ma mua o 55-60 mau makahiki,
• i ka mea e pale ai i nā hoʻopiʻi i nā maʻi me ka maʻi II II (non-insulin-dependant) me ka ʻeha kino i hoʻoneʻe ʻia e ka maʻi lalo.

Nā Hoʻohui

ʻO nā kumu no ka pāpā ʻana i ka mālama ʻana me Telsartan:

• hypersensitivity i nā mea ikaika o ka lāʻau,
• maʻi maʻi koʻikoʻi
• ka lawe ʻana iā Aliskiren i nā maʻi me ka hōʻoki ole o ka maʻi, diabetes,
• decompensated paleka holo ole,
• bile pauku
• lactase nele, lactose intolerance,
• huhū,
• hypokalemia
• hapai a lactation
• keiki malalo o 18 makahiki.

Pono e mālama mua ʻia i nā maʻi a i ʻole nā ​​hopena pathological i loaʻa i nā maʻi:

• emi i ke kahe o ke koko,
• nā puʻuwai o nā renal, nā puʻuwai o ka puʻuwai,
• hōʻeha paʻa ka naʻau
• malie palupalu pale,
• maʻi maʻi
• kohola
• adrenal cortical adenoma,
• koki-kikina glaucoma,
• lupus erythematosus.

Pehea e lawe ai iā Telsartan 40

Lapa ʻaʻai maʻamau: ka waha o kēlā me kēia waha ma mua o a ma hope o ka ʻai ʻana, 1 papa, pono e holoi ʻia me ka liʻiliʻi o ka wai. ʻO ka lōʻihi loa o kēlā me kēia lā no nā ʻano koʻikoʻi o ka maʻi hypertension a hiki i ka 160 mg. Pono e hali i ka noʻonoʻo: ʻaʻole ka hopena koke o ka hopena therapeutic, akā ma hope o 1-2 mau mahina o ka hoʻohana ʻana i ka lāʻau.

Lapa ʻaʻai maʻamau: ka waha o kēlā me kēia waha ma mua o a ma hope o ka ʻai ʻana, 1 papa, pono e holoi ʻia me ka liʻiliʻi o ka wai.

ʻO nā poʻe maʻi me kēia maʻi e kuhikuhi pinepine ʻia i ka pale ʻana i nā hōʻeha mai ka puʻuwai, pūpū, a me nā maka. No nā maʻi he nui me ka maʻi maʻi hypertension, ua hōʻike ʻia kahi hui o Telsartan me Amlodipine. I kekahi mau manawa, piʻi ka nui o ka waikika uric i ke koko, piʻi nui ka gout. ʻElua paha e hoʻoponopono i ka lāʻau lapaʻau o ka lāʻau hypoglycemic.

Nā hopena hopena o Telsartan 40

ʻO nā helu o nā hopena maikaʻiʻole i kēia lāʻau lapaʻau a me ka telmisartan i lawe ʻia ʻole me ka hydrochlorothiazide e like like me ia. ʻO ka maʻamau o nā hopena he nui, no ka laʻana, nā pilikia o ka trophism kiko, metabolism (hypokalemia, hyponatremia, hyperuricemia), ʻaʻole pili i ka dosage, ka uka a me nā makahiki o nā mea maʻi.

Hiki i kahi lāʻau lapaʻau i nā hihia līkī ke hōʻeha:

• ka malo maloʻo
• ʻumiina
• he ʻano hūnā
• ʻeha ka ʻōpū
• constipation
• nā ninia
• utuka
• gaugitis.

Hiki i nā mea hoihoi i ka lāʻau lapaʻau ke komo pū paha:

• hōʻemi i ka pae o hemoglobin,
• anemia
• eosinophilia
• thrombocytopenia.

ʻO ka hopena ʻaoʻao pinepine ka hoʻonāukiuki. Loaʻa pinepine ia:

• paresthesia (sensations o nā creos goosebumps, tingling, ʻāʻā i nā ʻeha),
• ka ʻūhā ʻole e ae, ka hiamoe,
• ʻike ʻike blurry
• nā kūlana hopohopo
• manaʻo ʻino
• hoʻōlohelohe (hina nāohi kokoke), nāwaliwali.

• mahuahua o ka uric acid, Mea hana i loko o ke koko koko,
• ka hana o ka hoʻonui ʻana o ka hoʻonaninani CPK (creatine phosphokinase),
• huehae huehal i pau
• urinary tract maʻi, including pūnana cystitis.

Nā manaʻo ʻino hou ʻole:

• ʻeha ka naʻau
• ʻaʻano pōkole
• flu-like syndrome, sinusitis, pharyngitis, bronchitis,
• nā maʻi pīpī, polema pulmonary.

• ka erythema (ʻulaʻula nui o ka ʻili),
• ka māla ʻana
• ʻohiʻala
• huu
• hoʻonui nui loa
• urticaria
• dermatitis
• eczema
• angioedema (loaʻa iki ʻole).

ʻAʻole hoʻopilikia ʻo Telsartan i ka hana o ka māhele ʻano.

• aʻai a i ʻole orthostatic hypotension,
• keleula, tachycardia.

ʻO ka hopena ʻae ʻia e pili ana i ka ʻōnaehana musculoskeletal i hiki.

• ʻeha, hōʻeha nei i nā ʻōpū, nā tendons, na hui pū,
• nā ʻōpala, pinepine i nā ʻōpū o lalo,
• lumbalgia (maʻi hōʻeha ma ka kua o hope).

Ma lalo o ka hopena o ka lāʻau i nā hihia ʻehā, hiki ke ʻike ʻia nā mea aʻe:

• nā mea hoʻonui i loko o ka pūpuna,
• hoʻonui ka hana o nā enzymes i hana ʻia e ke kino.

Loaʻa pinepineʻole ka pīhoihoi anaphylactic.

Ma muli o ka loaʻa ʻana o ka puʻuwai, ʻaʻole hiki ke hoʻonā ʻia ka dizzness, e ʻōlelo ʻia ka mālama ʻana i ka wā e lawe ana i kahi kaʻa, e hana ana i nā hana e koi nui loa.

Nā ʻōlelo kikoʻī

Me ka nele o ka sodium i loko o ka plasma a i ʻole ka lawa o ka nui o ke koko lele, hiki i ka hoʻomaka ʻana o ka lāʻau lapaʻau me ke ʻano o ka hoʻolilo ʻana i ke koko. Hoʻokomo pinepine ka hypotension ene i ka poʻe maʻi me ka stenosis valula, maʻi i ka coronary puʻuwai, a me ka pohō o ka naʻau. Hiki i kahi hāʻule hōʻeha ma ke koʻikoʻi ke alakaʻi i kahi hōʻeha a i ʻole ka myocardial infarction.

E hoʻohana i ka lāʻau lapaʻau me ka mālama a me ka stenosis o ka mve a i ʻole ka aicic valve.

I nā maʻi maʻi, hiki i nā hōʻeha hypoglycemia. Pono e nānā pinepine i ka pae o ka glucose i ke koko, e hoʻoponopono i ka nui o nā ʻaole o hypoglycemic.

I nā maʻi maʻi, hiki i nā hōʻeha hypoglycemia.

Hiki i ka Hydrochlorothiazide mahele o Telsartan ke hoʻonui i ka hoʻoili ʻana o nā mea momona o nā mea momona o ka pona i ka hopena o ka hana renal impaired, a me ke kumu o ka hoʻomōlala ʻana i ka mana myopia, angle-closure glaucoma.

Hoʻohana pinepine ka hoʻohana ʻana i ka lāʻau i ka hyperkalemia. Pono ia e nānā i nā kiko o nā electrolytes i nā kaila koko.

Ke hoʻopiʻi ʻole ʻia nei kahi hopena o ka lāʻau ke alakaʻi i ka hoʻolālā ʻana o ka haʻalele.

Me ka hyperaldosteronism maʻamau, ʻaʻole pilikino ka hopena therapeutic o Telsartan.

Contraindicated ka lapaʻau ʻana i ka wā gestation a me ka umauma.

ʻAʻole noʻonoʻo ka lāʻau lapaʻau e hoʻohana ʻia e nā mea maʻi ma lalo o ka 18 mau makahiki o ka makahiki.

I ka loaʻa ʻole o nā maʻi concomitant koʻikoʻi, ʻaʻohe pono no ka hoʻoponopono hoʻoponopono ʻia.

ʻAʻole pono ke hoʻoponopono ʻia ʻo ka Doseage no nā mea maʻi me ka hiki ʻole o ka renal ke ʻano o ka hōʻeha ʻana, ʻo ia hoʻi e hana ana i nā kaʻina hemodialysis.

Wahi a nā hopena o nā haʻawina he nui i nā poʻe maʻi me ka hana maʻalahi o ka naʻau i ʻole ka maʻi o ka lā, ʻaʻole nui ka lāʻau o kēlā me kēia lā i ka 40 mg.

Wahi a nā hopena o nā haʻawina he nui i nā poʻe maʻi me ka hana maʻalahi o ka naʻau i ʻole ka maʻi o ka lā, ʻaʻole nui ka lāʻau o kēlā me kēia lā i ka 40 mg.

Hoʻopili pū me nā lāʻau ʻē aʻe

Me ka hoʻohana like pū me nā lāʻau ʻē aʻe e hōʻemi ai i ke koko, e hoʻonui ka lāʻau lapaʻau i ko lākou hopena therapeutic.

Ke lawe nei ʻo Telsartan me Digoxin, ke piʻi nui ka luhi o ka glycoside cardiac, no laila, pono ke nānā aku i nā pae serum.

I mea e pale aku ai i ka hyperkalemia, ʻaʻole pono e hui pū ʻia ka lāʻau me nā mea hoʻomo e loaʻa ana i ka potassium.

Ka mālama ʻohi ʻana i ka ʻike o ka lithium i ke koko aʻo ke hoʻohana ʻana i nā lāʻau lapaʻau e pili ana i nā mea hoʻohui o kēia metala alkali, no ka mea hoʻonui ka telmisartan i ko lākou hōʻalo.

ʻO Glucocorticosteroids, Aspirin a me nā mea hoʻohana non-steroidal anti-inflammatory ke hōʻemi nei i ka hopena antihypertensive o ka lāʻau.

Hoʻokomo ʻia nā NSAID me ka telmisartan i ka hana ʻole ʻana i ka hana.

I ka wa me ka lāʻau lapaʻau, pono ʻoe e inu i ka wai ʻaka o kekahi ʻano.

Hiki ke hoʻololi ʻia a Telsartan me nā lāʻau lapaʻau e like me ka hopena like:

Nā Hōʻikeʻike iā Telsartan 40

Maria, 47 makahiki, Vologda

ʻO nā paila he nui a he mea palekana i ka nui o nā mālama no ke maʻi vascular. He mea kupaianaha wale nō hoʻi ʻia kēlā lāʻau lapaʻau maikaʻi ma India, ʻaʻole iā Kelemania a me Switzerland paha. Ua liʻiliʻi nā hopena ʻaoʻao. ʻO kekahi mau manawa ke hoʻopilikia wale nei i ka palupalu iaʻu, akā ua hōʻeha mai iaʻu no ka manawa lōʻihi inā ʻaʻole wau i lawe iā Telsartan.

Vyacheslav, 58 makahiki, Smolensk

Ua lōʻihi wau i ka hypertension. Hoʻokomo hou ʻia kahi papalole wahine. ʻO nā mākaukau hoʻokahi wale nō ʻaʻole i lawe ʻia no nā makahiki he nui i ka mālama ʻana! Akā pono ka hoʻololi ʻia, no ka mea hoʻohana ke kino iā ia, a laila pau lākou i ka hana e like me ka wā ma mua. Ua hala wau i ka lawe ʻana iā Telsartan. Hāʻawi ke aʻo iā ia i kahi papa inoa loa o nā hopena ʻaoʻao, akā ʻaʻole i kū kekahi. ʻO ka lāʻau maikaʻi e paʻa ai i ka paipai. He liʻiliʻi iki ka ʻoiaʻiʻo.

Irina, 52 makahiki, Yekaterinburg

No ka manawa mua, ʻōlelo ʻo ka mea lapaʻau i pono e lawe ʻia ʻo ʻAlodipine, akā ma hope o hoʻokahi pule ua hoʻomaka kona mau wāwae. Ua hoʻololi ʻo ke kauka iā ia me Enap - ʻaʻole hoʻomaka koke kahi huhū e nahā iaʻu. A laila, pono wau e hoʻololi iā Telsartan, akā ua huli wau i ka pilikino pilikino iā ia. Aia ka maʻi iki, a laila puka maila ka pelu kino. Hele hou wau i ka hauka. A wale wale nō ke kuhikuhi nei ka mea lapaʻau i nā mea āpau i hāʻule i nā wahi āpau. ʻAʻohe pilikia i kēia mau pōpoki. No laila he mea koʻikoʻi loa ia e koho i ke kauka i ka lāʻau kūpono no ʻoe.

ʻO ka ʻike nui o ka lāʻau lapaʻau

ʻO nā hana a ka lāʻau lapaʻau e pili pū ana me ka hoʻohaʻahaʻa ʻana i ke koko, akā e like me ka hōʻemi ʻana i ka luhi ma ka puʻuwai, ka pale ʻana o nā ʻōpala kūpono (retina, vascular endothelium, myocardium, ʻōpio, ʻōpio), ke pale aku i nā hoʻopiʻi (hōʻeha o ka naʻau, ka hōʻeha), a me nā mea ʻē aʻe ka heleʻana o nā kumuwaiwai hou aku (ʻoi ʻia ka ʻike koko, maʻi mellitus).

Hōʻemi ʻo Telsartan i ka pale ʻana i ka insulin, hoʻonui i ka hoʻohana ʻana i ka glucose, hoʻoponopono ʻia i ka dyslipidemia (hōʻemi i ka nui o ka LDL "hōʻino" a hoʻonui i ka "pono" HDL).

Nā lāʻau lapaʻau, INN, the scope

ʻO Telsartan kahi mea koho blocker ala-kaiotensin-II (AT1). ʻO Telsartan N - no nā lāʻau hui hoʻohui, e hoʻohui i ka pā o ka ʻāpana ʻāmaʻomaʻi o ka angiotensin-II (AT1) me ka hana nui a me ka hopena antidiuretic o ka hydrochlorothiazide. Ma ke ʻano kemikū, nona ka biphenyl netetrazole compound. He lāʻau hana ikaika ia. He hui hoʻokūkū hoʻokūkū ʻole e hoʻopaʻa ana i nā receptors me ka hoʻohuli.

ʻO ka hopena o ka antagonist reseptor angiotensin II

INN: Telmisartan / Telmisartan. Hoʻohana ʻia i ka cardiology ma ka hakakā me ka piʻi ʻana o ka systolic a me ka diastolic pressure, hōʻemi ʻole ka naʻau. Hoʻohana ʻia ʻo Telsartan N no ka hiki ʻole o ka monotherapy me nā lāʻau lapaʻau o nā hui ʻē aʻe.

Puka o ka hoʻokuʻu a me nā kumukūʻai no ka lāʻau lapaʻau, ka awelika ma Lūkia

Hoʻohana ʻia ka lāʻau lapaʻau i loko o ke ʻano he papa papa, ma ʻelua mau kaha - 40 a 80 mg. I kahi pahu pahu pahu 3 polō o nā papa papa he 10. He pākana i ka ʻaoʻao o ka papa, he convex ma nā ʻaoʻao ʻelua, ʻaʻohe ʻiole, ʻōmaʻomaʻo hoʻi ma ka ʻoni, me nā laina ma ke kikowaena ma kekahi ʻaoʻao, ma nā ʻaoʻao ʻelua mau ʻano embossments - "T and L", hōʻike ʻia ka dosage ma ka ʻaoʻao ʻaoʻao.

Hōʻike ka papa ma lalo nei i ke kumukūʻai i nā rubles no nā lāʻau lapaʻau:

Hōʻike ka papa i nā mea nui o ka lāʻau lapaʻau:

Pharmacodynamics a me ka pharmacokinetics

ʻO Telsartan kahi hua koho 1 angiotensin-II inhibitor inhibitor. Aia kēia mau ʻāpono i nā kiko o ke kino, ka mahele nui o nā ʻalohi o nā moku, myocardium, cortical layer o nā uʻi adrenal, māmā, a me kekahi mau wahi o ka lolo. ʻO Angiotensin-II ka maikaʻi loa o ka peptide effector peptide o ka renin-angiotensin-aldosterone system (RAAS).

Ma o nā mea nānā aku o kēia ʻano, ʻike ʻia nā hopena e kū pololei a i ʻole kekahi me ka nui o ka nui o ka neʻe o ke koko, akā pinepine ka manawa. Hōʻalo ka hana a Telsartan i ko lākou hōʻemi, ʻo ia hoʻi, ua ālai ʻia a pale ʻia paha:

• ka hoʻonui ʻana o ka huina pale ākea o nā mākele o nā ʻokoʻa o ka caliber,
• ʻO ka vasoconstriction o nā kīʻaha koko o nā glomeruli o nā pūpū a hoʻonui i ke kaomi hydraulic i loko o lākou,
• ka mālama ʻana i ke kino o ka nui o ka wai o ka nui: ka hoʻonui ʻia ʻana o ka sodium a me ka wai i loko o nā poli, ʻo ka hana ʻana o ka ald testosterone,
• ka hoʻokuʻu a me ka hormone antidiuretic, endothelin-1, renin,
• ka hoʻomohala ʻana o ka ʻōnaehana apu-adrenal a me ka hoʻokuʻu ʻana o catecholamines ma muli o ke komo ʻana i ka punawai koko-lolo.

Hoʻopili i nā RAAS systemic, aia pū kekahi pūnao (local local system RAA) i nā ʻano kikoʻī a me nā kino. ʻO kā lākou hāmeʻa hiki ke hana i ka hopena lōʻihi o ka angiotensin, e alakaʻi ai i ka hoʻopulapula o ka hopena o ka endothelium a me ka hoʻōla ʻana o nā kīʻaha koko, cardiomyocyte hypertrophy, myocardial remodeling, myofibrosis, atherosclerotic vascular damage, nephropathy, a me nā pōʻino o ka hui.

ʻO kahi hiʻohiʻona o Telsartan e pili pono ana ia paʻa i ka ʻano mua o ka ʻoni o ka angiotensin-II no ka manawa lōʻihi a hoʻopau loa i ka hopena maikaʻi o ka angiotensin, "ʻaʻole waiho ʻia" ia i ka poʻe ʻāpono.

Hana ka hana mai 24 a 48 mau hola. ʻO ka emi o ke kahe o ke koko e hele pololei ana, me ka palau loa i nā hola. Hoʻohālikelike ʻia me nā mea hoʻopaʻa ACE like, ʻo ia ka mea i manaʻo ʻia ʻo kekahi o nā pūʻulu maikaʻi loa o nā lāʻau antihypertensive, ʻo kēia mau ʻōpiopio ka mea maikaʻi loa o ka lāʻau lapaʻau.

• pani piha ʻana i ka hopena maikaʻi loa o ka angiotensin (ʻaʻole paʻa i paʻa ʻia nā pale o ACE),
• ka ʻike ʻana i ka hopena maikaʻi o ka angiotensin ma o nā mea mālama aku o ka ʻano AT2 (ʻaee ACE, ma ke ʻano, hoʻēmi)
• ʻaʻole i pale i ka kinase, ma muli o ke ʻano o ka hopena ʻole i ka bradykinin a, ma muli o kēia, ke ʻano hoʻopiʻi e pili ana me ia (ʻo ka u, ka angioedema, ka hopena embiotoxic, hoʻonui i ka syntacyclin synthesis).
• hui pūpū.

Loaʻa nā mea ʻike o ke ʻano lua ke ʻike ʻepekema, akā ua hiki i nā kānaka ʻepekema ke hoʻokumu he nui o lākou i ka manawa embryonic, e hōʻike ana i ko lākou hopena ma ka ulu o ke kō a me ka ʻokiʻoki. Ma hope mai, ua emi iho ko lākou helu. ʻO ka hana ma o kēia mau mea nānā e kū'ē i ka hana a nā mea mua i manaʻo. Loaʻa ka hopena maikaʻi ma o nā ʻae ʻĀpī AT2:

• hoʻoponopono kūwaho i ka pae o ka cellular,
• vasodilation, hoʻonui synt synt o NO-factor,
• hoʻomaloʻo i ka ulu o ka cell, proliferation,
• hoʻopaʻaʻana mai i ka hypertrophy cardiac.

ʻO ka Telsartan H kahi hopena antihypertensive ikaika loa, aia ka hydrochlorothiazide - kahi diuretic loop e hōʻemi ana i ka reabsorption o ka sodium ion a me ka wai e nā keiki, e hoʻolako ana i kahi hopena antidiuretic. Hāʻawi ia i ka maʻalahi o ka hoʻohana ʻana: ma kahi o nā papa he nui, lawa ia e lawe hoʻokahi manawa i kēlā me kēia 24 hola, kahi e hāʻawi ai i ka hopena hui maikaʻi.

Me ka hoʻohana pinepine ʻana, ka hopena therapeutic o ka telmisartan e pili ana i kahi o 3-5-7 mau pule. Hoʻopau like ia i ka hoʻohaʻahaʻa sstolic a me ka diastolic. ʻAʻohe mea i haʻalele i ka maʻi ʻaihue: i ka wā e hoʻōki ai i ka lawe ʻana i ka lāʻau, hoʻihoʻi ka piʻi ʻana i nā helu nui no kekahi mau lā, ʻaʻohe ʻano kīwī hāhā i kū ʻoe.

I ka lawe ʻana i kēlā me kēia os, ʻike ʻia ka nui o ka nui o ke koko ma hope o 1-2 mau hola. ʻO Bioavailability 60%, hoʻouka koke ʻia. Hiki i ka lāʻau lapaʻau ke lawe i kēlā me kēia manawa, me ka mālama o ka meaʻai. 98.6% a i oi paha nā mea e hoʻopili ai i ka protein o ka plasma, hoʻopili hou ʻia i nā kiko (hoʻoliili ka lahilahi e pili ana i 510 l).

Ua kiʻekiʻe ke koʻikoʻi o ke koko o nā wahine ma mua o nā kāne, ʻaʻole pili kēia i ka kūpono. Ma kahi o 98% o telmisartan ua hoʻopuka ʻia ma o ka system biliary, kahi liʻiliʻi - me nā urine. Hoʻomili ʻia ia e ka conjugation, ka hopena i ka hoʻokumu ʻana o acetylglucoronide i kahi ʻano hana ʻole ʻole. ʻO ka huakaʻi o ka huakaʻi heʻoi aku ma mua o 1499 ml / min. ʻO ka hoʻopau hapa hapa-ola e ʻoi aku ma mua o 19 mau hola. ʻAʻole i hoʻohālikelike ʻia ka Hydrochlorothiazide a hoʻopiʻi ʻia i loko o kāna ʻano manuahi me ka urine.

ʻAʻole loli ʻo Pharmacokinetics e pili ana i ka wahine a me ka makahiki. I ka poʻe maʻi me ka hana ʻole o ka ʻōnaehana excretory, ʻo ke kaʻi ʻana i ke koko i nā manawa he nui i ʻoi aku ma mua o ka mea maʻamau, me ka hemodialysis, ma kahi ʻē aʻe, hoʻohaʻahaʻa hoʻi, ʻoiai ke pili pū me ka maikaʻi o ka mea hana me nā protein koko. I kahi hihia o ka hepatic function, hoʻonui ka bioavailability i ka 98%.

Nā hōʻailona a me nā contraindications

ʻO nā hōʻailona nui no ka hoʻohana ʻana o Telsartan:

• koko koko kiʻekiʻe
• ka pale ʻana o nā maʻi a me nā maʻi vascular,
• ka hōʻemi ʻana o ka hōʻino ʻana o ka CVD i nā mea maʻi me ka diabetes mellitus type 2 me ka hoʻopōʻino i nā mea pili,
• atherosclerosis ʻōpala koʻikoʻi.

• maʻi kūʻai i nā mea o ka lāʻau,
• ʻOi aku ka 2 a me 3 i mau mānoanoa o ka wā hāpai, ʻōpiopio.
• makahiki ʻokoʻa
• hapai ana i ke alahana,
• hoopoino loa ia i ka pepi,
• hipokalemia Refractory a me ka hypercalcemia,
• kohola
• hana like me Aliskiren i ka maʻi diabetes.

Ma muli o ka lawa ʻole o ka noiʻi, ʻaʻole pono e hāʻawi i ka lāʻau lapaʻau i nā keiki ma lalo o 18 makahiki o ka makahiki. Ke papa ʻole ʻia ka lawe ʻana i ka lāʻau lapaʻau i ka wā hapai, ka mea nui i ka trimester 2 a me 3, ʻo ka mea ola ka hopena fetotoxic kiʻekiʻe: kahi hoʻohaʻahaʻa i ka hana o ka ʻōnaehana excretory, kahi lohi i ka ossification, a me oligohydramnios.

I nā pēpē hou, aia: ke hoʻonui ʻia o ka manaʻo o ka pāhana, hoʻemi i ke kaomi, paʻa ʻole o ka ʻōnaehana excretory. Pono e hoʻokaʻawale ʻia nā Sartans a ua hoʻololi pū ʻia me kekahi pūʻulu o nā lāʻau lapaʻau. E nānā pono e kiaʻi pono i ka kuʻi a me ka makuahine.

Nā ʻōkuhi no ka hoʻohana

Lawe ʻia ka lāʻau i hoʻokahi manawa i kēlā me kēia 24 mau manawa i ka manawa like, me ka ʻole o ka ʻaina. Inu i nā ano he nui. E like me nā kuhikuhi no ka hoʻohana ʻana o Telsartan, ʻo 20 mg ka hoʻomaka mua, a laila hiki ke hoʻonui mālie ʻia. ʻO kahi maʻa o 40 mg o ka maʻamau he therapeutically maikaʻi. I nā poʻe maʻi "hoʻomau" hiki iā ʻoe ke hoʻonui i ka nui ma 80 mg i kēlā me kēia lā, akā ʻaʻole keu. ʻO ka palena nui loa kēia.

Ma ke ʻano hou o ka hiki ʻole o ka monotherapy, ka hui pū ʻana o ka blocker receptor na kaiotensin a me kahi diuretic, hoʻohana ʻia ka lāʻau lapaʻau Telsartan N.

ʻAʻole ia e hui pū i ka lawe ʻana i ka Telsartan me ka hoʻomākaukau ʻana i ka paʻakai, nā mea paʻa o ka ACE, saluretics potassium-sparing, NSAIDs, Heparin, immunosuppressants - nā mea hiki ke hoʻonāukiuki i ka nui o nā paʻakai pālolo ma ke kino. ʻAʻole pono ke hoʻohana pono ʻana me ka hoʻomākaukau ʻana me ka lithium, no ka mea, hiki i kēia ke alakaʻi i ka nui o nā mea.

Hōʻike pinepine nā maʻi maʻi hypertensive inā hiki ke lawe ʻia ʻo Telsartan a me Diuver i ka manawa like. Ua hōʻike ʻia nā haʻawina ʻo ka hoʻohana pū ʻana o ka telmisartan a me ka torasemide, ʻo ia nā mea kōkua koʻikoʻi o kēia mau lāʻau, ke alakaʻi nei i ka kahe nui o ke koko.

E hoʻohana i kēia hui me ka akahele, no ka mea, ʻo ka nui o ka hoʻopā nui ʻana e hiki ke alakaʻi i ka hypotension. Ma mua o ka hoʻohana ʻana i kekahi lāʻau lapaʻau, a ʻoi aku hoʻi no kā lākou hui pū ʻana, pono ʻoe e nīnau me kāu kauka.

Hiki paha nā hopena ʻaoʻao a overdose

Hiki i ka overdose ke hoʻoweliweli i kēia mau hopena:

• hypotension
• tachycardia
• nā hōʻailona dyspeptic
• nā mālamalama maikaʻi ʻole.

He papa inoa ʻole nā ​​lāʻau lapaʻau e pili ana i nā hopena o ka hopena, he luhi naʻe kekahi:

• ʻono,
• arrhythmia, tachycardia,
• āhāhuʻe
• vertigo
• palapalai
• hōʻike kūmole.

ʻO nā mea hana nui no ka lāʻau Telsartan:

• Mikardis.
• Telzap
• Telmista.
• Telpres.
• Koiā ʻia.
• Tanidol.
• Kauhi.
• Hipotel.

ʻO ka ʻokoʻa nui ma waena o kēia mau lāʻau, ke kumukūʻai, ke ʻano like kekahi ʻāina ʻāina, kahi e pili ana i ka maikaʻi o ka hoʻomaʻemaʻe ʻana o nā ʻāpana o ka lāʻau. I ka waiwai, ua like nā lāʻau lapaʻau. Akā ʻo nā meaʻala maikaʻi loa ʻo Mikardis, Praitor a me Telpres.

Hōʻikeʻike i nā kauka a me nā maʻi

Ma ka laulā, ua hāʻawi nā loea a me nā mea maʻi i nā loiloi maikaʻi o ka lāʻau lapaʻau, eia kekahi o lākou:

ʻO Alexander Dmitrievich, cardiologist: "ʻO ka lāʻau lapaʻau ke haʻi a me ka hoʻopiʻi maikaʻi ʻana i ka pume. ʻO kona hopena e lōʻihi i ka wā lōʻihi.

ʻO kahi hiʻohiʻona a me ka hoʻomaʻamaʻa maikaʻi loa kona nūhou mau i nā hopena ʻino o ka angiotensin aʻo ka mālama ʻana i ka maikaʻi. I lawa e lawe i hoʻokahi papa o ka lā. He mea kūpono loa ia e koho a hoʻoponopono i ke kūpaʻa. ʻO ka lāʻau o ka hanauna hou me ka liʻiliʻi o ka hopena o nā hopena lāʻau. "

Ma muli o ka ʻike i ʻike ʻia i ka lāʻau lapaʻau, hiki iā mākou keʻike wiwi aku i kēia lā ʻo ia kekahi o nā mea e hoʻohana ai i ka lāʻau antihypertensive. Hoʻopili wale aku ana i ka maikaʻi a mālama i ka hopena maikaʻi ma ka pūnaehana cardiovascular a me ke kino holoʻokoʻa.

Inoa Kūʻai ʻole honua

INN lapaʻau - Telmisartan.

I ka papa hoʻonohonoho o ATX, ua loaʻa ka lāʻau lapaʻau i ka code C09CA07.

Hoʻomaopopo ʻia ka hoʻohana ʻana o Telsartan no kahi mau kūlana o ka pathological, i hui pū ʻia me ka hoʻonui o ke kahe koko.

Lapaʻau lāʻau

Ke lawe nei i ka lāʻau lapaʻau, ʻike koke ʻia kāna mea ikaika. Loaʻa ka bioavailability 50%. ʻO ka lōʻihi o ke kau ʻana o ka lāʻau i loko o ke koko i nā kāne a me nā wahine i loaʻa 3 mau hola ma hope o ka hoʻokele ʻana. Hoʻopaʻa ka lāʻau i nā protein plasma. Hoʻomau ka lāʻau metabolism me ka komoʻana o nā waikawa glucuronic. Hoʻopau nā Metabolites i nā feces i loko o 20 mau hola.

Me ka mālama pono

ʻO ka maʻi me ka telsartan e mālama nui loa i ka renal aren stenosis. Eia kekahi, ʻo nā mea maʻi me ka stenosis valve mitral a aicic i ka wā o ka hoʻouka ʻana me Telsartan e koi pono i ka mālama kūikawā mai nā limahana olakino. Pono ka mālama kūikawā e mālama ʻia me ka hypokalemia a me hyponatremia. Hiki ke hoʻohana i ka huahana wale nō ma lalo o ka mākaʻina kokoke o nā kauka a inā he mea maʻi me ka mōʻaukala o kahi hoʻololi o ke keiki.

Me ka maʻi diabetes

No ka poʻe maʻi e loaʻa ana i ka maʻi diabetes type 2, ua kuhikuhi ʻia nā lāʻau lapaʻau ma kahi hoʻomaka ʻana o 20 mg. I ka wā e hiki mai ana, hiki ke hoʻonui ʻia i ka nui o ka lā i ka 40 mg.

ʻAʻole ʻai ka ʻai i ka hoʻopili ʻana o ka mea ikaika o ka lāʻau.

Mai ka pūnaehana genitourinary

Hoʻokumu kekahi mau maʻi i ka cystitis. I nā hanana pinepine, e kūʻē i ka maʻi ʻana o ka maʻi nui o ka ʻōnaehana genitourinary, hiki mai paha ka sepsis.

Hoʻokumu kekahi mau maʻi i ka cystitis.

Ma ka ʻāpana o ka ate a me ka pāpaʻi biliary

He mea kupaianaha loa ia ma ka mālama ʻia ʻana o Telsartan aia kahi kūʻole i ka hana o nā ate a me nā pāpaʻi biliary.

He mea kupaianaha loa kēia ma ka mālama ʻia ʻana o Telsartan aia kahi kāpae hana i nā hana ate.

Inā hele ka hypersensitivity i ka mea maʻi, hiki i nā hopena kūlohelohe, hōʻike ʻia e like me ke ʻano a hōʻopala i ka ʻeha a me ka ʻeha, me ka edema o Quincke.

Hoʻohana i ka wā hāpai a me ka lactation

ʻO ka ʻoi aku ka lāʻau me Telsartan no nā wahine i nā mea āpau a pau o ka hāpai ʻana, ʻaʻole i ʻike ʻia. ʻAʻole hōʻike ʻia e hoʻohana i nā lāʻau lapaʻau no ka umauma.

ʻO ka ʻoi aku ka lāʻau me Telsartan no nā wahine i nā mea āpau a pau o ka hāpai ʻana, ʻaʻole i ʻike ʻia.

Ke noi no ka hana lawelawe lēʻaleʻa

ʻAʻole pono e hoʻohana ʻia ka lāʻau lapaʻau i ka mālama ʻana i ka poʻe me ka maʻi o ka puʻu, i hele pū ʻia me ka hāpau o ka maʻa biliary a me cholestasis.

ʻAʻole pono e hoʻohana ʻia ka lāʻau lapaʻau i ka mālama ʻana i ka poʻe me ka maʻi o ka puʻu, i hele pū ʻia me ka hāpau o ka maʻa biliary a me cholestasis.

Hoʻolaha ka waipuna

E hōʻole ʻoe e inu i ka waiʻona i ka wā o ka mālama ʻana me Telsartan.

E hōʻole ʻoe e inu i ka waiʻona i ka wā o ka mālama ʻana me Telsartan.

Nā huaʻōlelo Telsartan e loaʻa ana i ka hopena therapeutic like: