Lorista - nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana, nā loiloi, nā analogues a me nā puka i hoʻokuʻu ʻia (nā papa 12, 5 mg, 25 mg, 50 mg a me 100 mg, N a me ND - e hui pū me nā diuretic hydrochlorothiazide) nā lāʻau lapaʻau no ka mālama ʻana i ke koko kiʻekiʻe ma nā pākeke, nā keiki a me ka wā hāpai

I kēiaʻatikala, hiki iā ʻoe ke heluhelu i nā ʻōkuhi no ka hoʻohana ʻana i ka lāʻau lapaʻau Lorista. ^ E Ha yM. Hāʻawi i ka hoihoi mai ka poʻe kipa i ka pūnaewele - nā mea kūʻai o kēia lāʻau lapaʻau, me nā manaʻo o nā loea lapaʻau e pili ana i ka hoʻohana ʻana o Lorista i kā lākou hana. ʻO kahi noi nui, ʻo ia ke hoʻoikaika ikaika i kāu mau loiloi e pili ana i ka lāʻau lapaʻau: kōkua ka lāʻau lapaʻau a ʻaʻole hoʻi i kōkua i ka hoʻopiʻi ʻana i ka maʻi, nā mea hoʻopiʻi a me nā hopena ʻaoʻao, ua ʻike ʻia, ʻaʻole i hoʻolaha ʻia e ka mea hana ma ka annotation. Kau mau ʻistalelo Lorista ma ke alo o nā mea hoʻopili alolako. Hoʻohana no ka mālama ʻana i ke koko koko kiʻekiʻe i nā pākeke, nā keiki, me ka wā hāpai a me ka lactation.

Lorista - Angiotensin selectile 2 mau receptor antagonist ʻano AT1 i ʻole nā kaine-protina.

ʻO Losartan (ka hana ikaika o ka lāʻau Lorista) a me kāna metabolito carboxy hoʻoikaika (EXP-3174) i kāohi i ka hopena o ka physiologically nui o ka angiotensin 2 ma nā mea hoʻokipa AT1, me ka mea o ke ala o kāna synthesis: alakaʻi ia i ka hoʻonui ʻana i ka hana renin plasma a me kahi laʻa i ka hoʻoliʻi ʻana o ka ald testosterone i loko o ke kaila koko.

Ma kahi kūwaho kūwaho ʻo Losartan i ka hoʻāla ʻana o ka ʻĀpana AT2 ma o ka hoʻonui ʻana i ka pae o ka angiotensin 2. ʻAʻole i ʻoka ʻo Losartan i ka hana o ka kininase 2, kahi kinehu i hoʻopili ʻia i ka hana o ka bradykinin.

He hōʻemi ia i OPSS, kaomi i ke kaomi pulmonary, e hōʻemi ana ma hope o ke kaumaha, he hopena diuretic.

Kūleʻa ʻia me ka hoʻomohala ʻana o ka hypertrophy myocardial, hoʻonui i ka hoʻolahalaha ʻana i nā maʻi me nā maʻi ʻoi ʻole ka maʻi.

Loaʻa ia ʻo Lorista hoʻokahi manawa i ka lā e alakaʻi i kahi emi nui o ka systolic a me ka diastolic blood pressure. I loko o ka lā, ke kaohi nei ka losartan i ke kahe o ke koko, aʻo ka hopena antihypertensive e pili i ka ʻenikani circadian kūlohelohe. ʻO ka emi o ke kahe o ke koko i ka hopena o ka hopena o ka lāʻau lapaʻau ma kahi o 70-80% o ka hopena i ka hopena o ka lāʻau, 5-6 mau hola ma hope o ke lawelawe ʻana. ʻAʻole mālama ʻia ka maʻi kahalike, a ʻaʻohe o ka losartan i ka hopena koʻikoʻi ma o ka puʻuwai puʻuwai.

Maikaʻi ʻo Losartan i nā kāne a me nā wahine, ʻoiai ʻo ia i nā ʻelemakule (≥ 65 mau makahiki) a me nā mea maʻi ʻōpio (≤ 65 mau makahiki).

ʻO ka Hydrochlorothiazide kahi diuretic thiazide ka mea i ka hopena diuretic me ka hoʻopiʻi ʻana i ka reabsorption o ka sodium, chlorine, potassium, magnesium, nā wai wai i ka nealron neʻalone, e hoʻolei i ka hoʻopuka ʻana o nā meons calcium, uric acid. Loaʻa ia ia nā waiwai antihypertensive, ulu ka hopena hypotensive ma muli o ka hoʻonuiʻana o ka arterioles. ʻAʻohe hopena i kahi kahe koko maʻamau. Hoʻopilikia ka hopena diuretic ma hope o nā hola 1-2, hiki i kahi lōʻihi ma hope o 4 mau hola a lōʻihi i ke hola 6-12.

Ke hopena nei ka hopena antihypertensive ma hope o nā lā 3-4, akā hiki paha i nā wiki 3-4 e hoʻokō ai i ka hopena therapeutic maikaʻi loa.

Hōʻike

ʻO nā makana heva ma + Chartart.

ʻOsi ka ʻaiā losartan + hydrochlorothiazide + nā mea hanohano (Lorista N a me ND).

Lapaʻau lāʻau

ʻO nā pharmacokinetics o losartan a me hydrochlorothiazide me ka hoʻohana like ʻole i ʻokoʻa ʻole i ko lākou hoʻohana ʻokoʻa.

Ua hoʻonoono maikaʻi ʻia mai ka papa hana ʻole. ʻO ka lawe ʻana i ka lāʻau me ka meaʻai, ʻaʻohe hopena koʻikoʻi ʻoi loa e pili ana i ka serum. ʻAʻole aneane e komo i ke koko-lolo (BBB). Ma kahi o 58% o ka lāʻau ua hoʻopau i ka bile, 35% - i loko o ka pāʻai.

Ma hope o ka lawelawe waha, ʻo ka hoʻokomo ʻana o ka hydrochlorothiazide, ʻo 60-80%. ʻAʻole i hoʻohālikelike ʻia ka Hydrochlorothiazide a ua lawe wikiwiki ʻia e nā keiki.

Nā Hōʻike

haehae maʻi
hōʻemi iki i ka hopena o ka maʻi ma nā maʻi me ka hypertension arterial a waiho aku i ka hypertrophy ventricular,
ka huhū o ka puʻuwai kūpilikiʻi (ma ke ʻano he hui hoʻohui, me ka intolerance a i ʻole ka launa ʻana o ka maʻi me ka ACE inhibitors),
ka pale ʻana i ka hana kidney ma nā mea maʻi me ka diabetes mellitus type 2 me ka proteinuria e hōʻemi i ka proteinuria, e hōʻemi i ka holomua o ka hōʻeha o ka pūpū, e hōʻemi ana i ka hoʻoulu ʻana i ka ʻōpū (pale i ka pono o ka dialysis, ʻānō e hoʻonui ka serum creatinine) a i ka make.

E hoʻokuʻu i nā palapala

Nā Papa 12,5 mg, 25 mg, 50 mg a me 100 mg.

Lorista N (hoʻohui pū ʻia ka 12.5 mg o hydrochlorothiazide).

Lorista ND (hoʻohui ʻia he 25 mg o ka hydrochlorothiazide).

Nā ʻōkuhi no ka hoʻohana a me ka helu ʻana

Lawe ʻia ka lāʻau lapaʻau ma ke ʻano, me ka mea ʻole i ka ʻai, ʻo ke alapine ʻana o ka hoʻokele - 1 manawa i kēlā me kēia lā.

Me ka hypertension arterial, ʻo ka awelika o ka awelika o kēlā me kēia lā he 50 mg. Loaʻa ka hopena kiʻekiʻe antihypertensive i loko o 3-6 mau pule o ka maʻi. Hiki ke hoʻokō i kahi hopena hou aʻe ma o ka hoʻonui ʻana o ka make o ka lāʻau i ka 100 mg i kēlā me kēia lā i ʻelua mau hopena a i ʻole hoʻokahi pae.

ʻOiai e lawe ana i ka diuretics i nā inikini kiʻekiʻe, ke koho ʻia e hoʻomaka i ka therapy ʻo Lorista me 25 mg i kēlā me kēia lā i kahi hoʻokahi.

ʻO nā maʻi ʻōpiopio, nā mea maʻi me ka hana renal impaired (me nā mea maʻi i ka hemodialysis) pono pono e hoʻoponopono hou i ka hopena mua o ka lāʻau.

I nā maʻi me ka pīhoihoi hana ʻōmaʻomaʻo, e pono ke kuhikuhi i ka lāʻau ma kahi haʻahaʻa.

Ma ka hana hema ʻana o ka puʻuwai, ʻo ka hoʻomaka mua ʻana o ka lāʻau lapaʻau he 12.5 mg i kēlā me kēia lā i kahi pākahi. I mea e hoʻokō ai i ka nui o ka mālama mālama ʻia o 50 mg i kēlā me kēia lā, pono ke hoʻonui ʻia ka nui o ka make, ma waena o 1 hebedoma (no ka laʻana, ʻo 12.5 mg, 25 mg, 50 mg no ka lā). Kūkā ʻia ʻo Lorista i ka hui pū me ka diuretics a me nā glycosides cardiac.

No ka hōʻemi i ka hopena o ka hōʻeha ma nā maʻi me ka hypertension arterial a waiho aku i ka hypertrophy ventricular, ʻo ka paila palena mua o 50 mg i kēlā me kēia lā. I ka wā e hiki mai ana, hiki ke hoʻohui ʻia ka hydrochlorothiazide i nā haʻahaʻa haʻahaʻa a / a i ʻole ke momona a Lorista e hoʻonui ʻia i 100 mg i kēlā me kēia lā.

No ka pale aku i nā kauā i nā maʻi me ka diabetes type type 2 me ka proteinuria, ʻo ke ʻano kaulike mua mua o Lorista he 50 mg i kēlā me kēia lā. Hiki ke hoʻonui ʻia ka hopena o ka lāʻau i ka 100 mg i kēlā me kēia lā, e noʻonoʻo ai i ka emi ʻana o ke koko.

Kolepa

āhāhuʻe
ʻaiaiaia
lie kanikela
mea momona
ʻōpala
hopohopo
hiamoe a hiamoe ʻole
hiamoe
nā hoʻomanaʻo hoʻomanaʻo
peripheral neuropathy,
aloha
hale hoʻokaumaha
migraine
hāpau
manaʻo ʻino
orthostatic hypotension (dosis-hilinaʻi),
puʻuwai puʻuwai
tachycardia
brieociaia
nā arrhythmias
ʻinalelo angina pectoris
ihu ʻōpala
huhū
ʻOluomini
ka ʻōpū ʻana o ka muha,
paila, mamaila,
nā ninia
ʻeha ka ʻōpū
anorexia
ka malo maloʻo
nūloʻā
he ʻano hūnā
constipation
koi aku i ka urinate
huakaʻi renal function,
hoʻemi i ka libido
huakai
nahoa
ʻeha ma hope, ʻāʻī, nā wāwae,
kani ana i na pepeiao
nā kuhi hewa
ʻike maka
konohiki
anemia
ʻO ka poni Shenlein-Genoch
maloʻo maloʻo
hoʻonui hoʻonui ʻia
alopecia
kohola
urticaria
ʻili ka ʻili
huu
angioedema (me ka komo ʻana o ka larynx a me ka alelo, e hoʻopiʻi ai i nā ʻōhua o ke ala a me / a me ka haki ʻana o ka maka, nā lehelehe, pharynx).

Nā Hoʻohui

haehae
hyperkalemia
huehue
lactose intolerance,
galactosemia aiʻole glucose / galactose malabsorption syndrome,
hapai
lactation
a hiki i nā makahiki 18 a (ʻaʻole i hoʻokumu ʻia ka pono a me ka palekana i nā keiki),
hypersensitivity a losartan a me / a me nā mea ʻē aʻe o ka lāʻau lapaʻau.

ʻŌpū a me ka lactation

ʻAʻohe ʻikepili i ka hoʻohana ʻana iā Lorista i ka wā hāpai. Hoʻololi i ka pūnao Renal o ka pūpū, ka mea e hilinaʻi ana i ka hoʻokumu ʻana o ka ʻōnaehana renin-angiotensin, e hoʻomaka i ka hana ma ka lāʻomaʻo 3 a ʻoi ka hapai. Hoʻonui ka hakakā o ka pūpiki i ka wā e lawe ai i ka losartan i ka mea hana 2 a me 3. Ke hāpai ʻia ka hapai, hiki ke hoʻokuʻu koke i ka lāʻau losartan.

ʻAʻohe ʻikepili i ka hāʻawi ʻana i ka losartan me ka waiū umauma. No laila, ʻo ka pilikia o ka ho'ōki i ka pale umauma a hoʻopau paha i kahi maʻi me losartan e pono e hoʻoholo i ka noʻonoʻo ʻana i kona mea nui i ka makuahine.

Nā ʻōlelo kikoʻī

ʻO ka poʻe maʻi me ka hoʻemi haʻahaʻa o ka nehe koko (no ka laʻana, i ka wā o ka mālama ʻana me nā dosis nui o ka diuretics) e ulu i ka hypotension hypertension arterial. Ma mua o ka lawe ʻana i ka losartan, pono ia e hoʻopau i nā hōʻino i kēia manawa, a hoʻomaka e hoʻomaka i ka lāʻau me nā dosis liʻiliʻi.

I nā mea maʻi me ka cirrhosis māmā a me ka maʻalahi o ka pepeke, ka ʻike o ka losartan a me kāna metabolite hoʻoikaika i ka plasma koko ma hope o ka lawelawe ʻana i ka waha i ʻoi aku ka kiʻekiʻe ma mua o nā mea olakino. No laila, e hāʻawi ʻia nā mea maʻi me ka mōʻaukala o ka maʻi maʻa i kahi haʻahaʻa o ka maʻi.

I ka poʻe maʻi me ka hana renal impaired, me ka ʻole ʻole o ka maʻi diabetes, ulu pinepine ka hyperkalemia, pono e noʻonoʻo ʻia, akā aia wale nō i nā hihia hanana nā hopena o kēia hopena, ua pau ka mālama ʻana. I ka wā o ka mālama ʻana, mālama pono ʻia ka paʻū o ka pāhana i loko o ke koko, ʻoi aku ka nui o nā poʻe maʻi maʻi, me ka hana ʻole o ka renal.

Hiki i nā lāʻau lapaʻau e hana ana i ka ʻōnaehana renin-angiotensin hiki i ka serum urea a me ka mea hana i loko o nā mea maʻi me ka bilateral renal artery stenosis a i ʻole ka ʻaoʻao hoʻokahi i ka stenosis hoʻokahi o ke akeʻa. Hiki ke hoʻololi hou ʻia nā loli ʻana ma hope o ka hoʻokuʻu ʻana i ka maʻi. I ka wā mālama, pono e nānā pinepine i ka ʻike ʻana o ka creatinine i loko o kahi serum koko i nā manawa maʻamau.

Hoʻokomo i ka hiki ke lawe i nā kaʻa a kāohi i nā mīkini

ʻAʻohe ʻikepili e pili ana i ka hopena o Lorista i ka hiki ke hoʻokau i nā kaʻa a i ʻole nā ʻano ʻenehana ʻē aʻe.

Hoʻohui nūhou

ʻAʻole ke ʻano o nā hōʻuluʻulu maʻi o ka maʻi me ka hydrochlorothiazide, digoxin, kūlohelohe anticoagulants, cimetidine, phenobarbital, ketoconazole a me ka erythromycin i nānā ʻia.

I ka wā o ka hoʻohana mua ʻana me ka rifampicin a me fluconazole, ua ʻike ʻia kahi emi o ke kaohi o ka metabolite ikaika o ka potassium losartan. ʻAʻole maopopo ka hopena o nā maʻi maʻi o kēia hanana.

Hoʻohana i ka manawa like me ka potassium-sparing diuretics (no ka laʻana, spironolactone, triamteren, amiloride) a me ka hoʻomākaukau ʻana i ka paʻakai ka hoʻonui ʻia ʻana o ka hopena o ka hyperkalemia.

ʻO ka hoʻohana like ʻana o nā lāʻau anti-inflammatory non-steroidal, me nā mea koho selective COX-2, hiki ke hōʻemi i ka hopena o nā diuretics a me nā lāʻau antihypertensive.

Inā ʻōlelo ʻia ʻo Lorista i ka manawa like me ka thiazide diuretics, ʻo ka emi ʻana o ke koko, ʻoi aku ka pili o ke ʻano ma ke ʻano. Hoʻonui (kūleʻa) i ka hopena o nā lāʻau antihypertensive a pau (diuretics, beta-blockers, sympatholytics).

Nā hōʻike o ka lāʻau Lorista

Hoʻololi nā kumu hoʻohālike o ka waiwai ikaika:

Blocktran
Brozaar
Vasotens,
Vero Losartan
Zisakar
Hanohano Sanovel,
Karzartan
Keola
Lakea
Lozap,
Lozarel
Losartan
Pākana kala,
Kālehu
Lotor
Presartan,
Renicard.

Nā ʻōmike Lorista

He aha nā mea e kōkua ai iā Lorista papa? Hōʻike ʻia ka lāʻau lapaʻau no nā maʻi a me nā kūlana:

Hypertension arterial (inā hōʻike ʻia ke ʻano hui like)
ʻO ka haole hypertrophy a me ka hypertension e hoʻemi i ka hopena o ka ʻeha,
ʻO CHF ma kahi o ka hui hoʻohui ʻana,
ʻO Neprology (pale aku i ka lolo) i nā mea maʻi me ka diabetes mellitus type 2 i mea e hōʻemi ai i ka protenuria,
ʻO ka paleʻana i nā ulia o ka maʻi cardiovascular, ʻo ka mea hoʻi i hōʻeha ʻia, i nā mea maʻi me ka kiʻekiʻe o ka maʻi.

Wahi a nā ʻōlelo kuhikuhi, kōkua ʻo Lorista N me ka pono o ka hoʻomaʻamaʻa hui ʻia me nā lāʻau antihypertensive a me ka diuretics.

Nā papa pōkao Lorista 50 100 mg - nā ʻōlelo aʻoaʻo no ka hoʻohana

Lawe au ma ke ʻano maʻamau, me ko ka ʻaina, inu i ka wai maʻemaʻe. Ke kono ʻia nei e lawe i Lorista i ke kakahiaka.
Me ka hypertension arterial, ʻo ka awelika o ka awelika o kēlā me kēia lā he 50 mg. Loaʻa ka hopena kiʻekiʻe antihypertensive i loko o 3-6 mau pule o ka maʻi.

Hiki ke hoʻokō i kahi hopena ʻoi loa e ka hoʻonui ʻana i ka lāʻau o ka lāʻau i ka 100 mg / lā.

Pono e hoʻonui ʻia ka nui o ka lāʻau e like me ke ʻano i kēia hana.

Lapa 1 mau (1st - lā 7) - 1 mau papa. Lorista 12.5 mg / lā.
Hōʻike 2 wiki (lā 8-14) - 1 papa. Lorista 25 mg / lā.
Helu 3 (15-21st lā) - 1 mau pā. Lorista 50 mg / lā.
Ke 4 wiki (22-28 lā) - 1 kīpē. Lorista 50 mg / lā.

E kū'ē i ke kua o ka lawe ʻana i ka diuretics i nā inikini kiʻekiʻe, ke manaʻo ʻia e hoʻomaka i ka hopena Lorista me 25 mg / lā. Loaʻa ka hopena antihypertensive kiʻekiʻe i loko o 3 mau pule o ka maʻi.

I nā mea maʻi me ka hana renal impaired (CC 30-50 ml / min), ʻaʻole koi ʻia ka hoʻoponopono ʻana o ka inea mua o Lorista.

No ka hoʻēmiʻana i ka hōʻeha o nā pathologies cardiovascular a me ka make ma nā poʻe maʻi me ka hypertension arterial a waiho aku i ka hypertrophy ventricular, hoʻohana ʻia ka mua a me ka mālama mālama ʻana i ka losartan - 50 mg 1 manawa / lā (1 papa o Lorista 50).

Inā ma ke ʻano o ka mālama ʻana ʻaʻole hiki ke hoʻokō i ke pae o ke kaila o ke koko i ka wā e noi ana iā Lorista N 50, e pono ke hoʻoponopono. Inā pono, hiki ke hoʻonui ʻia ma ke ʻano (Lorista 100) me ka hydrochlorothiazide ma ke ʻano o 12,5 mg / lā hiki.

ʻO ka papa ʻōlelo i hōʻike ʻia i ka lāʻau Lorista® N 100 -1 tab. (100 mg / 12.5 mg) 1 manawa / lā.

ʻO ka lālau nui no kēlā me kēia lā he 1 tab. lālani Lorista N 100.

Mālamua:

I nā maʻi me ka hana renal impaired, ʻaʻole pono ka hoʻoponopono ʻana.

I nā poʻe maʻi maʻi, ʻaʻole pono ka hoʻoponopono ʻana o ka inika.

I nā poʻe maʻi me ka hana lūlū hemahema, pono e hōʻemi ʻia kahi nui o Lorista. I CHF, ʻo ka papa helu mua he 12.5 mg / lā. A laila e hoʻonui mālie ʻia ka nui a hiki i ka hōʻea ʻana i kahi maʻa therapeutic maʻamau. Hōʻike ka hoʻonui i hoʻokahi manawa i ka hebedoma (no ka laʻana, 12.5 mg, 25 mg, 50 mg / lā). Kēia mau mea maʻi, nā ʻōlelo no nā papa āpau o Lorista e hoʻonohonoho pū me ka diuretics a me nā glycosides cardiac.

I mea e pale ai i nā kidney i nā maʻi me ka diabetes type type 2 me ka proteinuria, ke ʻano kumu mua mua o Lorista ʻo 50 mg / lā. Hiki ke hoʻonui ʻia ka nui o ka lāʻau i ka 100 mg / lā, e noʻonoʻo ana i ka emi ʻana o ke koko. ʻO ka hoʻonui aʻe aʻe ma mua o 1 papa papaʻa o Lorista® N 100 i kēlā me kēia lā ʻaʻole i aʻo ʻia a alakaʻi i nā hopena ʻaoʻao.

ʻO ka hoʻohana pinepine ʻana o losartan a me ACE inhibitors ke hoʻopulapula i ka hana a ka lua, no laila, ʻaʻole i kuhikuhi ʻia kēia hui.

Hoʻohana i ka mea maʻi me ka hoʻohaʻahaʻa ʻana i ka nui o ka wai o intravascular - hoʻoponopono ʻia i ka nui o ka wai o ka wai o ka wai ma mua o ka hoʻomaka ʻana o losartan.

Nā Manaʻohui Lorista

hypersensitivity a losartan and sulfonamide derivatives (hydrochlorothiazide), a i ʻole nā mea e kuʻi,
pilikia hōʻeha loa (hana hoʻopihapiha hana ʻana
2 makahiki

Nā kūlana mālama
I kahi wahi maloʻo, ma kahi mahana ʻaʻole iʻoi aku ma mua o 30 ° C.

E hoʻokuʻu i nā palapala

10 - blisters (3) - nā ʻeke pepa. 30 tab i i hui kūhelu 7 - blisters (14) - nā pā o ka pahu. 7 - blisters (14) - nā ʻeke pepa. 7 - blisters (2) - nā pākeke o ke kāleka. 7 - blisters (4) - nā ʻeke pepa. 7 - blisters (8) - nā ʻeke pepa. 7 - blisters (12) - nā ʻeke pepa. 7 - blisters (14) - nā ʻeke pepa. 100 mg + 25 mg mau papa kiʻi ʻoniʻoni - 30 tab. 100 mg + 25 mg mau papaʻa ʻoniʻoni - 60 papa pack e 30 mau papa pakana 60 papa papa e 90 nā papa

ʻO ka wehewehe ʻana i ke ʻano dosis

Nā papa hana hoʻoili kiʻi ʻoniʻoni, ʻōwili uhi ʻia nā kiniponi i ka melemele me ke kahe ʻona, he oval, he biconvex, me ka loaʻa ʻana o ka ʻaoʻao ma kahi ʻē. ʻO nā papa, i ulana ʻia mai ka melemele a i ka melemele me ke kaʻe o ka pua ʻōmaʻomaʻo, he oval, he biconvex.

Nā kūlana kūikawā

1 kōpō pākōlio losartan 100 mg hydrochlorothiazide 25 mg Mīwīwī: nā kīpē pregelatinized - 69.84 mg, cellulose microcrystalline - 175.4 mg, mole lactose lōmole - 126.26 mg, magnesium stearate - 3,5 mg. ʻO ka mana o ka membrane film: hypromellose - 10 mg, macrogol 4000 - 1 mg, dye quinoline yellow (E104) - 0.11 mg, titanium dioxide (E171) - 2.89 mg, talc - 1 mg. pākōlio losartan 100 mg hydrochlorothiazide 12,5 mg ʻO nā kumuwaiwai: nā māka pregelatinized, cellulose microcrystalline, lōmole lactose, magnesium stearate. Hōʻuluʻulu Shell: hypromellose, macrogol 4000, quinoline kūmole melemele (E104), titanium dioxide (E171), talc. pākōlio losartan 100 mg hydrochlorothiazide 25 mg ʻO nā mea kuahiwi: nā māka pregelatinized, cellulose microcrystalline, lactose monohala, magnesium stearate. Hōʻuluʻulu Shell: hypromellose, macrogol 4000, quinoline kūmole melemele (E104), titanium dioxide (E171), talc. potassium losartan 50 mg hydrochlorothiazide 12,5 mg ʻO nā mea kuʻuna: kano pregelatinized, kaila selolosa microcrystalline, lactose monohidate, magnesium stearate Shell komposisyon: hypromellose, macrogol 4000, quinoline kaila melemele (E104), titanium dioxide (E171), tal. pākōlio losartan 50 mg hydrochlorothiazide 12,5 mg ʻO nā mea kuʻina: ka huakaʻi pregelatinized, cellulose microcrystalline, lactose monohala, magnesium stearate. Hōʻuluʻulu Shell: hypromellose, macrogol 4000, quinoline kūmole melemele (E104), titanium dioxide (E171), talc.

Nā Lorista N contraindications

ʻO ka hypersensitivity a losartan, i nā lāʻau lapaʻau i loaʻa mai nā sulfonamides a me nā mea like ʻole o ka lāʻau lapaʻau, anuria, pilikia nui ʻole o ka hana renaline (creinine clearance (CC) ma mua o 30 ml / min.), Hyperkalemia, dehydration (me ka wā ke lawe i nā nui o ka diuretics) lima momona hōʻeha, maʻi hipokalemia refractory, hapai, lactation, hypotension arterial, makahiki ma lalo o 18 makahiki (ʻaʻole i hoʻokō ʻia ka hopena a me ka palekana), hemahema lactase, galactosemia a glucose / gal malabsorption syndrome Nā loina. Me ka mālama akahele: nā hana hoʻoliʻiliʻi o ka wai-electrolyte (hyponatremia, hypochloremic alkalosis, hypomagnesemia, hypokalemia), bilateral renal aren stenosis a i ʻole ka stenosis o hoʻokahi artery kidney, diabetes mellitus, hypercalcemia, hyperuricemia a / a i ʻole gout, i hoʻopili ʻia me kekahi anemone neurologicalal. hoʻomohala ʻia ma mua me nā lāʻau ʻē aʻe, me nā papa pale AP

Nā hopena ʻaoʻao Lorista N

Ma ka ʻāpana o ke koko a me ka ʻōnaehana lymphatic: pinepine: anemia, Shenlane-Genokha purpura. Ma ka ʻāpana o ka ʻōnaehana pale: aniani: nā anaphylactic reaksi, angioedema (me ka uhi ʻana o ka larynx a me ka alelo, e hoʻolalelale ana i nā ala mokulele a me / a kaʻi ʻana o ka maka, nā lehelehe, pharynx). Mai ka ʻaoʻao o ka pūnaehana nīkini waena a me nā ʻōnaehana hoʻoneʻe peripheral: mau pinepine: ka ʻeha, ka ʻōhumu a me ka hina ʻole systemic, ʻūhā, nā luhi, ka manawa maʻamau: migraine. Mai ke ʻano o ka pūnaʻi cardiovascular: pinepine: hypotension orthostatic (hilinaʻi-dosis), palpitations, tachycardia, ʻaʻole anuʻu: vasculitis. Mai ka papa hana hanu: pinepine: mauʻu, ʻihi ʻana o nā ʻōpū hanu kiʻekiʻe, ʻo ka pharyngitis, ka huehue o ka mucosa nasal. Mai ka ʻeha gastrointestinal: pinepine: nā maʻi o ka maʻi, nā dyspepsia, nausea, ka luaʻi, ka ʻeha o ka ʻōpū. Mai ka ʻōnaehana hepatobiliary: loaʻa pinepine: hepatitis, hana hana kōpaʻa hemahema. Mai ka ʻili a me ka momona o ke kūpaʻa: pinepine: urticaria, ʻeha ka ʻili o ka ʻili. Mai ka ʻōnaehana musculoskeletal a me ka hoʻopili hoʻohui: pinepine: myalgia, ʻeha ʻeha, pinepine pinepine: arthralgia. Nā mea ʻē aʻe: ka pinepine: asthenia, nāwaliwali, edema peripheral, ʻeha ʻeha. Nā hōʻailona mākaʻina: pinepine: hyperkalemia, hoʻonui ʻia o ka hemoglobin a me ka hematocrit (ʻaʻole i koʻikoʻi i loko), pinepine: hoʻonui nui ʻana i ka serum urea a me nā mea hana, maʻa pinepine loa: hoʻonui i ka hana o ka ate a me nā enzyir bilirubin.

25 mg, 50 mg a me nā papa papa kiʻi 100% i hana ʻia

Aia ma ka papa papa

mea waiwai - losartan pā 25 mg, 50 mg a me 100 mg,

i lokokaʻilii lokohaua loa: ka selulose, ka pregelatinized starch, palaoa starch, microcrystalline cellulose, anhydrous colloidal silicon dioxide, magnesium stearate

ukana moku: hypromellose, talc, propylene glycol, titanium dioxide (E171) (no nā dosages o 25 mg, 50 mg, 100 mg), ka quinoline melemele (E104) (no ka laʻana o 25 mg)

ʻO nā ʻola nā papa oval, me ka pākuʻi biconvex iki, i uhi ʻia me ka uhi ʻana o ke kiʻi ʻoniʻoni, me ka pilikia o kekahi ʻaoʻao (no ke ʻano he 25 mg).

Hoʻokomo ʻia nā papa ʻula ma kahi ʻano, me kahi pā anuʻu biconvex, i kāʻei ʻia me ka uhi ʻana o ke kiʻi keʻokeʻo, me kahi kakalaka ma kekahi ʻaoʻao a me kahi chamfer (no kahi keneta o 50 mg).

ʻO nā papa o ka oval me ka pūhaka liʻiliʻi o ka biconvex, i kālai ʻia me ka pale kiʻi ʻulaʻula (no kahi laʻana o 100 mg)

ʻO nā waiwai Pharmacological

Lapaʻau lāʻau

Ma hope o ka nānā ʻana, ua hoʻopili maikaʻi ʻia ka losartan mai ka ʻeha o ka gastrointestinal, hoʻomaʻamaʻa i ka metabolism koʻikoʻi i ka wā o ka papa mua ma o ka ate, ka hana ʻana o ka metabolite ikaika - ka waikoki carboxylic a me nā metabolite hoʻoilo ʻole. ʻO ka bioavailability o ka ʻōnaehana o losartan e like me 33%. Loaʻa ka awelika kiʻekiʻe o losartan i loko o 1 hola, a me kāna metabolite hoʻomohala i loko o 3-4 mau hola.

ʻOi aku ma kahi o 99% o losartan a me kāna metabolite hoʻoikaika e hoʻopaʻa ai i nā protein plasma, ʻoi aku ka albumin. ʻO ka nui o ka hoʻonuiʻana i ka losartan he 34 pā.

Ma kahi o 14% o losartan, hoʻokele wahaheʻe, ua hoʻohuli ʻia i kāna metabolite ikaika.

ʻO ka wehe i ka plasma o ka losartan a me kāna metabolite hoʻoikaika e like me 600 ml / min a me 50 ml / min, ma kēlā. ʻO ka hoʻomaʻemaʻe ʻana i ka renal o ka losartan a me kāna metabolite hoʻoikaika e like me 74 ml / min a me 26 ml / min, kēlā. Me ka hoʻokolohua waha o losartan, ma kahi o 4% o ka nui o ka nui e hoʻololi ʻia i loko o ka mimi, a ma kahi 6% i loko o ka ʻano o ka metabolite hoʻoikaika. ʻO nā pharmacokinetics o losartan a me kāna metabolite hoʻoikaika e kūlike me ka hoʻokūkū waha o ka potassium losartan i nā dosis a hiki i 200 mg.

Ma hope o ka nānā ʻana, ua ʻike ʻia ka ʻike ʻana o ka losartan a me kāna hoʻoneʻe mau i ka kō koko plasma nui, me ka hapalua o ke ola ka lōʻihi ma kahi o 2 mau hola a me 6-9 mau hola, kēlā. A loaʻa ka nui o 100 mg i hoʻokahi lā i ka lā, ʻaʻole losartan a me kāna neʻe ʻana i ka metabolite nui e hōʻiliʻili i ka plasma i loko o ka nui.

Ua hoʻokaʻawale ʻia ʻo Losartan a me nā metabolites i loko o ka bile a me ka urine: e pili ana i ka 35% a me 43%, kēlā, ua hoʻonui ʻia i loko o ka urine, a ma kahi o 58% a 50%, kēlā me kēia, excreted i nā feces.

Lapaʻau lāʻaumanā hui maʻi maʻi kūloko

I ka poʻe maʻi nā maʻi me ka hypertension arterial, ʻo ka ʻike ʻana o ka losartan a me kāna metabolite hoʻoikaika i ka plasma koko, ʻaʻole i ʻokoʻa loa ka poʻe i loaʻa i nā poʻe ʻōpio me nā hypertension arterial.

I ka poʻe maʻi me ka wahine hypertension arterial, ʻo ka nui o ka losartan i loko o ke koko he ʻelua mau manawa iʻoi aku ma mua o nā mea maʻi me nā kāne arterial hypertension, aʻo nā pae o ka metabolite ikaika i ka plasma koko, ʻaʻole i ʻokoʻa i ke kāne a me nā wahine.

I nā maʻi me ka cirrhosis waikahe māmā a me ke kaulike, nā pae o losartan a me kāna metabolite hoʻoikaika i ka plasma koko ma hope o ka lawelawe ʻana i ka waha ma 5 a me 1,7 mau manawa, kēlā, e kiʻekiʻe aʻe i nā maʻi kāne ʻōpio.

I nā maʻi me ka cleinine clearance ma luna o 10 ml / min, ʻaʻohe loli o ka plasma o ka losartan. Hoʻohālikelike ʻia me nā mea maʻi me ka hana maʻamau maʻamau, i nā mea maʻi ma ka hemodialysis, kahi AUC (wahi ma lalo o ka kukuhi-manawa o ka manawa) no ka losartan e like me ka nui o 2 mau manawa.

I nā mea maʻi me ka maikaʻi ʻole a i ʻole nā mea maʻi e hele ana i ka hemodialysis, ʻaʻole i loli ka pilaki ʻana o ka metabolite ikaika.

ʻAʻole hiki ke hoʻopau ʻia ka losartan a me ke metabolite ikaika e nā hemodialysis.

Lorista® - ka lāʻau antihypertensive, he waha ʻoniʻoni o ka pehu ʻ angpopopoponi II o ka mea antagonist receptor (type AT1). ʻO Angiotensin II kahi ʻano ikaika o ka pūnaha renin-angiotensin a ʻo kekahi o nā mea nui nui i ka pathophysiology o ka hypertension arterial. Hoʻopili ʻo Angiotensin II i nā ʻĀpana AT1 i loaʻa i nā ʻano kikoʻī (e.g., muscle vascular smooth, adrenal glands, kidney, and heart) a kumu i kekahi mau hopena koʻikoʻi ololi, me ka vasoconstriction a me ka hoʻokuʻu ald testosterone. Hoʻoulu ʻia hoʻi ka Angiotensin II i ka hoʻomaikaʻi ʻana o nā pūpū māla maikaʻi.

ʻO Losartan a me kāna lāʻau lapaʻau hoʻonaninani ikaika o ka metabolite E3174 e kāohi i nā hopena kino a pau o ka angiotensin II, me ke kumu o kona kumu a me ke ala biosynthesis.

Hoʻopili paʻa ʻo Lorista® i nā mea hōʻiliʻili AT1 a ʻaʻole i kāohi i nā mea hoʻokipa o nā ʻoni a me nā ʻoni kūwaho. Nona ke kuleana no ka hoʻoponopono ʻana i ka ʻōnaehana cardiovascular. Eia kekahi, ʻaʻole e pale ka losartan i ka hana o ka angiotensin-hoʻohuli i ka enzyme (kinase II), he mea hoʻouka i ka ʻeha o ka bradykinin.

ʻO kahi helu hoʻokahi o losartan i nā mea maʻi me ka maʻi haʻahaʻa o ka hypertension arterial e hōʻike ana i kahi nui o ka statistically nui i loko o ke systolic a me ka diastolic blood pressure. Hoʻonohonoho ka hopena kiʻekiʻe loa i nā hola 6 ma hope o ka hoʻokele ʻana, hiki i ka hopena therapeutic 24 mau hola, no laila ua lawa ia e lawe i hoʻokahi lā i ka lā. Hoʻopilikia ka hopena antihypertensive i ka pule pule mua o ka maʻi, a laila piʻi mālie a hoʻonui hou ʻia ma hope o 3-6 mau pule

He kūpono like ʻo Lorista® i nā kāne a me nā wahine, ʻoiai ʻo ia i nā elemakule (≥ 65 mau makahiki) a me nā mea maʻi liʻiliʻi (≤ 65 mau makahiki).

ʻO ka wehe ʻana i ka losartan i nā maʻi me ka hypertension ʻaʻole alakaʻi i ka piʻi nui o ke kahe koko. ʻOiai ke emi ʻana o ke kahe o ke koko, ʻaʻole i loaʻa i nā hopena koʻikoʻi nā losartan ma ka hopena o ka puʻuwai.

Nā hōʻailona no ka hoʻohana ʻana

- ka mālama ʻana i ka maʻi hypertension pono i loko o nā pākeke

- ka mālamaʻana i ka maʻi kauka i nā maʻi pākeke me ka hypertension

a ʻano type 2 diabetes mellitus me ka proteinuria ≥ 0,5 g / lā, ma kahi ʻāpana

- ka hoʻomaʻamaʻa ʻana o ka puʻuwai paʻakikī i nā maʻi pākeke

(ka hapa hema o ka echection ventricular ≤40%, paʻa paʻa paʻa

ke kūlana) i ka wā e hoʻohana ai nā angiotensin-conve inhibitors

ua manaʻo ʻia ka ʻaʻole hiki i ka enzyme ma muli o ka intolerance, keu

me ka hoʻomohala ʻana o ka ʻā, a i ʻole hoʻi i hoʻohālikelike ʻia ko lākou kumu

- hōʻemiemi hōʻemi o ka hōʻeha ʻana i nā maʻi pākeke me ka arterial

E-paʻa hypertrophy ECT a waiho i ka hypertrophy ventricular

ʻLoe a me ke kākele

I loko, e pili ʻole ana i ka ʻahaʻaina. Pauna ʻia ke papa me ka ʻaʻa ʻole ʻia, holoi ʻia me kahi aniani o ka wai. Hoʻohui pinepine ʻia - 1 manawa i kēlā me kēia lā.

No ka hapa nui o nā maʻi, ʻo ka hoʻomaka a me ka mālama mālama ʻia he 50 mg hoʻokahi i kēlā me kēia lā. Loaʻa ka hopena antihypertensive kiʻekiʻe i loko o ʻekolu a ʻeono mau pule ma hope o ka hoʻomaka ʻana o ka hoʻomaʻamaʻa.

Pono kekahi mau maʻi e hoʻonui i kahi dosis a hiki i 100 mg hoʻokahi i ka lā (i ke kakahiaka).

Nā hypertension arterial i nā maʻi me ka diabetes mellitus type II me ka proteinuria ≥ 0,5 g / lā

ʻO ka papa hoʻomaka hoʻomaka ma 50 mg hoʻokahi i kēlā me kēia lā. Hiki ke hoʻonui ʻia ka nui o ka dosage i ka 100 mg hoʻokahi i ka lā ma ke kau o nā hopena o ke koko i ka mahina ma hope o ka hoʻomaka ʻana o ka mālama ʻana. Hiki ke lawe ʻia i Losartan me nā ʻaina antihypertensive ʻē aʻe (e. G diuretics, blockers o ka kalima, alpha a i ʻole beta a me nā mea kikowaena waena) a me nā insulin a me nā mea hou e hoʻohana ʻia ana i mau ʻano hypoglycemic maʻamau (e.g. sulfonylurea, glitazone, inhibitor glucosidase) . ^ E Ha yM.

ʻO ka ʻōmua mua o Lorista® i nā maʻi me ka hōʻeha ʻole o ka naʻau he 12.5 mg i kēlā me kēia lā i kahi pākahi. I mea e hoʻokō ai i kahi mālama mālama i 50 mg i kēlā me kēia lā, maʻamau ka mea e hoʻomanawanui maikaʻi ʻia e nā mea maʻi, e hoʻonui iki ʻia ka nui o ka lāʻau lapaʻau ma o 12.5 mg, ma waena o hoʻokahi pule (i.e., 12.5 mg i kēlā me kēia lā, 25 mg pākahi, 50 mg i ka lā, 100 mg i kēlā me kēia lā, a hiki i kahi kiʻekiʻe loa o 150 mg hoʻokahi i ka lā).

ʻO nā mea maʻi me ka puʻuwai puʻuwai e kūpaʻa kona kūlana me ka hoʻohana ʻana o kahi inhibce ACE ʻaʻole pono e neʻe i ka mālama losartan.

Hoʻemi ka hopenahoʻomohalaʻeha i nā maʻi maʻi me nā hypertensionahypertrophy o ka hemaua hōʻoia ʻia ʻo ventriclethECG.

ʻO ka dosis hoʻomaka ʻana he 50 mg o losartan hoʻokahi i ka lā. Hiki ke hoʻohui ʻia i kahi haʻahaʻa haʻahaʻa o ka hydrochlorothiazide a me / a i ʻole e hoʻonui ʻia i loko ka 100 mg i kēlā me kēia lā e pili ana i nā hopena koko.

Lapaʻau lāʻau

ʻO Lorista ® N kahi hui pūʻokoʻa nona ka mau ʻāpana hoʻohui me ka hopena hypotensive a ma kahi o ke ʻano o ka hoʻohaʻahaʻa ʻana i ke kahe o ke koko i hoʻohālikelike ʻia me ko lākou hoʻohana. Ma muli o ka hopena diuretic, hoʻonui ka hydrochlorothiazide i ka hana o ka plasma renin, ʻo ka huna ʻana o ka ald testosterone, e hōʻemi ana i ka momona o ka serum a hoʻonui i ka pae o ka angiotensin II i ka plasma koko. Hāʻawi ʻo Losartan i ka hopena o ka physiological o ka angiotensin II a, ma muli o ke kaohi ʻana o ka huna ʻana o aldosterone, hiki iā ia ke waho i ka nalowale o nā papa o ka potassium i hana ʻia e kahi diuretic.

Loaʻa iā Losartan kahi hopena uricosuric. Hoʻopilikia ka Hydrochlorothiazide i ka hoʻonuiʻana i ka hoʻoliʻiliʻi o ka waikika uric, me ka hoʻohana ʻana o ka losartan i ka manawa like me ka hydrochlorothiazide, hyperuricemia i hōʻemi ʻia e ka diuretic hoʻoemi.

ʻO ka hopena antihypertensive o ka hui hydrochlorothiazide / losartan e hoʻomau nei no nā hola 24. ʻOiai naʻe ke emi nui i ke kahe o ke koko, ʻaʻole ka hoʻohana ʻana i ka hopena hydrochlorothiazide / losartan i ka hopena nui o ka naʻau i ka hōʻeha o ka puʻuwai.

ʻO ka hui pū ʻana o ka hydrochlorothiazide / losartan e hana pono ana i nā kāne a me nā wahine, a me nā mea maʻi ma ka ʻōpio o ʻōpio (ʻōpio ma mua o 65 mau makahiki) a me nā ʻelemakule (mai 65 mau makahiki a ʻoi aku).

ʻO Losartan kahi mea hoʻopaleʻaleʻa o ka ʻāmaʻomaʻi o ka angiotensin II no ka hoʻokūkū waha no kahi ʻano wai ʻole nui. ʻO Angiotensin II kahi ʻano nui o ka vasoconstrictor a me ka hormone nui o RAAS. Hoʻopili ʻo Angiotensin II i nā ʻĀkapa AT 1, ka mea i loaʻa i loko o nā kikoʻehā (e.g., kūlohelohe o nā kīʻaha koko, nā puʻu adrenal, ʻōpū a me myocardium) a me ka hoʻopuka i nā hopena kūlohelohe o ka angiotensin II, e komo pū ana me vasoconstriction a me ka hoʻokuʻu ald testosterone. Eia kekahi, hoʻowalewale ka angiotensin II i ka hoʻomaikaʻi ʻana i nā ʻoi mākia o nā pelu polū.

Hoʻopili paʻa ʻia ʻo Losartan i nā ʻĀkela ʻimi. Ke vivo a i loko o vitro losartan a me kāna hana biologically hoʻoikaika o ka carboxy metabolite (EXP-3174) ālai i nā hopena koʻikoʻi pili kino o ka angiotensin II ma nā ʻae ʻana mai AT 1, me ka mea o ke ala o kāna synt synt. ʻAʻohe o kahi agonism o Losartan a ke kāohi ʻole nei i nā ʻae a me nā mea i hoʻonaʻauao nui i ka nui o ke hoʻoponopono ʻana i ka CCC. ʻAʻole ʻo Losartan i kāohi i ka hana o ACE (kininase II), he enzyme i pili i ka metabolism o ka bradykinin. Me ke kumu, ʻaʻole ia e hoʻonā i ka nui o nā hopena kūpono ʻole i hoʻopili ʻia e ka bradykinin.

Hoʻokomo ʻole ʻo Losartan i ka hoʻolaʻa ʻana o ka mea hōʻea o AT 2 ma ka hoʻonui ʻana i ka pae o ka angiotensin II ma ke koko koko.

ʻO ka hana ʻana i ka hoʻoponopono o ka loiloi o ka ʻona i hana ʻia e ka angensensin II e ka hoʻokūkū pane maikaʻi ʻole i ka wā o ka mālama ʻana me ka losartan e hoʻoulu ai i ka hana ʻo renin ka hana, ka mea e alakaʻi ai i ka hoʻonui o ka konsiot anginensin II i loko o ke kaila koko. Eia nō naʻe, ʻo ka hopena antihypertensive a me ke kaohi ʻana o ka sekela aldosterone ka hoʻomau ʻana, e hōʻike ana i kahi paʻa kūpono o ka ʻono e kū nei nā angiotensin II.Ma hope o ka hoʻopauʻana i ka losartan, ka hana renin plasma a me ka paʻa ʻana o ka angiotensin II i ka emi ʻana o nā kumu mua i loko o 3 mau lā.

ʻO Losartan a me kāna metabolite koʻikoʻi ikaika i kahi pilina kiʻekiʻe loa no nā mea hoʻokipa AT 1 i hoʻohālikelike ʻia i nā ʻaeʻaʻi AT 2. Loaʻa ka metabolite koʻikoʻi i ka losartan ma ka hana ma o 10 mau manawa.

Hoʻohālikelike ʻia ka pinepine o ka hoʻomohala ʻana ma ka wā e hoʻohana ai i ka losartan a i kahi hydrochlorothiazide a haʻahaʻa loa ʻia ma mua o ka hoʻohana ʻana i kahi inhibitor ACE.

I nā mea maʻi me ka maʻi hypertension a me ka proteinuria, ʻaʻole i ʻeha ʻia me ka maʻi mellitus, hoʻomaʻamaʻa ʻia me ka losartan e hoʻemi nui i ka proteinuria, ka ʻoihana o albumin a me IgG. Kākoʻo ʻo Losartan i ka kānana glomerular a hōʻemi i ka hapa filtration. Hoʻopau ʻo Losartan i ka hoʻoliʻiliʻi o ka serum uric acid (ma lalo aʻe o 0.4 mg / dl) ma o ka papa o ka hopena. ʻAʻohe mea i hopena ʻo Losartan i nā reflex autonomic a ʻaʻole i hoʻopilikia i ka ʻike o norepinephrine i ka pulu koko.

I ka poʻe maʻi me ka hapa o ka ventricular hema, ʻo losartan i nā helu o ka 25 a me 50 mg ke loaʻa i ka hopena hemodynamic maikaʻi a me ka neurohumoral, ke ʻano o ka hoʻonui ʻana i ka pākuhi puʻuwai a me ka hoʻolilo ʻana i ke kaomi o ka honi pulillary pulillary, OPSS, i ke ʻano o ke koko a me ka puʻuwai puʻuwai a me ke kahe ʻana o ka komo ʻana o ka plasma o aldosterone a me norepinephrine. ʻO ka hopena o ka hoʻomohalaʻana i ka hypotension arterial i nā maʻi me ka hōʻeha ʻana o ka naʻau ma muli o ka nui o ka losartan.

ʻO ka hoʻohana ʻana o losartan i hoʻokahi lā i ka poʻe maʻi me nā maʻi hypertension kūpono e hōʻemi i ka nui o ka SBP a me DBP. Pono ka hopena antihypertensive no nā hola 24 e mālama ana i ke kuapoʻo circadian kūlohelohe o ke koko. ʻO ka pae o ka hōʻemi ʻana i ke koko i ka hopena o ka waʻa dosing he 70-80% hoʻohālikelike ʻia me ka hopena hypotensive i nā hola 5-6 ma hope o ka lawe ʻana i ka losartan.

Maikaʻi ʻo Losartan i nā kāne a me nā wahine, ʻo ia nō hoʻi i nā poʻe maʻi ʻelemakule (65 mau makahiki a ʻoi aku) a me nā mea maʻi ʻōpio (ma lalo o 65 mau makahiki o ko lākou makahiki). ʻO ka hoʻoneʻe ʻana o ka losartan i nā mea maʻi me ka hypertension arterial ʻaʻole ia e alakaʻi i ka piʻi nui o ke kahe koko (ʻaʻohe no ka haʻalele ʻana o ka lāʻau lapaʻau). ʻAʻole kahi hopena o Losartan i ka hopena o ka puʻuwai puʻuwai.

Thiazide diuretic, ka hopena o ka hopena hypotensive i hoʻopaʻa ʻole ʻia. Hoʻololi ʻo Thiazides i ka reabsorption o nā electrolytes i ka nephron mamao a hoʻonui i ka hoʻonui ʻana o ka sodium a me nā klorinine e like me ka like. Hoʻonui ka hopena diuretic o ka hydrochlorothiazide i ka hoʻohaʻahaʻa i ka bcc, kahi hoʻonui i ka hana renin plasma a me ka huna ald testosterone, ka mea e hoʻonui ai i ka hoʻonui ʻana o nā paʻakai me nā bicarbonates e nā kuli a me kahi hoʻēmi ʻana i ka ʻikepala sima. Hoʻohui ʻia ka pilina ma waena o ka renin a me ka ald testosterone e ka angiotensin II, no laila ke hoʻohana pū ʻia nei ʻo ARA II e hōʻalo i ka lilo o nā papa o ka potassium i ka loaʻa ʻana o ka diuretics thiazide.

Ma hope o ka lawelawe waha, ua kūpono ka hopena diuretic ma hope o 2 mau hola, a hiki i kahi lōʻihi ma hope o ka hola 4 mau a lōʻihi no ka mau hola 6-12, e hoʻomau ka hopena hypotensive no 24 mau hola.

Lapaʻau lāʻau

ʻO nā pharmacokinetics o losartan a me hydrochlorothiazide aʻo ke ka lawe ʻana, ʻaʻole ia i ʻokoʻa mai ka manawa i hoʻohana pinepine ʻia lākou.

Kapehu. Losartan: ma hope o ka lawelawe waha, ua hoʻopili maikaʻi ʻia ka losartan a hoʻoneʻe i ka wā o ka hele mua ma o ka ate me ka hoʻokumu ʻana o ka metabolite carboxy hoʻoikaika (EXP-3174) a me nā metabolite hana ʻole. ʻO ka bioavailability o ka ʻōnaehana ma kahi o 33%. C max i loko o ke kaila koko o losartan a me kāna metabolite ikaika e loaʻa ana ma hope o 1 h a me nā hola 3-4, kēlā me kēia. ʻO Hydrochlorothiazide: ma hope o ka hoʻopale ʻana i ka waha, ʻo ka hoʻopili ʻana o ka hydrochlorothiazide he 60-80%. C max o ka hydrochlorothiazide i loko o ke koko koko e loaʻa ana i kahi o 1-5 mau hola ma hope o ke kauā ʻana.

Kahele. Losartan: ʻoi aku ma mua o 99% o losartan a me EXP-3174 e hoʻopili ai i nā protein plasma, ʻoi aku me ka albumin. ʻO V d o losartan he 34 lita. E komo pū ana i loko o ka BBB. Hydrochlorothiazide: kamaʻilio pū me nā protein plasma he 64%, kākaʻi i ka placenta, akā ʻaʻole ma o BBB, a lawe ʻia i ka waiū umauma.

ʻO Biotransformation. Losartan: kahi kokoke i 14% o kahi make o losartan, lawelawe iv a me nā mea maʻamau, ua hoʻohiolo ʻia e hana i kahi metabolite ikaika. Ma hope o ka hoʻoponopono waha a me / a iv mea hoʻomalu o 14 C-losartan potassium, ua hoʻoholo mua ʻia ka radioactivity o ka pilina koko i ka losartan a me kāna metabolite hoʻoikaika.

I ka hoʻohui ʻana i nā metabolite ikaika, ua hoʻokumu ʻia nā metabolite ʻoi aku, me ka ʻelua o nā metabolites nui i hoʻomohala ʻia e ka hydroxylation o nā butyl hui o ke kaulahao, a me ka metabolite liʻiliʻi - N-2-tetrazole glucuronide.

ʻO ka lawe ʻana i ka lāʻau me ka meaʻai, ʻaʻohe hopena koʻikoʻi ʻoi loa e pili ana i ka serum.

ʻO Hydrochlorothiazide: ʻaʻole i hoʻohuihui ʻia.

Leʻaleʻa. Losartan: ʻo ka wehe ʻana i ka plasma o losartan a me kāna metabolite hoʻoikaika ʻehā he 600 a me 50 ml / min, ma kēlā me kēia, a me ka wehe ʻana o ka renal o ka losartan a me kāna metabolite hoʻōla he 74 a 26 ml / min, ma kēlā. Ma hope o ka lawelawe waha, ua wehe wale ʻia ʻo 4% o nā nui i lawe ʻia e nā ʻōpū a me kahi kokoke i 6% ma ke ʻano o ka metabolite hoʻoikaika. ʻO ka laila ʻo pharmacokinetic o losartan a me kāna hana metabolite i ka wā e lawe ai i ka waha (i nā dosis a hiki i 200 mg) ka laina.

T 1/2 ma ka pae manawa o ka losartan a me ka metabolite ikaika e 2 mau hola a he 6-9 mau hola, kēlā. ʻAʻohe ʻōmole o losartan a me kāna metabolite hoʻoikaika i ka wā i hoʻohana ʻia ma kahi ʻano o 100 mg hoʻokahi i kēlā me kēia lā.

Hoʻokuʻu ʻia ia ma nā ʻili ma ka ʻili - 58%, ʻehā - 35%.

Hydrochlorothiazide: ua hoʻonui wikiwiki ʻia e nā keiki. ʻO T 1/2 o 5.6-14.8 mau hola.E pili ana i ka 61% o ka nui ma ka lawaiʻa a hoʻololi ʻia.

ʻO nā hui maʻi maʻi kūloko

Hydrochlorothiazide / losartan. ʻO ka hoʻoliʻi Plasma o losartan a me kāna metabolite hoʻoikaika a me hydrochlorothiazide i nā poʻe maʻi me nā hypertension arterial ʻaʻole i hoʻokaʻawale ʻē aʻe i kēlā mau mea maʻi.

Losartan. I nā mea maʻi me ka hoʻōho a me ka hoʻohaʻahaʻa kino ʻana i ka pika ma hope o ka hoʻopale waha ʻana i ka losartan, ʻo ka ʻike ʻana o ka losartan a me ka metabolite ikaika i loko o ke koko koko he 5 a me 1,7 mau manawa i ʻoi aku ma mua o nā kānaka ʻōpio kāne ʻōpiopio.

ʻAʻole i hoʻoneʻe ʻia ka Losartan a me kāna metabolite hoʻoikaika e ka hemodialysis.

ʻŌpū a me ka lactation

ʻAʻole hoʻohana ʻia ka hoʻohana ʻana o ARA II i ka trimester mua o ka'ōpū.

ʻAʻole pono e hoʻohana ʻia ka lāʻau lapaʻau Lorista ® N i ka wā hapai, me ka wahine hoʻi e hoʻolālā ana i ka hāpai ʻana. Ke hoʻolālā nei i ka wā hapai, ua ʻōlelo ʻia e neʻe ka mea maʻi i ka terapi antihypertensive hou e mālama ana i ka ʻike palekana. Inā hoʻopaʻa ʻia ka wā lohi, e kāpae i ka lawe ʻana iā Lorista ® N a, inā pono, e hoʻokaʻawale i ka mea maʻi i ka anti antihypertensive therapy.

ʻO ka lāʻau ʻomaʻo Lorista ® N, e like me nā lāʻau lapaʻau hou e loaʻa ai ka hopena i ke keaka o RAAS, hiki ke hōʻeha i nā hopena kūpono ʻole i ka ʻōpio (hana renal functioning, lohi i ka pīpī o nā iwi o ka ʻōpala, oligohamoamnios) a me nā hopena ʻona o ka neonatal (renal gagal, hypotension arterial, hyperkalemia). Inā ʻoe ke hoʻohana ʻana i ka lāʻau lapaʻau Lorista ® N i loko o ka trimesters II-III o ka hapai, pono e hoʻokō i kahi ultrasound o nā akeʻa a me nā iwi o ka ʻōpiopio.

Hoʻopaʻi ka Hydrochlorothiazide i ka plasenta. Ke hoʻohana ʻia nei ka diuret thiazide i ka trimester II o III o ka hapai, heʻano hoʻokaʻawa i ke kahe koko-utero-placental, ka hoʻomohala ʻana o ka thrombocytopenia, kaipoole, a me ka haunaele ʻana i ka lilo ʻana o ka wai-electrolyte i loko o ka wahine hāpai a i ʻole ka pēpē.

ʻAʻole pono e hoʻohana ʻia ʻo Hydrochlorothiazide e mālama i ka maʻi gestosis i ka lua o ka hapalua (edema, hypertension arterial a preeclampsia (nephropathy)) ma muli o ka hopena o ka hoʻohaʻahaʻa i ka bcc a me ka hoʻohaʻahaʻa ʻana i ke kahe koko uteroplacental i ka lilo ʻana o kahi hopena maikaʻi i ka papa o ka maʻi. ʻAʻole hoʻohana ʻia ka Hydrochlorothiazide e mālama i ka hypertension koʻikoʻi i loko o nā wahine hāpai, me kaʻole o nā hihia loaʻa ʻole i hiki ke hoʻohana ʻia nā mea ʻē aʻe.

ʻO nā pēpē i hāpai ʻia a ko lākou mau makuahine iā Lorista ® N i ka wā hapai, e mālama ʻia hiki paha ke ulu ʻana i ka hypotension arterial i ka pēpē.

ʻAʻole i ʻike ʻia a excreted a losartan me ka umauma waiū.

Hele ka Hydrochlorothiazide i loko o ka waiū makuahine a ka liʻiliʻi ma ka liʻiliʻi. Thaizide diuretics ma nā kiʻina nui e kumu ai i ka diuresis ikaika, a laila hoʻowalewale i ka lactation.

Nā hopena hopena

Ka papa kuhikuhi ʻana i ka loaʻa ʻana o nā hopena ʻokoʻa o ka ʻĀina:

pinepine mau ≥1 / 10, pinepine mai ≥1 / 100 a me QT (pilikia o ka hoʻomohala ʻana i ka tachycardia ventricular o ka ʻano pirouette),

Nā papa IA IA o nā lāʻau lapaʻau antiarrhythmic (e. G. Quinidine, disopyramide),

Class III antiarrhythmic drug (e.g. amiodarone, sotalol, dofetilide).

ʻO kekahi mau antipsychotics (no ka laʻana, thioridazine, chlorpromazine, levomepromazine, trifluoperazin, sulpiride, amisulpride, setiapride, haloperidol, droperidol).

ʻO nā lāʻau'ē aʻe (e.g. cisapride, diphenyl methyl sulphate, erythromycin no ka administrima iv, halofantrine, ketanserin, misolastine, sparfloxacin, terfenadine, vincamine no ka hoʻomalu iv).

ʻO ka Vitamin D a me ka paʻakai kalima: ʻo ka hoʻohana like ʻana o ka diuretics thiazide me ka vitamina D a i ʻole ka paʻakai calcium e hoʻonui i ka momona o ka serum calcium, ʻoiai kapili ʻaila. Inā makemake ʻoe e hoʻohana i ka hoʻomākaukau o ka calcium a i ka vitamin D paha, pono ʻoe e nānā i ka ʻike o ka calcium ma ka serum koko a, aia paha, e hoʻoponopono i ka ʻano o kēia mau lāʻau.

Carbamazepine: pilikia o ka hoʻouluʻana i ka hyponatremia hōʻailona. Pono e kāohi i nā ʻōkuhi a me nā ʻōlima.

Hiki i ka Hydrochlorothiazide ke hoʻonui i ka hopena o ka hoʻomohala ʻana i ka hana ʻole i ka maʻi renal, ʻoiai me ka hoʻohana pū ʻana o nā ʻāpana kiʻekiʻe o nā iodine e hoʻopili ʻia ana. Ma mua o ka hoʻohana ʻana iā lākou, pono ia e hoʻihoʻi i ka bcc.

Amphotericin B (no ka hoʻokele intravenous), hoʻopuka laxatives a i ʻole ammonium glycyrrhizinate (ʻāpana o ka licorice): hiki i ka hydrochlorothiazide ke hoʻonui i ka hoʻōla wai-electrolyte, ʻoi aku hoʻi ka hypokalemia.

Ke keu

ʻAʻohe ʻike e pili ana i ka overdose o ka hui hydrochlorothiazide / losartan.

Lāʻau: therapy a me ka maʻi kākoʻo. Pono e hoʻoneʻe ʻia ʻo Lorista ® N a nānā pono ka mea maʻi. Inā pono: e hoʻoulu i ka luaʻi (inā ua lawe hou ka mea maʻi i ka lāʻau lapaʻau), hoʻohui i ka bcc, ka hoʻoponopono ʻana i nā hūnā ma ka hoʻoliʻi wai-electrolyte a me kahi hoʻokaʻina i hōʻailona ʻia i ke koko.

Losartan (palena waiwai)

Nā Hoʻomaka hōʻailona hōʻemi i ke koko, tachycardia, bradycardia ma muli o ka hoʻonani parasympathetic (vagal) hiki.

Lāʻau: therapy maʻi maʻi maʻi, hemodialysis hiki ole.

Nā Hoʻomaka nā hōʻailona maʻamau loa: hypokalemia, hypochloremia, hyponatremia a me ka hiʻona, ma ka hopena o ka diuresis nui. Me ka hoʻomohala pinepine ʻana o nā glycosides cardiac, hiki i ka hypokalemia ke hoʻonāukiuki i ka papa o nā arrhythmias.

Nā ʻōlelo kikoʻī

ʻO ka edema Angioneurotic. ʻO ka poʻe maʻi me ka angioedema (alohe, lehelehe, pharynx, a me / a larynx paha) e nānā pono pono ai i kekahi mōʻaukala.

Hypotension arterial a me hypovolemia (dehydration). I ka poʻe maʻi me ka hypovolemia (dehydration) a me / a i ʻole kahi hōʻemi sodium i hōʻemi ʻia i loko o ke koko i ka wā o ka diuretic therapy, ʻohi ʻana i ka paʻakai o ka paʻakai, ʻehaʻeha, a i ʻole luhi paha, hypotension hypotension e ulu, ʻoiai ma hope o ka lawe ʻana i ka hopena mua o Lorista ® N. Ma mua o ka hoʻohana ʻana i ka lāʻau, pono e hoʻihoʻi ʻia. Kūʻai ʻo BCC a me / o ka sodium i loko o ka plasma.

Haki i ka pae wai-electrolyte kaulike. ʻO nā hewaʻole o ka hoʻāla wai-electrolyte i ʻike pinepine ʻia i nā mea maʻi i nā hana ʻoi aku ka hopena o ka renal, ʻoi aku hoʻi i ka maʻi mellitus maʻi diabetes. I kēia mea, pono ia e nānā pono me ka nānā o ka paʻakai ma ka pili koko a me ke kīlei creatinine, keu i nā mea maʻi me ka naʻau puʻuwai a me Cl creatinine 30-50 ml / min.

Hoʻohana ʻia ka manawa like me ka potassium-sparing diuretics, hoʻomākaukau i ka paʻakai, nā paʻakai paʻakai i loko o ka paʻakai, a i ʻole nā ʻano e hiki ke hoʻonui i ka ʻomo o ka pāima ma loko o ke koko plasma (e.g. heparin) ʻaʻole i ʻōlelo ʻia.

Hōʻeha ka naʻau ʻili. Hoʻonui nui ka nānā ʻana o ka losartan i loko o ke koko koko i nā mea maʻi me ka cirrhosis, no laila, pono e hoʻohana ʻia ka lāʻau lapaʻau Lorista ® N me ka makaʻala i nā mea maʻi me ka hana maʻalahi ʻoluʻolu a me ka palaualelo.

Hola paʻa kino hana. ʻO ka hana renal hiki ʻole ke kau ʻia, ʻo ka hoʻololi ʻole ʻana o ka renas, ma muli o ka pale ʻana i ka hoʻopiʻi ʻana o RAAS (ka mea nui i nā poʻe maʻi e pili ana i ka hana renal ma RAAS, no ka laʻana, me ka ʻeha ʻole o ka naʻau a i ʻole kahi mōʻaukala o ka renal)

ʻO ka stenosis aʻa Renal. I ka maʻi me ka bilateral renal stenosis stenosis, me ka stenosis arterial o ke kino wale nō ka hana e hana ana, ka lāʻau lapaʻau e hoʻopili ai iā RAAS, e komo pū ana a me ARA II, hiki i ka mea hou ke hoʻonui i ka ʻike o ka urea a me ka kumu hana i loko o ke koko koko.

Pono e hoʻohana ʻia ʻo Losartan me ka akahele i nā poʻe maʻi me ka stenosis aralula renalula a i ʻole he stenosis keiki ʻole.

Nā keiki hele liʻiliʻi. ʻAʻoheʻike i loaʻa me ka hoʻohana ʻana o Lorista ® N i nā mea maʻi i hōʻeha hou i ka hiki ke hoʻololi i ka kidney.

ʻO ka hyperaldosteronism mua. ʻO nā maʻi me ka hyperaldosteronism maʻamau e kūpaʻa i nā lāʻau antihypertensive e pili ana i ka RAAS, no laila, ʻaʻole i hāʻawi ʻia ka hoʻohana ʻana o Lorista ® N i nā mea maʻi.

Nā maʻi IHD a me nā maʻi cerebrovascular. E like me kekahi lāʻau antihypertensive, ʻo ka hoʻemi nui ʻana o ke kahe koko i loko o nā poʻe maʻi me ka maʻi artery coronary i ʻole a me nā maʻi cerebrovascular hiki ke alakaʻi i ka hoʻomohala ʻana i ka maʻi myocardial or stroke.

Haki puʻuwai. I nā maʻi e pili ana i ka hana renal i ka mokuʻāina ʻo RAAS (no ka laʻana, kahi papa hana NYHA ʻano III III-IV CHF, me ka ʻole ʻole o ka hōʻino kino ʻole), ʻo ka maʻi me nā lāʻau e pili ana iā RAAS e hele pū me ka hypotension arterial koʻikoʻi, oliguria a / a i ʻole ka holomua azotemia, i nā hihia pinepine, hoʻonā i nā pilikia renal. ʻAʻole hiki ke haʻalele i ka holo ʻana o kēia mau pilikia ma muli o ka hoʻopiʻi ʻana i ka hana o RAAS me ARA II.

ʻO ka Stenosis o ka aortic a me / a i kahi valle mitral, GOKMP. ʻO ka lāʻau lapaʻau Lorista ® N, e like me nā vasodilator e pono ai, e hoʻohana pono me ka akahele i ka poʻe maʻi me ka stodyosis hemodynamically koʻikoʻi o ka aortic a / a i ʻole valle mitral, a i ʻole GOKMP.

Nā hiʻohiʻona moʻomeheu. ʻO Losartan (e like me nā lāʻau lapaʻau ʻē aʻe e pili ana i ka RAAS) ka hopena hypotensive liʻiliʻi i haʻi aku i nā poʻe maʻi o ka lāhui Negroid i hoʻohālikelike ʻia me nā ʻelele o nā lāhui ʻē aʻe, aia paha ma muli o ke kiʻekiʻe o ka hyporeninemia i kēia mau maʻi me ka hypertension arterial.

Hypotension arterial a me ka hoʻopiha wai-electrolyte metabolism. Pono e kāohi i ke koko, nā hōʻailona kulekele o nā metabolism mea hoʻopiha wai-electrolyte, ʻo ia hoʻi dehydration, hyponatremia, hypochloremic alkalosis, hypomagnesemia a i ʻole hypokalemia, hiki ke ulu i ke kūkaʻe o ke kīwaha a i ʻole luaʻi.

ʻO nā electrolytes serum pono e nānā ponoʻia i kēlā me kēia manawa.

Nā hopena metabolic a me ka endocrine. Pono e mālama ʻia i nā maʻi āpau e loaʻa ana ka mālama ʻana me nā ʻaihue hypoglycemic no ka hoʻopale waha a i ʻole insulin, no ka mea Hiki i ka hydrochlorothiazide ke nawaliwali i ka hopena. I ka wā maʻi me ka diuret thiazide, hiki i ka maʻi diabetes mellitus ke hōʻike.

ʻO ka diuret Thiazide, me ka hydrochlorothiazide, hiki ke hoʻonāukiuki i ka ʻohi wai-electrolyte (hypercalcemia, hypokalemia, hyponatremia, hypomagnesemia, a me hypokalemic alkalosis).

Hiki i ka diuret Thiazide ke hōʻemi i ka excretion o ka calcium e nā keiki a mālama i kahi hoʻonui iki a me ka liʻiliʻi o ka calcium i ka plasma koko.

ʻO ka hypercalcemia koʻikoʻi paha kahi hōʻailona o ka hyperparathyroidism latent. Ma mua o ka hoʻokau ʻana i ka noiʻi o nā hana o nā kūlima parathyroid, pono ke kāpae ʻia ka thaizide diuretics.

E kūʻē i ka mua o ka mālama ʻana me ka diuretics thiazide, hiki ke hoʻonui ʻia i ka neʻe ʻana o ka cholesterol a me ka triglycerides i ka serum koko.

Thiazide diuretic therapy ma kekahi mau mea maʻi e hoʻohilahila i ka hyperuricemia a me / a hoʻomaikaʻi ʻana i ke ʻano o ka gout.

Hoʻololi ʻo Losartan i ka hoʻohuihui ʻana o ka waikik uric i ka plasma koko, no laila, ʻo kona hoʻohana ʻana me ka hui pū ʻana me ka pae hydrochlorothiazide e pili ana i ka diuretic thiazide.

Hōʻeha ka naʻau ʻili. Pono e hoʻohana ʻia ʻo Diuretics Thiazide me ka makaʻala i nā poʻe maʻi me ka hana o ka puʻuwai maʻi a i ʻole ka holo ʻana o ka maʻi ʻōmaʻomaʻo, no ka mea hiki iā lākou ke hōʻeha i ka cholestasis intrahepatic, a hiki i nā mea hōʻemi i ka wai-hoʻoliʻoli wai hiki ke hoʻopuka i ka hoʻomohala ʻana i ka comp.

ʻO ka lāʻau Lorista ® N ka hoʻohālikelike ʻia i nā maʻi me nā maʻi ʻehaʻeha ohaʻi, no ka mea ʻaʻoheʻike me ka hoʻohana o ka lāʻau lapaʻau i kēia māhele o nā maʻi.

Kaila myopia a me ke aniani ākea paʻa kīkaha. ʻO ka Hydrochlorothiazide kahi sulfonamide e hiki ai ke hana i kahi hopena idiosyncratic e alakaʻi i ka hoʻomohala ʻana i ka myopia a transient a me kahi aniani koki-kokoke. Pākuʻi ʻia nā ʻōmaʻomaʻi: kahi hōʻemi wikiwiki e ʻike i ka acuity ʻike a i ʻole ka nānā ʻana o ka maka, e ʻike pinepine ʻia i loko o kekahi mau hola a i hoʻokahi pule paha mai ka hoʻomaka ʻana o ka maʻi hydrochlorothiazide. Hōʻalo ʻia ka hema, ʻaʻa kohi-kūpaʻa hiki ke alakaʻi i ka hoʻoilo mau ʻana o ka ʻike.

Lāʻau: oki e lawe i ka hydrochlorothiazide i ka hiki. Inā hoʻomau ʻole ka IOP, pono e nānā ʻia ka lāʻau lapaʻau i ʻole. ʻO nā mea pilikia no ka hoʻomohala ʻana i ke aniani glamcoma ʻoi aku: ka mōʻaukala o kahi hopena aler i ka sulfonamide a i ʻole benzylpenicillin.

I nā mea maʻi e lawe ana i ka diuret thiazide, hiki i nā hopena hypersensitivity ke ulu a kū i ka mua a me ka ʻole o ka mōʻaukala o kahi hopena alaka a i ʻole ka palaka bronchial, akā ʻoi aku ka nui o lākou inā he mōʻaukala lākou.

Aia nā hopena o ka hoʻonāukiuki o ka systemus lupus erythematosus i ka wā o ka hoʻohana ʻana o ka diuretics thiazide.

ʻO kaʻikepili kūikawā ma nā mea kūʻai aku

ʻO ka lālani Lorista ® N he lactose, no laila ke hoʻomau nei ka lāʻau i nā mea maʻi me ka nele o ka lactase, ka lactose intolerance, glucose-galactose malabsorption syndrome.

Ka hopena i ka hiki ke hana i nā hana hanana pōʻino e pono ai ka nānā kūikawā a me ke ʻano wikiwiki (e like me ke kime, ka holo ʻana, e hana ana me nā ʻōnaehana neʻe). I ka hoʻomaka ʻana o ka ho'ōla, hiki i ka lāʻau laʻa Lorista ® N ke hōʻeha i kahi kahe o ke koko, ke ʻole a me ka hiamoe, a no laila ke kūleʻa pinepine nei i ka kūlana psycho-emotional. No nā kumu palekana, ma mua o ka hoʻomaka ʻana i kahi hana e koi ai i ka nānā nui ʻana, pono mua ka poʻe maʻi e loiloi i kā lākou pane i ka hana.

ʻAno lāʻau

Loaʻa ka lāʻau lapaʻau "Lorista" i nā ʻano like ʻole: ma ke ʻano o ka hoʻomākaukau ʻana i hoʻokahi māhele "Lorista", i hoʻohui ʻia nā ʻano o "Lorista N" a me "Lorista ND", i ʻokoʻa i ka hopena o nā mea ikaika. Loaʻa nā ʻaoʻao ʻelua o ka lāʻau i ka hopena antihypertensive a loaʻa kahi hopena diuretic.

Loaʻa nā papa papa ʻaina Lorista i ka papa hana hoʻokahi i loko o ʻekolu mau huina e loaʻa ai ka ʻano hana ikaika o ka pāhare losartan 12.5 mg, 25 mg, 50 mg pākahi. E like me nā mea kōkua, ka palaoa a me ka pregelatinized starch, kahi hui ʻana o ka waiū waiū me ka cellulose, aerosil, magnesium stearate e hoʻohana ʻia. ʻO ka membrane kiʻiʻoniʻoni o nā dosage o 25 mg a 50 mg o ka potassium losartan ka mea o ka hypromellose, talc, propylene glycol, titanium dioxide, a me kahi wai melemele quinoline i hoʻohana pū ʻia no kahi mahele o 12,5 mg.

Hōʻike ʻia nā papa o Lorista N a me Lorista ND i kahi kumu a me kahi mea hōʻemi. ʻO ka mea nui ka ʻelua mau mahele ikaika: potassium losartan 50 mg kēlā me kēia (no ka ʻano N) a me 100 mg (no ka ʻano N) a me ka hydrochlorothiazide 12.5 mg (no ka ʻano "N") a me 25 mg (no ka ʻano "N"). No ka hoʻokumuʻana o ka lula, ua hoʻohana ʻia nā mea hoʻohui ʻē aʻe ma ke ʻano o ke kōpaʻa pregelatinized, cellulose microcrystalline, kōmole waiū, stearate magnesium.

Hoʻopili ʻia nā papa ʻĀkau o Lorista N a me Lorista ND me kahi pani kiʻi ʻoniʻawe e pili ana i ka hypromellose, macrogol 4000, ka pulu melemele quinoline, nā titanium dioxide a me ka talc.

Pehea e hana ai ka lāʻau lapaʻau?

ʻO ka hui hoʻohui antihypertensive (ʻo Lorista ka lāʻau) e wehewehe i nā ʻōkuhi no ka hana lāʻau lapaʻau o kēlā me kēia mahele.

ʻO kekahi o nā mea hana e pau ai ka losartan, ka mea e hoʻohana ai me ka ʻoi i ke anagonist koho o ka ʻano kaiotiotinin enzyme 2 ma nā ʻaleʻa ʻole-protein.

Ua hōʻike ʻia ka vitro a me nā haʻawina holoholona i ka hana a losartan a me kāna metabolbox carboxyl e kuhikuhi ana i ka pale ʻana i nā hopena o ka angiotensin ma luna o ka mea hoʻonaninau ʻano 1 kaiotensin. Hoʻopau kēia i ka renin i loko o ka kaila koko a hana i ka hoʻokaʻawale ʻana i ke kao o ka aldosterone i loko o ka serum koko.

Ke kumu o ka hoʻonui ʻana i ka ʻike o ka angiotensin ʻano 2, hoʻonanea ka losartan i nā ʻenehana o kēia enzyme, ʻo ka manawa like ʻaʻole ia e hoʻololi i ka hana o ke ʻano kininase type 2 i komo i ka metabolism o ka bradykinin.

ʻO ka hana o ka hana ikaika o ka lāʻau 'Lorista' e kuhikuhi ana i ka hoʻemi ʻana i ka pale kaua peripheral piha o ka moe vascular, ka pume ʻana i loko o nā moku o ka pīhoihoi pulmonary, afterload, a me ka hoʻolako i ka hopena diuretic.

ʻAʻole ia i ʻae ʻia i ka ulu ʻana o kahi ulu pathological i ka ʻōpū puʻuwai, hoʻonui i ka kūʻē i ka hana kino o ke kino o ke kanaka, ka mea i ʻike ʻia ai ka hina ʻana o ka puʻuwai.

ʻO ka hoʻohanaʻana i kēlā me kēia lā i kahi pākahi o losartan e hoʻoulu i ka emi mau o ka puʻu kiʻekiʻe (systolic) a me ka haʻahaʻa (diastolic) i ke koko. Iloko o ka lā, ma lalo o ka mana o kēia mau mea, e kāʻili wale ʻia ke kahe o ke koko, a me ka hopena antihypertensive e kū pū me ka ritela circadian kūlohelohe. ʻO ka emi ʻana o ke kaomi o ka hopena o ka hala o ka losartan he 80% hoʻohālikelike ʻia me ka hana kiʻekiʻe o ka hana ikaika. Me ka mālama lapaʻau ʻana, ʻaʻohe hopena o ka puʻuwai puʻuwai, a ke hoʻokō nei ʻoe i ka lawe ʻana i ka lāʻau lapaʻau, ʻaʻohe hōʻailona o ka haʻalele ʻana i ka lāʻau. ʻO kaʻoi aku o ka maikaʻi o losartan e pili i ke kino kāne a me ka wahine o nā makahiki āpau.

Ma ʻāpana o ka huina i hoʻohui ʻia, ka hana o ka hydrochlorothiazide e like me ka diuretic thiazide e pili ana i ka hoʻopili ʻana o ka chlorine, sodium, magnesium, potassium a me nā wai wai i loko o ka urine mua, e hoʻi hou i loko o ke koko koko o ka nephron kidney distal. Hoʻonui ka waiwai i ka hoʻomauʻana o ka calcium a me ka uric acid e ka ion. Hōʻike ka Hydrochlorothiazide i nā waiwai antihypertensive ma muli o ka hoʻonuiʻia o ka arterioles. Hoʻomaka ka hopena diuretic ma hope o 60-120 mau minuke, a me ka hopena diuretic loa ma ka 6 a 12 mau hola. ʻO ka hopena antihypertensive maikaʻi loa e mālama ai me ka lāʻau lapaʻau e hiki mai ana ma hope o 1 mahina.

He aha ia e hoʻohana ai i ka?

ʻO ka lāʻau "Lorista", papa, kuhikuhi no ka hoʻohana ʻana i ke hoʻohana ʻana i ka hoʻohana o:

no ka mālamaʻana i ka hypertension arterial, kahi i hōʻike ʻia ai ke kahua hui.
e hōʻemi ana i ka hopena o nā maʻi o ka pūnaehana cardiovascular a me ka helu o ka make me nā loli a me ka hoʻololi ʻana i ka loli o ka pathological.

Nā hiʻohiʻona noi

I ka wā e mālama ai me ka lāʻau lapaʻau "Lorista" (nā papa), nā ʻōkuhi no ka hoʻohana ʻana iā ʻoe e lawe pū hou i nā lāʻau antihypertensive. No nā poʻeʻelemakule, ʻaʻole pono kahi koho kūikawā o ka inea mua.

Hiki i ka hana a ka lāʻau lapaʻau ke alakaʻi i ka piʻi ʻana o ka ʻike o ka creatinine a me urea i ka serum koko o nā poʻe maʻi e loaʻa ana i ka stenosis bilateral renal stenosis a i ka stenosis artery o hoʻokahi keiki.

Ma lalo o ka mana o ka hydrochlorothiazide, hoʻonui ʻia ka hypotension, hoʻomaikaʻi ʻia ka pale o ka electrolyte, ʻike ʻia e ka hoʻokaʻawale o ka nui o ke koko i ka puna, hyponatremia, hypochloremic alkalosis, hypomagnesemia, hypokalemia. Hoʻomaopopo ka hopena o ka diuretic i ka hoʻonui ʻana i ka kolamu o ka kolamu a me ka triglycerides, ke hoʻololi ʻana i ka hoʻomanawanui o ke kino i nā kinemona glucose, e hōʻemi ana i ka hoʻōki ʻana o nā calcium calcium i ka urine, ka mea e alakaʻi ai i ka hoʻonui i ka serum koko. Hiki i ka Hydrochlorothiazide ke hoʻoulu i ka hyperuricemia a me ka gout.

ʻO ka mākaukau hui pū ʻia he kōpala waiū, kahi i hoʻonoho ʻia i nā poʻe maʻi e loaʻa ana i ka nele o ka enzyme lactase, ka loaʻa ʻana o ka galactosemia a me ka glucose a me ka galactose intolerance syndrome.

I ka wā mua o ka mālama ʻana me kahi mākia hypotensive, he hoʻohaʻahaʻa i ke kaomi a me ke kū ʻana o ka dizziness hiki, e hoʻonāukiuki i ka hana psychophysical o ke kino. No laila, nā mea maʻi e pili ana i ka hana me ka nui o ka mālama ʻana i ka wā e hoʻokuke ana i nā kaʻa kaʻa a i ʻole hoʻi i nā ʻenehana paʻakikī e hoʻoholo i ko lākou kūlana ma mua o ka hoʻomau ʻana me kā lākou hana.

JSC Krka, dd, Novo mesto he mea hana i ka lāʻau anti-hypertensive o Lorista (nā papa). Kēia huahana o kēia mea hana i kā lākou hui me ka mea hoʻomehana losartan potassium. No nā ʻano hui like, loaʻa nā lāʻau lapaʻau like ʻelua me nā ʻano hana: losartan potassium a me hydrochlorothiazide.

No Lorista, like ka analoge i nā hopena antihypertensive like a me nā hopena like. ʻO kekahi lāʻau lapaʻau ʻo ia ka lāʻau lapaʻau Kozaar, nā papa o 50 a 100 mg paha o ka potassium losertan. ʻO ka mea hana, ʻo Merck Sharp & Dome B.V. Campaign, ka Netherlands.

No nā mea i hui pū ʻia, ʻo nā mea hoʻohālike ʻo Gizaar a me Gizaar forte. ʻO ka mea hana, ʻo Merck Sharp a ʻo Dome B.V., ka Netherlands. Hoʻopili ʻia nā papa liʻiliʻi liʻiliʻi me ka pā melemele, oval, me ka hōʻailona "717" ma kekahi ʻaoʻao a me ka hōʻailona no ka hoʻokaʻawale ma kēlā ʻaoʻao, a ʻo nā pā oi nā palahalaha ka nui i kāʻei ʻia me kahi kapa kiʻi keʻokeʻo me ke ʻano ʻo 745 "ma kahi ʻaoʻao.

ʻO ka huiʻana o ka lāʻau lapaʻau "Gizaar Forte" pili i ka potassium losartan ma kahi nui o 100 mg a me hydrochlorothiazide, aia ka 12,5 mg. ʻO ka hui pūʻana o ka lāʻau "Gizaar" e pili ana i ka potassium losartan ma kahi nui o 50 mg a me ka hydrochlorothiazide, aia ka 12,5 mg.

ʻAʻole i like me ia ka lāʻau "Lorista ND", ka lāʻau lapaʻau "Gizaar forte" i ʻelua mau manawa ka nui o ka hydrochlorothiazide, a me nā kiko o ka pākaʻi losertan coincides. ʻO nā lāʻau ʻelua i ka hopena antihypertensive me kahi hopena diuretic iki.

ʻO kekahi mea hoʻohui hoʻohui ʻē aʻe ʻo ia ka lāʻau ʻo "Lozap plus" i hana ʻia e "Zentiva A.S.", Czech Republic. Loaʻa ia i ke ʻano o nā papa elongated me ka pākuʻi ma nā ʻaoʻao ʻelua i kāwele ʻia me kahi kiʻi melemele kukui. ʻO ka hoʻonohonohoʻana o ka lāʻau lapaʻau ka potoma losartan ma loko o kahi nui o 50 mg a me ka hydrochlorothiazide, nā mea he 12,5 mg.

Ke ʻano lāʻau like ʻole no Lorista N ʻo ka lāʻau lapaʻau ʻo Vazotens N, i hana ʻia e Actavis Group a.o., Iceland. Loaʻa i nāʻaoʻao ʻelua. ʻO nā papa papa ʻaina haʻahaʻa he 50 mg o losartan potassium a me 12,5 mg o ka hydrochlorothiazide, aʻo nā papa papaʻa kiʻekiʻe e loaʻa ana he 100 mg o ka pāhare losartan a me 25 mg o ka hydrochlorothiazide.

Aia nā ʻaoʻao i nā ʻōkuhi no ka hoʻohana ʻana Nā Lorists . ^ E Ha yM. Loaʻa ia ma nā ʻano like ʻole o ka lāʻau (nā papa 12.5 mg, 25 mg, 50 mg a me 100 mg, H a me ND me nā diuretic hydrochlorothiazide), a loaʻa iā ia kekahi mau analogues. Ua hōʻoia ʻia kēia loiloi e nā loea. Waiho i kāu ʻikepili e pili ana i ka hoʻohana ʻana iā Lorista, nāna e kōkua i nā malihini ʻē aʻe i ka pūnaewele. Hoʻohana ʻia ka lāʻau lapaʻau no nā maʻi like ʻole (e hōʻemi i ke kaomi ma ka hypertension arterial). He nui nā hopena o ka ʻaoʻao a me nā hiʻohiʻona o ka hoʻopili ʻana me nā mea ʻē aʻe. ʻOkoʻa nā ʻano o ka lāʻau lapaʻau no nā pākeke a me nā keiki. He paʻa i ka hoʻohana ʻana o ka lāʻau lapaʻau i ka wā hāpai a i ka wā lactation. Hiki ke kuhikuhi ʻia ka hoʻomaʻamaʻa ʻana o Lorista e kekahi kauka kūpono. Hiki i ka lōʻihi o ke olakino ke ʻano a hilinaʻi ma ka maʻi kūikawā.

Nā ʻōkuhi no ka hoʻohana a me ka helu ʻana

Lawe ʻia ka lāʻau lapaʻau ma ke ʻano, me ka mea ʻole i ka ʻai, ʻo ke alapine ʻana o ka hoʻokele - 1 manawa i kēlā me kēia lā.

ʻOiai e lawe ana i ka diuretics i nā inikini kiʻekiʻe, ke koho ʻia e hoʻomaka i ka therapy ʻo Lorista me 25 mg i kēlā me kēia lā i kahi hoʻokahi.

ʻO nā maʻi ʻōpiopio, nā mea maʻi me ka hana renal impaired (me nā mea maʻi i ka hemodialysis) pono pono e hoʻoponopono hou i ka hopena mua o ka lāʻau.

I nā maʻi me ka pīhoihoi hana ʻōmaʻomaʻo, e pono ke kuhikuhi i ka lāʻau ma kahi haʻahaʻa.

Nā Papa 12,5 mg, 25 mg, 50 mg a me 100 mg.

Lorista N (hoʻohui pū ʻia ka 12.5 mg o hydrochlorothiazide).

Lorista ND (hoʻohui ʻia he 25 mg o ka hydrochlorothiazide).

ʻO nā makana heva ma + Chartart.

ʻOsi ka ʻaiā losartan + hydrochlorothiazide + nā mea hanohano (Lorista N a me ND).

Lorista - Angiotensin selectile 2 mau receptor antagonist ʻano AT1 i ʻole nā kaine-protina.

He hōʻemi ia i OPSS, kaomi i ke kaomi pulmonary, e hōʻemi ana ma hope o ke kaumaha, he hopena diuretic.

Kūleʻa ʻia me ka hoʻomohala ʻana o ka hypertrophy myocardial, hoʻonui i ka hoʻolahalaha ʻana i nā maʻi me nā maʻi ʻoi ʻole ka maʻi.

Loaʻa ia ʻo Lorista hoʻokahi manawa i ka lā e alakaʻi i kahi emi nui o ka systolic a me ka diastolic blood pressure.I loko o ka lā, ke kaohi nei ka losartan i ke kahe o ke koko, aʻo ka hopena antihypertensive e pili i ka ʻenikani circadian kūlohelohe. ʻO ka emi o ke kahe o ke koko i ka hopena o ka hopena o ka lāʻau lapaʻau ma kahi o 70-80% o ka hopena i ka hopena o ka lāʻau, 5-6 mau hola ma hope o ke lawelawe ʻana. ʻAʻole mālama ʻia ka maʻi kahalike, a ʻaʻohe o ka losartan i ka hopena koʻikoʻi ma o ka puʻuwai puʻuwai.

Maikaʻi ʻo Losartan i nā kāne a me nā wahine, ʻoiai ʻo ia i nā ʻelemakule (≥ 65 mau makahiki) a me nā mea maʻi ʻōpio (≤ 65 mau makahiki).

Ke hopena nei ka hopena antihypertensive ma hope o nā lā 3-4, akā hiki paha i nā wiki 3-4 e hoʻokō ai i ka hopena therapeutic maikaʻi loa.

ʻO nā pharmacokinetics o losartan a me hydrochlorothiazide me ka hoʻohana like ʻole i ʻokoʻa ʻole i ko lākou hoʻohana ʻokoʻa.

Ma hope o ka lawelawe waha, ʻo ka hoʻokomo ʻana o ka hydrochlorothiazide, ʻo 60-80%. ʻAʻole i hoʻohālikelike ʻia ka Hydrochlorothiazide a ua lawe wikiwiki ʻia e nā keiki.

haehae maʻi
hōʻemi iki i ka hopena o ka maʻi ma nā maʻi me ka hypertension arterial a waiho aku i ka hypertrophy ventricular,
ka huhū o ka puʻuwai kūpilikiʻi (ma ke ʻano he hui hoʻohui, me ka intolerance a i ʻole ka launa ʻana o ka maʻi me ka ACE inhibitors),
ka pale ʻana i ka hana kidney ma nā mea maʻi me ka diabetes mellitus type 2 me ka proteinuria e hōʻemi i ka proteinuria, e hōʻemi i ka holomua o ka hōʻeha o ka pūpū, e hōʻemi ana i ka hoʻoulu ʻana i ka ʻōpū (pale i ka pono o ka dialysis, ʻānō e hoʻonui ka serum creatinine) a i ka make.

haehae
hyperkalemia
huehue
lactose intolerance,
galactosemia aiʻole glucose / galactose malabsorption syndrome,
hapai
lactation
a hiki i nā makahiki 18 a (ʻaʻole i hoʻokumu ʻia ka pono a me ka palekana i nā keiki),
hypersensitivity a losartan a me / a me nā mea ʻē aʻe o ka lāʻau lapaʻau.

Hoʻokomo i ka hiki ke lawe i nā kaʻa a kāohi i nā mīkini

ʻAʻohe ʻikepili e pili ana i ka hopena o Lorista i ka hiki ke hoʻokau i nā kaʻa a i ʻole nā ʻano ʻenehana ʻē aʻe.

āhāhuʻe
ʻaiaiaia
lie kanikela
mea momona
ʻōpala
hopohopo
hiamoe a hiamoe ʻole
hiamoe
nā hoʻomanaʻo hoʻomanaʻo
peripheral neuropathy,
aloha
hale hoʻokaumaha
migraine
hāpau
manaʻo ʻino
orthostatic hypotension (dosis-hilinaʻi),
puʻuwai puʻuwai
tachycardia
brieociaia
nā arrhythmias
ʻinalelo angina pectoris
ihu ʻōpala
huhū
ʻOluomini
ka ʻōpū ʻana o ka muha,
paila, mamaila,
nā ninia
ʻeha ka ʻōpū
anorexia
ka malo maloʻo
nūloʻā
he ʻano hūnā
constipation
koi aku i ka urinate
huakaʻi renal function,
hoʻemi i ka libido
huakai
nahoa
ʻeha ma hope, ʻāʻī, nā wāwae,
kani ana i na pepeiao
nā kuhi hewa
ʻike maka
konohiki
anemia
ʻO ka poni Shenlein-Genoch
maloʻo maloʻo
hoʻonui hoʻonui ʻia
alopecia
kohola
urticaria
ʻili ka ʻili
angioedema (me ka komo ʻana o ka larynx a me ka alelo, e hoʻopiʻi ai i nā ʻōhua o ke ala a me / a me ka haki ʻana o ka maka, nā lehelehe, pharynx).

ʻAʻole ke ʻano o nā hōʻuluʻulu maʻi o ka maʻi me ka hydrochlorothiazide, digoxin, kūlohelohe anticoagulants, cimetidine, phenobarbital, ketoconazole a me ka erythromycin i nānā ʻia.

ʻO ka hoʻohana like ʻana o nā lāʻau anti-inflammatory non-steroidal, me nā mea koho selective COX-2, hiki ke hōʻemi i ka hopena o nā diuretics a me nā lāʻau antihypertensive.

Nā hōʻike o ka lāʻau Lorista

Hoʻololi nā kumu hoʻohālike o ka waiwai ikaika: