ʻO Gluconorm - kahi lāʻau lapaʻau no ka maʻi maʻi type 2

Loaʻa ka lāʻau lapaʻau ma ke ʻano o nā papa ākea keʻokeʻo, convex ma nā ʻaoʻao ʻelua. Hoʻopaʻa ka lāʻau lapaʻau i nā pūʻulu blister o 10 mau ʻāpana i kēlā me kēia. Aia i ka pahu pahu nā 4 kōla. Aia nō hoʻi nā puana me 2 blisters o 20 papa.

Aia i ka papa ʻaina Gluconorm:

• hui metropin kahaha - 400 mg,
• glibenclamide - 2,5 mg.

No ka hoʻonui i ka bioavailability, ka pūhui me nā māhele hoʻohui: gelatin, glycerol, diethyl phthalate, sodium croscarmellose, huʻai palaoa, kānalua kānana, magnesium stearate, colloidal silicon dioxide, microcrystalline cellulose.

Ka hana lāʻau lapaʻau

ʻO ia ka hui pū ʻana o nā lāʻau hypoglycemic mai nā hepoki olakino heterogeneous: metformin a me glibenclamide. ʻO ka hope kēia e pili ana i nā derivatives o sulfonylurea o ka lua o ka hanauna. Hoʻonui i ka pae o ka hōʻeuʻeu o ka glucose o nā cell beta pancreatic, e hoʻonui ana i ka mea huna o ka insulin i ka papa ʻelua. Hoʻokomo i ka naʻau hoʻoliʻi a me ka paepae o kona hoʻopaʻa ʻana i nā ʻāpana e hoʻopaʻa ai. Hoʻonui ka Glibenclamide i ka hoʻopili ʻana o ke kō e ka selu a me nā ʻōpū o nā pupu, a i ka manawa like i ka pale ʻana i ka wāwahi ʻana i nā momona i ka pae lipase.

Hele mai ʻo Metformin mai ka pūʻulu o nā biguanides. Hoʻolālā e hoʻonui i ka naʻau a hoʻonui i ka hoʻonui ʻana i ka glucose e nā kino peripheral. ʻO ka mea ola e hoʻemi i ka nui o nā lipoproteins haʻahaʻa haʻahaʻa a me ka triglycerides, i loaʻa ka hopena maikaʻi i ka lipid profile ma ke koko. Kāohi i ka hoʻokumu ʻana o nā palaki kolesterol me ka hoʻohana ʻole ʻana i kahi hopena hypoglycemic.

ʻO Glibenclamide

Ma hope o ka lawelawe waha, ka adsorption o glibenclamide i loko o kahi ʻōpū liʻiliʻi he 50-85%. Ua hiki i ka waiwai ke koʻo i loko o ke koko ma hope o nā hola 1,5-2. Hoʻohālikelike ia i nā protein plasma e 95%.

ʻO Glibenclamide kahi o ka loli piha loa i loko o ke ake me ka hana o ʻelua mau metabolites ʻaʻole i hana. Hoʻopalaha kaʻawale ma o nā ʻōpū a me ka gastrointestinal tract. Hoʻomoe ka hapalua-ola mai 3 a 16 mau hola.

Ke komo nei ia i ka gastrointestinal tract, hoʻokomo ʻia ke kau piha. Loaʻa ka bioavailability 50-60%. ʻO ka wehe ʻana o nā mea e hoʻokaʻawale me kahi pāʻina hoʻokahi. 30% o ka metformin e hoʻopuka ʻia i loko o nā huapo. Holo koke ʻia ke koena ma waena o nā kiko liʻiliʻi me ka ʻole e hoʻopili i nā protein plasma.

Loaʻa ka hapalua hapalua o nā hola 9-12. Kokoke ʻaʻole i komo i loko o ka metabolism. Hoʻoholo ʻia ka metformin mai ke kino e nā keiki.

Hoʻohana ʻia ka Gluconorm e nā mea maʻi me nā maʻi maʻi 2:

• me kaʻai haʻahaʻa a me ka hoʻomaʻamaʻa,
• me ka nele o ka metformin therapy ma mua i nā poʻe me ka pae o ke kō.

Noi ʻia no ke hoʻohana ʻana e nā kānaka ma luna o 18 mau makahiki.

Nā Hoʻohui

Hoʻololi ʻia ka Gluconorm no ka hoʻohana ʻana:

• ʻO nā maʻi maʻi maʻi diabetes
• wahine i ka wā hāpai a me ka lactation,
• me ka pākaukau hoʻokahi o ka miconazole,
• i ke alo o kāna hana nui ʻana i ka pilikia.
• poʻe me ka haʻahaʻa haʻahaʻa
• nā mea maʻi me ka maʻi porphyrin i ʻeha ʻia e nā maʻi maʻi,
• i ka wā postoperative i ka wā o ke kaʻina hana e hoʻopau ai i ka puhi ʻana o kahi wahi nui.
• me ka pēpē a me ka hana pāpaʻi ʻana, a me nā kūlana e alakaʻi ana iā lākou (ka ʻole o ka pale ʻana o ka paʻakai-paʻakai, lōʻihi ka maloʻo, ka myocardial infarction a me ka pulmonary failō)
• me ka mea e make ai ke kino me ka mea huna,
• ʻelua mau lā ma mua a ma hope o ka radiography e hoʻohana ana i kahi kūlike, ʻo ia hoʻi ka iodine,
• me ka hopena maʻi lactic acid,
• e'āpono ia i ka pāʻai haʻahaʻa-mea, kahi mea e ʻai ai kekahi mea i emi iho ma mua o 1000 kcal / lā,
• i ka heleʻana o kahi hopena alakine i metformin a me nā mea kōkua.

Hāʻawi ʻia ka mālama ʻia ʻana i ka hihia o ke kuni, hana lima a me ka hoʻonaninani o nā kelepa adrenal, i ka hihia o ka hana o ka pituitary o mua a me nā kūlohelohe thyroid.

Nā ʻōkuhi no ka hoʻohana (dosage)

Kuhi ʻia ka Gluconorm no ka hoʻoponopono waha. Koho ʻia ka helu o ka lāʻau i kēlā me kēia kanaka e ka ʻaha kauka komo. ʻO ke kumu no ke kuʻina o ke ʻano maʻamau i kēlā me kēia lā.

I ka hoʻomakaʻana o ka lāʻau lapaʻau, e kuhikuhi ana ka mea maʻi 1 papa i ka lā. Ma hope o nā lā 7-14, e hoʻoponopono ʻia ka hopena o ka lāʻau e like me ka hopena o ka huli ʻana i ka pae o ka glucose i ke koko. ʻAʻole pono nā kauā kiʻekiʻe loa i ka 5 papa i kēlā me kēia lā.

Ma ka hihia o ka hoʻololi ʻana o ka hui mua o ka metformin a me ka glibenclamide, ua kuhikuhi ʻia nā papa he 1-2 o Gluconorm i ka mea maʻi, e pili ana i ka maʻi o mua o kēlā

Nā hopena hopena

Mai ka ʻaoʻao o ka mea laʻa kalaiwa, ma nā hihia maʻamau, ulu ka hypoglycemia.

Me nā hopena ʻaoʻao o ka ʻeha gastrointestinal a me nā leʻaleʻa, hiki paha i ka mea maʻi ke hele i ka nausea, ka luaʻi, ka ʻeha ma ka wahi o ka epigastric, ka nele o ka momona, ka ʻono "ʻono" i loko o ka waha. I nā hihia pinepine, hōʻike ʻia ka jaundice, hoʻonui ʻia ka hana o nā enzyme o ka ate, ua ulu ka maʻi hepatitis.

Leukopenia, thrombocytopenia, erythrocytopenia, agranulocytosis, hemolytic a megaloblastic anemia, pancytopenia ulu inā ʻike ʻia nā hopena mai ke ʻano hematopoietic.

Hiki i ka ʻōnaehana o ke kikowaena ke kū me ka hōʻeha, ka ʻeha, ka nāwaliwali a me ka māhuahua. I nā pilikia pinepine, paresis, ʻike ʻia ka maʻi paleka.

Hōʻike ʻia ka maʻi āpau i ke ʻano o nā hopena dermatological:

• urticaria
• erythema
• kaʻiliʻili
• fiva
• aolaila
• proteinuria.

Mai ka ʻaoʻao o ka metabolism, hiki i ka lactic acidosis.

Nā mea hou: ka hopena kūlohelohe o ka hōʻemi o ka waiʻona ma hope o ka inu ʻana, i hōʻike ʻia e ka hoʻopiʻi ʻana o ka kaʻe a me ka hanu (disulfiram-like ka hopena: pihoʻi, hoʻāhu ka wela o ka maka a me ke kino o luna, tachycardia, dizziness, headache).

Ke keu

Me kahi overdose o ka lāʻau lapaʻau, kūlohelohe kēia mau hōʻailona e like me:

• pololi
• hoʻonui nui loa
• palpela puʻuwai,
• haʻalulu (haʻalulu) o nā wāwae,
• hopohopo a me ke kaumaha
• poʻomanaʻo
• ʻōpala
• huhū
• photosensitivity, ʻike maka a me ka hana waha.

Inā ʻike ka mea maʻi, pono ke kō. I kahi kūlana ʻole, pono ʻole e 1-2 ml o glucagon a me ka dextrose intravenous. Ke hoʻihoʻi nei i kahi ʻike maopopo, pono nā mea maʻi e ʻai i ka meaʻai e loaʻa ana nā kaola kino.

Ma muli o ka heleʻana o ka metformin i ka "Gluconorm", hoʻomohala paha ka mea maʻi i ka acidosis lactic. Ke koi nei kēia ʻano maʻi mālama maʻi olakino a me ka loaʻa ʻana o nā maʻi lapaʻau ma o hemodialysis.

Hoʻohui nūhou

Hiki i kahi hoʻonui hoʻonui hoʻonui:

• allopurolol,
• nā huaʻehā hypoglycemic ʻē aʻe (pūʻulu biguanide, insulin, acarbose),
• kalaiula
• monoamine oxidase inhibitors
• antikoagulants
• liuliuliu,
• steroids anabolic
• hoʻoluʻu sulfonamides,
• huoli
• paikiki
• fenfluramine,
• laiula
• Pyridoxine
• halihaili
• palekezila
• ʻAnee ACE (enalapril, captopril),
• histamine H2 blocker blockers (cimetidine),
• antifungal (miconazole, fluconazole) a me nā lāʻau anti-TB,
• Kelekaeka.

Glucocorticosteroids, barbiturates, antiepileptics (phenytoin), acetazolamide, thiazides, chlorthalidone, furosemide, triamterene, asparaginase, baclofen, danazol, diazoxide, isoniazid, Morphine, ritodrine, salbutamol, terbutaline, glucagon, rifampicin, thyroid hormones, likiuma paʻakai hiki o hoʻonāwaliwali i ka hopena o ka lāʻau lapaʻau.

Nā mea hoʻohālikelike, hoʻōla ʻo nikotinic, estrogens a me chlorpromazine i ka hopena o ka lāʻau.

I ka nānā ʻana o ka hoʻohaʻahaʻa o ka dissociation a me ka nui o ka reabsorption o glibenclamide, ammonium chloride, calcium chloride, ascorbic acid (ma kahi kiʻekiʻe nui) hoʻonui i ka hana a ka lāʻau lapaʻau.

"Hoʻonui ka" Furosemide "i ka nui o ka piʻiʻana o ka metformin e 22%. Hoʻonui ka "Nifedipine" i ka hoʻopili ʻana, akā e hoʻonui ka lōʻihi o ke koʻo i ka hoʻopā o nā mea ikaika.

Amyloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren a vancomycin mai ka cationic row no nā ʻōnaehana transport tubular, me ka hoʻohana lōʻihi me ka hoʻonui ʻana i ka manaʻo o ka metformin e 60%.

Nā ʻōlelo kikoʻī

Pono ka hoʻoneʻe ʻana i nā lāʻau lapaʻau a hoʻololi i ka therapy insulin me ka hihia ʻoi loa ka hopena o ka hōʻeha ʻana ma hope o ka hana ʻana, ka hōʻeha ʻana, ke puhi ʻana i kahi kīʻaha nui, me ia ke ʻano o ka maʻi o ke kino, ka hoʻopiʻi ʻia e ke kuni.

I ka wā hana no ka mālama ʻana, e koi ʻia ka nānā ʻana i ka glucose.

Me ka wikiwiki o ka wikiwiki, a me ka inu ʻana i ka waiʻona, e hoʻohaʻahaʻa ʻia ka nui o ka hāʻule o ka nui o ka pika o ke koko. Wahi a ka noiʻi, i ka wā mālama, ʻaʻole i ʻae ʻia ka waiʻona. Me ka hoʻoulu ʻana o ke kino a me ke kaumaha, ua hoʻoponopono ʻia ka nui o ka lāʻau, loli ka meaʻai.

ʻElua mau lā ma mua o nā hana ʻoki ʻana a i ʻole hoʻokele intravenous o nā iodine e loaʻa ai nā mea kūlike i koi ʻia no ka radiography, ua hōʻa ʻia ka lāʻau. E hoʻomau ma hope o 48 mau hola ma hope o nā haʻawina.

I ka wā o ka mālama ʻana, pono ia e pale i nā hana like ʻole e koi ai i ka hoʻoulu ʻana a me ka piʻi o nā neʻe kaʻa. ʻAʻole kuhikuhi ʻia ke kaʻa.

ʻŌpū a me ka lactation

Lā ʻia ka lāʻau lapaʻau no ka hoʻohana ʻana i ka wā hāpai. No ka manawa hoʻolālā a hoʻomanawanui, paʻa. Ua kāpili ʻo Gluconorm i ka insulin therapy.

ʻAʻole pāpā ʻia nā wahine i ka wā lactation e lawe i ka lāʻau lapaʻau ma muli o ka komo ʻana o ka metformin i loko o ka waiū umauma. Pono nā makuahine e huli i ka inika insulin. Inā ʻaʻole hiki i kēia hana, keʻakeʻa i ka umauma.

Hoʻohālikelike me nā kikowaena

KINA U! Hoʻoleʻo loa ia e hoʻokō i kahi kūʻokoʻa kūʻokoʻa o Gluconorm me nā lāʻau lapaʻau ʻē aʻe me ke kūkā ʻana i kahi kauka.

1. ʻO Glibomet. Loi nā mea kanu like: metformin a me glibenclamide. Ke lawe nei i ka lāʻau lapaʻau, hoʻonui ʻia nā mea huna o nā hormones e nā hua o ka pancreas a me ka hōʻemi ʻana o nā io i ka hana a ka insulin e hoʻonui.

Akā ʻaʻole e like me Gluconorm, ʻike ʻia no ka hoʻohana ʻana:

• Hoʻohana ʻia ka "Glibomet" i ka wā e kūpaʻa ai ke kino i nā derivatives sulfonylurea ma muli o ka hoʻohana lōʻihi,
• me kahi ʻano like ʻole o ka maʻi diabetes.

ʻO ka manawa mālama a me ka helu o kēlā me kēia lā ʻo "Glibomet" ʻaʻole i hilinaʻi wale ʻia i ka kukuna o ka glucose i loko o ke koko, akā hiki nō hoʻi i ke ʻano o ka pauna o ka hōʻoliʻeu o ka mea maʻi.

Hōʻike ka ʻokoʻa ʻole i kona iho i kekahi mau hopena ʻaoʻao:

• he haki ʻana i ka helu sela keokeo,
• kūloko i ke ʻano kūloko i ke ʻano o ka ʻili o ke kino (itching, redness),
• Koho ʻia ka ʻona maikaʻi a me ka mālama mau ʻana i ka mea maʻi.

ʻOi aku ke kumukūʻai he 90-100 rubles kiʻekiʻe.

Metglib. ʻO ka hana maʻalahi like nā mea like. Aia ka ʻokoʻa i ka hoʻohuihui o nā mea kuʻina, e hoʻonāukiuki i ka hoʻohemo ʻana o ka glucose i loko o ka ʻōpū liʻiliʻi, a pale pū i ka gluconeogenesis a me ka glycogenolysis i loko o ka ate.

ʻO ka "Metglib" ho'ēmi i ke kaumaha o ke kino o ka mea maʻi ma o ka pale ʻana i ka hoʻokumu ʻana o ka cholesterol a me nā lipoproteins haʻahaʻa haʻahaʻa. Hōʻike ʻia ka lawe ʻana i ka lāʻau lapaʻau me Bozentan no ka hopena o ka loaʻa ʻana o ka maʻi hepatic.

ʻAʻole i haʻahaʻa ke kumukūʻai ma Gluconorm.

Pharmacodynamics a me ka pharmacokinetics

Aia i nā Gluconorm kahi hui pū ʻelua o nā mea hypoglycemic ʻelua e pili ana i nā hui kāmeka lapaʻau ʻē aʻe: metformina glibenclamide.

I ka manawa like, ʻo kahi metformin kahi biguanide hiki ke hoʻohaʻahaʻa i ka pae o ka maʻi glucose i ka hoʻolālā o ka serum koko. ^ E Ha yM. Loaʻa ia i ka hoʻonui ʻana i ka ʻike o nā kino peripheral i ka hana a ka insulin a me ka hoʻonui ʻana i ka hopu kekuhi. Eia nō hoʻi, ʻo ka hoʻopili ʻana o nā kalaka mai ka hoʻowalewale ʻana e hōʻemi a pale ʻia gluconeogenesis i ka huakai. ʻO ka hopena pono o ka lāʻau lapaʻau, ke kuhikuhi nei i ke kūlana lipid o ke koko, i hoʻomaopopo ʻia, nā hōʻailona o ka laulā kolamu atriglycerides. ʻAʻole e ulu nā hanana hypoglycemic.

ʻO Glibenclamide kahi makahiki 2 o ka kōmākūkā sulfonylurea. Hōʻike kēia ʻāpana i ka hoʻoulu ʻia o ka ʻenehana huna no ka hoʻoneʻe ʻana i ka hopena hoʻonāukiuki o ka glucose β-cells i loko o ka pancreas, ka ʻike ʻana i ka insulin, a me ke ʻano o kona pilina me nā cell target. Hoʻopili ia, hoʻonui i ka hoʻokuʻu ʻana i ka insulin, i ka hopena o ka insulin i ka hoʻopili ʻana o ka glucose e nā kiko uaua a ua hoʻoikaika ʻia ka puʻupaʻa, a me ka lipolysis i nā pā adipose e pale ʻia. Hōʻike ʻia ka hana o kēia ʻano i ka lā 2 o ka ʻaina insulin

Hoʻomaʻamaʻa maikaʻi ka lāʻau mai ka papa hana ʻole. Loaʻa ka ʻike kiʻekiʻe loa i loko o 1,5 mau hola. Ke hopena hoʻokūkū lehulehu nā metabolites. ^ E Ha yM. Hoʻokuʻu ʻia ka lāʻau mai ke kino me ke kōkua o nā keiki a me nā loko.

Nā hōʻailona no ka hoʻohana ʻana

Hoʻonohonoho ʻia ka noi a Gluconorm no diabetes type 2 no nā mea maʻi me:

• pono kaʻai ʻana i ka meaʻai kūpono, ka hoʻoikaika kino a me ka mālama mua ma ka glibenclamide a i ka metformin,
• ka pono e hoʻololi i ka lāʻau ma mua me kēia lāʻau lapaʻau no nā poʻe maʻi e hoʻomau a mālama pono ʻia ka heluhelu ʻana o ka hoʻokahe koko.

E hoʻokuʻu i ke ʻano a me ka ʻano

Ka puka ʻana - nā papa ʻoniʻoni kiʻi: ka pōpō, convex ma nā ʻaoʻao ʻelua, aneane keʻokeʻo a ʻele paha paha, i ke kuʻi ʻana - mai ke keʻokeʻo a keʻokeʻo-hina i loko o ka waihoʻoluʻu (10 mau ʻōpala i kahi blister, 4 mau kihihi i loko o ka pūlima kāleka, 20 pcs i kahi kue , 2 mau puka i kahi kāwele kāleka).

Nā mea e pili ana i ka 1 papa:

• hui metropin kahaha - 400 mg,
• glibenclamide - 2,5 mg.

Nā kumuhana hou: diethyl phthalate, sodium croscarmellose, glycerol, gelatin, starch palaoa, cellulosefate, huikala ʻia, colloidal siliconide, sodium carboxymethyl starch, microcrystalline cellulose, magnesium stearate.

Nā hopena hopena

Ke lawe nei i Gluconorm, hiki i nā hopena hopena ke ulu i ka hopena o ka metabolism, ke akepaʻa a me ka hana gastrointestinal, hematopoiesis a me ka wahī. Hiki kēia me kēia: hypoglycemia, lactic acidosis, nausea, ka luaʻi, ka ʻōpū o ka ʻōpū, ka nalowale. mea momona, leukopenia, thrombocytopenia, erythrocytopenia, hōʻeha, kuʻewanāwaliwali, nā mānoanoa kiʻekiʻe a pēlā aku.

ʻO Gluconorm, nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana (Ke ʻano a me ke ʻano)

Kuhi ʻia kēia lāʻau lāʻau no ka hoʻokele waha i ka manawa like me nā meaʻai. Ma kēia hihia, ua kau ʻia ka nui o ka lāʻau lapaʻau e ke kauka, i ka nānā ʻana i nā ʻano kūʻokoʻa o kēlā me kēia maʻi e pili ana i ka pae o ka glucose i ke koko.

E like me ke kānāwai, hoʻomaka ka lāʻau lapaʻau i kēlā me kēia lā - 1 papa. I kēlā me kēia mau pule he 2, e hoʻoponopono ʻia ke ʻano e like me ka pae o ka glucose i ke koko. Ke kū hou nei ke ʻano o ka mālama ʻana ma mua me ka metformin a me ka glybeklamide, ua kau ʻia nā papa lāʻau 1-2 i nā maʻi. I kēia hihia, ʻaʻole hiki ke ʻoi aku ka nui o nā lā i kēlā me kēia papaʻa.

Nā hōʻailona no ka koho ʻana o ka gluconorm

I nā maʻi he nui me ka maʻi mellitus, ʻaʻole hiki i nā lāʻau lapaʻau ke mālama pono i ka glucose, no laila e hele pinepine nā kauka i ka mālama hoʻohui. Hōʻikeʻike no kona koho ʻana i ka hemoglobin glycated ma luna o 6.5-7%.ʻO ka hoʻolālā maikaʻi loa e hoʻohui i nā metformin me nā derivatives sulfonylurea (PSM), nā gliptins a me nā mimetin mimetin. Hoʻopili kēia mau hui āpau i ka pale ʻana i ka insulin a me ka hoʻoneʻe ʻana i nā inikini insulin, no laila hāʻawi lākou i ka hopena maikaʻi loa.

ʻO ka hui pūʻana o ka metformin + sulfonylurea ka mea maʻamau. ʻAʻole hiki i nā mea like ke launa me kekahi, ʻaʻole e hōʻemi i ka pono. ʻO Glibenclamide ka ikaika loa a aʻo i nā PSM āpau. He kumu haʻahaʻa ko ia a kūʻai ʻia aku i kēlā me kēia lāʻau kūʻai, no laila, i hui pū me ka metformin, ua kuhikuhi pinepine ʻia ka glibenclamide ma mua o nā lāʻau lapaʻau. No ka maʻalahi o ka hoʻohana ʻana, ua kūkulu ʻia nā papa ʻelua i wae ʻia me kēia mau mea hoʻoikaika ʻelua - Gluconorm a me nā mea hoʻohālike.

Wahi a nā ʻōlelo kuhikuhi, Hoʻohana wale ʻia ʻo Gluconorm no ka maʻi maʻamau ʻo 2, inā he hoʻoponopono kūpono ʻana i nā meaʻai, ʻakena a me nā metformin, ʻaʻole e hāʻawi i ka hāʻule o ka glucose i nā waiwai. ʻAʻole pono ka hopena o ka metformin i liʻiliʻi ʻia (2000 mg) a i ʻole e ʻae ʻia e ka maʻi maʻi. No laila, hiki i nā gluconorm ke lawe i nā maʻi e inu ʻokoʻa i ka glibenclamide a me ka metformin i hoʻokaʻawale.

Ua ʻike ʻia ka noiʻi: ka hapa liʻiliʻi o ka papa maʻi e lawe nei i kēlā me kēia lā, ʻoi aku ka nui o ka hoʻokō ʻana i nā kauoha a pau a nā kauka, ʻo ia ka mea o ke kiʻekiʻe o ka hoʻomaʻamaʻa ʻana. ʻO ia ke lawe ʻana iā Gluconorm ma mua o ʻelua papa he papa liʻiliʻi i ka uku ʻana no ka maʻi diabetes.

Eia kekahi, ʻelua o ka hoʻonui ʻana i loko o ka nui o ka pākaukau o nā papa kōniha o ka honi, ʻaʻole e hāʻawi i ka like me ka hoʻēmi ʻana i ke kō. ʻO ia, e hana pono nā lāʻau lapaʻau ʻelua i loko o kahi liʻiliʻi liʻiliʻi e hāʻawi i nā hopena ʻokoʻa ma mua o hoʻokahi lāʻau i ka nui loa o ka nui o ka nui.

ʻO ka hiʻohiʻona a me ka hopena o ka lāʻau lapaʻau

Ua hooulu ʻia ʻo Gluconorm e ka hui ʻo Lūkini ʻo Pharmstandard i ka hana pū ʻana me a me Biopharm India. Loaʻa ka lāʻau lapaʻau i 2 mau hiʻohiʻona:

1. Ua hana ʻia nā papa Gluconorm i India, i hoʻopili ʻia ma Rusia. ʻO ka lāʻau lapaʻau ka maʻi kūmole maʻamau o 2.5-400, ʻo ia hoʻi, ʻo kēlā me kēia papa o ka metformin ka 400 mg, glibenclamide 2.5 mg.
2. Ua hoʻohālikelike ʻia nā papa Gluconorm Plus ma Rūsia mai kahi lāʻau lapaʻau i kūʻai ʻia ma India a me China. Loaʻa iā lākou i 2 mau kaukaʻi: 2.5-500 no nā maʻi hānai me ka pale kiʻekiʻe o ka insulin a me 5-500 no nā mea maʻi me ka kaupaona ʻole, akā me ka emi ʻana o ka insulin.

Mahalo i nā koho helu ʻaiʻokoʻa, hiki iā ʻoe ke koho i ka pae kūpono no kēlā me kēia mea maʻi me ka maʻi diabetes type 2.

E noʻonoʻo pono i kā mākou ʻoihana pehea e hana ai nā mea like o ka lāʻau Gluconorm. ʻO ka Metformin e hōʻemi ana i ka glycemia postprandial a me ka wikiwiki ka nui ma muli o ka emi ʻana o ka pale o ka insulin. Hoʻopau hele i ka maʻi o nā kīʻaha ma muli o ka hoʻonui ʻana o ka naʻau i ka insulin. Hoʻololi hoʻi ka Metformin i ka hoʻokumu ʻana o ka glucose i loko o ke kino mai nā mea waiwai ʻole-kalaiwa, e hoʻolei ana i kona komo ʻana i ke koko mai ka hana ʻana o ka huina.

No nā maʻi maʻi, ʻo nā waiwai hou o ka metformin ʻaʻole i pili me ka hōʻemi ʻana i ka glycemia he mea nui loa hoʻi. Mālama i ka lāʻau lapaʻau i ka hoʻomohala ʻana o ka angiopathy ma o ka hoʻoponopono ʻana i nā lipid koko, hoʻomaikaʻi i ka pono o ka ʻiʻo. Wahi a kekahi mau hōʻike, hiki i ka metformin ke pale aku i ke ʻano o nā neoplasms. Wahi a nā mea maʻi, e hoʻemi ana ia i ka momona, kōkua i ka mālama ʻana i ke kaumaha maʻamau, hoʻoikaika i ka hoʻolilo ʻana, a hoʻonui i ka pono o ka meaʻai.

ʻO Glibenclamide ʻo ka hanauna PSM 2. Hoʻololi pololei ia i nā pūpū beta pancreatic: hoʻohaʻahaʻa ia i ka paepae o ko lākou nānā i nā pae glucose koko, no laila e hoʻonui ai i ka hana o ka insulin. Hoʻonui ka Glibenclamide i ka glycogenogenesis - ke kaʻina o ka mālama ʻana i ka glucose i nā ʻiʻo a me ka puʻuwai. ʻAʻole i like me ka metformin, hiki i kēia lāʻau lapaʻau ke hōʻeha i ka hypoglycemia, ʻoi aku ka paʻakikī ma mua o nā poʻomanaʻo o ka hui PSM - glimepiride a me glyclazide. Ua manaʻo ʻia ʻo Glibenclamide ka mea ikaika loa, akā, ʻo ia hoʻi ka mea kino i ka PSM. ʻAʻole ia i hāʻawi ʻia no nā maʻi maʻi me ka kiʻekiʻe o ka maʻi hypoglycemia.

Pehea e lawe ai i ka lāʻau lapaʻau Gluconorm

ʻO ka hopena maʻamau o ka metformin ka hoʻoweliweli ʻana, glibenclamide - hypoglycemia. Hiki iā ʻoe ke hōʻemi i ka hopena o nā hopena maikaʻi ʻole o ka mālama ʻana me ka gluconorm, ka lawe ʻana i nā paila i ka manawa like a me ka hoʻonui iki ʻana i ka ʻōpū, hoʻomaka me ka liʻiliʻi.

Nā ʻāpana o ka lāʻau Gluconorm e like me nā ʻōlelo aʻoaʻo:

Me ka pale kūʻē o ka insulin, ka mea e ʻano o ka poʻe lese me ka maʻi diabetes, hiki ke kuhikuhi ʻia i ka metformin hou. ʻO ka maʻamau pinepine lākou i inu ai ma mua o ka hele ʻana o ka moena. Manaʻo ʻia o ka momona o kēlā me kēia lā e like me 2000 mg, ka nui - 3000 mg. ʻO ka hoʻonui aʻe i ka dosage he pilikia me ka lactic acidosis.

Me ka hapa ole o nā karoli i ka meaʻai, Gluconorm ka mea kumu o ka hypoglycemia. No ka paleʻana, ua inu nā papa me nā papa nui. Pono i nā huahana me nā kalapika, hapanui. ʻAʻole hiki iā ʻoe ke ʻae i nā lōlū lōʻihi ma waena o nā pāʻina, no laila e ʻōlelo ʻia nā mea maʻi i nā kīleʻi hou. Hōʻike nā loiloi o ka maʻi maʻi me ka hoʻomaʻamaʻa kino pilikino, hiki i ke kōpaʻa ke hāʻule i loko o kahi mau minuke. I kēia manawa, pono ʻoe e makaʻala nui i kou olakino.

Nā Palepili a me nā mea wae

ʻO ka analogue piha, a me ka metformin a me glibenclamide hoʻokaʻawale, hiki ke inu maluhia i loko o nā ʻano like ʻole me ka Gluconorm. Inā ʻoe e hoʻolālā e hoʻololi i ka mālama ʻana me kahi derivative sulfonylurea, e koho hou ʻia ka makehe. ^ E Ha yM. Manaʻo nā kauka i ke hoʻololi ʻana mai Gluconorm i Amaryl a i Glimecomb no nā maʻi maʻi me nā maʻi kalaka o ka 2, ʻike pinepine ʻia i ka hypoglycemia.

Wahi a nā loiloi, e pili pono ana ka hopena o Gluconorm a me nā mea hoʻohālikelike, akā makemake mau nā maʻi maʻi i ka German Glybomet, e noʻonoʻo ana i ka lāʻau lapaʻau kiʻekiʻe loa.

ʻO nā kānāwai mālama a me ke kumukūʻai

Kūpono ka Gluconorm no 3 mau makahiki mai ka lā o ka hana. Hoʻonohonoho ʻia ka Gluconorm Plus e kūʻai aku i nā makahiki hou aʻe ma mua o 2 mau makahiki. ʻAʻole i ke aʻo ka mea pono i nā kūlana e waiho ai, ua lawa ia e nānā i kahi kaohi wela o ka nui ma mua o 25 kiʻekiʻe.

Hiki i nā maʻi kanalike Lūkini ke loaʻa nā lāʻau lapaʻau e like me kahi papa kuhikuhi manuahi i hoʻākāka ʻia e kahi mea hoʻohana maʻamau a i ʻole endocrinologist. E kūʻai lilo aku ke kumukūʻai kūʻokoʻa: ʻo ke kumukūʻai o kahi ʻāpana o nā papa he 40 o Gluconorm ma kahi o 230 mau rubles, e uku ana ʻo Gluconorm Plus mai 155 i 215 rubles. no 30 papa. No ka hoʻohālikelike, ʻo ke kumukūʻai o ka Glibomet mua e pili ana i ka 320 rubles.

E kū e aʻo! Manaʻo paha ʻoe i ka hoʻokele o ke ola i nā pōpoki a me ka insulin ke ala wale nō e mālama ai i ke kō i lalo o ka mālama ʻana? ʻAʻoleʻoiaʻiʻo! Hiki iā ʻoe ke hōʻoia i kēia me ʻoe e hoʻomaka e hoʻohana. heluhelu hou aku >>

Nā hiʻohiʻona noi

Pono e kāpae i ka mālama ʻana i ka lāʻau lapaʻau no nā maʻi maʻi ʻeha me ke kuni ʻana, me nā hōʻeha ākea a me nā puʻuwai manuahi. Hōʻeha ka hoʻemi ʻana i ke kōpaeʻai i ka wā o ka pōloli, hoʻonui ʻia ka hoʻohana ʻana o nā NSAID, e hoʻonui ai i ka ethanol. Hoʻopili ʻia ka hoʻoponopono ʻia ʻana i ka wā e hoʻololi nei i ka meaʻai, ka ikaika ʻuhane a me ka hoʻonaninani kino.

ʻO ka ʻōlelo a Gluconorm e wehewehe ʻole ʻia e inu i ka wai ʻona i ka wā o ka maʻi. Hiki i nā peni ke hoʻopili i ka wikiwiki o nā hopena psychomotor a hoʻoemi i ka ʻike. No laila, e makaʻala ʻoe i ka wā e hoʻokele a halihali i nā kaʻa a me nā kaʻa.

Ua papa ʻia ia nā lāʻau lapaʻau i ka wā kamaliʻi, i ka wā hapai, i ka wā hānai, no ka mea ʻo nā mea nui i komo i ka waiū o ka makuahine. Ua hoʻohālikelike ʻia ka lāʻau lapaʻau i nā kānaka me nā mālamalama o nā pēpē a me nā ate. ʻAʻole hoʻolako ʻia ka hoʻohana ʻana i nā papa i ka pākeke me ka hoʻoikaika kino kino nui.

Hoʻopili pū me nā lāʻau ʻē aʻe

Ma mua o ka hoʻomaka ʻana i ke ʻano, pono ʻoe e aʻo e pili ana i ka pili ʻana o Gluconorm i nā lāʻau lapaʻau e ae.

• hoʻonui i ka waiwai hypoglycemic: ACE inhibitors, MAO, NSAIDs, fibrates, allopurinol, anabolic steroids, anti-TB drug, urine acidifying tablets,
• nāwaliwali i ka hopena: hormonal contraceptives, iodine-piha i ka hormone thyroid, barbiturates, adrenostimulants, corticosteroids, nā kikowaena kiʻekiʻe o ka acid nicotinic, glucagon, furosemide, thiazide diuretics, antiepileptic drug,
• hoʻonui i ke kiʻekiʻe o ka metformin: lāʻau lapaʻau cationic, furosemide,
• māhuahua ka laulā furosemide: metformin,
• neeneia ka haʻalele ʻana o ka metformin: nifedipine.

ʻLoe a me ke kākele

Hōʻike ʻia ka Gluconorm no ka hoʻohana ʻana i nā waha. Pono e lawe ʻia nā papa me nā meaʻai.

Kahi ʻia ka wai kūpono no kēlā me kēia maʻi e pākuʻi e pili ana i ka ikepili ma ke pae o ka glucose i loko o ke koko.

ʻO ka pākaukau ma mua he 1 papa 1 mau manawa i ka lā. Inā pono, e hoʻonui i ka ʻai i kēlā me kēia 1-2 mau pule a hiki i ka hopena makemake ʻia.

I ka hihia o Gluconorm ma kahi o ka hui pū ʻana o ʻelua mau lāʻau - metformin a me glibenclamide - hoʻoholo ʻia ke kaukaʻe ʻia ma nā ʻano o mua o kēlā

ʻO ka papa helu ʻokoʻa loa he 5 papa i kēlā me kēia lā.

ʻO ka ʻike nui, ka hoʻonohonohoʻana a me nā ʻano hana

ʻO Gluconorm kahi lāʻau lapaʻau hypoglycemic i kūkulu ʻia ma India. Hoʻopili i nā hopena hoʻohaʻahaʻa hilahila, e kōkua ka lāʻau lapaʻau e hoʻohaʻahaʻa i ka kolene o ke kolamu ma ke koko o ka mea maʻi.

ʻAe ʻia ka wehe ʻana i nā kālā e like me ke koho ʻana o ka loea i hele mai i loko. Hoʻohana ʻia ka lāʻau lapaʻau no 3 mau makahiki mai ka lā i hana ʻia ai.

Pono pono e nānā i nā kūlana mālama o kēia lāʻau lapaʻau. Mālama ʻia ia ma kahi wahi pouli ʻole i ka loaʻa ʻole o nā keiki. ʻO ka mahana mālama mālama pono loa he 20-23 0 C.

Eia kekahi, ʻo Gluconorm me nā blueberries i loko o ke ʻano o kahi kinikini i hoʻoulu ʻia, ʻaʻole ia he laikini, akā ua lawe ʻia me kahi mea inu haʻahaʻa.

I waena o nā mea ʻē aʻe o ka lāʻau, ua hoʻomaopopo ʻia ka sodium carboxymethyl starch, magnesium stearate a me cellacephate. I kekahi mau kikoʻī, talc me nā kōkō palaoa a me nā gelatin i ka hoʻonohonoho ʻana o nā lāʻau.

Hoʻokahi i hoʻokahi o nā papa e pili ana i nā alima o 1-4. I loko o ka pahuhopu hiki ke lilo i 10, 20, 30 mau papa o ka lāʻau lapaʻau. Ke keʻokeʻo a nā papa o ka lāʻau lapaʻau a loaʻa kahi ʻano biconvex a puni. I ka wā hoʻomaha, hiki paha i nā papa ke kiko hina.

ʻAʻole i loaʻa i nā ʻula huapula ʻo Gluconorm ka mea i hōʻike i nā papa i loaʻa i nā papa. Hana ʻia ia mai nā mea kanu kūlohelohe a kūʻai ʻia ma ke ʻano o nā ʻeke peke. Hoʻolālā ʻia ka papa ala o ka hoʻouna ʻana no 3 mau pule.

Pharmacology a me ka pharmacokinetics

He ʻelua kumumanaʻo Gluconorm: Glibenclamide a me Metformin. ʻO nā mea ʻelua e hana i ka hui hui pū ʻana, e hoʻonui ana i ka pono o ka lāʻau lapaʻau.

ʻO Glibenclamide kahi makahiki 2 o ka kōmākūkā sulfonylurea. Ma muli o kāna hana, hōʻeuʻeu ʻia ka hoʻohuihui insulin, a hoʻonui nui ʻia ka insulin i nā cell target.

Hoʻololi ʻo Glibenclamide i ka hoʻokuʻu ʻana i ka insulin a hoʻonui i kona hopena ma ka hoʻopio ʻana o ka glucose i nā puhaluhi, a me nā ʻiole. Ma lalo o ka hana a kahi mea kikowaena, e iho ana ke kaʻina o nā hōʻiliʻi i nā momona.

ʻO ka metformin kahi waiwai nunui. Ma muli o kāna hana, hoʻemi ʻia ka ʻike o ka glucose i ke koko o kahi mea maʻi, aia ka nui o ka loaʻa ʻana o ka glucose i nā kinipōpeka peripheral.

Hoʻonui ka waiwai i ka emiʻana o ka kolamu o ka kolamu ma ke koko. Ma muli o ka hana a Metformin, ua emi ka nui o nā mea make i loko o ka ʻōpū a me nā ʻōpū. Hoʻopili ka mea i ka hana o ka glucose i loko o ka palupalu.

ʻO Glibenclamide lāua ʻo Metformin, kahi ʻāpana o ka lāʻau lapaʻau, he pharmacokinetics ʻokoʻa.

ʻO ka hoʻopili ʻana o ka glibenclamide ma hope o ka hoʻoilo ʻana mai ka ʻōpū a me nā ʻōpū, hiki i ka 84%. Hiki i ke ana o ke kikoo loa o kahi mea i hiki i ke hola a ʻelua paha. Hoʻopili maikaʻi ke ʻano o nā mea me nā protein koko. ʻO ka 95 ka%. ʻO ka hapa haʻahaʻa o nā hapalua he 3 hola, ʻo ka lōʻihi loa he 16 hola. Hoʻopili ʻia ka waihona laea e nā keiki, kekahi ma nā ʻāpana o nā ʻāpana.

ʻO ka bioavailability o loaʻo Metformin ʻaʻole iʻoi aku ma mua o 60%. ʻAno ʻai nui ʻia i ka lohi ʻana o nā metformin. Hoʻokomo ʻia kahi waiwai i lawe ʻia ma loko o kahi ʻōpū ʻawa piha mai ka ʻōpū a me ka ʻōpū.

ʻAʻole e like me Glibenclamide, he palena paʻa loa me nā protein koko. Ke hoʻopio ʻia nei e nā ʻōpū. 30% o nā mea i hiki ke hele ma i nā feces o ka mea maʻi. ʻO ka hoʻopau hapa-hapalua ke ola i 12 mau hola.

Nā hōʻailona a me nā contraindications

ʻO ka hōʻike nui koʻikoʻi no ka lawe ʻana i kēia lāʻau lapaʻau ka hele ʻana o ke ʻano maʻi type II i ka mea maʻi. Pēlā nō, ʻo ka lāʻau lapaʻau i kauoha ʻia ai me ka ʻole o ka hopena kūpono o ka mālama ʻana me ka meaʻai, hoʻomaʻamaʻa a me nā maʻi e pili ana i ka lawe ʻana i ka Metformin me Glibenclamide.

Hoʻomaopopo ʻia ka lāʻau lapaʻau no nā poʻe maʻi me he kō koko koko maʻamau a paʻa mau, akā nāna nō e pono ke hoʻololi i ka lāʻau me Glibenclamide a me Metformin.

He helu nui o nā contraindications kekahi o nā lāʻau lapaʻau.

• pūpū hema
• kaohi koko haʻahaʻa (hypoglycemia),
• ka maʻi kiʻekiʻe loa i nā māhele o ka lāʻau lapaʻau,
• diabetes type II
• humuho waiwa,
• hapai
• impalired 'ōpala hana ma muli o nā maʻi, pīhoihoi,
• ketoacidosis
• lilo o ka miconazole,
• ka waiho ana o ku ana i ke kino,
• puʻuwai paʻakikī
• hana waiū
• nā maʻi like ʻole
• coma maʻi maʻi
• nā mālamalama maikaʻi ʻole
• myocardial infarction
• hoʻōki kūloko
• lactic acidosis,
• ka ʻalo ʻana i ka wai
• pauna aho hanu
• precoma maʻiʻaʻai
• maʻi maʻi phi.

ʻO nā maʻi maʻi a me nā Kuhina kūikawā

Lā ʻia kēia lāʻau lapaʻau no nā wahine hāpai. ʻAʻole hiki ke ʻae ʻia ka lawe ʻana i ka lāʻau lapaʻau ma ke kaʻina hana e pili ana i ka hāpai ʻana.

ʻAʻole pono nā Gluconorm e lawe ʻia e nā wahine lactating, no ka mea, ke komo ikaika ʻo Metformin i ka waiū umauma a hiki ke hoʻopilikia i ka olakino o ka pēpē. I kēia mau pilikia, ua hōʻike ʻia ke hoʻololi pono o ka lāʻau me ka inika insulin.

ʻAʻole ia ka mea i hōʻike ʻia e ka lāʻau no nā mea maʻi maʻi ʻoi aku o kona mau makahiki he 60 mau makahiki. I ka hui pū me nā ukana koʻikoʻi, hiki i Gluconorm ke hana i ka lactic acidosis i kēia māhele o ka poʻe.

Pono ka lāʻau lapaʻau e mālama pono e nā maʻi e loaʻa ana:

• lawa adrenal,
• fiva
• maʻi ʻehā.

No ka lāʻau lapaʻau, ua hāʻawi ʻia i nā ʻōlelo aʻoaʻo he nui:

• i ka wā o ka mālama ʻana, mālama pono ʻia ka nui o ka glucose o ke koko ma luna o ka ʻōpū ʻole a ma hope o ka ʻai ʻana,
• Ke ʻāpono ʻia ka lāʻau kuʻuna a me ka waiʻona
• pono e sui i ka lāʻau lapaʻau me ka inika insulin inā ua hōʻeha ʻia ka mea maʻi, nā maʻi, ka maʻi, ke ana, nā hana mua,
• 2 mau lā ma mua o ka hoʻolauna ʻana o kahi mea radiopaque e loaʻa ana i ka iodine i loko o ke kino o ka mea maʻi, pono ia e ʻae i ka lawe ʻana i ka lāʻau (ma hope o 2 mau lā, hoʻomau ʻia ke komo ʻana)
• ka hui pū ʻana o Gluconorm me ka ethanol e hoʻonāukiuki ana i ka hypoglycemia, loaʻa nō hoʻi ia i ka wā o ka pōloli a lawe i nā lāʻau anti-inflammatory o kahi ʻano like ʻole,
• Ka hopena ka lāʻau lapaʻau i hiki i ka mea maʻi ke holo i kahi kaʻa (pono ʻoe e hōʻole ma ka holo ʻana i ka kaʻa i ka wā o ka mālama ʻana me ka lāʻau lapaʻau).

ʻO nā manaʻo hoʻomanawanui

Nui nā loiloi o ka maʻi maʻi e pili ana i ka lālani Gluconorm i loaʻa ka hopena maikaʻi loa i ka lawe ʻana i ka lāʻau lapaʻau, eia naʻe, nā hopena koʻikoʻi ka mea i ʻōlelo ʻia, ma waena o nā nausea a me nā poʻo i nā manawa pinepine e hālāwai nei, e hoʻopau ʻia ana e ka hoʻoponopono hoʻoponopono ʻia.

Maikaʻi ka lāʻau lapaʻau, hoʻohaʻahaʻa ia i ke kō. ʻOi hou loa, ʻaʻole i loaʻa iaʻu kekahi hopena like ʻole i kākau pinepine ʻia e pili ana. ʻO ke kumu kūʻai kūpono. Kau i nā Gluconorm i kahi e mau nei.

Ua nui wau i ka maʻi maʻamau i ka maʻi maʻamau no nā makahiki he nui. Ua kuhikuhi iā ke kauka hele ʻana iā Gluconorm. I ka wā mua, aia nā hopena ʻaoʻao: pinepine ka maʻi, aia ka dizziness. Akā i ka wā e hiki mai ana mākou i hoʻoponopono iho i kēia maʻa, a ua hala nā mea a pau. He maikaʻi loa ka mea hana inā hoʻohui ʻoe i kāna hana me kahi meaʻai.

Kūpono loa ka Gluconorm. I koʻu hihia, ua kōkua hou wau e hoʻoponopono hou i ke kaumaha. ʻO ka lāʻau lapaʻau e hōʻemi i ka momona. ʻO nā mea liʻiliʻi, e hōʻike wau i nā hopena hopena. Nui nā mea o lākou. I kekahi manawa, maʻi ko kuʻu poʻo a me ka maʻi.

ʻAʻole i ka manawa ma mua, ua hana kahi endocrinologist i kahi maʻi ʻino - type 2 type diabetes. Ua kuhikuhi ʻia ʻo Gluconorm e hoʻoponopono i ke kōʻai koko. ʻO ka hauʻoli piha loa i ka mālama ʻana. Me ke kōʻai gula nui, hiki i ka lāʻau lapaʻau ke hōʻemi i kona pae i 6 mmol / L. Aia kekahi mau hopena ʻaoʻao, akā ua hoʻopau ʻia lākou. Pono ke ʻai.

ʻO nā kumukūʻai o ka gluconorm ma nā wahi like ʻole o ka'āina ʻē. ʻO ka kumukūʻai kumukūʻai ma ka'āina he 212 mau rubles. ʻO ka kumukūʻai o ka lāʻau lapaʻau he 130-294 mau rubles.