He aha ka paleʻana o ka insulin: nā hōʻailona a me ka mālama

ʻO ka paleʻana i ka insulin he hoʻonā i nā pane kūlohelohe o nā kino kino i ka hana o ka insulin. ʻAʻole mea koʻikoʻi ka mea e hele mai ai ka insulin, mai ka pancreas (endogenous) a mai nā injections (exogenous).

Hoʻonui ka resistulin inulin i ka hopena o ka maʻi maʻamau o ka type 2 wale nō, akā ʻo ka atherosclerosis, hōʻeuʻeu ka puʻuwai, a me ka make koke ma muli o ka moku i kahaka.

ʻO ka hana ʻana o ka insulin ka hoʻoponopono ʻana i ka metabolism (ʻaʻole wale nō ka momona, akā ke momona a me nā protein), a me nā kaʻina mitogen - ʻo ia ka ulu ʻana, ka hoʻopiʻi o nā pūpū, DNA synthesis, gene transcription.

ʻAʻole ʻae ʻia ka manaʻo o kēia mau ʻenehana i ka insulin i ka maʻi metabolism e hoʻonui ʻia ana a he nui ka hoʻonui ʻia ʻana o ka maʻi diabetes type 2. Hoʻopili pū kekahi me nā loli i ka hana o nā momona, nā palapa, ka hōʻike gen. I ka pilikino, ʻo ka pale ʻana i ka insulin e alakaʻi i nā pilikia me nā cell endothelial e uhi nei i nā paia o nā kīʻaha koko mai loko. Ma muli o kēia, ke kani nei ka lumen o nā moku, a holomua ka atherosclerosis.

Nā hōʻailona o ke kū'ē o ka insulin a me ke nānāʻana

Hiki iā ʻoe ke kānalua i ka loaʻa ʻana o ka insulin e kū ʻole inā e ʻike kāu mau hōʻailona a me / a i ʻole nā hōʻike i ʻike ʻoe i ka metabolic syndrome. Aia i ka:

huanā ma ka hope (ʻōpū),
ʻaina (ke kiʻekiʻe o ke koko),
nā hewa koko ʻaʻai no ka cholesterol a me ka triglycerides,
ka ʻike ʻana i ka protein i loko o ka urine.

ʻO ka momona homdominal ka hōʻailona maʻamau o ka pale ʻana i ka insulin. I ka lua o ka wahi a me ka anuʻu hypertension (kiʻekiʻe koko). ʻAʻole kaʻai iki, ʻaʻohe kanaka i loaʻa i ka pohō a me ke hypertension, akā ua maikaʻi ʻole nā hoʻāʻo ʻana o ke koko no ke kolamu a me nā momona.

Ma muli o ke kū ʻana o ka pale ʻana ma ka hoʻohana ʻana i nā hoʻokolohua. No ka mea hiki ke hoʻololi like i ka insulin o ka plasma koko, a he mea maʻamau kēia. Ke ʻimi nei i ka ʻaina plasma wela, ke kū nei ka maʻamau mai 3 a 28 mcU / ml. Inā ʻoi aku ka nui o ka insulin ma mua o ka hoʻokeʻo koko, ʻo ia ka mea i loaʻa i ka hyperinsulinism.

Hoʻonui ka hoʻonui ʻana o ka insulin i ke koko i ka wā e hoʻoulu ai ka pancreas i kahi nui o ia mea e hiki ai ke hoʻopiʻi i ka kū ʻana o ka kū i ka insulin i nā kiko. Hōʻike ka hopena o kēia hōʻike ma ka nui o ka maʻi o ka mea maʻi me ke ʻano maʻi type 2 a me / a me nā maʻi maʻi cardiovascular.

ʻO ke ala kūpono loa no ka hoʻoholo ʻana i ka kūleʻa o ka insulin i kapa ʻia ʻo ka pipi clins insulin. Hoʻokomo ia i ka hoʻomohala kūlohelohe o ka insulin a me ka glucose i nā hola 4-6. He hana paʻakikī kēia, a no laila maʻamau ka hoʻohana pinepineʻana i ka hoʻomaʻamaʻa. Hoʻohālikelike lākou i nā hoʻāʻo ʻana i ke koko no nā pae insulin plasma.

Ua hōʻike ʻia nā haʻawina ua loaʻa ka kū ʻana o ka insulin:

10% o nā kānaka a pau me ka pilikia ʻole.
ma 58% o nā mea maʻi me ka maʻi maʻi (ke koko o ke koko ma luna o 160/95 mm Hg),
i loko o 63% o ka poʻe me ka hyperuricemia (serum uric acid ʻoi aku ma mua o 416 μmol / l ma nā kāne a ma luna o 387 mol / l i nā wahine),
i loko o ka 84% o nā poʻe me nā ʻaina koko kiʻekiʻe (triglycerides nui ma mua o 2.85 mmol / l),
i 88% o nā poʻe me ka haʻahaʻa o ka cholesterol "maikaʻi" ma lalo o 0.9 mmol / l i nā kāne a ma lalo o ka 1.0 mmol / l i nā wahine),
i loko o ka 84% o nā mea maʻi me ka maʻi diabetes type 2,
66% o ka poʻe me ka hoʻomanawanui i ka hoʻohaʻahaʻa glucose.

Ke lawe ʻoe i kahi hoʻāʻo koko no kolesterol - mai hōʻoia i nā kolamu holoʻokoʻa, akā "ʻokoʻa" maikaʻi a "maikaʻi ʻole".

Pehea e hoʻoponopono ai ka insulin i ka metabolism

ʻO ka mea maʻamau, kahi molika o ka lālani e paʻa ai i kāna mea lawe i ka ʻā o nā pūpuna i ka ʻāʻī o ka ʻiʻo, ka momona, a i ʻole a me nā iwi momona. Ma hope o kēia, autophosphorylation o ka mea nāna i hopu i ka insulin me ke komo ʻana o nā kinase tyrosine a me kāna pili ʻana aʻe me ka substrate o ka receptor insulin 1 a i ʻole 2 (IRS-1 a me 2).

Nā molekula IRS, ma ka huli ʻana, hoʻolaʻa i ka phosphatidylinositol-3-kinase, e hoʻoikaika ana i ka unuhi ʻana o GLUT-4. ʻO ia kahi mea lawe i ka glucose i loko o ka pūnaewele ma o ka membrane. Hāʻawi ʻia ia mau hana i ka hana o ka metabolic (kaʻea glucose, synthesis glycogen) a me nā hopena mologen (DNA synthes).

Hoʻopuka ʻia ka huaʻai ʻana e nā aʻa o nā mākia, nā aʻa a me nā iwi adipose.
Synthesis o glycogen i loko o ka ate (ka waihoʻana o ka "wikiwiki" glucose i mālama ʻia)
ʻO ka hopu ʻana i nā waikawa amino e nā pūlima,
Nā huina DNA
Nā kāpili protein
ʻO kaʻili momona momona
Ke lawe ʻana i loko.

Lipolysis (ka haki o ka kiko adipose me ke komo ʻana o nā momona momona i ke koko),
ʻO Gluconeogenesis (hoʻololi i ka glycogen i loko o ka ate a me ka glucose i loko o ke koko),
Apoptosis (pepehi ʻia iho a koe o nā pūlaka).

Hoʻomaopopo i ka hana ʻana i ka insulin i ka ʻakiʻaka o ka iwi adipose. ʻO ia ke kumu, inā hoʻokiʻekiʻe ka pae o ka insulin i ke koko (ʻo ka hyperinsulinism kahi hanana pinepine me ka pale ʻana i ka insulin), a laila paʻakikī loa ka lilo ʻana o ka paona, kokoke hiki ʻole.

Nā kumu genetic ke kū i ka insulin

ʻO ka paleʻana i ka insulin kahi pilikia o ka pakeneka nui o nā kānaka a pau. Ke manaʻoʻiʻo ʻia nei nā maʻi ia e nā ʻenehana i lilo i mea nui i ka wā o ka hoʻokalakupua. I ka makahiki 1962, ua hōʻano 'ole' ia ka palekana o ka insulin he mea ola i ka wā o ka pōloli lōʻihi. No ka mea e hoʻomaikaʻi nei i ka hōʻiliʻili ʻana o ka momona i ke kino i nā manawa o ka nui o kaʻai.

Kuhi ʻia nā ʻepekema ʻikepika i nā lā lōʻihi. ʻO ka poʻe lōʻihi e ola ana ka poʻe i loaʻa i ka kūlohelohe kūloko kūloko ʻōlima. ʻO ka mea pōʻino, i nā kūlana o kēia wā, ʻo ka hana o ka pale ʻana i ka insulin e "hana" no ka ulu ʻana o ka momona, hypertension a me ka maʻi type 2.

Ua hōʻike nā noiʻi i nā maʻi me ka maʻi type type 2 i loaʻa nā maʻi genetic i ka hoʻoili hōʻailona ma hope o ka hoʻopili ʻana i ka insulin me kā lākou mea i hopu. Ua kapa ʻia kēia mau hemahema postreceptor. ʻO ka mea mua, ua hōʻole ʻia ka unuhi ʻana o ka transporter glucose GLUT-4.

I nā mea maʻi me ka maʻi type 2, ʻike ʻia nā mea ʻē aʻe e hāʻawi ai i ka metabolism o nā glucose a me nā lipids (nā ʻāpana). ʻO kēia nā genes no ka dehydrogenase glucose-6-phosphate, glucokinase, lipoprotein lipase, fatty acid synthase a me nā mea ʻē aʻe.

Inā loaʻa kekahi kanaka i ka predisposition genetic i ka hoʻomohala ʻana i ke ʻano type type 2, a laila hiki ke hoʻomaopopo ʻia a ʻaʻole paha e kumu i ka metabolic syndrome a me ka maʻi diabetes. Aia nō i ke ʻano ola. ʻO nā mea koʻikoʻi nui ka mea nui o ka ʻai, ʻoi aku ka nui o ka ʻai ʻana i nā haʻalulu (hoʻolioli a me ka palaoa), a me ka hana haʻahaʻa haʻahaʻa.

He aha ka manaʻo o ka insulin i nā umauma kino a pau

No ka mālamaʻana i nā maʻi, ka naʻau o ka insulin e pili ana i ka pūpū a me ka kiko adipose, a me nā pūpuna o nā pona he mea nui loa. Akā aneʻa ka pae o ka pale ʻana o ka insulin i kēia mau kiko? I ka 1999, ua hōʻike i nā hoʻokolohua ʻaʻole.

ʻO ka maʻamau, ʻo ke kāohi i ka 50% o lipolysis (hōʻeha momona) i loko o ka kiko adipose, kahi lawa o ka insulin i ke koko ʻaʻole iʻoi aku ma mua o 10 mcED / ml. No ka 50% o ka hoʻokuʻu ʻana o ka hoʻokuʻu ʻana i ka glucose i loko o ke koko e ka maʻa, ma kahi o 30 mcED / ml o ka insulin i ke koko ua koi ʻia. A i mea e hoʻonui i ka haki nui o ka glucose e nā kikoʻī o ka maʻa ma o 50%, kahi paʻa o ka insulin i loko o ke koko o 100 mcED / ml a me ke kiʻekiʻe e pono ai.

Hoʻomaopopo mākou iā ʻoe ʻo ka lipolysis ka haki o ka kiko adipose. Hoʻopaʻa ka hana a ka insulin, e like me ka hoʻāla ʻana o ka glucose i ka ate. A keʻike nei ka ʻōlohelohe o kaʻumeka e ka insulin, i ka ʻokoʻa, ua hoʻonui ʻia. E noʻonoʻo, ma ka type 2 diabetes mellitus, nā huaʻelima i hōʻike ʻia o ka ʻike nui o ka insulin i ka koko ua hoʻololi ʻia i ka pono, i.e., i ka piʻi ʻana o ka kū i ka insulin. Hoʻomaka kēia kaʻina hana ma mua o ka hōʻike ʻana o ke diabetes iā ia iho.

ʻO ka hoʻohaʻahaʻa ʻana o nā ʻuhane o ke kino i ka insulin e hōʻemi ma muli o kahi predisposition genetic, a ʻo ka mea nui loa - ma muli o ke ʻano nohona maikaʻi ʻole. I ka hopena, ma hope o nā makahiki he nui, pau ka pancreas i ke kūpaʻa i ka piʻo nui. A laila huli lākou i ka maʻi "type" maoli 2. He mea nui ka pōmaikaʻi loa i ka mea maʻi inā hoʻomaka ka mālama ʻana i ka metabolic syndrome e like me ka mea hiki.

He aha ka ʻokoʻa ma waena o ka pale ʻana o ka insulin a me ka metabolic syndrome

E makaʻala ʻoe e pili ana ka pale ʻana o ka insulin i ka poʻe me nā pilikia olakino ʻaʻole ʻia me ka manaʻo o ka "metabolic syndrome". I kēia:

polycystic ovary i ka wahine,
uhaola hooulu pila
nā maʻi ʻohi
nā hoʻonā glucocorticoid.

Hoʻokomo ʻia ka pale kūlohelohe i ka wā hāpai, a hala ma hope o ka hānau keiki. He ala ʻokoʻa hoʻi ia me ka makahiki. A e hilinaʻi ia i ke ʻano o ke ola a kahi ʻelemakule e alakaʻi ai, ʻo ia nō e hoʻoulu i nā ʻano maʻi maʻamau a me / a i ʻole nā pilikia cardiovascular. Ma ka ʻatikala "Ma ka maʻi hānai ma nā ʻelemakule" ʻike ʻoe i nā ʻike maikaʻi loa.

ʻO ka paleʻana i ka insulin ke kumu o ka maʻi diabetes 2 ʻano

Ma ke ʻano 2 diabetes mellitus, ka pale ʻana i ka lā o nā ʻōpū o nā ʻōpū o ka naʻau, ka pehu a me ka iwi adipose ka nui o ka nui o ka lāʻau nui. Ma muli o ka nalowale o ka hōʻiliʻiliʻana i ka insulin, ua emi iho ka glucose i ka "ʻā." I loko o ka pu, no ia kumu like, ua hoʻoneʻe ʻia ka decompposation o ka glycogen i ka glucose (glycogenolysis), a me ke ʻano o ka hoʻokaʻina o ka glucose mai nā waikena amino a me nā "waiwai ʻona" (gluconeogenesis).

Hōʻike ʻia ka hoʻonaninaniʻana o ka insulin adipose i ka ʻoiaʻiʻo i ka hopena antilipolytic nāwaliwali o ka insulin. I ka manawa mua, ua hōʻole ʻia kēia e ka hoʻonui ʻana o ka hana insulin pancreatic. I nā papa hope o nā maʻi, ʻoi aku ka nui o ka momona i ka glycerin a me nā momona momona i loaʻa. Akā i loko o kēia manawa, ʻaʻole e hoʻoluhi ke kaumaha i ka hauʻoli nui.

Hele nā glycerin a me nā momona momona i loko o ke ate, kahi e kūleʻa ai nā lipoproteins haʻahaʻa loa mai lākou. ʻO kēia mau mea ʻinoʻino i waiho ʻia ma nā paia o nā moku koko, a holomua ka atherosclerosis. ʻO ka nui o nā pulu o ka glucose, e kū mai ana ma muli o ka glycogenolysis a me ka gluconeogenesis, ke komo aku nei i ke kahe mai ke akea.

ʻO ka paleʻana o ka insulin a me nā hōʻailona o ka metabolic syndrome i ke kanaka e hoʻomohala i mua o ka hoʻomohala ʻana o ka maʻi mellitus. No ka mea, ua hoʻopaʻi ʻia ka pale o ka insulin i nā makahiki he nui e ka hoʻonui ʻia ʻana o ka insulin e nā beta beta o ka pancreas. I kēlā kūlana, ua ʻike ʻia ka piʻi ʻana o ka insulin i loko o ke koko - hyperinsulinemia.

ʻO ka Hyperinsulinemia me ke kaila koko maʻamau he hōʻailona ia o ka kū ʻana o ka insulin a me kahi harbinger o ka hoʻolālā ʻana i ka maʻi type 2. I ka hala ʻana o ka manawa, ʻaʻole i hui nā pancreatic beta i nā ukana no ka hoʻopiʻi ʻana i ka kū i ka insulin. Hoʻopili lākou i ka emi a me ka liʻiliʻi o ka insulin, he nui ke kō me ke kō koko a me ka maʻi diabetes.

ʻO ka mea mua, ʻeha ka 1st 1st o ka huna ʻona o ka insulin, i.e., kahi kaila wikiwiki i ka insulin i loko o ke koko i ka pane ʻana mai i ka ʻai kai. A ʻo ka basal (ʻili) ʻo ka huna ʻia o ka insulin e mau loa. Ke piʻi nei ke kiʻekiʻe o ke koko koko, e hoʻonui kēia i ka hoʻonaninaki insulin a me ka pale ʻana i nā hana o nā poli beta i ka huna ʻana o ka insulin. Kapa ʻia kēia ʻano hana no ka hoʻomohala ʻana i ka maʻi diabetes.

ʻO ka paleʻana a me ka ikehu cardiovascular

Ua ʻike ʻia ma nā mea maʻi me ka diabetes type 2, hoʻonui ʻia ke ʻano maʻi cardiovascular e nā manawa 3-4, ke hoʻohālikelike ʻia me nā poʻe me ka ʻole o ka maʻi pānaʻi. Ke koi aʻike nei nā poʻe ʻepekema a me nā mea lapaʻau i ka pale ʻana o ka insulin a, pū pū me ia, he pilikia koʻikoʻi nui ka hyperinsulinemia no ka hōʻeha ʻana i ka naʻau a me ka ʻeha. Eia nō naʻe, ʻaʻole hilinaʻi kēia pilikia inā ua hāpai ka mea maʻi i ka maʻi diabetes a ʻole paha.

Mai ka 1980s, ua hōʻike nā noiʻi ua loaʻa ka insulin i ka hopena atherogenic pololei ma nā paia o nā kahe koko. ʻO kēia ke kumu a me ka pilakē atherosclerotic a me ka hoʻopili ʻana i ka lumen o nā moku e holomua ma lalo o ka hana o ka insulin i ke koko e kahe ana ma o lākou.

Hoʻokomo ʻia ka Insulin i ka hoʻomaʻamaʻa ʻana a me ka neʻe ʻana o nā pūnao māhuahua o ka naʻau, ke kō ʻana o nā lipids ma loko o lākou, ka hoʻomaikaʻi ʻana o nā fibroblasts, ka hoʻōla ʻana o ka ʻōnaehana coagulation koko, a me nā kaola o ka hana fibrinolysis. No laila, ʻo ka hyperinsulinemia (ka nui o ka neʻe ʻana o ka insulin i loko o ke koko ma muli o ka pale ʻana i ka insulin) he kumu nui ia o ka hoʻomohala ʻana o ka atherosclerosis. Hōʻike koke kēia i ka lōʻihi o ke ʻano o nā maʻi diabetes type 2 i ka mea maʻi.

Hōʻike nā haʻawina i kahi pilina pololei ma waena o ke kiʻekiʻe o ka pale ʻana i ka insulin a me nā mea kūʻē no ka maʻi cardiovascular. Ke alakaʻi nei ka insulin i ka mea kūpono:

hoonui ae i ka hanu,
ua piʻo ke kaila kolamu a ke koko, a me nā pāpaʻi mai ka puka kino o ka "kino" ma luna o nā paia o nā kīʻaha koko,
nui ka loli o ke koko i nā moku,
lilo ka pā o ka ʻili o ka carotid maʻa (ʻo ka lumen o ka pā kani ka pili).

Ua hōʻike ʻia kēia pilina paʻa i loko o nā mea maʻi me ka diabetes type 2 a me nā mea ʻole me ke ʻole.

Ho'ōla kino kūlohelohe

ʻO kahi ala e mālama ai i ka kūʻē o ka insulin i nā manawa mua o ke ʻano maʻi type 2, a ʻoi aku ka maikaʻi ma mua o ka ulu ʻana, ʻo ke hoʻohana ʻana i kahi kīpē e hoʻopau ai i nā kao i kāu mau meaʻai. ʻO ke kūpono, ʻaʻole kēia ke ala e mālama ai i ka kū ʻana o ka insulin, akā e hoʻokipa wale nō. ʻO kaʻai haʻahaʻa-liʻiliʻi me ka pale ʻana i ka insulin - pono e hoʻopili ʻia ia no ke ola.

Ma hope o nā lā 3-4 o kaʻai ʻana i ka meaʻai o ka pale ʻana i ka insulin, ʻike ka hapa nui o ka poʻe i kahi holomua o ko lākou mālama maikaʻi. Ma hope o nā hebedoma he 6 mau wiki, hōʻike ʻia nā hoʻokolohua ʻo ka "maikaʻi" kolamu i loko o ke koko e piʻi a hāʻule ka "maikaʻi". A i ka pae o ka triglycerides i ke koko e hāʻule i ka maʻamau. ʻO kēia ka mea i hoʻemi iki ka hopena o ka atherosclerosis i mau manawa.

ʻAʻole he mau lāʻau lapaʻau maoli no ka pale ʻana i ka insulin. Ke hana nei nā loea i ka loiloi a me ka biology ma kēia. Hiki iā ʻoe ke hoʻomālamalama maikaʻi i ke kū ʻana o ka insulin ma o ka hahai ʻana i ka ʻai haʻahaʻa. ʻO ka mea mua, pono ʻoe e hoʻokaʻawale i ka ʻai ʻana i nā ʻaina hoʻoneʻe, ʻo ia ka ʻohi, ke kō, nā lole a me nā huahana palaoa keʻokeʻo.

Me ka kū'ē o ka insulin, ʻo ka metformin (siofor, glucophage) e hāʻawi i nā hopena maikaʻi. Hoʻohana ia ma ka hoʻohui ʻana i ka meaʻai, a ʻaʻole ia ma ia mea, a e kamaʻilio me kāu kauka mua e pili ana i ka lawe ʻana i nā lāʻau. Hoʻopau mākou i kēlā me kēia lā i ka lono i ka mālama ʻana i ka kūʻē o ka insulin. Hana nā genetics a me nā microbiology i nā hana mana maoli. A ke lana nei nā mana i loko o nā makahiki e hiki mai ana e hiki iā lākou ke hoʻokō hou i kēia pilikia. Inā makemake ʻoe e ʻike mua, e kākau inoa i kā mākou newsletter, e kaʻawale.

He aha ke kū'ē i ka insulin

Term Ke kū'ē i ka insulin ke kuhikuhi i ka hiki ʻole o nā ʻōpū o ke kino i pane ai i ka insulin hormone. ^ E Ha yM. ʻO ka hiki ʻole o nā pūlima e nakinaki i ka hormone a, no laila, pane i kāna hōʻailona e alakaʻi i ka ʻike ʻole i ka maikaʻi o ka glucose i nā ʻāpono.

Ke alakaʻi nei kēia hoʻonui i nā glucose koko a, ma ka manawa like, piʻi ka pae hui kokono ka mea ʻaʻole hiki ke hoʻohana pono i ka hormone.

He aha ke ʻano o kēia kūlana?

Nā kumu: ʻoi aku ka huna ʻana i ka insulin a i ʻole ka ira

Hoʻopili i nā hoʻonā wai pili pili i ka hana ʻana i ka insulin mai nā papa beta o ka pancreas. Loaʻa i nā sela o ko mākou kino ke loaʻa i ka insulin receptors e kū ana i nā membrane cell, kahi e ʻae ai mākou i ka hoʻōla i ka hana o ka halihali a me ka hoʻoliʻiliʻi o ka honu e nā puna.

Eia nō naʻe, i kekahi mau hihia, ʻaʻole hiki i nā papa ke pane i ka insulin.

Ka Hoʻololi Kūʻai Kūʻai: i ka wā e loaʻa ai ka nui o ka insulin mai ka pancreas ma muli o nā kumu like ʻole, no ka laʻana, he ʻano mau i ka nui o ke kō o ke koko ma o nā pono kūpono.
Kēlā genetic: i ka wā e nānā ai nā mea ʻalopona e kau ana ma luna o ke kelepona he ira genetic a luku ʻia e nā antibodies.

Pae A i ole type B e pale kū i

ʻOiai ke kū kaʻe ʻana o ka insulin i ka hopena hoʻokahi, i.e. ka hana ʻole o nā pū e pane ai i ka insulin, hiki i nā mea like ʻole ʻelua:

Kahi i kahi kū'ē kū i ka insulin: nā mea maʻamau, pili i nā maʻi e like me ka metabolic syndrome, type 2 diabetes and polycystic ovaries.
Kūleʻa kūpaʻa B: kahi ʻano maʻamau o ka maʻi, i kahi ʻano pale. ʻO kahi hiʻohiʻona o ka hele ʻana o nā antibodies e kū'ē i nā receptors insulin.

He aha nā palena i loko o ka waiwai o ka insulin i loko o nā palena maʻamau?

ʻO nā hōʻike a me nā loiloi loiloi no ka maʻi maʻi

ʻO ka waiwai pae kiʻekiʻe hui koko aia nā 6-29 μl / ml. Hoʻomaka ʻia ka Diagnosis o ka pale ʻana i ka insulin me ka hoʻohana ʻana i nā ʻano loiloi like ʻole, ʻo ka ʻenekia a me nā hoʻopaʻa haʻawina paha.

E like me nā haʻawina hoʻokolohua, ʻo nā manaʻo kikoʻī no ka pale ʻana i ka insulin:

Hōʻike Hyperinsulinemic-Euglycemic: hiki iā ʻoe ke koho i ka nui o ka glucose e pono ai e hoʻopiʻi no ka hoʻonui ʻana i ka insulin me ka ʻole o ka hypoglycemia.
Hōʻike hoʻoliʻi Insulin: kahi hoʻokolohua lapaʻau e hana nei ma o kahi hōʻike hoʻokolohua.

ʻOiai he kūpono kēia mau kaʻina, ʻike paʻakikī loa e hoʻohana no nā kumu maʻi, ua hoʻohana ʻia lākou no nā kumu ʻepekema.

Ma nā hana lapaʻau i kēlā me kēia lā, ma kahi, ua hoʻohana ʻia nā ʻano ʻoi aʻe:

ʻO ka nānā hoʻomanawanui: ʻO nā mea maʻi me ka momona a i ʻole ka loaʻa ʻana o ka ʻāʻī e ʻoi aku ma mua o ka maʻamau ke kū pinepine ʻia ka insulin.
Na hōʻike hōʻike hoʻokaumaha: e hana ana ma o ke ana ʻana i ka ʻai o ka glucose i ke koko ma ka ʻōpū ʻole a ma hope o ka lawe ʻana o 75 g o glucose i loko.
Kūhi a Insulin: ka ana ana i ka leʻaleʻa i ka ʻikepili insulin, ma ka ʻōpū ʻole a ma hope o ka ʻai ʻana. Hoʻāʻohi pinepine ʻia ia me ka ʻūhā waha ukala waha.
Hōʻike HOMA: kahi kikoʻī koʻikoʻi no ka loiloi ʻana i ka pale ʻana i ka insulin ʻo ka HOMA index (Homeostasis Model Assement).

ʻO nā mea hiki ke kumu e hoʻonui i ke kū'ē i ka insulin

He ʻokoʻa nā kumu o ka pale ʻana o ka insulin, akā e alakaʻi mau i ka hiki ʻole o nā pūleau e pane i ka insulin hormone:

ʻO ka kaiʻai a me ka nohona: ka hemahema, ka mea e loaʻa ai ka nui o nā meli māmā, nā ʻono a me nā mea momona momona, a ke ʻano kanu e hiki ai a me ka loaʻa ʻole o ka hoʻomaʻamaʻa ʻana nā kūlana e wānana i ka hoʻomohala ʻana i ka metabolic syndrome, obesity a me ka pale ʻana i ka insulin.
Nā genetics: I kekahi mau manawa, aia nā hemahema genetic i loko o nā ʻĀina insulin, ka hopena, ʻaʻole i hana pono. ʻO kekahi mau maʻi pediatric, e like me Donoghue syndrome a me Rabson-Mendenhall syndrome, ka mea e hoʻoholo ai i ka kūleʻa o ka insulin i nā keiki, hiki ke hōʻike ʻia i kahi mea hoʻohālike.
Immunology: Nā papa hana imune e hoʻokūkū i nā antibodies e hana kūʻē i nā ʻenehana insulin. I kēia lā, ʻaʻole maopopo loa kēia mau ʻano hana, akā ke alakaʻi nei lākou i ke ʻano kū'ē o ka insulin B.
Nā valaau nui: ʻO kekahi mau pilikia endocrine, e like me Cush's syndrome a acromegaly, ke hoʻoholo nei i ka hoʻomohala ʻana o ka kūleʻa o ka insulin, e like me nā nui e like me ka GH (ulu i ka nui o ka hormone), cortisol a me nā glucocorticoids, kahi mau antagonis insulin.
ʻO nā Tumors: ʻO kekahi o nā tumors, e like me pheochromocytoma a me glucagon, e hoʻoholo i ka hana o nā nui nui o nā hormones, antagonist o nā insulin.
Hoʻomaka: Hiki i nā corticosteroids a i nā ulu ulu ʻana (GH) e alakaʻi i ka kūʻai o ka insulin.

Pono e hoʻomanaʻo ʻia he mau maʻi hiki ke kumu a, ma ka manawa like, he hopena o ka kūʻē o ka insulin, e like me kā mākou e ʻike ai ma ka māhele aʻe.

Nā hōʻailona hōʻailona me ka pale ʻana i ka insulin

ʻO ke ʻano nui o ka pale ʻana i ka insulin hoʻonui i ka glucose koko, i.e. ʻo ka hyperglycemia a me ka hoʻonui ʻana o ke koko o ka insulin (hyperinsulinemia), kahi e pili ai i nā hōʻailona e like me ka luhi, ka hiamoe, a me ka nāwaliwali ākea.

Eia nō naʻe, aia kekahi mau ʻano ʻē aʻe e superimped ana i nā hopena, a i kekahi manawa ke kumu o kēia pilikia, e uhi ana i nā hui āpau a me nā ʻōnaehana, i nā kikoʻī.

Mai ka ʻōnaehana hana hānau: Ke alakaʻi nei ka palena o ka insulin i kahi kūlana o ka hyperandrogenism, ʻo ia hoʻi, he nui o nā kāne kāne o ka nui o nā kāne kāne i ka wahine. Hiki i kēia ke alakaʻi i ka infertility, amenorrhea, a me nā maʻi like e like me ka polycystic ovary syndrome. Inā kū i ka insulin i ka wā o ka hapai, hiki ke loaʻa ka male ʻana, ʻoi aku hoʻi i nā mahina mua o ka hānau ʻana. ʻO ka menopause, he hopena pili i ka hoʻomohala o ka metabolic syndrome, hiki ke alakaʻi i ka kū'ē o ka insulin, me ka mea he hoʻololi i ka metabolism ma muli o ka nele o ka estrogen.
ʻO ka momona Metidism Fat: ke kū'ē o ka insulin i nā hoʻololi o ke kaohi ʻana o nā momona momona. I ka nui, holo ka nui o nā huikua momona manuahi i ke kino, e hele mai ana mai ka nui o ka glucose i loko o ke koko. Hoʻoholo kēia i nā hopena like ʻole ma ka pae o ka kiko adipose: ʻo ka hōʻiliʻili o ka momona momona e alakaʻi i ka loaʻa o ka momona a me ka hoʻoneʻeʻana o ka momona i ka ʻōpū o ka ʻōpū, ka huakaʻi o ka ate, a ma ka pae o ka hāhi e hoʻonui ai i ka hiki ke hoʻomohala ʻana i ka atherosclerosis.
ʻŌnaehana Cardiovascular: Hiki i ke kūlohelohe kumu ke pilikia i nā pilikia cardiovascular, e like me ka hoʻonui ʻana i ke koko i kumu ʻia e ka piʻi ʻana o ka paʻakai sodium ma muli o ka hyperinsulinemia, ka hoʻokumu ʻana i nā pākiki momona i nā kīʻaha e hōʻemi i ke kahe o ke koko i ka puʻuwai.
Nā ʻōhua o ka ʻili: ʻO kekahi o nā hiʻohiʻona o ka pale ʻana i ka insulin ko ka hoʻomohala ʻana i nā ʻōiwi ʻili i kapa ʻia ka acanthosis, ka mea e hōʻoli ai i nā ʻili o ka ʻili, e lilo i wahiʻeleʻele a lahilahi. Eia nō naʻe, ʻaʻole maopopo ka ʻano o ke kamaʻilio ʻana me ka pale ʻana i ka insulin.
ʻAno maʻi type 2: ʻO ka hopena maʻamau loa. Ua hōʻike ʻia ʻo ia iho e like me nā hōʻailona maʻamau o ka maʻi maʻi, e like me ka make nui o ka make ʻana, ka hoʻohaʻaka pinepine ʻana, nā luhi, nā haunaele.
ʻO nā hopena ʻē aʻe: Ma waena o nā hopena o ke kū'ē o ka insulin, ka hiʻohiʻona o ka huehue, ka mea pili me ka polycystic ovary syndrome a me ka hyperandrogenism, lauoho lauoho, pili pū kekahi me ka hoʻonui ʻana o ka androgens.

Hoʻolohe Hiki ke pili me ka kūlohelohe i ka ʻōpū maʻi e aeʻoiai ʻaʻole ia he hopena kumu. No ka laʻana, ua pili pinepine ka pale ʻana i ka lā nui me ka huelo a me nā maʻi thyroid, e like me ka hypothyroidism, ka mea e hoʻolōʻihi i ka metabolism a hoʻonui i ka manaʻo e hōʻemi i ka momona, a pili pū hoʻi ka pale kūʻē o ka insulin me ka hiki ʻole o ka pale a me ka atherosclerosis.

Pehea e kū hou ai ka pale ʻana i ka insulin?

ʻO ka kū'ē o ka insulin, ka mea e hoʻopili ʻia ai e ka meaʻai, nā mea kanu, a i ʻole ke hōʻemi ʻana i ka hormonal, e mālama ʻia me nā mea kanu maoli e kū pono ana i ka lāʻau a me ka lāʻau e kōkua ai i ka hoʻouka ʻia ʻana o kēia maʻi.

I mea e ʻike ai i ka hopena o ka kū ʻana o ka insulin, pono ʻoe e ʻimi i ke kauka e hoʻomaikaʻi i ka lāʻau i kūpono, ʻo ia ke kumu o ka pilikia. A ke hāʻawi aku nei mākou iā ʻoe i kāu ʻōlelo!

Hōʻalo i ka paleʻana i ka insulin: ka papaʻai a me ka hana

ʻO kaʻai maʻamau ka mea nui i nā hana nui no ka poʻe e ʻeha i ka pale ʻana i ka insulin e pili ana i ka metabolic syndrome. I ka ʻoiaʻiʻo, ʻo nā kīʻaha mānoanoa ʻole a me nā mea kau e pili ana i ka momona a me ka obesity ka kumu mua o ke kūʻē o ka insulin.

No laila, he mea nui ka luhi o ka paona no ka ho'ōla. No laila, aia kekahi mau huahana i makemake ʻia a me nā mea ʻē aʻe e pono ke pale ʻia.

Nā huahana Hana: ʻO nā meaʻai me kahi haʻahaʻa glycemic index, ʻo ia hoʻi, e hoʻolōʻihi i ka nui o ke kō koko koko, a no laila e kaupalena i ka pōloli ma luna o ka manawa, he mea nui loa. No ka laʻana, ka palaoa-pālua, ʻaila mauʻano liʻiliʻi, nā huahana paʻakai haʻahaʻa, waiū skim. E makemake ʻia nā ʻiʻo a me nā iʻa.
Meaʻai e pale ai: ʻO nā meaʻai a pau e kumu i ka mahuahua o ka mahuahua o ke koko, e like me ka pastry, ka huina maʻalahi, nā berena a me ka pasta mai ka palaoa lae, pono e pale ʻia. ʻO ka momona momona, nā mea inu momona carbonated, nā mea inu wai, a me kekahi mau huaʻolima glycemic indexally e like me ka ʻuala a me nā kaloti e pono hoʻi e kaupalena ʻia.

ʻOiʻa hoʻi ka mea nui ka hana kino kūponohana i kēlā me kēia lā a ʻekolu mau manawa i ka hebedoma e hoʻolaha i ka hoʻolilo ʻana.

Kālea lāʻau 1

1 kuli o ka lau palakeke,
1 punetēpō o ka hua kao puaa
30 g o nā lau walnut
1 hapauai o nā hua dill.

Pono e hoʻopili ʻia ka ʻano kō i ka wai e hoʻolapalapa ai he ʻumi mau minuke, a laila kānana a inu ʻia a ʻekolu mau manawa i ka lā.

ʻO ke kumu o ka maʻi diabetes 2

Hoʻomaka ka hōʻailona o ka metabolic syndrome i ke kanaka ma mua o ka hoʻomohala ʻana o ka maʻi diabetes. No ka mea, ua hoʻopaʻi ʻia ka pale o ka insulin i nā makahiki he nui e ka hoʻonui ʻia ʻana o ka insulin e nā beta beta o ka pancreas. I kēlā kūlana, ua ʻike ʻia ka piʻi ʻana o ka insulin i loko o ke koko - hyperinsulinemia.

ʻO ka Hyperinsulinemia me ke kaila koko maʻamau he hōʻailona ia o ka kū ʻana o ka insulin a me kahi harbinger o ka hoʻolālā ʻana i ka maʻi type 2. ʻO ka lōʻihi o nā manawa, ua pau nā cell beta o ka pancreas e hoʻohālikelike i ka ukana, he mau manawa he ʻoi aʻe ma mua o ka maʻamau. Hoʻopili lākou i ka emi a me ka liʻiliʻi o ka insulin, he nui ke kō me ke kō koko a me ka maʻi diabetes.

Hoʻopilikia ka pilikia Cardiovascular

Hōʻike nā haʻawina i ka pololei pololei ma waena o ka nui o ka insulin a me nā mea kūlohelohe no ka maʻi cardiovascular. Ke alakaʻi nei ka insulin i ka mea kūpono:

hoonui ae i ka hanu,
ua piʻo ke kaila kolamu a ke koko, a me nā pāpaʻi mai ka puka kino o ka "kino" ma luna o nā paia o nā kīʻaha koko,
nui ka loli o ke koko i nā moku,
lilo ka pā o ka ʻili o ka carotid maʻa (ʻo ka lumen o ka pā kani ka pili).

Ua hōʻike ʻia kēia pilina paʻa i loko o nā mea maʻi me ka diabetes type 2 a me nā mea ʻole me ke ʻole.

Kālo Hāpala 3

Nā mea waiwai:

½ Tbsp. Nā lau malo,
15 g o nā lau ʻukena,
35 g o nā lau walnut
35 g lau laupaʻa.

Hoʻohana:

Hoʻohui i kēia mau mea kanu, waiho no nā minuke he ʻumi a inu i ʻekolu mau manawa i ka lā.

ʻO ka lāʻau lapaʻau no ka paleʻana i ka insulin

Ke makemake nei ka lāʻau lapaʻau e hōʻemi i ke kō koko koko, a no laila, e kāpae i ka hyperinsulinemia.

ʻO nā lāʻau lapaʻau āu e hoʻohana ai he hypoglycemic oral ma waena āu i hiki ai ke hoʻomaopopo:

Biguanides: Aia ʻo Metformin i kēia kolamu, a kūpono kūpono i ka hihia o ka pale ʻana o ka insulin mai ka momona, me ka hoʻēmi ʻana hoʻi i ka manaʻo o ka pōloli.
Nā Hoʻopiha: nā lāʻau lapaʻau e hoʻohana ʻia ana e hoʻohaʻahaʻa i ke kōpaʻa koko ma hope o ka ʻai ʻana, i waena o mākou e kīleʻaleʻa i ka repaglinide.
Sulfonylurea: hoʻonui i ka ʻike o nā ʻoli i ka insulin, akā hiki ʻole ke hoʻohana mau ʻia, no ka mea hiki iā lākou ke hōʻoli i nā loli o ka protein o ka plasma. ʻO Glycvidone, glipizide a me glibenclamide e pili ana i kēia māhele.

Ua hoʻāʻo mākou e hana i kahi kiʻi maʻamau o ka pale ʻana o ka insulin. Maikaʻi loa kēia ʻano pili i nā hihia koʻikoʻi, no laila he mea nui ka pale ʻana.

Nā hōʻailona o ke kū'ē o ka insulin - nā kumu a me nā meaʻai therapeutic