Tulip 10

Ka puka helu - nā papa ʻoniʻoni kiʻi: 10 mg - keokeo a ʻulaʻula paha ke keʻokeʻo, HLA 10 ka kaha a pau i hoʻokahi ʻaoʻao, 20 mg kukui kīwīwīwīwīwī kukui, he kiʻi ukana HLA 20 ma kahi ʻaoʻao, 40 mg - keokeo keokeo me ke kaila poʻomanaʻo brownish brownish i hoʻokahi ʻaoʻao, "HLA 40" kahakaha, nā papa biconvex, ka pōʻai, ʻāpana - keokeo (10 mau p. i nā blisters, i loko o kahi pā o ka pahu 3, 6, 9 blisters).

Helu 1 papa:

• mea kūlohelohe: atorvastatin (ma ke ʻano o ka atorvastatin calcium) - 10, 20 a 40 mg,
• ʻO nā mea kōkua: nā sodium croscarmellose, lactose monohidate, polysorbate 80, hyprolose, colloidal silicon dioxide, magnesium stearate, kaumaha magnesium oxide, microcrystalline cellulose,
• pāpale kiʻi: hyprolose, hypromellose, macrogol 6000, talc, titanium dioxide, no kahi pāʻālua o 20 a 40 mg, aia kekahi, ʻeleʻele ka hao oxide.

Nā hōʻailona no ka hoʻohana ʻana

• ʻO ka hypercholesterolemia primel, ka heterozygous familial a non-familial hypercholesterolemia a me nā mea i hui pū ʻia (kāwili) ʻano IIa a me IIb hyperlipidemia e like me ka helu ʻana o Fredrickson - Tulip hoʻohana i hui pū me ka hypocholesterolemic diet e hōʻemi i nā mea i manaʻo ʻia o ka kolesterol (Chc), lipoprotein haʻahaʻa haʻahaʻa A (a) ʻO B (apoV), thyroglobulin (TG), a me ka hoʻonui ʻana i ke kaomi o ka lipoprotein kolamu kiʻekiʻe (HDL-C), i ka wā e mālama ai i ka lāʻauʻai a me nā ʻano lāʻau ʻole wale nō. liʻiliʻi ko lākou hopena
• ʻO ka homozygous familial hypercholesterolemia - e hōʻemi i nā kiʻekiʻe kiʻekiʻe o LDL-C a me ka kolamu holoʻokoʻa, i ka wā mālama wale ai i ka meaʻai a me nā ʻano lāʻau ʻē aʻe ʻaʻole i lawa ka maikaʻi.
• Nā maʻi hōʻemi a me nā maʻi maʻi me ka ʻole o ka hōʻailona o ka maʻi coronary heart disease (CHD), akā i ka hiki ʻana o kekahi mau wahi pilikia o kona hoʻomohala ʻana, e like me ka addotate ʻo nikotine, hypertension arterial, retinopathy, maʻi maʻi mellitus, albuminuria, nā hōʻemi plasma haʻahaʻa o HDL-C, genetic predisposition, a me ke kūpaʻa ʻana i ka hope o dyslipidemia, ʻoi aku ma mua o 55 makahiki - no ka pale mua ʻana.
• hoʻopiʻi cardiovascular ma nā mea maʻi me ka maʻi ʻalani coronary - prophylaxis kūmole o ke kūlana e hōʻemi i ka nui o ka make nui, stroke, myocardial infarction, hou-hospitalization no ka angina pectoris a me ka pono no ka revascularization.

Nā Hoʻohui

• hana ʻino i ka hana ikaika,
• ka hoʻonui ʻana i ka hana plasma o nā transaminases hepatic i ʻike ʻole ʻia ma ka hoʻohālikelike ʻana me ka palena palena kiʻekiʻe o ka maʻamau (VGN) ma mua o 3 mau manawa,
• glucose-galactose malabsorption syndrome, lactose intolerance, lactase nele (komo i ka lactose),
• ka hapai a me ka wā o ka umauma (lactation),
• nā keiki a me nā ʻōpio ma lalo o 18 mau makahiki (ʻo ka maikaʻi a me ka palekana o ka lawe ʻana i ka atorvastatin i kēia ʻōpio o nā mea maʻi ʻaʻole i hoʻokumu ʻia),
• hoʻonui ka naʻau pilikino i nā mea o ka lāʻau.

Me ka makaʻala, hoʻohana ʻia ʻo Tulip i ka hihia o ka palupalu electrolyte koʻikoʻi, ka mōʻaukala o nā maʻi o ka ate, ka hōʻino ʻona, ka maʻi ʻula a me ka mōʻaukala o nā mālamuhumu o ka hoʻowi ʻana ma muli o ka hoʻohana ʻana o nā lāʻau ʻē aʻe o ka hui o HMG-CoA reductase inhibitors, metabolic a me endocrine (hyperthyroidism ) nā maʻi huakaʻi, maʻi hypotension, diabetes mellitus, maʻi nui o ka maʻi ʻeha (sepsis), epilepsy i kaohi ʻole ʻia, ka hōʻeha nui, trauma, lipid kūloko ho'ēmi i ka maʻi (atorvastatin ma kahi o 80 mg) no ka pale ʻana i ka lua o ka maʻi ma nā mea maʻi me ka mōʻaukala o ka hemorrhagic a i ʻole lacunar.

ʻLoe a me ke kākele

Ma mua o ka hoʻomaka ʻana i ka hoʻohana ʻana i ka lāʻau Tulip, pono ke hoʻomanawanui e hāʻawi i ka ʻai maʻamau hypocholesterolemic, pono e nānā ʻia i ka wā holoʻokoʻa o ka mālama ʻana me ka lāʻau lapaʻau.

Lawe ʻia nā papa papaʻaina, me ka mea ʻole o ka meaʻai.

ʻO ka papa ʻōlelo pono o kēlā me kēia lā o Tulip he 1080 mg, ua koho ʻia kahi ʻano kikoʻī ma muli o ka neʻe ʻana o ka LDL-C, ke kumu o ka mālama ʻana a me ka pane o kēlā me kēia maʻi o ka mea maʻi.

ʻO ka lāʻau mua ma ka hapa nui he 10 mg i kēlā me kēia lā, ʻo ka lōʻihi - 80 mg i kēlā me kēia lā.

I ka hoʻomaka ʻana o ka hoʻōla, ma hope o nā lā 14-28 a i ʻole me kēlā me ke hoʻonui o ka nui o ka lāʻau lapaʻau, pono e ʻike ʻia ka ʻike ʻana o ka plasma a me ka mea inā pono, e pono ke hoʻoponopono ʻia ka nui o ka atorvastatin.

Wahi paipai:

• ʻO ka maʻamau (heterozygous hereditary and polygenic) hypercholesterolemia (type IIa) a me ka hyperlipidemia hui ʻia (type IIb): kahi pāʻauʻauʻauʻu o 10 mg hoʻokahi lā i ka lā maʻamau e lawa (10 a 20 mau papaʻu e hiki ke hoʻohana ʻia), inā pono, e hoʻomāhuahua i ka dosis i 80 mg (2 mau papa o 40 mg), e noʻonoʻo ana i ka pane a ka mea maʻi a nānā i ka wā ma waena o ka piʻi ʻana o ka dosis i nā lā 14-28, no ka mea, ua nānā ʻia ka hopena therapeutic ma hope o 14 mau lā, a ʻo ka nui ka hopena therapeutic i hoʻopaʻa ʻia ma hope o 28 mau lā a lōʻihi no ka l lōʻihi ke kea
• ʻO ka homozygous herdary hypercholesterolemia: 80 mg (2 mau papa o 40 mg) 1 mau lā i ka lā,
• maʻi maʻi cardiovascular (no ka prophylaxis): 10 mg hoʻokahi i ka lā, inā ʻaʻole i loaʻa ka pae kiʻekiʻe o ka plasma o ka LDL, e ʻae ʻia e hoʻonui pinepine i ka dosis i 80 mg (2 papa o 40 mg), i ka noʻonoʻo ʻana i ka pane a ka mea maʻi a nānā i ka wā ma waena o ka hoʻonui ʻana o ka nui o 14 –28 lā.

ʻAʻohe hoʻoponopono hoʻoponopono o Tulip e pono ai no nā poʻe maʻi me ka hiki ʻole o ka maʻi a me nā poʻe maʻi maʻi.

Me ka hana ole o ka puʻuwai maʻi, ka hemo ʻana o ka atorvastatin mai ke kino i ka hoʻohaʻahaʻa ʻia, no laila ke kuhikuhi ʻia e hoʻohana ʻana me ka akahele, kiaʻi mau i ka hana o nā transaminases hepatic: aspartate aminotransferase (ACT) a me alanine aminotransferase (ALT).

Nā hopena hopena

• Pūnaehana nerve: pinepine - ka ʻeha, ka pinepine - hoʻonaninani i ka hiamoe (e komo i ka insomnia a me nā hōʻea pōkepili), haunaele, asthenic syndrome, paresthesia, hypesthesia, nāwaliwali, hoʻoluhi nā mea hoʻomanaʻo / pio, hoʻoweliweli i ka hoʻoweliweli, ʻokoʻa - ka neuropathy peripheral.
• nā hui kuʻuna: pinepine - ʻike wuhi, tinnitus, luhi - ʻike maka ʻole, ʻike liʻiliʻi - lohe luhi,
• hoʻoweliweli ʻāwīwī: pinepine - flatulence, constipation, nausea, dyspepsia, ʻeha, hoʻonaninani - pinepine - helehelena, anorexia, hepatitis, pancreatitis, belching, ʻeha o ka ʻōpū, ʻokoʻa - cholestatic jaundice (komo obstruktive), ʻehā loa - paʻakikī ʻole.
• musculoskeletal system: pinepine - kaʻe o nā ʻanā, myalgia, arthralgia, ʻeha hoʻeha, ka puʻu ʻana o ka naʻau, ʻeha hoʻi, ʻeha - ʻeha i ka ʻāʻī ʻāʻī, myasthenia gravis, maʻu myositis, myopathy, rhabdomyolysis, tendinopathy (i kekahi manawa ma mua o tendon tenda) ka palena maʻamau - nā hihia o ka necrotizing myopathy paʻa hewa,
• ʻili a me ka ʻili o ka subutaneus: pinepine - ʻili o ka ʻili, ka ʻeha, ka urticaria, alopecia, i ʻole nā ​​manawa - ka pīhoihoi, angioedema, erythema multiforme (e pili ana i ka maʻi o Stevens-Johnson) a me Lyell syndrome (ke ʻano o ka necrolysis epicmal epidermal).
• hematopoietic ʻōnaehana: pinepine - thrombocytopenia,
• metabolism: pinepine - hyperglycemia, pinepine - hypoglycemia,
• ʻūnaehana hanu: pinepine - ʻehaʻeha, nasopharyngitis, nosebleeds,
• ka hiʻi kino: pinepine - kūlike o ke ʻano hypersensitivity, loa i ʻole - anaphylaxis,
• nā hōʻailona limahana: ka pinepine - hoʻonui i ka hana o ka serum creatine phosphokinase (CPK), hoʻonui i ke ʻano o ALT a me AST, pinepine - leukocyturia, ʻike kaohi ʻole - hoʻonui i ka neʻe o ka hemoglobin glycosylated.
• nā hopena ʻē aʻe: pinepine - hoʻonui i ka momona, ka nele o ka renal lua, ka maʻi kīnā ʻole, hyperthermia, edema peripheral, ʻeha ʻeha, ka loaʻa ʻana o ka momona, ʻokoʻa loa - ka maʻi diabetes mellitus, gynecomastia, aia kekahi mau hōʻike e pili ana i ka hoʻomohala ʻana i ka fasciitis kūlā, akā ʻo ka pili kūpono me ka hoʻohana ʻana o ka atorvastatin ʻaʻole ia. hoʻokumu, paʻa ole - maʻi maʻi interstitial (ʻoi aku me ka hoʻohana mau ʻana), ke kaumaha, hana kelepona.

I ka hihia o kahi overdose o Tulip, pono ke ʻano lāʻau maʻi. ʻAʻohe Atorvastatin i kahi antidote kiko, a ʻaʻole maikaʻi ka hemodialysis ma muli o ke kaha nui ʻana o ka lāʻau lapaʻau i nā protein plasma koko.

Nā ʻōlelo kikoʻī

ʻO Tulip, e like me nā statins ʻē aʻe (HMG-CoA reductase inhibitors), hiki ke hoʻonui i ka hana serum o nā enzymes ACT a me ka ALT e ʻoi aku ma mua o 3 mau manawa i ka hoʻohālikelike ʻia me VGN. No laila, pono e nānā i nā ʻōnaehana hana kāpili ma mua o ka lawe ʻana i ka lāʻau lapaʻau, ma hope o 6 a me 12 mau pule mai ka hoʻomaka ʻana o ka hoʻōla a me ke piʻi ʻana o kona maʻi. Pono pono ke nānā aku i nā ʻōkuhi hana pili pono i ka wā e puka ʻia ai nā hōʻailona lapaʻau o kāna lesion. Me ka hoʻonui ʻana o nā hana a ACT a me ALT, pono e nānā ʻia nā ʻōkuhi a hiki i nā kumu hoʻohālikelike, inā he ʻoi aku ka nui o ka manawa ma mua o 3 mau manawa ma mua o VGN a hoʻomau wale ia, e hōʻike ʻia e hoʻemi i ka pāheʻe a i ʻole oki i ka lawe ʻana i ka lāʻau.

Hiki i ka hoʻohana ʻana i ka lāʻau lapaʻa Tulip hiki i ka hoʻomohala ʻana i ka myalgia. I nā mea maʻi me ka maʻi myalgia, ʻeha palupalu a nā ʻeha a me / a i ʻole ka hoʻonui ʻana i ka hana CPK, hiki ke ʻōlelo ʻia ka myopathy. I kēia hihia (ʻo ka hele ʻana o ka mana a me ka manaʻo i hōʻoia ʻia no ka hoʻohuihui i hoʻopaʻa ʻia), pono e hoʻohiolo ʻia ka hopena atorvastatin.

Ma muli o ka hoʻonui nui o ka myopathy me ka hoʻohana pinepine ʻana i ka tulip me ka immunosuppressants, fibrates, azole antifungal drug, erythromycin, nicotinic acid (ma nā lipid-hoʻohaʻahaʻa i nā hapa heʻoi aku ma mua o 1 g i kēlā me kēia lā), ke hoʻomaka nei ka lāʻau lapaʻau ma hope wale nō o ka loiloi ʻana i ka pae o ka pōmaikaʻi e pili ana i ka hopena me ka hopena o ka hopena ʻeha. hoʻoiho. Inā pono, ʻōlelo ʻia ke ʻano hui e noʻonoʻo i ka hiki o ka hoʻoponopono ʻana i nā pakanui mua a me ka mālama ʻana i nā lāʻau i ke ala no ka hōʻemi ʻana.

I ka wā mālama, ʻo ka hana CPK a me ka uʻi o ka glucose serum e mālama pono ʻia.

Pono e ʻike ʻia nā mea maʻi e pili ana i ka pono e kūkākūkā koke i ke kauka inā inā loaʻa ka ʻeha a me / a i ʻole nāwaliwali o ka ikaika, e hele pū me ka maʻi mau a me ka maʻi maʻamau.

ʻO ka hihia o ka rhabdomyolysis me ka hoʻomohala ʻana o ka hana ʻole o ka pilikia kōpili ma muli o ka myoglobinuria ma muli o ka hoʻohana ʻana i ka lāʻau Tulip, a me nā stinins ʻē aʻe (HMG-CoA reductase inhibitors) i wehewehe.

Inā he mau hōʻailona o ka hiki aopopia a i ʻole ka hopena i ka hoʻomohala ʻana i nā ʻeha o ka renal (hypotension arterial, maʻi hōʻeha koʻikoʻi, trauma, hoʻoweliweli ākea, hōʻeha metabola, endocrine a me ka electrolyte, kuʻihue ʻole nā ​​mākaukau) aʻo ka lawe ʻana i ka rhabdomyolysis, pono e hoʻoki ʻia ka atorvastatin.

I ka wā o ka mālama ʻana me Tulip, pono ka mālama ʻana i ka wā e hoʻokele ana i nā kaʻa a komo i nā ʻano ʻē aʻe ʻē aʻe o ka hana, pono ai ke ʻano nui o ka mālama ʻana a me ka wikiwiki o ka hopena psychomotor.

Hoʻohui nūhou

• cyclosporine, erythromycin, clarithromycin, immunosuppressive, antifungal drug (azole derivatives): hoʻonui i ka pilikia o ka myopathy i ka wā like me ka HMG-CoA reductase inhibitors ma muli o ka hiki ke hoʻonui i ka paʻū serum o ka atorvastatin,
• indinavir, ritonavir (ʻO nā mea pale aku i ka protease), nā fibrates a me ka acid nikotinic (i nā lipid-hoʻohiolo ʻana i nā haʻahaʻa e ʻoi aku ma mua o 1 g i kēlā me kēia lā): hoʻonui i ka pilikia o ka hoʻomohala ʻana i ka myopathy,
• ka mea hoʻomehana o ka isoenzyme CYP3A4 (me ka hoʻohui pū ʻia o protease): hiki i ka nui ke komo ʻana o ka plasma i ka atorvastatin,
• OATP1B1 inhibitor protein protein inhibitors (e.g. cyclosporine): e hoʻonui i ka bioavailability o atorvastatin,
• erythromycin a me clarithromycin: hoʻonui i ka manaʻo o ka atorvastatin i loko o ke koko koko (e ka 40% a me 56%, ia manawa),
• diltiazem: ma kahi o 240 mg me 40 mg o ka atorvastatin e hoʻonui i ka kaila o ka poʻe i loko o ke kō koko plasma,
• cimetidine: ʻaʻole i ʻike ka pili pono o nā clinically me ka atorvastatin,
• itraconazole: ma kahi o ka 200 mg me ka 20-40 mg o ka atorvastatin, ke kumu nui o AUC o ka atorvastatin 3 mau manawa e hoʻonui ai,
• huehue o ka ʻona: i loko o ka nui o nā hapa he 1,2 lita i hoʻokahi lā no 5 mau lā hiki ke ulu i ka kaila o ka plasma o atorvastatin,
• inducers o CenP3A4 isoenzyme (no ka laʻana, efavirenz a i ʻole rifampicin): hiki ke alakaʻi i ka hoʻohaʻahaʻa ʻana i ka atorvastatin i loko o ke koko koko, no ka mea, he mea hoʻohana nui ʻia ka rifampicin e ka hui o ka isoenzyme CYP3A4 a i ka manawa like me ka pale o ka hepatocyte protein protein OATP1B1 i kēia manawa
• antacids: hui pū ʻia o ka hoʻopiʻi ʻana i nā suspensions e loaʻa ana i ka alumini a me nā konohiko magnesium me ka atorvastatin e hōʻemi i ka hoʻoliʻi plasma o ka hopena o ka hopena

35%, akā ke loli o ka pae o ka hōʻemi o ka LDL-C,

ʻO nā mea pono a Tulip nā: Anvistat, Atomax, Ator, Atorvastatin, Atoris, Atorvoks, Vazator, Lipoford, Liptonorm, Liprimar, Torvazin, Novostat, Torvalip, Torvakard, Torvas a me nā mea ʻē aʻe.

Pākuʻi helu

Nā papa hana ʻulaʻī.

1 papa pāahī-kiʻi e pili ana: mea waiwai: atorvastatin calcium 41.43 mg (ma nā ʻōlelo o ka atorvastatin 40.00 mg), nā mea hoʻowalewale: microcrystalline cellulose 284.97 mg, lactose monohalae 69.60 mg, sodium croscarmellose 38.40 mg, hyprolose 4.00 mg, polysorbate 80 5.20 mg, kaumaha magnesium oxide 52.00 mg, colloidal silicon dioxide 2.40 mg, 2.000 mg, ukana moku: hypromellose 5.952 mg, hyprolose 1.488 mg, titanium dioxide 2.736 mg, macrogol 6000 1,200 mg, talc 0,600 mg, iron oxide yellow E 172 0,024 mg.

ʻO keʻano

ʻO ke keʻokeʻo me kahi hāpana brownish-brownish, nā papa biconvex pōkā, uhi ʻia ke kiʻi ʻoniʻoni, me ke kahakaha ʻia me "HLA 40" ma kahi ʻaoʻao.
Kink maka: papa keʻokeʻo.

ʻO nā waiwai Pharmacological

Lapaʻau lāʻau
ʻO Atorvastatin kahi mea mālama i ka hoʻokūkū koho o HMG-CoA reductase enzyme e hoʻololi ana i ka 3-hydroxy-3-methylglutaryl coenzyme A i ka mevalonic acid, kahi mea i mua o ka sterols, e komo pū me ka kolamu.
Hoʻokomo ʻia ʻo Triglycerides (TG) a me ka cholesterol i ka hoʻohui ʻana o nā lipoproteins density haʻahaʻa loa (VLDL) i ka wā synthesis o ka ate, e komo i ke koko koko a lawe ʻia i nā kino peripheral. Kūkulu ʻia nā lipoproteins haʻahaʻa (LDL) mai VLDL i ka wā o ke kikowaena me nā LDL taliaina.
Ua hōʻike ʻia nā haʻawina ʻo ka hoʻonui ʻana i ka ʻike o ka kolesterol nui i ka plasma, LDL a me nā apolipoprotein B (ʻApolo-B) i kōkua i ka hoʻomohala ʻana o ka atherosclerosis a ʻo ia nō kekahi o nā mea pilikia no ka maʻi cardiovascular, ʻoiai e hoʻonui nei i ka kaʻe o ka lipoproteins density kiʻekiʻe (HDL) i hōʻemi i ka hopena ka hoʻomohala ʻana o nā maʻi cardiovascular.
Hoʻopili ke Atorvastatin i ka hoʻoneʻe ʻana o ka kolamu a me nā lipoproteins i ka plasma koko ma muli o ke kaohi ʻana o ka HMG-CoA reductase inhibitor, ke ʻano o ka cholesterol i loko o ka ate a me ka hoʻonui ʻana i ka nui o nā ʻalopona "LDL" ma ka ʻaoʻao o ka pūloli, kahi e hoʻonui ai i ka huki a me ka catabolism o LDL.
Hoʻopili ʻo Atorvastatin i ke kō a me ka ʻike o ka LDL kolamu, ka nui o ka kolamu, Apo-B i nā mea maʻi me ka hypercholesterolemia homozygous a me ka heterozygous, ka hypercholesterolemia mua a me ka hyperlipidemia hoʻopili.
E hana ana hoʻi i ka emi ʻana o ka hōʻemi o ka cholesterol-VLDL a me TG a me ka hoʻonui ʻana o ka piʻi ʻana o ka cholesterol-HDL a me ka apolipoprotein A (Apo-A).
I ka poʻe maʻi me ka dysbetalipoproteinemia, ke emi nei ka ʻike ʻana i nā lipoproteins o ke kūmau waena o ka cholesterol-LBP.
I ka hoʻokeoʻana o Atorvastatin i ka 40 mg e hoʻemi ana i ka hoʻoliʻiliʻi o ka kolamu o ka nui o ka 37%, LDL - e 50%, Apo-B - e ka 42% a ʻo TG - e ka 29%, ka mea i hoʻoili ai i ka piʻi ʻana o ka hololi HDL a me Apo-A.
Hoʻopau i ka dosis-hilinaʻi i ka hoʻoneʻeʻana o LDL i nā mea maʻi me ka hypercholesterolemia homozygous homozygous, kūpaʻa i ka maʻi maʻi me nā lipid-hoʻēmi haʻahaʻa.
ʻAʻohe o carcinogen a me nā hopena mutagenic.
Hoʻomohala ka hopena therapeutic i nā 2 mau pule ma hope o ka hoʻomaka ʻana o ka hoʻomaʻamaʻa, hiki i ka nui ma hope o 4 mau pule a kū i ka wā mālama.
Lapaʻau lāʻau
Hoʻopuka a hoʻoili. He kiʻekiʻe nā Absorption. ʻO ka pae kiʻekiʻe loa i ka plasma (Cmax) ma hope o ka hoʻokō ʻana o ka waha ma hope o 1 - 2 mau hola. ʻO Сmax i nā wahine he 20% kiʻekiʻe, ʻo ka wahi ma lalo o ka pihi o nā manawa paʻa (AUS) he 10% haʻahaʻa ma mua o nā kāne, ʻaʻohe ʻano o nā maʻi. ʻO Сmax i nā mea maʻi me ka cirrhosis ate alkohol (kahi papa B ma ke kiʻekiʻe Child-Pugh) he 16 mau manawa, a me AUS - 11 mau manawa kiʻekiʻe ma mua o ka maʻamau.
Hōʻemi iki ka ʻai ʻana i ka wikiwiki a me ka pae o ka inu ʻana i ka lāʻau (e 25% a me 9%, kēlā), akā, ʻo ka hoʻohaʻahaʻa ʻana i ka kolamu LDL e like like me ka atorvastatin me ka ʻole o ka ʻai kai.
Ma hope o ka hoʻoponopono waha ʻana i ka atorvastatin i ke ahiahi, ua hoʻohaʻahaʻa ka mālama plasma (Cmax a me AUC ma kahi o 30%) ma hope o ka hoʻokō ʻana i ke kakahiaka, akā naʻe, ʻaʻole ka hilinaʻi ka kaʻe o ka koleka LDL i ka manawa o ka lā e lawe ʻia ai ka lāʻau.
Ua hōʻike ʻia kahi pilina palena ma waena o ke kūkaʻi o ka huina a me ka loaʻa ʻana o ka lāʻau lapaʻau.
ʻO Bioavailability o 12%, system ole bioavailability o ka hana pale ma ke ʻano he HMG-CoA reductase ma kahi o 30%. ʻO ka bioavailability haʻahaʻa haʻahaʻa ma muli o ka presystemic metabolism ma o ka gastrointestinal tract (GIT) a i ka wā o ka "pae mua" ma o ke ake.
ʻO ka hapa nui o ka hoʻoilina he 381 l, ka pilina me nā kōmela plasma o 98%.
ʻO ka pāʻelele o ka atorvastatin i loko o nā kaila koko / kōmela koko ma kahi o 0.25, ʻo ia hoʻi, ʻaʻole i komo ka atorvastatin i loko o nā kōpela koko.
Metabolism a me ka hoʻopā ʻana. Ka hana nui ʻana o ka Atorvastatin i loko o ka puʻuwai ma ka hana o nā isoenzymes CYP3A4, CYP3A5 a me CYP3A7 me ka hoʻokumu ʻana i nā metabolites hoʻolaʻa pharmacologically (ortho- a me para-hydroxylated derivatives, nā hua beta-oxidation). In vitro Nā ortho- a me nā pālahalohilohi parahydroxylated he hopena ʻokoʻa ma ka HMG-CoA reductase, i hoʻohālikelike ʻia i ka atorvastatin. ʻO ka hopena o ka hopena o ka lāʻau e kūʻē i ka HMG-CoA reductase ma kahi o 70% e hoʻoholo ana e ka hana o nā metabolites kaʻai ʻana, ka mea e hoʻomanaka nei ma kahi o 20 a 30 mau hola, ma mua o ko lākou heleʻana.
Nā hopena noiʻi i loko o vitro manaʻo e hoʻokūkū ka CYP3A4 isoenzyme i ka hana nui o ka metabolism o ka atorvastatin. Hoʻomaopopo ʻia kēia ma ka hoʻonui ʻana o ka pehu o ka atorvastatin i loko o ke kaila koko aʻo ka lawe ʻana i ka erythromycin, ʻo ia hoʻi ka mea hoʻohui o kēia isoenzyme.
Ke noiʻi i loko o vitro ua hōʻike pū ʻia kekahi o ka atorvastatin kahi nāwaliwali ikaika o ka isoenzyme CYP3A4.
Hoʻokuʻu ʻia ia ma o ka ʻōpū ma hope o ka maʻi hepatic a me / a i ʻole ka nui o nā hoʻokūkū extrahepatic (ʻaʻole i loaʻa ka lāʻau lapaʻau i ka haʻi ʻana i ka enterohepatic hai). ʻO ka hapalua ola (T1 / 2) he 14 mau hola. ʻOi ka liʻiliʻi o 2% o kahi kūpono i loko o ka waiʻai.
ʻAʻole ia i hoʻōla ʻia i ka wā o hemodialysis ma muli o ka hoʻopili koʻikoʻi i nā protein plasma.
ʻO Cmax lāua ʻo AUC o ka lāʻau lapaʻau i nā mea maʻi ma waena oʻelemakule (70 mau makahiki a ʻoi aku) he 40 a 30%, ʻoi aku ka nui, i ke kiʻekiʻe o nā maʻi ʻōpio, akā ʻaʻole naʻe kēia mau kumu lapaʻau.
Hoʻopilikia i ka hana renal papaha ke hoʻopilikia i ka paʻa o ka lāʻau i loko o ke koko koko.

Hoʻohana i ka wā hāpai a i ka wā o ka umauma

ʻO ka lāʻau Tulip ® ka maʻi i ka wā hāpai.
No ka mea he mea nui ka kolamu a me nā mea i hoʻohuihui ʻia mai ka cholesterol he nui i ka hoʻomohala ʻana i ka maʻi hānai, ʻoi paha ka hopena o ka hōʻemi ʻana i ka HMG-CoA reductase i mua o nā pono o ka hoʻohana ʻana i ka lāʻau i ka wā hāpai.
Inā hoʻoholo ʻia ka hapai i ka wā o ka mālama ʻana me Tulip ®, pono e hoʻokaʻawale ke keʻena nei i ka hiki, a e haʻi ʻia ka mea maʻi i ka hopena o ka maʻi e hoʻopili ai ka wahine.
Hiki ke hoʻohana ʻia ka lāʻau lapaʻau Tulip ® i loko o nā wāhine o ka wā o ka hānau ʻana inā he haʻahaʻa loa paha ka hiki ʻana o ka hapai, a ʻike ʻia ka mea maʻi e pili ana i ka hiki ke hoʻopili i ka wahine ma ka wā mālama.
Pono nā wahine o nā makahiki hānau hānau i nā hana kūpono o ka contraception i ka wā mālama me Tulip ®.
Hoʻopili ʻia ka Atorvastatin i ka waiū umauma, no laila ua contraindicated no ka hoʻohana ʻana i ka wā o ka hoʻoulu ʻana, inā pono ia e hoʻohana i ka lāʻau Tulip ® i ka wā lactation, ʻōpiopio ka hopena.

ʻLoe a me ke kākele

Ma mua o ka hoʻohana ʻana i ka lāʻau lapaʻau Tulip ®, pono e ʻōlelo aku ka mea maʻi i kahi meaʻai hypocholesterolemae maʻamau, pono e hoʻomau ʻo ia e hahai ma loko o ka manawa mālama.
Manaʻo ʻia e hoʻohana i ka lāʻau lapaʻau Tulip ® i loko o kahi ʻole o ka manawa ʻai.
Ka hoʻohālikelike ʻia o ke ʻano o Tulip ® mai ka 10 mg a 80 mg i kēlā me kēia lā, a ke koho ʻia nei i ka noʻonoʻo pono o ka neʻe mua o ka kolamu LDL, ke kumu o ka hoʻouka ʻana a me kahi pane pilikino i ka hopena o ka maʻi.
No ka hapanui o nā maʻi, ʻo ka maʻa mua mua he 10 mg hoʻokahi i ka lā (hiki i ka hoʻohana ʻana i ka lāʻau atorvastatin ma ke ʻano hoʻohālikelike: nā papa o 10 a me 20 mg).
I ka hoʻomaka ʻana o ka hoʻōla a me / a i ka manawa o ka hoʻonui ʻana i ka maʻa o Tulip ®, pono ia e nānā i ka ʻike ʻana o nā lipids i ka plasma koko i kēlā me kēia 2 i ka 4 mau pule a hoʻoponopono i ka hopena o ka lāʻau lapaʻau ma muli.
ʻO ka palena kiʻekiʻe loa o kēlā me kēia lā he 80 mg / lā.
Hōʻike (heterozygous hereditary a polygenic) hypercholesterolemia (type IIa) a hui pū ʻia ka hyperlipidemia (type IIb)
ʻO ka inumua mua o 10 mg o ka lāʻau Tulip ® 1 mau manawa i kēlā me kēia lā (hiki nō ke hoʻohana i ka lāʻau atorvastatin ma ke ʻano hana papa: nā papa o 10 a me 20 mg). Inā kūpono, ke hōʻemi nui nei i ka pāʻai a hiki i 80 mg (2 papa o 40 mg) hiki, i ke ʻano o ka mea maʻi me ka huakaʻi o 2 a 4 wiki, ʻoiai ka hopena therapeutic e nānā ma hope o 2 mau pule, a me ka hopena therapeutic loa ma hope o 4 hebedoma. Me ka lōʻihi o ka mālama ʻana, hoʻomau kēia hopena. Homozygous hoʻoilina hypercholesterolemia
ʻO ka lāʻau Tulip ® ka nui o nā maʻi heʻe i loko o kahi mahele o 80 mg (2 papa o 40 mg) hoʻokahi i ka lā.
ʻAʻole koi ʻia ka hoʻoponopono ʻana o ka lāʻau o Tulip ® i nā mea maʻi me nā hana lōkuhi a me nā mea maʻi.
Kāohi pilikia Cardiovascular
Hoʻohana ʻia ʻo Tulip ® i loko o kahi pulu o 10 mg hoʻokahi i ka lā. Inā ʻaʻole i hoʻokō ʻia ka pae LDL kūpono loa, hiki ke hoʻonui i ka pakanō o ka lāʻau i ka 80 mg i kēlā me kēia lā, e pili ana i ka hopena o ka mea maʻi me ka huina o 2 a 4 mau pule.
I ka poʻe maʻi me ka hana o ka puʻuwai maʻi, ua lohi ka paʻahaʻi o ka atorvastatin mai ke kino, no laila ke noi ʻia nei e hoʻohana me ka mālama me ka nānā ʻana i nā hana o ka melamin "atam": aspartate aminotransferase (AST) a me alanine aminotransferase (ALT). Inā ke piʻi nei ka nānā i ka hana o AST a i ʻole ALT e ʻoi aku ma mua o 3 mau manawa i hoʻohālikelike ʻia me ka palena palena kiʻekiʻe o ka maʻamau (VGN), e kuhikuhi ʻia e hōʻemi i ka pākēpē a kāpae paha i ka lāʻau lapaʻau Tulip ®.

Loaʻa ka hopena

Wahi a ka World Health Organization (WHO), ua hōʻiliʻili ʻia nā hopena i makemake ʻole ʻia e like me ka nui o ka hoʻolālā ʻana e like me kēia: pinepine (> 1/100, 1/1000, 1/10000, mai ka pānaʻi huna.
pinepine: nā hopena kūlohelohe
loa loa: anaphylaxis.
Mai ka kikowaena waena a me ke kaʻaila peripheral
pinepine: lie kanikela
nuliuliu: hōʻeha, hoʻomāhaʻeha ka hiamoe, e komo pū me ka moeʻuhane a me ka pō "night Night", asthenic syndrome, nāwaliwali, paresthesia, hypesthesia, ʻoluʻolu ka hoʻonaninani, ʻalo ʻole a hōʻemi paha i ka hoʻomanaʻo,
jarang: maʻi pālahalaha peripheral.
Mai ka huehue wai ʻana
pinepine: constipation, flatulence, dyspepsia, ʻōpū, ʻeha, ʻeha,
nuliuliu: anorexia, luaʻi, pancreatitis, hepatitis, ʻeha ʻōpū, pale,
jarang: jaundice cholestatic (komo pū pū kekahi),
loa loa: pūpū hema.
Mai ka ʻōnaehana musculoskeletal a me nā ʻaoʻao pili
pinepine: myalgia, arthralgia, "ʻōpū" o nā ʻeha, ka ʻōpū o ke kuʻikuʻi, nā ʻeha o hope, nā ʻōpū o ka hoʻoikaika,
nuliuliu: nā ʻōpū o ke ʻāʻī, nā nāwaliwali o ke kino,
jarang: myopathy, myositis, rhabdomyolysis, tendinopathy (i kekahi manawa i paʻakikī i ka tendonure tendon)
ʻaʻole maopopo: ka hoʻopili ʻana i ka maʻi myopathy paʻa ʻole.
Mai nā naʻau kuikawa
nuliuliu: tinnitus, hemo blurr,
jarang: ʻike maka
loa loa: lohe pio.
Ma ka ʻāpana o ka ʻili a me nā momona subcutaneous
nuliuliu: urticaria, ʻāwīwī a me ke ʻano, alopecia,
jarang: angioedema, bullous rash, polymorphic exudative erythema (me ka hoʻohui ʻia o Stevens-Johnson syndrome), nāʻino o ka epidmal necrolysis (Lyell syndrome).
Mai ka ʻaoʻao o ka metabolism
pinepine: pālahalaha maʻi
nuliuliu: hypoglycemia, loaʻa ka paona.
Mai nā heʻano hemopoietic
nuliuliu: thrombocytopenia.
Mai ka papa huhū
pinepine: nasopharyngitis, ʻeha ka ʻōpū, nosebleeds.
Nā hōʻailona hana hana
pinepine: hoʻonui hana o ka serum creatinine phosphokinase (CPK), hoʻonui hana o ka "ate" transaminases,
nuliuliu: leukocyturia,
ʻaʻole maopopo: hoʻonui mahuahua o ka hemoglobin glycosylated.
Nā ʻili:
nuliuliu: luhi, luhi nā pōpilikia, hōʻōlohelohe renal lua, maʻi, ʻeha ʻeha, edema peripheral,
loa loa: gynecomastia, maʻi mellitus maʻi. Aia nā hōʻike kūʻokoʻa e pili ana i ka hoʻomohala ʻana i ka fasciitis ducic (kahi pilina me ka hoʻohana ʻana o ka atorvastatin ʻaʻole i hoʻokumu mua ʻia).
ʻaʻole maopopo: i ke kaumaha, maʻi interstitial maʻi (ʻoi aku me ka lōʻihi o ke kau ʻana), hana i ka moekolohe.

Ke keu

ʻAʻohe mea antidote kikoʻai no ka mālama ʻana i ka overdose.
I kahi hihia o ka overdose, pono e mālama ʻia ka hōʻailona maʻi.
Hemodialysis hiki ʻole (no ka mea ke hoʻopili nui nei ka lāʻau i nā protein plasma).

Hoʻopili pū me nā lāʻau ʻē aʻe

ʻO ka pilikia o ka myopathy i ka wā mālama me ka HMG-CoA reductase inhibitors e hoʻonui me ka hoʻohana pū ʻana o ka Cyclosporine, erythromycin, clarithromycin, immunosuppressive, antifungal drug (azole derivatives) ma muli o ka hiki i ka piʻi o ka neʻe o ka atorvastatin i ka serum koko.
Me ka hoʻohana pū ʻana me ʻO ka pale ʻana i ka protease HIV - indinavir, ritonavir - Ke hoʻonui nei ka pilikia o ka hoʻomohala ʻana i ka myopathy.
Hiki i kahi pilina like me ka hoʻohana pinepine ʻana i ka atorvastatin me nā lūlū me ka waikawa ʻo nikotinic i nā lipid e haʻahaʻa ana i nā wai (ʻoi aku ma mua o 1 g / lā).
Nā Hoʻolike CYP3A4 Isoenzyme
No ka mea ka hoʻāliele ʻana o atorvastatin me ka hoʻohana ʻana i ka Caveenzyme CYP3A4, ka hoʻohana pū ʻana o ka lāʻau Tulip ® me nā mea paʻa o kēia isoenzyme hiki ke alakaʻi i ka hoʻonui ʻana o ka atorvastatin i loko o ke kaila koko. ʻO ka pae nui o ka pilina a me ka hopena o ka hoʻonui ʻana i ka neʻe o ka atorvastatin e hoʻoholo ʻia e ka loli o ka hopena i ka isoenzyme CYP3A4.
OATP1B1 inhibitors protein protein
ʻO Atorvastatin a me kāna metabolites nā substrates o ka protein protein OATP1B1.
ʻOi ka papa o OATP1B1 (e.g., cyclosporine) e hoʻonui i ka bioavailability o atorvastatin. No laila, ʻo ka hoʻohana ʻana o ka atorvastatin ma kahi o ka 10 mg a me ka cyclosporine ma kahi maʻa o 5.2 mg / kg / lā e alakaʻi ana i ka hoʻonui ʻana o ka hoʻoliʻiliʻi o ka atorvastatin i loko o ke koko koko e 7,7 mau manawa.
Erythromycin / clarithromycin
Me ka hoʻohana pinepine ʻana o ka atorvastatin 10 mg a me ka erythromycin (500 mg 4 mau manawa i kahi lā) a i ʻole clarithromycin (500 mg 2 mau manawa i kahi lā), ka mea e hoʻokaʻawale i ka isoenzyme o ka cytochrome CYP3A4, ke piʻi nui ka piʻi ʻana o ka atorvastatin i loko o ke koko koko (e ka 40% i ka wā e hoʻohana pū ai me ka erythromycin a me 56% - i ka wā i hoʻohana ai me ka clarithromycin).
Nā mea hoʻomaloka piha
ʻO ka hoʻohana like ʻana o ka atorvastatin me nā protease inhibitors i ʻike ʻia ka inhibitors o ka isoenzyme cytochrome CYP3A4 i hui pū ʻia me ka piʻi ʻana o ka neʻe o ka atorvastatin i loko o ke koko koko (me ka hoʻohana like pū me ka erythromycin, Cmax o atorvastatin e hoʻonui ʻia e 40%).
Diltiazem
Ka hui pū ʻana o ka atorvastatin ma ke ʻano o 40 mg me ka diltiazem ma ke ʻano o 240 mg e alakaʻi i ka hoʻonui ʻana o ka atorvastatin i loko o ke koko koko.
ʻO Cimetidine
ʻAʻole i ʻike pū ʻia kekahi hopena olakino koʻikoʻi o ka atorvastatin me cimetidine.
Itraconazole
ʻO ka hoʻohana like ʻana o ka atorvastatin i nā wai mai 20 mg i 40 mg a me itraconazole ma kahi wai o 200 mg e alakaʻi i ka hoʻonuiʻana o 3-pi i ka AUC o atorvastatin.
ʻO ka wai huaʻai
No ka mea ke kahe o ka hua kōpona i kahi a i ʻole nā ​​mea e hoʻoneʻe ana i ka isoenzyme CYP3A4, ʻoi ka nui o kona hoʻohana (ʻoi aku ka 1,2 lita no ka lā no 5 mau lā) e hiki ai i ka hoʻonui ʻana i ka hoʻokomo o plasma i ka atorvastatin.
Hoʻokomo ʻia CYP3A4 Isoenzyme Inductors
ʻO ka hoʻohana pū ʻana o ka atorvastatin me nā inducers o ka isoenzyme CYP3A4 (no ka laʻana, efavirenz a i ʻole rifampicin) hiki ke alakaʻi i ka hoʻoilo ʻana o ka atorvastatin i loko o ka pulu koko. Ma muli o ka pālua o ka pilina me ka rifampicin (kahi inducer o ka isoenzyme CYP3A4 a me kahi mea hoʻomalu i ka hoʻokahe o ka heatocyte OATP1B1), ka hoʻohana pinepine ʻana o ka atorvastatin a me nā rifampicin ʻaʻole i ʻōlelo ʻia, no ka mea ua hoʻolōʻihi ʻia ka hoʻokele ʻana o ka atorvastatin ma hope o ke rifampicin e alakaʻi i ka wai nui o ka pehu o ka atorvast.
Hoʻokomo ʻia
Me ka hana like o ka atorvastatin a me kahi kōpena i loaʻa i nā konohiko a me nā hydroxides alumini i loko, ke emi nei ka ʻike ʻana i ka atorvastatin i ka plasma e pili ana i ka 35%, akā naʻe, ʻaʻole i loli ka nui o ke kahe o ka hōʻemi o ka cholesterol LDL.
Phenazone
ʻAʻole pili ʻo Atorvastatin i ka pharmacokinetics o phenazone, no laila, ʻaʻole i manaʻo ʻia ka launa pū me nā lāʻau ʻē aʻe e like me ka isoenzymes.
Colestipol
ʻOi aku ka hopena o ka lipid-hoʻohaʻahaʻa i ka hui me ka colestipol no kēlā me kēia pālolo i kahi kaʻawale, ʻoiai kahi 25% hōʻemi i ka neʻe o ka atorvastatin i ka wa i hoʻohana pinepine ʻia me colestipol.
ʻO ka waiona Fusidic
ʻAʻole i hana ʻia nā haʻawina e pili ana i ka hoʻopili ʻana o ka atorvastatin a me ka waikawa fusidic. E like me nā statins ʻē aʻe, ua hoʻopaʻa ʻia nā haʻawina hope ma ke ʻano o ka hoʻohana ʻana i ka atorvastatin a me ka waikawa fusidic i hōʻike ʻia i nā hopena hopena i ka ʻāʻī o ka pūpū, me ka rhabdomyolysis. ʻAʻole maopopo ka mīkini o ka pilina. Kūpono nā mea maʻi e nānā pono a me ka, hiki paha ke hoʻopau wale i ka wā o ka atorvastatin.
Kolosa
ʻOiai ʻaʻole i mālama ʻia nā haʻawina o ka pilina o ka atorvastatin a me colchicine, ua hōʻike ʻia nā hihia o myopathy i ka wā i hoʻohana pū ʻia ai me colchicine, a pono e mālama ʻia me ka mālama ʻana i ka atorvastatin a me ka colchicine.
Digoxin
Me ka hoʻohana hou ʻana o ka digoxin a me atorvastatin ma kahi maʻa o 10 mg, ʻaʻole i loli ka pāʻina kūloko o ka digoxin i loko o ke koko koko. Eia naʻe, ke hoʻohana nei i ka digoxin i hui pū me ka atorvastatin ma kahi maʻa o 80 mg / lā. hoʻonui ke kukuna o ka digoxin i ka plasma koko e piʻi ai ma kahi o 20%. ʻO nā mea maʻi e lawe ana i ka digoxin i hui pū me ka atorvastatin e koi ana i ka nānā ʻana o ka neʻe o ka digoxin i loko o ka kaila koko.
ʻO Azithromycin
Me ka hoʻohana ʻana o ka atorvastatin ma kahi o ka 10 mg 1 manawa / lā / lā a me azithromycin ma ke ʻano o 500 mg 1 manawa / lā, ka loli ʻana o ka atorvastatin i loko o ke kaila koko ʻaʻole i loli.
Nā maʻi hoʻohālikelike
Me ka hana like o ka atorvastatin a me ka ulu o ka waha e loaʻa ana i ka norethisterone a me ka ethinyl estradiol, he nui piʻi ka nui o ka AUC o norethisterone a me ka ethinyl estradiol ma kahi o 30% a 20%, ma kēlā me kēia, pono e noʻonoʻo pono i ke koho ʻana i kahi contraceptive ā waha.
Terfenadine
Hoʻohana ʻole ʻo Atorvastatin me ka hoʻohana ʻana i ka terfenadine i ka hopena koʻikoʻi nui i ka pharmacokinetics o terfenadine.
Warfarin
I ka poʻe maʻi e lawe warfarin i ka manawa lōʻihi, atorvastatin ma ke ʻano o ka 80 mg i kēlā me kēia lā e hoʻokaʻawale i ke manawa prothrombin i nā lā mua o ka ʻimi ʻana. E nalo aku kēia hopena ma hope o 15 mau lā o ka hoʻohana like ʻana o kēia mau lāʻau. ʻOiai nā hōʻike koʻikoʻi o nā loli he nui i ka hopena anticoagulant ua hōʻike pinepine ʻole ʻia, ʻike ʻia ka manawa prothrombin i nā mea maʻi e lawe ana i ka antrianagulants Coumarin i mua a ʻike pinepine ʻia i ka hoʻomaka ʻana o ka mālama ʻana me ka atorvastatin e hōʻoiaʻiʻo ʻaʻole ʻaʻohe loli koʻikoʻi i ka manawa prothrombin. Ke hoʻopaʻa ʻia nei ka manawa prothrombin paʻa, hiki ke nānā iā ia ma nā kikowaena maʻamau i nā poʻe maʻi e lawe ana i ka antmaragulants Coumarin. Inā hoʻololi ʻoe i ka ʻohi a kāpae paha i ka mālama ʻana, pono e hoʻihoʻi ʻia kēia mau ana. ʻAʻohe hui ma waena o ka hoʻohana ʻana i ka atorvastatin a me ke kahe a i nā hoʻololi i nā manawa prothrombin i nā mea maʻi ʻaʻole e lawe i nā anticoagulants.
Amlodipine
Me ka hana like o ka atorvastatin ma kahi maʻa o 80 mg a me amlodipine ma kahi maʻa o 10 mg, ʻaʻole i loli ka lāʻau lapaʻau ʻo ka atorvastatin i ka waiwai.
ʻO nā lāʻau lapaʻau e pili ana i ka lipid
Me ka hoʻohana like ʻana o ka atorvastatin me nā lāʻau hypolipidemic ʻē aʻe (no ka laʻana, ezetimibe, gemfibrozil, kahi huaʻai o ka fibroic acid) i ka hoʻohaʻahaʻa ʻana i ka wai, ʻoi ka hopena o ka hoʻonui ʻana i ka rhabdomyolysis e hoʻonui.
Hoʻololi hou
Me ka hoʻohana pū ʻana o ka atorvastatin me nā lāʻau antihypertensive a me nā estrogens (ma ke ʻano he kau hou), ʻaʻole i ʻike ʻia ka pili naʻau nui.

Ke hana lāʻau lapaʻau o Tulip

E like me nā kauoha no Tulip, ʻo ka mea kūpono no ka lāʻau ke atorvastatin. ʻO nā mea i hoʻopiʻi ʻia i nā papa nā magnesium stearate, colloidal silicon dioxide, magnesium oxide, sodium croscarmellose, polysorbate 80, hydroxypropyl cellulose, lactose monohydrate, microcrystalline cellulose.

ʻO Tulip kahi mea hoʻokūkū koho koho HMG-CoA reductase a me kahi enzyme e pili ana i ka hoʻololi o ka 3-hydroxy-3-methylglutaryl coenzyme A i ka mevalonate, ʻo ia ka mea i hana mua i nā steroid.

Kuhi ka hopena o ka lāʻau i ka hōʻemi nui ʻana:

• ke kānana a me ka ʻikepili o ka kolamu holoʻokoʻa,
• ka nui a me ke kō o nā palapona LDL i ke koko,
• level o TG a me ʻApolipoprotein B,
• hiki i ka uluʻana o nā hoʻopiʻi i nā maʻi cardiovascular.

Hāʻawi ʻo Tulip i ka maʻamau o ka pae o nā pae HDL a me nā apolipoprotein A.

ʻO nā lāʻau lapaʻa e hōʻemi ana i nā pae o ka LDL i ka poʻe me ka hypercholesterolemia homozygous i hua ʻole i kū i nā lāʻau lipid-haʻahaʻa.

I ka wā e lawelawe ʻia ai, mālama maikaʻi ʻo ia iā Tulip. Loaʻa ka ʻike kiʻekiʻe i ka plasma ma hope o 2 mau hola. He haʻahaʻa bioavailability haʻahaʻa a pili pono i nā protein koko. Hoʻomiliʻia ia i ka puʻuwai me ka hoʻolālā o kekahi mau metabolites ikaika i hiki i ka lāʻau. ʻO ka manawa hoʻopau o ka hoʻopauʻana i ka lāʻau mai ke kino he 28 mau hola. Ke hoʻohemo ʻia nei ma o nā ʻōpū.

Hoʻoponopono a me ke kālai ʻana o ka tulip

Ma mua o ka hoʻomaka ʻana i ka maʻi, pono e hoʻoneʻe ʻia ka mea maʻi i kahi meaʻai me ka kolamu haʻahaʻa. Kūpono ʻia ʻo Tulip i ka manawa 1 i ka lā, no ka ʻai ʻana o ka meaʻai.

Koho ʻia ka nui o ka lāʻau e ke kanaka e komo ana i ke kauka no kēlā me kēia maʻi, e pili ana i ke kumu o ka mālama ʻana a me ka pae o LDL-C. Ma ke kānāwai, ʻano ka palena o Tulip mai 10 a 80 mg. Hoʻopili ʻia ka hoʻoponopono ʻia ʻana o ka dosis 1 i ka manawa i 4 mau pule.

Lapaʻau lāʻau

He kiʻekiʻe ka pau ʻana o nā lāʻau lapaʻau. Hiki ke hoʻomaopopo ʻia ka ʻike kiʻekiʻe loa i ka plasma koko i nā hola 1-2 ma hope o ka lawe ʻana i ka lāʻau lapaʻau. Inā ʻoe e hoʻohana i ka lāʻau lapaʻau i ke ahiahi, e hoʻemi ʻia kona hoʻokahe ʻana i ke koko me ka mea e hōʻike ʻia ana i ka plasma koko ma hope o ka hoʻokō ʻana i ke kakahiaka.

Bioavailable ma 12-14%. Ma waena o nā kava, ʻoi aku ka liʻiliʻi ma 2% o ka lāʻau i hoʻopaʻa ʻia i loko o ka urine.

Me ka mālama pono

I kekahi mau hihia, pono e mālama ʻia ka hana. ʻO kēia ke ʻano o nā kūlana i kēia manawa.

• ka nānāʻoleʻole o electrolyte,
• maʻi maʻi ʻōnaehana
• maʻi mellitus maʻiʻi
• nā hopena endocrine a me nā metabolic,
• epilepsy
• haehae
• sepsis
• ka moolelo o na ha hemorrhagic.

Hoʻohana ʻia ʻo Tulip me ka akahele ma ka epilepsy.
Ua kauoha ʻia ka lāʻau me ka mālama ʻana i ka maʻi diabetes.
Ua kau ʻia ka lāʻau lapaʻau me ka mālama ʻana i nā poʻe maʻi e loaʻa nei i ka mōʻaukala o ka hemorrhagic stroke.

Pehea e lawe ai i ka tulip?

Ma mua o ka hoʻomaka ʻana i nā ʻano maʻi, pono e hāʻawi i ka ʻōlelo ʻana i ka mea maʻi e pili ana i ka hoʻomaʻamaʻa ʻana i kahi meaʻai e hiki ai ke hoʻohaʻahaʻa i ka cholesterol koko. Pono kēlā me kēia maʻi e aʻo i nā ʻōkuhi no ka hoʻohana.

He aha ka wae e koho ʻia ai ka pili ʻana o ka cholesterol i ke koko, ka makahiki o ka mea maʻi a pehea hoʻi i haʻalele ʻole ʻia ai ke ʻano o ka maʻi.

Pono ʻoe e lawe i nā papa i loko, ʻaʻole pili ka ʻai i ko lākou maikaʻi o ke kō.

Hiki i nā dosis ma 10 a 80 mg i ka lā. ʻO ka maʻa mua he 10 mg. Ma hope o 2 mau hebedoma o ka lapaʻau, nānā ke kauka i ke kiko o nā lipids i ke koko o ka mea maʻi. Hana ʻia kēia i mea e hoʻoholo ai i ka loli hoʻololi.

Pono ʻoe e lawe i nā papa i loko, ʻaʻole pili ka ʻai i ko lākou maikaʻi o ke kō.

I mea e pale ai i ka loaʻa ʻana o nā maʻi cardiovascular, ke hoʻohana nei kahi nui o 10 mg i kēlā me kēia lā. Ma ka mālamaʻana i ka hypercholesterolemia herozygous hereditary, hōʻike ʻia ia e lawe i ʻelua papa o 40 mg pākahi i kēlā me kēia lā, i.e. he ʻano kēia o 80 mg.

ʻŌpala Gastrointestinal

ʻO nā maʻi maʻamau ka maʻi nalo, ka luaʻi a me ke ahulau, flatulence a me ka constipation. ʻO nā hōʻailona hou aku ka loiloi e holo mai ana, pancreatitis, belching a me ka ʻeha i loko o ka ʻōpū.

ʻO nā hōʻailona pinepine ma hope o ka lawe ʻana i nā papa i manaʻo ʻia he nausea, luaʻi.
Ke hoʻohana nei i ka lāʻau lapaʻau, hiki iā ʻoe ke hoʻokokoke me nā hōʻino like ʻole e like me ka ʻeha i loko o ka ʻōpū.
ʻO ka hōʻike maʻamau maʻamau ma hope o ka hoʻohana ʻana i nā papa he pono e noʻonoʻo i ke poʻo.

Mai ka papa huhū

ʻOi paha ka hoʻomohala ʻana o ka nasopharyngitis, ke ʻano o ke kahe mai ka ihu a me ka ʻeha ma ke ʻāʻī.

Eia kekahi, ʻeha paha ka mea maʻi ma ka hemorrhage maka a me ka ʻike maka ʻana.
Mai ka pūnaehana hanu, hiki i ke kahe koko mai ka ihu.
Ma hope o ka hoʻohana ʻana i ka lāʻau lapaʻau, hiki i ka mea maʻi ke hōʻeha i ka urticaria a me ka wikiwiki.

Hoʻolaha ka waipuna

Mai inu i ka waiʻona i ka wā e mālama ai me ka lāʻau lapaʻau.

ʻAʻole hiki ke mālama ʻia nā lāʻau lapaʻau i ka wā o ka hōʻeha.
Mai inu i ka waiʻona i ka wā e mālama ai me ka lāʻau lapaʻau.
I ka wā o ka mālama ʻana me ka lāʻau lapaʻau, pono e hoʻomaʻamaʻa ʻia ka wā e hoʻokele ana i ke kaʻa.
ʻO ka hele ʻana o ka waiwai ikaika i ka waiū umauma, ʻaʻole pono ʻoe e hānai i kahi keiki i ka wā o ka mālama ʻana.

Hoʻohana i ka wā hāpai a me ka lactation

ʻAʻole hiki ke mālama ʻia nā lāʻau lapaʻau i ka wā o ka hōʻeha. Inā lilo ka wahine i ka manawa o ka mālama ʻana, pono ia e hoʻomaopopo i ke kauka e pili ana i kēia me ka hiki ke hoʻomau i ka mālama ʻana i ka lāʻau. ʻO ka hele ʻana o ka waiwai ikaika i ka waiū umauma, ʻaʻole pono ʻoe e hānai i kahi keiki i ka wā o ka mālama ʻana.

Hoʻohana i ka wā kahiko

ʻAʻole pono ia ko ke hoʻoponopono ʻana i ka lāʻau i ʻōlelo ʻia ʻia.

ʻOiai ʻo ka maikaʻi a me ka palekana o ka lāʻau lapaʻau no nā keiki ma lalo o 18 mau makahiki ʻaʻole i hoʻopaʻa ʻia, lawe ʻia i ka lāʻau lapaʻau i kēia makahiki ʻaʻole ʻōlelo ʻia.

Hiki iaʻu ke kūʻai me ka loaʻa ʻole o ka hōʻailona?

ʻAʻole hiki ke kūʻai i kahi lāʻau lapaʻau me ka loaʻa ʻole o ka lāʻau.

Hiki iā ʻoe ke kūʻai i ka lāʻau i nā mākeke āpau ma ka ʻāina o ka Lūkini Lūkini.
Hiki iā ʻoe ke kūʻai i ka lāʻau me ka lāʻau lapaʻau e like me Atoris.ʻO ka Torvacard kahi lāʻau lapaʻau like.
E mālama i ka lāʻau lapaʻau i ka mahana o ka lumi.
Hoʻomaka ke kumukūʻai o ka huahana mai 300 mau rubles.

Hoʻomaka ke kumukūʻai o ka huahana mai 300 mau rubles.

Hōʻike kumu Tulip

ʻO nā loiloi e pili ana i ka hāmeʻa ka mea kūpono.

A.Zh. ʻO Delikhina, ka mea hoʻohana maʻamau, ʻo Ryazan: "Mālama ka mea hiki iā ʻoe ke hoʻokō i nā hopena maikaʻi loa i ka hakakā ʻana i ke kolamu kiʻekiʻe ma ke koko o nā maʻi."

E.E. Abanina, Endocrinologist, Perm: "Ua hoʻokaʻawale ʻia ka lāʻau lapaʻau no ka mālama maʻi outpatient. Eia kekahi, helu mau ʻia ke koko o ka mea maʻi.

Torvacard: nā analogues, nā loiloi, nā ʻōlelo e hoʻohana ai Atorvastatin.

ʻO Karina, 45 mau makahiki, ʻo Omsk: “Ua kōkua ke hāmeʻa i nā pilikia me ka ʻōnaehana cardiovascular. Mahalo nui wau i nā kauka no ka kuhikuhi ʻana i kēia lāʻau lapaʻau. Ua maʻamau ke kumu. ”

ʻO Ivan, 30 mau makahiki, ʻo Adler: "Ua maikaʻi ka lāʻau i ke alo o ka piʻi o ka nui o ka kolamu ma ke koko. Hōʻike pinepine ʻia kēia pilikia ma muli o nā mea kīnā ʻole hiki ke piha i nā meaʻai. A pēlā ka mea. Pono wau e ʻike i ke kauka, hele i nā hoʻokolohua ponoʻeha a hoʻomāloʻeha i ka lāʻau lapaʻau. ”

Lapaʻau lāʻau

ʻO ka mea hana i ka lāʻau lapaʻau he atorvastatin, kahi mea pale i hoʻomohala ʻia no nā molekela HMG-CoA reductase. No ka hōʻemi i ke ʻano o ka hoʻoneʻe ʻana o ka mevalonic acid, ʻo ia kahi o ka sterol a me ka molekoleka.

ʻO nā molekule o ka cholesterol a me ka triglyceride he ʻāpana o nā molekamu o ka lipoproteins o ka molekui haʻahaʻa haʻahaʻa loa, i hoʻohui ʻia i ka wā o ka synthes o lākou i nā pūpū ate.

Ke hui pū ʻia nā molekuhi VLDLP me nā LDL receptors, wehe aku i ka triglycerides mai kahi lipoprotein haʻalulu haʻahaʻa loa a me nā lipoproteins hoʻoneʻe liʻiliʻi haʻahaʻa.

Komo nā molekule i ke koko a lawe ʻia ma ke kahe wai i nā wahi peripheral o ke kino.

Nā inoa ʻē aʻe o Tulip

Me ka piʻi o ka neʻe i loko o ke koko koko o ka nui o ka kolamu, a me ka hapa haʻahaʻa o ka wahi molika haʻahaʻa a me nā mololeka apoliprotein B, aia ka hopena i ka hoʻokumuʻana i kahi pathology systemic o atherosclerosis.

Eia kekahi, ʻo ka hoʻonui ʻana i ka hapa o ka lipoproteins haʻahaʻa haʻahaʻa haʻahaʻa e hoʻonui i ka nui o ka hoʻomohala ʻana i nā pathologies o ka puʻuwai naʻau a me ke kahe koko, a me ka hoʻonui ʻana i nā molika moloproteins kiʻekiʻe e hoʻemi ana i ka hōʻeha o kēia mau papa.

ʻO ka hana ikaika o ka atorvastatin e hoʻohaʻahaʻa i ka hoʻoliʻiliʻi o nā molekole cholesterol i ke koko, e hoʻonui pū ana i ka helu o nā mea LDL e hoʻonui i ka catabolism o ka molekapu liʻiliʻi molekiola haʻahaʻa, e hoʻemi ana ia ia.

ʻO ka hana ikaika o ka atorvastatin e hōʻike i kahi hopena lapaʻau maikaʻi loa i ka mālamaʻana o:

• Homozygous ona lahui hypercholesterolemia,
• Heterozygous genetic familial hypercholesterolemia,
• ʻO ka pathology primer o ka hypercholesterolemia,
• ʻO nā huina no ka hyperlipidemia.

Mālama ʻo Tulip i ka hoʻonui ʻana i ke kiʻekiʻe o nā lipoproteins kiʻekiʻe, a me ka mololeka ʻApoliprotein A1 i ke koko.

ʻO ka lāʻau lapaʻau Tulip me kahi waihona o 120.0 milligrams a me 20.0 milligrams e hoʻohaʻahaʻa i ka neʻe o ke koko:

• Ka helu huina o ka molekole kolamu ma — 29,0% — 33,0%,
• ʻO ka molekela LDL e pili ana i — 39,0% — 43,0%,
• Nā molowa APO B ma — 32,0% — 35,0%,
• E mau ana ʻo Triglycerides ma — 14,0% — 26,0%.

Hoʻopili pū me nā lāʻau ʻē aʻe

• ʻO nā lāʻau lapaʻaleʻa Antacid e hoʻohaʻahaʻa i ka piʻiʻana o tulip i ke kahawai i ka 35.0%
• Ke lawe ʻia me ka digoxin, aia ka hopena o ke kūkulu ʻana i nā ala āpau o ke kino naʻau a me nā pilikia a me ka pilikia o ka ʻoihana koko.
• ʻO nā Antibiotics o ka erythromycin a me clarithromycin pūʻulu, e hoʻonui i ka plasma o ke ʻano o ka lāʻau Tulip,
• Hoʻonohonoho ʻia ka hoʻokele ʻana o ka lāʻau hoʻokolohua hormone a me ka tulip.

Hoʻohālikelike

Hiki iā ʻoe ke mālama ʻia me nā statins e like me ke ʻano e ke kauka a mai poina e hoʻohaʻahaʻa i ka index kolesterol e pono ai ʻoe e hoʻohana i kahi meaʻai a alakaʻi i ke ʻano olakino. Hoʻohui wale nō i ka hoʻohuihui hoʻohālikelike i hiki ke hōʻemi i ka neʻe ʻana o ka cholesterol a hiki i ka hoʻomohala ʻana o ka atherosclerosis.

Ke hoʻohana nei iā Tulip ma ke ʻano he pale pale, e hōʻemi ʻia ka hopena o ka hōʻeha ʻana o ka naʻau a me ka make mai ka cerebral a me ka infarction cardiac.

Oksana, 39 makahiki: Ua kau ʻia iaʻu ma Tulip i ka wā 7,7 mmol o kaʻu pākēnē i ka pāleka, akā aia nā hopena maikaʻi loa i nā moena. Ua lawe wau i kēia statin no 4 mau mahina. Ua hoʻi hou koʻu kolamu i ka maʻamau, akā ʻaʻole i maikaʻi loa koʻu olakino.

George, 58 makahiki: Ua loaʻa iaʻu kahi maʻi kiʻekiʻe ma 14 mau makahiki. Lawe wau i nā lāʻau lapaʻau like o nā statins a me nā fibrates.

Nui kaʻu i ka maʻi maʻi, no laila lele ka piʻi nui ʻana. E like me ka atorvastatin, ua lawe au i Tulip no 2 mau makahiki.

He maʻi maʻamau ka helu lipid a ua maikaʻi loa koʻu olakino. ʻO kēia ka lāʻau lapaʻau mua ʻaʻole e hoʻokau i nā hopena ʻino i loko o koʻu kino.