Hoʻohui ʻia ʻo Atorvastatin-Teva ma nā ʻano papa i pani ʻia me ka poni kiʻi ʻoniʻoni: ʻano kākole, kokoke ke keʻokeʻo a ʻulaʻula paha, i kahakaha ʻia "93" ma kahi ʻaoʻao, a me ka kaha kiʻi kau hilinaʻi ma kēlā ʻaoʻao: “7310” no 10 mg, a me 7310 no 20 mg, a me 7310 no 20 mg. "7311", no 40 mg - "7312", no 80 mg - "7313" (10 pcs. In blisters, in a cardboard box of 3 or 9 blisters).

Helu 1 papa:

mea kūlohelohe: atorvastatin calcium - 10.36, 20.72, 41.44 a 82.88 mg, he mea e kū ana i ka 10, 20, 40 a i ʻole 80 mg o ka atorvastatin,
Nā kumuhana hou: povidone, lactose monohala, eudragit (E100) (methyl methacrylate, butyl methacrylate a dimethylaminoethyl methacrylate copolymer), sodium stearyl fumarate, sodium croscarmellose, alpha-tocopherol macrogol succinate,
palani kiʻi: opadry YS-1R-7003 hypromellose 2910 3cP (E464), polysorbate 80, hypromellose 2910 5cP (E464), macrogol 400, titanium dioxide.

Nā hōʻailona no ka hoʻohana ʻana

He hemozygous familial a non-familial hypercholesterolemia, primary hypercholesterolemia, hui pū (hui pū ʻia) hyperlipidemia (nā ʻano IIa a me IIb e like me ka helu ʻana o Fredrickson) - i hui pū me ka lipid-hoʻēmi kai i hoʻolālā ʻia e hoʻohaʻahaʻa i nā kiʻekiʻe kiʻekiʻe o ka kolamu, ka lipoprotein haʻahaʻa haʻahaʻa. me ka hoʻonui ʻana i ka cholesterol lipoprotein kiʻekiʻe-HD (HDL),
ʻO ka homchzygous familial hypercholesterolemia - i mea e hōʻemi ai i ka cholesterol nui a me ka kolamu LDL, me ka lawa ʻole o ka hoʻoulu ʻia ʻana o ka papa ʻaina a me nā ʻano lāʻau lapaʻau ʻole non-pharmacological o ke ʻano.
Serum triglycerides hoʻokiʻekiʻe (type IV ma muli o ka helu Fredrickson helu ʻana) dysbetalipoproteinemia (type III e like me ka helu ʻana o Fredrickson) - ma ke ʻano o ka launa ʻoi ʻole kaʻai ʻana.

Nā Hoʻohui

hapai a me lactation,
a hiki i 18 mau makahiki (kahi mālama ola ma atorvastatin i nā keiki a me nā ʻōpio ʻaʻole i aʻo ʻia),
ka maʻi maʻi o ka puʻukū, ke hoʻonui ʻana i ka hana o nā huina o nā pepona o kahi ʻano ʻike ʻole, ma mua o ka palena palena kiʻekiʻe o ka maʻamau (VGN) ma mua o 3 mau manawa,
huni kūpeʻe (nā keiki-Pugh nā papa A a me B),
hypersensitivity i nā ʻāpana o ka lāʻau.

Relative (e koi ʻia no ka hoʻohana ʻana i ka huahana me ka akahele):

nā hopena endocrine a me nā metabolic,
ka nānāʻoleʻole o electrolyte,
haehae
ka mōʻaukala o ka puʻuwai,
epilepsy hiki ole
nā maʻiʻeha koʻikoʻi (komo i ka sepsis),
ʻāwili manu ʻōiwi,
nā mea ʻeha, nā hōʻeha nui,
mea inu wai inu.

ʻLoe a me ke kākele

Hoʻohana ʻia ʻo Atorvastatin-Teva ma mua, i ka manawa i ka lā. ʻAʻole ʻai ka ʻai i ka hopena o ka lāʻau lapaʻau.

ʻO ka hopena mua, ma ke ʻano he kānāwai, ka 10 mg, kau ʻia nā papa i kēlā me kēia manawa o ka lā. Koho ʻia nā maʻi e ke kauka ponoʻī, ma muli o ka pae mua o ka cholesterol, ke kumu o ka mālama ʻana a me ka pane ʻana o ka mea maʻi i ka lāʻau. Hiki i ka hopena o kēlā me kēia lā mai 10 a 80 mg, pono e hoʻoponopono ʻia i ka manawa o 4 a i ʻole hebedoma paha. ʻAʻole pono nā dosis o ka lā nui ma mua o 80 mg.

I ka wā o ka ʻoihana, me ka piʻi o nā ʻāpana, pono ia i kēlā me kēia wiki 2-5 e nānā i ka pae o ka lipid plasma a, e like me ka ʻikepili i loaʻa, e hoʻoponopono i ka ʻaha.

Wahi paipai:

ʻO ka homozygous famchial hypercholesterolemia: 80 mg i kēlā me kēia lā,
he hemozygous familial hypercholesterolemia: i ka hoʻomaka o ka papa, e lawe i ka 10 mg i kēlā me kēia lā, ma ka mālama ʻana i kēlā me kēia mau hebedoma 4 mau he nui ka nui o ka nui, lawe mai ma kahi o 40 mg i kēlā me kēia lā, loaʻa ma ka hui me kahi mea hoʻoponopono o nā moʻo bile, me ka atorvastatin ma ke ʻano he lāʻau lapaʻau, hiki ke hoʻonui ʻia i kēia hopena. nā waiwai - 80 mg i kēlā me kēia lā,
ʻO ka hyperlolesterolemia maʻamau a i hui ʻia (hoʻohui (hoʻohui)) lawe i ka 10 mg i kēlā me kēia lā, ʻo kēia kaila i ka hapa nui o nā mea maʻi e hiki ai iā ʻoe ke hāʻawi i ka ʻai o ka nui o lipid, ma ke ʻano he kānāwai, he hopena lapaʻau koʻikoʻi e mālama ʻia i nā hebedoma 4 ma hope o ka hoʻomaka ʻana o ka hoʻokō a hoʻomau i ka wā lōʻihi e hoʻohana i ka lāʻau.

Ma mua o ka loaʻa ʻana o ka puʻuwai, inā pono, hiki ke hoʻemi ʻia ka hopena o ka Atorvastatin-Teva a i ʻole hoʻi i kona ʻae komo. No nā mea maʻi me ka maʻi pūpū, ʻaʻole koi ʻia ka hoʻoponopono ʻana.

No ka mea e pili ana i ka maʻi naʻau coronary a i ʻole ka hopena koʻikoʻi o nā maʻi cardiovascular, ʻoiai ke hōʻike ʻia e hoʻokau ʻia ka lāʻau me nā pahuhopu i hiki mai i ka hoʻoponopono lipid pae: ka helu kolesterol Hema i kēia ʻatikala:

Ka hoʻonohonoho ʻana a me ke ʻano o ka hoʻokuʻu ʻana

Wahi a ka ʻike i hāʻawi ʻia e ka radar, ʻo Atorvastatin Teva he mea hui o nā lāʻau lapaʻau e pili ana i ka hui o statins. He hopena kūpono ka lāʻau lapaʻau i ka hoʻoneʻe o ka huina, aia ʻo ia ka mea paʻa. Loaʻa ka lāʻau lapaʻau i ka papa paʻi, hoʻopili ʻia me ka pōpoki mai kahi kiʻiʻoniʻoni kūikawā, kahi e hāʻawi ai i ka huahana i kahi keʻokeʻo.

Kaiola mea kūlohelohe Atorvastatin Teva - Atorvastatin Calcium Trihydrate. Aia ma muli o ke kikowaena o ka mea ikaika, he nui nā pika he 21.7 a i ka 10.85 mg. Inā ʻoe e hoʻololi i ka atorvastatin he 20 a 10 mg, kēlā me kēia.

Hoʻohui i nā mea nui e hoʻokō nei i ka hana ho'ōla, aia kēlā me kēia papa i kahi nui o nā mea kōkua. Hoʻopili kēia i ka: calcium carbonate, opadray dye, magnesium stearate, cellulose, starch. Hoʻopili ka mea hana i ka lāʻau lapaʻau i nā kāla blister a me nā pahu pepa.

Nā hopena hopena

ʻO ka hapa nui o nā poʻe maʻi e hana nei i ka mālama hui ʻia me ka hoʻokomo ʻana o Atorvastatin-Teva, haʻi ʻia kona ʻoluʻolu maikaʻi. ʻOiai ʻo kēia, e like me nā mea ʻē aʻe, aia kekahi lāʻau lapaʻau i nā hopena ʻaoʻao. Ma ka kalalā nā maʻi dyspeptic (ʻeha a i ʻole constipation, heartburn, nausea, luaʻi, belching), ulcerative defects o ka ʻōpū a me ka ʻawaʻawa, nā maʻi maʻi o ka pancreas, ʻōpū hiki ke kū mai.

Ma ka kūlia hui hoʻomohala ʻia i ka myositis, myalgia, arthralgia, myopathy, rhabdomyolysis. Hiki i ke myopathy hoʻohaʻapaʻa Atorvastatin i hana ʻia e ka hopena o ka renal ma muli o ka myoglobinuria (excretion o nā huahana decriated muscle striated i loko o ka urine).

He mea kupaianaha loa ia kahi kumu lāʻau lapaʻau nā mea hoʻonāukiuki (urticaria, edema Quincke, dermatitis, erythematous lesi ʻili).

ʻO ka manawa hiki huahua cognitive, asthenization o ke kino, ka hiamoe a me ka ala, ke nānā ʻole a i ʻole ka haunaele i ka ʻike.

Nā ʻōkuhi no ka hoʻohana

Ma mua o ka hoʻomaka ʻana e lawe i Atorvastatin Teva, me ka ʻole o nā mea ʻē aʻe, pono i nā mea maʻi a pau eʻai ai i ka ʻai hypocholesterol. ʻO kēia kumumanaʻo o ka meaʻai e pono ke ʻike ʻia i ka wā kū ʻole o ka mālama ʻana i ka lāʻau lapaʻau, akā i ka wā o ke ola. E kōkua kēia ala e hoʻokō i ka pahuhopu nui o ka maʻi lapaʻau - LDL a me ka kolamu holoʻokoʻa e hōʻea i nā helu maʻamau, a nui ka pae o HDL.

Hiki ke lawe ʻia ʻo Atorvastatin Teva me ka wā ʻole o ka manawa pāʻina. Hoʻomaka i ka mālama ʻana, pono ʻoe e nānā i ka ʻōlelo o ka lipid no ka koho a a hoʻoponopono i ka hopena o ka lāʻau.

Hoʻomaka ka nui o ka dosage ma mua o 10 mg o ka atorvastatin i kēlā me kēia lā. Inā makemake ʻia, hiki iā ia ke lawe mai i hoʻokahi kikoʻī o 80 mg i kēlā me kēia lā, hiki ke hoʻokaʻawale i 2 mau kakahiaka (kakahiaka a me ke ahiahi). Inā mālama ʻia ka mea maʻi me ka cyclosporiomas, ʻo ka nui o kēlā me kēia lā o Atorvastatin Teva e liʻiliʻi (10 mg i kēlā me kēia lā). ʻO ka hoʻonui ʻana i ka ʻike o ka atorvastatin i loko o ke kaila koko (i ka hui pū me nā loli maikaʻi i ka maikaʻi o nā ʻōlaʻi lipid lipid) ʻike ʻia i ka lā 10-14 ma hope o ka hoʻomaka ʻana o ka hopena.

Hoʻohana i ka wā hāpai

ʻO ke ʻōpū ke kūlana o ke kino wahine kahi i hoʻohālikelike ʻia ai ʻo Atorvastatin Teva. Maikaʻi ka hoʻohana ʻana i ka lāʻau inā pono ka loaʻa ʻana o ka pono i ka makuahine ma mua o ka loaʻa ʻana o ka hoʻoilina hānau keiki. Ma muli o ka nele o ka ʻike noiʻi maʻi lapaʻau e pili ana paha i ke komo ʻana o Atorvastatin Teva i ka waiū umauma, ʻaʻole ia e pale ʻia i ka wā a mālama ʻia. Inā pono kahi lapaʻau me ka atorvastatin, pono e lactation.

Inā aʻo ka mākaʻi o ka wahine kūpono e pili ana i kona hāpai ʻia, a ua hoʻomaka ʻia ke mālama ʻana me Atorvastatin Teva, pono e hoʻokaʻawale ʻia kona komo ʻana i ka hiki. Pono nā mākua e mālama nei i kēia lāʻau lapaʻau e mālama pono i nā ala hilinaʻi e pale aku ai i ka manaʻo o kahi keiki. ʻO nā wahine o nā makahiki hānau, ma mua o ka hoʻomaka ʻana i ka mālama ʻana me Atorvastatin Teva, pono e loaʻa kahi kūkākūkā me kahi gynecologist.

ʻAʻole hoʻohana ʻia ka hoʻohana ʻana o Atorvastatin Teva no kahi pūʻulu o nā kānaka ma lalo o ka makahiki o ka hapa nui. ʻO kēia ma muli o ka ʻike ʻole o nā hoʻokolohua lapaʻau i ka hōʻoia a me ka palekana o ka lāʻau i nā keiki, ʻaʻole no i ʻike ʻia nā palapala i kēia.

Hoʻopili pū me nā lāʻau ʻē aʻe

E hoʻokaʻawale i nā hopena maikaʻi ʻole i ke kino, pono ʻoe e ʻike pehea e pili ai ʻo Atorvastatin Teva me nā lāʻau lapaʻau ʻē aʻe. Me ka hana like pū me nā lāʻau lapaʻau i loko o ka wā e pili ana i ka norethisterone a me ka ethinyl estradiol (waha i hoʻohālikelike ai i nā waha), e piʻi me ke ʻano o ka plasma o kēia mau mea ikaika a pau. Pono kēia hana e noʻonoʻo i ka wā e koho ai i ka hōʻona hormonal no nā wahine e koi ana i ka mālama ʻana me ka Atorvastatin Teva.

ʻO ka launa pūpū ʻole me ka atorvastatin a me nā statins e nānā ʻia i ka cyclosporine, nā lāʻau antimycotic, kekahi mau mākaʻi antibacterial mai ka macrolide pūʻulu, a me ka momona nicotinic. ʻO ka hoʻohana pono ʻana me kēia mau mea e hoʻonui nui i ka hiki ʻana o ka myopathy me nā ʻōlelo hoʻopiʻi a pau (rhabdomyolysis, hana ʻole).

Me ka hui like o Atorvastatin Teva me digoxin, ke piʻi ʻana o ka manaʻo o ka glycoside cardiac i loko o ke koko koko inā he 80 mg ka nui o kēlā me kēia lā o statin. No laila, i nā mea maʻi e loaʻa ana i ka digoxin, i mea e pale aku ai i ka hoʻopōkole ʻana o ka glycoside, ʻoi aku ka nui o ka ʻaina lipid e hoʻemi i ka 80 mg i kēlā me kēia lā.

Ka lāʻau kūʻai lāʻau

Ke kūʻai aku nei i ke Atorvastatin Teva, ke kau nei ke kumukūʻai ma ka dosage o ke ʻano ikaika, a me ke ʻola olakino i kahi i hoʻolālā ʻia ai ka kūʻai. ʻAʻole ʻokoʻa loa ka kulekele kūʻai kumukūʻai no kēia lāʻau lapaʻau mai ke kumukūʻai o nā lāʻau lapaʻau e like me ke kānāwai ma kāna hana.

I ka pane Lūkini Rūsia ʻO ka kumukūʻai kumukūʻai no kēlā me kēia paʻi o Atorvastatin Teva he 200 rubles.
Ukrainian hāʻawi ka lāʻau lapaʻau i nā papa he 20 mg ma ke kumu kūʻai o 250 UAH.

Hoʻohui a Atorvastatin-Teva

Ke hoʻolako nei nā ʻoihana lapaʻau hou e kūʻai i nā mea hoʻohālikelike o Atorvastatin Teva no ka hoʻopaʻa ʻana i ka hale a me nā kūloko haole. Heʻokoʻa wale nō kēia mau lāʻau i ka inoa ʻoihana, akā i nā huaʻōlelo o nā mea hana like like. ʻO nā mea maʻamau maʻamau o Atorvastatin Teva ʻo Atoris, Liprimar, Tulip, Torvakard, Atomax.

Nā Hōʻike Hoʻohana

ʻO ka hapa nui o nā loiloi, ka mea i hōʻike ʻia e nā kauka a me nā mea maʻi, he kūpono. ʻO nā poʻe nāna i lawe i ka Atorvastatin Teva, ua ʻike i kona hoʻomanawanui maikaʻi, ka hopena wikiwiki, e like me ka lōʻihi, a me kahi hoʻomaikaʻi ʻana i ke kūlana maʻamau. Ke nānā nei nā kauka i nā maʻi maʻi e hana nei me ka Atorvastatin Teva, e ʻōlelo ana i kona hopena ʻoi maikaʻi ʻana, ka mea i hōʻoia ʻia e nā hopena o nā ʻano noiʻi like ʻole.

ʻO Atorvastatin Teva kahi lāʻau lipid-hoʻēmi i hoʻolālā ʻia e hōʻoluʻolu i ka lipid metabolism o ke kino o ke kanaka, ʻo ia ka pale mai ia i nā hopena ʻino o ke kolamu ma nā ipu o nā mea nui. Akā, e hoʻomanaʻo nā mea maʻi e pili ana ka Atorvastatin Teva i lāʻau lapaʻau mua loa, ka ʻaha mua e pono ai ke ʻae me ke kauka ma hope o ka hoʻopaʻa ʻana i kahi loiloi piha loa!

Pākuʻi helu

Nā Papa Hoʻohui, 10 mg, 20 mg, 30 mg, 40 mg, 60 mg, 80 mg

Aia ma ka papa papa

mea kūlohelohe - atorvastatin calcium trihydrate 10.3625 mg, 20.725 mg, 31.0875 mg, 41.450 mg, 62.175 mg, 82.900 mg, like me ka atorvastatin 10 mg, 20 mg, 30 mg, 40 mg, 60 mg 80 mg,

nā mea waiwai: microcrystalline cellulose (GR M102), aniumdrous sodium carbonate, maltose, sodium croscarmellose, magnesium stearate,

nā hāmeʻa pale kiʻi: hypromellose (Pharmacoat Gr.606), hydroxypropyl cellulose, triethyl citrate, polysorbate 80, titanium dioxide (E 171).

Nā papa nāʻaina mai ke keʻokeʻo a kokoke i ke keʻokeʻo, ʻokoʻa o ka oval, me ka ʻōmaʻomaʻo biconvex (no nā dosages o 10 mg, 20 mg, 40 mg, 80 mg).

Hoʻopili ʻia nā papa ʻaina me kahi kinona mai ke keʻokeʻo a kokoke i ke keʻokeʻo, ʻolekino i hoʻohali ʻia, me kahi papa biconvex a hōʻailona ʻia i ka "30" i hoʻokahi ʻaoʻao (no ke ʻano o ka 30 mg).

Hoʻopili ʻia nā papa ʻaina me kahi kinona mai ke keʻokeʻo a kokoke i ke keʻokeʻo, ʻekekekena, me kahi alo biconvex a me ka hōʻailona "60" ma kahi ʻaoʻao (no ka dosis o 60 mg).

ʻO nā waiwai Pharmacological

Ma hope o ka lawelawe waha, ua koke koke ʻia ʻo atorvastatin. Loaʻa ka ʻike kiʻekiʻe ma hope o nā hola 1-2. hoʻonui ka Absorption i ka pā ka ʻaihue. ʻO ka hōʻea ʻana o ka presystemic ma ka huaka o ka mucous gastrointestinal tract a me ka hopena o ka "hele mua" ma o ka ate, ʻo ka bioavailability kūleʻa o ka atorvastatin he 12%, a ʻo ka bioavailability o ka ʻōnaehana he 30%. ʻO ka nui nui o ka laha ʻana o ka atorvastatin e pili ana i 381 lita. Hoʻohālikelike i nā protein protein - 98%. Hoʻolāla nui ʻia ʻo Atorvastatin e ka cytochrome P450 me ka hoʻokumu ʻana o nā derivatives ortho- a me para-hydroxylated a me nā huahana like ʻole o ka beta oxidation. ʻO ka hana pale i ka HMG-CoA reductase i ka plasma ma kahi o 70% ma muli o nā metabolite ikaika. Hoʻopili ʻia nā Atorvastatin a me kāna metabolites me ka bile ma hope o ka hepatic a me ka extrahepatic metabolism. ʻO ka hapalua hapalua o ka atorvastatin he mau hola 14. ʻO ka hapa hapalua o ka hana hoʻomehana i ka HMG-CoA reductase he 20-30 mau hola ma muli o nā metabolite ikaika.

I nā poʻe maʻi maʻi, ʻoi aku ka kiʻekiʻe o ka neʻe o ka atorvastatin i ka plasma.

I ka hihia o ka hana maʻi pareaʻe, ke piʻi ʻana o ka ʻike o ka atorvastatin a me nā metabolites i nā manawa 16.

Hoʻohui ka hana o ka hana me ka hana hewa ʻana i ke kāpili ʻana o ka koleke ma ka pehu i ka papa waikā mevalonic ma muli o ke keʻa koi ʻana i ka hoʻōla o HMG-CoA. Hōʻalo ka Atorvastatin i ka plasma cholesterol a me ka pae o ka lipoprotein ma muli o ka synta o ka synta o ke kolamu ma ka pūpū a me ka hoʻonui ʻana i ka helu a me ka hana o ka maʻi hepatic low lipoprotein receptors (LDL) ma ka pūnaehana o ka pūloli, kahi e alakaʻi ai i ka hoʻonui a me ka catabolism o LDL. Maikaʻi ʻo Atorvastatin ma ka hoʻohaʻahaʻa i nā pae LDL i nā mea maʻi me ka hypercholesterolemia homozygous maʻamau e kūʻa ʻole i ka pane lipid-hoʻohiolo ʻana. ʻO ka emi ʻana o nā pae LDL e hōʻemi ana i ka hopena o ka holomua o ka maʻi cardiovascular.

ʻ a me ke kākele

Ma mua o ka hoʻomaka ʻana o ka hoʻōla, pono ʻoe e hoʻāʻo e hoʻokō i ka hypercholesterolemia ma o kaʻaiʻai, ka hoʻomaʻamaʻa ʻana a me ka hoʻemi kaumaha ʻana i nā mea maʻi me ka momona, me ka mālama ʻana i ka maʻi kumu.Ke hoʻoholo nei i ka lāʻau lapaʻau, pono ke hoʻomau i ka mea maʻi i kahi meaʻai hypocholesterolemic maʻamau, pono ia e hahai i ka wā o ka mālama ʻana.

Lawe ʻia ka lāʻau lapaʻau i kēlā me kēia manawa o ka lā, me ke ʻano o ka ʻai ʻana o ka meaʻai. Koho ʻia ka hopena o ka lāʻau mai 10 a 80 mg i hoʻokahi manawa i ka lā, e noʻonoʻo ana i ka ʻike mua o LDL-C, ke kumu o ka hoʻouka a me ka hopena pilikino. I ka hoʻomaka ana o nā mea lapaʻau a me / a i ka manawa o ka hoʻonui i ka hoʻohālikelike o ka lāʻau, pono ia e kiaʻi i ka haʻaleka lipid plasma i kēlā me kēia mau hebedoma 2-4 a hoʻoponopono i ke ʻano inā pono.

ʻO ka hyperlolesterolemia mua a me ka hoʻohui (hoʻohui ʻia) hyperlipidemia: no ka hapanui o nā maʻi - 10 mg hoʻokahi manawa i ka lā, hōʻike ka hopena therapeutic i loko o ka 2 mau pule a hiki i ka lōʻihi ma loko o 4 mau hebedoma, me ka hoʻomohala lōʻihi, hoʻomau ka hopena.

ʻO ka Homozygous hypercholesterolemia: 80 mg hoʻokahi i ka lā (i ka hapa nui, ʻo ka hopena i alakaʻi ai i ka hōʻemi o ka ʻike o LDL-C e nā 18-45%).

ʻO ka dyslipidemia koʻikoʻi: ʻo ka dosis hoʻomaka ʻia e 10 mg hoʻokahi i ka lā. Hiki ke hoʻonui ʻia ka nui i ka 80 mg i kēlā me kēia lā e like me ka pane a me ke ahonui. Pono ke koho pono i nā ʻōhua ma ke ʻano e noʻonoʻo i ke kumu i manaʻo ʻia ai ke olakino.

Hoʻohana i loko o nā mea maʻi me nā maʻi pūpū: ʻike. "Contraindications."

ʻO ka maʻi i loko o nā mea maʻi me ka hiki ʻole o ka pilikia: ʻaʻole i hoʻopilikia ka maʻi ʻeha me ka nānā ʻana i ka Atorvastatin-Teva i ka plasma a i ʻole ka pae ʻana o ka hōʻemi i ka waihona LDL-C, no laila, ʻaʻole i koi ʻia ka hoʻoponopono ʻana o ka lāʻau.

Ke noi ʻana i nā ʻelemakule: ʻaʻohe ʻokoʻa i ka palekana, ka pono, a me ka hoʻokō ʻana i nā pahuhopu o ka maʻi lipid-downing i ka poʻe ʻelemakule i hoʻohālikelike ʻia me ka lehulehu.

Atorvastatin-Teva - kahi hana hou no ka hoʻohaʻahaʻa i ka cholesterol

ʻO ka Atorvastatin-Teva kahi lāʻau lapaʻau e kōkua ai i nā mea maʻi me ka kiʻekiʻe o ka koleka e loaʻa ana nā kīkē i kā lākou mau moku. ʻ saylelo aku nā kauka i kēia ʻōiwi hou o ka lāʻau lapaʻau, loaʻa mai synthetically.

Pehea e lawe ai i ka lāʻau lapaʻau Atorvastatin-Teva?

Aia ka lāʻau lapaʻau i ka pūʻulu o nā statins, akā hōʻike i kahi kiʻekiʻe ma mua o nā lāʻau lapaʻau like.

ʻO kahi hiʻohiʻona o ka Atorvastatin-Teva kahi palena nui loa i ka launa hoʻomalu me nā lāʻau lapaʻau ʻē aʻe.

ʻO nā ʻōlelo e hoʻohana ai i ka lāʻau lapaʻau no ka kolamu e loaʻa nā ʻike e pili ana i nā hōʻikeʻana a me nā hiʻohiʻona o ka hana. Hoʻomaʻamaʻa ʻia kekahi mea i ke ʻano o nā papa, i ka manawa e hoʻomaka ai ka kolona e hoʻoweliweli i ke olakino o ka mea maʻi, hoʻonāukiuki i ka hiki ʻana mai o nā maʻi he nui. Hoʻomaopopo ʻia nā papa Atorvastatin i ka wā e hōʻike ʻia ai nā mea hōʻike i ka:

nā maʻi o ka ʻōnaehana cardiovascular hiki ke hoʻomohala ʻia e nā genetic a me nā makahiki i pili i ka predisposition, ke ʻano kūpono ole, nā hana ʻona a me nā ulaula.
koko koko kiʻekiʻe
myocardial infarction a me ka hahau ʻana,
re-hospitalization na kumu o ka angina pectoris,
hypercholesterolemia mua a me nā hoʻoilina,
ka pono e hoʻohui i ka ʻai meaʻai kūikawā i kauoha ʻia no ka hyperlipidemia, dysbetalinoproteinemia, hypertriglyceridemia.

ʻO ke kolamu ma ia mau maʻi e hoʻoweliweli i kahi kanaka, hoʻonui i ka nui o ka make o ka make me nā ʻōpiopio. Hōʻalo ka hana o ka lāʻau lapaʻau i ka pale ʻana i kahi mea like e like me ka HMG-CoA reductase, e hoʻohuli ana i kāna mea nui 3-hydroxy-3-methylglutarin-CoA i ka mevalonic acid. A ma muli iho, hoʻomaka ka puka haʻahaʻa o nā lipoproteins e kōkua i ka hoʻēmi ʻana i ka hoʻomohala ʻana o nā maʻi cardiovascular, atherosclerosis, a hoʻemi ʻia ka nui o nā waiho kolesterol ma nā paia o nā moku koko.

Nā hopena hopena

I nā manawa pinepine (> 1/100 a ˂1 / 10)

- ʻeha i ka larynx a me pharynx, nosebleeds

- flatulence, dyspepsia, nausea, ʻohiā, constipation

- myalgia, arthralgia, ʻeha ʻana i ka ʻōpū, nā puʻupuʻu mākuhiwi, nā kipi o ke kipi, ʻeha hoʻi

- kahi hoʻololi i nā hōʻailona o ka hana ate, ka nui o ka pae o ka phosphokinase (CPK) i ka koko (ke kiʻekiʻe o ka hoʻonui ʻana i ka phosphokinase creatine ma mua o 3 mau manawa ʻoi aku i ka palena o ka maʻamau o ka maʻamau) i mālama ʻia ma ka 2.5% o nā mea maʻi e lawe ana i ka atorvastatin a me 10 mau manawa nui aʻe ma mua o ka palena kiʻekiʻe o ka maʻamau 0.4% o nā maʻi)

I kekahi manawa (> 1/1000 a ˂1 / 100)

- nā pō poʻokela, hina

- dizziness, paresthesia, hypesthesia, dysgeusia

- ka pukaʻiliʻi, ka ʻōpū o ka ʻōpū, ke belching

- ʻeha ka ʻāʻī, nāwaliwali o ka naʻau

- urticaria, ʻehaʻī, ʻeha, alopecia

- malaise, asthenia, mamae ʻōpū, peripheral edema, ʻāluhi, ʻala

- ka hopena maikaʻi no ka loaʻa ʻana o nā wahi koko keʻokeʻo i loko o ka pāʻai

- hoʻonui i nā kiʻekiʻe o ka transaminases. Hoʻololi nā liʻiliʻi, ke hele ʻana a me ka ʻole o ka koi ʻana o nā hana hōʻino. ʻO ka nui o ka maʻi (3 mau manawa ʻoi aʻe ma mua o ka palena o ka maʻamau) i ka hoʻonui ʻana i nā transaminases serum i nānā ma ka 0.8% o nā maʻi e loaʻa ana i ka atorvastatin. ʻO ka hoʻonui hoʻonui i ka dosis a hoʻohuli ʻia i nā maʻi āpau.

A hoʻouka (> 1/10000 a ˂1 / 1000)

- ʻO ka edema o Quincke, dermatitis bullous, Stevens-Johnson syndrome, necrolysis epidermal toxac, erythema multiforme

- myopathy, myositis, rhabdomyolysis, tendinopathy, tendon rupture

- hoʻonui i ke kaumaha o ke kino

Nui loa (> 1/10000 a ˂1 / 1000)

- Ka poina, hoʻomanaʻo ʻana, amnesia, hilahila

ʻO nā hopena ʻino loa e hōʻike ʻia nei, ʻo ka pinepine ke kū ʻia

- ka maʻi māmā interstitial (me ka lōʻihi o ke kau ʻana)

- ka maʻi diabetes mellitus, pili i ka ʻike a i ʻole ka ʻole o nā mea i pilikia. (Kaʻai i ke koko glucose> 5.6 mmol / l, BMI> 30 kg / m2, triglycerides kiʻekiʻe, mōʻaukala o ka hypertension)

- myopathy hoʻomalu-immuno

Hoʻopili i nā lāʻau lapaʻau

Ka hopena o nā lāʻau lapaʻau ma atorvastatin

Hoʻopili ʻia ka manawa Atorvastatin me ke komo ʻana o ka cytochrome P450 3A4 (CYP3A4) a he kekuhi o ka lawe ʻana i nā protein, no ka laʻana, hepatic absorption transporter OATP1B1. ʻO ka hoʻohana pū ʻana o nā lāʻau lapaʻau ʻo nā mea he CYP3A4 inhibitors a i ʻole ka protein protein e hiki ai ke hoʻonui i ka kukuna plasma o ka atorvastatin a hoʻonui i ka pilikia o ka myopathy. Hiki ke hoʻonui pū paha ka hopena me ka hoʻohana pinepine ʻana i ka atorvastatin me nā lāʻau ʻē aʻe e hiki ai ke hoʻoulu i ka myopathy, no ka laʻana, ka derivatives o ka fibroic acid a me ka ezetimibe.

Ua ʻike ʻia nā inhibitors CYP 3A4 e alakaʻi i ka hoʻonui nui ʻana i ka ʻike atorvastatin. I kēlā me kēia manawa, hoʻohana ka manawa like me ka CYP 3A4 inhibitors (no ka laʻana, me ka cyclosporine, telithromycin, clarithromycin, delavirdine, styripentol, ketoconazole, voriconazole, itraconazole, posaconazole a me ka liʻiliʻi o ka pale ʻana o ka protease, me ka ritonavirine, indarvinaine, a me kekahi). Inā hiki ʻole ke pale aku i ka hoʻohana like ʻana o kēia mau lāʻau me ka atorvastatin, pono ʻoe e noʻonoʻo e lawe i ka atorvastatin ma ka palena haʻahaʻa loa ʻia, a ua ʻōlelo ʻia pū ʻia nā mea lapaʻau kūpono kūpono o ke ʻano o ka mea maʻi.

Hiki i nā mea hoʻohālikelike CYP 3A4 (e.g., erythromycin, diltiazem, verapamil a me fluconazole) hiki ke hoʻonui i nā kukuna plasma o ka atorvastatin. Hoʻohana pū ka hoʻohana ʻana i ka erythromycin a me nā statins e ka hoʻonui nui o ka myopathy. ʻAʻole i lawelawe ʻia nā haʻawina o nā hana ʻoi aku ka loiloi o ka amiodarone a i ʻole verapamil ma ka atorvastatin. Ua ʻike ʻia e ka amiodarone a me ka verapamil e kāohi i ka hana o CYP 3A4, a no laila, ʻo ka lawelawe pū ʻana o kēia mau lāʻau me ka atorvastatin hiki ke alakaʻi i ka hopena o ka atorvastatin. No laila, me ka hoʻohana like ʻana o ka atorvastatin a me ke kāohi CYP 3A4 inhibitors, pono ke nānā pono i nā palena liʻiliʻi loa o ka atorvastatin, a ʻike pū ʻia ka mālama kulana o ka mea maʻi. Ma hope o ka hoʻomaka ʻana i ka mālama ʻana me kahi inhibitor a i ʻole maʻa o ka hoʻoponopono ʻana i kona ʻano, ʻae ʻia ka nānā ʻana i nā maʻi lapaʻau kūpono.

Kūkulu ka wai kīkahi i hoʻokahi a i ʻole nā mea i hoʻohui ʻia i ka cytochrome CYP 3A4 a hiki ke hoʻonui i ka hoʻoliʻi ʻana o ka plasma ma atorvstatin, ʻoi loa me ka nui o ka ʻai o ka wai ʻōpala (> 1.2 lita i kēlā lā).

Hoʻokomo ʻia CYP 3A4

ʻO ka hoʻokele ʻana o ka atorvastatin me ka cytochrome P450 3A4 inducers (no ka laʻana, me efavirenz, rifampicin, wort a St. John) hiki i ka hopena nui i ka hoʻoliʻiliʻi ʻana i ka loko o ka plasma o atorvastatin. Ma muli o ka hana o ka hopena pālua o ka rifampicin (ka hoʻoulu ʻana i ka cytochrome P450 3A a me ka pale ʻana o ka hepatic transporter OATP1B1), mālama pū ka manawa o ka atorvastatin a me nā rifampicin, no ka mea, e lawe ana i ka atorvastatin i ka lōʻihi o ka manawa ma hope o ka rifampicin e pili ana me ka hoʻohaʻahaʻa nui i ka pika plasma. Eia nō naʻe, ʻaʻole maopopo ka hopena o ka rifampicin ma ke kaola o ka atorvastatin i loko o nā poupona o ka ate, a inā hiki ʻole ke pale ʻia ka hoʻohana like ʻana, pono e nānā pono ʻia ka pono o ka mea maʻi.

Nā mea hoʻonani protote

Hiki i nā mea hoʻohiwahiwa o nā protein transport (e.g., cyclosporine) ke hoʻoikaika i nā hopena systemic o ka atorvastatin. ʻAʻole maopopo ka hopena o ka hoʻomakeʻa ʻana i nā vectors hopu hepatic i ka paʻa ʻana o ka atorvastatin i loko o nā kōpona ate. Inā hikiʻole ke pale aku i ka hoʻokahuli ʻana o kēia mau lāʻau, ua kauoha ʻia ka hōʻemi ʻana a me ka mālama ʻana i nā maʻi neʻe i ka pono.

Hoʻopuka / Gemetibea Fiber Acid Derivatives / Ezetimibe

ʻO ka hoʻohana ʻana o nā fibrates a me ka ezetimibe e like me ka monotherapy e pili me ka hoʻomohala ʻana i nā hanana mai ka ʻōnaehana muscular, a me ka rhabdomyolysis. Me ka hana like o ka ezetimibe a i ʻole nā mea i hoʻopalapula o ka fibric acid me ka atorvastatin, hiki i ke koʻikoʻi ke kūkulu i kēia mau hanana. Inā hiki ʻole ke pale aku i ka hoʻokokoke ʻana o kēia mau lāʻau, pono ia e hoʻohana i ka liʻiliʻi liʻiliʻi o ka atorvastatin e hoʻokō i kahi pahuhopu therapeutic, a me ka nānā pono ʻana i nā maʻi.

ʻO ka paʻa o ke atorvastatin a me kāna mau metabolite hoʻoikaika i ka plasma koko i hoʻohaʻahaʻa ʻia (ma kahi o 25%) aʻo ka lawe ʻana i atorvastatin me colestipol. Ma ka manawa like, ʻo ka hopena lipidemikine o ka hui pū ʻana o nā lāʻau akanovastatin a me colestipol ua ʻoi aku i ka hopena e hāʻawi i kēlā me kēia mau lāʻau kaawale.

ʻAʻole i hana ʻia nā haʻawina no ka pilina o ka atorvastatin a me ka waikawa fusidic. Ua hōʻike ʻia nā hōʻike ʻino e pili ana i nā ʻōpū, me ka rhabdomyolysis, ʻoiai e lawe ana i ka atorvastatin a me ka fusidic acid. ʻAʻole ʻike ʻia ke ʻano o kēia kaʻina. ʻAʻole pono e lawelawe ʻia ʻo Atorvastatin me ka waikawa fusidic. Inā pono e hoʻohana i ka acidus fusidic acidic, pono ke hoʻokaʻawale ʻia ke mālama ʻana me nā statins no ka lōʻihi holo ʻana o ka mālama me ka acid fusidic. Ua ʻōlelo ʻia nā mea maʻi e nīnau koke i ke kauka inā ʻike lākou i kekahi mau hōʻailona o ka nāwaliwali o ka huhū, ʻeha, a me ka ʻeha.

Hiki ke hoʻomaka hou i ka ʻoihana statin i nā lā ʻehiku ma hope o ka pau ʻana o ka waika fusidic. Ma nā hihia kūʻokoʻa loa, ke koi ʻia ka lawelawe ʻana o nā ʻōnaehana olakino lōʻihi o ka fusidic acid, no ka laʻana, no ka mālama ʻana i nā maʻi ʻino, pono ka lawelawe hui kū ʻana o ka atorvastatin a me ka waikawa fusidic e noʻonoʻo pono ʻia e hana pono ʻia ka lāʻau lapaʻau ma lalo o ka mālama mālama olakino.

ʻOiai ʻaʻohe mea i aʻo ʻia ma ka pili o ka atorvastatin me ka colchicine, ua hōʻike ʻia nā hihia o myopathy me ka hoʻohana ʻana i ka atorvastatin a me ka colchicine, a me ka atorvastatin me ka colchicine pono e hoʻohana me ka akahele.

ʻO ka hopena o ka atorvastatin i nā lāʻau lapaʻau pinepine

Me ka hana like o 10 mg o ka digoxin a me ka atorvastatin i loko o nā kekona he nui, hoʻonui ka pā i nā kūlike o ka digoxin. ʻO ka poʻe maʻi e lawe ana i ka digoxin e pono ai ka nānā pono.

ʻO ka hoʻohana like ʻana o ka atorvastatin me nā ʻōlelo kūloko i mea i hoʻonui ʻia i ka hoʻoulu ʻana o ka norethindrone a me ka ethinyl estradiol.

Pono e noʻonoʻo ʻia kēia hopena ke koho ʻana i kahi contraceptive waha i loko o kahi wahine e lawe ana i ka atorvastatin.

ʻOiai wale nō nā hihia koʻikoʻi o ka launa pū ʻana me nā anticoagulants i hōʻike ʻia, i loko o nā mea maʻi e lawe ana i ka antmaragulants Coumarin, pono ka manawa prothrombin ma mua o ka hoʻomaka ʻana o ka mālama ʻana me ka atorvastatin a pinepine pinepine i nā hoʻomaka mua o ka maʻi lapaʻau e hōʻoia e ʻaʻohe loli nui i ka manawa prothrombin. Ke hoʻopaʻa ʻia nei ka manawa prothrombin paʻa, hiki ke nānā ʻia ma ke ʻano maʻamau ʻo ia ka mea i loaʻa i ka poʻe maʻi e loaʻa ana i ka anticoagulants Coumarin. ʻAi ʻia ke ʻano hana like i ka wā e hoʻololi ai i ka make o ke atorvastatin a i ʻole ke hoʻopau ʻia. ʻAʻole i mālama pū ʻia ka hopena Atorvastatin e nā hihia o ke koko a i ʻole nā loli i ka manawa prothrombin i nā mea maʻi ʻaʻole lawe anticoagulants.

Antacids i loaʻa nā magnesium a i ʻole alumina hydroxide

Me ka hana like o nā antacids e loaʻa ana i ka magnesium a i ʻole alumina hydroxide me ka atorvastatin, ke emi nei ka kaila o ka pae i ka plasma koko.

Nā ʻōlelo kikoʻī

He hana huapili o nā iwi

ʻO Atorvastatin, e like me nā HMG-CoA reductase inhibitors (hydroxymethylglutaryl coenzyme A reductase), hiki i ka hopena ke hoʻopilikia i nā ʻuhane a me ke kumu o ka myalgia, myositis, a me ka myopathy, kahi e hiki ai ke hoʻomau i ka rhabdomyolysis, kahi kūlana e hoʻoweliweli ʻia e ka nui o nā kiʻekiʻe kiʻekiʻe o ka creatine kinase (QC) (> 10 mau manawa VPN), myoglobinemia a me myoglobinuria, hiki ke loaʻa i ka hāʻule ʻana o ka renal. ʻO ka mōʻaukala maʻi a ka mea maʻi e pono ai e mālama i ka hopena no ka rhabdomyolysis. Me ka hoʻohana pū ʻana o ka atorvastatin me ka nui o nā lāʻau, e like me ka cyclosporine a me nā poty CYP 3A4 inhibitor (clarithromycin, intraconazole, HIV protease inhibitors), ka hoʻonui nui ʻana o ka hoʻomohala ʻana i ka myopathy / rhabdomyolysis.

Ka lanakila Atorvastatin-Teva he lipid-hakumakuma nā māhele ma ka hui pu ana, me ka fibricʻakika nā mea loaʻa, erythromycin, cyclosporin, Teli-tromitsinom, immunosuppressants, me ka hui pu ana o HIV protease nā mea kūpale (saquinavir, ritonavir, lopinavir me ka ritonavir, tipranavir, ritonavir, darunavir me ka ritonavir, fosamprenavir me ka ritonavir) , me niacin, nā lāʻau lapaʻau antifungal aerosol a i ʻole nīnūnū maikaʻi a me ka colchicine, pono e kaupaona ke kauka i nā pōmaikaʻi i manaʻo ʻia ana, e huai ae ka eha a me ka nawaliwali i loko o nā nāʻiʻo, o ka oi aku i ka mua mau mahina o ka lapaau a me ka manawa paha o ka hoʻoulu nā māhele o kekahi hoʻomanaʻo i loko e pili ana me ka pilikia o ka myopathy. Ke hui pū ʻia me nā lāʻau lapaʻau aʻe ma luna, pono e noʻonoʻo pono ka hoʻohana ʻana i nā pāniʻi a me ka mālama pono ʻana o ka atorvastatin. I kēlā mau kūlana, hiki ke hāpai ʻia ka hoʻonā wā maʻamau o ka hana CPK, ʻoiai ke pale ʻole ʻia kēlā me ke nānā ʻole i ka hoʻomohala ʻana i ka myopathy koʻikoʻi.

Kuhi ʻia nā noi no ka koho ʻana i nā mea pili i nā papa ma lalo.

ʻO nā pilina o ka lāʻau lapaʻau e pili pū ana me ka nui o ka piʻi o ka myopathy / rhabdomyolysis

Kekuhi

Cyclosporin, HIV protease inhibitors (tipranavir me ritonavir), hepatitis C virus protease inhibitor (telaprevir), fusidic acid

Hōʻalo ka hoʻohana ʻana i atorvastatin

ʻO ka protease hoʻomalu HIV (lopinavir me ka ritonavir)

E hoʻohana me ka akahele a me ka haʻahaʻa haʻahaʻa haʻahaʻa e pono ai.

Clarithromycin, intraconazole, HIV protease inhibitors (saquinavir me ritonavir *, darunavir me ritonavir, fosamprenavir, fosamprenavir me ritonavir)

Mai hele i kahi hapa o ka atorvastatin

ʻO ka protease inhibitor HIV (nelfinavir), hepatitis C virus protease inhibitor (boceprevir)

Mai hoʻonui i kahi hapa o ka atorvastatin 40 mg i kēlā me kēia lā

* E hoʻohana me ka akahele a me ka haʻahaʻa haʻahaʻa haʻahaʻa e pono ai.

Atorvastatin-Teva i kuhikuhi me ka makaʻala i nā poʻe maʻi me nā mea i ʻike mua i ka rhabdomyolysis me ka hoʻomohala ʻana i ka huehue o ka maʻi renal ma muli o ka myoglobinuria a me myoglobinemia (hypothyroidism, nā hanana musculoskeletal hoʻoilina, hana ʻole i ka hopena, ka mōʻaukala o ka maʻi ate, ka hoʻohana ʻana i ka nui o ka ʻalopō ʻana o ka ʻalopona a me ka myoglobinemia (hypothyroidism, maʻi kuʻuna o nā musculoskeletal maʻi, hana ʻole i loko, he mōʻaukala o ka maʻi ate, ka hoʻohana ʻana i ka nui o ka ʻalopona ʻālaʻi o ka maʻi myoglobinuria a me myoglobinemia. kahi mōʻaukala o nā statins a i nā fibrates, ʻoi aku ka mea maʻi ma mua o 70 mau makahiki). I kēia hihia, pono ia e noʻonoʻo i ka pae o ka phosphokinase (KFK), a inā i piʻi nui ke kiʻekiʻe KFK ma nā manawa 5, ʻaʻole pono ka hoʻomaka ʻana o ka mālama ʻana. I ka wā o ka mālama ʻana, inā he hoʻopiʻi i ka hōʻeha o ka ʻeha, nā ʻeha, nā nāwaliwali, ka mahele nui, a me ka maʻi pākahi, pono ia e hoʻoholo i ke kiʻekiʻe o ka CPK, a inā he nui ka CPK i nā manawa 5, he mau manawa no ka manawa a i ʻole ke hoʻopau i ka hana me ka atorvastatin.

ʻO nā mea maʻi e kau ʻia ana e Atorvastatin-Teva, e pono e kūkākūkā koke lākou i ke kauka inā ʻaʻole i loaʻa ka ʻeha a i ʻole nā palupalu o ka naʻau, inā ua hele pū lākou me ka malaise a me ka maʻi maʻi.

Ka hana i luna

Ma hope o ka mālama ʻana me ka atorvastatin, kahi nui (ʻoi aku i 3 mau manawa i ka hoʻohālikelike ʻia me ka palena palena o mua o ka maʻamau) i hoʻonui ʻia i ka hana serum o "transaminases" ʻili.

Pono e nānā pono i nā ʻōkuhi o ka hana ate i ka wā o ka papa holoʻokoʻa o ka mālama ʻana, ka mea nui me ka nānā ʻana i nā hōʻailona lapaʻau o ka hōʻeha o ka puʻuwai. I ka hihia o kahi hoʻonui o ka ʻike i nā transaminases hepatic, pono e nānā ʻia kā lākou hana a hiki i ka palena ʻana o ke ʻano. Inā ulu kekahi i ka hana o AST a i ʻole ALT ma mua o 3 mau manawa i hoʻohālikelike ʻia me ka palena palena kiʻekiʻe o ke kumu, mālama ʻia ia i hoʻemi ʻia a hoʻopau paha ke ʻano.

ʻO nā mea maʻi e lawe ana i Atorvastatin-Teva pono e pale ʻole i ka inu ʻona. E hoʻohana me ka makaʻala ʻana i nā mea maʻi e hōʻino maikaʻi ʻole i ka waiʻona a / a i ʻole e loaʻa i ka maʻi ʻeha (mōʻaukala).

Hōʻalo ka Stroke ma o ka hōʻemi ʻana i ka Cholesterol Cholesterol Reduction (SPARCL) / Hemorrhagic Stroke

I ka poʻe maʻi me ka mōʻaukala o ka hemorrhagic stroke a i ʻole ka lacunar infarction, ʻaʻole i hoʻoholo ʻia ka hapa nui o ka ʻona a me ka pōmaikaʻi o ka atorvastatin ma kahi lāʻau o 80 mg, a no laila, ke koho ʻole ʻia nei ka hoʻohana ʻana o Atorvastatin-Teva ma kēlā mau mea maʻi. e noʻonoʻo i ka hiki ke kūleʻa o ka hana hemorrhagic kumulā.

ʻO Immuno-mediated Necrotic Myopathy (IONM)

Ma nā hihia paʻakikī loa, i ka wā a ma hope o ka mālama ʻana me kekahi mau statins, ua hōʻike ʻia ka immuno-mediated necrotic myopathy (IONM). Hoʻohana ʻia ka IONM e ka hoʻomau ʻana o ka hoʻōla ʻana o ka musum proximal a me ka nui o ka serum creatine kinase level, e hoʻomau nei ma hope o ka mālama ʻana me nā statins i hoʻokuʻu ʻia. I nā hihia i ka wā e pono ai ka mālama ʻana me ka atorvastatin i ka hoʻokūkū like me kēia mau lāʻau, pono e noʻonoʻo pono i ka hōʻemi a me ka hopena o ka hopena o ka hoʻomaʻamaʻa ʻia.

ʻO ka maʻi māmā interstitial

ʻO nā mea kupaianaha o ka maʻi pulmonary interstitial i hōʻike ʻia me kekahi mau statins, ʻoiai no ka wā lōʻihi. Inā i ka wā o ka mālama ʻana, aia nā hōʻailona o ka hoʻomohala ʻana i ka maʻi pulmonary interstitial (ke pōkole o ka hanu, ka hua ʻole ʻana o ka momona, ka ʻōpū, ka hoʻoluhi ʻana o ke kaumaha, ke maʻi), nā hana statin e pono e hoʻokuʻu ʻia.

Hoʻonui nā statins i ke koko koko, a ma kekahi mau mea maʻi me ka nui o ka ulu ʻana i ka maʻi diabetes i ka wā e hiki mai ana, hiki iā lākou ke alakaʻi i ka hyperglycemia, ma laila e ʻōlelo ʻia e hoʻomaka i ka mālama ʻana i ka maʻi maʻi maʻi. Eia naʻe, ke hoʻopiʻi ʻia kēia pilikia e nā pōmaikaʻi o ka hoʻemi ʻana i ka pilikia o nā kīʻaha koko me nā statins, no laila ʻaʻole pono ia ke kumu e pani ai i ka mālama statin. ʻO ka poʻe maʻi ma ka hopena (ka wikiwiki o ka wikiwiki o ka 5.6–6.9 mmol / L, BMI> 30 kg / m2, nā kiʻekiʻe triglycerides, hypertension) e lawe i nā statins i lalo o ka nānā ʻana o ka biochemical nānā.

ʻAʻole hoʻolako ʻia ka hoʻohana pinepine ʻana o ka atorvastatin a me ka waikawa fusidic, no laila, pono pono e noʻonoʻo i ka hiki ʻana o ka hoʻolamohuli ʻana i ka manawa o ka atorvastatin i ka wā o ka maʻi me ka fusidic acid.

Pono e noʻonoʻo i ka wā e lawe ana ʻo Atorvastatin-Teva me ka wai ʻai, ua hoʻoulu ʻia ka mea me ka atorvastatin i ka plasma, a me ka hopena o ka hopena ʻaoʻao.

Hoʻohana ʻo Pediatric

I nā keiki ma lalo o ka makahiki 18, ʻaʻole i hoʻokumu ʻia ka hopena a me ka palekana ma muli o ka liʻiliʻi o ka ʻike i ka hoʻohana ʻana.

Nā hiʻohiʻona o ka hopena o ka lāʻau lapaʻau ma ka hiki ke hoʻokau i kahi kaʻa a lawelawe paha

Hāʻawi i nā hopena maikaʻi o ka lāʻau lapaʻau, pono e hoʻomaʻamaʻa ka makaʻi ʻana i ka wā e lawe ana i kahi kaʻa a me nā mea pilikia e hiki aku ai.

E hoʻokuʻu i ke ʻano a me ka pale

10 papa i loko o kahi pā kihi Alu / Alu, ke ʻano o kahi kiʻi ʻoniʻoni polyvinyl chloride a polyvinylidene chloride a varnished alumini foil a me kahi kiʻi o polyvinyl chloride polyamide a me ka alumini foil.

3 mau pālete cell contour me nā ʻōlelo no ka hoʻohana ʻana i nā lāʻau lapaʻau ma ka'āina a me nā ʻōlelo Lūkia e waiho ʻia i loko o kahi kīpē o nā pahu.

ʻO ka lāʻau lapaʻau Atorvastatin-Teva: nā ʻōlelo, contraindications, analogues

ʻO Atorvastatin-Teva kahi lāʻau lapaʻau hypolipidemic. ʻO ka hana o ka hana o ka lipid-hoʻemi haʻahaʻa i ka hoʻemi ʻana i ka pae o ka "bad" kolesterol, a me ka nui o ka triglycerides a me nā lipoproteins o ka haʻahaʻa haʻahaʻa a haʻahaʻa. I ka huli, ua hoʻonui lākou i ka ka ʻike ʻana o nā lipoproteins density kiʻekiʻe a me ke kolamu "maikaʻi" maikaʻi.

Loaʻa Atorvastatin-Teva i ke ʻano o nā papa ʻulaʻula keʻokeʻo. Ua kahakaha ʻia ʻelua mau palapala i ko lākou alo, ʻo kekahi o lākou ʻo "93", a ʻo ka lua e hilinaʻi ʻia ma ka helu o ka lāʻau. Inā he 10 mg ka nui, inā ua kākau ʻia ka huaʻōlelo "7310", inā 20 mg, a laila "7311", inā 30 mg, a laila "7312", a inā 40 mg, a laila "7313".

ʻO ka papa hana nui o Atorvastatin-Teva ka calcium atorvastatin. Eia kekahi, ʻo ka hoʻonohonohoʻana o nā lāʻau lapaʻau me ka nui o nā mea kōkua. Hoʻopili kēia mau, no ka laʻana, ka lactose monohydrate, titanium dioxide, polysorbate, povidone, alpha-tocopherol.

Ke hana o ka hana o ka Atorvastatin-Teva

ʻO Atorvastatin-Teva, e like me ka mea i ʻōlelo ʻia ma ka mua, he ʻāpana waha i ka lipid. Ke hoʻoikaika nei kona ikaika a pau e kāohi, ʻo ia hoʻi, ke kāohi nei i ka hana a ka enzyme ma lalo o ka inoa HMG-CoA reductase.

ʻO ka hana nui o kēia enzyme ʻo ka hoʻoponopono ʻana i ka hoʻokumu ʻana o ka cholesterol, no ka mea, o ka hoʻokumu ʻana o kona mua, mevalonate, mai 3-hydroxy-3-methyl-glutaryl-coenzyme A. e hana mua ana ʻo ka kolamu synthesized, hui pū me ka triglycerides, i hoʻouna ʻia i ka ate, kahi e hui pū ai me nā lipoproteins haʻahaʻa haʻahaʻa. . ^ E Ha yM. Hoʻokomo ʻia ka mea i hoʻokumu ʻia i loko o ke kahe koko, a laila me ka mea o kēia manawa e hāʻawi ʻia i nā kino ʻē aʻe a me nā ʻāpana.

Hoʻopili ʻia nā lipoproteins haʻahaʻa loa i nā lipoproteins haʻahaʻa haʻahaʻa e ka hoʻokaʻaʻa ʻana i kā lākou mau mea kikoʻī. Ma muli o kēia hopena, hiki ke catabolism, i.e., decay.

ʻO ka lāʻau lapaʻau ka hōʻemi i ka nui o ka kolamu a me nā lipoproteins i ke koko o nā mea maʻi, ke kāohi i ka hopena o ka hoʻopili a hoʻonui i ka nui o nā mea i komo i ka ate no ka lipoproteins low density. Hāʻawi kēia i ko lākou hopu hou a hoʻoiho. ʻO ke ʻano o ke kāpili ʻana o ka lipoproteins atherogenic a hoʻemi nui ʻia. Eia kekahi, ʻo ka ʻike o ka kolamu kiʻekiʻe lipoprotein hoʻonui hoʻonui i ka triglycerides a me ka hoʻohaʻahaʻa ʻana me apolipoprotein B (ka protein lawe lawe).

Ke hōʻike nei ka hoʻohana ʻana o Atorvstatin-Teva i nā hopena kiʻekiʻe i ka mālama ʻana ʻaʻole o ka atherosclerosis wale nō, akā ʻo nā mea ʻē aʻe e pili ana me ka hana lipid metabolism, kahi o nā hopena lipid-hoʻemi i hana ʻole ʻia.

Ua hoʻokumu ʻia e pale ʻia ka hopena o ka hoʻoulu ʻana i nā maʻi e pili ana i ka naʻau a me ke kīʻaha koko, e like me ka hōʻiliʻili o ka naʻau a me nā hōʻeha.

Pharmacokinetics o Atorvastatin-Teva

Hoʻopau koke kēia lāʻau lāʻau. No nā hola he ʻelua, ua hoʻopaʻa ʻia ka kiʻekiʻe o ka lāʻau lapaʻau ma ke koko o ka mea maʻi. ʻO ke olakino, ʻo ia hoʻi, ʻo ka hoʻowalewale ʻana, hiki ke hoʻololi i kona wikiwiki.

No ka laʻana, hiki ke hoʻolōʻihi i ka wā e lawe ai i nā papa me ka meaʻai. Akā inā e emi iho ka luhi, a laila ʻaʻole i hoʻopilikia i ka hopena o Atorvastatin iho - ke hoʻomau nei ka cholesterol e like me ka nui o ka nui. Ke komo nei i ke kino, noho ka lāʻau i ka hoʻololi ʻana presystemic i ka ʻeha gastrointestinal. Hoʻopaʻa loa ia me nā protein plasma - 98%.

ʻO nā loli nui o ka metabola me Atorvastatin-Teva e hele i loko o ka ate ma muli o ka ʻike i nā isoenzymes. A ʻo kahi hopena o kēia hopena, ua hoʻohālikelike ʻia nā metabolite ikaika, nāna ke kuleana no ka hoʻopau ʻana o ka HMG-CoA reductase. ʻO 70% o nā hopena āpau o ka lāʻau lapaʻau e kū pololei ma muli o kēia mau metabolites.

Hoʻopili ʻia ʻo Atorvastatin mai ke kino me ka hua hepatic. ʻO ka manawa o ka lana o ka lāʻau i loko o ke koko e like me ka hapalua o ke kumu (a kapa ʻia ʻia ka hapalua o ke ola) he 14 mau hola. Hoʻopilikia ka hopena i ka enzyme e pili ana i kahi lā. ʻAʻole hiki ke hoʻoholo ʻia i ʻelua mau pakeneka o ka nui i ʻae ʻia e ka nānā ʻana i ka urine a ka mea maʻi. No ka poʻe maʻi me ka pilikia ʻole, e hoʻomanaʻo ʻia i ka wā o hemodialysis, ʻaʻole i haʻalele ʻo Atorvastatin i ke kino.

ʻOi aku ka kiʻekiʻe o ka lāʻau lapaʻau ma mua o ka maʻamau ma o 20% i loko o nā wahine, a ua hoʻemi ʻia ka nui o kona hōʻemi ʻia e 10%.

I nā maʻi e hōʻeha nei i ka hōʻeha o ka ate ma muli o ka inuʻana i ka waiʻona, e hoʻonui ka nui o ka piʻi e 16 mau manawa, a hāʻule ka nui o ka excretion me 11 mau manawa, i ka ʻokoʻa ʻana i ka pāʻuna.

Nā hōʻailona a me nā contraindications no ke hoʻohana

ʻO Atorvastatin-Teva kahi lāʻau lapaʻau i hoʻohana nui i loko o ka hana lapaʻau hou.

Hoʻolahalaha ʻia ka mālama ʻana i kekahi o nā maʻi a me luna nā mākaʻi ma ka nānā ʻana i kahi papa e kōkua ai i ka haʻahaʻa o ke kolamu koko (kiʻekiʻe i nā lau momona a me nā hua, nā kīʻaha, nā huaʻai, nā hua kai, nā moa, nā hua manu), a me ka hala ʻole o nā hopena mai mua noi ʻia.

Nui kekahi mau hōʻailona i hōʻike ʻo ia i mea maikaʻi loa:

atherosclerosis
hypercholesterolemia maʻamau,
? ohana heterozygous familial a non-familial hypercholesterolemia,
hoʻokaʻawale ʻia nā ʻano hypercholesterolemia (ʻano ʻelua e like me Fredrickson),
triglycerides hoʻokiʻekiʻe (ʻehā ʻano like me Fredrickson),
ka mālamaʻoleʻana o nā lipoproteins (ke kolu o ke ʻano e like me Fredrickson),
ʻO ka maʻi homozygous familial hypercholesterolemia.

Aia pū kekahi mau contraindications i ka hoʻohana ʻana o Atorvastatin-Teva:

ʻO nā maʻi ʻeha ma ke kahua hoʻoikaika a i ʻole i ke ʻano o ka exacerbation.
ʻO ka hoʻonui ʻana o ka pae o ka maʻi hepatic (ALT - alanine aminotransferase, AST - aspartate aminotransferase) ʻoi aku ma mua o ʻekolu mau manawa, me ke kumu ʻole kumu ʻole.
ʻO ka hana hema ʻole.
ʻŌpū a me ka lactation.
Na kamalii o na keiki uuku.
Hōʻike maʻalahi i ka wā e lawe ai i kekahi o nā mea pono o ka lāʻau.

I kekahi mau hihia, pono e kuhikuhi kēia mau penikala me ka akahele loa. ʻO kēia mau hihia penei:

inu waiu i a aiia,
ka hāpū palaki konopa,
ke kaulike ole ka hormonal,
pauku electrolyte,
nā maʻi hōʻea
haʻahaʻa mau koko
hopohopo maʻi pāpaʻi
epilepsy i hoʻopaʻa ʻia
nā hana nui a me nā hōʻeha hōʻeha,

Eia kekahi, e mālama pono i ka wā e lawe ai i ka lāʻau lapaʻau e pono e hana i ke alo o nā pilikia o ka ʻōnaehana o ka muscular.

Hoʻopili me nā lāʻau lapaʻau ʻē aʻe

Hoʻopili ia Atorvastatin-Teva me ka hoʻomohala ʻana i ka myopathy - nāwaliwali ikaika o ka ʻiʻo, e like me nā lāʻau āpau nona ka hui o HMG-CoA reductase inhibitors. Me ka hoʻohana pū ʻana o kekahi mau lāʻau lapaʻau, hiki i ka ulu aʻe o ke kūkulu ʻana i kēia pathology hiki ke hoʻonui nui ʻia. ʻO kēia nā lāʻau lapaʻau e like me fibrates (kekahi o nā lāʻau lapaʻau lāʻau anticholesterolemic), nā antibiotics (erythromycin a me nā macrolides), nā lāʻau antifungal, huaora (PP, a i ke ʻano nikotinic).

Hoʻopili kēia mau pūʻulu ma kahi o ka enzyme kūikawā i kapa ʻia CYP3A4, e hana ana i nā hana nui i ka metabolism Atorvastatin-Teva. Me kēia ʻano hui hoʻohui, hiki i ka nui o ka atorvastatin i ke koko ke hoʻonui i ka manaʻo no ka pale ʻana o ka enzyme i haʻi ʻia, ʻoiai ʻaʻole lapaʻau ʻia ka lāʻau lapaʻau. ʻO nā lāʻau laʻa i ka pūʻulu o nā fibrates, no ka laʻana, Fenofibrate, ke kāohi nei i nā kaʻina o ka hoʻololi o Atorvastatin-Teva, ma muli o kāna kumukūʻai i loko o ke koko e hoʻonui.

Ma Atorvastatin-Teva hiki ke alakaʻi i ka hoʻomohala ʻana o ka rhabdomyolysis - he ʻano puʻupuʻu koʻikoʻi kēia e hele nei e like me ka hopena o kahi ala lōʻihi o ka myopathy. Ma loko o kēia kaʻina hana, ʻike ʻia nā huaʻehā o nā ʻōpū mānoanoa, ua ʻike ʻia ko lākou hoʻokaʻina i ka urine, hiki iā ia ke hana i ka hala ʻole o ka renal. Ka ulu pinepine ʻo Rhabdomyolysis me ka hoʻohana ʻana o Atorvastatin-Teva a me nā hui lāʻau lapaʻau ma luna.

Inā ʻoe e kuhikuhi i ka lāʻau lapaʻau i ka nui o ka lā i ʻae ʻia i kēlā me kēia lā (80 mg i kēlā me kēia lā) me ka cardiac glycoside Digoxin, a laila he nui ka piʻi ʻana o ka neʻe o Digoxin e pili ana i ʻelima o ka huina i lawe ʻia.

He mea koʻikoʻi loa ia e hoʻohui i ka hoʻohana ʻana i ka Atorvastatin-Teva me nā lāʻau lapaʻau hānau wai e loaʻa ai ka estrogen a me nā mea waiwai ona, no ka mea ke hoʻonui ka pae o nā wahine wahine. He mea nui ia i nā wahine o ka wā hānau.

ʻO ka meaʻai, ua kuhikuhi maikaʻi ʻia e hōʻemi i ka hoʻohana ʻana i ka wai ʻai, no ka mea ʻoi aku ka nui o nā mea pono e hoʻoneʻe ai i ka huehu, ma lalo o ka mana o nā ʻano kumu nui o ka hopena o Atorvastatin-Teva e hana a hoʻonui ʻia ke kiʻekiʻe o ke koko. Hiki ke kūʻai ʻia kēia lāʻau lapaʻau i kekahi lāʻau lapaʻau me kahi laʻana.

Hāʻawi ʻia ka ʻike ma ka lāʻau Atorvastatin i ke wikiō ma kēia ʻatikala.