Hoʻopau i nā Amoxicillin: nā ʻōlelo hoʻohana no ka hoʻohana ʻana

Amoxicillin: nā ʻōlelo aʻoaʻo no ka hoʻohana a me nā loiloi

ʻAmelika inoa: Amoxicillin

Manaʻo ATX: J01CA04

Hoʻonui waiwai: amoxicillin (amoxicillin)

Mea Hana: Biochemist, OJSC (Russia), Dalhimpharm (Russia), Organika, OJSC (Rūsia), STI-MED-SORB (Rūsia), Hemofarm (Serbia)

Hoʻohou i ka wehewehe a me ke kiʻi: 11.26.2018

ʻO nā kumukūʻai i nā lāʻau lapaʻau: mai 30 mau rubles.

ʻO Amoxicillin kahi lāʻau lapaʻau, nā mea penicillin semisynthetic.

E hoʻokuʻu i ke ʻano a me ka ʻano

Nā ʻōmai helu Amoxicillin:

nā papa: kokoke i ke keʻokeʻo a i ʻole keʻokeʻo paha, pāwili-silima, me ka uhai i ka laina a me ka chamfer (10 mau pololi. a i ʻole 20 mau pcs i loko o nā poli, i loko o kahi pahu pahu pepa o 1, 2, 5, 10, 50 a i ʻole 100 mau pā, 24 pcs. nā ipu aniani i ulana ʻia, i loko o ka pūneke pepa o 1 kahe, 20 mau p. i nā pahu polū a i ʻole nā hue, i loko o ka pūlima pepa o ka 1 a i ʻole aʻa paha).
mau pūpū: gelatinous, ma ke ʻano he 250 mg - ka nui No. 2, me kahi kapa ʻōmaʻomaʻo uliuli a keʻokeʻo me ke kino melemele, ma ke ʻano he 500 mg - ka nui no 0, me kahi pāpale ʻulaʻula a me kahi kino melemele, i loko o nā kapo he ʻāpana lapalapa me ka ʻāpana. kukui keokeo i keʻokeʻo a ʻae ʻia, ʻānō ʻia kāna clumping (250 mg kēlā me: 8 mau pcs. i nā pololi, ma nā pūlani kāleka 2 blisters, 10 mau poli i nā poli, i loko o kahi pahu kāleka 1 a i ʻole 2 mau ʻāpana, 10 a 20 mau poli. i loko o kahi ʻauʻau, i kahi pūlaki o nā kāleka 1 hiki, 500 mg kēlā me kēia: 8 mau p. i nā blisters, i loko o kahi pūpū kāleka 2 iole, 8 mau p. urnyh blister i loko o ka pepa AEeAaOA 1 a hala 2, 10 pcs. ma blisters i loko o ka carton pahu 1, 2, 50 'ole he huihui' 100)
mau polima no ka hoʻohaʻawaʻi waha: poli pololi mai ka keʻokeʻo me ka kaila melemele i ke keʻokeʻo, ma hope o ka ninini ʻana i ka wai - ke kāhea melemele ʻia me ka puhā hua manuʻa (40 g kēlā me kēia i loko o nā kīʻaha wai piha me ka nui o ka 100 ml, ma loko o kahi pūpū pepa 1 pahu i loko o kahi hoʻonohonoho me ke ana ana me ka mahele o 2,5 ml a me 5 ml).

Pākaukau 1 papa:

mea kūlohelohe: amoxicillin trihydrate (ma nā ʻōlelo ʻo amoxicillin) - 250 mg a i ʻole 500 mg,
Nā mea kōkua a pau: nā māla huaʻai, ka ʻai o ka magnesium, polysorbate-80 (ʻumikūmālua-80), talc.

1 kiaʻi pahu:

mea kūlohelohe: amoxicillin trihydrate - 286.9 mg a i ʻole 573.9 mg, e pili ana i nā kiko o 250 mg a i ʻole 500 mg o amoxicillin,
Nā mea kōkua: microcrystalline cellulose PH 102, magnesium stearate, titanium dioxide (E171), gelatin.

ʻO ka hoʻohui, ʻo ia kahi mahele o ke kinipona capsule:

ʻāpana 2: cap - quinoline ʻeleʻele melemele (E104), indigo carmine (E132), ka hihia - quinoline ʻeleʻele dye (E104),
ʻokoʻa 0: cap - ka wai waiho lā i ka lā melemele i ka lā (E110), waihoʻoluʻu azorubine (E122), ke kino - dye iron oxide yellow (E172).

Ma 5 ml o ka hana hoʻopiʻi i hoʻopau ʻia (2 g o nā granule) i loaʻa:

mea kūlohelohe: amoxicillin trihydrate (ma nā ʻōlelo ʻo amoxicillin) - 250 mg,
Nā mea kōkua: sodium saccharinate dihydrate, sucrose, simethicone S184, sodium benzoate, guar gum, sodium citrate dihydrate, strawberry flav, raspberry flav, ka mea ʻono makemake me ka pua aloha.

Lapaʻau lāʻau

ʻO Amoxicillin kahi penicillin semi-synthetic, kahi lāʻau anti-syntact bactericidal-resistant ka lāʻau me ka palahalaha o ka hana. ʻO ka hoʻokūkū o ka hana ma muli o ka hiki i ka amoxicillin e hoʻoiho i ka lysis bacterial, ke kāohi ʻana i ka transpeptidase a me ka hūnā ʻana i ka synthesis o ke kūmole o ka paepae o ka pā o ka peptidoglycan i ka manawa o ka hoʻokaʻina a me ka ulu.

Nā gram-maikaʻi a me nā micro-Negro microorganisms hōʻike i ka naʻau i ka lāʻau.

ʻO Amoxicillin e hana i kēia mau pōpoki:

aerobic gram-positive bacteria: Corynebacterium ʻea kūikawā (spp.), Staphylococcus spp. (koe wale nō e hana i ka penicillinase), ʻo Bacillus anthracis, Listeria monocytogenes, Enterococcus faecalis, Streptococcus spp. ((komo Streptococcus pneumoniae),
Aerobic gram-io koʻohune: Brucella spp, Bordetella pertussis, Shigella spp, Escherichia coli, Klebsiella spp, Neisseria meningitidis, Neisseria gonorrhoeae, Haemophilus influenzae, Salmonella spp, Vibrio cholerae, Proteus mirabilis, Pasteurella septica, ....
ʻO kekahi: Leptospira spp., Clostridium spp., Borrelia burgdorferi, Helicobacter pylori.

ʻO nā Microorganism e hana ai i ka penicillinase a me nā beta-lactamases ʻaʻole e nānā i ka lāʻau, no ka mea, ua luku ʻo beta-lactamases amoxicillin.

Lapaʻau lāʻau

Ma hope o ka lawelawe waha, ua loaʻa koke ka amoxicillin a kokoke i piha (93%) i hoʻouka ʻia. ʻAʻole pā ke kīhāhā ʻana i ka ʻaina kai like, ʻaʻole hoʻopau ʻia ka lāʻau lapaʻau ma loko o ke kaona acid o ka ʻōpū. ʻO ka pae kiʻekiʻe e hiki ke hala ma hope o 1-2 mau hola a i nā helu i ka helu1515-0.003 mg / ml ma hope o kahi ala o 125 mg a me 0.0035-0.005 mg / ml ma hope o kahi hopena o 250 mg. Hoʻomaka ka hopena hopena ma ka 1 / 4-1 / 2 mau hola a lōʻihi ʻo 8 mau hola.

Loaʻa iā ia kahi kikoʻī nui. Hoʻonui ka pae kiʻekiʻe i ka kao o ka hopena o ka lāʻau. Loaʻa nā ʻike kiʻekiʻe o ka auxicillin i ka plasma, pleural a me peritoneal fluids, sputum, bronchial secretions, baga a me nā ʻoka o ka iwi, nā ʻōpū mucosa, urine, prostate gland, wahine genital organ, adipose tissue, waena pepeiao pepeiao, a me nā ʻili o nā kino. Ua komo i loko o ka pūpū pili, me ka hana maʻamau maʻamau - i loko o ka pā o ka puhaka, kahi i hiki ke hoʻonui i kona ʻikepili i ka neʻe ʻana o ka plasma ma nā manawa 2-4. Hoʻokaʻawale ʻole ka honi ʻana o ka ʻona bronchi. I ka wā i hoʻohana ʻia ai ka wā hānai, ʻo ka moʻo o ka amoxicillin i loko o nā moku o ka umbilical cord a me nā kahe amniotic he 25-30% o ka neʻe ʻana i ke kaila o ke kino o kahi wahine.

Me ka waiū umauma, ua hoʻokuʻu ʻia ka nui liʻiliʻi. Hōʻalo ʻole ka laha koko-lolo, ʻo ka hoʻomohala ʻana i ka wa o cerebrospinal i ka wā e hoʻohana ai i ka amoxicillin no ka mālama ʻana i ka meningitis (ʻo ka mumū o nā meninges) ʻaʻole iʻoi aku ma mua o 20%.

Hoʻohālikelike i nā protein protein - 17%.

Hoʻomili ʻia ia me ka piha piha ʻana me ka hoʻokumu ʻana o nā metabolites hana ʻole.

Half-ola (T_1/2) he 1–1.5 hola. Ua hoʻoneʻe ʻia ka 50-70% ma o nā keiki. ʻO kēia mau, e ka kānalua glomerular - 20%, excretion tubular - 80%. Kahi ʻia ka 10-20% ma loko o nā ʻōpū.

T_1/2 i ka hihia o ka hana renal impaired me ka creatinine clearance (CC) o 15 ml / mau minuke a i ʻole ia e hoʻonui, e hoʻonui ana i 8,5 mau hola.

Me ka hemodialysis, wehe ʻia nā amoxicillin.

Nā hōʻailona no ka hoʻohana ʻana

E like me nā ʻōlelo i hōʻike ʻia, ua hōʻike ʻia ʻo Amoxicillin no ka mālama ʻana i nā maʻi ʻeha a me nā lēʻeha i hoʻāla ʻia e nā microorganisms hiki ʻole.

nā maʻi ʻeha hanu - ʻĀpana bronchitis, exacerbation o ke kūlana branchitis, bronchopneumonia, pneumonia lobar,
nā hopena o nā kino ENT - sinusitis, tonsillitis, pharyngitis, ʻĀpilikia otitis,
nā hopena o ka ʻili a me nā ʻili palupalu - nā dermatoses i hoʻoiho lua ʻia, erysipelas, impetigo,
nā pūpū o ka ʻōnaehana genitourinary - cystitis, pyelonephritis, urethritis, gonorrhea,
maʻi maʻi gynecological - endometritis, cervicitis,
nā ʻōpū o ka ʻōpū - typhoid fever, paratyphoid fever, shigellosis (disentery), salmonellosis, ka holo kaʻa ʻemeka,
ka maʻi ulia o ka ʻōpū a me ka duodenum (ma ke ʻano o ka hui pū ʻana)
ʻōpū o ka ʻōpū - enterocolitis, peritonitis, cholecystitis, cholangitis,
maʻi meningococcal,
listeriosis (nā mahele a me nā palapala latent),
leptospirosis,
ʻO ka ʻeha o Borreliosis
sepsis
endocarditis (pale ʻana i ka wā o dental a me nā mea hoʻoweliweli hou aʻe).

Nā Hoʻohui

pūpū hema
ʻOiaʻiʻo
huhū maʻi
leukemia lymphocytic
hopohopo mononucleosis,
colitis ma muli o ka lawe ʻana i ka antibiotics (me ka mōʻaukala olakino),
hana waiū
hypersensitivity no ka antibiotics beta-lactam, me nā penicillins, cephalosporins, carbapenems,
ka maʻi kūlohelohe o nā mea āpau o ka lāʻau lapaʻau.

ʻO nā contraindications hou aʻe no kekahi mau ʻano o ka amoxicillin:

nā papa: nā maʻi maʻi (me ka mōʻaukala olakino), mai ka 10 mau makahiki a ʻo ka nui o ke kino e emi iho ma lalo o 40 kg,
nā kapapena: dermatitis atopic, he mōʻaukala o nā maʻi ʻeha o ka gastrointestinal, ʻo a hiki i 5 mau makahiki aku,
mau granule: glucose syndrome o ka galactose malabsorption, ka hapa ʻana o ka sucrose (isomaltase), intolerance fructose, dermatitis atopic, he mōʻaukala o nā maʻi gastrointestinal.

Me ka makaʻala, e ʻōlelo ʻia e hoʻokele ʻia ʻo Amoxicillin i nā mea maʻi me ka hiki ʻole o ka renal, kahi mōʻaukala o ke koko, pae ʻole i ka hoʻomohala ʻana i nā ʻano kūlohelohe (me ka mōʻaukala), i ka wā hāpai.

Eia kekahi, pono e hana mālama ʻia i ka wā e hoʻohana ai i nā papa no ka mālama ʻana i nā mea maʻi me ka mōʻaukala o nā maʻi gastrointestinal.

Nā hopena hopena

mai ka papa hana ʻana: palaki ʻana i ka ʻono ʻana o ka ʻono, ka ʻuwelu, ka luaʻi
mai ka ʻōnaehana o ka pīpī: insomnia, agitation, headache, ʻehaʻeha, haunaele, dizziness, ataxia, loli ʻano, peripheral neuropathy, ʻehaʻeha, nā hopena i kūpaʻi.
allergic reactions: wela, urticaria, flushing o kaʻili, rhinitis, conjunctivitis, erythema, eosinophilia, angioneurotic edema, eha ma ka ami, exfoliative dermatitis, Stevens - Johnson poliformnaya (multiforme) erythema, allergic vasculitis, anaphylactic kŰia reactions like me maʻi maʻi
mekameka laboratory: neutropenia, leukopenia, agranulocytosis, anemia, thrombocytopenic purpura,
mai ka urinary system: crystalluria, interstitial nephritis,
nā poʻe ʻē aʻe: tachycardia, pōkole o ka hanu, kandidiasis vaginal, superinfection (ʻoi aku ka nui o ka mālama ʻana i nā maʻi maʻi ʻaʻai a i ʻole nā mea maʻi me ka hoʻēmi kino kino).

Eia kekahi, he hiki i ka hoʻomohala ʻana i kēia mau hopena kūpono i hōʻike ʻia i ka wā e lawe ana i kekahi mau ʻano o Amoxicillin:

nā papa: nā hopena kūlohelohe i ke ʻano o ka ʻāʻī o ke kino, ka ʻeha, ka necrolysis epidermal toxic, general pousulosis exanthematous, cholestasis hepatic, eosinophilia,
mau hāleʻa: waha maloʻo, ʻeleʻele ulaula, candidiasis o ka ʻili a me nā membrane membous, he hoʻonui i ka manawa prothrombin a me ka manawa coagulation koko, ke kālai ʻia nei i ka enamel niho ma ka melemele, ʻākala a hina paha.
Granules: "ʻeleʻele lauoho ʻeleʻele", discoloration o ka enamel niho, hemolytic anemia, acute generalized exanthematous pustulosis.

Nā ʻōlelo kikoʻī

Hiki ke koho ʻia ʻo Amoxicillin inā ʻaʻohe hanana hōʻike i ka moʻolelo kikoʻī o ka mea maʻi o ka hopena maʻi kūlohelohe i nā antibiotika lika-lactam (me ka penicillins, cephalosporins). No ka makemake i prophylactic, hōʻike kahi ka hoʻokaʻawale o nā antihistamines.

Ke hoʻohana ʻia nei nā contraceptives waha e pili ana i ka estrogen, pono e aʻo ʻia nā wahine e hoʻohui pū i nā hana pale o ka contracept i ka wā o ka mālama ʻana me ka amoxicillin.

Me ka therapy anticoagulant concomitant, pono e noʻonoʻo i ka hiki ke hōʻemi i ko lākou momona.

ʻAʻole maikaʻi ka hoʻohana ʻana i nā lāʻau lapaʻau no ka mālama ʻana i nā maʻi maʻi hāpū o ka hanu.

ʻAʻole i hoʻohālikelike ʻia ʻo Amoxicillin no ka mālama ʻana i ka mononucleosis infectious ma muli o ka hiki ʻana ke hoʻomohala i ka ʻāʻī a erythematous a hōʻea i nā hōʻailona o ka maʻi.

ʻAʻole ia e kuhikuhi i hoʻohana i nā puka waha o ka amoxicillin no ka mālama ʻana i nā mea maʻi me nā maʻi o ka pēpē o ka gastrointestinal, ka mea i hele pū me ka maʻi hoʻomau a hoʻomau wale paha.

Inā hele mai nā maʻi kūlohelohe i ka wā e lawe ana i ka amoxicillin, hiki iā ʻoe ke hoʻohana i nā ʻaina antidiarrheal e pili ana i kaolin a i a attapulgite, e pale aku ai i ka lāʻau lapaʻau e hoʻolōʻihi i ka motile o ka ʻōpū.

I ka hopena o nā maʻi o ka maʻi nui me ka wai, ka wai wai i kahi kūpaʻa ʻōmaʻomaʻo a me kahi meaʻala pungent, me ka hoʻohui ʻana o ke koko i hele pū me ka maʻi a me ka ʻehaʻeha o ka ʻōpū, pono e kiʻi koke ʻoe i ke kauka. Ke hōʻike nei kēia mau ʻōuli i ka hoʻopiʻi koʻikoʻi nui o ka antibiotic therapy ma ke ʻano o ka hoʻomohala ʻana o ka clostridiosis pseudomembranous colitis.

ʻŌpū a me ka lactation

I ka wā o ka hiki ke hana ʻia, hiki ke hoʻohana ʻia ka Amoxicillin inā wale nō ka hopena e pono ai ka hopena therapeutic no ka makuahine, e like me ke kauka, ma mua o ka hoʻonāukiuki ʻana i ka wahine.

Ua hoʻohana ʻia ka hoʻohana ʻana i ka lāʻau i ka wā lactation. Inā pono e kuhikuhi i ka amoxicillin, pono nā ʻaʻa wahine e hoʻokuʻu.

Me ka hana pūnāwai paʻa ʻole

Me ka mālama aka, pono e hoʻohana ʻia ʻo Amoxicillin e mālama i nā maʻi me nā pilikia ʻole.

Hoʻohana ʻia ka nui o ka dosage maʻamau no nā papa a me nā granule i nā mea maʻi me CC ma luna o 40 ml / min, no nā kīʻaha me CC nui aku i ka 30 ml / min.

Ma nā pilikia o ka hoʻonā kino nui, pono ke hoʻoponopono ʻia. Hoʻohana ʻia ia me ke kālai ʻana iā CC ma ka hoʻohaʻahaʻa ʻana i hoʻokahi dosis hoʻokahi a i ʻole ka hoʻonui ʻana i ka wā ma waena o nā ʻāpana o Amoxicillin.

Me ka CC 15-40 ml / min, ke kau ʻia nei ka ʻōlelo maʻamau, akā ua hoʻonui ʻia ke waena o nā pulu ma nā hola 12, me CC me ka liʻiliʻi o 10 ml / min, e hoʻemi ʻia ka lāʻau ma ka 1550%.

ʻO ka palena kiʻekiʻe loa o kēlā me kēia lā ʻo Amoxicillin i anuria ʻo 2000 mg.

I ka hihia o ka hana renal impaired i nā keiki me CC ma mua o 30 ml / min, ʻaʻole koi ʻia he hoʻoponopono hoʻoponopono regimen. Me kahi CC o 10-30 ml / min, e kuhikuhi ʻia nā keiki 2/3 o ka nui maʻamau, e hoʻonui ana i ka pulu ma waena o nā dosis a hiki i ka 12 mau hola. I nā keiki me CC ma lalo o 10 ml / min, ʻo ka pinepine o ka noho ʻana o ka lāʻau lapaʻau he 1 manawa i ka lā, a i ʻole e kuhikuhi ʻia i 1/3 o ka maʻi maʻamau o nā keiki.

Hoʻohui nūhou

Me ka hoʻohana ʻana o ka amoxicillin:

ascorbic acid: kumu e hoʻonui ai i ka kiʻekiʻe o ke komo o ka lāʻau,
aminoglycosides, antacids, laxatives, glucosamine: kōkua hoʻolōʻihi a hoʻemi i ka komo ʻana,
ethanol: hōʻemi ia i ka helu o ka helu o ka amoxicillin,
digoxin: hoʻonui i kona komo ʻana,
probenecid, phenylbutazone, oxyphenbutazone, indomethacin, acetylsalicylic acid: e hoʻoulu ai i ka hoʻoliʻiliʻi o ka amoxicillin i loko o ke koko koko, e hoʻolohi ana i kona kina.
methotrexate: ua hoʻonui ʻia ka hopena o ka hoʻoulu ʻana i nā hopena o ka hopena o ka methotrexate,
kūhelu indicoagulants a me nā mea kanu i ka wā o ka metabolism o ka para-aminobenzoic acid i hoʻokumu ʻia: i ka wā o ke kahe ʻana o ka hoʻoneʻe ʻana i ka hoʻāla ʻana o ka huaʻī o K me ka huaʻōlelo prothrombin ma muli o ka pani o ka microflora pono o ka maʻi ma ka amoxicillin,
allopurinol: hoʻonui i ka pilikia o ka hoʻomohala ʻana i nā ʻano maʻi ʻalani,
nā mea hoʻohālikelike waha e: ʻo ka lawe hou ʻana o ka estrogens i loko o ka ʻōpū o ka ʻōpū, e hoʻoneʻe ana i ka hopena o ka hopena o ka contracept,
bactericidal antibiotics (cycloserine, vancomycin, aminoglycosides, cephalosporins, rifampicin): kumu a Synergistic antibacterial effects,
nā hua kanu bacteriostatic (sulfonamides, macrolides, lincosamides, chloramphenicol, tetracyclines): hāʻawi i ka nāwaliwali ʻana o ka hopena bactericidal o amoxicillin,
metronidazole: hoʻonui ka hana antibacterial o amoxicillin.

ʻO nā ʻōmole Amoxicillin: nā papa - Amoxicillin Sandoz, Ecobol, Flemoxin Solutab, Ospamox, nā kāpena - Hiconcil, Amosin, Ampioks, Hikontsil, Ampicillin Trihydrate.