He aha kaʻokoʻa ma waena o atorvastatin a me rosuvastatin?

ʻO ke kolamu kiʻekiʻe ka mea ke kumu o nā maʻi āpau o ka puʻuwai, ka ʻōpū, nā kīʻaha peripheral. ʻO Atherosclerosis (ka haʻalele ʻana o ka kolamu ma ka paia o ka lāʻau) ke kumu kumu make o ka make ma ka honua a me nā ʻāina o ka Soviet Union kahiko. ʻO nā statins kēlā mau lāʻau lapaʻau e hiki ke hoʻokahe, a me ka hoʻohana ʻana i ka manawa lōʻihi, e pani i ka hoʻomohala ʻana o ka atherosclerosis. Hoʻohālikelike ka Atorvastatin a me Rosuvastatin, ʻoiai ʻo nā ʻelele maikaʻi loa o kēia hui, e ʻae ʻoe e koho i kahi lāʻau i kēlā me kēia.

Loaʻa nā atorvastatin a me ka rosuvastatin i nā mea hana like.

Nā hana hana i ka hana

ʻO nā lāʻau ʻelua ke kūmole o ka hui like ʻole o ka lāʻau lapaʻau, a no laila ua like kā lākou ʻano hana. ʻO nā ʻokoʻa ma waena o lākou ka ikaika o ka hana: e hoʻokō i nā hopena lapaʻau like like, hiki i ka hapalua o Rosuvastatin ka hapalua o Atorvastatin.

ʻO ka hana o ka hana o ka lāʻau lapaʻau e pale i ka hoʻoneʻe i komo i ka hana o ke kumu o ka mua o ka kolamu. A ʻo kahi hopena, hōʻemi ʻia ka nui o ka kolamu a me ka haʻahaʻa lipoproteins density a haʻahaʻa loa (LDL, VLDL), ua hoʻemi ʻia ka triglycerides. ʻO lākou ke kumu o ka hoʻokumu ʻana o nā pōkopa i nā kīʻaha koko, nā puʻuwai naʻau, nā hōʻeha, a me nā mea ʻē aʻe.

Pono e hoʻohana ʻia nā lāʻau ʻelua i nā hihia penei:

• Hopu o ke kolamu koko nui,
• ʻO nā pae kiʻekiʻe o LDL, VLDL, triglycerides,
• ʻO ka maʻi naʻau Coronary (lawa ʻole i ke koko ke hoʻopau ʻia i ka puʻuwai puʻuwai) a me nā mea āpau āpau (puʻuwai puʻuwai, angina pectoris),
• Atherosclerosis o ka aorta, nā kīʻaha o ka palena haʻahaʻa, puʻuwai, nā aʻa renal,
• Me ke kiʻekiʻe o ke koko - e pale i ka hoʻomohala ʻana o ka atherosclerosis.

Nā Hoʻohui

ʻAʻole hiki ke hoʻohana ʻo Atorvastatin no:

• Ke pale ʻole i ka lāʻau lapaʻau,
• Maʻiū konehu,
• Hoʻoikaika kōpaʻa hana,
• ʻŌpū a me ka lactation.

• Ke pale ʻole i ka lāʻau lapaʻau,
• Maʻiū konehu,
• Hoʻoikaika kōpaʻa hana,
• Hōʻeha pilikia hōʻole,
• ʻO nā hoalauna o ka ʻili o ke ʻano
• Ka hona ana
• ʻŌpū a me ka lactation
• He 18 makahiki.

Nā hopena hopena

Hoʻokomo ʻia ʻo Atorvastatin:

• Nā Aliʻi
• Kaumo luhi
• Insomnia
• Nā ʻeha ʻeha
• Hoʻoikaika kōpaʻa hana,
• ʻO ka mumū o nā kino ENT,
• Huhū huhū
• ʻO ka ʻeha a me nā ʻōpū kuʻuna
• Ka mālamalama
• Allergic hopena pili.

Nā hopena hopena o rosuvastatin:

• Ka hoʻomohala ʻana i ka maʻi mellitus o ka maʻi mellitus (ʻo ka lilo aʻe o ka hana metabolism),
• ʻEha ma ke poʻo
• Huhū ʻOi
• Hoʻoikaika kōpaʻa hana,
• ʻEha ka naʻau
• Weupuaa.

E hoʻokuʻu i nā palapala a me ke kumukūʻai

Kūlike nā kumukūʻai o nā papa Atorvastatin i ka mea hana:

• 10 mg, 30 pcs. - 130 - 260 p,
• 10 mg, 60 pcs. - 300 r
• 10 mg, 90 pcs. - 550 - 710 r,
• 20 mg, 30 pcs. - 165 - 420 r,.
• 20 mg, 90 pcs. - 780 - 1030 r,.
• 40 mg, 30 pcs. - 295 - 630 p.

ʻO ke kumukūʻai o nā papa rosuvastatin ʻē aʻe nō hoʻi:

• 5 mg, 28 mau ʻopa. - 1970 p,
• 5 mg, 30 pcs. - 190 - 530 r,
• 5 mg, 90 pcs. - 775 - 1020 r,
• 5 mg, 98 pcs. - 5620 r,
• 10 mg, 28 pcs. - 420 - 1550 r,
• 10 mg, 30 pcs. - 310 - 650 r,
• 10 mg, 60 pcs. - 620 r
• 10 mg, 90 pcs. - 790 - 1480 r,
• 10 mg, 98 pcs. - 4400 r,
• 10 mg, 126 pcs. - 5360 r,
• 15 mg, 30 pcs. - 600 r
• 15 mg, 90 pcs. - 1320 r,
• 20 mg, 28 mau ʻopa. - 505 - 4050 r,
• 20 mg, 30 pcs. - 400 - 920 p,
• 20 mg, 60 mau pcs. - 270 - 740 r,.
• 20 mg, 90 pcs. - 910 - 2170 r,
• 40 mg, 28 pcs. - 5880 r,
• 40 mg, 30 pcs. - 745 - 1670 r,
• 40 mg, 90 pcs. - 2410 - 2880 p.

Rosuvastatin a i Atorvastatin - ʻoi aku ka maikaʻi?

Inā ʻoe e koho i ka pono ʻoi aku ka maikaʻi mai ka lāʻau lapaʻau, a laila pono loa ia iā Rosuvastatin. No ka mea hiki ke lawe ʻia ma kahi haʻahaʻa haʻahaʻa haʻahaʻa, ʻoi aku ka nui a me ke alapine o kona mau ʻāpana ʻaoʻao ma mua o ka Atorvastatin. Eia nō naʻe, he mea kūʻai nui loa, kūʻai ʻia e ka ʻoihana ʻo Teva a i ʻole ʻo Astrazenek (Krestor). Lawe i ka lāʻau lapaʻau i kēlā me kēia mahina, e loaʻa iā ia kahi ʻano kupanaha no kekahi mau mea maʻi e hoʻokauʻē wale ana. Ma kēia mahalo, mau i ka atorvastatin ka statin e hoʻohana maʻamau ai.

ʻO wai ka mea maikaʻi: atorvastatin a rosuvastatin? Hoike Mai

• Ua loaʻa pinepine iaʻu koʻu kolamu nui, ua make koʻu makuakāne no kahi hōʻeha ʻeha ma kahi kokoke i 40 mau makahiki. Ua nui wau e inu ana i ka Atorvastatin, ua kokoke wau e like me 40 a ʻaʻole wau e make ana, a ʻaʻole maikaʻi loa nā moku.
• ʻAʻole hiki iaʻu ke inu i kēia lāʻau lapaʻau - hoʻomaka koke ka ate i ka palaualelo, ʻike ʻia ka nāwaliwali,
• ʻO kahi lāʻau lapaʻau keu loa. ʻAʻole iʻike ʻia ka hopena o nā hopena, akā ua koi nā kauka a pau iā ia e lawe. Akā maikaʻi nā hoʻokolohua ma hope ona.

• ʻAʻole wau e hiki ke lilo i kēlā kālā i kēlā me kēia mahina, ʻoiai makemake wau. ʻAʻole hiki iaʻu ke kū i ka Atorvastatin,
• Hoʻololi nui no ka atorvastatin: ka palena haʻahaʻa, ʻoi aku ka maikaʻi,
• ʻAʻole maopopo iaʻu ke kumu e uku ai i kēlā kālā hoʻopunipuni inā hiki iā ʻoe ke inu i nā metala maʻalahi.

He aha nā helu?

Aia nā statins i kahi hui liʻiliʻi nui o nā lāʻau lapaʻau i hoʻohana ʻia e hoʻohaʻahaʻa i ka ʻike o LDL a me VLDL i ke koko.

Ma ka hana lapaʻau hou, ʻaʻole hiki ke hoʻokaʻawale ʻia nā statins no ka pale ʻana a me ka mālama ʻana i ka atherosclerosis, hypercholisterinemia (hui ʻia a i ʻole homozygous), a me nā maʻi cardiovascular.

Ma keʻano holoʻokoʻa, loaʻa i nā lāʻau lapaʻau o kēia pūʻulu ka hopena like i ka therapeutic, i.e. haʻahaʻa haʻahaʻa LDL a me VLDL. Eia nō naʻe, ma muli o ka ʻano o ka hana like a me nā mea kōkua, aia kekahi mau ʻokoʻa e pono e noʻonoʻo i ka manaʻo e pale ai i nā hopena ʻino.

ʻO nā statins i hoʻokaʻawale ʻia ma I (Cardiostatin, Lovastatin), II (Pravastatin, Fluvastatin), III (Atorvastatin, Cerivastatin) a me IV hanauna (Pitavastatin, Rosuvastatin).

Hiki i nā loina ke kūlohelohe a me ke ʻano kumu. No kahi loea kūikawā, koho nui nā koho o nā lāʻau haʻahaʻa haʻahaʻa, aū, a i ʻole ma ka mea maʻi.

Hoʻohana pinepine ka Rosuvastatin a me Atorvastatin e hoʻohaʻahaʻa i ka cholesterol. ʻO kēlā me kēia mau lāʻau lapaʻau he mau hiʻohiʻona:

ʻO Rosuvastatin e pili ana i nā statins o ka hanauna ʻehā. Hoʻopiha piha ʻia ka lipid-hoʻohaʻahaʻa i ka nui o ke ʻano o ka mea ikaika. Hoʻohana ʻia ia ma lalo o nā mea kūʻai aku, no ka laʻana, Krestor, Mertenil, Rosucard, Rosart, etc.

Na Atorvastatin no nā statins hanauna he III. E like me kona aniani, he kumu synthetic, akā loaʻa kahi kiʻekiʻe o nā mea ikaika.

Aia kahi mau like like o ka lāʻau like Atoris, Liprimar, Toovacard, Vazator, etc.

ʻO ka hiʻohiʻona kemika o nā lāʻau

Loaʻa nā lāʻau ʻelua i nā palapala papa. Hāpai ʻia ʻo Rosuvastatin i hoʻokahi mauʻano - 5, 10 a me 20 mg o ka hana like. Hoʻokuʻu ʻia ʻo Atorvastatin i kahi waihona papaʻi o 10,20,40 a me 80 mg o ka mea kanu ikaika. Aia ma lalo kahi papa e hoʻohālikelike ai i nā mea kōkua o nā mākaʻi kaulana o nā statins ʻelua.

ʻO ka hoʻololi nui ma waena o Rosuvastatin a me Atorvastatin ko lākou mau wahi physicochemical. ʻO ka pōmaikaʻi o rosuvastatin e maʻalahi ia i wāwahi i ka plasma koko a me nā waiila'ē aʻe, i.e. is hydrophilic. Loaʻa i ka Atorvastatin kahi hiʻohiʻona: soluble i fats, i.e. he lipophilic.

E pili ana i kēia mau hiʻohiʻona, kuhikuhi nui ka hopena o Rosuvastatin i nā pūpuna o ka parenchyma ate, a me Atorvastatin - i ke ʻano o ka lolo.

ʻO ka pharmacokinetics a me ka pharmacodynamics - nāʻokoʻa

Aia ma ke kahua o ka lawe ʻana i nā papa, ʻokoʻa nā ʻokoʻa ma ko lākou lawe ʻana. No laila, ʻaʻole i hilinaʻi ka hoʻohana ʻana o rosuvastatin i ka manawa o ka lā a i ʻole ka pāʻina. ʻAʻole pono e hoʻopau Atorvastatin i ka manawa like me ka meaʻai, e like me hōʻeha kēia i ka hoʻopili ʻana o ka mea hana. Loaʻa ka ʻike kiʻekiʻe loa o Atorvastatin ma hope o 1-2 mau hola, a ʻo Rosuvastatin - ma hope o 5 mau hola.

ʻO kekahi ʻano ʻē aʻe ma waena o nā statins ʻo kā lākou metabolism. I ke kino o ke kanaka, ua hoʻohuli ʻia ʻo Atorvastatin i kahi ʻano hana ʻole me ka hoʻohana ʻana i nā huina o ka ate. Pēlā e pili pili ana ka hana o ka lāʻau i ka hana o ke ake.

Hoʻokomo ʻia ia me nā lāʻau lapaʻau i hoʻohana pinepine ʻia me Atorvastatin. ʻO kona analogue, ma kahi ʻē aʻe, ma muli o ke kumu haʻahaʻa, ʻaʻole i kū like ka lāʻau lapaʻau ʻē aʻe. ʻOiai ʻaʻole kēia e hoʻopakele iā ia mai ke alo o kahi hopena maikaʻiʻole.

Hoʻopili ʻia ʻo Atorvastatin me ka bile.

ʻAʻole i like me nā statins he nui, ʻaʻole kokoke i like ka mole o Rosuvastatin i loko o ke akeo: ʻoi aku ma mua o 90% o nā mea a ke aʻe a ke hoʻololi ʻole ʻia e nā ʻōpū a lawe wale ʻia nā 5-10% e nā keiki.

Pono a me nāʻike ʻē aʻe

ʻO ka hana nui o ka lāʻau statin e hōʻemi i ka neʻeʻana o ka LDL i ke koko a hoʻonui i ka kiʻekiʻe o ka HDL.

No laila, ke koho nei ma waena o Atorvastatin a me Rosuvastatin, pono mākou e hoʻohālikelike i ka hoʻomaikaʻi ʻana i ka cholesterol.

Ua hōʻike ʻia kahi noiʻi ʻepekema hou loa he lāʻau ʻoi aku ka maikaʻi o ka rosuvastatin.

Hōʻike ʻia nā hopena hōʻike hoʻokolohua ma lalo nei:

1. Me nā like pū o nā lāʻau lapaʻau, hoʻemi ʻo Rosuvastatin i ka kolamu LDL e ka 10% ʻoi aku ka maikaʻi ma mua o kāna hoʻohālikelike. Loaʻa kēia pono i ka hoʻohana ʻana i ka lāʻau lapaʻau no nā poʻe maʻi me ka hypercholesterolemia koʻikoʻi.
2. ʻO ke alapine o ka hoʻomohala ʻana o nā hoʻopiʻi cardiovascular a me ka hoʻomaka ʻana o kahi hopena fatal e kiʻekiʻe aʻe ma Atorvastatin.
3. ʻO ka ulu ʻana o nā hopena ʻino e like nō no nā lāʻau ʻelua.

ʻO ka hoʻohālikelike o ka maikaʻi o ka hōʻemi ʻana i ka neʻe o ka "bad" cholesterol i hōʻike i ka mea ʻoi ke maʻi ʻo Rosuvastatin. Akā naʻe, mai poina ka mea e pili i nā mea e like me ka hele ʻana o nā contraindications, nā hopena a me nā uku. ʻO ka hoʻohālikelike o nā kumukūʻai o nā lāʻau ʻelua i hōʻike ʻia i ka papaʻaina.

No laila, ʻo ka atorvastatin kahi analogue haʻahaʻa e hiki ai i ka poʻe haʻahaʻa haʻahaʻa ke kālā.

ʻO ia ka mea e noʻonoʻo ai i nā mea maʻi e pili ana i nā lāʻau lapaʻau - ke hoʻomanawanui maikaʻi nei ʻo Rosuvastatin a ʻaʻohe pilikia. Ke lawe ʻia, hoʻemi ʻia ka cholesterol maikaʻi ʻole

Ke hoʻohālikelike nei nā lāʻau lapaʻau e hoʻopau i kēia manawa o ka hoʻomohala ʻana i ka lāʻau lapaʻau, nā kūlana mua ma waena o nā papa kolamu maikaʻi loa e noho ʻia e nā statins o ka hanauna ʻehā, me ka komo pū ʻana Rosuvastatin.

E pili ana i ka lāʻau lapaʻau Rosuvastatin a me kona mau mea i hoʻohālikelike ʻia i ke wikiō ma kēia ʻatikala.