Naʻi maʻi mellitus

ʻO nā ʻina no ka ʻike ʻana i ka hyperglycemia transit e pili ana i ka hoʻoholo ʻana o nā protein glycosylated, ʻo ka manawa o ka neʻe ʻana i loko o ke kino ma waena o 2 a 12 mau pule. Hoʻokaʻaʻike i nā glucose, e hōʻiliʻili lākou iā ia, e like me ia, he ʻano hana hoʻomanaʻo e mālama ai i ka ʻike e pili ana i ke kiʻekiʻe o ka glucose i ke koko ("hoʻomanaʻo i ke koko glucose hoʻomanaʻo"). ʻO ka Hemoglobin A i nā kānaka olakino he hapa liʻiliʻi o ka hemoglobin A1c, kahi i loaʻa ka glucose. ʻO ka pālua o ka hemoglobin glycosylated (HbA1c) ka 4-6% o ka nui o ka hemoglobin.

I nā maʻi me ka maʻi mellitus me ka hyperglycemia mau a me ka hoʻomanawanui i ka hoʻohaʻahaʻa glucose (me ka hyperglycemia transient), ʻo ka hoʻohui ʻana o ka glucose i loko o ka molekula o ka hemoglobin, e hui pū ʻia e ka piʻi nui o ka hapa HbAic. ʻO kēia manawa, ua loaʻa kekahi mau huaʻōlelo hemoglobin liʻiliʻi, ʻo Ala a me A1b, kahi i hiki ai ke hoʻopaʻa i ka glucose, ua loaʻa. I ka poʻe maʻi me ka maʻi mellitus, ʻo ka nui o nā ʻikepili o ka hemoglobin A1 i loko o ke koko, ʻoi aku i ka 9-10% - ke ʻano nui o nā mea olakino.

ʻO ka hyperglycemia transient ka mea e hele pū me ka piʻi o nā pae o ka hemoglobin A1 a me A1c no 2-3 mau mahina (i ka wā o ke ola o ke koko hāulaʻa) a ma hope o ka hoʻālikelike ʻana i nā pae koko koko. Hoʻohana ʻia nā kolom chromatography a i nā ʻano calorimetry e hoʻoholo i ka hemoglobin glycosylated.

ʻO ka wehewehe ʻana o IRI

ʻO ka hoʻokolohua me tolbutamide (e like me Unger a me Madison). Ma hope o ka nānā ʻana i ke kōpaʻa koko ma kahi ʻōpū ʻole, 20 ml o kahi ʻōmole 5% o ka tolbutamide e hoʻopili pono ʻia i ka mea maʻi a ma hope o 30 mau minuke o ke koko ua ʻike hou ʻia. I nā poʻe olakino olakino, aia ka emi o ke kō o ke koko ma mua o 30%, a i nā mea maʻi me ka maʻi maʻi - ma lalo o 30% o ka pae mua. I ka poʻe maʻi me ka insulinoma, hoʻokaʻawale ke kō o ke koko ma mua o 50%.