Ke Alarm mole: nā kauoha no ka hoʻohana ʻana

ʻAʻole no ka nui o kā mākou makemake e ulu i kahi hua maikaʻi me ka loaʻa ʻole o ka lāʻau lapaʻau hoʻokahi, ʻokoʻa, ua mamao loa ia.

I ka hapanui pinepine me nā pepeke pepeke a me nā maʻi o nā mea kanu e kaua aku ʻoe me nā insecticides - hoʻohui pūhui ʻona kūikawā, hoʻohana i mea make i nā iniseti, kā lākou huaʻī, ko lākou hua, a me ka nematode a me nā ʻōpī.

Insecticide "Alatar": ʻike laulā

Means "Alatar" pili i ka hui o nā lāʻau lapaʻau me ka hana pili-ʻili. He kūpono kūpono ia no ka hoʻomohala maʻi o ka māla a me ka māla lau i nā mea kanu, hōʻoia pono i ka pūnaewele mai nā maʻi. Kōkua ka lāʻau lapaʻau e hoʻopā me nā aphids, nā momi lau, nā ʻōpū, nā pua pua, nā ʻōpala ʻopa, tinnitsa, raspberry a me ka strawberry weevil a me nā mea kipa ʻē aʻe i hoʻopuka ʻole ʻia.

ʻO ka iniseti wehewehe ʻia e kūʻai aku ana ma ke ʻano o kahi emulsion paʻa i hoʻokomo ʻia ma 5 ml ampoules a i ʻole mau pahu 25 ml. E hoʻomākaukau i ka hoʻonā hana hana, ua hoʻoheheʻe ʻia nā ʻike o nā ampoule ma kahi liʻiliʻi o ka wai (e like me 2-3 l), a laila hoʻohui hou ʻia ka wai a hiki i kēia ʻano. Pono kēlā me kēia moʻomeheu i kāna kumu ponoʻī o Alatar, e like me ka mea i hōʻike ʻia ma nā ʻōlelo aʻo no kona hoʻohana. Eia nō naʻe l? ule huina? pono 10 e l (pono e hui pū ʻia ka hopena.

Hoʻohana kumu a me nā hana hana

Inā manaʻoʻiʻo ʻoe i nā loiloi o nā mea noho o ke kauwela, a laila "Alatar" kope me nā hana ʻoi aku ka maikaʻi ma mua o nā hana like ʻole. Ua hiki ke hoʻokō ʻia nā hopena like no ka hiki o nā mea ʻelua o nā mea hoʻomohala i loko o kāna ʻano: cypermethrin a me ka malathion. No Malathion (kahi karbofos) nona ka papa o ka pūnao organophosphorus me ka laulā o ka hana. "Alatar" mālama pono i nā mea kanu mai nā aphids (ʻo ia hoʻi, ʻo ia ka mea e hūnā pinepine ai i ka pae) a mālama pū i nā hōʻeha nui o nā pepeke a me nā ʻalī.

ʻO ka lua o nā mea i kāhi ʻia - kahi pepeke manuahi i hoʻopili ʻia, ka mea i hōʻike ʻia e ka hana kiʻekiʻe nui a waiho ʻia ke kālai ʻana i ka ʻōnaehana o nā pōpoki, ma ka pākeke a me nā hua ʻōpiopio. Eia kekahi, komo ka Alatar i kahi adhesive kūikawā e hana ana i kahi hana kūikawā - pale ia i ka hopena i ka neʻe ʻana i ka lau a holoi ʻole ʻia e ka ua (E ʻike ʻia ka ʻike e pili ana i kēia i nā ʻōkuhi no ka hoʻohana, kahi i pili ʻia me ka lāʻau lapaʻau, a i ʻole ke kuhikuhi ʻana mai ka ʻoihana).

Nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana i ka lāʻau "Alatar" no nā māla hortikolika

E like me kā mākou i ʻike ai ma mua, pono nā ʻōiwi like ʻole i ka nui o ka lāʻau i wehewehe ʻia, no laila ma mua o ka hoʻomau ʻana me ke kahe o ka wai hana, pono ʻoe e hoʻoholo i ka dosage. E kamaʻilio e pili ana i ka huahana Alatar a me kāna ʻōlelo aʻo no ka hoʻohana ʻana, ʻaʻole mākou e hana i nā pākaukau, akā wehewehe wale i ka dosage no nā mea kanu maʻamau i ulu i kēia lā.

Kāliki, ʻuala, kāloti, kāloti, nā hua lāʻau

Hoʻuʻu ʻia ʻo Cibe me Alatar wale nō i ka wā ulu ulu nei. No ka hoʻomākaukau ʻana i ka hoʻonā hana, ua hoʻoheheʻe ʻia nā ʻike o nā ampoule (5 ml) i 4 lita o ka wai, ma hope o ka hoʻoheheʻe ʻia ʻana o nā mea kanu me ka hua like hopena. ʻO ka hoʻohanaʻana i ka lāʻau lapaʻau i kēia hihia he 4 lita no 100 m². Hoʻohana ʻia ka ʻōpala i ka hoʻopau ʻana i nā pilikia o ka pata keʻokeʻo, nā ʻōpala kāpili, nā ʻōpala, nā kīʻaha, nā ʻāpana lau.

ʻO ka pīpī ʻana me ka hoʻomākaukau mea kanu e lawe ʻia wale me ka ʻike nui o nā pōpoki. E like me ka lā ma mua, no 100 m² e pono ai ʻoe i 4 lita o ka wai o ka hana, a he 10 mau lā ka huaʻōlelo no ka hana manual. Hoʻohana ka inikini i ke kaua e kūʻē Kolika ʻoka popoki uukui a ka pipi.

Ua hoʻomākaukau ʻia kahi hana hana e like me ka papa hana like no ka ʻokiʻoki ʻana i nā nati, kāloti a me nā hua lāʻau: 5 ml o ka lāʻau lapaʻau e pono e hoʻoheheʻe ʻia i 4 lita o ka wai. I kēia mau hihia, e kōkua aku ana ka lāʻau pesticide Alatar (e like me nā ʻōlelo aʻo) Lāʻau ʻōpala pua, lele ke ʻano a pale aku i nā strawberry mai raspberry-ʻōpala hua-hua.

ʻO ka pīpī ʻana i ka kumulāʻau māla kīʻaha, a me nā pears a me nā quinces, e hana ana i ka wā ulu o ka lāʻau, ma hope o ka ninini ʻana i ka 5 ml o ka lāʻau i ka 10 l o ka wai. I ka awelika, e pili ana iā 5 lita o ka hana hana i hoʻopau ʻia i hoʻokahi lāʻau. 3 l - no nā kuʻi ʻōpio a me 6-8 l - no ka kanu ʻana i ka pākeke. ʻO nā ʻenemi nui loa o ka lāʻau āpau he mau māmā, nā pua pua, nā aphids, nā peni, nā momi, nā alapiʻi, nā ʻōpala, a me Alatar ke kime me ka maikaʻi.

No ka mālamaʻana i nā currants a me nā gooseberries, 5 ml o ka lāʻau lapaʻau pono e hoʻoheheʻe i 5 l o ka wai.

ʻO ka holo o ka kahe e hana i ka wai i luna i ka 1 leka no kēlā me kēia kumu lāʻau, e kōkua ana i ka hoʻopauʻana i nā aphids.

ʻO nā kumulāʻau ornamental, nā lāʻau a me nā mea kanu pua

Kōkua ke kōkua ʻo Alatar me ka hōʻalo i nā pōpoki i ka wā e ulu ana i nā lāʻau ornamental a me nā kumulāʻau ma kāna wahi. Pono kēia mau mea kanu i ka mālama kūikawā, no laila ʻeli ʻia lākou i ʻekolu mau manawa: ma mua a ma hope o ka pua ʻana, a i ka wā e ulu ana. ʻO ka hoʻopau ʻana o ka hopena hoʻonā ʻo 1.5 lita no 10 m², a ʻo ka pipi ʻana ua hana maikaʻi loa i ke kakahiaka a i ke ahiahi paha (ma hope o ka lā), i ka mālie a me ka maloʻo. Pono e maloʻo nā lau āpau o ka mea kanu, ʻo 4 mau hola ma mua o ka ua o ka ua i manaʻo ʻia.

Hoʻomaopopo ʻia ke ʻano kiʻekiʻe no ke kaʻina hana e like me + 12 ... + 25 ° С. "Alatar" no ka pale inika nā mea pale i mālama i nā kumulāʻau hānai a hua manu ʻai ʻai, dipterans a kāhea i ka poʻe kāʻei i ʻike ʻole ʻia (ua hōʻike ʻia kēia ma nā ʻōkuhi). No ka mālamaʻana i nā mea kanu, 5 ml o ka lāʻau (hoʻokahi ampoule) e hoʻoheheʻe ʻia i ka 3.5 l o ka wai.

He kūpono ʻo "Alatar" no ka hoʻōla ʻana i nā mea kanu kūloko, a ʻoiai ʻaʻole i hōʻike ʻia ka nui o nā lāʻau i manaʻo ʻia no nā pua i loko o nā ʻōkuhi no ka hoʻohana ʻana, hiki iā lākou ke hoʻouka ʻia me ka mea like ʻole āu e hoʻohana ai no ka hoʻouka ʻana i nā lāʻau kūleʻa.

Loaʻa nā pono o ka hoʻohana ʻana i ka lāʻau "Alatar" e kāohi ai i nā iniseti

Loaʻa nā mea hoʻohana āpau i hoʻohana i kēia lā i kekahi mau waiwai kūpono, akāʻo Alatara, i hoʻohālikelike ʻia me nā mea hoʻokūkū Loaʻa ia ia nā pono:

• Loaʻa iā ia kahi hana kiʻekiʻe, ʻo ia ka mea i loaʻa i nā ʻelua o nā mana i hana i ka luku piha ʻana i nā mea pōpilikia hanake.
• piha kahi hāmeʻa kūikawā e pale ai i ka holoi ʻana a ʻole hoʻi i ka lawe ʻole ʻana i ka lāʻau lapaʻau mai nā lau o nā mea kanu hānai,
• He manawa lōʻihi paha ia o ka hoʻohana ʻana, ka mea i wehewehe ʻia e ka helu haʻahaʻa haʻahaʻa o ka huahana (ka hapanui pinepine, he 10 ml wai nui a lawa no kekahi ampoule me kahi punawai o 5 ml).

ʻO nā hana palekana i ka wā e hana pū me ka lāʻau lapaʻau

Ke hana pū nei me kekahi kīmaha, pono e mālama mau ʻia nā mālama palekana. ʻO ka mea mua, ʻoi aku ka maikaʻi o ka hoʻokō ʻana i ka hoʻoilo ma ke anuanu a i ʻole he makani liʻiliʻi mai ou. ʻO ka lua, e hōʻoia e uhi me ka lole o nā ʻāpana āpau o ke kino (e kau ma nā pāpale lima a me kahi pāpale). ʻAʻole lawa ka nui o nā aniani a me kahi mea hanu, no ka mea hiki iā ʻoe ke pale palekana i kou mau maka, digestive tract a me nā ʻōpū hanu. E maopopo hoʻi i ka wā e hoʻokō ai i ke kaʻina hana ʻaʻohe kanaka a holoholona paha kokoke mai.

Mai ulaula a ʻai ʻole paha i ka wā nalo. Inā, ma muli o nā hana āpau, ke hoʻomau ʻia ka makika i nā maka a i ʻole i ka ʻili, pono e holoi ʻia me ka nui o ka wai maʻemaʻe. Inā hoʻokomo ke ʻano i ke kino ma ka waha, e holoi maikaʻi iā ia i ka wai, inu i nā aniani o ka wai mahana a i ka waiū paha a hoʻihoʻi i ka arika ma ka helu o 1 g i ka 1 kg o ka paona o ke kino. Ma hope o kēia, ma ka hoʻonāukiuki ʻana i ka pā o pharyngeal posterior, pono ka luaʻi.

Ma hope o ka hoʻopiha ʻana i ka hana, holoi holoi kou mau lima me ka umauma, a inā he mea ʻoi aku ka maikaʻi o ka ʻauʻau.

Ke mālama nei a me ke ola o ka noho o Alatara

"Alatar" ma ke ʻano he hopena no nā aphids, nā pōpoki, nā ʻōpio a me nā mea maʻi ʻē aʻe e hoʻolako ʻia ma nā ʻano o nā ampoules (5 ml) a i ʻole 25 ml mau pahu. I kekahi hihia, ʻaʻole pono ʻoi aku ka ola o ka noho papa o nā mea kaua ʻelua mau makahiki ʻelua. I kēia manawa āpau, pono ka pā peke me ka lāʻau lapaʻau i loko o kahi lumi maloʻo a pouli hoʻi me nā hōʻailona o ke ana o ka -5 ° С ... + 25 ° С, kahi hoʻokaʻawale mai nā huahana meaʻai a me nā lāʻau lapaʻau. Eia kekahi, ʻaʻohe pono o nā keiki a me nā holoholona e pono ai. Eia kekahi, pono e pale i ka huahana mai ke ahi.

ʻO kaʻoiaʻiʻo, ʻo ka hana ʻana i ka māla a i ka māla hiki ʻaʻole ke kapa ʻia he hana maʻalahi, Eia kekahi, ʻo ka hopena hope loa ʻaʻole ia e hilinaʻi mau i ka maʻa mau. Hoʻopili i ke ʻano o ke kanaka, ke ʻano ikaika o ka manawa a me ke kūlana o ka manawa, akā ʻaʻole kēia ke kumu o ka hoʻomau iā ʻoe. ʻO ka loaʻa ʻana o nā mea kanu me Alatar e kōkua aku ʻoe iā lākou e hoʻopiʻi i kekahi o nā pilikia nui loa - nā pōpilikia, a me nā mea kanu maikaʻi hiki iā lākou ke hoʻomanawanui maikaʻi i ka makani anu a i ka ua.

Ke ʻano o ka noi

ʻAʻole he hoʻonui hou aʻe o ka dosage i kumu e hoʻonui i ka hopena therapeutic, akā i nā hihia kaawale, hiki ke hoʻonui ʻia i ka nui o kēlā me kēia lā i 6 mg. Lawe ʻia ka papa laʻana i kēlā me kēia lā i ka manawa o ka papa nui (mua). Pono e holoi ʻia nā papa i ka wai o ka nui o ka wai. Inā ka 1 mg o ka glimepiride e hoʻomōhala i ka ulu ʻana o ka hypoglycemia, ʻoi loa, no ka mea maʻi e mālama i ka maʻi maʻi, e lawa kaʻai. I ka wā o ka mālama ʻana, pono paha e hoʻemi i ka nui o ka glimepiride, i pili pū me ka hoʻomaʻamaʻa ʻana o ka metabolism a me ka hoʻoulu ʻana o ka ʻiole i ka insulin.
Hiki ke hoʻohana ʻia ka lāʻau Altar e like me monotherapy, a i hui pū me ka insulin a me ka metformin.

Nā hopena hopena

Nā hopena ʻaoʻao mai ka hoʻohana ʻana i ka lāʻau lapaʻau Alarahi hiki ke hiki mai ka ʻōnaehana olakino: paʻakikī - leukopenia, thrombocytopenia, granulocytopenia, agranulocytosis, hemolytic anemia, pancytopenia. Hiki ke hoʻololi hou ʻia nā kūlana a pau.
Ma ka ʻāpana o ka ʻōnaehana pale: ma nā hihia kaʻawale, ʻike ʻia nā ʻano hypersensitivity, e hōʻike ʻia ana e ka hypotension arterial, ʻāʻulima, ka pīhoihoi anaphylactic. Kēia luhi loa, hiki ke hoʻomaopopo ʻia ka vasculitis allergic, a me ka hopena o ka cross-alika i nā sulfonamides, nā derogative sulfonylurea a i nā mea pili paha.
Ma ka ʻāpana o ka metabolism nui: maʻamau hypoglycemia.
Mai ka ʻaoʻao o ka mea nānā loiloi: i ka hoʻomaka ʻana o ka mālama ʻana, hiki ke hoʻopaʻa ʻia ka nānā ʻia ʻana o ka ʻike maka ma muli o nā hē o ka pae ʻana o nā ʻaila glucose.
Mai ka pūnaehana hana ʻana: miki, ka lua, ka ʻōpū, ka ʻeha o ka ʻōpū, ka manaʻo i ka piha o ka ʻōpū. Hōʻike kēia mau hōʻailona i ka hoʻokuʻu ʻana o ka lāʻau.
Mai ka ʻōnaehana hepatobiliary: hoʻonui i ka hana o nā enzyme o nā aihue. Nui loa - jaundice, cholestasis, hōʻeha ate, hepatitis.
Mai ka ʻili: itching, urticaria, exanthema, aneʻane loa - photosensitivity.
ʻO nā mea hoʻoweliweli eletise: pilikiaʻole - hyponatremia.

Nā Hoʻohui

Nā maʻi hoʻohālikelike i ka hoʻohana ʻana i ka lāʻau Alarahi nā: ketoacidosis, type I diabetes mellitus, coma diabetes, ʻeha hōʻeha a me nā maʻi pēpē, hypersensitivity i glimepiride a me nā sulfonylureas ʻē aʻe. ʻO nā maʻi o nā mea kōkua o ke Altar.

Hoʻopili pū me nā lāʻau ʻē aʻe

ʻOiai e lawe nei i ka lāʻau Alarahi me nā hua lāʻau ʻē aʻe, he nawaliwali palupalu a i ʻole makemake ʻia i loko o kona mau waiwai hypoglycemic ʻike. Hoʻopili ʻo Glimepiride i kona hopena ma ka cytochrome P450 2C9. Ua hōʻike ʻia ua pili pū ka hoʻohana ʻana i nā mea hana (no ka laʻana, rifampicin) a me nā cytochrome P450 2C9 (fluconazole) pili i ka hana o ka glimepiride.
ʻO ka hoʻonui ʻana i nā waiwai hypoglycemic o ka lālona Altar i nānā ʻia i ka wā e hoʻohana ʻia ai me ka phenylbutazone, azapropazone, oxyphenbutazone, sulfinpyrazone, oral antidiabetic drug, insulin, sulfanilamides me ka hana lōʻihi, tetracyclines, salicylates a me PASA, nā lāʻau kāne, nā lāʻau anabolic me nā anabolic drug, insulin, sulfanilamides me ka hana lōʻihi, tetracyclines, salicylates a me PASA, nā lāʻau kāne, nā lāʻau anabolic me nā anabolic drug, insulin, sulfanilamides me ka hana lōʻihi, tetracyclines, salicylates a me PASA, nā lāʻau kāne, nā lāʻau anabolic a me nā anabolic drug. , chloramphenicol, probenicide, Coumarin anticoagulants, miconazole, fenflura nā mines, pentoxifylline (i kēlā me kēia os.) nā fibrates, tritokvalin, nā papa ACE, fluoxetine, allopurinol, sympatholytic, cyclophosphamide, trophosphamide, ifosfamide, fluconazole. ʻO ka hoʻohaʻahaʻa ʻana i nā ʻano hypoglycemic o ka lālona Altar i nānā ʻia i ka wā e hoʻohana ʻia ai me ka estrogens a me nā progestogens, saluretics, thiazide diuretics, nā mākaʻikaʻi e hoʻōla i ka hana o nā kohu thyroid, GCS, phenothiazine a me nā derivatif chlorpromazine, epinephrine a me sympathomimetics, nicotinic, , finitoin, diazoxide, glucagon, barbiturates, rifampicin, acetazolamide. Block-adrenergic blockers a me H2-receptor blockers, reserpine a me clonidine hiki i nāwaliwali a hoʻonui i nā waiwai hypoglycemic o ka lāleʻa Altar. Ma lalo o ka mana o ka sympatholytics e like me ka reserpine, guanethidine, clonidine, a me nā blockers β-adrenergic, ka hopena o ka hoʻopiʻi adrenergic hoʻopaʻapaʻa o ka hōʻemi i nā pae glucose i nāwaliwali a i ʻole ʻole. Hoʻonui a hoʻomaikaʻi paha ʻo Glimepiride i nā hopena o nā derivatives Coumarin.

Ke keu

Aia kekahi puʻukū, hypertonicity, mydriasis, kahi haunaele moe, endocrine psychosyndrome (hele mai i ke ʻano, no ka hoʻohālikelike ʻana, ka huhū, ka huhū, ka hopohopo ʻike ʻana i ka hopohopo, ke kaumaha nei, ka hilahila), ke nele o ka hilinaʻi ʻana i nā neʻe, ka automatism primitive (hopu i nā neʻe, ka lanakila, anticceria), nā hōʻailona kumu (hemiplegia, diplopia, aphasia), kaʻaila, ʻūlū, koma, paʻa i ka lula a me ka hoʻopale ʻana o nā ʻōpū o ka hanu a me nā ʻōnaehana vascular.
Hoʻomaʻamaʻa. ʻO ka mea mua, ua lawe ʻia nā hana hoʻohiki e hoʻopau i ka lāʻau lapaʻau i lawe ʻia mai ke kino: ke komo ʻana i ka luaʻi, ka lua o ka gastric, ka hoʻohana ʻana o ka sodium sulfate a me nā carbon carbon. Hiki i ka hypoglycemia me ka nalowale o ka ʻike ʻole e hoʻopau ʻia e ka hoʻokele waha o 20 g o ka glucose, ka waiʻai a i ʻole ka wai wai. Ma nā kūlana koʻikoʻi o ka hypoglycemia, i hui pū ʻia me ka nalowale o ka hoʻomaopopo ʻana, pono ke hoʻonohonoho ʻana i kahi catheter venous pono, a laila e lawelawe ʻia ana he hopena 20% glucose (40-100 ml). Inā hoʻokomo ʻia kahi catheter, hiki ke lawelawe ʻia i ka 1-2 ml o ka glucoseagon i ka subcutaneously a i ʻole intramuscularly. Ma hope o ka hoʻihoʻi hou ʻana i ka ʻike no ka pale ʻana o ka hoʻi hou ʻana, pono ia e lawe i 20-30 g o nā mea hōʻeha i kēlā me kēia 2-3 mau hola i loko no nā hola 24-48. Ma hope o ka pau ʻana o ke ʻano hypoglycemic, nānā ka glucose i nā hola 48. I nā hihia e hoʻomau ʻia ana ka nalo o ka naʻau, e hoʻouka hou ʻia ka 5-10% glucose. Inā kū ʻole ke kiʻi o ka lāʻau lapaʻau, pono ʻoe e noʻonoʻo e pili ana i kekahi, ʻaʻole i pili me ka hypoglycemia, kumu o ka nalowale o ka ʻike. I ka hoʻohālikelike, pono ia e hana i ka maʻi maʻi no ka cerebral edema (sorbitol, dexamethasone) a nānā i ke kūlana o ka mea maʻi.

E hoʻokuʻu i ke ʻano

Nā 1 papa papa helu 30, 60, 90, 120
2 mg papa No 30, 60, 90, 120
3 mg papa inoa 30, 60, 90, 120.

1 papa i pili i ka glimepiride 1, 2 a i ʻole 3 mg.
Nā kumuwaiwai ʻē aʻe: Lactose Monxidate, Kālā Moku, Sodium Starch Glycolate (Type A), Polysorbate 80, Povidone, Talc, Magnesium Stearate.

ʻO keʻano o ka lāʻau Alatar

ʻO Alatar kahi lāʻau pili e pili ana i ka iniseti manuahi me ka hana ākea.Ma muli o ka hopena paʻakikī o nā mea ʻelua o ka lāʻau malathion a me ka cypermethrin, e hōʻoki koke nei ka mea hana i nā pōpoki o ka 28 mauʻano maʻamau.

No ka hoʻopiha hou ʻana o kēia mau ʻāpana ʻelua i nā hana a kekahi, ua hakakā ʻo Alatar me ka hele mua ʻana o nā ʻiʻini, nā kānaka nui a me nā pāhala.

Ka hoʻonohonoho ʻana a me ke ʻano o ka hoʻokuʻu ʻana

No ka hoʻonui i ka hana o Alatar, ʻo kāna mea pūnaehana ka mea nui a me nā māhele kōkua:

• Milatonin, e pili ana me nā pūnaehana phosphate organic. Loaʻa ka pahuhopu i nā hopena ʻona no ka hapanui o nā iniseti e hānai ana i nā mea kanu, hua a me nā mea kanu ornamental.
• He ʻano nui ka pyrethroid ka Cypermethrin e hana nei i ka maʻi pālolo.
• Hoʻokomo i nā mea hoʻoikaika kaha, e hoʻomaikaʻi i nā hopena o nā mea hana ʻelua,
• Nā kumuwaiwai hou, hoʻopaʻa i nā mea a me nā ʻāpana o nā antioxidants.

Hoʻomehana hana i nā hana i nā pōpoki

ʻO ka lāʻau lapaʻau, ma muli o ka hana a me ka hana wikiwiki no ʻelua mau mea ikaika i ka manawa hoʻokahi, ke komo ʻana i ka ʻōpū o kahi iniseti, a i ʻole hana i ka lolo (larvae) i ka ʻōnaehana pololi, ma ka ʻā ʻana o ka maʻi pālule. Ma muli o ka immobilization a me ka hikiʻole i ka ʻai, make koke ka mea pehu.

Eia kekahi, aia nā Alatar e hoʻopili pono i nā kumulāʻau kūikawā, ke aloha nei i ka mea i ka lāʻau huʻala i ka lau o nā lau a i nā kumu hilinaʻi no ka manawa lōʻihi. ʻOiai ma hope o ka pohō nui a ka ua paha, ʻaʻole i pau ka hopena o Alatar, ʻoiai no ka hoʻopili mau i ka lau ma luna o nā lau ma hope o ka hoʻopili ʻana me ka wai.

Lapaʻau lāʻau

ʻO ka waiwai glimepiride e hoʻohaʻahaʻa i nā haʻahaʻa kō. Hoʻohana ʻia ka lāʻau lapaʻau no ka hoʻomehana me kahi ʻano hana like me ka maʻi diabetes. Hana ka mea hana ikaika ma ka hoʻoulu ʻana i ka hoʻokuʻu mai ka insulin mai nā pancreatic β-cells. Hana ʻia kēia hana ma muli o ka hoʻonui ʻia o ka pane ʻana o nā β-cell i hoʻoulu ʻia e ka ala physiological e ke kō.

Kōkua ʻo Glimepiride i ka huni o ka insulin ma o ka hoʻoulu ʻana i nā kaila pālala, e hilinaʻi ana i nā mea ATP (i loko o ka membrane o nā β-cells). Hoʻopili ia, loaʻa ka hopena i ka hopena extrapancreatic, e hoʻonui ana i ka hoʻololi ʻana o nā kinoleka peripheral e pili ana i ka insulin, me ka hoʻēmi ʻana i nā pae o ka hepatic absorption o ka insulin.

Lapaʻau lāʻau

Ma hope o ka ingestion, hōʻike a glimepiride i ka bioavailability piha. ʻAi liʻiliʻi i ka pā ʻana o ka lāʻau lapaʻau - kona kiʻekiʻe ma kēia hihia e hoʻēmi iki ʻia. Kānā ʻia nā waiwai o ka serum Peak ma hope o nā hola he 2 ma hope o ka hoʻokomo ʻana o ka papa i loko. ʻO nā waiwai koʻikoʻi i loko o ka serum o ke koko linearly correlate me ka nui o ka nui o ka lāʻau.

Loaʻa iā Glimepiride kahi hōʻailona haʻahaʻa o ka laha mahele (e pili ana i 8,8 l), e like me ia no ka albumin. Loaʻa iā ia ka waiwai he kiʻekiʻe i ka synthesis o ka protein (ʻoi aku ma mua o 99%) a me nā haʻahaʻa clearance haʻahaʻa (48 ml / mau minuke).

ʻO ka hapalua hapalua o ke koko serum e loaʻa nei ma kahi o 5-8 hola. Ma hope o hoʻokahi ala o nā lāʻau lapaʻau, ua hōʻike ʻia nā pae like o ka radioactivity: i ka pā ʻana, 58%, a i loko o feces, 35%. I kēia hihia, ʻaʻole ʻike ʻia ka māhele like ʻole i loli ʻia i loko o ka urine.

ʻO ka pilina me nā lāʻau lapaʻau ʻē aʻe

Ke hoʻohui nei i ka lāʻau lapaʻau me nā lāʻauʻokoʻa ʻē aʻe, he hōʻemi a i ʻole ka nui o ka piʻi ʻana ma ka hopena hypoglycemic hiki. Hoʻopilikia ka Glimepiride i ke kino me ke kōkua o hemoprotein P450 2C9. Ua hōʻike ʻia e pili ana nā kaʻina metabolic o kēia mau mea e ka mea hana i hoʻohana ʻia e hui pū ai ((like me rifampicin) a i ʻole inhibitors (e like me fluconazole) o ka hemoprotein P450 2C9.

ʻO ka hoʻonui i ka hopena hypoglycemic o Altara e loaʻa i ka hihia o ka hui pū me ka sulfinpyrazone, a i hui pū ʻia me oxyphenbutazone, azapropazone a me phenylbutazone. Hōʻike ka hopena like i ka wā e hoʻohui ʻana i nā lāʻau lapaʻau me nā lāʻau hypoglycemic waha, tetracyclines, MAOI, sulfonamides (me ka lōʻihi o ka hōʻike) ʻana mai, insulin, PASK a me salicylates. Eia kekahi, me nā hormones sex (male) a me nā mea hoʻohui anabolic, nā lāʻau antibacterial mai ka quivoliv derivative kategorya, a me ka probenicide, chloramphenicol, fenfluramine, Coumarin anticoagulants a me miconazole me ka pentoxifylline (nui (nui). Aia kēia papa inoa i nā inhibitor ACE, fibrates, fluoxetine me tritokvalin, sympatholytics, allopurinol, trophosphamide a me cyclophosphamide, a me ka fluconazole a me ifosfamide.

ʻO ka nāwaliwali o ka hopena hypoglycemic o ka lāʻau ke loaʻa i ka hihia o ka hui pū me nā progestogens a me estrogens, a me ka thiazide diuretic nā lāʻau, saluretics, hana thyroid e hōʻeuʻeu i nā lāʻau, epinephrine a me GCS, a me ka sympathomimetics a me nā derivia phenothiazine me ka chlorpromazine. Pēlā i hui pū ʻia me niacin a me kāna mea waiwai, phenytoin, laxatives (me kā lākou hana lōʻihi), glucagon a me diazoxide, a me rifampicin, barbiturates a me acetazolamide.

ʻO nā mea hōʻeha ke pale aku i ka hopena o ka hopena β-adrenergic a me ka hoʻopau ʻana i ka H2, a ma ke ʻano, ʻo ka clonidine me ka reserpine hiki i ka potentiate a hoʻonāwaliwali i ka hopena hypoglycemic o ka lāʻau. Ma lalo o ka hopena o ka sympatholytics (ma waena o lākou he clonidine me ka reserpine, nā lāʻau lapaʻau e ʻae ana i ka ʻenekela β-adrenergic, a me ka guanethidine), ka hopena o ka hopena adrenergic uku, kahi i hāʻawi ʻia i ka hoʻemi i ka waiwai glucose, hiki ke hoʻēmi a ʻalo loa.

Kūʻino a Glimepiride a i ʻole ka manaʻo i ka hopena o nā derivatives o Coumarin.

, ,

Nā hopena maikaʻiʻole

Hoʻohana ʻia ka papa inoa i kēia mau mea e loiloi ai i ka ulu hewa ʻana: pinepine pinepine> 1/10, pinepine:> 1/100 a me 1/1000 a me 1/10 000 a me ka 1)

1) Thrombocytopenia, leukopenia, erythrocytopenia, granulocytopenia, agranulocytosis, hemolytic anemia, pancytopenia, kahi, ma ke ʻano, e nalo ana i ka wa e pau ai ka lāʻau, hiki ke mālama ʻia.

2) Hiki i nā mea maʻi maʻamau ke ulu i loko o nā hopena koʻikoʻi me ka hoʻolālā ʻana o ke pōkole o ka hanu, ka hypotension arterial, a i kekahi manawa me ka hoʻolālā ʻana o ka pīhoihoi.

3) Hoʻomau pinepine ka hopena hypoglycemic i ka manawa koke, hiki ke hōʻeha a ʻaʻole maʻalahi ke hoʻoponopono.

4) Hiki i ke nānā ke ʻike i ke aniani ka ʻike pinepine ʻia i ka hoʻomaka ʻana o ka hoʻomaʻamaʻa ʻana a ua kumu ma ka hoʻololi ʻana o ke kao o ka glucose i loko o ke koko.

5) ʻO nā hoʻopiʻi mai ka hana mai ka digestive i kekahi manawa i ka haʻalele ʻana o ka lāʻau.

6) Hiki i ka Hepatitis ke hōʻeha i ka naʻau.

Hoʻohana i ka wā hāpai a me ka lactation

ʻAʻole lawa nā data ma ka hoʻohana ʻana o glimepiride no nā wahine hāpai, no laila ʻaʻole pono e hoʻohana ʻia i loko o ke kō holoʻokoʻa.

ʻAʻole i ʻike ʻia, hele ka glimepiride i ka waiū umauma. Ma muli o ke kolo o nā sulfonylureas e komo i loko o ka waiū umauma, aia kahi maʻi o ka haogogogemia i loko o ka pēpē, no laila, i ka wā e hoʻohana ai i ka glimepiride, pono i ka umauma e hōʻoki ʻia.

ʻAʻole pono ke hoʻohana ʻia ʻo Glimepiride i nā keiki ma muli o ka ʻike hemahema.

Ua hoʻonele luhi i ka maʻi pest?

Ma ka'āina a i ʻole nā ​​moa paha ka hale, nā mea ʻeha a me nā mea ʻē aʻe i hōʻeha ʻia? Pono ʻoe e kaua me lākou! ʻO lākou ka poʻe lawe i nā maʻi koʻikoʻi: salmonellosis, rabies.

Nui nā poʻe noho o ke kauwela i mua i nā pōʻino e luku i ka hua a hōʻino i nā mea kanu.

I kēlā mau kūlana, ʻōlelo kā mākou mea heluhelu e hoʻohana ai i ka mea hoʻowalewale hou loa - ka mea kūʻai palapala Pest Reject.

Aia i ia mau waiwai:

• Hoʻopau ia i nā ʻuaka, ka ipuka, nā rodents, nā kime, nā popo
• Palekana no nā keiki a me nā holoholona
• Hoʻomaʻi nā kikika, ʻaʻohe koi hou
• ʻAʻohe hopena hoʻoili i nā pōpoki
• ʻO nā wahi nui o ka hana hana

Nā hiʻohiʻona noi

Pono e hoʻohana koke ʻia nā papa ma mua a i ʻole me ka pāʻina.

Me ka nui o ka ʻai ʻana i ka meaʻai a i ʻole ke kāʻili ʻia ka meaʻai, hiki i ka hoʻohana ʻana o ka glimepiride ke alakaʻi i ka hypoglycemia. Hiki ke ʻano o ke ʻano o ka hypoglycemia: ʻeha, ka pōloli nui, ka ʻōpū, ka luaʻi, ka nui o ka māhina, ka hiamoe, nā hopohopo hiamoe, ke ʻano hopohopo, ka huhū, ka piʻi ʻana o ka manawa, nui ka manawa, ka manawa, ka ninaninau, ka haunaele, ka ʻōlelo a me nā haunaele, nā aphasia, ka haʻalulu, paresis, pilikia haunaele, dizziness, helplessness, nalowale o ke kiaʻi ponoʻī, delirium, cramps, drowsiness a me ka nalowale o ka manaʻo me ka hoʻomohala ʻana i ka precoma a me ka coma, hanu make, bradycardia.

Eia kekahi, ʻo nā hōʻailona e like me ka luhiluhi, ka uau clammy, hopohopo, tachycardia, hypertension arterial, palpitations puʻuwai, angina pectoris, a me nā mea e hōʻeha nei i ka naʻau. ʻO ka hōʻike hoʻohālikelike o ka hypoglycemia koʻikoʻi e like me ka hōʻike ʻana o ke kauka ma kahi maʻi.

Hiki ke hoʻokaʻawale koke ke ʻano o ke ʻano o ka hypoglycemia ma ke hoʻopau ʻana i nā kao (gula). ʻAʻole kūpono nā mea hoʻihoʻi gula.

Mai ka ʻike me nā lālani sulfonylurea ʻē aʻe, ua ʻike ʻia ka hiki ʻana o ka hypoglycemia ke kū aʻe i ka hopena o ka hopena. ʻO ka hypoglycemia koʻikoʻi a lōʻihi paha, ke kāohi ʻole ʻia e ka hoʻohana ʻana o ke kō, e koi koke i ka mālama ʻana me nā lāʻau lapaʻau a, inā paha, hoʻokipa ʻia.

Hiki i kēia mea ke hana i ka hoʻomohala ʻana o ka hypoglycemia: ka makemake ʻole o ka mea maʻi a i ʻole hiki ʻole ke hana pū me ke kauka (ʻoi aku paha no nā poʻe ʻelemakule), ʻona kaʻai ʻole, ka ʻōpū ʻole ʻana i ka pōʻai a i ka pōloli, ka make pōpilikia ma waena o ka hana kino a me ka hoʻowaleka o ka lāʻai, nā loli i ka meaʻai, ka hoʻohana ʻana i ka wai ʻona. i ka hui pū ʻana me nā kīhāpai i nā meaʻai, nā hana a ka mea hōʻeha ʻole, ka hana o ka puʻuwai hemahema, kahi overdose o ka glimepiride, kekahi mau maʻi kīnā ʻole o ka ʻoihana endocrine, ka huina o nā mea kalaiola a i ʻole hana ma ke ʻano he counter-regulator o ka hypoglycemia (kekahi mau hana o ka momona thyroid, ka ʻole o ka pituitary anterior a cortex adrenal), hoʻohana pono ʻana i nā ʻano lāʻau ʻē aʻe.

I ka wā e mālama ai me ka glimepiride, pono ka nānā pono ʻana i nā ʻokoʻa nā mea e pono ai: he koko koko a me nā pae i ka urine, nā pae hemoglobin glycosylated, nā mākau pili hana aʻai, kiʻi koko (me ka helu o ka leukocytes a me nā platelets)

ʻO ka hiki ke alakaʻi i ka hopena i ka wā e lawe ana i nā kaʻa a i ʻole nā ​​hana ʻē aʻe

I ka poʻe maʻi me ka maʻi mellitus, ma muli o nā hopena hiki i ka hyp- a i ka hyperglycemia, a me ka pilina me ka hiki ke ʻike i nā hana nānā, hiki ke hoʻemi ʻia ka hiki ke hoʻāla ʻia, ka mea hiki ke hoʻopilikia i ka wā e lawe ana i ka kaʻa a lawelawe i nā ala kūloko. No laila, e kuhikuhi ʻia e lawe i nā ʻōkuhi pono e pale aku i ka hiki o ka hypoglycemia i ka wā o ka hoʻokele. He mea koʻikoʻi kēia no kēlā mau maʻi i loaʻa pinepine nā manawa hypoglycemia a i ʻole ka hōʻemi a i ʻole a i ʻole ka ʻike maʻamau i nā hōʻailona o nā hōʻailona o ka hypoglycemia. I kēlā mau hihia, pono ʻoe e noʻonoʻo i ka kūpono o ke kaʻa.

ʻO nā waiwai Pharmacological

Lapaʻau ʻO Glimepiride ka mea e hoʻohana ai i ka lawehala hypoglycemic maikaʻi e hoʻohana ʻia i ka mālama ʻana i nā mea maʻi me ka diabetes mellitus-non-insulin.

Lapaʻau lāʻauKapehu. ʻO ka bioavailability o glimepiride ma hope o kāna kūloko waha. ʻAʻole nui kaʻai ʻana i ka ʻai i ka lohi ʻana, akā e emi iki ka hapa o ka absorption. Ka ʻike kiʻekiʻe ma ka serum (C _max ) ma hope o ke kau hou ʻana ma hope o nā hola he 2 (ma ka awelika 0.3 μg / ml me ka hoʻokele hou ʻana ma ka maʻa o 4 mg i kēlā me kēia lā), a me ka pilina laina ma waena o ka pume a me ka C e nānā _max e like me ka wahi i lalo o ke kālai ʻāwili-manawa (AUC).

Kahele. I ka glimepiride, kahi kikoʻī liʻiliʻi hoʻoili liʻiliʻi (ma ka 8.8 lita) me ke kūlike o kēlā me kēia ma ka albumin, he heluna nui e pili ana i ka protein (> 99%) a me kahi hoʻomaʻemaʻe liʻiliʻi (ma kahi o 48 ml / min).

ʻO ka metabolism a me ka holoiʻana. ʻO ka hapalua hapalua o ka serum paha ma kahi o 5-8 hola. Ma hope o hoʻokahi kahe o ka glimepiride me kahi hōʻailona radioaktif, ua ʻike ʻia ka radioactivity i loko o ka urine (58%) a me nā maʻi (35%). ʻAʻole i hōʻike ʻia ka mea hoʻouluulu i loko o ka urine. Ua hōʻike ʻia he ʻelua mau metabolite i loko o ka urine a me nā feces: ʻo ka mea hauhā o ka hydroxy a me ka glidepiride carboxypochidne. Ma hope o ka lawe ʻana i ka glimepiride, ka hapalua o ka manawa hope o kēia mau metabolite he 3-6 mau hola a me 5-6 mau hola, kēlā Ke hoʻohālikelike nei i nā kiko o hoʻokahi manawa i kēlā me kēia lā a me ka hoʻākāka ʻole ʻana i nā hōʻailona koʻikoʻi, ʻaʻole nui loa ka ʻano o nā ʻano like ʻole. ʻAʻole i nānā ʻia kahi koi nui. Ua nānā ʻia kahi pharmacokinetics like i loko o nā kāne a me nā wahine, ʻo ia hoʻi i ka poʻe maʻi o nā ʻōpio a me nā maʻi e ʻoi aku ma mua o 65 mau makahiki.

Nā hana hana

ʻO ka hana nui

ʻO kahi. X-17 / X-18, O.I.D.Ts., Mahatma Gandhi Udiog Nagar, Dubhel, Daman 396210, India.

"Ma ka nui" hana, ka hoʻopiha hope, ka hoʻonohonoho ʻana:

A.Menarini Ka Hana ʻana i nā loiloi a me nā lawelawe S.r.l.

ʻO kahi. Via Campo di Pile 67100 LʻAquila (AK), Italia.

A. Menarini Manufacturing Logistics & Services S.r.l.

ʻO kahi. Via Sete Santi 3, 50131 Florence (FI), Italia.

Kuhi ʻana iā Alatar

He nui ke ʻano o Alatar, he mea hoʻopale i ka colorado, codling aū, ʻōpū, nā ʻōpala, nā lauworms, nā aphids, nā kolo, nā kīwī, nā keʻokeʻo, nā wele, nā kiki a me nā mea he nui ʻē aʻe e hoʻopōʻino i nā mea kanu a me nā mea kanu kūloko. Hiki ke hoʻokaʻawale ʻia ka hoʻohana ʻana i ka lāʻau i loko o ka mālama ʻana i nā mea kanu kūloko, nā mea kanu horticultural.

No nā lāʻau kūloko

ʻO ka mālama ʻia ʻana o nā pua kūloko a me nā ʻala hale home e hoʻokau ʻia ana e ke Alatara. Akāʻo ke kaʻina hana pono e mālama pono ʻia, no ka mea ua mālama ʻia ke kaʻina hana i kahi wahi i hoʻopuni ʻia me ka hoʻoweliweli ʻana.

Hoʻolaha ʻia ka hana ʻana o nā mea kanu kūloko ma Alatar no:

• E hoʻohemo i nā aphids, thrips, moths a me nā mea ʻino ʻē aʻe e hānai ana i nā pua nani a me nā hua lāʻau
• E pale i nā mea inikini ua hoʻopau i nā lāʻau palaʻai e ulu ana i loko o ka hale.
• I mea e pale ai i ke ʻano o ke koko anuanu a kāpae i kā lākou hoʻi ʻana mai.

No nā mea kanu hortikultural

Ma nā māla a me nā māla lāʻau, hoʻohana ʻia ʻo Alatar ma kahi o kēlā me kēia mahele o ka māla ʻona me ka ʻike, no ka mea, ua pilikia nā pilikia me nā pua, nā mea kanu a me nā lāʻau hua.

• E kau i kahi mea hana no ka luku wikiwiki ʻana i nā pōpoki kalepa o Colorado,
• E hoʻopau i nā kumulāʻau e hoʻopau aku i ka mauʻu a me nā lau,
• E hoʻokaʻawale i ke ʻano a kaua aku i nā aphids maʻamau, kikoʻī a me nā currant.
• ʻO ka pepehi ʻana i nā mea make i nā mea ʻeha a me nā hua ʻai, e like me nā weevils,
• No ka luku ʻia ʻana o nā pōpoki e hoʻopau ana i nā hua ʻai mea kanu, ma ka ʻano o kahi scoop, lele mai ʻo kāpeti, ʻōpala, pōʻai a me nā ʻōpala lau,
• No ka hōʻoia i ka hopena o ka pale ʻana o ka helehelena a hoʻihoʻi paha i nā mea āpau i hōʻike ʻia a me nā mea ʻē aʻe he nui wale.

Nā helu haʻahaʻa

Aia ma kahi o ka hana e kau ʻia ana i ka wā e hoʻohana ai i kahi mea inikini, e loli pū ka nui o kona hoʻohana ʻana i ka wā o ka spraying.

ʻO nā ʻōnaehana noi nui no ka hoʻopaʻa ʻana i nā mea kanu hua lāʻau:

• No ke kūleʻa i colorado, weevil a me nā mea ʻai ʻē aʻe e hānai ana i nā mea kanu huaʻai, kī ʻia he 5 ml ampoule me 4 lita o ka wai. Hoʻomoe ʻia ka pīpī i ka wā o ka pua, me kahi helu ʻai o 4 lita o ka lehu i loaʻa ma kahi o 100m2.
• No ka hōʻino ʻana i ka lele o ke aniani, ua lawe ʻia nā mea maʻi ʻelua me ka hopena like ʻole e like me ke colorado.
• ʻO ka hoʻopau ʻana i ke kumu a me nā lau e hoʻopili ai i ka hoʻōla me ka ampoule o ka lāʻau, hoʻoheheʻe ʻia i 10 lita o ka wai.E hoʻoulu i ka 5 lita i ka wā o ka pua o ka lāʻau.
• I mea e luku ai i nā aphids, 5 ml o ka lāʻau lapaʻa i hoʻopauʻia i 5 lita o ka wai. Pono e hana i ka hoʻoili ʻana i ka wā e ulu ana ma ka manawa o 1 lita no kēlā me kēia kumulāʻau.
• ʻO ka pale a me ka mālama ʻana i nā pua nani a me nā mea kanu lāʻau e lawe ʻia me ka hoʻonā o ka haʻalulu o ke 10 lita o ka wai i hoʻokahi pā. Hoʻokahi kauka lāʻau no kahi ma mua o 5 lita o ka lehu ma kahi o 100 sq.m. kanu ʻāina.

ʻO ka lāʻau lapaʻau

I ka wā e hoʻomākaukau ʻia ai ka hopena no ka mea kanu, hoʻomau lākou i ka hōʻino ʻana i ke koko anuanu.

Nā ʻōkuhi no ka hoʻoulu ʻana i nā mea kanu me Alatar:

• ʻO ka mālama pono ʻana i ke kūleʻa o ka pīpī me ka lāʻau lapaʻau, ka mālama ʻia ʻana o nā lau o ka mea kanu me ka pū pālaula,
• Hoʻopili ʻia ka pipiʻi i nā lā maloʻo a ma hope o ka hoʻoulu ʻana
• ʻO ka ʻaoʻao o ka makani e pono ke ʻike ʻia, no ka mea ʻaʻole pono e ʻoka ʻia ka lāʻau i hala ma mua o nā mea kanu,
• Ma ke alanui ʻaʻole pono ia i ka mahana ma mua o 25 mau kiʻekiʻe (a i ʻole ka liʻiliʻi ma mua o 12 mau kiʻekiʻe), no ka ʻike ʻole ʻana i ka lula ʻana i ka hopena, he hopena ia i ka lōʻihi o ka hana o nā mea hoʻohui.

ʻO nā mea mālama palekana

I ka wā o ka pīpī ʻana aku pono kahi kanaka i pani ʻia me nā mahi lima paʻa. Pono ka maka i ka mask a i ka respirator, a me nā goggles, no ka mea e hoʻopili ana i kahi mea oona e hoʻohā ai me nā membous mucous a i nā maka paha ke waiho i nā kukui kuni.

Inā hele ma Alatar i ka ʻili a i ʻole nā ​​memous paha, a i ʻole nā ​​maka - pono e holoi koke ʻia kēia mau wahi i ka nui o ka wai mahana.

Ma hea e kūʻai aku ai a pehea ehia ka lāʻau lapaʻau?

ʻAʻole paʻakikī ko Alatar, e noi e pili ana i ka loaʻa o ka lāʻau lapaʻau i kekahi hale kūʻai kūikawā. Eia nō, he ʻano demokalona ke kumukūʻai o ka huahana, no ka mea, me kahi pahu me 25 ml pono e uku ʻia ʻoe ma mua o 70-80 rubles.

A i ʻole ʻoe e ʻike i ka lāʻau lapaʻau ma ka Pūnaewele. ʻO kahi helu o nā pūnaewele nui e hoʻolako i kahi manawa ʻaʻole wale e kauoha i ka lāʻau lapaʻau ma ka home, akā e hāʻawi pū i nā ʻōlelo aʻo i ka hoʻohana ʻana. Hoʻololi ʻia ke kumukūʻai i loko o ka pūnaewele mai 40 a 70 mau rubles no 25 ml o Alatar.

Ka hana lāʻau lapaʻau

ʻO ka mea waiwai he glimepiride - kahi loea hypoglycemic maikaʻi i hoʻohana ʻia e mālama i nā mea maʻi me ka maʻi mellitus. Paipai ʻo Glimepiride i ka hoʻokuʻu ʻana o ka insulin e nā pancreatic β-cells. Hoʻopili ʻia kēia hopena me ka pane nui o ka ʻβ o nā cell i ka hoʻoikaika kūlohelohe kūlohelohe. Loaʻa iā Glimepiride ka bioavailability o ka pau ʻana o ka hoʻokō waha. ʻAʻole ʻike nui ka ʻai i ke kahe ʻana o ka lāʻau lapaʻau, aia ka palena iki wale nō i ka pae o ke kīnā ʻana. Ka kaukaʻi ʻoi loa i ka ʻai i loko o ka serum i hoʻopaʻa ʻia he mau hola 2.5 ma hope o ka lawelawe waha. Hoʻomaopopo ka pilina laina ma waena o ke ʻano o ka glimepiride a me kona hoʻokō nui ʻana ma ka serum koko. Loaʻa iā Glimepiride kahi kiko liʻiliʻi liʻiliʻi (ma kahi o 8,8 L), e like me kēlā me ka albumin, kahi kiʻekiʻe e hoʻopili ana i nā protein plasma (ʻoi aku ma mua o 99%) a me ka haʻahaʻa haʻahaʻa (48 ml / min).

ʻO ka hapalua hapalua o ka serum mau haʻahaʻa 5-8 mau hola. Me ka hoʻokele hoʻokahi o ka glimepiride me kahi hōʻailona radioaktif, ua hoʻopaʻa ʻia ka radioactivity o ka urine (58%) a me nā moena (35%). ʻAʻole hoʻoholo i nā mea hana i hoʻololi ʻia i loko o ka urine. I ka hoʻohālikelike ʻana i nā helu he nui a hoʻokahi, ʻaʻole i loli nui ka pharmacokinetics o ka lāʻau lapaʻau, a ʻaʻole i like ka nui o ka loli o ke ʻano o nā fluctuation. ʻAʻole ʻike ʻia ka cumulation nui. I nā kāne a me nā wahine, ʻoiai ʻo nā ʻōpio a me nā poʻe ʻōpio (ʻoi aku ma mua o 65 mau makahiki), kahi hua lāʻau lapaʻau like ʻole i mālama ʻia. Hōʻemi ka hoʻoemi ʻana i ka ʻike o ka glimepiride i loko o ka serum koko i ʻike ʻia i nā kānaka me kahi haʻahaʻa haʻahaʻa haʻahaʻa, ka mea e pili pū me ka wikiwiki o nā hana ikaika (ma muli o ka palena haʻahaʻa o ka protein plasma). ʻO ka hoʻonui ʻia o ka hōʻemi i kēia pūʻulu o nā mea maʻi ʻaʻole paha e like.

Hoʻohui nūhou

Me ka hoʻomohala mau ʻana o ka lāʻau Altar me kekahi mau lāʻau lapaʻau hou aʻe, ʻike ʻia kahi nāwaliwali a nawaliwali ʻole e hoʻonui ʻia i kona mau hypoglycemic waiwai. Hoʻopili ʻo Glimepiride i kona hopena ma ka cytochrome P450 2C9. Ua hōʻike ʻia ua pili pū ka hoʻohana ʻana i nā mea hana (no ka laʻana, rifampicin) a me nā cytochrome P450 2C9 (fluconazole) pili i ka hana o ka glimepiride.
ʻO ka hoʻonui ʻana i nā waiwai hypoglycemic o ka lālona Altar i nānā ʻia i ka wā e hoʻohana ʻia ai me ka phenylbutazone, azapropazone, oxyphenbutazone, sulfinpyrazone, oral antidiabetic drug, insulin, sulfanilamides me ka hana lōʻihi, tetracyclines, salicylates a me PASA, nā lāʻau kāne, nā lāʻau anabolic me nā anabolic drug, insulin, sulfanilamides me ka hana lōʻihi, tetracyclines, salicylates a me PASA, nā lāʻau kāne, nā lāʻau anabolic me nā anabolic drug, insulin, sulfanilamides me ka hana lōʻihi, tetracyclines, salicylates a me PASA, nā lāʻau kāne, nā lāʻau anabolic a me nā anabolic drug. , chloramphenicol, probenicide, Coumarin anticoagulants, miconazole, fenflura nā mines, pentoxifylline (i kēlā me kēia os.) nā fibrates, tritokvalin, nā papa ACE, fluoxetine, allopurinol, sympatholytic, cyclophosphamide, trophosphamide, ifosfamide, fluconazole.

ʻO ka hoʻohaʻahaʻa ʻana i nā ʻano hypoglycemic o ka lālona Altar i nānā ʻia i ka wā e hoʻohana ʻia ai me ka estrogens a me nā progestogens, saluretics, thiazide diuretics, nā mākaʻikaʻi e hoʻōla i ka hana o nā kohu thyroid, GCS, phenothiazine a me nā derivatif chlorpromazine, epinephrine a me sympathomimetics, nicotinic, , finitoin, diazoxide, glucagon, barbiturates, rifampicin, acetazolamide.
Block-adrenergic blockers a me H2-receptor blockers, reserpine a me clonidine hiki i nāwaliwali a hoʻonui i nā waiwai hypoglycemic o ka lāleʻa Altar. Ma lalo o ka mana o ka sympatholytics e like me ka reserpine, guanethidine, clonidine, a me nā blockers β-adrenergic, ka hopena o ka hoʻopiʻi adrenergic hoʻopaʻapaʻa o ka hōʻemi i nā pae glucose i nāwaliwali a i ʻole ʻole. Hoʻonui a hoʻomaikaʻi paha ʻo Glimepiride i nā hopena o nā derivatives Coumarin.